METTL18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.25266637
2ribosomal small subunit assembly (GO:0000028)4.91149254
3maturation of SSU-rRNA (GO:0030490)4.76949742
4nucleobase biosynthetic process (GO:0046112)4.48037487
5IMP metabolic process (GO:0046040)4.41620692
6DNA double-strand break processing (GO:0000729)4.39701602
7respiratory chain complex IV assembly (GO:0008535)4.34656018
8DNA replication initiation (GO:0006270)4.31554512
9purine nucleobase biosynthetic process (GO:0009113)4.28458679
10DNA strand elongation involved in DNA replication (GO:0006271)4.19773977
11formation of translation preinitiation complex (GO:0001731)4.07125201
12mitotic metaphase plate congression (GO:0007080)4.04100340
13ribosomal large subunit biogenesis (GO:0042273)3.98187005
14negative regulation of fibroblast apoptotic process (GO:2000270)3.96341100
15DNA strand elongation (GO:0022616)3.95669939
16ribosome assembly (GO:0042255)3.93233101
17proteasome assembly (GO:0043248)3.91631852
18viral transcription (GO:0019083)3.88240737
19RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.85510038
20tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.85510038
21IMP biosynthetic process (GO:0006188)3.85204337
22telomere maintenance via semi-conservative replication (GO:0032201)3.84413060
23folic acid-containing compound biosynthetic process (GO:0009396)3.81294293
24DNA ligation (GO:0006266)3.81165994
25cullin deneddylation (GO:0010388)3.80869996
26translational termination (GO:0006415)3.80323011
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.79655570
28DNA unwinding involved in DNA replication (GO:0006268)3.77645668
29protein complex biogenesis (GO:0070271)3.77495150
30cytochrome complex assembly (GO:0017004)3.77329689
31mitochondrial respiratory chain complex assembly (GO:0033108)3.74504438
32protein deneddylation (GO:0000338)3.72764467
33ribosome biogenesis (GO:0042254)3.65065233
34histone exchange (GO:0043486)3.63010244
35DNA replication checkpoint (GO:0000076)3.62846323
36ribonucleoprotein complex biogenesis (GO:0022613)3.62012401
37nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.61472458
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59259420
39regulation of spindle organization (GO:0090224)3.58507572
40mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.56256061
41mitochondrial respiratory chain complex I assembly (GO:0032981)3.56256061
42NADH dehydrogenase complex assembly (GO:0010257)3.56256061
43establishment of integrated proviral latency (GO:0075713)3.55357689
44translational elongation (GO:0006414)3.54063044
45rRNA modification (GO:0000154)3.53633505
46mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51759975
47chaperone-mediated protein transport (GO:0072321)3.50593863
48regulation of mitotic spindle checkpoint (GO:1903504)3.48267635
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.48267635
50protein K6-linked ubiquitination (GO:0085020)3.47852469
51DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.46903555
52rRNA processing (GO:0006364)3.44839800
53metaphase plate congression (GO:0051310)3.44704989
54signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.43179720
55signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.43179720
56signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.43179720
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.42811723
58ATP synthesis coupled proton transport (GO:0015986)3.42811723
59ribosomal small subunit biogenesis (GO:0042274)3.41096970
60translational initiation (GO:0006413)3.40923095
61CENP-A containing nucleosome assembly (GO:0034080)3.40356082
62spliceosomal snRNP assembly (GO:0000387)3.40105059
63transcription elongation from RNA polymerase III promoter (GO:0006385)3.39244802
64termination of RNA polymerase III transcription (GO:0006386)3.39244802
65platelet dense granule organization (GO:0060155)3.39117247
66intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.38510483
67signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.38510483
68protein localization to kinetochore (GO:0034501)3.38284798
69chromatin remodeling at centromere (GO:0031055)3.34738112
70DNA replication-dependent nucleosome assembly (GO:0006335)3.32615810
71DNA replication-dependent nucleosome organization (GO:0034723)3.32615810
72mitotic nuclear envelope disassembly (GO:0007077)3.31278377
73rRNA metabolic process (GO:0016072)3.31120892
74negative regulation of DNA-dependent DNA replication (GO:2000104)3.30528293
75telomere maintenance via recombination (GO:0000722)3.30400925
76SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28564942
77signal transduction involved in cell cycle checkpoint (GO:0072395)3.28256785
78transcription-coupled nucleotide-excision repair (GO:0006283)3.27879188
79signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27736554
80signal transduction involved in DNA damage checkpoint (GO:0072422)3.27736554
81regulation of cellular amino acid metabolic process (GO:0006521)3.26717463
82spliceosomal complex assembly (GO:0000245)3.25752818
83establishment of protein localization to mitochondrial membrane (GO:0090151)3.25719932
84DNA deamination (GO:0045006)3.25503483
85anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.24477636
86somatic hypermutation of immunoglobulin genes (GO:0016446)3.24079684
87somatic diversification of immune receptors via somatic mutation (GO:0002566)3.24079684
88regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.23328299
89positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21361415
