METTL25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)5.23424538
2ribosomal small subunit assembly (GO:0000028)4.59387249
3piRNA metabolic process (GO:0034587)4.44085845
4DNA strand elongation (GO:0022616)4.21002121
5signal peptide processing (GO:0006465)4.18393569
6telomere maintenance via semi-conservative replication (GO:0032201)4.16599511
7proteasome assembly (GO:0043248)4.14555293
8deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.13187345
9DNA strand elongation involved in DNA replication (GO:0006271)4.10877266
10synapsis (GO:0007129)4.10087860
11CENP-A containing nucleosome assembly (GO:0034080)3.99326712
12formation of translation preinitiation complex (GO:0001731)3.95371682
13maturation of SSU-rRNA (GO:0030490)3.89577506
14chromatin remodeling at centromere (GO:0031055)3.89474047
15telomere maintenance via telomere lengthening (GO:0010833)3.89298122
16telomere maintenance via recombination (GO:0000722)3.85822566
17RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.83131993
18DNA replication initiation (GO:0006270)3.82276161
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.75956328
20ribosomal large subunit biogenesis (GO:0042273)3.75054052
21attachment of spindle microtubules to kinetochore (GO:0008608)3.71313861
22tachykinin receptor signaling pathway (GO:0007217)3.67981032
23mitotic metaphase plate congression (GO:0007080)3.60799025
24DNA replication-independent nucleosome organization (GO:0034724)3.60673892
25DNA replication-independent nucleosome assembly (GO:0006336)3.60673892
26mitotic recombination (GO:0006312)3.59646064
27spliceosomal snRNP assembly (GO:0000387)3.52155246
28protein neddylation (GO:0045116)3.51840685
29negative regulation of DNA-dependent DNA replication (GO:2000104)3.47023926
30viral transcription (GO:0019083)3.46057145
31DNA unwinding involved in DNA replication (GO:0006268)3.44196625
32protein localization to kinetochore (GO:0034501)3.43791417
33telomere maintenance via telomerase (GO:0007004)3.42234023
34histone mRNA metabolic process (GO:0008334)3.41279773
35spliceosomal complex assembly (GO:0000245)3.41083434
36translational termination (GO:0006415)3.39286331
37regulation of nuclear cell cycle DNA replication (GO:0033262)3.36126941
38metaphase plate congression (GO:0051310)3.35736691
39kinetochore organization (GO:0051383)3.32778162
40ribonucleoprotein complex biogenesis (GO:0022613)3.30529333
41ribosomal small subunit biogenesis (GO:0042274)3.30332629
42kinetochore assembly (GO:0051382)3.29274829
43nucleotide-excision repair, DNA gap filling (GO:0006297)3.28751177
44DNA replication checkpoint (GO:0000076)3.27182713
45respiratory chain complex IV assembly (GO:0008535)3.25553667
46DNA replication-dependent nucleosome assembly (GO:0006335)3.24628222
47DNA replication-dependent nucleosome organization (GO:0034723)3.24628222
48IMP biosynthetic process (GO:0006188)3.23067688
49viral mRNA export from host cell nucleus (GO:0046784)3.22785330
50ribosome biogenesis (GO:0042254)3.19572639
51mitotic nuclear envelope disassembly (GO:0007077)3.18642489
52ribosome assembly (GO:0042255)3.17992555
53histone exchange (GO:0043486)3.17980856
54rRNA processing (GO:0006364)3.17680383
55translational elongation (GO:0006414)3.17650891
56folic acid-containing compound biosynthetic process (GO:0009396)3.15025588
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14030660
58transcription-coupled nucleotide-excision repair (GO:0006283)3.13082465
59translational initiation (GO:0006413)3.11940848
60rRNA modification (GO:0000154)3.11587881
61termination of RNA polymerase III transcription (GO:0006386)3.11212513
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.11212513
63axoneme assembly (GO:0035082)3.10431401
64nucleobase biosynthetic process (GO:0046112)3.09867478
65RNA-dependent DNA replication (GO:0006278)3.09115734
66rRNA metabolic process (GO:0016072)3.08151181
67regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.07016642
68regulation of mitotic spindle checkpoint (GO:1903504)3.07016642
69anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.06895550
70cotranslational protein targeting to membrane (GO:0006613)3.06169167
71negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05450931
