METTL22

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.45176405
2ATP synthesis coupled proton transport (GO:0015986)5.92425960
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.92425960
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.79696944
5behavioral response to nicotine (GO:0035095)5.45666729
6respiratory electron transport chain (GO:0022904)5.37048067
7electron transport chain (GO:0022900)5.28112639
8oxidative phosphorylation (GO:0006119)4.88737333
9muscle filament sliding (GO:0030049)4.81993015
10actin-myosin filament sliding (GO:0033275)4.81993015
11mitochondrial respiratory chain complex I assembly (GO:0032981)4.74537039
12NADH dehydrogenase complex assembly (GO:0010257)4.74537039
13mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.74537039
14protein complex biogenesis (GO:0070271)4.58844922
15chaperone-mediated protein transport (GO:0072321)4.56780544
16response to pheromone (GO:0019236)4.55265456
17L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.48467683
18cullin deneddylation (GO:0010388)4.46983739
19mitochondrial respiratory chain complex assembly (GO:0033108)4.30848852
20pyrimidine nucleobase catabolic process (GO:0006208)4.30305369
21proteasome assembly (GO:0043248)4.26406933
22protein deneddylation (GO:0000338)4.14444217
23ubiquinone biosynthetic process (GO:0006744)4.07213737
24quinone biosynthetic process (GO:1901663)4.07213737
25tricarboxylic acid cycle (GO:0006099)4.04981192
26regulation of cellular respiration (GO:0043457)3.83056992
27regulation of mitochondrial translation (GO:0070129)3.75010765
28ubiquinone metabolic process (GO:0006743)3.72492199
29epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68083448
30sarcoplasmic reticulum calcium ion transport (GO:0070296)3.66358345
31regulation of acyl-CoA biosynthetic process (GO:0050812)3.64722147
32heart process (GO:0003015)3.64511392
33heart contraction (GO:0060047)3.64511392
34inner mitochondrial membrane organization (GO:0007007)3.63044835
35purine nucleoside triphosphate biosynthetic process (GO:0009145)3.62673684
36GTP biosynthetic process (GO:0006183)3.62508049
37purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.61172316
38ATP biosynthetic process (GO:0006754)3.60790678
39actin-mediated cell contraction (GO:0070252)3.60494199
40regulation of cilium movement (GO:0003352)3.59033180
41polyketide metabolic process (GO:0030638)3.58397301
42doxorubicin metabolic process (GO:0044598)3.58397301
43daunorubicin metabolic process (GO:0044597)3.58397301
44negative regulation of telomere maintenance (GO:0032205)3.57433680
45protein targeting to mitochondrion (GO:0006626)3.55617741
46regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.54426492
47platelet dense granule organization (GO:0060155)3.52436548
48regulation of skeletal muscle contraction (GO:0014819)3.51881227
49aerobic respiration (GO:0009060)3.51550454
50amino acid salvage (GO:0043102)3.51077972
51L-methionine salvage (GO:0071267)3.51077972
52L-methionine biosynthetic process (GO:0071265)3.51077972
53sarcomere organization (GO:0045214)3.40104349
54establishment of protein localization to mitochondrion (GO:0072655)3.40036623
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.38504526
56L-fucose metabolic process (GO:0042354)3.38248532
57L-fucose catabolic process (GO:0042355)3.38248532
58fucose catabolic process (GO:0019317)3.38248532
59negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38085216
60skeletal muscle contraction (GO:0003009)3.37726451
61regulation of oxidative phosphorylation (GO:0002082)3.36408007
62guanosine-containing compound biosynthetic process (GO:1901070)3.36122333
63nucleobase catabolic process (GO:0046113)3.34770955
64DNA deamination (GO:0045006)3.34020629
65regulation of coenzyme metabolic process (GO:0051196)3.31570033
66regulation of cofactor metabolic process (GO:0051193)3.31570033
67protein polyglutamylation (GO:0018095)3.31356624
68regulation of cellular amino acid metabolic process (GO:0006521)3.31080288
69ribonucleoside triphosphate biosynthetic process (GO:0009201)3.29581685
70nonmotile primary cilium assembly (GO:0035058)3.28083301
71negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.27253228
72negative regulation of translation, ncRNA-mediated (GO:0040033)3.27253228
73regulation of translation, ncRNA-mediated (GO:0045974)3.27253228
74regulation of cell communication by electrical coupling (GO:0010649)3.25762816
75respiratory chain complex IV assembly (GO:0008535)3.23757819
76hydrogen ion transmembrane transport (GO:1902600)3.22790947
77peptidyl-histidine modification (GO:0018202)3.20229059
78water-soluble vitamin biosynthetic process (GO:0042364)3.17332856
79quinone metabolic process (GO:1901661)3.15813940
80protein localization to mitochondrion (GO:0070585)3.13746990
81regulation of telomere maintenance (GO:0032204)3.13701690
82NADH metabolic process (GO:0006734)3.12811339
83protein neddylation (GO:0045116)3.12420978
84detection of light stimulus involved in sensory perception (GO:0050962)3.12039176
85detection of light stimulus involved in visual perception (GO:0050908)3.12039176
86neural tube formation (GO:0001841)3.11585615
87establishment of protein localization to mitochondrial membrane (GO:0090151)3.11424245
88detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11320103
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10815454
90negative regulation of ligase activity (GO:0051352)3.10815454
91axoneme assembly (GO:0035082)3.10640940
92regulation of relaxation of muscle (GO:1901077)3.09990365
93positive regulation of mitochondrial fission (GO:0090141)3.08506914
94regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.08370654
95indolalkylamine metabolic process (GO:0006586)3.07568287
96UTP biosynthetic process (GO:0006228)3.06553678
97nucleoside triphosphate biosynthetic process (GO:0009142)3.05893700
98replication fork processing (GO:0031297)3.04946179