90cotranslational protein targeting to membrane (GO:0006613)3.21286145
91nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21249445
92negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.21040814
93establishment of chromosome localization (GO:0051303)3.20894782
94kinetochore organization (GO:0051383)3.20751847
95histone mRNA metabolic process (GO:0008334)3.20032660
96DNA catabolic process, exonucleolytic (GO:0000738)3.19460778
97protein targeting to ER (GO:0045047)3.18007176
98tRNA methylation (GO:0030488)3.16740254
99maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.14956890
100mitotic recombination (GO:0006312)3.14534793
101protein localization to endoplasmic reticulum (GO:0070972)3.14236665
102regulation of histone H3-K9 methylation (GO:0051570)3.10489096
103attachment of spindle microtubules to kinetochore (GO:0008608)3.10231909
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08705391
105regulation of mitochondrial translation (GO:0070129)3.06943029
106respiratory electron transport chain (GO:0022904)3.06454650
107negative regulation of histone methylation (GO:0031061)3.06350909
108nuclear envelope disassembly (GO:0051081)3.06279842
109membrane disassembly (GO:0030397)3.06279842
110pseudouridine synthesis (GO:0001522)3.05859634
111nucleotide-excision repair, DNA gap filling (GO:0006297)3.05817011
112rRNA methylation (GO:0031167)3.05718464
113nucleobase-containing small molecule interconversion (GO:0015949)3.02325137
114telomere maintenance via telomere lengthening (GO:0010833)3.02225853
115maturation of 5.8S rRNA (GO:0000460)3.01079642
116establishment of protein localization to endoplasmic reticulum (GO:0072599)2.99943803
117electron transport chain (GO:0022900)2.99800720
118cellular protein complex disassembly (GO:0043624)2.99084401
119DNA replication-independent nucleosome assembly (GO:0006336)2.98567028
120DNA replication-independent nucleosome organization (GO:0034724)2.98567028
121L-fucose catabolic process (GO:0042355)2.97518796
122fucose catabolic process (GO:0019317)2.97518796
123L-fucose metabolic process (GO:0042354)2.97518796
124viral life cycle (GO:0019058)2.96480723
125translation (GO:0006412)2.96010260
126centriole replication (GO:0007099)2.95390335
127pteridine-containing compound biosynthetic process (GO:0042559)2.94231695
128cellular component biogenesis (GO:0044085)2.93432353
129positive regulation of ligase activity (GO:0051351)2.93427097
130protein localization to chromosome, centromeric region (GO:0071459)2.93351736
131replication fork processing (GO:0031297)2.92216621
132negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.90064538
133negative regulation of ligase activity (GO:0051352)2.90064538
134mitotic sister chromatid segregation (GO:0000070)2.90055925
135polyketide metabolic process (GO:0030638)2.89233655
136doxorubicin metabolic process (GO:0044598)2.89233655
137daunorubicin metabolic process (GO:0044597)2.89233655
138mitochondrial RNA metabolic process (GO:0000959)2.87550067
139anterograde synaptic vesicle transport (GO:0048490)2.87137942
140cell cycle G1/S phase transition (GO:0044843)2.86858175
141G1/S transition of mitotic cell cycle (GO:0000082)2.86858175
142mitotic G2/M transition checkpoint (GO:0044818)2.86708249
143tRNA processing (GO:0008033)2.86586916
144pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.86193591
145water-soluble vitamin biosynthetic process (GO:0042364)2.84019178
146DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.82901311
147kinetochore assembly (GO:0051382)2.82823151
148somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82701262
149isotype switching (GO:0045190)2.82701262
150somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82701262
151termination of RNA polymerase I transcription (GO:0006363)2.80720693
152RNA methylation (GO:0001510)2.80565876
153aldehyde catabolic process (GO:0046185)2.78747576
154resolution of meiotic recombination intermediates (GO:0000712)2.78113112
155recombinational repair (GO:0000725)2.76794563
156inner mitochondrial membrane organization (GO:0007007)2.76625581
157spindle checkpoint (GO:0031577)2.75931249
158regulation of ubiquitin-protein transferase activity (GO:0051438)2.74900593
159preassembly of GPI anchor in ER membrane (GO:0016254)2.74346397
160double-strand break repair via homologous recombination (GO:0000724)2.74066170
161organelle disassembly (GO:1903008)2.71815207
162establishment of viral latency (GO:0019043)2.70914470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.62204412
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.27302738
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.65070853
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.44799814
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.41901762
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.27768029
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.20653176
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.03476830
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.01457563
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.00597765
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91974922
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.82049551
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.81155251
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.78184800
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.70084974
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.66388953
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.55649771
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.52505539