72maturation of 5.8S rRNA (GO:0000460)3.05223738
73rRNA catabolic process (GO:0016075)3.05022782
74histone H2A acetylation (GO:0043968)3.04449219
75telomere maintenance (GO:0000723)3.02348075
76regulation of helicase activity (GO:0051095)3.02295862
77protein targeting to ER (GO:0045047)3.02179199
78protein localization to chromosome, centromeric region (GO:0071459)3.01606862
79telomere organization (GO:0032200)3.01015960
80platelet dense granule organization (GO:0060155)3.00839731
81adenosine metabolic process (GO:0046085)3.00685613
82prenylation (GO:0097354)3.00283597
83protein prenylation (GO:0018342)3.00283597
84regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.00014758
85DNA ligation (GO:0006266)2.99362094
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.98549018
87resolution of meiotic recombination intermediates (GO:0000712)2.97002677
88indole-containing compound catabolic process (GO:0042436)2.96196550
89indolalkylamine catabolic process (GO:0046218)2.96196550
90tryptophan catabolic process (GO:0006569)2.96196550
91DNA double-strand break processing (GO:0000729)2.96150317
92protein deneddylation (GO:0000338)2.92661034
93regulation of meiosis I (GO:0060631)2.92410190
94reciprocal meiotic recombination (GO:0007131)2.92297781
95reciprocal DNA recombination (GO:0035825)2.92297781
96protein localization to endoplasmic reticulum (GO:0070972)2.91765157
97histone mRNA catabolic process (GO:0071044)2.91405025
98positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91240447
99exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.90683327
100nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.90616873
101photoreceptor cell maintenance (GO:0045494)2.88926957
102tRNA methylation (GO:0030488)2.88553173
103purine nucleobase biosynthetic process (GO:0009113)2.87817083
104membrane disassembly (GO:0030397)2.87542229
105nuclear envelope disassembly (GO:0051081)2.87542229
106RNA splicing, via transesterification reactions (GO:0000375)2.87092040
107indolalkylamine metabolic process (GO:0006586)2.86187022
108lactate metabolic process (GO:0006089)2.86118230
109male meiosis (GO:0007140)2.85660995
110establishment of protein localization to mitochondrial membrane (GO:0090151)2.84798909
111establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84705341
112water-soluble vitamin biosynthetic process (GO:0042364)2.84369426
113mitochondrial DNA replication (GO:0006264)2.84316462
114mRNA splicing, via spliceosome (GO:0000398)2.82815100
115RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82815100
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.82776432
117somatic diversification of immune receptors via somatic mutation (GO:0002566)2.82776432
118regulation of mitochondrial translation (GO:0070129)2.82600366
119DNA methylation involved in gamete generation (GO:0043046)2.82411061
120negative regulation of mitotic sister chromatid separation (GO:2000816)2.82292158
121negative regulation of mitotic sister chromatid segregation (GO:0033048)2.82292158
122negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.82292158
123negative regulation of sister chromatid segregation (GO:0033046)2.82292158
124cullin deneddylation (GO:0010388)2.81839942
125regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.81328510
126somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.80319722
127isotype switching (GO:0045190)2.80319722
128somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.80319722
129pseudouridine synthesis (GO:0001522)2.79725500
130negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78914977
131negative regulation of chromosome segregation (GO:0051985)2.78751139
132negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.78684998
133regulation of spindle organization (GO:0090224)2.77820807
134mitotic spindle assembly checkpoint (GO:0007094)2.76404988
135nuclear pore organization (GO:0006999)2.75399891
136mitotic G2/M transition checkpoint (GO:0044818)2.75324276
137nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75058704
138viral life cycle (GO:0019058)2.74625409
139negative regulation of ligase activity (GO:0051352)2.74198698
140negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.74198698
141centriole replication (GO:0007099)2.74158576
