METTL21A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.39233213
2ribosomal small subunit assembly (GO:0000028)5.96665197
3L-fucose catabolic process (GO:0042355)5.14100285
4fucose catabolic process (GO:0019317)5.14100285
5L-fucose metabolic process (GO:0042354)5.14100285
6regulation of posttranscriptional gene silencing (GO:0060147)5.05085134
7regulation of gene silencing by miRNA (GO:0060964)5.05085134
8regulation of gene silencing by RNA (GO:0060966)5.05085134
9viral transcription (GO:0019083)4.98857229
10kynurenine metabolic process (GO:0070189)4.94924691
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.92870559
12indole-containing compound catabolic process (GO:0042436)4.90913784
13indolalkylamine catabolic process (GO:0046218)4.90913784
14tryptophan catabolic process (GO:0006569)4.90913784
15cotranslational protein targeting to membrane (GO:0006613)4.89016786
16protein targeting to ER (GO:0045047)4.82743576
17translational termination (GO:0006415)4.80042387
18ribosomal small subunit biogenesis (GO:0042274)4.62790880
19protein localization to endoplasmic reticulum (GO:0070972)4.57298362
20establishment of protein localization to endoplasmic reticulum (GO:0072599)4.55328693
21indolalkylamine metabolic process (GO:0006586)4.45508170
22maturation of SSU-rRNA (GO:0030490)4.40977810
23regulation of hippo signaling (GO:0035330)4.35256048
24DNA deamination (GO:0045006)4.33901219
25translational elongation (GO:0006414)4.32447290
26proteasome assembly (GO:0043248)4.30322507
27tryptophan metabolic process (GO:0006568)4.20037760
28L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.09818993
29regulation of translation, ncRNA-mediated (GO:0045974)4.07965642
30negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.07965642
31negative regulation of translation, ncRNA-mediated (GO:0040033)4.07965642
32cullin deneddylation (GO:0010388)4.03001785
33daunorubicin metabolic process (GO:0044597)4.02817978
34polyketide metabolic process (GO:0030638)4.02817978
35doxorubicin metabolic process (GO:0044598)4.02817978
36NADH dehydrogenase complex assembly (GO:0010257)3.89560497
37mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.89560497
38mitochondrial respiratory chain complex I assembly (GO:0032981)3.89560497
39oxidative demethylation (GO:0070989)3.88715365
40telomere maintenance via telomerase (GO:0007004)3.86957294
41viral life cycle (GO:0019058)3.83301278
42snRNA transcription (GO:0009301)3.80482126
43translation (GO:0006412)3.79701744
44RNA-dependent DNA replication (GO:0006278)3.79250817
45positive regulation of interleukin-8 secretion (GO:2000484)3.75843159
46sulfation (GO:0051923)3.72802152
47cellular protein complex disassembly (GO:0043624)3.72549818
48protein deneddylation (GO:0000338)3.71008286
49translational initiation (GO:0006413)3.67912119
50deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.66693067
51negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.61917874
52regulation of nuclear cell cycle DNA replication (GO:0033262)3.61345857
53indole-containing compound metabolic process (GO:0042430)3.58729677
54transcription elongation from RNA polymerase III promoter (GO:0006385)3.58727812
55termination of RNA polymerase III transcription (GO:0006386)3.58727812
56regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.58235411
57protein complex biogenesis (GO:0070271)3.56905844
58protein neddylation (GO:0045116)3.54459538
59cellular response to ATP (GO:0071318)3.51878167
60antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.48097139
61formation of translation preinitiation complex (GO:0001731)3.44501161
62detection of light stimulus involved in sensory perception (GO:0050962)3.43026403
63detection of light stimulus involved in visual perception (GO:0050908)3.43026403
64nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.41446188
65gamma-aminobutyric acid transport (GO:0015812)3.39996233
66regulation of interleukin-8 secretion (GO:2000482)3.39945537
67regulation of mesoderm development (GO:2000380)3.37097303
68purine nucleobase biosynthetic process (GO:0009113)3.36843960
69NAD biosynthetic process (GO:0009435)3.36360685
70primary amino compound metabolic process (GO:1901160)3.36344304
71cellular ketone body metabolic process (GO:0046950)3.29542922
72interkinetic nuclear migration (GO:0022027)3.28609084
73negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.27422669
74negative regulation of ligase activity (GO:0051352)3.27422669
75DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.26940123
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26039033
77serotonin metabolic process (GO:0042428)3.24468282
78signal peptide processing (GO:0006465)3.24397833
79antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.24098907
80mitochondrial respiratory chain complex assembly (GO:0033108)3.23112004
81regulation of cellular amino acid metabolic process (GO:0006521)3.22503459
82protein maturation by protein folding (GO:0022417)3.22101665
83ATP synthesis coupled proton transport (GO:0015986)3.21591076
84energy coupled proton transport, down electrochemical gradient (GO:0015985)3.21591076
85amino acid salvage (GO:0043102)3.21383023
86L-methionine salvage (GO:0071267)3.21383023
87L-methionine biosynthetic process (GO:0071265)3.21383023
88ribonucleoprotein complex biogenesis (GO:0022613)3.19910227
89protein targeting to membrane (GO:0006612)3.19634748
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.19059511
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.19059511
92ribosomal large subunit biogenesis (GO:0042273)3.18468520
93signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.16319252
94signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.16319252
95signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.16319252
96regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.13881398
97DNA methylation involved in gamete generation (GO:0043046)3.12222091
98nucleobase-containing small molecule interconversion (GO:0015949)3.10953680
99CTP metabolic process (GO:0046036)3.09579187
100CTP biosynthetic process (GO:0006241)3.09579187
101flavonoid metabolic process (GO:0009812)3.09325353
102reciprocal DNA recombination (GO:0035825)3.07734096
103reciprocal meiotic recombination (GO:0007131)3.07734096
104nucleobase biosynthetic process (GO:0046112)3.07555107
105neuronal action potential (GO:0019228)3.07187369
106cellular component biogenesis (GO:0044085)3.06973281
107positive regulation of CREB transcription factor activity (GO:0032793)3.06583160
108positive regulation of fatty acid oxidation (GO:0046321)3.05767215
109mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.05728315
110peptidyl-histidine modification (GO:0018202)3.05531386
111drug catabolic process (GO:0042737)3.03818348