19VDR_23849224_ChIP-Seq_CD4+_Human2.40859684
20NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31784065
21XRN2_22483619_ChIP-Seq_HELA_Human2.24912702
22ZNF274_21170338_ChIP-Seq_K562_Hela2.23340339
23FOXP3_21729870_ChIP-Seq_TREG_Human2.23271825
24DCP1A_22483619_ChIP-Seq_HELA_Human2.16108359
25SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.12487871
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.07684437
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.04837640
28E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.02802339
29ELK1_19687146_ChIP-ChIP_HELA_Human1.99386118
30ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98498166
31EWS_26573619_Chip-Seq_HEK293_Human1.97643843
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.93978151
33AR_21909140_ChIP-Seq_LNCAP_Human1.92824497
34GABP_19822575_ChIP-Seq_HepG2_Human1.90227332
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.89270065
36FLI1_27457419_Chip-Seq_LIVER_Mouse1.88679155
37FUS_26573619_Chip-Seq_HEK293_Human1.84956729
38MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82637762
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82343282
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81887759
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81680652
42SRF_21415370_ChIP-Seq_HL-1_Mouse1.80896985
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79548610
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.78867165
45THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76479309
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73705074
47VDR_22108803_ChIP-Seq_LS180_Human1.72938336
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72065565
49TTF2_22483619_ChIP-Seq_HELA_Human1.69680128
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.69470500
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.68003611
52CIITA_25753668_ChIP-Seq_RAJI_Human1.67538636
53FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66627872
54E2F1_21310950_ChIP-Seq_MCF-7_Human1.66550197
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.66280160
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64875445
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.64569229
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60916638
59TAF15_26573619_Chip-Seq_HEK293_Human1.54360596
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.49355325
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.47030738
62MYC_22102868_ChIP-Seq_BL_Human1.45978195
63MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.44568234
64HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.43835356
65PCGF2_27294783_Chip-Seq_ESCs_Mouse1.41101868
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.41076412
67IRF1_19129219_ChIP-ChIP_H3396_Human1.41012859
68SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.40067053
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.35690159
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34014175
71KDM5A_27292631_Chip-Seq_BREAST_Human1.28308888
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27573854
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26261056
74IGF1R_20145208_ChIP-Seq_DFB_Human1.25823365
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.24129195
76CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.23743663
77P300_19829295_ChIP-Seq_ESCs_Human1.23097679
78POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22540514
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20991733
80IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.20795955
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20122020
82MYC_18940864_ChIP-ChIP_HL60_Human1.18998716
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17893576
84NANOG_16153702_ChIP-ChIP_HESCs_Human1.16566461
85BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16277776
86CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16044630
87EZH2_27294783_Chip-Seq_NPCs_Mouse1.12240126
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10499777
89TFEB_21752829_ChIP-Seq_HELA_Human1.10021812
90SPI1_23547873_ChIP-Seq_NB4_Human1.09252666
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08968092
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.07674055
93GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07471213
94FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.06973375
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06523706
96TP53_22573176_ChIP-Seq_HFKS_Human1.05991196
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05749406
98FOXA1_25329375_ChIP-Seq_VCAP_Human1.05034946
99FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05034946
100CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.04602808
101KLF4_18555785_ChIP-Seq_MESCs_Mouse1.02687121
102ER_23166858_ChIP-Seq_MCF-7_Human1.01878372
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00702150
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.00393638
105SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97867131
106CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95974108
107HTT_18923047_ChIP-ChIP_STHdh_Human0.95403508
108EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.95184700
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.94998459
110RBPJ_22232070_ChIP-Seq_NCS_Mouse0.93510200
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91077835
112SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.89418927
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89228482
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.88965426
115CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88786822
116ELK1_22589737_ChIP-Seq_MCF10A_Human0.87853439
117CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.87266448
118ZNF263_19887448_ChIP-Seq_K562_Human0.86863754
119SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.86811022
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.86677792
121CTBP2_25329375_ChIP-Seq_LNCAP_Human0.86661651
122FOXA1_21572438_ChIP-Seq_LNCaP_Human0.86030318
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.85658781
124UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.85160534
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84928268
126SALL1_21062744_ChIP-ChIP_HESCs_Human0.84606801
127CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84060458
128MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.83393739
129NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82175533
130CRX_20693478_ChIP-Seq_RETINA_Mouse0.80996035
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80782926
132TP63_19390658_ChIP-ChIP_HaCaT_Human0.80353794
133AR_20517297_ChIP-Seq_VCAP_Human0.79702651
134SOX2_18692474_ChIP-Seq_MEFs_Mouse0.79405831
135CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.78810974
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.76899840
137FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76798806

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41635902
2MP0004957_abnormal_blastocyst_morpholog4.54160659
3MP0010094_abnormal_chromosome_stability4.36713793
4MP0003111_abnormal_nucleus_morphology3.73995734
5MP0003077_abnormal_cell_cycle3.70862763
6MP0008058_abnormal_DNA_repair3.19242678
7MP0008057_abnormal_DNA_replication3.08825101
8MP0003806_abnormal_nucleotide_metabolis2.80580679
9MP0005408_hypopigmentation2.75130416
10MP0002396_abnormal_hematopoietic_system2.71541717
11MP0005075_abnormal_melanosome_morpholog2.60023312
12MP0006072_abnormal_retinal_apoptosis2.53512884
13MP0003718_maternal_effect2.43103832
14MP0002938_white_spotting2.40548789
15MP0008877_abnormal_DNA_methylation2.31363021
16MP0008007_abnormal_cellular_replicative2.25051822
17MP0001730_embryonic_growth_arrest2.24134726
18MP0003123_paternal_imprinting2.17385543
19MP0008932_abnormal_embryonic_tissue2.05308884
20MP0010352_gastrointestinal_tract_polyps2.03363756
21MP0004808_abnormal_hematopoietic_stem2.02473345
22MP0009333_abnormal_splenocyte_physiolog2.01075456
23MP0000490_abnormal_crypts_of1.98679987
24MP0001293_anophthalmia1.97297077
25MP0000350_abnormal_cell_proliferation1.95416707
26MP0003787_abnormal_imprinting1.92470076
27MP0003763_abnormal_thymus_physiology1.80496749
28MP0005397_hematopoietic_system_phenotyp1.76566369
29MP0001545_abnormal_hematopoietic_system1.76566369
30MP0005253_abnormal_eye_physiology1.75824019
31MP0005084_abnormal_gallbladder_morpholo1.71256104
32MP0006292_abnormal_olfactory_placode1.68725921
33MP0002102_abnormal_ear_morphology1.67931504
34MP0003890_abnormal_embryonic-extraembry1.66726595
35MP0003786_premature_aging1.66498983
36MP0001529_abnormal_vocalization1.64503046
37MP0002736_abnormal_nociception_after1.63404820
38MP0008789_abnormal_olfactory_epithelium1.63248348
39MP0002398_abnormal_bone_marrow1.62542757
40MP0006036_abnormal_mitochondrial_physio1.62240437
41MP0000689_abnormal_spleen_morphology1.61787454
42MP0010307_abnormal_tumor_latency1.61421534
43MP0002722_abnormal_immune_system1.56752229
44MP0002019_abnormal_tumor_incidence1.56446501
45MP0006054_spinal_hemorrhage1.51459318
46MP0000703_abnormal_thymus_morphology1.50524358
47MP0004084_abnormal_cardiac_muscle1.49236254
48MP0008995_early_reproductive_senescence1.48834588
49MP0002080_prenatal_lethality1.45029550
50MP0001697_abnormal_embryo_size1.44814977
51MP0001672_abnormal_embryogenesis/_devel1.41287141
52MP0005380_embryogenesis_phenotype1.41287141
53MP0003567_abnormal_fetal_cardiomyocyte1.39852059
54MP0001984_abnormal_olfaction1.39274379
55MP0000313_abnormal_cell_death1.39234635
56MP0003195_calcinosis1.37710096
57MP0001919_abnormal_reproductive_system1.32734128
58MP0003011_delayed_dark_adaptation1.31448724
59MP0005174_abnormal_tail_pigmentation1.31376809
60MP0000516_abnormal_urinary_system1.29793202
61MP0005367_renal/urinary_system_phenotyp1.29793202
62MP0001485_abnormal_pinna_reflex1.29557839
63MP0003984_embryonic_growth_retardation1.29166492
64MP0000631_abnormal_neuroendocrine_gland1.27527515
65MP0005551_abnormal_eye_electrophysiolog1.27205497
66MP0000372_irregular_coat_pigmentation1.24993061
67MP0003656_abnormal_erythrocyte_physiolo1.24753819
68MP0002088_abnormal_embryonic_growth/wei1.23303563
69MP0002086_abnormal_extraembryonic_tissu1.22762452
70MP0002837_dystrophic_cardiac_calcinosis1.20974643
71MP0002429_abnormal_blood_cell1.20718742
72MP0001324_abnormal_eye_pigmentation1.19899668
73MP0003186_abnormal_redox_activity1.17906146
74MP0005671_abnormal_response_to1.17429033
75MP0003943_abnormal_hepatobiliary_system1.16109677
76MP0003252_abnormal_bile_duct1.13741641
77MP0004133_heterotaxia1.11993088
78MP0001800_abnormal_humoral_immune1.10550396
79MP0002751_abnormal_autonomic_nervous1.10314345
80MP0003121_genomic_imprinting1.10167872
81MP0000716_abnormal_immune_system1.09760383
82MP0002090_abnormal_vision1.09160408
83MP0001764_abnormal_homeostasis1.08330273
84MP0005394_taste/olfaction_phenotype1.07696614
85MP0005499_abnormal_olfactory_system1.07696614
86MP0009379_abnormal_foot_pigmentation1.06895008
87MP0001968_abnormal_touch/_nociception1.06808297
88MP0003937_abnormal_limbs/digits/tail_de1.05727083
89MP0002085_abnormal_embryonic_tissue1.03981145
