METTL24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of metalloenzyme activity (GO:0048552)7.79858387
2negative regulation of nitric-oxide synthase activity (GO:0051001)7.02668908
3negative regulation of nitric oxide biosynthetic process (GO:0045019)6.76956520
4membrane raft organization (GO:0031579)6.08124966
5regulation of helicase activity (GO:0051095)6.05240009
6blood vessel maturation (GO:0001955)5.73653645
7membrane assembly (GO:0071709)5.61638278
8negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)5.06761932
9negative regulation of T-helper cell differentiation (GO:0045623)5.06761932
10negative regulation of monooxygenase activity (GO:0032769)4.95295641
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.73235891
12ovulation from ovarian follicle (GO:0001542)4.67388573
13negative regulation of alpha-beta T cell differentiation (GO:0046639)4.59164441
14fatty acid homeostasis (GO:0055089)4.47755670
15cAMP biosynthetic process (GO:0006171)4.32633317
16positive regulation of vasculogenesis (GO:2001214)4.32133717
17negative regulation of endothelial cell proliferation (GO:0001937)4.30143415
18regulation of hexokinase activity (GO:1903299)4.27945587
19regulation of glucokinase activity (GO:0033131)4.27945587
20endothelium development (GO:0003158)4.24209723
21lactate metabolic process (GO:0006089)4.22333585
22substrate-dependent cell migration (GO:0006929)4.16439280
23inositol phosphate dephosphorylation (GO:0046855)4.09829642
24phosphorylated carbohydrate dephosphorylation (GO:0046838)4.09829642
25regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)4.05317746
26inositol phosphate catabolic process (GO:0071545)4.05245117
27lymph vessel development (GO:0001945)4.03405657
28relaxation of smooth muscle (GO:0044557)3.94135083
29prenylation (GO:0097354)3.93076091
30protein prenylation (GO:0018342)3.93076091
31regulation of vasculogenesis (GO:2001212)3.88924901
32vasculogenesis (GO:0001570)3.73822663
33negative regulation of anoikis (GO:2000811)3.72276948
34regulation of memory T cell differentiation (GO:0043380)3.71750927
35negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.66345333
36nitric oxide mediated signal transduction (GO:0007263)3.64816289
37retina vasculature morphogenesis in camera-type eye (GO:0061299)3.62502601
38regulation of tight junction assembly (GO:2000810)3.52996598
39negative regulation of JAK-STAT cascade (GO:0046426)3.52991178
40NADH metabolic process (GO:0006734)3.52901558
41regulation of bile acid biosynthetic process (GO:0070857)3.49605819
42peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.45358380
43adult feeding behavior (GO:0008343)3.40871105
44postsynaptic membrane organization (GO:0001941)3.37639657
45regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 3.37121454
46negative regulation of complement activation (GO:0045916)3.35984975
47polyol catabolic process (GO:0046174)3.34357728
48positive regulation of endothelial cell differentiation (GO:0045603)3.31165567
49negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.30457329
50oxaloacetate metabolic process (GO:0006107)3.29141742
51cytoplasmic mRNA processing body assembly (GO:0033962)3.27851241
52endothelial cell proliferation (GO:0001935)3.26897367
53heparin biosynthetic process (GO:0030210)3.26762321
54heparin metabolic process (GO:0030202)3.26762321
55basement membrane organization (GO:0071711)3.26679412
56regulation of sulfur metabolic process (GO:0042762)3.25367816
57negative regulation of cell aging (GO:0090344)3.23346105
58regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.22814693
59negative regulation of platelet activation (GO:0010544)3.21291141
60regulation of cAMP-dependent protein kinase activity (GO:2000479)3.20688607
61nephron tubule formation (GO:0072079)3.18391298
62regulation of T-helper 2 cell differentiation (GO:0045628)3.17086907
63vascular endothelial growth factor signaling pathway (GO:0038084)3.15666333
64glomerular basement membrane development (GO:0032836)3.14413467
65tongue development (GO:0043586)3.13709089
66positive regulation of vasoconstriction (GO:0045907)3.10301573
67response to ischemia (GO:0002931)3.08958086
68lymphangiogenesis (GO:0001946)3.07458821
69regulation of anoikis (GO:2000209)3.06868329
70metanephric mesenchyme development (GO:0072075)3.06679965
71definitive hemopoiesis (GO:0060216)3.04689367
72heart trabecula formation (GO:0060347)3.03995991
73extracellular fibril organization (GO:0043206)3.03890016
74regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.02573499
75epithelial cell-cell adhesion (GO:0090136)3.02224548
76regulation of phospholipid biosynthetic process (GO:0071071)3.00931175
77pyrimidine dimer repair (GO:0006290)3.00811669
78cyclic purine nucleotide metabolic process (GO:0052652)2.99549078
79pancreas development (GO:0031016)2.98548813
80cornea development in camera-type eye (GO:0061303)2.97904500
81lung-associated mesenchyme development (GO:0060484)2.93925642
82polarized epithelial cell differentiation (GO:0030859)2.93516810
83regulation of cardiac muscle cell contraction (GO:0086004)2.91753054
84respiratory tube development (GO:0030323)2.90004246
85platelet dense granule organization (GO:0060155)2.89996747
86outer ear morphogenesis (GO:0042473)2.89281698
87response to pheromone (GO:0019236)2.89079242
88regulation of endothelial cell differentiation (GO:0045601)2.88713015
89positive regulation of glycolytic process (GO:0045821)2.88578470
90regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.86910955
91response to interferon-alpha (GO:0035455)2.86307525
92sprouting angiogenesis (GO:0002040)2.85422698
93regulation of respiratory burst (GO:0060263)2.85014454
94COPII vesicle coating (GO:0048208)2.84683199
95bone trabecula formation (GO:0060346)2.84465247
96cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.84304002
97mammary gland development (GO:0030879)2.83980624
98limb bud formation (GO:0060174)2.82613869
99stress fiber assembly (GO:0043149)2.82097186
100chondrocyte proliferation (GO:0035988)2.82037955
101negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.80827610
102endothelial cell differentiation (GO:0045446)2.79637669
103regulation of energy homeostasis (GO:2000505)2.78900518
104mesodermal cell differentiation (GO:0048333)2.78891630
105signal complex assembly (GO:0007172)2.78856465
106ovulation (GO:0030728)2.78632134