112cellular response to exogenous dsRNA (GO:0071360)3.01649665
113protein import into peroxisome matrix (GO:0016558)3.01284559
114protein complex disassembly (GO:0043241)3.00040323
115signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99780391
116signal transduction involved in DNA damage checkpoint (GO:0072422)2.99780391
117amine catabolic process (GO:0009310)2.99037075
118cellular biogenic amine catabolic process (GO:0042402)2.99037075
119viral mRNA export from host cell nucleus (GO:0046784)2.97221566
120macromolecular complex disassembly (GO:0032984)2.96212931
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.95084205
122aromatic amino acid family catabolic process (GO:0009074)2.95028905
123rRNA catabolic process (GO:0016075)2.94817190
124oxidative phosphorylation (GO:0006119)2.94654216
125protein K48-linked deubiquitination (GO:0071108)2.94589725
126maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.92545583
127piRNA metabolic process (GO:0034587)2.91742502
128signal transduction involved in cell cycle checkpoint (GO:0072395)2.91011274
129protein retention in ER lumen (GO:0006621)2.89976218
130RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.89750345
131tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.89750345
132guanosine-containing compound biosynthetic process (GO:1901070)2.89100185
133ketone body metabolic process (GO:1902224)2.88919502
134detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.88250913
135nonmotile primary cilium assembly (GO:0035058)2.87672779
136peristalsis (GO:0030432)2.87374745
137negative regulation of mast cell activation (GO:0033004)2.86402089
138cornea development in camera-type eye (GO:0061303)2.86377855
139protein targeting to mitochondrion (GO:0006626)2.86047041
140chondrocyte proliferation (GO:0035988)2.85769804
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.85411897
142positive regulation of developmental pigmentation (GO:0048087)2.85349640
143respiratory chain complex IV assembly (GO:0008535)2.84972227
144pseudouridine synthesis (GO:0001522)2.84718801
145negative regulation of telomere maintenance (GO:0032205)2.84229152
146positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84197891
147negative regulation of systemic arterial blood pressure (GO:0003085)2.84029780
148endosome to melanosome transport (GO:0035646)2.83307376
149endosome to pigment granule transport (GO:0043485)2.83307376
1507-methylguanosine mRNA capping (GO:0006370)2.82667045
1517-methylguanosine RNA capping (GO:0009452)2.81348464
152RNA capping (GO:0036260)2.81348464
153regulation of pigment cell differentiation (GO:0050932)2.81230976
154nucleotide transmembrane transport (GO:1901679)2.79846356
155regulation of mitochondrial translation (GO:0070129)2.79085167
156establishment of protein localization to mitochondrion (GO:0072655)2.78283603
157DNA strand elongation (GO:0022616)2.77414449
158membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.76392629
159fucose metabolic process (GO:0006004)2.76023693
160endoderm formation (GO:0001706)2.75739543
161positive regulation of ligase activity (GO:0051351)2.75473840
162histone-serine phosphorylation (GO:0035404)2.75283676
163regulation of action potential (GO:0098900)2.75124648
164fucosylation (GO:0036065)2.74947915
165negative regulation of synaptic transmission, GABAergic (GO:0032229)2.73908586
166positive regulation of fatty acid transport (GO:2000193)2.72828465
167negative regulation of sodium ion transport (GO:0010766)2.70950879
168neurotransmitter metabolic process (GO:0042133)2.69375282
169G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.68147464
170spinal cord motor neuron differentiation (GO:0021522)2.63682401
171RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63349797
172negative regulation of reactive oxygen species metabolic process (GO:2000378)2.62063298
173reflex (GO:0060004)2.61762064
174aromatic amino acid family metabolic process (GO:0009072)2.61288660
175water-soluble vitamin biosynthetic process (GO:0042364)2.61042670
176exogenous drug catabolic process (GO:0042738)2.60419493
177positive regulation of defense response to virus by host (GO:0002230)2.59280124
178response to misfolded protein (GO:0051788)2.59114704
179membrane depolarization during action potential (GO:0086010)2.58030797
180phosphatidylinositol acyl-chain remodeling (GO:0036149)2.57170784
181monoubiquitinated protein deubiquitination (GO:0035520)2.52671949
182protein polyglutamylation (GO:0018095)2.52539790
183double-strand break repair via homologous recombination (GO:0000724)2.52140120
184recombinational repair (GO:0000725)2.51826785
185embryonic axis specification (GO:0000578)2.51603140
186positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.51254299
187nephron epithelium morphogenesis (GO:0072088)2.50725892
188nephron tubule morphogenesis (GO:0072078)2.50725892
189kidney morphogenesis (GO:0060993)2.50452587
1903-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.50201507
191purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.50201507
192preassembly of GPI anchor in ER membrane (GO:0016254)2.46884329
193meiotic chromosome segregation (GO:0045132)2.46468018
194cilium or flagellum-dependent cell motility (GO:0001539)2.46281603
195negative regulation by host of viral transcription (GO:0043922)2.45473923
196regulation of establishment of cell polarity (GO:2000114)2.45032214
197benzene-containing compound metabolic process (GO:0042537)2.44467713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.96293214
2GABP_17652178_ChIP-ChIP_JURKAT_Human4.16330647
3ZNF274_21170338_ChIP-Seq_K562_Hela4.11175768
4EZH2_22144423_ChIP-Seq_EOC_Human4.02633273
5MYC_18555785_ChIP-Seq_MESCs_Mouse4.01932977
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.86391158
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.81773244
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.67117098
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.66975626
10E2F7_22180533_ChIP-Seq_HELA_Human3.56097385
11ETS1_20019798_ChIP-Seq_JURKAT_Human3.43815958
12ELF1_17652178_ChIP-ChIP_JURKAT_Human3.33667725
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.25992624
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.23399790
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.22683552
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.20482764
17VDR_22108803_ChIP-Seq_LS180_Human3.13762786
18SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.09219349
19MYC_18358816_ChIP-ChIP_MESCs_Mouse3.03252022
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98563381
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97681478
22GBX2_23144817_ChIP-Seq_PC3_Human2.80887982
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.79959388
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.61886185