99neuronal action potential propagation (GO:0019227)3.03497070
100myofibril assembly (GO:0030239)3.02909494
101epithelial cilium movement (GO:0003351)2.99531834
102positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.99326983
103protein-cofactor linkage (GO:0018065)2.99077433
104retinal cone cell development (GO:0046549)2.98485275
105purine nucleoside monophosphate biosynthetic process (GO:0009127)2.98242032
106purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.98242032
107cytochrome complex assembly (GO:0017004)2.97503120
108regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.94659308
109metallo-sulfur cluster assembly (GO:0031163)2.94220746
110iron-sulfur cluster assembly (GO:0016226)2.94220746
111DNA double-strand break processing (GO:0000729)2.93271434
112CTP metabolic process (GO:0046036)2.93171465
113CTP biosynthetic process (GO:0006241)2.93171465
114regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92837350
115mitochondrial transport (GO:0006839)2.92477529
116photoreceptor cell maintenance (GO:0045494)2.90898494
117nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.90681582
118positive regulation of protein homodimerization activity (GO:0090073)2.90160255
119purine nucleotide salvage (GO:0032261)2.89097503
120gamma-aminobutyric acid transport (GO:0015812)2.88543541
121cornea development in camera-type eye (GO:0061303)2.88067996
122striated muscle contraction (GO:0006941)2.87677969
123negative regulation of transcription regulatory region DNA binding (GO:2000678)2.84986968
124DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84898659
125succinate metabolic process (GO:0006105)2.84592783
126proton transport (GO:0015992)2.83744435
127head development (GO:0060322)2.83389423
128protein localization to cilium (GO:0061512)2.82148373
129RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.80686171
130preassembly of GPI anchor in ER membrane (GO:0016254)2.80338169
131synaptic transmission, cholinergic (GO:0007271)2.79908386
132sulfation (GO:0051923)2.79494382
133oxygen transport (GO:0015671)2.78932061
134regulation of hippo signaling (GO:0035330)2.78491677
135intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.78318092
136signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.78318092
137transcription elongation from RNA polymerase III promoter (GO:0006385)2.77240791
138termination of RNA polymerase III transcription (GO:0006386)2.77240791
139ribosomal small subunit assembly (GO:0000028)2.77208905
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.77053012
141hydrogen transport (GO:0006818)2.76854316
142anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.75129736
143regulation of posttranscriptional gene silencing (GO:0060147)2.73953487
144regulation of gene silencing by miRNA (GO:0060964)2.73953487
145regulation of gene silencing by RNA (GO:0060966)2.73953487
146GPI anchor metabolic process (GO:0006505)2.72995444
147regulation of hexokinase activity (GO:1903299)2.65078496
148regulation of glucokinase activity (GO:0033131)2.65078496
149pseudouridine synthesis (GO:0001522)2.64237149
150cilium morphogenesis (GO:0060271)2.63718175
151kidney morphogenesis (GO:0060993)2.63213855
152regulation of mitotic spindle checkpoint (GO:1903504)2.61983152
153regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.61983152
154mannosylation (GO:0097502)2.61732398
155DNA damage response, detection of DNA damage (GO:0042769)2.61694670
156regulation of nuclear cell cycle DNA replication (GO:0033262)2.58498122
157tryptophan catabolic process (GO:0006569)2.58317554
158indole-containing compound catabolic process (GO:0042436)2.58317554
159indolalkylamine catabolic process (GO:0046218)2.58317554
160recombinational repair (GO:0000725)2.55871677
161double-strand break repair via homologous recombination (GO:0000724)2.55128428
162limb bud formation (GO:0060174)2.54048965
163cell proliferation in forebrain (GO:0021846)2.53186402
164regulation of microtubule-based movement (GO:0060632)2.52555482
165cellular biogenic amine catabolic process (GO:0042402)2.51950679
166amine catabolic process (GO:0009310)2.51950679
167negative regulation of response to food (GO:0032096)2.51704845
168negative regulation of appetite (GO:0032099)2.51704845
169positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.49003144
170presynaptic membrane assembly (GO:0097105)2.48637152
171kynurenine metabolic process (GO:0070189)2.48052217
172maturation of 5.8S rRNA (GO:0000460)2.46759560
173negative regulation of heart rate (GO:0010459)2.46344271
174tRNA processing (GO:0008033)2.46197664
175retinal ganglion cell axon guidance (GO:0031290)2.44432158
176negative regulation of DNA-dependent DNA replication (GO:2000104)2.44326293
177sperm motility (GO:0030317)2.44072673
178S-adenosylmethionine metabolic process (GO:0046500)2.43611394

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.27868718
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.00946054
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79153707
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.56849322
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.51676762
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39663237
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.37286791
8ETS1_20019798_ChIP-Seq_JURKAT_Human3.34390525
9EZH2_22144423_ChIP-Seq_EOC_Human3.30976889
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.20474501
11MYC_18555785_ChIP-Seq_MESCs_Mouse3.10732776
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.99774161
13THAP11_20581084_ChIP-Seq_MESCs_Mouse2.77986269
14SRF_21415370_ChIP-Seq_HL-1_Mouse2.75515937
15ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.68543283
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65779379
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.62038789
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.52028416
19PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.50114066
20YY1_21170310_ChIP-Seq_MESCs_Mouse2.47687119
21IGF1R_20145208_ChIP-Seq_DFB_Human2.43740696
22GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.39456060
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.33686914
24BP1_19119308_ChIP-ChIP_Hs578T_Human2.28441884
25EWS_26573619_Chip-Seq_HEK293_Human2.13187798
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11207590
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.04149324
28VDR_23849224_ChIP-Seq_CD4+_Human1.99380628
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.99147153
30POU3F2_20337985_ChIP-ChIP_501MEL_Human1.95135655
31ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.94966969
32FUS_26573619_Chip-Seq_HEK293_Human1.91450567
33EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.90844832
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87401144
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.84077912
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.79360528
37DCP1A_22483619_ChIP-Seq_HELA_Human1.78867291
38P300_19829295_ChIP-Seq_ESCs_Human1.77588430
39ELF1_17652178_ChIP-ChIP_JURKAT_Human1.75687035
40FOXP3_21729870_ChIP-Seq_TREG_Human1.73367573
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73037028
42GABP_19822575_ChIP-Seq_HepG2_Human1.70605805
43ER_23166858_ChIP-Seq_MCF-7_Human1.69499971
44XRN2_22483619_ChIP-Seq_HELA_Human1.68136621
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.68104248
46SALL1_21062744_ChIP-ChIP_HESCs_Human1.67884033
47BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.66958907
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62412935
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60022717
50TP53_22573176_ChIP-Seq_HFKS_Human1.56174917
51TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.49987736
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.49022824
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.48680132
54GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.45594764
55LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.44727503
56MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44472857
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44316075
58MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.43124356
59BCAT_22108803_ChIP-Seq_LS180_Human1.40624364
60CTCF_18555785_ChIP-Seq_MESCs_Mouse1.40399881
61CBP_20019798_ChIP-Seq_JUKART_Human1.40390045
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.40390045
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39113876
64* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.38806305
65PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.38195133
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.37531140
67SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36386713
68TTF2_22483619_ChIP-Seq_HELA_Human1.34449841
69ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.34016237
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33085014
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33085014
72ETV2_25802403_ChIP-Seq_MESCs_Mouse1.32500480
73TAF15_26573619_Chip-Seq_HEK293_Human1.32398020
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31428387
75BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31086509
76AR_25329375_ChIP-Seq_VCAP_Human1.26149733
77STAT3_23295773_ChIP-Seq_U87_Human1.25876988
78ZNF274_21170338_ChIP-Seq_K562_Hela1.24919013
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23562060
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.21744200
81IRF1_19129219_ChIP-ChIP_H3396_Human1.21608516
82TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.21468811
83RNF2_27304074_Chip-Seq_NSC_Mouse1.21033860
84POU5F1_16153702_ChIP-ChIP_HESCs_Human1.18884530
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18052533
86RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17150322
87TCF4_23295773_ChIP-Seq_U87_Human1.16843825
88PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15761257
89SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.15635079
90GATA3_21878914_ChIP-Seq_MCF-7_Human1.15583872
91SMAD4_21799915_ChIP-Seq_A2780_Human1.15274944
92YY1_22570637_ChIP-Seq_MALME-3M_Human1.14706446
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14435627
94NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13992630
95NCOR_22424771_ChIP-Seq_293T_Human1.12426421
96CIITA_25753668_ChIP-Seq_RAJI_Human1.12150511
97CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12001003
98SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.11938137
99TCF4_22108803_ChIP-Seq_LS180_Human1.11801579
100TP63_19390658_ChIP-ChIP_HaCaT_Human1.11589048
101NANOG_19829295_ChIP-Seq_ESCs_Human1.11399591
102SOX2_19829295_ChIP-Seq_ESCs_Human1.11399591
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.11015861
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09916733
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.09355208
106AR_20517297_ChIP-Seq_VCAP_Human1.09235566
107SUZ12_27294783_Chip-Seq_NPCs_Mouse1.09171503
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08834045
109EZH2_27294783_Chip-Seq_NPCs_Mouse1.08822944
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.08738857
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.08738857
112MYC_18940864_ChIP-ChIP_HL60_Human1.08306833
113HOXB7_26014856_ChIP-Seq_BT474_Human1.07461438
114NFE2_27457419_Chip-Seq_LIVER_Mouse1.06449612
115NELFA_20434984_ChIP-Seq_ESCs_Mouse1.06336466
116REST_18959480_ChIP-ChIP_MESCs_Mouse1.05422401
117* REST_21632747_ChIP-Seq_MESCs_Mouse1.04395414
118EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.04244546
119RUNX2_22187159_ChIP-Seq_PCA_Human1.04226867
120GBX2_23144817_ChIP-Seq_PC3_Human1.03395153
121CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.03061658
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02783991
123ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01171361
124NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00341375
125FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00094457
126TOP2B_26459242_ChIP-Seq_MCF-7_Human0.99772280
127CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.99655216
128HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99090165
129SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98096918
130MYC_19829295_ChIP-Seq_ESCs_Human0.96083291
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.95666145
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.94984207
133CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93880465
134ERA_21632823_ChIP-Seq_H3396_Human0.93781778
135FLI1_21867929_ChIP-Seq_TH2_Mouse0.93240916
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93086433
137ELK1_19687146_ChIP-ChIP_HELA_Human0.92610691
138HTT_18923047_ChIP-ChIP_STHdh_Human0.91412048
139CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91044936
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.89771930
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.89541896
142ZFX_18555785_ChIP-Seq_MESCs_Mouse0.86355982
143SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.85746213
144VDR_22108803_ChIP-Seq_LS180_Human0.83039295
145MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.81697313
146PCGF2_27294783_Chip-Seq_ESCs_Mouse0.81050038
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80951222
148NANOG_18555785_ChIP-Seq_MESCs_Mouse0.79511110
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.77908376
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.77847970
151PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.77280515
152TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76731591
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.75990639
154ELK1_22589737_ChIP-Seq_MCF10A_Human0.74228305
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74145816
156NANOG_20526341_ChIP-Seq_ESCs_Human0.73303706
157TET1_21451524_ChIP-Seq_MESCs_Mouse0.73224805
158KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.72396310
159SOX2_22085726_ChIP-Seq_NPCs_Mouse0.71572621
160RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.69423455
161FOXP1_21924763_ChIP-Seq_HESCs_Human0.68103102
162ZFP57_27257070_Chip-Seq_ESCs_Mouse0.67741445
163MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.67648489
164STAT3_1855785_ChIP-Seq_MESCs_Mouse0.67624271

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue4.77669893
2MP0000749_muscle_degeneration3.91618521
3MP0004145_abnormal_muscle_electrophysio3.82627543
4MP0000751_myopathy3.65098216
5MP0002837_dystrophic_cardiac_calcinosis3.58460807
6MP0004036_abnormal_muscle_relaxation3.15427578
7MP0002653_abnormal_ependyma_morphology3.13665349
8MP0003787_abnormal_imprinting2.90602728
9MP0006036_abnormal_mitochondrial_physio2.83278290
10MP0003880_abnormal_central_pattern2.72428404
11MP0004084_abnormal_cardiac_muscle2.61237031
12MP0004215_abnormal_myocardial_fiber2.60536783
13MP0002102_abnormal_ear_morphology2.57105649
14MP0003806_abnormal_nucleotide_metabolis2.47543062
15MP0006276_abnormal_autonomic_nervous2.33301197
16MP0003195_calcinosis2.31423114
17MP0001529_abnormal_vocalization2.30441971
18MP0002106_abnormal_muscle_physiology2.26785927
19MP0005551_abnormal_eye_electrophysiolog2.14900856
20MP0006035_abnormal_mitochondrial_morpho2.14299114
21MP0000747_muscle_weakness2.12388568
22MP0001968_abnormal_touch/_nociception2.08991729
23MP0002736_abnormal_nociception_after2.07148324
24MP0004142_abnormal_muscle_tone1.99532569
25MP0008789_abnormal_olfactory_epithelium1.99426238
26MP0001905_abnormal_dopamine_level1.97637394
27MP0005330_cardiomyopathy1.84194629
28MP0005394_taste/olfaction_phenotype1.83387510
29MP0005499_abnormal_olfactory_system1.83387510
30MP0005369_muscle_phenotype1.81172315
31MP0000759_abnormal_skeletal_muscle1.81045973
32MP0002735_abnormal_chemical_nociception1.77759741
33MP0005620_abnormal_muscle_contractility1.77244628
34MP0002269_muscular_atrophy1.74725275
35MP0003121_genomic_imprinting1.72805656
36MP0004147_increased_porphyrin_level1.69801483
37MP0003137_abnormal_impulse_conducting1.69607158
38MP0003136_yellow_coat_color1.66807753
39MP0005410_abnormal_fertilization1.65692664
40MP0005645_abnormal_hypothalamus_physiol1.60716120
41MP0000750_abnormal_muscle_regeneration1.60264250
42MP0001986_abnormal_taste_sensitivity1.59727282
43MP0003656_abnormal_erythrocyte_physiolo1.58859098
44MP0002638_abnormal_pupillary_reflex1.56479152
45MP0004087_abnormal_muscle_fiber1.56022140
46MP0001485_abnormal_pinna_reflex1.50784340
47MP0004859_abnormal_synaptic_plasticity1.50559443
48MP0002822_catalepsy1.49918346
49MP0002938_white_spotting1.47398070
50MP0002272_abnormal_nervous_system1.46798514
51MP0009745_abnormal_behavioral_response1.46568029
52MP0009046_muscle_twitch1.45194640
53MP0004484_altered_response_of1.44595451
54MP0002332_abnormal_exercise_endurance1.44110604
55MP0004270_analgesia1.42215837
56MP0005253_abnormal_eye_physiology1.41091906
57MP0003635_abnormal_synaptic_transmissio1.39540404
58MP0002064_seizures1.38614317
59MP0006072_abnormal_retinal_apoptosis1.38357704
60MP0002972_abnormal_cardiac_muscle1.38244262
61MP0006292_abnormal_olfactory_placode1.37151720
62MP0008058_abnormal_DNA_repair1.34970970
63MP0008995_early_reproductive_senescence1.33799675
64MP0002751_abnormal_autonomic_nervous1.33261876
65MP0004130_abnormal_muscle_cell1.33209669
66MP0002067_abnormal_sensory_capabilities1.31751143
67MP0003011_delayed_dark_adaptation1.31008323
68MP0005083_abnormal_biliary_tract1.27334702
69MP0004043_abnormal_pH_regulation1.27314640
70MP0002572_abnormal_emotion/affect_behav1.26842660
71MP0002734_abnormal_mechanical_nocicepti1.26008725
72MP0005266_abnormal_metabolism1.22237092
73MP0005377_hearing/vestibular/ear_phenot1.21060064
74MP0003878_abnormal_ear_physiology1.21060064
75MP0005084_abnormal_gallbladder_morpholo1.19461489
76MP0008260_abnormal_autophagy1.19444995