142cilium or flagellum-dependent cell motility (GO:0001539)2.72269215
143cytochrome complex assembly (GO:0017004)2.71694965
144mitotic G2 DNA damage checkpoint (GO:0007095)2.71413392
145male meiosis I (GO:0007141)2.71179768
146mitotic spindle checkpoint (GO:0071174)2.69777164
147regulation of mesoderm development (GO:2000380)2.68709673
148establishment of protein localization to Golgi (GO:0072600)2.66941181
149regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65881666
150meiosis I (GO:0007127)2.62788572
151regulation of acyl-CoA biosynthetic process (GO:0050812)2.61745202
152spindle checkpoint (GO:0031577)2.61493461
153double-strand break repair via homologous recombination (GO:0000724)2.61441712
154rRNA methylation (GO:0031167)2.59162970
155DNA damage response, detection of DNA damage (GO:0042769)2.57997079
156recombinational repair (GO:0000725)2.57637980
157peptidyl-histidine modification (GO:0018202)2.56261127
158tryptophan metabolic process (GO:0006568)2.55417974
159protein K11-linked ubiquitination (GO:0070979)2.55146816
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.54203950
161tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.53216255
162RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.53216255
163replicative senescence (GO:0090399)2.49906624
164replication fork processing (GO:0031297)2.49410736
165protein complex biogenesis (GO:0070271)2.49312939
166purine-containing compound salvage (GO:0043101)2.48747796
167spindle assembly checkpoint (GO:0071173)2.48326342
168mitochondrial respiratory chain complex I assembly (GO:0032981)2.46579718
169NADH dehydrogenase complex assembly (GO:0010257)2.46579718
170mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.46579718
171S-adenosylmethionine metabolic process (GO:0046500)2.44695611
172fucose catabolic process (GO:0019317)2.44642646
173L-fucose metabolic process (GO:0042354)2.44642646
174L-fucose catabolic process (GO:0042355)2.44642646
175methionine biosynthetic process (GO:0009086)2.44624289
176response to pheromone (GO:0019236)2.43925310

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.59927815
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.11276650
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47060656
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27751502
5MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.27709256
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.25734575
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.19237602
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18674809
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.11108997
10GABP_17652178_ChIP-ChIP_JURKAT_Human3.08879608
11IGF1R_20145208_ChIP-Seq_DFB_Human3.04754414
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.94534811
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.91322802
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87685052
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.87469395
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.81196915
17VDR_22108803_ChIP-Seq_LS180_Human2.74545381
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.73184624
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.66289059
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.57129767
21ZNF274_21170338_ChIP-Seq_K562_Hela2.54378796
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.51449340
23FLI1_27457419_Chip-Seq_LIVER_Mouse2.50385815
24VDR_23849224_ChIP-Seq_CD4+_Human2.39566728
25CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.37413691
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37269820
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36806230
28EWS_26573619_Chip-Seq_HEK293_Human2.36169430
29NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.34806414
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29330600
31ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19556397
32XRN2_22483619_ChIP-Seq_HELA_Human2.16784799
33PCGF2_27294783_Chip-Seq_ESCs_Mouse2.16675829
34FOXP3_21729870_ChIP-Seq_TREG_Human2.14767476
35TAF15_26573619_Chip-Seq_HEK293_Human2.13468516
36ZFP57_27257070_Chip-Seq_ESCs_Mouse2.12682377
37GBX2_23144817_ChIP-Seq_PC3_Human2.09769667
38E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08635015
