METTL23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene functions as a transcription factor regulator in the transcriptional pathway for human cognition. It is a partner of the alpha subunit of the GA-binding protein transcription factor. Mutations in this gene cause mild autosomal recessive intellectual disability. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)6.47438246
2viral transcription (GO:0019083)6.27775100
3translational termination (GO:0006415)5.97410184
4ribosomal small subunit biogenesis (GO:0042274)5.80267436
5SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.58035837
6cotranslational protein targeting to membrane (GO:0006613)5.51135579
7ribosomal large subunit biogenesis (GO:0042273)5.49933121
8protein targeting to ER (GO:0045047)5.45563318
9protein localization to endoplasmic reticulum (GO:0070972)5.21725907
10establishment of protein localization to endoplasmic reticulum (GO:0072599)5.18105234
11translational elongation (GO:0006414)4.98994948
12DNA deamination (GO:0045006)4.83871968
13viral life cycle (GO:0019058)4.73720515
14cellular protein complex disassembly (GO:0043624)4.56138652
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.51509047
16proteasome assembly (GO:0043248)4.41893177
17nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.39217722
18ATP synthesis coupled proton transport (GO:0015986)4.19945771
19energy coupled proton transport, down electrochemical gradient (GO:0015985)4.19945771
20maturation of SSU-rRNA (GO:0030490)4.18066750
21translational initiation (GO:0006413)4.17291239
22base-excision repair, AP site formation (GO:0006285)3.91420250
23protein complex disassembly (GO:0043241)3.90825367
24deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.82458724
25macromolecular complex disassembly (GO:0032984)3.77698067
26translation (GO:0006412)3.77463958
27telomere maintenance via semi-conservative replication (GO:0032201)3.76043946
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.75958748
29protein neddylation (GO:0045116)3.67984737
30meiotic chromosome segregation (GO:0045132)3.61990150
31respiratory chain complex IV assembly (GO:0008535)3.58946749
32transcription elongation from RNA polymerase III promoter (GO:0006385)3.51741837
33termination of RNA polymerase III transcription (GO:0006386)3.51741837
34tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.51224667
35RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.51224667
36ribonucleoprotein complex biogenesis (GO:0022613)3.49280993
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.46699988
38protein targeting to membrane (GO:0006612)3.45833741
39purine deoxyribonucleotide catabolic process (GO:0009155)3.45730783
40deoxyribose phosphate catabolic process (GO:0046386)3.43656266
41respiratory electron transport chain (GO:0022904)3.43025600
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.42351325
43mitochondrial respiratory chain complex I assembly (GO:0032981)3.42351325
44NADH dehydrogenase complex assembly (GO:0010257)3.42351325
45regulation of cellular amino acid metabolic process (GO:0006521)3.42052806
46DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.39630640
47nuclear-transcribed mRNA catabolic process (GO:0000956)3.37646619
48electron transport chain (GO:0022900)3.37504487
49C-terminal protein lipidation (GO:0006501)3.37227276
50negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36844296
51negative regulation of ligase activity (GO:0051352)3.36844296
52telomere maintenance via recombination (GO:0000722)3.34817199
53GTP biosynthetic process (GO:0006183)3.33679627
54regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.31855921
55regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.31526957
56intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.29859828
57signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.29859828
58protein complex biogenesis (GO:0070271)3.29076311
59signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28905450
60signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28905450
61signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28905450
62cellular component biogenesis (GO:0044085)3.24890287
63mRNA catabolic process (GO:0006402)3.24030928
64purine nucleobase biosynthetic process (GO:0009113)3.21983620
65DNA ligation (GO:0006266)3.20426901
66peptidyl-histidine modification (GO:0018202)3.18406007
67signal transduction involved in DNA damage checkpoint (GO:0072422)3.15213479
68signal transduction involved in DNA integrity checkpoint (GO:0072401)3.15213479
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.13240307
70signal peptide processing (GO:0006465)3.12232084
71exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11226334
72establishment of protein localization to mitochondrial membrane (GO:0090151)3.10604791
73Arp2/3 complex-mediated actin nucleation (GO:0034314)3.09730059
74signal transduction involved in cell cycle checkpoint (GO:0072395)3.09231919
75anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05880268
76iron-sulfur cluster assembly (GO:0016226)3.03466667