77MP0001440_abnormal_grooming_behavior1.19324887
78MP0000778_abnormal_nervous_system1.18015137
79MP0004924_abnormal_behavior1.17988685
80MP0005386_behavior/neurological_phenoty1.17988685
81MP0008875_abnormal_xenobiotic_pharmacok1.17636515
82MP0000631_abnormal_neuroendocrine_gland1.15354403
83MP0004233_abnormal_muscle_weight1.14701704
84MP0003718_maternal_effect1.13341929
85MP0002160_abnormal_reproductive_system1.13120298
86MP0009697_abnormal_copulation1.12448377
87MP0004085_abnormal_heartbeat1.09170421
88MP0003221_abnormal_cardiomyocyte_apopto1.09142144
89MP0002127_abnormal_cardiovascular_syste1.07676146
90MP0006054_spinal_hemorrhage1.05811066
91MP0002063_abnormal_learning/memory/cond1.05764303
92MP0003890_abnormal_embryonic-extraembry1.05466222
93MP0001293_anophthalmia1.05203016
94MP0001970_abnormal_pain_threshold1.04313243
95MP0002752_abnormal_somatic_nervous1.03544775
96MP0000049_abnormal_middle_ear1.03170966
97MP0005646_abnormal_pituitary_gland1.03082942
98MP0000427_abnormal_hair_cycle1.02849338
99MP0000372_irregular_coat_pigmentation1.02485749
100MP0005075_abnormal_melanosome_morpholog1.01896490
101MP0005389_reproductive_system_phenotype1.00243242
102MP0005423_abnormal_somatic_nervous0.99998000
103MP0003122_maternal_imprinting0.99586616
104MP0002163_abnormal_gland_morphology0.99527229
105MP0002733_abnormal_thermal_nociception0.99240496
106MP0001544_abnormal_cardiovascular_syste0.98419741
107MP0005385_cardiovascular_system_phenoty0.98419741
108MP0005195_abnormal_posterior_eye0.96705757
109MP0009379_abnormal_foot_pigmentation0.95016346
110MP0003879_abnormal_hair_cell0.92374002
111MP0001188_hyperpigmentation0.90140505
112MP0008569_lethality_at_weaning0.88653026
113MP0008775_abnormal_heart_ventricle0.88390446
114MP0008872_abnormal_physiological_respon0.87916438
115MP0001764_abnormal_homeostasis0.87549504
116MP0002254_reproductive_system_inflammat0.86434054
117MP0001486_abnormal_startle_reflex0.83609986
118MP0001929_abnormal_gametogenesis0.83293179
119MP0003119_abnormal_digestive_system0.82035379
120MP0004742_abnormal_vestibular_system0.81490663
121MP0002066_abnormal_motor_capabilities/c0.81436798
122MP0000230_abnormal_systemic_arterial0.79911887
123MP0002210_abnormal_sex_determination0.79531672
124MP0002234_abnormal_pharynx_morphology0.78476549
125MP0005367_renal/urinary_system_phenotyp0.78306330
126MP0000516_abnormal_urinary_system0.78306330
127MP0004885_abnormal_endolymph0.78261696
128MP0000026_abnormal_inner_ear0.76870674
129MP0005167_abnormal_blood-brain_barrier0.76631436
130MP0006138_congestive_heart_failure0.76353465
131MP0002184_abnormal_innervation0.76196331
132MP0000358_abnormal_cell_content/0.75671421
133MP0002876_abnormal_thyroid_physiology0.72679855
134MP0003186_abnormal_redox_activity0.69746611
135MP0003698_abnormal_male_reproductive0.68174675
136MP0004957_abnormal_blastocyst_morpholog0.65777638
137MP0001502_abnormal_circadian_rhythm0.65563287
138MP0002229_neurodegeneration0.64561633
139MP0000343_altered_response_to0.63130554
140MP0005376_homeostasis/metabolism_phenot0.62066011
141MP0001984_abnormal_olfaction0.61508926
142MP0005535_abnormal_body_temperature0.61310466
143MP0002557_abnormal_social/conspecific_i0.61252447
144MP0001501_abnormal_sleep_pattern0.59746522
145MP0010630_abnormal_cardiac_muscle0.59224054
146MP0008877_abnormal_DNA_methylation0.55184680
147MP0003693_abnormal_embryo_hatching0.53320905
148MP0004811_abnormal_neuron_physiology0.52862426
149MP0001963_abnormal_hearing_physiology0.49423276
150MP0004133_heterotaxia0.48531534

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)5.49579537
2Abnormal mitochondria in muscle tissue (HP:0008316)5.27422954
3Mitochondrial inheritance (HP:0001427)4.86003015
4Hepatocellular necrosis (HP:0001404)4.69517446
5Muscle hypertrophy of the lower extremities (HP:0008968)4.63848101
6Acute encephalopathy (HP:0006846)4.49594980
7Increased CSF lactate (HP:0002490)4.49243006
8Exercise-induced myalgia (HP:0003738)4.43512085
9Progressive macrocephaly (HP:0004481)4.40790190
10Muscle fiber inclusion bodies (HP:0100299)4.38570805
11Calf muscle hypertrophy (HP:0008981)4.35535378
12Exercise-induced muscle cramps (HP:0003710)4.33833732
13Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.25383255
14Hepatic necrosis (HP:0002605)4.18297604
15Nemaline bodies (HP:0003798)4.15689762
16Pancreatic cysts (HP:0001737)3.96868505
17Pancreatic fibrosis (HP:0100732)3.67962202
18Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.64109861
19Decreased activity of mitochondrial respiratory chain (HP:0008972)3.64109861
20Exercise intolerance (HP:0003546)3.61921554
21Chronic hepatic failure (HP:0100626)3.61212394
22Increased hepatocellular lipid droplets (HP:0006565)3.60559327
23True hermaphroditism (HP:0010459)3.50132471
24Abnormality of midbrain morphology (HP:0002418)3.49802904
25Molar tooth sign on MRI (HP:0002419)3.49802904
26Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.48780569
27Lactic acidosis (HP:0003128)3.48437387
28Abnormality of glycolysis (HP:0004366)3.47390788
29Increased serum pyruvate (HP:0003542)3.47390788
30Increased serum lactate (HP:0002151)3.46264628
31Lipid accumulation in hepatocytes (HP:0006561)3.35683394
32Increased intramyocellular lipid droplets (HP:0012240)3.35379550
333-Methylglutaconic aciduria (HP:0003535)3.35367328
34Medial flaring of the eyebrow (HP:0010747)3.33568283
35Cerebral edema (HP:0002181)3.32954941
36Myotonia (HP:0002486)3.32751451
37Abnormality of alanine metabolism (HP:0010916)3.26445341
38Hyperalaninemia (HP:0003348)3.26445341
39Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.26445341
40Nephronophthisis (HP:0000090)3.23219967
41Progressive inability to walk (HP:0002505)3.22259898
42Congenital stationary night blindness (HP:0007642)3.20399829
43Myoglobinuria (HP:0002913)3.20151892
44Abnormality of the labia minora (HP:0012880)3.09885273
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.06235405