39EGR1_19374776_ChIP-ChIP_THP-1_Human2.06836918
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.06371111
41* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.03623384
42FUS_26573619_Chip-Seq_HEK293_Human2.03023273
43DCP1A_22483619_ChIP-Seq_HELA_Human1.99264979
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.98506293
45P300_19829295_ChIP-Seq_ESCs_Human1.95194688
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94153106
47GABP_19822575_ChIP-Seq_HepG2_Human1.84595655
48CIITA_25753668_ChIP-Seq_RAJI_Human1.82599873
49SRF_21415370_ChIP-Seq_HL-1_Mouse1.82134268
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.81395305
51TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80869710
52TTF2_22483619_ChIP-Seq_HELA_Human1.80479992
53E2F1_21310950_ChIP-Seq_MCF-7_Human1.80375736
54MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80221934
55BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.79943702
56EZH2_27294783_Chip-Seq_NPCs_Mouse1.77760127
57THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76485692
58YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76210656
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.76068799
60GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.72765508
61AR_21909140_ChIP-Seq_LNCAP_Human1.71796767
62ELK1_19687146_ChIP-ChIP_HELA_Human1.71468990
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.71055247
64ER_23166858_ChIP-Seq_MCF-7_Human1.69196136
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.68736478
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64418990
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.64194655
68YY1_21170310_ChIP-Seq_MESCs_Mouse1.63473800
69FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.62903827
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.61355649
71SUZ12_27294783_Chip-Seq_NPCs_Mouse1.60901247
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60394773
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.59744754
74NANOG_18555785_ChIP-Seq_MESCs_Mouse1.58958955
75NFE2_27457419_Chip-Seq_LIVER_Mouse1.56402662
76NOTCH1_21737748_ChIP-Seq_TLL_Human1.54835664
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54191414
78CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53483958
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.53379989
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53376204
81KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51737340
82MYC_22102868_ChIP-Seq_BL_Human1.47745882
83PIAS1_25552417_ChIP-Seq_VCAP_Human1.43147455
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.41588028
85CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40161231
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39523414
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39137822
88CBP_20019798_ChIP-Seq_JUKART_Human1.38984719
89IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38984719
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.37425325
91CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36733985
92KDM5A_27292631_Chip-Seq_BREAST_Human1.34579346
93STAT3_23295773_ChIP-Seq_U87_Human1.33797923
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33125930
95CRX_20693478_ChIP-Seq_RETINA_Mouse1.32120329
96GATA1_22025678_ChIP-Seq_K562_Human1.29964237
97TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29622113
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29426500
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.29095507
100EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26867092
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.26806408
102SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.26646740
103NANOG_19829295_ChIP-Seq_ESCs_Human1.26527190
104SOX2_19829295_ChIP-Seq_ESCs_Human1.26527190
105CDX2_22108803_ChIP-Seq_LS180_Human1.26445429
106SMAD4_21799915_ChIP-Seq_A2780_Human1.25048459
107TCF4_22108803_ChIP-Seq_LS180_Human1.24916793
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23996748
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23993173
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23036309
111FOXM1_26456572_ChIP-Seq_MCF-7_Human1.22784218
112SPI1_23547873_ChIP-Seq_NB4_Human1.22359434
113BCAT_22108803_ChIP-Seq_LS180_Human1.22038954