107cyclic nucleotide biosynthetic process (GO:0009190)2.76485453
108negative regulation of oxidoreductase activity (GO:0051354)2.76048225
109regulation of acyl-CoA biosynthetic process (GO:0050812)2.74956226
110ER overload response (GO:0006983)2.74617360
111cardiac left ventricle morphogenesis (GO:0003214)2.68683577
112response to hyperoxia (GO:0055093)2.67376052
113response to increased oxygen levels (GO:0036296)2.67376052
114respiratory system process (GO:0003016)2.66837230
115negative regulation of viral entry into host cell (GO:0046597)2.65287873
116negative regulation of androgen receptor signaling pathway (GO:0060766)2.65281850
117positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.64619017
118sequestering of extracellular ligand from receptor (GO:0035581)2.64546526
119glial cell proliferation (GO:0014009)2.62683663
120positive regulation of cellular response to insulin stimulus (GO:1900078)2.61668644
121thrombin receptor signaling pathway (GO:0070493)2.61645726
122smooth muscle tissue development (GO:0048745)2.59860667
123negative regulation of protein activation cascade (GO:2000258)2.59495885
124mitotic cell cycle arrest (GO:0071850)2.59485943
125barbed-end actin filament capping (GO:0051016)2.59273960
126body morphogenesis (GO:0010171)2.58571944
127negative regulation of type 2 immune response (GO:0002829)2.58042524
128regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.57812664
129regulation of amyloid precursor protein catabolic process (GO:1902991)2.57737365
130neurotransmitter-gated ion channel clustering (GO:0072578)2.55674671
131negative regulation of erythrocyte differentiation (GO:0045647)2.55375771
132positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.54859881
133regulation of nitric-oxide synthase activity (GO:0050999)2.54845183
134regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.54828366
135regulation of relaxation of muscle (GO:1901077)2.54345363
136cardiac muscle cell proliferation (GO:0060038)2.53671094
137positive regulation of insulin receptor signaling pathway (GO:0046628)2.53413278
138positive regulation of pseudopodium assembly (GO:0031274)2.53356556
139negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.52172926
140fibril organization (GO:0097435)2.51174011
141regulation of type B pancreatic cell apoptotic process (GO:2000674)2.50781813
142regulation of steroid hormone biosynthetic process (GO:0090030)2.50111103
143glutamate secretion (GO:0014047)2.49164783
144regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.48625705
145embryonic body morphogenesis (GO:0010172)2.48621759
146relaxation of muscle (GO:0090075)2.48327195
147genitalia morphogenesis (GO:0035112)2.48239969
148positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47945578
149cell adhesion mediated by integrin (GO:0033627)2.47095074
150auditory receptor cell stereocilium organization (GO:0060088)2.46596585
151embryonic forelimb morphogenesis (GO:0035115)2.46290936
152negative regulation of cytosolic calcium ion concentration (GO:0051481)2.45943058
153lung lobe morphogenesis (GO:0060463)2.45709425
154transcription from mitochondrial promoter (GO:0006390)2.45594627
155organ formation (GO:0048645)2.44832878
156cellular ketone body metabolic process (GO:0046950)2.42889853
157regulation of endothelial cell proliferation (GO:0001936)2.42614799
158cellular response to thyroid hormone stimulus (GO:0097067)2.40892146
159regulation of beta-amyloid formation (GO:1902003)2.40548706
160fibroblast migration (GO:0010761)2.40473934
161positive regulation of glycoprotein biosynthetic process (GO:0010560)2.40414639
162dermatan sulfate metabolic process (GO:0030205)2.40011268
163atrial cardiac muscle cell action potential (GO:0086014)2.39377893
164axon extension involved in axon guidance (GO:0048846)2.38995643
165neuron projection extension involved in neuron projection guidance (GO:1902284)2.38995643
166cytokine production involved in immune response (GO:0002367)2.38604667
167kidney mesenchyme development (GO:0072074)2.37802161
168regulation of cardioblast proliferation (GO:0003264)2.36603804
169regulation of secondary heart field cardioblast proliferation (GO:0003266)2.36603804
170receptor internalization (GO:0031623)2.36082788
171regulation of organ formation (GO:0003156)2.35472173
172regulation of smooth muscle cell differentiation (GO:0051150)2.34338144
173angiogenesis involved in wound healing (GO:0060055)2.34024326
174morphogenesis of an endothelium (GO:0003159)2.33857726
175endothelial tube morphogenesis (GO:0061154)2.33857726
176artery development (GO:0060840)2.33511832
177embryonic cranial skeleton morphogenesis (GO:0048701)2.33246396
178poly(A)+ mRNA export from nucleus (GO:0016973)2.32979023
179positive regulation of lipid kinase activity (GO:0090218)2.32620416
180auditory receptor cell differentiation (GO:0042491)2.32337244
181prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.31251285
182negative regulation of dendrite morphogenesis (GO:0050774)2.31089065
183single strand break repair (GO:0000012)2.30407959
184response to nitrosative stress (GO:0051409)2.30382903
185positive regulation of macroautophagy (GO:0016239)2.30371716
186regulation of female receptivity (GO:0045924)2.29750288
187negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.29684542
188DNA strand renaturation (GO:0000733)2.28795083
189regulation of T-helper 1 cell differentiation (GO:0045625)2.27749563
190organ induction (GO:0001759)2.27323760
191regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.27085254
192regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.26612349
193innervation (GO:0060384)2.23903924

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.57605162
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20730730
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.15017593
4FUS_26573619_Chip-Seq_HEK293_Human3.03230667
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87559433
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.74528925
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73374067
8TAF15_26573619_Chip-Seq_HEK293_Human2.68720693
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.66041344
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.52413848
11CHD7_19251738_ChIP-ChIP_MESCs_Mouse2.51484229
12CLOCK_20551151_ChIP-Seq_293T_Human2.47793061
13SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46062429
14ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.41855213
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.41271880
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.36844349
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.36111600
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.24222365
19AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.24018037
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21843745
21EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21843745
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20636639
23PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.19605773
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.15894063
25MTF2_20144788_ChIP-Seq_MESCs_Mouse2.09700038
26SMAD_19615063_ChIP-ChIP_OVARY_Human2.05343359
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04574982
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96978713
29EWS_26573619_Chip-Seq_HEK293_Human1.96184461
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.93069266
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.92864546
32TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.92734140
33VDR_22108803_ChIP-Seq_LS180_Human1.91650635
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.89821315
35DROSHA_22980978_ChIP-Seq_HELA_Human1.86455371
36SOX2_20726797_ChIP-Seq_SW620_Human1.86322194
37RBPJ_22232070_ChIP-Seq_NCS_Mouse1.85160870
38TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84771293
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84720005
40ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.84211187
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.79276486
42GATA1_22025678_ChIP-Seq_K562_Human1.78687390
43HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78203996
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.78012987
45SMAD4_21799915_ChIP-Seq_A2780_Human1.74427095
46GBX2_23144817_ChIP-Seq_PC3_Human1.72569458
47MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71321357
48TCF4_23295773_ChIP-Seq_U87_Human1.68342943
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.67993636
50CDX2_19796622_ChIP-Seq_MESCs_Mouse1.64153771
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.60740705
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.60731007
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57117146
54MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.56387960
55AHR_22903824_ChIP-Seq_MCF-7_Human1.55022994
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.53935403
57TOP2B_26459242_ChIP-Seq_MCF-7_Human1.53416581
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.53239865
59TP53_20018659_ChIP-ChIP_R1E_Mouse1.52846560
60JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51463208
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.51062126
62ARNT_22903824_ChIP-Seq_MCF-7_Human1.50531269
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49576126
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.48228677
65SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48211485
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.47958620
67SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47914130
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.47379323
69RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.46480098
70RXR_22108803_ChIP-Seq_LS180_Human1.45974590
71EZH2_27304074_Chip-Seq_ESCs_Mouse1.44347985
72PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.44136667
73TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.42744835
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42101448
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.40970465
76AR_21572438_ChIP-Seq_LNCaP_Human1.40646767
77SMAD3_21741376_ChIP-Seq_EPCs_Human1.38480243
78STAT3_23295773_ChIP-Seq_U87_Human1.36871743
79BCAT_22108803_ChIP-Seq_LS180_Human1.36632688
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.36257075
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.36058619
82NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35694653
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35085638
84FOXM1_26456572_ChIP-Seq_MCF-7_Human1.34186610
85EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.33220007
86EZH2_22144423_ChIP-Seq_EOC_Human1.31431202
87POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31102540
88TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31102540
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30806297
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.28489578
91E2F1_18555785_Chip-Seq_ESCs_Mouse1.27674683
92TP53_18474530_ChIP-ChIP_U2OS_Human1.27294781
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.27137282
94ZNF274_21170338_ChIP-Seq_K562_Hela1.26701334
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.25643679
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24446182
97SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24419195
98SCL_19346495_ChIP-Seq_HPC-7_Human1.24212197
99CJUN_26792858_Chip-Seq_BT549_Human1.23341785
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.23155479
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.23155479
102RUNX2_22187159_ChIP-Seq_PCA_Human1.22998849
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22511857
104ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22401845
105SA1_22415368_ChIP-Seq_MEFs_Mouse1.21284619
106STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21207848
107P53_22387025_ChIP-Seq_ESCs_Mouse1.20105440
108TCF4_18268006_ChIP-ChIP_LS174T_Human1.18649371
109SMAD4_21741376_ChIP-Seq_EPCs_Human1.18623340
110RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18148718
111WT1_19549856_ChIP-ChIP_CCG9911_Human1.17550314
112UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.17290448
113ERG_21242973_ChIP-ChIP_JURKAT_Human1.16735186
114ER_23166858_ChIP-Seq_MCF-7_Human1.16540698
115PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15764662
116ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.15745758
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15007506
118RING1B_27294783_Chip-Seq_ESCs_Mouse1.14657595
119CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14413361
120CTNNB1_20460455_ChIP-Seq_HCT116_Human1.13627487
121CTBP1_25329375_ChIP-Seq_LNCAP_Human1.12940745
122SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12814031