90MP0003300_gastrointestinal_ulcer1.02814555
91MP0003880_abnormal_central_pattern1.02232844
92MP0002877_abnormal_melanocyte_morpholog1.02167563
93MP0005391_vision/eye_phenotype1.02005399
94MP0000465_gastrointestinal_hemorrhage1.01643524
95MP0009785_altered_susceptibility_to1.00184251
96MP0002132_abnormal_respiratory_system0.99402388
97MP0002084_abnormal_developmental_patter0.97618818
98MP0002277_abnormal_respiratory_mucosa0.96506976
99MP0005389_reproductive_system_phenotype0.96308958
100MP0002210_abnormal_sex_determination0.95816251
101MP0000569_abnormal_digit_pigmentation0.95148995
102MP0002420_abnormal_adaptive_immunity0.93465985
103MP0002095_abnormal_skin_pigmentation0.90382980
104MP0008875_abnormal_xenobiotic_pharmacok0.90368842
105MP0001145_abnormal_male_reproductive0.90265793
106MP0005410_abnormal_fertilization0.89169981
107MP0006035_abnormal_mitochondrial_morpho0.88769668
108MP0003941_abnormal_skin_development0.88693517
109MP0001819_abnormal_immune_cell0.88685967
110MP0008872_abnormal_physiological_respon0.88260891
111MP0000477_abnormal_intestine_morphology0.87112411
112MP0003724_increased_susceptibility_to0.87046850
113MP0003221_abnormal_cardiomyocyte_apopto0.86005111
114MP0000858_altered_metastatic_potential0.85646050
115MP0003698_abnormal_male_reproductive0.85450880
116MP0000371_diluted_coat_color0.85361688
117MP0002723_abnormal_immune_serum0.84979309
118MP0002160_abnormal_reproductive_system0.84162971
119MP0000566_synostosis0.83686126
120MP0002928_abnormal_bile_duct0.82780329
121MP0000653_abnormal_sex_gland0.82043617
122MP0000358_abnormal_cell_content/0.81351644
123MP0002075_abnormal_coat/hair_pigmentati0.80193538
124MP0004885_abnormal_endolymph0.80048896
125MP0001929_abnormal_gametogenesis0.79529483
126MP0009697_abnormal_copulation0.79323011
127MP0002452_abnormal_antigen_presenting0.79140622
128MP0010155_abnormal_intestine_physiology0.78983141
129MP0004197_abnormal_fetal_growth/weight/0.77467385
130MP0003866_abnormal_defecation0.77047094
131MP0000598_abnormal_liver_morphology0.77009764
132MP0001119_abnormal_female_reproductive0.76672950
133MP0004215_abnormal_myocardial_fiber0.75176927
134MP0005266_abnormal_metabolism0.75064953
135MP0004147_increased_porphyrin_level0.74842080
136MP0000015_abnormal_ear_pigmentation0.74600911
137MP0002234_abnormal_pharynx_morphology0.72646394
138MP0005464_abnormal_platelet_physiology0.72596063
139MP0003315_abnormal_perineum_morphology0.72359848
140MP0001186_pigmentation_phenotype0.72152905
141MP0010234_abnormal_vibrissa_follicle0.71382916
142MP0001915_intracranial_hemorrhage0.70676140
143MP0005332_abnormal_amino_acid0.70109012
144MP0005000_abnormal_immune_tolerance0.69719993
145MP0003436_decreased_susceptibility_to0.69062459
146MP0001835_abnormal_antigen_presentation0.68814926
147MP0005384_cellular_phenotype0.66092760
148MP0000049_abnormal_middle_ear0.65515860
149MP0008469_abnormal_protein_level0.65484111
150MP0005646_abnormal_pituitary_gland0.65374913
151MP0004036_abnormal_muscle_relaxation0.64472789
152MP0005195_abnormal_posterior_eye0.62619224
153MP0002254_reproductive_system_inflammat0.62173811
154MP0002166_altered_tumor_susceptibility0.61665994
155MP0005645_abnormal_hypothalamus_physiol0.61521401
156MP0002233_abnormal_nose_morphology0.60935597
157MP0005395_other_phenotype0.60398129
158MP0005621_abnormal_cell_physiology0.59909002

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.24423594
2Abnormality of cells of the erythroid lineage (HP:0012130)4.45906934
3Breast hypoplasia (HP:0003187)4.34987287
4Abnormal number of erythroid precursors (HP:0012131)4.30629944
5Visual hallucinations (HP:0002367)4.05004515
6Absent thumb (HP:0009777)4.04741882
7Aplastic anemia (HP:0001915)4.03167329
8Amyotrophic lateral sclerosis (HP:0007354)3.60587291
9Reticulocytopenia (HP:0001896)3.57331429
10Distal arthrogryposis (HP:0005684)3.53708177
11Ankle contracture (HP:0006466)3.45194033
12Atrophy/Degeneration involving motor neurons (HP:0007373)3.39114945
13Thrombocytosis (HP:0001894)3.38345768
14Aplasia/Hypoplasia of the sternum (HP:0006714)3.25703910
15Acute encephalopathy (HP:0006846)3.25392212
16Myelodysplasia (HP:0002863)3.17806852
173-Methylglutaconic aciduria (HP:0003535)3.14169290
18Abnormality of the distal phalanges of the toes (HP:0010182)3.10766627
19Methylmalonic acidemia (HP:0002912)3.09128763
20B lymphocytopenia (HP:0010976)3.08117189
21Glossoptosis (HP:0000162)3.02535939
22Progressive macrocephaly (HP:0004481)3.01806965
23Colon cancer (HP:0003003)2.98013668
24IgM deficiency (HP:0002850)2.96625271
25Basal cell carcinoma (HP:0002671)2.94300635
26Methylmalonic aciduria (HP:0012120)2.90744038
27Agnosia (HP:0010524)2.87144164
28Oral leukoplakia (HP:0002745)2.87081016
29Aplasia/Hypoplasia of the sacrum (HP:0008517)2.81225062
30Abnormality of B cell number (HP:0010975)2.81029124
31Chromsome breakage (HP:0040012)2.77570330
32Renal Fanconi syndrome (HP:0001994)2.74430546
33Broad alveolar ridges (HP:0000187)2.72418365
34Abnormality of the anterior horn cell (HP:0006802)2.70676508
35Degeneration of anterior horn cells (HP:0002398)2.70676508
36Abnormality of serum amino acid levels (HP:0003112)2.68528716
37Increased serum lactate (HP:0002151)2.64894119
38Increased intramyocellular lipid droplets (HP:0012240)2.64042876
39Macrocytic anemia (HP:0001972)2.62873143
40Patellar aplasia (HP:0006443)2.61486626
41Ependymoma (HP:0002888)2.57104304
42Hepatic necrosis (HP:0002605)2.54032157
43Hypoplastic pelvis (HP:0008839)2.53589616
44Cerebral edema (HP:0002181)2.52833423
45Pallor (HP:0000980)2.51672298