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21469400
115TFEB_21752829_ChIP-Seq_HELA_Human1.20740519
116KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20730529
117SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19876605
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19646848
119FLI1_21867929_ChIP-Seq_TH2_Mouse1.19504408
120OCT4_21477851_ChIP-Seq_ESCs_Mouse1.19463858
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19332670
122FOXA1_25329375_ChIP-Seq_VCAP_Human1.19332670
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19026820
124E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19014777
125SMAD3_21741376_ChIP-Seq_EPCs_Human1.18269036
126E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.18084982
127E2F1_18555785_Chip-Seq_ESCs_Mouse1.16920835
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16661635
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.16562637
130SALL4_22934838_ChIP-ChIP_CD34+_Human1.16187122
131TCF4_23295773_ChIP-Seq_U87_Human1.16038050
132SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.15939587
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15644056
134SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15106372
135SMAD_19615063_ChIP-ChIP_OVARY_Human1.14515143
136GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14115717
137MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13712075
138TP53_22573176_ChIP-Seq_HFKS_Human1.13581716
139TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12899448
140P53_22387025_ChIP-Seq_ESCs_Mouse1.11429114
141ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.10051902
142TP63_19390658_ChIP-ChIP_HaCaT_Human1.09614126
143TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09502115
144IRF8_22096565_ChIP-ChIP_GC-B_Human1.09235126
145MYC_18940864_ChIP-ChIP_HL60_Human1.08377103
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08160853
147NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08054009
148FOXA1_21572438_ChIP-Seq_LNCaP_Human1.07746631
149PRDM14_20953172_ChIP-Seq_ESCs_Human1.07618751
150CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.07232841
151SCL_19346495_ChIP-Seq_HPC-7_Human1.06091824
152GATA3_26560356_Chip-Seq_TH2_Human1.05663028
153IRF1_19129219_ChIP-ChIP_H3396_Human1.05557802
154CMYC_18555785_Chip-Seq_ESCs_Mouse1.05520005
155STAT3_18555785_Chip-Seq_ESCs_Mouse1.05380106
156P300_18555785_Chip-Seq_ESCs_Mouse1.04614863
157DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.02914771
158CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.01138092
159SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00815283
160KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00807364
161HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.00207148
162BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00172592
163CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.99383888
164ELK1_22589737_ChIP-Seq_MCF10A_Human0.99323889
165KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94811135
166SALL1_21062744_ChIP-ChIP_HESCs_Human0.93691326
167VDR_21846776_ChIP-Seq_THP-1_Human0.92325946
168CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91068299
169SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89598927
170STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89481138
171CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88820721
172MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.87244681
173RBPJ_22232070_ChIP-Seq_NCS_Mouse0.86382703
174FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85147227
175NANOG_21062744_ChIP-ChIP_HESCs_Human0.83110958
176SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.82098190
177TBX5_21415370_ChIP-Seq_HL-1_Mouse0.77738966
178IRF8_21731497_ChIP-ChIP_J774_Mouse0.76312152

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.00424930
2MP0010094_abnormal_chromosome_stability4.30917116
3MP0003111_abnormal_nucleus_morphology4.06918534
4MP0008058_abnormal_DNA_repair4.00163684
5MP0008057_abnormal_DNA_replication3.56027621
6MP0004957_abnormal_blastocyst_morpholog3.55517386
7MP0003077_abnormal_cell_cycle3.54566434
8MP0003195_calcinosis2.97236654
9MP0008007_abnormal_cellular_replicative2.94529067
10MP0000569_abnormal_digit_pigmentation2.59524911