123AR_25329375_ChIP-Seq_VCAP_Human1.12156092
124TBL1_22424771_ChIP-Seq_293T_Human1.11454010
125NANOG_19829295_ChIP-Seq_ESCs_Human1.11414782
126SOX2_19829295_ChIP-Seq_ESCs_Human1.11414782
127TCF4_22108803_ChIP-Seq_LS180_Human1.10764095
128TBX20_22080862_ChIP-Seq_HEART_Mouse1.10372720
129TBX20_22328084_ChIP-Seq_HEART_Mouse1.10372720
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.10070167
131EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09868940
132SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08833912
133JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08695887
134SOX2_21211035_ChIP-Seq_LN229_Gbm1.08442033
135CMYC_18555785_Chip-Seq_ESCs_Mouse1.08103374
136GF1B_26923725_Chip-Seq_HPCs_Mouse1.07261152
137CBX2_27304074_Chip-Seq_ESCs_Mouse1.07013074
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.06902838
139CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06608478
140EOMES_21245162_ChIP-Seq_HESCs_Human1.06385029
141DNAJC2_21179169_ChIP-ChIP_NT2_Human1.06114969
142CDX2_22108803_ChIP-Seq_LS180_Human1.05667144
143ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05473302
144FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05307271
145SALL1_21062744_ChIP-ChIP_HESCs_Human1.04850752
146PIAS1_25552417_ChIP-Seq_VCAP_Human1.04004574
147TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.03711169
148NFE2_27457419_Chip-Seq_LIVER_Mouse1.03441432
149RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03178180
150KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02820648
151ISL1_27105846_Chip-Seq_CPCs_Mouse1.02722618
152NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02147481
153ZFP281_18757296_ChIP-ChIP_E14_Mouse1.00642037
154LXR_22292898_ChIP-Seq_THP-1_Human0.98210103
155EGR1_19032775_ChIP-ChIP_M12_Human0.98202715
156RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97842804
157PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97342435
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95757922
159P300_19829295_ChIP-Seq_ESCs_Human0.95422620
160BRD4_25478319_ChIP-Seq_HGPS_Human0.95100002
161TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.93619945
162SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.92371743
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.90845624
164NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89946757
165ESR1_20079471_ChIP-ChIP_T-47D_Human0.89623776
166SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86262768
167TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.86210781
168MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85829434
169SMC3_22415368_ChIP-Seq_MEFs_Mouse0.85456771
170WT1_25993318_ChIP-Seq_PODOCYTE_Human0.84441038
171PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.81179903
172ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80943771

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo6.12108649
2MP0003705_abnormal_hypodermis_morpholog5.40012766
3MP0003191_abnormal_cellular_cholesterol5.02900106
4MP0003283_abnormal_digestive_organ4.75045076
5MP0005360_urolithiasis4.57452323
6MP0003950_abnormal_plasma_membrane4.54284045
7MP0010368_abnormal_lymphatic_system3.83605816
8MP0001879_abnormal_lymphatic_vessel3.83033255
9MP0002332_abnormal_exercise_endurance3.35867195
10MP0003279_aneurysm3.14441783
11MP0003941_abnormal_skin_development2.98333197
12MP0004272_abnormal_basement_membrane2.90509780
13MP0003828_pulmonary_edema2.79861544
14MP0006138_congestive_heart_failure2.76425224
15MP0005167_abnormal_blood-brain_barrier2.67977649
16MP0004134_abnormal_chest_morphology2.62728706
17MP0001542_abnormal_bone_strength2.62533402
18MP0001293_anophthalmia2.54582493
19MP0003045_fibrosis2.52336816
20MP0008438_abnormal_cutaneous_collagen2.45615045
21MP0004147_increased_porphyrin_level2.42771806
22MP0000566_synostosis2.35783367
23MP0008057_abnormal_DNA_replication2.25901894
24MP0001853_heart_inflammation2.12623015
25MP0005220_abnormal_exocrine_pancreas2.11312451
26MP0000462_abnormal_digestive_system2.01069507
27MP0002234_abnormal_pharynx_morphology2.00734301
28MP0010386_abnormal_urinary_bladder1.95443749
29MP0005595_abnormal_vascular_smooth1.84477262
30MP0000428_abnormal_craniofacial_morphol1.82547864
31MP0004858_abnormal_nervous_system1.77125712
32MP0000383_abnormal_hair_follicle1.75885004
33MP0000767_abnormal_smooth_muscle1.75098088
34MP0010678_abnormal_skin_adnexa1.72528378
35MP0001299_abnormal_eye_distance/1.71499383
36MP0005171_absent_coat_pigmentation1.69676367
37MP0000372_irregular_coat_pigmentation1.68272667
38MP0002233_abnormal_nose_morphology1.64863315
39MP0004883_abnormal_blood_vessel1.64677418
40MP0010234_abnormal_vibrissa_follicle1.64130683
41MP0005165_increased_susceptibility_to1.63950463
42MP0009840_abnormal_foam_cell1.62374892
43MP0002697_abnormal_eye_size1.50708846
44MP0002254_reproductive_system_inflammat1.48646902
45MP0008872_abnormal_physiological_respon1.47897226
46MP0003119_abnormal_digestive_system1.47329869
47MP0006054_spinal_hemorrhage1.46673411
48MP0002938_white_spotting1.44717263
49MP0003075_altered_response_to1.43570432
50MP0005275_abnormal_skin_tensile1.43389791
51MP0001756_abnormal_urination1.41658602
52MP0003011_delayed_dark_adaptation1.39278925
53MP0001958_emphysema1.38907069
54MP0001984_abnormal_olfaction1.38450669
55MP0004036_abnormal_muscle_relaxation1.37671476
56MP0003937_abnormal_limbs/digits/tail_de1.37600992
57MP0004084_abnormal_cardiac_muscle1.37481264
58MP0001986_abnormal_taste_sensitivity1.35357103
59MP0000681_abnormal_thyroid_gland1.33366485
60MP0005551_abnormal_eye_electrophysiolog1.32460423
61MP0001661_extended_life_span1.31839427
62MP0008877_abnormal_DNA_methylation1.31223543
63MP0002877_abnormal_melanocyte_morpholog1.30461745
64MP0000751_myopathy1.30033231
65MP0001544_abnormal_cardiovascular_syste1.29871385
66MP0005385_cardiovascular_system_phenoty1.29871385
67MP0005503_abnormal_tendon_morphology1.26492974
68MP0009053_abnormal_anal_canal1.26121099
69MP0005164_abnormal_response_to1.23691330
70MP0003091_abnormal_cell_migration1.23588134
71MP0003122_maternal_imprinting1.23533938
72MP0002092_abnormal_eye_morphology1.23226550
73MP0003755_abnormal_palate_morphology1.20998659
74MP0009046_muscle_twitch1.20391888
75MP0000432_abnormal_head_morphology1.19980388
76MP0000013_abnormal_adipose_tissue1.18905822
77MP0003567_abnormal_fetal_cardiomyocyte1.18579837
78MP0003935_abnormal_craniofacial_develop1.17554912