77metallo-sulfur cluster assembly (GO:0031163)3.03466667
78DNA strand elongation involved in DNA replication (GO:0006271)3.03426959
79nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.01519471
80chaperone-mediated protein transport (GO:0072321)3.00864715
81rRNA processing (GO:0006364)3.00819226
82cytochrome complex assembly (GO:0017004)3.00737912
83mitochondrial respiratory chain complex assembly (GO:0033108)3.00552634
84antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.00243733
85GDP-mannose metabolic process (GO:0019673)2.98586487
86RNA catabolic process (GO:0006401)2.98357724
87C-terminal protein amino acid modification (GO:0018410)2.97033372
88oxidative phosphorylation (GO:0006119)2.96318069
89pyrimidine nucleotide catabolic process (GO:0006244)2.95876450
90positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95036047
91DNA damage response, detection of DNA damage (GO:0042769)2.94329266
92mitotic recombination (GO:0006312)2.93125336
93CENP-A containing nucleosome assembly (GO:0034080)2.92259636
94rRNA metabolic process (GO:0016072)2.91886625
95nucleobase biosynthetic process (GO:0046112)2.90284625
962-deoxyribonucleotide metabolic process (GO:0009394)2.88756064
97DNA strand elongation (GO:0022616)2.88090864
98sequestering of actin monomers (GO:0042989)2.87967373
99adenosine metabolic process (GO:0046085)2.87725824
100pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.86692888
101telomere maintenance via telomere lengthening (GO:0010833)2.86496270
102purine nucleotide salvage (GO:0032261)2.86227793
103nucleotide-excision repair, DNA gap filling (GO:0006297)2.85788757
104pseudouridine synthesis (GO:0001522)2.85390618
105deoxyribose phosphate metabolic process (GO:0019692)2.84520954
106pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.84009769
107protein deneddylation (GO:0000338)2.82577315
108preassembly of GPI anchor in ER membrane (GO:0016254)2.82372200
109positive regulation of ligase activity (GO:0051351)2.82174827
110transcription-coupled nucleotide-excision repair (GO:0006283)2.81845608
111L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.80931123
112CTP biosynthetic process (GO:0006241)2.80477335
113CTP metabolic process (GO:0046036)2.80477335
114chromatin remodeling at centromere (GO:0031055)2.79396212
1157-methylguanosine mRNA capping (GO:0006370)2.78623613
116tRNA methylation (GO:0030488)2.78408686
117rRNA modification (GO:0000154)2.77024518
118RNA capping (GO:0036260)2.76225730
1197-methylguanosine RNA capping (GO:0009452)2.76225730
120negative regulation of execution phase of apoptosis (GO:1900118)2.76023040
121mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.75553913
122UTP biosynthetic process (GO:0006228)2.74756763
123spliceosomal snRNP assembly (GO:0000387)2.73787866
124regulation of mitochondrial translation (GO:0070129)2.72673334
125deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.71215664
1262-deoxyribonucleotide biosynthetic process (GO:0009265)2.71005391
127deoxyribose phosphate biosynthetic process (GO:0046385)2.71005391
128histone mRNA metabolic process (GO:0008334)2.70913682
129pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.69501664
130mismatch repair (GO:0006298)2.69049020
131mannosylation (GO:0097502)2.67754589
132positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.66541110
133reciprocal DNA recombination (GO:0035825)2.65569220
134reciprocal meiotic recombination (GO:0007131)2.65569220
135spliceosomal complex assembly (GO:0000245)2.65386029
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65242863
137tRNA modification (GO:0006400)2.65220706
138nucleoside salvage (GO:0043174)2.64035682
139viral mRNA export from host cell nucleus (GO:0046784)2.63927469
140positive regulation of cell cycle arrest (GO:0071158)2.63571323
141DNA catabolic process, exonucleolytic (GO:0000738)2.63094753
142termination of RNA polymerase I transcription (GO:0006363)2.61791299
143guanosine-containing compound biosynthetic process (GO:1901070)2.61367416
144lymphoid progenitor cell differentiation (GO:0002320)2.61225159
145DNA-templated transcription, termination (GO:0006353)2.60112917
146platelet dense granule organization (GO:0060155)2.59674302
147actin nucleation (GO:0045010)2.59582527
148tRNA processing (GO:0008033)2.59276888
149protein targeting to mitochondrion (GO:0006626)2.58004856
150DNA replication checkpoint (GO:0000076)2.57735411
151deoxyribonucleotide catabolic process (GO:0009264)2.54567213
152GPI anchor biosynthetic process (GO:0006506)2.52906166
153DNA replication initiation (GO:0006270)2.49702948
154interferon-gamma production (GO:0032609)2.49360313
155cullin deneddylation (GO:0010388)2.48664777
156maturation of 5.8S rRNA (GO:0000460)2.48104458
157rRNA methylation (GO:0031167)2.48038144
158ncRNA processing (GO:0034470)2.47746077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.93115867
2E2F7_22180533_ChIP-Seq_HELA_Human4.74058832
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.25695869
4ELF1_17652178_ChIP-ChIP_JURKAT_Human3.84280115
5CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.74323266