46Rhabdomyolysis (HP:0003201)3.02890158
47Increased muscle lipid content (HP:0009058)3.01059134
48Respiratory failure (HP:0002878)2.97223711
49Neuroendocrine neoplasm (HP:0100634)2.96852275
50Abnormality of the renal cortex (HP:0011035)2.93521230
51Renal Fanconi syndrome (HP:0001994)2.90013365
52Inability to walk (HP:0002540)2.89284461
53Sudden death (HP:0001699)2.88134412
54Optic disc pallor (HP:0000543)2.87843484
55Lissencephaly (HP:0001339)2.86492988
56Abnormality of the calf musculature (HP:0001430)2.85827387
57Myopathic facies (HP:0002058)2.84177910
58Abnormality of the renal medulla (HP:0100957)2.83548936
59Distal arthrogryposis (HP:0005684)2.81762992
60Gait imbalance (HP:0002141)2.80440561
61Congenital primary aphakia (HP:0007707)2.76126453
62Type II lissencephaly (HP:0007260)2.73654349
63Leukodystrophy (HP:0002415)2.72863681
64EMG: myopathic abnormalities (HP:0003458)2.72156137
65Nephrogenic diabetes insipidus (HP:0009806)2.66705358
66Focal motor seizures (HP:0011153)2.66082644
67Muscle stiffness (HP:0003552)2.65496209
68Ragged-red muscle fibers (HP:0003200)2.64680865
69Rimmed vacuoles (HP:0003805)2.62957899
70Muscle fiber splitting (HP:0003555)2.60939711
71Pheochromocytoma (HP:0002666)2.54817038
72Pendular nystagmus (HP:0012043)2.54190045
73Cystic liver disease (HP:0006706)2.53273766
74Type 1 muscle fiber predominance (HP:0003803)2.51410018
75CNS demyelination (HP:0007305)2.42134428
76Abnormality of the heme biosynthetic pathway (HP:0010472)2.41890279
77Renal cortical cysts (HP:0000803)2.41058992
78Emotional lability (HP:0000712)2.39613437
79Respiratory difficulties (HP:0002880)2.39299366
80Genital tract atresia (HP:0001827)2.39193723
81Poor suck (HP:0002033)2.34790125
82Vaginal atresia (HP:0000148)2.34575221
83Attenuation of retinal blood vessels (HP:0007843)2.31013077
84Anencephaly (HP:0002323)2.30667760
85Abolished electroretinogram (ERG) (HP:0000550)2.28080374
86Sclerocornea (HP:0000647)2.28035696
87Cerebral hypomyelination (HP:0006808)2.25584878
88Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.23053323
89Optic nerve hypoplasia (HP:0000609)2.22676939
90Progressive muscle weakness (HP:0003323)2.22665266
91Pachygyria (HP:0001302)2.22408087
92Tubular atrophy (HP:0000092)2.20321621
93Poor coordination (HP:0002370)2.18347628
94Muscle fiber atrophy (HP:0100295)2.17835508
95Polydipsia (HP:0001959)2.17741879
96Abnormal drinking behavior (HP:0030082)2.17741879
97Difficulty running (HP:0009046)2.16792685
98Absent/shortened dynein arms (HP:0200106)2.15616409
99Dynein arm defect of respiratory motile cilia (HP:0012255)2.15616409
100Anophthalmia (HP:0000528)2.13430387
101Intestinal atresia (HP:0011100)2.12620930
102Abnormal hair whorl (HP:0010721)2.12086136
103Unsteady gait (HP:0002317)2.11992545
104Type 2 muscle fiber atrophy (HP:0003554)2.11644731
105Hyperglycinuria (HP:0003108)2.11009626
106Patellar aplasia (HP:0006443)2.10835814
107Progressive cerebellar ataxia (HP:0002073)2.09922680
108Areflexia of lower limbs (HP:0002522)2.08406304
109Calcaneovalgus deformity (HP:0001848)2.08120564
110Colon cancer (HP:0003003)2.08027710
111Methylmalonic acidemia (HP:0002912)2.06992219
112Abnormality of cells of the erythroid lineage (HP:0012130)2.05981777
113Subaortic stenosis (HP:0001682)2.05396119
114Abnormality of the left ventricular outflow tract (HP:0011103)2.05396119
115Palpitations (HP:0001962)2.04157535
116Exertional dyspnea (HP:0002875)2.03668656
117Abnormal number of erythroid precursors (HP:0012131)2.01412908
118Aplastic anemia (HP:0001915)2.00074687
119Gaze-evoked nystagmus (HP:0000640)1.97572807
120Neck muscle weakness (HP:0000467)1.97550346
121Aplasia/Hypoplasia of the uvula (HP:0010293)1.97415562
122Aplasia/Hypoplasia of the patella (HP:0006498)1.96538059
123Lethargy (HP:0001254)1.96082173
124Broad-based gait (HP:0002136)1.95799246
125Ectopic kidney (HP:0000086)1.95027974
126Hyperglycinemia (HP:0002154)1.93063834
127Aplasia/Hypoplasia of the tibia (HP:0005772)1.92400081
128Bilateral microphthalmos (HP:0007633)1.91827335
129Methylmalonic aciduria (HP:0012120)1.91725773
130Abnormality of DNA repair (HP:0003254)1.91581800
131Myokymia (HP:0002411)1.91028818
132Ventricular tachycardia (HP:0004756)1.90260571
133Male pseudohermaphroditism (HP:0000037)1.90044677
134Aplasia/Hypoplasia of the tongue (HP:0010295)1.90028769
135Congenital hepatic fibrosis (HP:0002612)1.88665826
136Supraventricular tachycardia (HP:0004755)1.88456035
137Decreased central vision (HP:0007663)1.88255973
138Hyperventilation (HP:0002883)1.88088512
139Abnormal rod and cone electroretinograms (HP:0008323)1.88069069
140Genetic anticipation (HP:0003743)1.86949286
141Lipoatrophy (HP:0100578)1.86905622
142Neoplasm of the peripheral nervous system (HP:0100007)1.86441942
143Polyuria (HP:0000103)1.86436623
144Absent thumb (HP:0009777)1.86106260
145Microvesicular hepatic steatosis (HP:0001414)1.85616607
146Round ear (HP:0100830)1.84984368
147Cholecystitis (HP:0001082)1.84458060
148Abnormal gallbladder physiology (HP:0012438)1.84458060
149Bile duct proliferation (HP:0001408)1.83778052
150Abnormal biliary tract physiology (HP:0012439)1.83778052
151Abnormality of the ileum (HP:0001549)1.83006402
152Retinal dysplasia (HP:0007973)1.82957326
153Specific learning disability (HP:0001328)1.82557722
154Abnormality of the renal collecting system (HP:0004742)1.81012034
155Postaxial hand polydactyly (HP:0001162)1.80822072
156Dandy-Walker malformation (HP:0001305)1.79704494
157Drooling (HP:0002307)1.79068901
158Primary atrial arrhythmia (HP:0001692)1.79002382
159Progressive external ophthalmoplegia (HP:0000590)1.78678144
160Atrial fibrillation (HP:0005110)1.78336231
161Meckel diverticulum (HP:0002245)1.78184449
162Deformed tarsal bones (HP:0008119)1.78072061
163Supraventricular arrhythmia (HP:0005115)1.77197010
164Dilated cardiomyopathy (HP:0001644)1.77195340
165Duplicated collecting system (HP:0000081)1.76627885