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60510648
26VDR_23849224_ChIP-Seq_CD4+_Human2.60140725
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57424406
28SRF_21415370_ChIP-Seq_HL-1_Mouse2.49946571
29SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.40190874
30ELK1_19687146_ChIP-ChIP_HELA_Human2.36942044
31E2F1_18555785_ChIP-Seq_MESCs_Mouse2.34371233
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.32074504
33DCP1A_22483619_ChIP-Seq_HELA_Human2.29249795
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.25337849
35THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23149668
36FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.21716599
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.20444818
38XRN2_22483619_ChIP-Seq_HELA_Human2.13519074
39MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09734097
40NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09012143
41CTBP2_25329375_ChIP-Seq_LNCAP_Human2.06273729
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.99160296
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.98171777
44GABP_19822575_ChIP-Seq_HepG2_Human1.95415852
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.94127835
46ELK1_22589737_ChIP-Seq_MCF10A_Human1.93606017
47EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.93395943
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.92551868
49IRF1_19129219_ChIP-ChIP_H3396_Human1.88949274
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88466991
51ER_23166858_ChIP-Seq_MCF-7_Human1.88176562
52CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.84401326
53CTBP1_25329375_ChIP-Seq_LNCAP_Human1.83240829
54FOXP3_21729870_ChIP-Seq_TREG_Human1.82400740
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.80298618
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.72153891
57DROSHA_22980978_ChIP-Seq_HELA_Human1.70269600
58TTF2_22483619_ChIP-Seq_HELA_Human1.67803625
59TAF15_26573619_Chip-Seq_HEK293_Human1.67286542
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.63287953
61TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.60499545
62POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.60499545
63* REST_21632747_ChIP-Seq_MESCs_Mouse1.60154713
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.59147932
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56107505
66IGF1R_20145208_ChIP-Seq_DFB_Human1.54771196
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54418964
68STAT3_23295773_ChIP-Seq_U87_Human1.54362774
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54241762
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.52608999
71P300_19829295_ChIP-Seq_ESCs_Human1.52346092
72AR_21572438_ChIP-Seq_LNCaP_Human1.50579706
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49631347
74ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49116187
75YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47388219
76SALL1_21062744_ChIP-ChIP_HESCs_Human1.46158733
77TCF4_23295773_ChIP-Seq_U87_Human1.43343232
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.42837825
79ERA_21632823_ChIP-Seq_H3396_Human1.42044690
80TP53_22573176_ChIP-Seq_HFKS_Human1.40462095
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40416730
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.40291311
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.37484852
84HOXB7_26014856_ChIP-Seq_BT474_Human1.36794747
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34467654
86CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.34049118
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.33919403
88POU3F2_20337985_ChIP-ChIP_501MEL_Human1.33561704
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33102232
90BCAT_22108803_ChIP-Seq_LS180_Human1.32836377
91AR_21909140_ChIP-Seq_LNCAP_Human1.32571138
92AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31606641
93ETV2_25802403_ChIP-Seq_MESCs_Mouse1.30050822
94MYCN_18555785_ChIP-Seq_MESCs_Mouse1.30017453
95PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29620836
96PIAS1_25552417_ChIP-Seq_VCAP_Human1.29170794
97FOXA1_25329375_ChIP-Seq_VCAP_Human1.28960361
98FOXA1_27270436_Chip-Seq_PROSTATE_Human1.28960361
99PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28856902
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.27677298
101TDRD3_21172665_ChIP-Seq_MCF-7_Human1.23713896
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23494907
103AR_25329375_ChIP-Seq_VCAP_Human1.23265278
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22094275
105PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21478688
106OCT4_20526341_ChIP-Seq_ESCs_Human1.20788125
107EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20726475
108NCOR_22424771_ChIP-Seq_293T_Human1.19853276
109CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18589435
110PRDM14_20953172_ChIP-Seq_ESCs_Human1.18536018
111CBX2_27304074_Chip-Seq_ESCs_Mouse1.17330963
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16653184
113DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16554245
114JARID2_20075857_ChIP-Seq_MESCs_Mouse1.16267400
115EZH2_27294783_Chip-Seq_ESCs_Mouse1.15098088
116CBP_20019798_ChIP-Seq_JUKART_Human1.15068729
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15068729
118FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.13907569
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.13573293
120HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.13503964
121NANOG_19829295_ChIP-Seq_ESCs_Human1.12740404
122SOX2_19829295_ChIP-Seq_ESCs_Human1.12740404
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.12577134
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12461908
125NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.11602924
126SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11392594
127TP53_16413492_ChIP-PET_HCT116_Human1.11062138
128E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10894117
129SMAD4_21741376_ChIP-Seq_EPCs_Human1.10763248
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.10749128
131SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10617037
132RUNX2_22187159_ChIP-Seq_PCA_Human1.10304700
133TAF2_19829295_ChIP-Seq_ESCs_Human1.09875829
134EED_16625203_ChIP-ChIP_MESCs_Mouse1.09741023
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09480787
136P53_21459846_ChIP-Seq_SAOS-2_Human1.09002807
137JARID2_20064375_ChIP-Seq_MESCs_Mouse1.08356101
138FLI1_21867929_ChIP-Seq_TH2_Mouse1.08273218
139SOX17_20123909_ChIP-Seq_XEN_Mouse1.08124761
140EZH2_27304074_Chip-Seq_ESCs_Mouse1.07166899
141IRF8_22096565_ChIP-ChIP_GC-B_Human1.06243614
142SMAD4_21799915_ChIP-Seq_A2780_Human1.05620441
143SPI1_23547873_ChIP-Seq_NB4_Human1.05515934
144NOTCH1_21737748_ChIP-Seq_TLL_Human1.05254821
145TFEB_21752829_ChIP-Seq_HELA_Human1.04898233