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.70876868
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.42082900
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.27948290
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.19611393
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.03344261
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.87414963
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85045240
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.77390841
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.76421610
15VDR_23849224_ChIP-Seq_CD4+_Human2.67376903
16SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.51389021
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45239953
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.45193529
19IRF8_22096565_ChIP-ChIP_GC-B_Human2.42462053
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.41081657
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33667414
22FOXP3_21729870_ChIP-Seq_TREG_Human2.30031544
23NOTCH1_21737748_ChIP-Seq_TLL_Human2.25019473
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.24583979
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.23916653
26FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.22103085
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16797706
28FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.15662298
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11374772
30SRF_21415370_ChIP-Seq_HL-1_Mouse2.11190267
31DCP1A_22483619_ChIP-Seq_HELA_Human2.06496455
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.05567487
33ELK1_19687146_ChIP-ChIP_HELA_Human2.01878293
34HOXB4_20404135_ChIP-ChIP_EML_Mouse2.01860254
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.01503624
36XRN2_22483619_ChIP-Seq_HELA_Human1.98302195
37TTF2_22483619_ChIP-Seq_HELA_Human1.97602844
38ERG_20887958_ChIP-Seq_HPC-7_Mouse1.96613839
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.95251835
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94912728
41E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94889888
42BP1_19119308_ChIP-ChIP_Hs578T_Human1.94702785
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87120146
44E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82372850
45CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.81412652
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.70205818
47MYC_18940864_ChIP-ChIP_HL60_Human1.68876926
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.60070123
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.55338823
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.54652920
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52219608
52NELFA_20434984_ChIP-Seq_ESCs_Mouse1.51989211
53GABP_19822575_ChIP-Seq_HepG2_Human1.51850274
54TFEB_21752829_ChIP-Seq_HELA_Human1.48295006
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44536205
56* SPI1_23547873_ChIP-Seq_NB4_Human1.44118439
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.43285693
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.41649440
59KDM5A_27292631_Chip-Seq_BREAST_Human1.40753682
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33205096
61MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32967195
62MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.31097084
63IRF1_19129219_ChIP-ChIP_H3396_Human1.30277269
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27462261
65YY1_21170310_ChIP-Seq_MESCs_Mouse1.23231515
66FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22722113
67SCL_19346495_ChIP-Seq_HPC-7_Human1.21844508
68GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.19503543
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.18881938
70EGR1_23403033_ChIP-Seq_LIVER_Mouse1.16949889
71YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16043597
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15728235
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14692446
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.14410700
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.13165453
76CIITA_25753668_ChIP-Seq_RAJI_Human1.12240095
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11528816
78RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.08559127
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.07874155
80BCL6_27268052_Chip-Seq_Bcells_Human1.05248850
81IRF8_21731497_ChIP-ChIP_J774_Mouse1.04431724
82RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.03158876
83CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01302410
84MYB_26560356_Chip-Seq_TH2_Human1.01122127
85TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.98064322
86TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97802601
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96690310
88FOXP1_21924763_ChIP-Seq_HESCs_Human0.94655844
89CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.94230194
90VDR_21846776_ChIP-Seq_THP-1_Human0.94080211
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93716967
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.91433497
93CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91228053
94STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.88801916
95ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88625343
96MYB_26560356_Chip-Seq_TH1_Human0.88209434
97MYCN_18555785_ChIP-Seq_MESCs_Mouse0.88095066
98GATA3_26560356_Chip-Seq_TH2_Human0.84645095
99ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84443104
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.84422919
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.82838255
102AR_20517297_ChIP-Seq_VCAP_Human0.82721749
103SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.82040712
104FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81856107
105MAF_26560356_Chip-Seq_TH2_Human0.81327670
106NFE2_27457419_Chip-Seq_LIVER_Mouse0.81246305
107CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.81125232
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.79989823
109POU5F1_16153702_ChIP-ChIP_HESCs_Human0.77413040
110GATA2_22383799_ChIP-Seq_G1ME_Mouse0.75546324
111EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.74985842
112POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.74853368
113STAT1_20625510_ChIP-Seq_HELA_Human0.74027673
114EWS_26573619_Chip-Seq_HEK293_Human0.72293184
115PADI4_21655091_ChIP-ChIP_MCF-7_Human0.72181364
116PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71510487
117FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.71362022
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.71220676

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation4.57073577
2MP0003806_abnormal_nucleotide_metabolis4.00058270
3MP0003136_yellow_coat_color3.11139512
4MP0004381_abnormal_hair_follicle3.08625888
5MP0003763_abnormal_thymus_physiology2.85670864
6MP0005671_abnormal_response_to2.80632442
7MP0003724_increased_susceptibility_to2.67075140
8MP0006292_abnormal_olfactory_placode2.64902848
9MP0005075_abnormal_melanosome_morpholog2.64202809
10MP0001188_hyperpigmentation2.46089167
11MP0008058_abnormal_DNA_repair2.38020378
12MP0003693_abnormal_embryo_hatching2.30517944
13MP0002396_abnormal_hematopoietic_system2.23938896
14MP0000372_irregular_coat_pigmentation2.22247396
15MP0001835_abnormal_antigen_presentation2.13471803
16MP0005409_darkened_coat_color2.11557634
17MP0008875_abnormal_xenobiotic_pharmacok2.08658604
18MP0002132_abnormal_respiratory_system2.07169486
19MP0009785_altered_susceptibility_to2.06653740
20MP0002095_abnormal_skin_pigmentation1.91576307
21MP0009333_abnormal_splenocyte_physiolog1.90874448
22MP0005174_abnormal_tail_pigmentation1.82080486
23MP0002148_abnormal_hypersensitivity_rea1.81745712
24MP0001764_abnormal_homeostasis1.78399598
25MP0001986_abnormal_taste_sensitivity1.77435964
26MP0006035_abnormal_mitochondrial_morpho1.72996616
27MP0002277_abnormal_respiratory_mucosa1.72566848
28MP0005000_abnormal_immune_tolerance1.70701999
29MP0001800_abnormal_humoral_immune1.69965863
30MP0010094_abnormal_chromosome_stability1.68720330
31MP0000685_abnormal_immune_system1.67220850
32MP0002420_abnormal_adaptive_immunity1.64791449
33MP0009764_decreased_sensitivity_to1.61514236
34MP0001819_abnormal_immune_cell1.61356990
35MP0002723_abnormal_immune_serum1.59646182
36MP0000015_abnormal_ear_pigmentation1.57568891
37MP0002452_abnormal_antigen_presenting1.56045389
38MP0002398_abnormal_bone_marrow1.55363664
39MP0008007_abnormal_cellular_replicative1.54876498
40MP0000490_abnormal_crypts_of1.54674999
41MP0000465_gastrointestinal_hemorrhage1.52977748
42MP0001790_abnormal_immune_system1.52205192
43MP0005387_immune_system_phenotype1.52205192
44MP0002009_preneoplasia1.50970839
45MP0005025_abnormal_response_to1.50604733
46MP0003077_abnormal_cell_cycle1.47447857
47MP0008932_abnormal_embryonic_tissue1.46306767
48MP0004957_abnormal_blastocyst_morpholog1.44231505
49MP0000716_abnormal_immune_system1.41399808
50MP0002102_abnormal_ear_morphology1.41377323
51MP0003786_premature_aging1.41123255
52MP0000689_abnormal_spleen_morphology1.40311338
53MP0000358_abnormal_cell_content/1.37733558
54MP0002837_dystrophic_cardiac_calcinosis1.37624972
55MP0002938_white_spotting1.36936122
56MP0005360_urolithiasis1.36417585
57MP0008789_abnormal_olfactory_epithelium1.36214826
58MP0002405_respiratory_system_inflammati1.35814243
59MP0008469_abnormal_protein_level1.34590782
60MP0008057_abnormal_DNA_replication1.34471046
61MP0000703_abnormal_thymus_morphology1.34046872
62MP0002722_abnormal_immune_system1.30930626
63MP0002166_altered_tumor_susceptibility1.29430342
64MP0001529_abnormal_vocalization1.29278747
65MP0002933_joint_inflammation1.28532271
66MP0002429_abnormal_blood_cell1.22745992
67MP0003866_abnormal_defecation1.21757878
68MP0005085_abnormal_gallbladder_physiolo1.19823782
69MP0003111_abnormal_nucleus_morphology1.18479101
70MP0005084_abnormal_gallbladder_morpholo1.17688336
71MP0002638_abnormal_pupillary_reflex1.17537215
72MP0002419_abnormal_innate_immunity1.16383495
73MP0005332_abnormal_amino_acid1.15420375
74MP0002876_abnormal_thyroid_physiology1.13425684
75MP0001919_abnormal_reproductive_system1.08840154
76MP0006082_CNS_inflammation1.08142465
77MP0005083_abnormal_biliary_tract1.08123427