79MP0004859_abnormal_synaptic_plasticity1.16618170
80MP0003942_abnormal_urinary_system1.14641224
81MP0001348_abnormal_lacrimal_gland1.12480496
82MP0002102_abnormal_ear_morphology1.12193468
83MP0003385_abnormal_body_wall1.12109963
84MP0009384_cardiac_valve_regurgitation1.11610369
85MP0002115_abnormal_skeleton_extremities1.10129153
86MP0000249_abnormal_blood_vessel1.08182875
87MP0005391_vision/eye_phenotype1.08049501
88MP0000343_altered_response_to1.05506240
89MP0002160_abnormal_reproductive_system1.03532875
90MP0000631_abnormal_neuroendocrine_gland1.02214461
91MP0000749_muscle_degeneration0.99596647
92MP0005620_abnormal_muscle_contractility0.97545111
93MP0002972_abnormal_cardiac_muscle0.97140530
94MP0003329_amyloid_beta_deposits0.96127807
95MP0001944_abnormal_pancreas_morphology0.94783971
96MP0002116_abnormal_craniofacial_bone0.94442412
97MP0005379_endocrine/exocrine_gland_phen0.94130872
98MP0003566_abnormal_cell_adhesion0.93329322
99MP0000230_abnormal_systemic_arterial0.92112914
100MP0001727_abnormal_embryo_implantation0.91359785
101MP0003787_abnormal_imprinting0.91256100
102MP0002837_dystrophic_cardiac_calcinosis0.91115317
103MP0001286_abnormal_eye_development0.89621720
104MP0008775_abnormal_heart_ventricle0.88378949
105MP0000604_amyloidosis0.88219396
106MP0001486_abnormal_startle_reflex0.88096235
107MP0003943_abnormal_hepatobiliary_system0.87188425
108MP0004215_abnormal_myocardial_fiber0.86933780
109MP0005332_abnormal_amino_acid0.86012127
110MP0005257_abnormal_intraocular_pressure0.84372696
111MP0005253_abnormal_eye_physiology0.83341717
112MP0005330_cardiomyopathy0.83188215
113MP0005023_abnormal_wound_healing0.82571117
114MP0002693_abnormal_pancreas_physiology0.80167753
115MP0006292_abnormal_olfactory_placode0.78855607
116MP0005266_abnormal_metabolism0.78788096
117MP0003880_abnormal_central_pattern0.78286197
118MP0009379_abnormal_foot_pigmentation0.78151779
119MP0002168_other_aberrant_phenotype0.77946449
120MP0002128_abnormal_blood_circulation0.77730819
121MP0002896_abnormal_bone_mineralization0.77280544
122MP0002295_abnormal_pulmonary_circulatio0.76926466
123MP0005623_abnormal_meninges_morphology0.76549220
124MP0006036_abnormal_mitochondrial_physio0.75691415
125MP0002133_abnormal_respiratory_system0.75636246
126MP0005388_respiratory_system_phenotype0.75636246
127MP0002109_abnormal_limb_morphology0.73943942
128MP0001501_abnormal_sleep_pattern0.73771512
129MP0001614_abnormal_blood_vessel0.73159317
130MP0001663_abnormal_digestive_system0.73111938
131MP0002127_abnormal_cardiovascular_syste0.72675575
132MP0002108_abnormal_muscle_morphology0.69957246
133MP0005670_abnormal_white_adipose0.69170369
134MP0009278_abnormal_bone_marrow0.68866182
135MP0001340_abnormal_eyelid_morphology0.68223514
136MP0003115_abnormal_respiratory_system0.67943319
137MP0009697_abnormal_copulation0.67042072
138MP0004130_abnormal_muscle_cell0.66419318
139MP0005187_abnormal_penis_morphology0.65545574
140MP0002177_abnormal_outer_ear0.64966000
141MP0002909_abnormal_adrenal_gland0.64494976
142MP0001533_abnormal_skeleton_physiology0.59538144
143MP0000465_gastrointestinal_hemorrhage0.57659038
144MP0004808_abnormal_hematopoietic_stem0.57076055
145MP0008875_abnormal_xenobiotic_pharmacok0.56982356
146MP0000163_abnormal_cartilage_morphology0.55801750
147MP0002925_abnormal_cardiovascular_devel0.55434379
148MP0005508_abnormal_skeleton_morphology0.54815595
149MP0009250_abnormal_appendicular_skeleto0.54481630
150MP0001485_abnormal_pinna_reflex0.53931703
151MP0001664_abnormal_digestion0.52503140
152MP0005174_abnormal_tail_pigmentation0.51715870
153MP0003878_abnormal_ear_physiology0.50819216
154MP0005377_hearing/vestibular/ear_phenot0.50819216
155MP0004484_altered_response_of0.50540475
156MP0002106_abnormal_muscle_physiology0.50393190
157MP0001270_distended_abdomen0.49833013
158MP0002971_abnormal_brown_adipose0.49490193
159MP0000759_abnormal_skeletal_muscle0.47116726
160MP0004510_myositis0.45981585
161MP0004085_abnormal_heartbeat0.45939455
162MP0001175_abnormal_lung_morphology0.45705861
163MP0004087_abnormal_muscle_fiber0.44699499

Predicted human phenotypes

RankGene SetZ-score
1Growth hormone excess (HP:0000845)5.29188626
2Broad metatarsal (HP:0001783)5.14747360
3Glucose intolerance (HP:0000833)4.76889804
4Reduced subcutaneous adipose tissue (HP:0003758)4.69995184
5Short nail (HP:0001799)4.21425312
6Xerostomia (HP:0000217)4.14260172
7Abnormality of the left ventricular outflow tract (HP:0011103)4.13929399
8Subaortic stenosis (HP:0001682)4.13929399
9Neoplasm of the adrenal cortex (HP:0100641)3.92930981
10Abnormal glucose tolerance (HP:0001952)3.79781630
11Orthostatic hypotension (HP:0001278)3.74104068
12Protrusio acetabuli (HP:0003179)3.69325899
13Camptodactyly of toe (HP:0001836)3.63801652
14Large hands (HP:0001176)3.58592788
15Conjugated hyperbilirubinemia (HP:0002908)3.47385375
16Polycythemia (HP:0001901)3.35611611
17Calcaneovalgus deformity (HP:0001848)3.29638971
18Mucosal telangiectasiae (HP:0100579)3.26498829
19Mesomelia (HP:0003027)3.25763650
20Prominent supraorbital ridges (HP:0000336)3.21665373
21Aortic regurgitation (HP:0001659)3.19044388
22Abnormality of dentin (HP:0010299)3.18827969
23Colon cancer (HP:0003003)3.16359492
24Cerebral hemorrhage (HP:0001342)3.12293906
25Hematochezia (HP:0002573)3.04404022
26Hypertensive crisis (HP:0100735)3.02212268
27Intestinal atresia (HP:0011100)3.00942110
28Deformed tarsal bones (HP:0008119)2.95560136
29Bone cyst (HP:0012062)2.92371109
30Radial bowing (HP:0002986)2.91914821
31Hypercholesterolemia (HP:0003124)2.82128230
32Acanthosis nigricans (HP:0000956)2.76739359
33Cervical subluxation (HP:0003308)2.76669215
34Vascular tortuosity (HP:0004948)2.73439052
35Focal motor seizures (HP:0011153)2.70920667
36Ketoacidosis (HP:0001993)2.70705226
37Pulmonary artery stenosis (HP:0004415)2.68651276
38Neonatal short-limb short stature (HP:0008921)2.68626510
39Shallow orbits (HP:0000586)2.68623732
40Flexion contracture of toe (HP:0005830)2.67684700
41Joint contractures involving the joints of the feet (HP:0100492)2.67684700
42Spontaneous hematomas (HP:0007420)2.67171175
43Neoplasm of the adrenal gland (HP:0100631)2.65538230
44Premature rupture of membranes (HP:0001788)2.64103257
45Hypoplastic left heart (HP:0004383)2.63675324
46Chondrocalcinosis (HP:0000934)2.62279223
47Hyperglycinuria (HP:0003108)2.58663482