146AHR_22903824_ChIP-Seq_MCF-7_Human1.03539403
147PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03275359
148GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03202518
149AR_20517297_ChIP-Seq_VCAP_Human1.02751532
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.02657553
151CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02651722
152OCT1_27270436_Chip-Seq_PROSTATE_Human1.02646661
153ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02607182
154POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01910620
155TRIM28_21343339_ChIP-Seq_HEK293_Human1.01858701
156TCF4_22108803_ChIP-Seq_LS180_Human1.01799492
157ARNT_22903824_ChIP-Seq_MCF-7_Human1.01514735
158FOXH1_21741376_ChIP-Seq_ESCs_Human1.00839252
159FOXA1_21572438_ChIP-Seq_LNCaP_Human1.00435711
160YY1_21170310_ChIP-Seq_MESCs_Mouse0.99573100
161RAC3_21632823_ChIP-Seq_H3396_Human0.99446063
162EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.99157125
163MYC_19829295_ChIP-Seq_ESCs_Human0.99014324
164SUZ12_27294783_Chip-Seq_ESCs_Mouse0.98682904
165NANOG_20526341_ChIP-Seq_ESCs_Human0.98261886
166RNF2_27304074_Chip-Seq_NSC_Mouse0.98142443
167SMAD3_21741376_ChIP-Seq_ESCs_Human0.97420613
168MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97404963
169POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.97097910
170MYC_18940864_ChIP-ChIP_HL60_Human0.96421159
171NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94860158
172ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93248205
173PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92377700
174ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88327881
175FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87129694
176LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.87055421
177ESR1_15608294_ChIP-ChIP_MCF-7_Human0.85685660
178ELF5_23300383_ChIP-Seq_T47D_Human0.83326097
179E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.82446769
180KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82411359
181FUS_26573619_Chip-Seq_HEK293_Human0.81895152
182CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.80327510
183SRY_22984422_ChIP-ChIP_TESTIS_Rat0.79076118
184E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79054891
185MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.78297280
186FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.78222312
187NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.77899085
188CTCF_18555785_ChIP-Seq_MESCs_Mouse0.77792657
189CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.75880526
190MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.75038442
191EWS_26573619_Chip-Seq_HEK293_Human0.73875360
192TBX5_21415370_ChIP-Seq_HL-1_Mouse0.73816452
193SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.73564703

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.06761052
2MP0005503_abnormal_tendon_morphology4.27046880
3MP0003279_aneurysm3.81239532
4MP0005171_absent_coat_pigmentation3.70982738
5MP0003646_muscle_fatigue3.47449152
6MP0009384_cardiac_valve_regurgitation3.33628977
7MP0000569_abnormal_digit_pigmentation3.12810152
8MP0003724_increased_susceptibility_to3.05947282
9MP0005275_abnormal_skin_tensile2.87679508
10MP0010386_abnormal_urinary_bladder2.80165424
11MP0003806_abnormal_nucleotide_metabolis2.78896404
12MP0002638_abnormal_pupillary_reflex2.78738996
13MP0004043_abnormal_pH_regulation2.71085237
14MP0003136_yellow_coat_color2.70785328
15MP0008877_abnormal_DNA_methylation2.62216515
16MP0006054_spinal_hemorrhage2.61225751
17MP0001542_abnormal_bone_strength2.58411569
18MP0000372_irregular_coat_pigmentation2.56799349
19MP0009697_abnormal_copulation2.47831689
20MP0006292_abnormal_olfactory_placode2.41151378
21MP0001968_abnormal_touch/_nociception2.40500329
22MP0005551_abnormal_eye_electrophysiolog2.24920852
23MP0003186_abnormal_redox_activity2.24097558
24MP0002938_white_spotting2.18924106
25MP0001958_emphysema2.15688415
26MP0003890_abnormal_embryonic-extraembry2.06169295
27MP0003787_abnormal_imprinting2.05723420
28MP0008872_abnormal_physiological_respon2.00614818
29MP0001986_abnormal_taste_sensitivity1.96598955
30MP0009046_muscle_twitch1.94434752
31MP0004130_abnormal_muscle_cell1.91490822
32MP0008875_abnormal_xenobiotic_pharmacok1.89972535
33MP0002653_abnormal_ependyma_morphology1.87071606
34MP0009745_abnormal_behavioral_response1.85057926
35MP0002138_abnormal_hepatobiliary_system1.82147975
36MP0009379_abnormal_foot_pigmentation1.81616376
37MP0000427_abnormal_hair_cycle1.78771050
38MP0000465_gastrointestinal_hemorrhage1.74489854
39MP0002876_abnormal_thyroid_physiology1.71794149
40MP0001485_abnormal_pinna_reflex1.70570734
41MP0008961_abnormal_basal_metabolism1.70079174
42MP0005646_abnormal_pituitary_gland1.64290072
43MP0002735_abnormal_chemical_nociception1.62639744
44MP0002736_abnormal_nociception_after1.62493018
45MP0002396_abnormal_hematopoietic_system1.58166417
46MP0002102_abnormal_ear_morphology1.54440294
47MP0002272_abnormal_nervous_system1.53137513
48MP0005508_abnormal_skeleton_morphology1.52808510
49MP0000013_abnormal_adipose_tissue1.51472465
50MP0005408_hypopigmentation1.50850676
51MP0000749_muscle_degeneration1.48830086
52MP0005085_abnormal_gallbladder_physiolo1.47154237
53MP0008007_abnormal_cellular_replicative1.46727155
54MP0002160_abnormal_reproductive_system1.45530155
55MP0001501_abnormal_sleep_pattern1.43970723
56MP0006036_abnormal_mitochondrial_physio1.38084697
57MP0006082_CNS_inflammation1.33939905
58MP0004885_abnormal_endolymph1.31909534
59MP0002733_abnormal_thermal_nociception1.31520685
60MP0003252_abnormal_bile_duct1.31096964
61MP0004957_abnormal_blastocyst_morpholog1.29818910
62MP0002933_joint_inflammation1.29645446
63MP0002064_seizures1.29214768
64MP0001905_abnormal_dopamine_level1.28914260
65MP0004272_abnormal_basement_membrane1.28582972
66MP0008932_abnormal_embryonic_tissue1.26484402
67MP0003879_abnormal_hair_cell1.25394472
68MP0010094_abnormal_chromosome_stability1.25328083
69MP0003119_abnormal_digestive_system1.24216021
70MP0005377_hearing/vestibular/ear_phenot1.23878473
71MP0003878_abnormal_ear_physiology1.23878473
72MP0002572_abnormal_emotion/affect_behav1.23115105
73MP0003283_abnormal_digestive_organ1.21942659
74MP0005389_reproductive_system_phenotype1.21814832
75MP0001486_abnormal_startle_reflex1.21167496
76MP0002928_abnormal_bile_duct1.20032840
77MP0005423_abnormal_somatic_nervous1.19670403
78MP0005386_behavior/neurological_phenoty1.19263753
79MP0004924_abnormal_behavior1.19263753
80MP0005390_skeleton_phenotype1.17960881
81MP0010329_abnormal_lipoprotein_level1.17262463
82MP0003718_maternal_effect1.16982212
83MP0001970_abnormal_pain_threshold1.16701672
84MP0000631_abnormal_neuroendocrine_gland1.16469809
85MP0002557_abnormal_social/conspecific_i1.16319355
86MP0005448_abnormal_energy_balance1.16265190