46Hepatocellular necrosis (HP:0001404)2.48557015
47Microvesicular hepatic steatosis (HP:0001414)2.48146075
48Microretrognathia (HP:0000308)2.47701711
49Abnormality of aspartate family amino acid metabolism (HP:0010899)2.47537508
50Rough bone trabeculation (HP:0100670)2.46834157
51Septo-optic dysplasia (HP:0100842)2.46237217
52Axonal loss (HP:0003447)2.43380729
53Pancreatic cysts (HP:0001737)2.38999303
54Abnormal lung lobation (HP:0002101)2.38988873
55Aplasia/Hypoplasia of the patella (HP:0006498)2.38082449
56Amaurosis fugax (HP:0100576)2.37024289
57Pancytopenia (HP:0001876)2.34841523
58Abnormality of the preputium (HP:0100587)2.33405532
59Abnormality of midbrain morphology (HP:0002418)2.33214248
60Molar tooth sign on MRI (HP:0002419)2.33214248
61Sparse eyelashes (HP:0000653)2.32942040
62Abnormality of methionine metabolism (HP:0010901)2.32863877
63Pancreatic fibrosis (HP:0100732)2.32745493
64True hermaphroditism (HP:0010459)2.32495503
65Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.31099863
66Decreased activity of mitochondrial respiratory chain (HP:0008972)2.31099863
67Increased hepatocellular lipid droplets (HP:0006565)2.28972279
68Gonadotropin excess (HP:0000837)2.28669582
69Oligodactyly (hands) (HP:0001180)2.28464264
70Bone marrow hypocellularity (HP:0005528)2.27621311
71Medulloblastoma (HP:0002885)2.27601273
72Increased CSF lactate (HP:0002490)2.23708426
73Abnormality of chromosome stability (HP:0003220)2.23521837
74Adactyly (HP:0009776)2.22732893
75Carpal bone hypoplasia (HP:0001498)2.21440818
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.21098133
77Nephronophthisis (HP:0000090)2.19044987
78Peripheral hypomyelination (HP:0007182)2.18345668
79Abnormal neuron morphology (HP:0012757)2.16350437
80Abnormality of the motor neurons (HP:0002450)2.16350437
81Medial flaring of the eyebrow (HP:0010747)2.14604329
82Chromosomal breakage induced by crosslinking agents (HP:0003221)2.14587421
83Sparse scalp hair (HP:0002209)2.13869218
84Premature graying of hair (HP:0002216)2.12782079
85Mitochondrial inheritance (HP:0001427)2.12437701
86IgG deficiency (HP:0004315)2.10847100
87Multiple enchondromatosis (HP:0005701)2.09376778
88Lipid accumulation in hepatocytes (HP:0006561)2.08027771
89Aplasia/hypoplasia of the uterus (HP:0008684)2.07989157
9011 pairs of ribs (HP:0000878)2.07932662
91Cerebral hypomyelination (HP:0006808)2.07851639
92Exertional dyspnea (HP:0002875)2.06445774
93Abnormality of pyrimidine metabolism (HP:0004353)2.05934178
94Supernumerary spleens (HP:0009799)2.05458893
95Slender long bone (HP:0003100)2.04616665
96Meckel diverticulum (HP:0002245)2.03835022
97Posterior subcapsular cataract (HP:0007787)2.03641760
98Bile duct proliferation (HP:0001408)2.03381077
99Abnormal biliary tract physiology (HP:0012439)2.03381077
100Neoplasm of the pancreas (HP:0002894)2.03281863
101Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.00734530
102Cellular immunodeficiency (HP:0005374)1.99856088
103Increased muscle lipid content (HP:0009058)1.98580679
104Congenital primary aphakia (HP:0007707)1.97827072
105Impulsivity (HP:0100710)1.96023760
106Lactic acidosis (HP:0003128)1.95954785
107Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.95357082
108Lymphoma (HP:0002665)1.95104701
109Exercise intolerance (HP:0003546)1.94433019
110Abnormality of the duodenum (HP:0002246)1.93396452
111Congenital, generalized hypertrichosis (HP:0004540)1.93112219
112Chronic hepatic failure (HP:0100626)1.92942967
113Respiratory difficulties (HP:0002880)1.92060099
114Asplenia (HP:0001746)1.91850422
115Rhabdomyosarcoma (HP:0002859)1.91741884
116Renal cortical cysts (HP:0000803)1.91447285
117Respiratory failure (HP:0002878)1.91164889
118Nephrogenic diabetes insipidus (HP:0009806)1.91052916
119Abnormality of T cell physiology (HP:0011840)1.90806194
120Intestinal atresia (HP:0011100)1.90632631
121Abnormality of the heme biosynthetic pathway (HP:0010472)1.89872235
122Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.89823861
123Abnormality of alanine metabolism (HP:0010916)1.89823861
124Hyperalaninemia (HP:0003348)1.89823861
125Abnormality of the labia minora (HP:0012880)1.89191260
126Poikiloderma (HP:0001029)1.89083651
127Absent septum pellucidum (HP:0001331)1.88783221
128Lethargy (HP:0001254)1.87989411
129Hypoplasia of the pons (HP:0012110)1.87070943
130Acute necrotizing encephalopathy (HP:0006965)1.86567872
131Aplasia/Hypoplasia of the uvula (HP:0010293)1.86492423
132Abnormality of the alveolar ridges (HP:0006477)1.86466355
133Abnormal mitochondria in muscle tissue (HP:0008316)1.85989046
134Gait imbalance (HP:0002141)1.85553205
135Type I transferrin isoform profile (HP:0003642)1.85372951
136Duodenal stenosis (HP:0100867)1.84785188
137Small intestinal stenosis (HP:0012848)1.84785188
138Severe global developmental delay (HP:0011344)1.84732952
139Abnormality of the pons (HP:0007361)1.84682954
140Optic disc pallor (HP:0000543)1.84536257
141Hyperglycinemia (HP:0002154)1.84502128
142Abnormality of T cells (HP:0002843)1.84494554
143Decreased skull ossification (HP:0004331)1.83250279
144CNS demyelination (HP:0007305)1.83193333
145Abnormality of the ileum (HP:0001549)1.81081426
146Volvulus (HP:0002580)1.80724499
147Leukodystrophy (HP:0002415)1.79628545
148Hyperphosphaturia (HP:0003109)1.79264603
149Abnormality of glycolysis (HP:0004366)1.78493989
150Increased serum pyruvate (HP:0003542)1.78493989
151Sloping forehead (HP:0000340)1.76247674
152Abnormality of renal resorption (HP:0011038)1.75893071
153Abnormal protein glycosylation (HP:0012346)1.75593344