78MP0005646_abnormal_pituitary_gland1.07280317
79MP0004147_increased_porphyrin_level1.07030448
80MP0000613_abnormal_salivary_gland1.06106122
81MP0001853_heart_inflammation1.05361301
82MP0005171_absent_coat_pigmentation1.04857403
83MP0005379_endocrine/exocrine_gland_phen1.04161906
84MP0006054_spinal_hemorrhage1.04110018
85MP0005365_abnormal_bile_salt1.03913607
86MP0003718_maternal_effect1.03614725
87MP0003436_decreased_susceptibility_to1.01055733
88MP0002163_abnormal_gland_morphology1.00911504
89MP0000566_synostosis1.00725168
90MP0000049_abnormal_middle_ear0.99721403
91MP0002006_tumorigenesis0.99456580
92MP0008877_abnormal_DNA_methylation0.97957537
93MP0001873_stomach_inflammation0.96789195
94MP0008873_increased_physiological_sensi0.94966095
95MP0009643_abnormal_urine_homeostasis0.94163709
96MP0003011_delayed_dark_adaptation0.94128102
97MP0005464_abnormal_platelet_physiology0.92084233
98MP0010155_abnormal_intestine_physiology0.90753119
99MP0005636_abnormal_mineral_homeostasis0.90265984
100MP0003195_calcinosis0.90218422
101MP0005645_abnormal_hypothalamus_physiol0.89714991
102MP0005584_abnormal_enzyme/coenzyme_acti0.88835642
103MP0002177_abnormal_outer_ear0.88822746
104MP0005253_abnormal_eye_physiology0.87602124
105MP0009697_abnormal_copulation0.87270525
106MP0005408_hypopigmentation0.86186990
107MP0005319_abnormal_enzyme/_coenzyme0.85766181
108MP0002019_abnormal_tumor_incidence0.83973755
109MP0001661_extended_life_span0.83407425
110MP0008872_abnormal_physiological_respon0.82471343
111MP0000858_altered_metastatic_potential0.82269384
112MP0005389_reproductive_system_phenotype0.82130414
113MP0003315_abnormal_perineum_morphology0.81970808
114MP0002210_abnormal_sex_determination0.81794095
115MP0001324_abnormal_eye_pigmentation0.81577801
116MP0001186_pigmentation_phenotype0.80920971
117MP0002751_abnormal_autonomic_nervous0.80235170
118MP0006036_abnormal_mitochondrial_physio0.79314250
119MP0005410_abnormal_fertilization0.78159162
120MP0001845_abnormal_inflammatory_respons0.76198577
121MP0002160_abnormal_reproductive_system0.75631025
122MP0003186_abnormal_redox_activity0.75545149
123MP0000681_abnormal_thyroid_gland0.74617138
124MP0004142_abnormal_muscle_tone0.73969887
125MP0005499_abnormal_olfactory_system0.73340926
126MP0005394_taste/olfaction_phenotype0.73340926
127MP0008004_abnormal_stomach_pH0.72926955
128MP0001905_abnormal_dopamine_level0.70051912
129MP0004808_abnormal_hematopoietic_stem0.69633138
130MP0006072_abnormal_retinal_apoptosis0.69310971
131MP0001984_abnormal_olfaction0.66521450
132MP0000313_abnormal_cell_death0.66424031

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)4.53397300
2Abnormal number of erythroid precursors (HP:0012131)4.40104178
3Abnormality of cells of the erythroid lineage (HP:0012130)4.37181065
4Hepatocellular necrosis (HP:0001404)3.64781345
5Macrocytic anemia (HP:0001972)3.51677011
6Mitochondrial inheritance (HP:0001427)3.45857096
7Aplasia/Hypoplasia of the sacrum (HP:0008517)3.40731967
8Increased muscle lipid content (HP:0009058)3.38723648
9Type I transferrin isoform profile (HP:0003642)3.38145984
103-Methylglutaconic aciduria (HP:0003535)3.33273961
11Acute necrotizing encephalopathy (HP:0006965)3.28765702
12Cerebral edema (HP:0002181)3.27170350
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21044243
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21044243
15Hepatic necrosis (HP:0002605)3.14191631
16Aplastic anemia (HP:0001915)3.13715704
17Pallor (HP:0000980)3.12098511
18Increased CSF lactate (HP:0002490)3.08417496
19Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.01180018
20Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.97847202
21Abnormal mitochondria in muscle tissue (HP:0008316)2.95134291
22Microvesicular hepatic steatosis (HP:0001414)2.94949317
23Increased hepatocellular lipid droplets (HP:0006565)2.94498086
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.84093147
25Hypothermia (HP:0002045)2.71479250
26Renal Fanconi syndrome (HP:0001994)2.70525158
27Progressive macrocephaly (HP:0004481)2.66485168
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.65232142
29Decreased electroretinogram (ERG) amplitude (HP:0000654)2.64905759
30Abnormal hemoglobin (HP:0011902)2.63474196
31Elevated erythrocyte sedimentation rate (HP:0003565)2.52462507
32Reduced antithrombin III activity (HP:0001976)2.52174809
33Lipid accumulation in hepatocytes (HP:0006561)2.51145308
34Increased serum lactate (HP:0002151)2.49453247
35Lethargy (HP:0001254)2.49247547
36Increased IgM level (HP:0003496)2.45434052
37Acute encephalopathy (HP:0006846)2.41944783
38Exertional dyspnea (HP:0002875)2.40406912
39T lymphocytopenia (HP:0005403)2.39370823
40IgM deficiency (HP:0002850)2.33207089
41Abnormality of B cell number (HP:0010975)2.33090607
42B lymphocytopenia (HP:0010976)2.33090607
43True hermaphroditism (HP:0010459)2.32433632
44Abnormal protein glycosylation (HP:0012346)2.32121047
45Abnormal glycosylation (HP:0012345)2.32121047
46Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.32121047
47Abnormal protein N-linked glycosylation (HP:0012347)2.32121047