87MP0010030_abnormal_orbit_morphology1.16102985
88MP0000383_abnormal_hair_follicle1.15092502
89MP0005645_abnormal_hypothalamus_physiol1.14744683
90MP0002282_abnormal_trachea_morphology1.11378595
91MP0004742_abnormal_vestibular_system1.11227019
92MP0000750_abnormal_muscle_regeneration1.10238656
93MP0001243_abnormal_dermal_layer1.10146556
94MP0002060_abnormal_skin_morphology1.09720396
95MP0002234_abnormal_pharynx_morphology1.07847171
96MP0005023_abnormal_wound_healing1.07817985
97MP0002067_abnormal_sensory_capabilities1.04603652
98MP0006072_abnormal_retinal_apoptosis1.04304011
99MP0001873_stomach_inflammation1.03782352
100MP0005253_abnormal_eye_physiology1.02576301
101MP0003693_abnormal_embryo_hatching1.02054783
102MP0001533_abnormal_skeleton_physiology1.01686108
103MP0000343_altered_response_to1.00614862
104MP0005365_abnormal_bile_salt0.99545140
105MP0005220_abnormal_exocrine_pancreas0.99430381
106MP0000470_abnormal_stomach_morphology0.98892041
107MP0002063_abnormal_learning/memory/cond0.98010239
108MP0002295_abnormal_pulmonary_circulatio0.97829635
109MP0006276_abnormal_autonomic_nervous0.97362741
110MP0003137_abnormal_impulse_conducting0.96858902
111MP0003077_abnormal_cell_cycle0.96154898
112MP0006035_abnormal_mitochondrial_morpho0.95793589
113MP0009250_abnormal_appendicular_skeleto0.95769213
114MP0003705_abnormal_hypodermis_morpholog0.95098183
115MP0005164_abnormal_response_to0.94567985
116MP0005670_abnormal_white_adipose0.94376693
117MP0005595_abnormal_vascular_smooth0.93998524
118MP0002089_abnormal_postnatal_growth/wei0.93453491
119MP0004147_increased_porphyrin_level0.91125510
120MP0003635_abnormal_synaptic_transmissio0.90781089
121MP0003111_abnormal_nucleus_morphology0.90723611
122MP0005266_abnormal_metabolism0.90583724
123MP0001188_hyperpigmentation0.89241044
124MP0004381_abnormal_hair_follicle0.89082378
125MP0001324_abnormal_eye_pigmentation0.88432667
126MP0005410_abnormal_fertilization0.88336057
127MP0005195_abnormal_posterior_eye0.87383372
128MP0005197_abnormal_uvea_morphology0.87206480
129MP0003786_premature_aging0.86682309
130MP0003698_abnormal_male_reproductive0.86638172
131MP0001764_abnormal_homeostasis0.85981368
132MP0001919_abnormal_reproductive_system0.85046890
133MP0003195_calcinosis0.83885904
134MP0005084_abnormal_gallbladder_morpholo0.83540347
135MP0001664_abnormal_digestion0.81631119
136MP0004134_abnormal_chest_morphology0.81252832
137MP0009840_abnormal_foam_cell0.80765658
138MP0001502_abnormal_circadian_rhythm0.80682552
139MP0001756_abnormal_urination0.80506481
140MP0005167_abnormal_blood-brain_barrier0.79808638
141MP0004142_abnormal_muscle_tone0.78762183
142MP0001440_abnormal_grooming_behavior0.78370671
143MP0005083_abnormal_biliary_tract0.77761383
144MP0000026_abnormal_inner_ear0.77251628
145MP0002177_abnormal_outer_ear0.76860398
146MP0001963_abnormal_hearing_physiology0.75423405
147MP0005332_abnormal_amino_acid0.74774723
148MP0005165_increased_susceptibility_to0.73791835
149MP0003123_paternal_imprinting0.73763750
150MP0005174_abnormal_tail_pigmentation0.73559803
151MP0005376_homeostasis/metabolism_phenot0.73526776
152MP0005075_abnormal_melanosome_morpholog0.73482167
153MP0000538_abnormal_urinary_bladder0.73349153
154MP0003937_abnormal_limbs/digits/tail_de0.72543657
155MP0008995_early_reproductive_senescence0.70623127
156MP0002877_abnormal_melanocyte_morpholog0.69959926
157MP0002132_abnormal_respiratory_system0.69532557
158MP0002837_dystrophic_cardiac_calcinosis0.69286457
159MP0005379_endocrine/exocrine_gland_phen0.69072262
160MP0000313_abnormal_cell_death0.69051087
161MP0004145_abnormal_muscle_electrophysio0.68595993
162MP0003866_abnormal_defecation0.67017506
163MP0005671_abnormal_response_to0.66656282
164MP0008873_increased_physiological_sensi0.65078564
165MP0005000_abnormal_immune_tolerance0.64478436
166MP0002095_abnormal_skin_pigmentation0.64303885
167MP0000358_abnormal_cell_content/0.63033647
168MP0001853_heart_inflammation0.61287819
169MP0000858_altered_metastatic_potential0.61229788
170MP0003959_abnormal_lean_body0.60241760
171MP0001270_distended_abdomen0.58834024
172MP0002115_abnormal_skeleton_extremities0.58413776
173MP0008469_abnormal_protein_level0.58197160
174MP0005367_renal/urinary_system_phenotyp0.57549942
175MP0000516_abnormal_urinary_system0.57549942
176MP0004133_heterotaxia0.56715192
177MP0008058_abnormal_DNA_repair0.55657753
178MP0002113_abnormal_skeleton_development0.54991111
179MP0010352_gastrointestinal_tract_polyps0.54650331
180MP0004808_abnormal_hematopoietic_stem0.54309788
181MP0002139_abnormal_hepatobiliary_system0.54258021
182MP0000230_abnormal_systemic_arterial0.53931046
183MP0005395_other_phenotype0.53357568

Predicted human phenotypes

RankGene SetZ-score
1Spinal cord lesions (HP:0100561)4.66730843
2Syringomyelia (HP:0003396)4.66730843
3Protrusio acetabuli (HP:0003179)4.63684707
4Genetic anticipation (HP:0003743)4.63069753
5Pancreatic cysts (HP:0001737)4.56276732
6Premature rupture of membranes (HP:0001788)4.38916434
7Congenital stationary night blindness (HP:0007642)4.18628420
8Abnormality of midbrain morphology (HP:0002418)4.18207591
9Molar tooth sign on MRI (HP:0002419)4.18207591
10Birth length less than 3rd percentile (HP:0003561)4.05777452
11Vertebral compression fractures (HP:0002953)4.04682405
12Hepatocellular necrosis (HP:0001404)3.97449915
13Abnormal mitochondria in muscle tissue (HP:0008316)3.94638421
14Acute necrotizing encephalopathy (HP:0006965)3.88623997
15Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.85104475
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.85104475
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.81518573
18Abnormality of alanine metabolism (HP:0010916)3.81518573
19Hyperalaninemia (HP:0003348)3.81518573
20Soft skin (HP:0000977)3.72522179
21Clumsiness (HP:0002312)3.67860652
22Rough bone trabeculation (HP:0100670)3.66985886
23Protruding tongue (HP:0010808)3.61778873
24Pancreatic fibrosis (HP:0100732)3.61456168
25Hepatic necrosis (HP:0002605)3.60886150
26Mitochondrial inheritance (HP:0001427)3.53268873
27Progressive cerebellar ataxia (HP:0002073)3.45758872
28Hyperventilation (HP:0002883)3.42399022
29Attenuation of retinal blood vessels (HP:0007843)3.40452170
30True hermaphroditism (HP:0010459)3.35193585
31Increased CSF lactate (HP:0002490)3.26015019
32Abnormality of cells of the erythroid lineage (HP:0012130)3.25346832
33Nephronophthisis (HP:0000090)3.24794990
34Progressive macrocephaly (HP:0004481)3.21150857
35Patellar aplasia (HP:0006443)3.20375744
36Gaze-evoked nystagmus (HP:0000640)3.16106615
37Biconcave vertebral bodies (HP:0004586)3.14533170
38Premature graying of hair (HP:0002216)3.12263321
39Abnormal number of erythroid precursors (HP:0012131)3.12137246
40Aplasia/Hypoplasia of the patella (HP:0006498)3.07663417
41Abnormality of the renal cortex (HP:0011035)3.05490640