166Abnormal respiratory motile cilium morphology (HP:0005938)1.75253597
167Abnormal respiratory epithelium morphology (HP:0012253)1.75253597
168Abnormality of the vocal cords (HP:0008777)1.74631594
169Delusions (HP:0000746)1.74603329
170Tinnitus (HP:0000360)1.74551527
171Supernumerary spleens (HP:0009799)1.74309460
172Increased corneal curvature (HP:0100692)1.73803864
173Keratoconus (HP:0000563)1.73803864
174Abnormality of glycine metabolism (HP:0010895)1.73186670
175Abnormality of serine family amino acid metabolism (HP:0010894)1.73186670
176Disproportionate short-trunk short stature (HP:0003521)1.72777110
177Type I transferrin isoform profile (HP:0003642)1.72395635
178X-linked dominant inheritance (HP:0001423)1.71862061
179Left ventricular hypertrophy (HP:0001712)1.71705905
180Postaxial foot polydactyly (HP:0001830)1.71123968
181Hyporeflexia of lower limbs (HP:0002600)1.70108649
182Gliosis (HP:0002171)1.69178101
183Aganglionic megacolon (HP:0002251)1.68437106

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.65962327
2OBSCN4.25765809
3MUSK3.79258700
4MAP4K23.35581949
5MAP3K123.23205696
6NME13.16760547
7WNK32.81458787
8PHKG22.55956158
9PHKG12.55956158
10STK162.53704215
11PDK42.52265547
12PDK32.52265547
13CASK2.50752357
14EIF2AK12.44405978
15TRIM282.40600992
16NUAK12.28900426
17BCKDK2.22807132
18WNK42.17040049
19MAP2K72.16091721
20CDK192.07062701
21BUB12.06180036
22NME21.98504246
23GRK11.93113725
24CCNB11.91787953
25MYLK1.81336696
26STK241.75306356
27GRK51.74638574
28INSRR1.69989598
29NEK11.69949141
30MAP2K41.64662233
31PASK1.57233932
32PDK21.57163506
33GRK71.54103755
34TTN1.51965740
35SIK21.44006808
36MAP2K31.36376854
37PINK11.33809991
38VRK11.33126609
39MAPK121.28863995
40BCR1.22829269
41MAP2K61.21906306
42ADRBK21.20891357
43TLK11.20483989
44CDK81.18725377
45ZAK1.18426671
46DAPK11.14804041
47TSSK61.14396919
48OXSR11.14186587
49ACVR1B1.12985495
50ARAF1.10688779
51BMPR1B1.09145065
52TAOK31.08072800
53MAP3K111.05753926
54MAP3K41.04035886
55EIF2AK31.01987729
56MAPK131.00881459
57ILK1.00401004
58PAK31.00251638
59TGFBR10.99914932
60SRPK10.99033904
61MAPKAPK30.98856888
62PIM20.93893593
63DYRK20.93560574
64VRK20.93231525
65TNIK0.92439727
66NEK20.89124020
67BRAF0.88710300
68DAPK30.86784228
69NTRK30.82852713
70MARK10.81817202
71WEE10.79689909
72CSNK1G10.74323806
73STK390.73756005
74PLK30.72898751
75MINK10.72831968
76CSNK1G20.72793368
77MAPKAPK50.71458730
78FGFR20.71115260
79PIK3CA0.67981772
80TEC0.67836170
81DAPK20.67599434
82DYRK30.66190087
83CSNK1A1L0.65618948
84BRSK20.64822171
85STK38L0.64122017
86CAMK2A0.59644603
87FLT30.58652014
88LMTK20.57422457
89EPHB20.55945212
90PRKCE0.55851917
91PTK2B0.55310828
92CAMK2G0.55195205
93AURKA0.54898333
94CAMKK20.54189406
95ADRBK10.52243217
96GRK60.52139492
97PRKCG0.52135993
98PLK40.51709100
99TXK0.51163934
100CAMK2D0.51118857
101RPS6KA50.50674647
102MAP3K70.50461724
103KDR0.50079034
104CSNK1G30.49978291
105DYRK1B0.49650011
106MAP3K50.49632571
107PLK10.49404316
108NTRK20.49345408
109SIK30.49271061
110TYRO30.48213721
111TESK10.47828288
112PRKAA10.47488521
113DYRK1A0.45846839
114FES0.45735532
115STK110.45434899
116ERBB30.45325524
117MKNK10.44862116
118PRKCZ0.44093986
119CDK180.44058277
120LIMK10.43552645
121CDK140.43283498
122PRKACA0.43020539
123PIK3CG0.42770449
124TIE10.42086096
125CAMK2B0.42008023
126SYK0.41951870
127EPHA40.41369678
128PRKCQ0.41194488
129CDK150.41053116
130MAPK40.40608792
131IKBKB0.39885678
132CDK11A0.39823523
133ATR0.39670049
134SGK2230.39637163
135SGK4940.39637163
136CAMKK10.38842760
137TAOK20.37991764
138PRKG20.36821031
139RPS6KA40.36446615
140CSNK1A10.35615597
141PRKAA20.35129532
142MAP3K60.34505075
143MKNK20.34436568
144STK30.34267815
145PRKG10.33431505
146CAMK10.32077276
147PRKACB0.31474010
148PKN10.31428603
149AKT30.30256395
150CSNK2A20.29720441
151CAMK40.28163792
152ABL20.27158946
153TNK20.26563117
154PLK20.26501807

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.23613722
2Parkinsons disease_Homo sapiens_hsa050124.78953262
3Proteasome_Homo sapiens_hsa030503.87589876
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.55678556
5Alzheimers disease_Homo sapiens_hsa050103.41358000
6Cardiac muscle contraction_Homo sapiens_hsa042603.40240423
7Huntingtons disease_Homo sapiens_hsa050163.36845078
8Ribosome_Homo sapiens_hsa030102.99553392
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.71857054
10Phototransduction_Homo sapiens_hsa047442.45158987
11RNA polymerase_Homo sapiens_hsa030202.31644934
12Nitrogen metabolism_Homo sapiens_hsa009102.19081925
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.01916669
14Selenocompound metabolism_Homo sapiens_hsa004502.00514970
152-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.93395693
16Pyruvate metabolism_Homo sapiens_hsa006201.82196209
17Propanoate metabolism_Homo sapiens_hsa006401.80892956
18Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.74168144
19Carbon metabolism_Homo sapiens_hsa012001.70344873
20Steroid biosynthesis_Homo sapiens_hsa001001.61819565
21Nicotine addiction_Homo sapiens_hsa050331.59698553
22Pyrimidine metabolism_Homo sapiens_hsa002401.56217776
23DNA replication_Homo sapiens_hsa030301.55119060
24Fatty acid elongation_Homo sapiens_hsa000621.53193289
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.50673767
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49434089
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.38911143
28Collecting duct acid secretion_Homo sapiens_hsa049661.36958497
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.34658928
30Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.31125845
31Non-homologous end-joining_Homo sapiens_hsa034501.29869441
32Tryptophan metabolism_Homo sapiens_hsa003801.27664493
33Synaptic vesicle cycle_Homo sapiens_hsa047211.27049056
34Purine metabolism_Homo sapiens_hsa002301.26153549
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.24997656