48Neutropenia (HP:0001875)2.27764355
49Optic disc pallor (HP:0000543)2.26963973
50Progressive microcephaly (HP:0000253)2.26237118
51IgG deficiency (HP:0004315)2.26070242
52Abnormality of T cell number (HP:0011839)2.25953250
53Opisthotonus (HP:0002179)2.25807853
54CNS demyelination (HP:0007305)2.20704007
55Thrombocytosis (HP:0001894)2.17958969
5611 pairs of ribs (HP:0000878)2.17332982
57Exercise intolerance (HP:0003546)2.16277031
58Dry hair (HP:0011359)2.13315992
59Meningitis (HP:0001287)2.12994227
60Respiratory difficulties (HP:0002880)2.12592442
61Type 2 muscle fiber atrophy (HP:0003554)2.12317903
62Leukodystrophy (HP:0002415)2.12215335
63Chronic obstructive pulmonary disease (HP:0006510)2.11936772
64Obstructive lung disease (HP:0006536)2.11936772
65Patchy hypopigmentation of hair (HP:0011365)2.11670877
66Molar tooth sign on MRI (HP:0002419)2.09870620
67Abnormality of midbrain morphology (HP:0002418)2.09870620
68Methylmalonic aciduria (HP:0012120)2.08911936
69Panhypogammaglobulinemia (HP:0003139)2.08566322
70Testicular atrophy (HP:0000029)2.08551262
71Petechiae (HP:0000967)2.08461810
72Abnormality of the axillary hair (HP:0100134)2.08178529
73Abnormality of secondary sexual hair (HP:0009888)2.08178529
74Poikiloderma (HP:0001029)2.07966837
75Severe combined immunodeficiency (HP:0004430)2.06410269
76Oral leukoplakia (HP:0002745)2.05452711
77Pulmonary fibrosis (HP:0002206)2.05041225
78Pancytopenia (HP:0001876)2.04593084
79Muscle fiber atrophy (HP:0100295)2.03391681
80Abnormality of the columella (HP:0009929)2.00522868
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.00122132
82Lactic acidosis (HP:0003128)1.99163483
83Prolonged neonatal jaundice (HP:0006579)1.99071055
84Increased intramyocellular lipid droplets (HP:0012240)1.98964607
85Recurrent abscess formation (HP:0002722)1.98422518
86Abnormality of serum amino acid levels (HP:0003112)1.98173197
87Abnormal rod and cone electroretinograms (HP:0008323)1.97834467
88Aplasia/hypoplasia of the uterus (HP:0008684)1.97488052
89Abnormality of T cells (HP:0002843)1.97090663
90Agammaglobulinemia (HP:0004432)1.96963932
91Abnormality of renal resorption (HP:0011038)1.96855655
92Respiratory failure (HP:0002878)1.95338117
93Absent thumb (HP:0009777)1.94661945
94Recurrent bronchitis (HP:0002837)1.94639945
95Chromsome breakage (HP:0040012)1.94162248
96White forelock (HP:0002211)1.92666289
97Attenuation of retinal blood vessels (HP:0007843)1.92569847
98Ragged-red muscle fibers (HP:0003200)1.92308727
99Triphalangeal thumb (HP:0001199)1.92301254
100Abnormality of the preputium (HP:0100587)1.90821446
101Pancreatic fibrosis (HP:0100732)1.90051106
102Emotional lability (HP:0000712)1.89940968
103Prolonged bleeding time (HP:0003010)1.89414690
104Chronic otitis media (HP:0000389)1.88239857
105Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87761194
106Dicarboxylic aciduria (HP:0003215)1.87761194
107Myositis (HP:0100614)1.87640625
108Autoimmune hemolytic anemia (HP:0001890)1.87566821
109Thyroid-stimulating hormone excess (HP:0002925)1.87023813
110Lymphoma (HP:0002665)1.86837803
111Congenital stationary night blindness (HP:0007642)1.86030196
112Abnormality of aromatic amino acid family metabolism (HP:0004338)1.85868271
113Congenital, generalized hypertrichosis (HP:0004540)1.84467764
114Encephalitis (HP:0002383)1.84261388
115Stomatitis (HP:0010280)1.84005679
116Squamous cell carcinoma (HP:0002860)1.83373727
117Asplenia (HP:0001746)1.82526340
118Cleft eyelid (HP:0000625)1.81386593
119Methylmalonic acidemia (HP:0002912)1.80656222
120Dyschromatopsia (HP:0007641)1.80506737
121Hypoplasia of the pons (HP:0012110)1.80108175
122Abnormality of alanine metabolism (HP:0010916)1.79208588
123Hyperalaninemia (HP:0003348)1.79208588
124Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79208588
125Pancreatic cysts (HP:0001737)1.79107845
126Median cleft lip (HP:0000161)1.79000612
127Microretrognathia (HP:0000308)1.78734661
128Renal cortical cysts (HP:0000803)1.78391677
129Granulocytopenia (HP:0001913)1.78150772
130Hyperglycinemia (HP:0002154)1.77384358
131Abnormality of the prostate (HP:0008775)1.76634528
132Premature graying of hair (HP:0002216)1.75956542
133Chromosomal breakage induced by crosslinking agents (HP:0003221)1.75952198
134Acute hepatic failure (HP:0006554)1.73985836
135Combined immunodeficiency (HP:0005387)1.73623103
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.73066268
137Entropion (HP:0000621)1.70669009
138Vomiting (HP:0002013)1.70146678
139Facial diplegia (HP:0001349)1.69719018
140Medial flaring of the eyebrow (HP:0010747)1.69015356
141Metaphyseal dysplasia (HP:0100255)1.66587766
142Multiple enchondromatosis (HP:0005701)1.66583675
143Generalized aminoaciduria (HP:0002909)1.65963725
144Abnormality of eosinophils (HP:0001879)1.64451651
145Abnormality of aspartate family amino acid metabolism (HP:0010899)1.64068424

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TLK14.06196529
2STK163.56506731
3NME23.07552585
4BCKDK3.06710013
5VRK22.97637188
6IRAK42.52857146
7CASK2.25348066
8EIF2AK12.24808134
9IRAK32.21239196
10TXK2.20711642
11MKNK22.17678626