42Decreased circulating renin level (HP:0003351)3.02330261
43Pendular nystagmus (HP:0012043)2.96569857
44Reticulocytopenia (HP:0001896)2.94889740
45Acute encephalopathy (HP:0006846)2.93669215
46Abnormality of the renal medulla (HP:0100957)2.89967797
47Abolished electroretinogram (ERG) (HP:0000550)2.85137059
48Inability to walk (HP:0002540)2.84370440
49Cystic liver disease (HP:0006706)2.84279864
50Aortic dissection (HP:0002647)2.82621578
51Progressive inability to walk (HP:0002505)2.80239781
52Hypothermia (HP:0002045)2.74914423
53Increased neuronal autofluorescent lipopigment (HP:0002074)2.73459273
54Tubular atrophy (HP:0000092)2.71277096
55Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.70561782
56Microvesicular hepatic steatosis (HP:0001414)2.63261974
57Abnormality of dentin (HP:0010299)2.60118501
58Thrombocytosis (HP:0001894)2.59611903
59Aortic aneurysm (HP:0004942)2.57015449
60Abnormal trabecular bone morphology (HP:0100671)2.55294798
61Decreased central vision (HP:0007663)2.48853364
62Chronic hepatic failure (HP:0100626)2.48563645
63Entropion (HP:0000621)2.47210071
64Large for gestational age (HP:0001520)2.46889064
65Respiratory failure (HP:0002878)2.46563082
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.46554624
67Increased serum pyruvate (HP:0003542)2.45198866
68Abnormality of glycolysis (HP:0004366)2.45198866
69Concave nail (HP:0001598)2.44169575
70Follicular hyperkeratosis (HP:0007502)2.43339781
71Increased intramyocellular lipid droplets (HP:0012240)2.42478694
72Broad-based gait (HP:0002136)2.40088037
73Joint stiffness (HP:0001387)2.39037249
74Increased hepatocellular lipid droplets (HP:0006565)2.38759120
75Opisthotonus (HP:0002179)2.37435506
76Fair hair (HP:0002286)2.36457845
77Poor head control (HP:0002421)2.35484609
78Aplastic anemia (HP:0001915)2.35431162
79Progressive neurologic deterioration (HP:0002344)2.35071563
80Renal Fanconi syndrome (HP:0001994)2.34573740
81Abnormality of aromatic amino acid family metabolism (HP:0004338)2.34321727
82Macrocytic anemia (HP:0001972)2.33704069
83Breast hypoplasia (HP:0003187)2.33613309
84Type I transferrin isoform profile (HP:0003642)2.33500330
85Decreased electroretinogram (ERG) amplitude (HP:0000654)2.30713847
86Autoamputation (HP:0001218)2.27000998
87Abnormality of the renal collecting system (HP:0004742)2.26379295
88Cerebellar dysplasia (HP:0007033)2.25815287
89Abnormal drinking behavior (HP:0030082)2.24708748
90Polydipsia (HP:0001959)2.24708748
91Increased serum lactate (HP:0002151)2.24108771
92Chorioretinal atrophy (HP:0000533)2.22768945
93Exercise intolerance (HP:0003546)2.21296643
94Wormian bones (HP:0002645)2.21294445
95Keratoconus (HP:0000563)2.21187734
96Increased corneal curvature (HP:0100692)2.21187734
97Severe muscular hypotonia (HP:0006829)2.20276328
98Pallor (HP:0000980)2.16947784
99Abnormal rod and cone electroretinograms (HP:0008323)2.16813071
100Lipid accumulation in hepatocytes (HP:0006561)2.16729366
101Short middle phalanx of the 5th finger (HP:0004220)2.16372050
102Abnormal delivery (HP:0001787)2.16301410
103Abnormalities of placenta or umbilical cord (HP:0001194)2.16261282
104Bony spicule pigmentary retinopathy (HP:0007737)2.16184303
105Purpura (HP:0000979)2.15517922
106Medial flaring of the eyebrow (HP:0010747)2.15158470
107Lissencephaly (HP:0001339)2.13574843
108Stomach cancer (HP:0012126)2.12111656
109Cerebral edema (HP:0002181)2.12017933
110Duplicated collecting system (HP:0000081)2.11491518
111Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07025730
112Furrowed tongue (HP:0000221)2.06187302
113Patchy hypopigmentation of hair (HP:0011365)2.04885660
114Congenital sensorineural hearing impairment (HP:0008527)2.04483447
115Increased cerebral lipofuscin (HP:0011813)2.03698283
116Congenital hepatic fibrosis (HP:0002612)2.03132845
117Absent/shortened dynein arms (HP:0200106)2.02945685
118Dynein arm defect of respiratory motile cilia (HP:0012255)2.02945685
119Abnormal pupillary function (HP:0007686)2.01622692
120Neoplasm of head and neck (HP:0012288)2.01095173
121Esophageal neoplasm (HP:0100751)2.01095173
122Flat capital femoral epiphysis (HP:0003370)2.00577926
123Hypoplasia of the pons (HP:0012110)1.98971113
124Increased muscle lipid content (HP:0009058)1.98474933
125Small hand (HP:0200055)1.98048478
126Amniotic constriction ring (HP:0009775)1.96621131
127Abnormality of placental membranes (HP:0011409)1.96621131
128Bulbous nose (HP:0000414)1.96343757
129Abnormality of the umbilical cord (HP:0010881)1.95702932
130Febrile seizures (HP:0002373)1.94627160
131Lactic acidosis (HP:0003128)1.93697018
132Sclerocornea (HP:0000647)1.93493533
133White forelock (HP:0002211)1.93456610
134Congenital, generalized hypertrichosis (HP:0004540)1.93359796
135Anencephaly (HP:0002323)1.93354185
136Amelogenesis imperfecta (HP:0000705)1.92922571
137Abnormality of the heme biosynthetic pathway (HP:0010472)1.90919373
138Epiphyseal stippling (HP:0010655)1.88991847
139Prolonged neonatal jaundice (HP:0006579)1.88916820
140Generalized hypopigmentation of hair (HP:0011358)1.87349486
141Cervical subluxation (HP:0003308)1.86734428
142CNS demyelination (HP:0007305)1.83593815
143Bilateral microphthalmos (HP:0007633)1.82715293
144Leukodystrophy (HP:0002415)1.82609352
145Melanoma (HP:0002861)1.81207662
146Ankle contracture (HP:0006466)1.80691951
147Vertebral hypoplasia (HP:0008417)1.80132400
148Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.80132400
149Tachypnea (HP:0002789)1.79919174
150Vascular tortuosity (HP:0004948)1.78983394
151Blue sclerae (HP:0000592)1.78122947
152Aplasia/Hypoplasia of the tongue (HP:0010295)1.78024599
153Type II lissencephaly (HP:0007260)1.77628481
154Hypokinesia (HP:0002375)1.77220386
155Slender build (HP:0001533)1.77198926
156Polyuria (HP:0000103)1.76905956
157Microretrognathia (HP:0000308)1.76257229
158Impaired smooth pursuit (HP:0007772)1.74275422
159Abnormality of the pons (HP:0007361)1.74241584
160Neoplasm of the pancreas (HP:0002894)1.73679434
161Renal cortical cysts (HP:0000803)1.73117657
162Optic disc pallor (HP:0000543)1.71960325
163Gait imbalance (HP:0002141)1.71947473
164Adrenal hypoplasia (HP:0000835)1.70499045
165Hypoplastic left heart (HP:0004383)1.70332579
166Hypoplastic ischia (HP:0003175)1.69856962
167Hyperglycinuria (HP:0003108)1.69514859
168Male pseudohermaphroditism (HP:0000037)1.69299267
169Aplasia/Hypoplasia involving the musculature (HP:0001460)1.69254092
170Hypoplastic heart (HP:0001961)1.67185052
171Dialeptic seizures (HP:0011146)1.66828578
172Muscle fiber atrophy (HP:0100295)1.66450812
173Petechiae (HP:0000967)1.65776255
174Aplasia/Hypoplasia of the sacrum (HP:0008517)1.64850283
175Macroglossia (HP:0000158)1.63725554
176Type 2 muscle fiber atrophy (HP:0003554)1.63610962
177Partial agenesis of the corpus callosum (HP:0001338)1.62764307