154Abnormal glycosylation (HP:0012345)1.75593344
155Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75593344
156Abnormal protein N-linked glycosylation (HP:0012347)1.75593344
157Triphalangeal thumb (HP:0001199)1.74854055
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74405979
159Median cleft lip (HP:0000161)1.74266519
160Homocystinuria (HP:0002156)1.72365987
161Abnormality of homocysteine metabolism (HP:0010919)1.72365987
162Optic nerve hypoplasia (HP:0000609)1.71591737

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.36907544
2WEE14.05415296
3PIK3CG3.85964567
4CDC73.45196514
5EIF2AK13.33141012
6TRIM282.89079762
7STK162.72292886
8TSSK62.70054192
9WNK32.57610037
10NUAK12.49856619
11VRK22.49242640
12ACVR1B2.25057829
13MKNK12.19036231
14SRPK12.17859852
15BRSK22.10197433
16RPS6KA42.07626141
17PBK2.05317545
18NEK21.93247143
19FRK1.93197997
20VRK11.90515406
21EIF2AK31.87246374
22TNIK1.84694190
23TTK1.83133490
24CSNK1G11.77547399
25FLT31.73256256
26PASK1.72983955
27PLK11.65215521
28BMPR1B1.64767956
29NME21.62891755
30PLK31.62565579
31NEK11.60470848
32NLK1.58108976
33MAP4K11.57349639
34STK101.54824312
35CASK1.53036466
36TGFBR11.48961545
37TESK21.45915346
38ADRBK21.44249301
39PLK41.42184526
40AURKB1.40528974
41AKT31.38879538
42CCNB11.38664551
43RPS6KB21.35708495
44MAP3K121.34109965
45CSNK1G31.33815058
46BCKDK1.28958908
47ERBB31.27789198
48BRAF1.26831249
49ATR1.26051513
50MAP3K81.24925716
51CHEK21.21396262
52CSNK1G21.20927796
53GRK11.19295864
54DYRK31.18093251
55CSNK1A1L1.12336684
56CDK71.12244267
57AURKA1.11062402
58MAP2K31.10320504
59KIT1.05035880
60PRKCI1.02120443
61PDK21.01083829
62MKNK20.99678317
63MAP4K20.98201205
64BRSK10.97799386
65BCR0.95573638
66INSRR0.95342244
67TLK10.92703525
68IKBKE0.92237896
69BTK0.89016199
70PIM10.88415221
71YES10.88115620
72TAF10.86943256
73STK40.86458364
74PAK40.85709641
75GRK60.85649225
76TEC0.83221807
77CSNK2A20.82733973
78PKN20.80583609
79SCYL20.76357097
80DYRK20.76338873
81DAPK10.73349318
82MAPK130.71706708
83CHEK10.71409567
84CDK40.71208033
85STK30.70129980
86PLK20.69391705
87CSNK2A10.67170221
88MAP3K40.66606980
89RPS6KA50.65914123
90TXK0.63611371
91TYK20.61832779
92ALK0.60885579
93LRRK20.59906200
94CDK20.58201851
95ZAK0.58130436
96ATM0.57479447
97TAOK30.55758277
98PRKCG0.55270357
99IKBKB0.55014073
100MAP2K70.54985473
101PINK10.54872064
102OXSR10.54590267
103TNK20.54084916
104PRKCE0.52988713
105MAP3K30.52607490
106ARAF0.52605867
107LYN0.50422456
108CDK190.50230693
109MELK0.50215529
110NME10.48148582
111SYK0.47806664
112EPHA20.47056227
113PRKCQ0.46077396
114CDK80.44497171
115MAPKAPK30.43950269
116CDK10.43871905
117CDK120.43522220
118ZAP700.40755172
119EIF2AK20.39730090
120KDR0.39557411
121JAK30.38274208
122CSNK1A10.37730803
123MUSK0.37667661
124MST40.37555331
125LIMK10.37282962
126STK38L0.37124929
127PAK10.36993409
128MAP3K110.35884972
129MAP2K60.35858902
130GRK70.34763012
131CDK60.34746540
132MYLK0.34237409
133CAMKK20.33914855
134SIK30.33661374
135EEF2K0.30209526
136SGK20.29174570
137STK390.28715939
138BMPR20.28008465
139ADRBK10.26812520
140CDK90.26608390
141MAPK110.24979510
142STK240.23521705
143CSNK1E0.23053917
144ERBB40.23018787
145MAP3K90.22670108
146PRKCA0.21574141
147WNK40.21500591

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.43096571
2Mismatch repair_Homo sapiens_hsa034304.33251500
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.87443948
4Ribosome_Homo sapiens_hsa030103.78742061
5RNA polymerase_Homo sapiens_hsa030203.69000013
6Proteasome_Homo sapiens_hsa030503.64383502
7Spliceosome_Homo sapiens_hsa030403.03114528
8RNA transport_Homo sapiens_hsa030132.89420520
9Base excision repair_Homo sapiens_hsa034102.86439686
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.85495145
11Pyrimidine metabolism_Homo sapiens_hsa002402.79103901
12Nucleotide excision repair_Homo sapiens_hsa034202.75500165
13Homologous recombination_Homo sapiens_hsa034402.56372543
14Cell cycle_Homo sapiens_hsa041102.40624040
15One carbon pool by folate_Homo sapiens_hsa006702.31478224
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.15352217
17Non-homologous end-joining_Homo sapiens_hsa034502.15269114
18RNA degradation_Homo sapiens_hsa030182.00205930
19Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.72274499
20Steroid biosynthesis_Homo sapiens_hsa001001.70348202
21Fanconi anemia pathway_Homo sapiens_hsa034601.66875174
22Basal transcription factors_Homo sapiens_hsa030221.58812408
23Purine metabolism_Homo sapiens_hsa002301.54659889
24Folate biosynthesis_Homo sapiens_hsa007901.51736935
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40515136
26p53 signaling pathway_Homo sapiens_hsa041151.34489157
27Protein export_Homo sapiens_hsa030601.32781179
28Fatty acid elongation_Homo sapiens_hsa000621.27804560
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27616677
30Cysteine and methionine metabolism_Homo sapiens_hsa002701.27033565
31Sulfur metabolism_Homo sapiens_hsa009201.22057004
32Epstein-Barr virus infection_Homo sapiens_hsa051691.18738919
33Butanoate metabolism_Homo sapiens_hsa006501.12969371
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.07034500
35Pentose phosphate pathway_Homo sapiens_hsa000301.05360782
36Parkinsons disease_Homo sapiens_hsa050121.04297242
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02665487
38mRNA surveillance pathway_Homo sapiens_hsa030151.00567988
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.99043189
40Antigen processing and presentation_Homo sapiens_hsa046120.98343578
41Biosynthesis of amino acids_Homo sapiens_hsa012300.96106875