48Chronic hepatic failure (HP:0100626)2.58058608
49Thoracolumbar scoliosis (HP:0002944)2.56240300
50Hypertriglyceridemia (HP:0002155)2.55832386
51Mild short stature (HP:0003502)2.54827256
52Abnormality of the phalanges of the 2nd finger (HP:0009541)2.53341802
53Arterial tortuosity (HP:0005116)2.51997886
54Hyperpituitarism (HP:0010514)2.49505253
55Malnutrition (HP:0004395)2.49175866
56Abnormality of the parietal bone (HP:0002696)2.48436129
57Hip dysplasia (HP:0001385)2.47279592
58Abnormality of Sharpey fibers (HP:0100685)2.43494326
59Hemiparesis (HP:0001269)2.43054181
60Vitreoretinal degeneration (HP:0000655)2.42066819
61Megalencephaly (HP:0001355)2.39289627
62Nonprogressive disorder (HP:0003680)2.38201308
63Acrocyanosis (HP:0001063)2.36286744
64Prolonged bleeding time (HP:0003010)2.34811068
65Humeroradial synostosis (HP:0003041)2.33947228
66Synostosis involving the elbow (HP:0003938)2.33947228
67Prostate neoplasm (HP:0100787)2.33465342
68Metaphyseal dysplasia (HP:0100255)2.31793541
69Long toe (HP:0010511)2.30681352
70Villous atrophy (HP:0011473)2.29074966
71Abnormality of small intestinal villus morphology (HP:0011472)2.29074966
72Aortic dissection (HP:0002647)2.28748802
73Abnormality of the lumbar spine (HP:0100712)2.28216930
74Broad palm (HP:0001169)2.27088954
75Hypoglycemic seizures (HP:0002173)2.26197015
76Abnormality of the calcaneus (HP:0008364)2.23381969
77Conjunctival telangiectasia (HP:0000524)2.20716746
78Bowing of the arm (HP:0006488)2.18373745
79Bowed forearm bones (HP:0003956)2.18373745
80Genital tract atresia (HP:0001827)2.17872491
81Soft skin (HP:0000977)2.17388348
82Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.16660509
83Abnormal rod and cone electroretinograms (HP:0008323)2.15213378
84Nephroblastoma (Wilms tumor) (HP:0002667)2.15111882
85Embryonal renal neoplasm (HP:0011794)2.14772934
86Increased density of long bones (HP:0006392)2.14505638
87Papillary thyroid carcinoma (HP:0002895)2.13833088
88Nephrogenic diabetes insipidus (HP:0009806)2.13604769
89Progressive cerebellar ataxia (HP:0002073)2.13542197
90Biconcave vertebral bodies (HP:0004586)2.11828462
91Redundant skin (HP:0001582)2.10212888
92Bilateral microphthalmos (HP:0007633)2.09590652
93Abnormality of proline metabolism (HP:0010907)2.08674074
94Hydroxyprolinuria (HP:0003080)2.08674074
95Increased variability in muscle fiber diameter (HP:0003557)2.08107323
96Retinal dysplasia (HP:0007973)2.06120963
97Increased connective tissue (HP:0009025)2.05718353
98Osteopenia (HP:0000938)2.03481615
99Vaginal atresia (HP:0000148)2.01038252
100Wormian bones (HP:0002645)2.00820726
101Pulmonary hypertension (HP:0002092)1.99335282
102Failure to thrive in infancy (HP:0001531)1.99160471
103Delayed closure of the anterior fontanelle (HP:0001476)1.99035631
104Spinal rigidity (HP:0003306)1.97812779
105Proximal tubulopathy (HP:0000114)1.97132423
106Esophageal varix (HP:0002040)1.96291833
107Focal seizures (HP:0007359)1.96010163
108Clonus (HP:0002169)1.95630264
109Beaking of vertebral bodies (HP:0004568)1.95028163
110Aortic aneurysm (HP:0004942)1.94485435
111Ectopia lentis (HP:0001083)1.94266964
112Irregular vertebral endplates (HP:0003301)1.93088016
113Visual hallucinations (HP:0002367)1.91917067
114Hydroureter (HP:0000072)1.91498038
115Late onset (HP:0003584)1.90850911
116Abnormal lung lobation (HP:0002101)1.90313059
117Right ventricular cardiomyopathy (HP:0011663)1.89823245
118Lipoatrophy (HP:0100578)1.89097514
119Neonatal hypoglycemia (HP:0001998)1.87781343
120Persistence of primary teeth (HP:0006335)1.87645891
121Abnormality of the ischium (HP:0003174)1.86434435
122Bronchomalacia (HP:0002780)1.86432655
123Severe visual impairment (HP:0001141)1.84843080
124Type 2 muscle fiber atrophy (HP:0003554)1.84837719
125Myelomeningocele (HP:0002475)1.84593716
126Hyperglycinemia (HP:0002154)1.84530937
127Adactyly (HP:0009776)1.84408046
128Hypoplastic heart (HP:0001961)1.83581299
129Pulmonary fibrosis (HP:0002206)1.83386742
130Renal tubular acidosis (HP:0001947)1.83283474
131Lip pit (HP:0100267)1.82901618
132Accelerated skeletal maturation (HP:0005616)1.82245511
133J-shaped sella turcica (HP:0002680)1.82043399
134Decreased muscle mass (HP:0003199)1.81213564
135Elbow flexion contracture (HP:0002987)1.80604576
136Absent eyelashes (HP:0000561)1.79954566
137Febrile seizures (HP:0002373)1.79792221
138Abnormality of the nasal mucosa (HP:0000433)1.79608179
139Abnormality of glycine metabolism (HP:0010895)1.78487624
140Abnormality of serine family amino acid metabolism (HP:0010894)1.78487624
141Hypoventilation (HP:0002791)1.77895338
142Neoplasm of the heart (HP:0100544)1.77644204
143Striae distensae (HP:0001065)1.77603096
144Asymmetry of the thorax (HP:0001555)1.76847845
145Disproportionate short-trunk short stature (HP:0003521)1.76453420
146Rectal prolapse (HP:0002035)1.76252144
147Osteomalacia (HP:0002749)1.76179042
148Ankle contracture (HP:0006466)1.75692216
149Heterochromia iridis (HP:0001100)1.75058841
150Myotonia (HP:0002486)1.74806310
151Aplasia/Hypoplasia of the fovea (HP:0008060)1.74232249
152Hypoplasia of the fovea (HP:0007750)1.74232249
153Limited hip movement (HP:0008800)1.74166739
154Insulin resistance (HP:0000855)1.73737082
155Benign neoplasm of the central nervous system (HP:0100835)1.73671143
156Bifid tongue (HP:0010297)1.73112461
157Gaze-evoked nystagmus (HP:0000640)1.72924867
158Hepatosplenomegaly (HP:0001433)1.72762943
159Hip contracture (HP:0003273)1.72315502
160Hepatoblastoma (HP:0002884)1.71729746
161Dilatation of the ascending aorta (HP:0005111)1.70024296
162Lower limb muscle weakness (HP:0007340)1.69568870
163Abnormality of skeletal muscle fiber size (HP:0012084)1.69502101
164Abnormality of the umbilical cord (HP:0010881)1.69485127
165Aneurysm (HP:0002617)1.69291474
166Osteolytic defects of the phalanges of the hand (HP:0009771)1.68655929
167Osteolytic defects of the hand bones (HP:0009699)1.68655929
168Wide nose (HP:0000445)1.68521504
169Wrist flexion contracture (HP:0001239)1.68249484
170Pterygium (HP:0001059)1.68053175
171Bundle branch block (HP:0011710)1.67095825
172Abnormality of midbrain morphology (HP:0002418)1.65859557
173Molar tooth sign on MRI (HP:0002419)1.65859557
174Hypoplastic ischia (HP:0003175)1.65791158
175Neoplasm of the colon (HP:0100273)1.65641350
176Bulbous nose (HP:0000414)1.65164741
177Arthropathy (HP:0003040)1.64947924
178Intellectual disability, moderate (HP:0002342)1.64103194