178Abnormality of renin-angiotensin system (HP:0000847)1.62169306
179Dyskinesia (HP:0100660)1.61926368
180Ketosis (HP:0001946)1.61705487
181Increased number of teeth (HP:0011069)1.61705319
182Absent thumb (HP:0009777)1.61436721
183Aplasia/Hypoplasia of the uvula (HP:0010293)1.60444074
184Abnormal biliary tract physiology (HP:0012439)1.60256111
185Bile duct proliferation (HP:0001408)1.60256111
186Nonimmune hydrops fetalis (HP:0001790)1.59625926
187Abnormality of binocular vision (HP:0011514)1.59616649
188Diplopia (HP:0000651)1.59616649
189Congenital primary aphakia (HP:0007707)1.59409528
190Osteolytic defects of the hand bones (HP:0009699)1.59407142
191Nephrogenic diabetes insipidus (HP:0009806)1.59221321
192Abnormality of the nasal septum (HP:0000419)1.58302162

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.31122814
2ACVR1B4.46244468
3STK164.43748859
4BMPR1B4.02964701
5PIM23.59699938
6FLT33.47299415
7NME23.13356802
8BUB12.89520959
9WNK42.73451356
10GRK12.42828491
11MKNK12.40759059
12TAOK32.37666087
13AKT32.32743190
14MUSK2.28821382
15ARAF2.26308615
16KIT2.12834928
17EIF2AK32.12471216
18WEE12.09701545
19ERN12.05214136
20EIF2AK11.93221902
21PBK1.92461545
22TESK21.88478793
23DAPK21.82008910
24ERBB31.77485967
25BRSK21.72817489
26VRK11.72069230
27NUAK11.71324462
28MAPKAPK51.69994262
29NEK91.57005920
30MYLK1.56577304
31PIK3CG1.54468311
32MAPK131.49636685
33PINK11.48051952
34ADRBK11.46080748
35MKNK21.43254136
36MAP4K21.37307381
37ZAK1.36269854
38OXSR11.31424859
39MAPK151.30568907
40WNK31.29805695
41TXK1.21740282
42SIK21.20918503
43NME11.19627187
44CDK81.18484908
45DYRK31.17078361
46SRPK11.16857214
47TSSK61.16855256
48NTRK31.16552532
49BCKDK1.16349731
50CSF1R1.15973374
51MAPKAPK31.15581348
52JAK31.15155830
53TEC1.14180594
54PIK3CA1.09667175
55TGFBR21.07938605
56LRRK21.07347322
57LATS21.06212588
58MAP3K121.04667677
59CASK1.02906079
60MOS1.02409972
61SIK11.00738011
62RPS6KA40.97700177
63ZAP700.95635013
64MAP2K70.95387794
65NEK20.94628652
66TNK20.91713855
67INSRR0.91712760
68MELK0.91231163
69NLK0.91028693
70PAK20.88392649
71CDC70.85464324
72PASK0.85356484
73PLK30.84739330
74MAP2K60.84275708
75PTK2B0.83187452
76CCNB10.81900088
77WNK10.80623077
78CDK190.79715897
79TNIK0.79605815
80ADRBK20.77808353
81CAMK1D0.76600301
82RPS6KA60.76282704
83CHUK0.75727710
84PRKCG0.73176789
85TGFBR10.73116503
86MET0.71539973
87DDR20.71272179
88LIMK10.70309758
89STK380.70127121
90MAP3K40.69369428
91STK110.67943113
92ERBB20.66981216
93STK390.65852840
94PLK20.64289301
95BRAF0.63504654
96EIF2AK20.61258632
97PRKAA20.60734599
98SIK30.59896072
99PRKD20.59396049
100LCK0.59115431
101RPS6KA50.58588195
102ABL20.58568046
103PLK10.58494385
104TRPM70.57895808
105PKN10.55684319
106CAMK10.55660153
107MAP2K20.55513797
108MST40.54682480
109RAF10.53933981
110DYRK20.52404441
111CAMKK20.52161091
112LATS10.52010546
113MAP3K70.51849687
114STK38L0.50683702
115SGK20.50370893
116LYN0.49811884
117RPS6KB20.49497363
118STK30.49415501
119NEK10.49116888
120AURKB0.48583566
121TYRO30.48404864
122KDR0.48184217
123CSNK2A10.46982643
124CHEK20.46396106
125PRKCE0.46316098
126EPHA30.46120439
127MARK30.46090142
128PRKAA10.46071713
129TLK10.45908579
130PRKCQ0.44668839
131IRAK10.44072938
132PHKG20.43641400
133PHKG10.43641400
134SCYL20.43248828
135SYK0.42777134
136BRSK10.42667569
137MAP2K10.42242669
138IKBKB0.41996032
139ITK0.41896846
140PAK30.41655187
141CLK10.41468479
142IGF1R0.40254756
143MAP3K140.40082930
144CDK140.39943244
145PLK40.39800098
146ATR0.39483034
147TIE10.39205396
148IRAK40.39108179
149BTK0.38633742
150PRKG20.38322598
151MAP4K10.38260597
152MAPK110.38139056
153PRKCI0.37028801
154CAMK2A0.36551236
155DAPK10.36172576
156SGK4940.35976830
157SGK2230.35976830
158PAK40.35601076
159PRKACA0.35392988
160CSNK1D0.35250818
161DAPK30.35119198
162MAPK40.34646674
163MAP3K110.34069922
164CAMK40.33870291
165IRAK20.33291653
166PAK10.32786123
167PRKCH0.32583170
168CAMKK10.32300652
169CAMK1G0.32218358
170SGK10.29073585
171PIM10.27849822
172MAPK80.27799572
173BLK0.27437166

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.35225799
2Proteasome_Homo sapiens_hsa030504.30135322
3Protein export_Homo sapiens_hsa030603.99497732
4RNA polymerase_Homo sapiens_hsa030203.35765935
5Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.07877447
6Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.79045889
7Nitrogen metabolism_Homo sapiens_hsa009102.73308564
8DNA replication_Homo sapiens_hsa030302.73058544
9Phototransduction_Homo sapiens_hsa047442.72905481
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62844831
11Oxidative phosphorylation_Homo sapiens_hsa001902.55955177
12Parkinsons disease_Homo sapiens_hsa050122.45921194
13Pyrimidine metabolism_Homo sapiens_hsa002402.39544190
14Nicotine addiction_Homo sapiens_hsa050332.29438922
15Mismatch repair_Homo sapiens_hsa034302.16466224
16Spliceosome_Homo sapiens_hsa030402.07602757
17Tryptophan metabolism_Homo sapiens_hsa003802.06710368
18Taste transduction_Homo sapiens_hsa047422.01043750
19Nucleotide excision repair_Homo sapiens_hsa034201.95801569
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.90390360
21Folate biosynthesis_Homo sapiens_hsa007901.89581224
22Steroid biosynthesis_Homo sapiens_hsa001001.79461624
23Butanoate metabolism_Homo sapiens_hsa006501.78106817
24ABC transporters_Homo sapiens_hsa020101.76131622
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76120028
26Caffeine metabolism_Homo sapiens_hsa002321.73204254
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.71182873
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.65236559
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64172895
30Fatty acid elongation_Homo sapiens_hsa000621.59567701
31Histidine metabolism_Homo sapiens_hsa003401.57069947
32Morphine addiction_Homo sapiens_hsa050321.54171003
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.47738823
34Alzheimers disease_Homo sapiens_hsa050101.47122130
35Other glycan degradation_Homo sapiens_hsa005111.46375853
36Huntingtons disease_Homo sapiens_hsa050161.44470695
37Non-homologous end-joining_Homo sapiens_hsa034501.42459647
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41336978
39Base excision repair_Homo sapiens_hsa034101.40628531
40RNA degradation_Homo sapiens_hsa030181.38869281
41RNA transport_Homo sapiens_hsa030131.37510121
42Olfactory transduction_Homo sapiens_hsa047401.34496691
43Fanconi anemia pathway_Homo sapiens_hsa034601.33014084
44Purine metabolism_Homo sapiens_hsa002301.31981259
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.30919474
46Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.29493948
47Glycerolipid metabolism_Homo sapiens_hsa005611.27924496
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.27599113
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23318466
50Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23222989
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.19154083
52SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18209370
53Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18078639
54Chemical carcinogenesis_Homo sapiens_hsa052041.17196945
55Serotonergic synapse_Homo sapiens_hsa047261.16622219
56Glutamatergic synapse_Homo sapiens_hsa047241.15472116
57Homologous recombination_Homo sapiens_hsa034401.13436579
58Ovarian steroidogenesis_Homo sapiens_hsa049131.12467142
59Primary bile acid biosynthesis_Homo sapiens_hsa001201.11655409
60Calcium signaling pathway_Homo sapiens_hsa040201.08279237
61Cyanoamino acid metabolism_Homo sapiens_hsa004601.06329800
62Circadian entrainment_Homo sapiens_hsa047131.05705984
63Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.03819071
64Insulin secretion_Homo sapiens_hsa049111.03369644
65N-Glycan biosynthesis_Homo sapiens_hsa005101.02832635
66Dorso-ventral axis formation_Homo sapiens_hsa043201.02233524
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98109063
68Cell cycle_Homo sapiens_hsa041100.97276452
69Fat digestion and absorption_Homo sapiens_hsa049750.96590544
70GABAergic synapse_Homo sapiens_hsa047270.96314508
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95518926
72Malaria_Homo sapiens_hsa051440.94925446
73Vibrio cholerae infection_Homo sapiens_hsa051100.94896540
74One carbon pool by folate_Homo sapiens_hsa006700.94544220
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.93691329
76Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93085523
77Peroxisome_Homo sapiens_hsa041460.90753957
78Arachidonic acid metabolism_Homo sapiens_hsa005900.88280113
79Vitamin B6 metabolism_Homo sapiens_hsa007500.86658737
80Drug metabolism - other enzymes_Homo sapiens_hsa009830.84991889
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84256573
82Arginine and proline metabolism_Homo sapiens_hsa003300.83585973
83Vascular smooth muscle contraction_Homo sapiens_hsa042700.83578347
84p53 signaling pathway_Homo sapiens_hsa041150.81047289
85Pyruvate metabolism_Homo sapiens_hsa006200.80067467
86Lysine degradation_Homo sapiens_hsa003100.79229235
87Metabolic pathways_Homo sapiens_hsa011000.78167504
88Legionellosis_Homo sapiens_hsa051340.78021329
89Phagosome_Homo sapiens_hsa041450.77777039
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.76786947
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76496893
92beta-Alanine metabolism_Homo sapiens_hsa004100.74476570
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.73652576
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73335472
95Asthma_Homo sapiens_hsa053100.73255055
96Galactose metabolism_Homo sapiens_hsa000520.70858332
97Renin-angiotensin system_Homo sapiens_hsa046140.70119088
98Biosynthesis of amino acids_Homo sapiens_hsa012300.69866134
99Hematopoietic cell lineage_Homo sapiens_hsa046400.69004782
100Glutathione metabolism_Homo sapiens_hsa004800.68303122
101Fatty acid biosynthesis_Homo sapiens_hsa000610.68227183
102Basal transcription factors_Homo sapiens_hsa030220.66764219
103Long-term depression_Homo sapiens_hsa047300.66721208
104Cholinergic synapse_Homo sapiens_hsa047250.65166819
105Linoleic acid metabolism_Homo sapiens_hsa005910.64647325
106Sulfur relay system_Homo sapiens_hsa041220.64057559
107Rheumatoid arthritis_Homo sapiens_hsa053230.63788044
108Ether lipid metabolism_Homo sapiens_hsa005650.63160370
109Propanoate metabolism_Homo sapiens_hsa006400.60691698
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60125730
111Pentose phosphate pathway_Homo sapiens_hsa000300.59553382
112Graft-versus-host disease_Homo sapiens_hsa053320.59135488
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59098773
114Glycerophospholipid metabolism_Homo sapiens_hsa005640.59004350
115Salivary secretion_Homo sapiens_hsa049700.56454356
116Tyrosine metabolism_Homo sapiens_hsa003500.55961372
117Gastric acid secretion_Homo sapiens_hsa049710.55922315
118Epstein-Barr virus infection_Homo sapiens_hsa051690.53252625
119Primary immunodeficiency_Homo sapiens_hsa053400.51621018
120Pancreatic secretion_Homo sapiens_hsa049720.51097761
121Vitamin digestion and absorption_Homo sapiens_hsa049770.50702690
122Bile secretion_Homo sapiens_hsa049760.50520668
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48576371
124Fatty acid degradation_Homo sapiens_hsa000710.47890753
125Oxytocin signaling pathway_Homo sapiens_hsa049210.46523554
126Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46507680
127ECM-receptor interaction_Homo sapiens_hsa045120.44721587
128Lysosome_Homo sapiens_hsa041420.44351473
129Regulation of autophagy_Homo sapiens_hsa041400.44255614
130Type II diabetes mellitus_Homo sapiens_hsa049300.43950839
131cAMP signaling pathway_Homo sapiens_hsa040240.42706255
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.42467371
133Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42220123
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40265901
135Antigen processing and presentation_Homo sapiens_hsa046120.40174868
136Carbon metabolism_Homo sapiens_hsa012000.39902742
137Collecting duct acid secretion_Homo sapiens_hsa049660.38793062
138Selenocompound metabolism_Homo sapiens_hsa004500.38587140
139Maturity onset diabetes of the young_Homo sapiens_hsa049500.36767585
140Dopaminergic synapse_Homo sapiens_hsa047280.36596983
141Shigellosis_Homo sapiens_hsa051310.36409723
142Mineral absorption_Homo sapiens_hsa049780.33331219
143Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33255766
144Cocaine addiction_Homo sapiens_hsa050300.32794183
145Cardiac muscle contraction_Homo sapiens_hsa042600.32230960
146Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.30675147
147MAPK signaling pathway_Homo sapiens_hsa040100.30484789
148Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29023973
149NOD-like receptor signaling pathway_Homo sapiens_hsa046210.27860018
150Thyroid cancer_Homo sapiens_hsa052160.26512928
151Autoimmune thyroid disease_Homo sapiens_hsa053200.26501292
152Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.26161697
153Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25722917
154Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.25322400
155Type I diabetes mellitus_Homo sapiens_hsa049400.24735393
156Pentose and glucuronate interconversions_Homo sapiens_hsa000400.24382404
157Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.23731585
158Sulfur metabolism_Homo sapiens_hsa009200.23642846
159Retinol metabolism_Homo sapiens_hsa008300.22928443
160Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.22006905
161Fatty acid metabolism_Homo sapiens_hsa012120.21332258
162Allograft rejection_Homo sapiens_hsa053300.20674052

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