11MP0002396_abnormal_hematopoietic_system2.53070146
12MP0000372_irregular_coat_pigmentation2.39327356
13MP0002102_abnormal_ear_morphology2.33352508
14MP0008932_abnormal_embryonic_tissue2.25249327
15MP0003786_premature_aging2.24671316
16MP0008877_abnormal_DNA_methylation2.24357537
17MP0003806_abnormal_nucleotide_metabolis2.20137134
18MP0000383_abnormal_hair_follicle2.13392829
19MP0004808_abnormal_hematopoietic_stem2.06796186
20MP0005075_abnormal_melanosome_morpholog2.05528432
21MP0009697_abnormal_copulation2.03903168
22MP0000490_abnormal_crypts_of2.03872718
23MP0003123_paternal_imprinting1.97386348
24MP0005253_abnormal_eye_physiology1.91195872
25MP0003646_muscle_fatigue1.90392322
26MP0000427_abnormal_hair_cycle1.89971897
27MP0002138_abnormal_hepatobiliary_system1.88963790
28MP0000350_abnormal_cell_proliferation1.87399090
29MP0010352_gastrointestinal_tract_polyps1.76695974
30MP0006292_abnormal_olfactory_placode1.76203672
31MP0001730_embryonic_growth_arrest1.72006038
32MP0005551_abnormal_eye_electrophysiolog1.71920934
33MP0003763_abnormal_thymus_physiology1.71217428
34MP0010307_abnormal_tumor_latency1.69320732
35MP0004147_increased_porphyrin_level1.66707865
36MP0010678_abnormal_skin_adnexa1.64892934
37MP0001835_abnormal_antigen_presentation1.64156059
38MP0003890_abnormal_embryonic-extraembry1.60397601
39MP0002736_abnormal_nociception_after1.59379335
40MP0006036_abnormal_mitochondrial_physio1.57492404
41MP0000313_abnormal_cell_death1.52061201
42MP0001984_abnormal_olfaction1.51325513
43MP0002398_abnormal_bone_marrow1.50216074
44MP0009333_abnormal_splenocyte_physiolog1.49100613
45MP0002019_abnormal_tumor_incidence1.45130314
46MP0010386_abnormal_urinary_bladder1.40615446
47MP0002210_abnormal_sex_determination1.39410095
48MP0000703_abnormal_thymus_morphology1.38887595
49MP0005084_abnormal_gallbladder_morpholo1.36630343
50MP0000689_abnormal_spleen_morphology1.36393168
51MP0001545_abnormal_hematopoietic_system1.36194903
52MP0005397_hematopoietic_system_phenotyp1.36194903
53MP0002095_abnormal_skin_pigmentation1.34531590
54MP0002722_abnormal_immune_system1.33230778
55MP0002837_dystrophic_cardiac_calcinosis1.32489833
56MP0001697_abnormal_embryo_size1.31296653
57MP0004215_abnormal_myocardial_fiber1.30607638
58MP0001968_abnormal_touch/_nociception1.29964722
59MP0004381_abnormal_hair_follicle1.27914973
60MP0001145_abnormal_male_reproductive1.27185727
61MP0006035_abnormal_mitochondrial_morpho1.26644749
62MP0002080_prenatal_lethality1.26347768
63MP0004145_abnormal_muscle_electrophysio1.24710679
64MP0003186_abnormal_redox_activity1.24324378
65MP0001929_abnormal_gametogenesis1.23399515
66MP0003121_genomic_imprinting1.21283518
67MP0002085_abnormal_embryonic_tissue1.18607645
68MP0005380_embryogenesis_phenotype1.15536104
69MP0001672_abnormal_embryogenesis/_devel1.15536104
70MP0006054_spinal_hemorrhage1.15383927
71MP0000015_abnormal_ear_pigmentation1.15095234
72MP0003724_increased_susceptibility_to1.14376080
73MP0002429_abnormal_blood_cell1.13151566
74MP0000716_abnormal_immune_system1.13076521
75MP0004133_heterotaxia1.12012299
76MP0000653_abnormal_sex_gland1.11871499
77MP0001800_abnormal_humoral_immune1.11227130
78MP0002084_abnormal_developmental_patter1.09730028
79MP0003315_abnormal_perineum_morphology1.09253188
80MP0005671_abnormal_response_to1.09062714
81MP0001790_abnormal_immune_system1.08264361
82MP0005387_immune_system_phenotype1.08264361
83MP0001485_abnormal_pinna_reflex1.06643849
84MP0004036_abnormal_muscle_relaxation1.05637167
85MP0001293_anophthalmia1.05268290
86MP0005174_abnormal_tail_pigmentation1.05254707
87MP0004233_abnormal_muscle_weight1.04774044
88MP0003984_embryonic_growth_retardation1.02013639
89MP0002127_abnormal_cardiovascular_syste1.01789298
90MP0003656_abnormal_erythrocyte_physiolo0.99895628
91MP0005360_urolithiasis0.99769171
92MP0001756_abnormal_urination0.99615143
93MP0000685_abnormal_immune_system0.99319305
94MP0002452_abnormal_antigen_presenting0.98488338
95MP0002420_abnormal_adaptive_immunity0.98322531
96MP0008872_abnormal_physiological_respon0.98280416
97MP0003252_abnormal_bile_duct0.97385656
98MP0008995_early_reproductive_senescence0.97055192
99MP0002088_abnormal_embryonic_growth/wei0.96946623
100MP0010234_abnormal_vibrissa_follicle0.96429750