42Caffeine metabolism_Homo sapiens_hsa002320.95602123
43Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94334178
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.92504880
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88104570
46Huntingtons disease_Homo sapiens_hsa050160.86966890
47Oxidative phosphorylation_Homo sapiens_hsa001900.83070422
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81477312
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.81138766
50Selenocompound metabolism_Homo sapiens_hsa004500.80198457
51Carbon metabolism_Homo sapiens_hsa012000.79683689
52Maturity onset diabetes of the young_Homo sapiens_hsa049500.77356390
53Systemic lupus erythematosus_Homo sapiens_hsa053220.75442059
54Phototransduction_Homo sapiens_hsa047440.75408046
55Nitrogen metabolism_Homo sapiens_hsa009100.75152214
56Viral carcinogenesis_Homo sapiens_hsa052030.74235495
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.70756215
58Oocyte meiosis_Homo sapiens_hsa041140.69963552
59Sulfur relay system_Homo sapiens_hsa041220.69689944
60Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69302782
61Primary immunodeficiency_Homo sapiens_hsa053400.65507866
62Herpes simplex infection_Homo sapiens_hsa051680.63187718
63Glutathione metabolism_Homo sapiens_hsa004800.63086104
64Legionellosis_Homo sapiens_hsa051340.61670849
65Collecting duct acid secretion_Homo sapiens_hsa049660.61317427
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61223492
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59797583
68Fructose and mannose metabolism_Homo sapiens_hsa000510.58569050
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.58450214
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57985836
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54608222
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52611745
73Vitamin B6 metabolism_Homo sapiens_hsa007500.52433389
74Galactose metabolism_Homo sapiens_hsa000520.51846632
75Primary bile acid biosynthesis_Homo sapiens_hsa001200.49834511
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.48267471
77Chemical carcinogenesis_Homo sapiens_hsa052040.47543941
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47518245
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47245236
80Linoleic acid metabolism_Homo sapiens_hsa005910.46104496
81Regulation of autophagy_Homo sapiens_hsa041400.45812861
82Retinol metabolism_Homo sapiens_hsa008300.45157664
83beta-Alanine metabolism_Homo sapiens_hsa004100.44596047
84Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44433432
85Cardiac muscle contraction_Homo sapiens_hsa042600.43977152
86Metabolic pathways_Homo sapiens_hsa011000.42766129
87Pyruvate metabolism_Homo sapiens_hsa006200.42203540
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.41618824
89Tryptophan metabolism_Homo sapiens_hsa003800.41607225
90Ether lipid metabolism_Homo sapiens_hsa005650.41131408
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40300169
92Thyroid cancer_Homo sapiens_hsa052160.39360314
93Measles_Homo sapiens_hsa051620.38787536
94Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38669938
95RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38241799
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.37192756
97Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.34089930
98Fatty acid metabolism_Homo sapiens_hsa012120.33369701
99Hepatitis B_Homo sapiens_hsa051610.32738840
100Vitamin digestion and absorption_Homo sapiens_hsa049770.32640677
101Alzheimers disease_Homo sapiens_hsa050100.31875947
102HTLV-I infection_Homo sapiens_hsa051660.31121528
103Steroid hormone biosynthesis_Homo sapiens_hsa001400.28124350
104Olfactory transduction_Homo sapiens_hsa047400.28038848
105Circadian rhythm_Homo sapiens_hsa047100.27998322
106Fatty acid degradation_Homo sapiens_hsa000710.27483178
107Transcriptional misregulation in cancer_Homo sapiens_hsa052020.27129707
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27074725
109Hematopoietic cell lineage_Homo sapiens_hsa046400.26047222
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.25580091
111Small cell lung cancer_Homo sapiens_hsa052220.25058243
112Acute myeloid leukemia_Homo sapiens_hsa052210.24375612
113Apoptosis_Homo sapiens_hsa042100.22536884
114HIF-1 signaling pathway_Homo sapiens_hsa040660.21372974
115Arginine and proline metabolism_Homo sapiens_hsa003300.20932379
116Arachidonic acid metabolism_Homo sapiens_hsa005900.20755762
117Other glycan degradation_Homo sapiens_hsa005110.19311952
118Shigellosis_Homo sapiens_hsa051310.19148372
119Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.17474094
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.17458679
121Colorectal cancer_Homo sapiens_hsa052100.16816990
122Alcoholism_Homo sapiens_hsa050340.16420333
123N-Glycan biosynthesis_Homo sapiens_hsa005100.15995763
124Intestinal immune network for IgA production_Homo sapiens_hsa046720.13482039
125Propanoate metabolism_Homo sapiens_hsa006400.11480341
126B cell receptor signaling pathway_Homo sapiens_hsa046620.10563366
127Influenza A_Homo sapiens_hsa051640.10356380
128Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.07511507
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05422661
130Non-small cell lung cancer_Homo sapiens_hsa052230.04334539
131Type I diabetes mellitus_Homo sapiens_hsa049400.03374324
132Peroxisome_Homo sapiens_hsa041460.02471595
133Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.02460469
134NF-kappa B signaling pathway_Homo sapiens_hsa040640.02035969

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