179Thyroid carcinoma (HP:0002890)1.63551647
180Narrow palate (HP:0000189)1.61998388
181Increased corneal curvature (HP:0100692)1.61992247
182Keratoconus (HP:0000563)1.61992247
183Nephronophthisis (HP:0000090)1.61573761
184Absent eyebrow (HP:0002223)1.61507751
185Enlarged kidneys (HP:0000105)1.61214983
186Neoplasm of the liver (HP:0002896)1.59767483
187Hyperextensible skin (HP:0000974)1.58174066
188Abnormality of the nasal septum (HP:0000419)1.56866485
189Enlarged penis (HP:0000040)1.56495829

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.62457727
2TAF15.67549359
3VRK24.74328656
4SMG14.31466839
5TGFBR14.26362906
6NUAK13.24495762
7LMTK23.07131182
8BRSK23.02707385
9TGFBR22.96576384
10CDK82.92658376
11FRK2.81217820
12PHKG22.72792808
13PHKG12.72792808
14MAPKAPK52.64857585
15DYRK32.53283630
16PTK2B2.46374343
17MST42.41642869
18PRPF4B2.38566928
19KDR2.32339063
20PIK3CG2.13116099
21BMPR1B2.10331388
22BCKDK2.09059309
23TAOK22.08360447
24PASK2.03564429
25EEF2K1.96640834
26MYLK1.93111922
27CDK191.86975119
28ARAF1.73572072
29EPHB11.71800820
30CSNK1G31.71350508
31FGFR21.62958991
32CSNK1G11.57444617
33CAMKK21.55987357
34FER1.53439909
35CSNK1A1L1.40475352
36MAP3K111.38741918
37PNCK1.37807317
38MAP3K121.37614692
39WNK31.37409273
40TRPM71.37178416
41PDK41.36171785
42PDK31.36171785
43ERN11.35964688
44CSNK1G21.35758881
45ACVR1B1.34937026
46PRKAA21.33125574
47ERBB31.30852415
48SIK31.25732573
49PKN21.25195169
50PIK3CA1.23322033
51VRK11.23282507
52PRKCH1.18800119
53DAPK11.17928197
54PDK21.16432007
55FGFR31.16407297
56HIPK21.15598697
57DDR21.12701766
58DYRK1A1.12460996
59PBK1.12367896
60MKNK21.11143348
61PAK41.07991156
62MATK1.07017669
63SIK11.04471346
64MAP4K11.00028057
65EPHB20.99801755
66DMPK0.98566010
67NEK90.98511059
68CDK90.97649880
69STK110.94479780
70CASK0.94122039
71EPHA30.92263134
72LATS10.90601884
73BRSK10.87060241
74MOS0.86288078
75MAPKAPK30.86232264
76LRRK20.86066469
77PRKD30.85302160
78KIT0.83527911
79FGFR10.83371149
80NME10.83000717
81PTK20.82047958
82MELK0.81188477
83DAPK30.80280383
84RPS6KB20.79729257
85MAP3K20.79417751
86PAK30.77573268
87PDGFRA0.77425620
88CAMK1G0.76464966
89NTRK30.75749925
90TRIM280.75283812
91IRAK10.72874468
92TRIB30.70238943
93DAPK20.69501968
94PDGFRB0.69382431
95TTN0.68897801
96ILK0.68883954
97SIK20.68209050
98STK38L0.66588051
99MAP3K30.66114196
100PRKG20.65597773
101ROCK20.64837350
102MINK10.64086262
103MAP3K10.62164991
104MAP2K40.60827537
105MAP2K70.60187471
106MAP2K10.58507349
107EPHA40.58299792
108RET0.57829460
109GRK10.56814903
110MAP2K30.56230318
111NLK0.56085779
112ERBB20.55083466
113PRKAA10.54207311
114INSR0.52198635
115CAMK2D0.51239317
116BMX0.51208792
117LIMK10.49648450
118YES10.49551871
119LATS20.49175960
120PTK60.49058604
121MAP3K40.48483538
122AKT30.48091326
123MAP3K60.45619616
124PLK30.45574821
125ADRBK10.44216407
126DYRK20.43351428
127STK30.43122036
128PRKD20.41430188
129SGK20.41275527
130SGK2230.40815022
131SGK4940.40815022
132ADRBK20.40648123
133RPS6KB10.40520591
134MAP3K90.40292076
135MET0.39225823
136BRAF0.38405039
137ZAK0.38391653
138OXSR10.38300905
139MUSK0.38236777
140PRKCE0.38203620
141RPS6KA20.37392924
142CAMK2B0.36032888
143RPS6KL10.35578555
144RPS6KC10.35578555
145RIPK10.35386917
146TNIK0.35234763
147NME20.35047997
148GRK50.34042387
149MKNK10.33615197
150SRC0.33339750
151MAP2K60.33231317
152IGF1R0.32703748
153RPS6KA60.32359819
154FGFR40.32002861
155SGK30.31714481
156GSK3A0.31489602
157CDK50.28813586
158PLK20.28773685
159GRK70.28441245
160ROCK10.26849251
161CDK120.26189748
162PRKCG0.24864413
163CHUK0.23713669
164CHEK20.23648418
165STK390.22147426

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.24084490
2Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.09155415
3Vitamin B6 metabolism_Homo sapiens_hsa007502.90750340
4Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.49597644
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.46443946
6Olfactory transduction_Homo sapiens_hsa047402.42108892
7Focal adhesion_Homo sapiens_hsa045102.14754305
8ECM-receptor interaction_Homo sapiens_hsa045122.13672533
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04067526
10Circadian rhythm_Homo sapiens_hsa047101.97647311
11Hedgehog signaling pathway_Homo sapiens_hsa043401.96900322
12Propanoate metabolism_Homo sapiens_hsa006401.93656255
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.85186361
14Basal cell carcinoma_Homo sapiens_hsa052171.81904842
15N-Glycan biosynthesis_Homo sapiens_hsa005101.73936759
16Ether lipid metabolism_Homo sapiens_hsa005651.70544107
17Fatty acid biosynthesis_Homo sapiens_hsa000611.66617544
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.66176724
19Circadian entrainment_Homo sapiens_hsa047131.61578468
20Dilated cardiomyopathy_Homo sapiens_hsa054141.61547295
21Synaptic vesicle cycle_Homo sapiens_hsa047211.60486738
22Platelet activation_Homo sapiens_hsa046111.59799436
23Pyruvate metabolism_Homo sapiens_hsa006201.53589044
24Renin secretion_Homo sapiens_hsa049241.52090584
25Adherens junction_Homo sapiens_hsa045201.51639650
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.50209749
27TGF-beta signaling pathway_Homo sapiens_hsa043501.49536069
28Proteoglycans in cancer_Homo sapiens_hsa052051.46793021
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46778285
30Rap1 signaling pathway_Homo sapiens_hsa040151.46176007
31Melanogenesis_Homo sapiens_hsa049161.45696803
32Linoleic acid metabolism_Homo sapiens_hsa005911.45348585
33Dorso-ventral axis formation_Homo sapiens_hsa043201.42035522
34Vibrio cholerae infection_Homo sapiens_hsa051101.40594772
35Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.37997329
36Salivary secretion_Homo sapiens_hsa049701.37976844
37PPAR signaling pathway_Homo sapiens_hsa033201.37520100
38Butanoate metabolism_Homo sapiens_hsa006501.36861354
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.35107744
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34779459
41Vascular smooth muscle contraction_Homo sapiens_hsa042701.34712268
42Fatty acid degradation_Homo sapiens_hsa000711.29675106
43Collecting duct acid secretion_Homo sapiens_hsa049661.29631435
44Fatty acid metabolism_Homo sapiens_hsa012121.27477356
45Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.26671631
46Protein export_Homo sapiens_hsa030601.25688030
47Taste transduction_Homo sapiens_hsa047421.25618051