12TNIK2.16484614
13SRPK12.10283496
14SCYL22.09599636
15TESK12.05567915
16IRAK12.04547296
17PBK2.04164735
18VRK11.96313383
19TEC1.92763518
20BUB11.87299363
21CDK191.85730275
22DYRK31.84508765
23NLK1.83962529
24IRAK21.75561334
25MAP4K21.73353883
26WEE11.64244117
27MKNK11.60312527
28CLK11.59781024
29PDK21.55709805
30EIF2AK31.54403401
31CDK81.51872164
32BLK1.50898256
33MST41.48636966
34LIMK11.42994412
35BMPR1B1.40733638
36TRIM281.40396784
37PIM21.35145138
38NME11.31700782
39MAP4K11.28043712
40KIT1.27537178
41ZAK1.24898739
42ARAF1.22258190
43ACVR1B1.21156687
44MAP3K141.17279470
45YES11.16925193
46CAMKK21.12735368
47BTK1.11205127
48ERN11.08824810
49EIF2AK21.06344289
50CSNK1G21.06276129
51CDK31.05771983
52RPS6KA41.05579819
53GRK61.04700633
54IKBKE1.02146358
55ADRBK21.01922855
56MUSK0.99554476
57MAPKAPK50.93811168
58PLK40.92127515
59MAP2K70.86965583
60NEK90.85048799
61ZAP700.84219596
62ITK0.83882144
63MAPK150.83874912
64ERBB30.82858829
65RPS6KA50.81314316
66PRKCQ0.81078008
67TESK20.80787532
68TNK20.79022411
69DAPK10.77502395
70BMPR20.76582572
71TGFBR10.74948080
72DYRK20.72445274
73LCK0.72353118
74KDR0.72122065
75CDK70.69723953
76IKBKB0.69255860
77NUAK10.68730567
78WNK40.65821334
79GRK70.64808583
80ABL20.64642763
81MYLK0.64240059
82LYN0.63084619
83FRK0.62919281
84BRSK20.62718214
85SYK0.61128498
86NEK10.60237012
87CSNK1G30.60130812
88GRK10.59204030
89TIE10.57812539
90FES0.57475250
91FLT30.56860302
92TYK20.56844006
93PIM10.56211754
94BRAF0.56121892
95CDK90.55737960
96CSNK1A1L0.55299292
97CSNK2A10.55227062
98PIK3CA0.54939491
99MAPK130.54758482
100MAP3K50.54377950
101AURKA0.53576068
102ATR0.53360095
103CSNK1G10.53180666
104AURKB0.52650320
105PLK10.51210235
106TAOK30.51100315
107SIK30.50939720
108MAP3K130.48979511
109PRKD20.48583319
110DAPK30.48296994
111NEK60.46645367
112TBK10.46496706
113JAK30.46170761
114CSK0.45784871
115PINK10.45533514
116RPS6KB20.45232340
117MARK30.45008069
118PAK10.44943684
119CDK60.44367508
120STK40.43437910
121MAP3K110.43318434
122CDK40.43184409
123BCR0.42860742
124MAPKAPK30.42709322
125TRPM70.41945910
126ILK0.41684129
127CDC70.40618225
128CSNK2A20.40162395
129STK100.39344943
130CHEK20.38286847
131OBSCN0.38218270
132ADRBK10.38190490
133TSSK60.38103887
134MAP2K60.37294158
135CSF1R0.36864542
136MAP3K120.36863841
137DYRK1B0.36619777
138CCNB10.36089134
139MATK0.29980970

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.49889134
2DNA replication_Homo sapiens_hsa030303.54122406
3Protein export_Homo sapiens_hsa030603.32070112
4RNA polymerase_Homo sapiens_hsa030203.07574526
5Mismatch repair_Homo sapiens_hsa034302.88791296
6Homologous recombination_Homo sapiens_hsa034402.76872029
7Spliceosome_Homo sapiens_hsa030402.68222867
8Proteasome_Homo sapiens_hsa030502.59111300
9Oxidative phosphorylation_Homo sapiens_hsa001902.38029768
10Base excision repair_Homo sapiens_hsa034102.31932941
11Pyrimidine metabolism_Homo sapiens_hsa002402.26201995
12Primary immunodeficiency_Homo sapiens_hsa053402.24146583
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.19849523
14Nucleotide excision repair_Homo sapiens_hsa034202.19475804
15Parkinsons disease_Homo sapiens_hsa050122.11667748
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.04943115
17Basal transcription factors_Homo sapiens_hsa030221.90282779
18Fanconi anemia pathway_Homo sapiens_hsa034601.81978791
19Huntingtons disease_Homo sapiens_hsa050161.67014055
20Non-homologous end-joining_Homo sapiens_hsa034501.65772541
21Type I diabetes mellitus_Homo sapiens_hsa049401.63762801
22Regulation of autophagy_Homo sapiens_hsa041401.60088538
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.56579116
24RNA degradation_Homo sapiens_hsa030181.52248860
25Alzheimers disease_Homo sapiens_hsa050101.44746852
26Purine metabolism_Homo sapiens_hsa002301.38598852
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.37822541
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31704583
29Herpes simplex infection_Homo sapiens_hsa051681.25409754
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.22024331
31Hematopoietic cell lineage_Homo sapiens_hsa046401.17191558
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16372164
33Graft-versus-host disease_Homo sapiens_hsa053321.15764593
34RNA transport_Homo sapiens_hsa030131.14806290
35Antigen processing and presentation_Homo sapiens_hsa046121.12162870
36Allograft rejection_Homo sapiens_hsa053301.09367070
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.07574762
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.07567875
39Propanoate metabolism_Homo sapiens_hsa006401.07164473
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02977789
41One carbon pool by folate_Homo sapiens_hsa006701.01888538
42Cell cycle_Homo sapiens_hsa041101.01000400
43Sulfur relay system_Homo sapiens_hsa041221.00670907
44Measles_Homo sapiens_hsa051621.00158038
45Peroxisome_Homo sapiens_hsa041460.99570819
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.99160499
47Systemic lupus erythematosus_Homo sapiens_hsa053220.99133041
48NF-kappa B signaling pathway_Homo sapiens_hsa040640.98613042
49Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94169109