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.20529983
37Biosynthesis of amino acids_Homo sapiens_hsa012301.19092080
38Mismatch repair_Homo sapiens_hsa034301.17194755
39Homologous recombination_Homo sapiens_hsa034401.15181893
40Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15057727
41Vitamin B6 metabolism_Homo sapiens_hsa007501.13242285
42Basal transcription factors_Homo sapiens_hsa030221.10708996
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.10375985
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.09173170
45ABC transporters_Homo sapiens_hsa020101.08411467
46Pentose phosphate pathway_Homo sapiens_hsa000301.04947949
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.00907042
48Sulfur relay system_Homo sapiens_hsa041220.98523314
49Protein export_Homo sapiens_hsa030600.97572073
50Fructose and mannose metabolism_Homo sapiens_hsa000510.96778108
51Caffeine metabolism_Homo sapiens_hsa002320.95035363
52Nucleotide excision repair_Homo sapiens_hsa034200.94959857
53Spliceosome_Homo sapiens_hsa030400.94364652
54Metabolic pathways_Homo sapiens_hsa011000.91801223
55Dilated cardiomyopathy_Homo sapiens_hsa054140.91198393
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89249426
57RNA degradation_Homo sapiens_hsa030180.87484985
58Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.86158704
59Galactose metabolism_Homo sapiens_hsa000520.85634574
60Folate biosynthesis_Homo sapiens_hsa007900.85221383
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.85133608
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.84530801
63Regulation of autophagy_Homo sapiens_hsa041400.83988805
64Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83596375
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83469269
66Glycerolipid metabolism_Homo sapiens_hsa005610.81411955
67Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.80902747
68Base excision repair_Homo sapiens_hsa034100.80578726
69beta-Alanine metabolism_Homo sapiens_hsa004100.80276828
70Primary bile acid biosynthesis_Homo sapiens_hsa001200.79319106
71Calcium signaling pathway_Homo sapiens_hsa040200.78195310
72RNA transport_Homo sapiens_hsa030130.75389484
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.74542675
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67410801
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.67382238
76Insulin secretion_Homo sapiens_hsa049110.66609525
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66422922
78Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65929442
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.61830874
80Fat digestion and absorption_Homo sapiens_hsa049750.61555645
81Fatty acid metabolism_Homo sapiens_hsa012120.60534668
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.59831866
83Chemical carcinogenesis_Homo sapiens_hsa052040.58897305
84Ovarian steroidogenesis_Homo sapiens_hsa049130.57419153
85Fatty acid degradation_Homo sapiens_hsa000710.56858592
86Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.56203695
87Serotonergic synapse_Homo sapiens_hsa047260.55107082
88Vibrio cholerae infection_Homo sapiens_hsa051100.55012771
89GABAergic synapse_Homo sapiens_hsa047270.54810486
90Retinol metabolism_Homo sapiens_hsa008300.53843216
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52977166
92Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52324098
93Primary immunodeficiency_Homo sapiens_hsa053400.50735285
94Arginine and proline metabolism_Homo sapiens_hsa003300.48386890
95Circadian entrainment_Homo sapiens_hsa047130.46669030
96Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45575694
97Taste transduction_Homo sapiens_hsa047420.45302260
98Glucagon signaling pathway_Homo sapiens_hsa049220.44010228
99Morphine addiction_Homo sapiens_hsa050320.42965033
100Hedgehog signaling pathway_Homo sapiens_hsa043400.42721760
101Peroxisome_Homo sapiens_hsa041460.41021268
102Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.40309841
103Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.40288390
104p53 signaling pathway_Homo sapiens_hsa041150.39838314
105Oxytocin signaling pathway_Homo sapiens_hsa049210.37797786
106Dopaminergic synapse_Homo sapiens_hsa047280.35384915
107Butanoate metabolism_Homo sapiens_hsa006500.33742670
108Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.33455567
109Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33198447
110Glutamatergic synapse_Homo sapiens_hsa047240.32570913
111Amphetamine addiction_Homo sapiens_hsa050310.32566256
112Starch and sucrose metabolism_Homo sapiens_hsa005000.32370333
113Long-term potentiation_Homo sapiens_hsa047200.31931295
114Arachidonic acid metabolism_Homo sapiens_hsa005900.31696243
115Fatty acid biosynthesis_Homo sapiens_hsa000610.31158268
116One carbon pool by folate_Homo sapiens_hsa006700.31103406
117Ether lipid metabolism_Homo sapiens_hsa005650.29971995
118Linoleic acid metabolism_Homo sapiens_hsa005910.29862127
119Fanconi anemia pathway_Homo sapiens_hsa034600.29255426
120Cocaine addiction_Homo sapiens_hsa050300.28329989
121Olfactory transduction_Homo sapiens_hsa047400.28249935
122Vitamin digestion and absorption_Homo sapiens_hsa049770.27598315
123Axon guidance_Homo sapiens_hsa043600.26747533
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.23402076
125Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21960714
126Oocyte meiosis_Homo sapiens_hsa041140.21863184
127Epstein-Barr virus infection_Homo sapiens_hsa051690.21588482
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.20404611
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18754228
130Circadian rhythm_Homo sapiens_hsa047100.18259503
131Rheumatoid arthritis_Homo sapiens_hsa053230.17399647
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.15874088
133Long-term depression_Homo sapiens_hsa047300.15826016
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.12258395

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