48Pancreatic secretion_Homo sapiens_hsa049721.23286761
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20388306
50Tight junction_Homo sapiens_hsa045301.19278773
51Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.18615934
52Fatty acid elongation_Homo sapiens_hsa000621.16389054
53Viral myocarditis_Homo sapiens_hsa054161.16271560
54Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16029211
55Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.15185294
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14203194
57cGMP-PKG signaling pathway_Homo sapiens_hsa040221.14184280
58Gap junction_Homo sapiens_hsa045401.12401012
59Regulation of autophagy_Homo sapiens_hsa041401.10731109
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.09706703
61Thyroid hormone signaling pathway_Homo sapiens_hsa049191.07697460
62Morphine addiction_Homo sapiens_hsa050321.05615665
63Retinol metabolism_Homo sapiens_hsa008301.05542027
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.05033873
65Hippo signaling pathway_Homo sapiens_hsa043901.03399511
66Gastric acid secretion_Homo sapiens_hsa049711.00853532
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00238049
68Calcium signaling pathway_Homo sapiens_hsa040200.98499590
69cAMP signaling pathway_Homo sapiens_hsa040240.98110924
70Long-term depression_Homo sapiens_hsa047300.97883192
71Wnt signaling pathway_Homo sapiens_hsa043100.95733091
72Amphetamine addiction_Homo sapiens_hsa050310.95567202
73Long-term potentiation_Homo sapiens_hsa047200.95524291
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94989499
75Tryptophan metabolism_Homo sapiens_hsa003800.94464977
76Complement and coagulation cascades_Homo sapiens_hsa046100.94074102
77Malaria_Homo sapiens_hsa051440.92983463
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.92686251
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.90293159
80Histidine metabolism_Homo sapiens_hsa003400.89774259
81Selenocompound metabolism_Homo sapiens_hsa004500.89594673
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.89073563
83Carbon metabolism_Homo sapiens_hsa012000.88651461
84Endometrial cancer_Homo sapiens_hsa052130.87685371
85Serotonergic synapse_Homo sapiens_hsa047260.87447830
86Phototransduction_Homo sapiens_hsa047440.86757358
87Rheumatoid arthritis_Homo sapiens_hsa053230.86428343
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85791238
89Ras signaling pathway_Homo sapiens_hsa040140.85149665
90Axon guidance_Homo sapiens_hsa043600.85090216
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84897300
92Oxidative phosphorylation_Homo sapiens_hsa001900.84769075
93Glucagon signaling pathway_Homo sapiens_hsa049220.84656817
94Glutamatergic synapse_Homo sapiens_hsa047240.84347039
95Thyroid hormone synthesis_Homo sapiens_hsa049180.83981138
96GABAergic synapse_Homo sapiens_hsa047270.83807274
97Mineral absorption_Homo sapiens_hsa049780.83756066
98GnRH signaling pathway_Homo sapiens_hsa049120.83646818
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.81861206
100Vitamin digestion and absorption_Homo sapiens_hsa049770.81674317
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.81492646
102Melanoma_Homo sapiens_hsa052180.79884466
103Parkinsons disease_Homo sapiens_hsa050120.76580214
104Folate biosynthesis_Homo sapiens_hsa007900.76175845
105Leukocyte transendothelial migration_Homo sapiens_hsa046700.76171938
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74622463
107Sulfur metabolism_Homo sapiens_hsa009200.74297065
108Arginine and proline metabolism_Homo sapiens_hsa003300.72470751
109Oocyte meiosis_Homo sapiens_hsa041140.72440144
110Prostate cancer_Homo sapiens_hsa052150.72377632
111RNA degradation_Homo sapiens_hsa030180.72262963
112AMPK signaling pathway_Homo sapiens_hsa041520.72198170
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.72003110
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70894216
115Dopaminergic synapse_Homo sapiens_hsa047280.69709711
116Endocytosis_Homo sapiens_hsa041440.69452579
117Sphingolipid metabolism_Homo sapiens_hsa006000.68963269
118Shigellosis_Homo sapiens_hsa051310.68015333
119Insulin secretion_Homo sapiens_hsa049110.67979589
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.66591247
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64893262
122Nicotine addiction_Homo sapiens_hsa050330.63479519
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.62527590
124Thyroid cancer_Homo sapiens_hsa052160.61789364
125Cholinergic synapse_Homo sapiens_hsa047250.61240244
126VEGF signaling pathway_Homo sapiens_hsa043700.61161933
127Oxytocin signaling pathway_Homo sapiens_hsa049210.60967241
128Nitrogen metabolism_Homo sapiens_hsa009100.60116463
129Bile secretion_Homo sapiens_hsa049760.59951130
130Alzheimers disease_Homo sapiens_hsa050100.59471432
131Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59355521
132African trypanosomiasis_Homo sapiens_hsa051430.59029630
133ABC transporters_Homo sapiens_hsa020100.56538294
134Ovarian steroidogenesis_Homo sapiens_hsa049130.56450393
135Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56208931
136Phospholipase D signaling pathway_Homo sapiens_hsa040720.56035831
137HIF-1 signaling pathway_Homo sapiens_hsa040660.55860287
138Cocaine addiction_Homo sapiens_hsa050300.55561786
139Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.55394415
140Phagosome_Homo sapiens_hsa041450.55182280
141Longevity regulating pathway - mammal_Homo sapiens_hsa042110.54974633
142beta-Alanine metabolism_Homo sapiens_hsa004100.54061846
143Hematopoietic cell lineage_Homo sapiens_hsa046400.53612419
144Sulfur relay system_Homo sapiens_hsa041220.53377476
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52939611
146Insulin resistance_Homo sapiens_hsa049310.52152594
147Peroxisome_Homo sapiens_hsa041460.51980868
148Prion diseases_Homo sapiens_hsa050200.50776966
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48142484
150FoxO signaling pathway_Homo sapiens_hsa040680.47599351
151Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47213195
152One carbon pool by folate_Homo sapiens_hsa006700.46543193
153Cardiac muscle contraction_Homo sapiens_hsa042600.46522357
154Central carbon metabolism in cancer_Homo sapiens_hsa052300.43489069
155Amoebiasis_Homo sapiens_hsa051460.42345473
156Protein digestion and absorption_Homo sapiens_hsa049740.41896518

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