50Folate biosynthesis_Homo sapiens_hsa007900.92975035
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92219044
52Pyruvate metabolism_Homo sapiens_hsa006200.91414049
53Arachidonic acid metabolism_Homo sapiens_hsa005900.88359113
54Autoimmune thyroid disease_Homo sapiens_hsa053200.87394394
55Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.87308259
56Cysteine and methionine metabolism_Homo sapiens_hsa002700.86503084
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.85821676
58Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85185256
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84339756
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82734702
61Epstein-Barr virus infection_Homo sapiens_hsa051690.79462811
62Sulfur metabolism_Homo sapiens_hsa009200.79121164
63Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.74850390
64p53 signaling pathway_Homo sapiens_hsa041150.74295316
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71638093
66Phototransduction_Homo sapiens_hsa047440.70783371
67mRNA surveillance pathway_Homo sapiens_hsa030150.69922734
68Collecting duct acid secretion_Homo sapiens_hsa049660.68238226
69Staphylococcus aureus infection_Homo sapiens_hsa051500.67897774
70Sphingolipid metabolism_Homo sapiens_hsa006000.67759585
71Fatty acid elongation_Homo sapiens_hsa000620.67651120
72Primary bile acid biosynthesis_Homo sapiens_hsa001200.67030172
73Asthma_Homo sapiens_hsa053100.65953352
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65182662
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.65083824
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.64207479
77T cell receptor signaling pathway_Homo sapiens_hsa046600.63950964
78Other glycan degradation_Homo sapiens_hsa005110.63784980
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63655592
80Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60854745
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59890916
82Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57560503
83Caffeine metabolism_Homo sapiens_hsa002320.53938467
84Viral myocarditis_Homo sapiens_hsa054160.53802395
85Selenocompound metabolism_Homo sapiens_hsa004500.52666343
86Biosynthesis of amino acids_Homo sapiens_hsa012300.49132396
87Tryptophan metabolism_Homo sapiens_hsa003800.46702673
88Chemical carcinogenesis_Homo sapiens_hsa052040.46350277
89Metabolic pathways_Homo sapiens_hsa011000.46158082
90Fatty acid degradation_Homo sapiens_hsa000710.43768095
91Ether lipid metabolism_Homo sapiens_hsa005650.43055467
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.41655991
93Glutathione metabolism_Homo sapiens_hsa004800.41302763
94Carbon metabolism_Homo sapiens_hsa012000.41169466
95Malaria_Homo sapiens_hsa051440.41080513
96Butanoate metabolism_Homo sapiens_hsa006500.40857179
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.40118838
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39924457
99B cell receptor signaling pathway_Homo sapiens_hsa046620.39332729
100Linoleic acid metabolism_Homo sapiens_hsa005910.39218622
101Fructose and mannose metabolism_Homo sapiens_hsa000510.39202687
102Alcoholism_Homo sapiens_hsa050340.38712161
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37969378
104Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37361471
105Maturity onset diabetes of the young_Homo sapiens_hsa049500.37331796
106Leishmaniasis_Homo sapiens_hsa051400.37105112
107Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35861552
108Fatty acid metabolism_Homo sapiens_hsa012120.35656764
109Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.33948272
110Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33109239
111Notch signaling pathway_Homo sapiens_hsa043300.32729360
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.32493806
113Drug metabolism - other enzymes_Homo sapiens_hsa009830.32236763
114Hepatitis B_Homo sapiens_hsa051610.31583157
115Lysosome_Homo sapiens_hsa041420.31449424
116Salmonella infection_Homo sapiens_hsa051320.31335459
117Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31236322
118HTLV-I infection_Homo sapiens_hsa051660.31202872
119Rheumatoid arthritis_Homo sapiens_hsa053230.30956071
120Legionellosis_Homo sapiens_hsa051340.29545854
121Influenza A_Homo sapiens_hsa051640.28714331
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28427683
123Acute myeloid leukemia_Homo sapiens_hsa052210.26877059
124Shigellosis_Homo sapiens_hsa051310.26675767
125Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.26181172
126N-Glycan biosynthesis_Homo sapiens_hsa005100.25736852
127Apoptosis_Homo sapiens_hsa042100.24115446
128Pertussis_Homo sapiens_hsa051330.23769284
129Cardiac muscle contraction_Homo sapiens_hsa042600.23296134
130Viral carcinogenesis_Homo sapiens_hsa052030.21919879
131Retinol metabolism_Homo sapiens_hsa008300.19983182
132Steroid hormone biosynthesis_Homo sapiens_hsa001400.19396359
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.19177067
134Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.18684987

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