101MP0001819_abnormal_immune_cell0.95555930
102MP0005464_abnormal_platelet_physiology0.94521814
103MP0002277_abnormal_respiratory_mucosa0.93387170
104MP0002653_abnormal_ependyma_morphology0.93227496
105MP0005266_abnormal_metabolism0.92994651
106MP0003718_maternal_effect0.92000418
107MP0002723_abnormal_immune_serum0.91754338
108MP0003136_yellow_coat_color0.91294511
109MP0002148_abnormal_hypersensitivity_rea0.90786385
110MP0009785_altered_susceptibility_to0.90104683
111MP0001119_abnormal_female_reproductive0.88904409
112MP0001879_abnormal_lymphatic_vessel0.88424104
113MP0003878_abnormal_ear_physiology0.87896577
114MP0005377_hearing/vestibular/ear_phenot0.87896577
115MP0000371_diluted_coat_color0.86256311
116MP0005389_reproductive_system_phenotype0.86060448
117MP0002086_abnormal_extraembryonic_tissu0.85589728
118MP0005408_hypopigmentation0.84623978
119MP0000358_abnormal_cell_content/0.84617488
120MP0001986_abnormal_taste_sensitivity0.84536717
121MP0005645_abnormal_hypothalamus_physiol0.84248355
122MP0001324_abnormal_eye_pigmentation0.84107310
123MP0000647_abnormal_sebaceous_gland0.83709110
124MP0010030_abnormal_orbit_morphology0.83194186
125MP0001501_abnormal_sleep_pattern0.82496576
126MP0005379_endocrine/exocrine_gland_phen0.81693678
127MP0004134_abnormal_chest_morphology0.81677098
128MP0003567_abnormal_fetal_cardiomyocyte0.81492594
129MP0002090_abnormal_vision0.80690448
130MP0002938_white_spotting0.80116711
131MP0004084_abnormal_cardiac_muscle0.80116404
132MP0005636_abnormal_mineral_homeostasis0.79855370
133MP0006082_CNS_inflammation0.79810960
134MP0005395_other_phenotype0.79043430
135MP0005384_cellular_phenotype0.78208706
136MP0004197_abnormal_fetal_growth/weight/0.78123588
137MP0002166_altered_tumor_susceptibility0.78005207
138MP0006276_abnormal_autonomic_nervous0.76873910
139MP0005621_abnormal_cell_physiology0.75045120
140MP0001919_abnormal_reproductive_system0.74434643
141MP0009764_decreased_sensitivity_to0.74386220
142MP0000465_gastrointestinal_hemorrhage0.73340097
143MP0002160_abnormal_reproductive_system0.72578039
144MP0002332_abnormal_exercise_endurance0.72033887
145MP0002006_tumorigenesis0.71761735
146MP0002098_abnormal_vibrissa_morphology0.70562093
147MP0003698_abnormal_male_reproductive0.69191137
148MP0000858_altered_metastatic_potential0.67771074
149MP0005000_abnormal_immune_tolerance0.66332600
150MP0002075_abnormal_coat/hair_pigmentati0.65770012
151MP0003011_delayed_dark_adaptation0.65703731
152MP0002751_abnormal_autonomic_nervous0.65415801
153MP0006072_abnormal_retinal_apoptosis0.65227091
154MP0002405_respiratory_system_inflammati0.63795104
155MP0005220_abnormal_exocrine_pancreas0.63396634
156MP0001764_abnormal_homeostasis0.62740439
157MP0001186_pigmentation_phenotype0.61480896
158MP0003436_decreased_susceptibility_to0.60616035

Predicted human phenotypes

RankGene SetZ-score
1Aplastic anemia (HP:0001915)4.47828952
2Birth length less than 3rd percentile (HP:0003561)4.22772722
3Dyschromatopsia (HP:0007641)3.99297438
4Reticulocytopenia (HP:0001896)3.95840919
5Rough bone trabeculation (HP:0100670)3.74057096
6Premature graying of hair (HP:0002216)3.39728556
7Abnormality of cells of the erythroid lineage (HP:0012130)3.35533986
8Breast hypoplasia (HP:0003187)3.20390261
9Poikiloderma (HP:0001029)3.19946212
10Chromsome breakage (HP:0040012)3.18602866
11Central scotoma (HP:0000603)3.17995394
12Abnormal number of erythroid precursors (HP:0012131)3.17195202
13Severe visual impairment (HP:0001141)3.14015814
14Cerebral hypomyelination (HP:0006808)3.05320833
15Entropion (HP:0000621)3.01810306
16Abnormality of the renal cortex (HP:0011035)3.00365700
17Methylmalonic acidemia (HP:0002912)2.94225294
18Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92445206
19Degeneration of anterior horn cells (HP:0002398)2.89398227
20Abnormality of the anterior horn cell (HP:0006802)2.89398227
21Abolished electroretinogram (ERG) (HP:0000550)2.89310055
22Pallor (HP:0000980)2.78432647
23True hermaphroditism (HP:0010459)2.77544205
24Abnormal trabecular bone morphology (HP:0100671)2.76568616
25Oral leukoplakia (HP:0002745)2.75400187
26Myelodysplasia (HP:0002863)2.74970795
27Increased CSF lactate (HP:0002490)2.74493045
28Abnormality of midbrain morphology (HP:0002418)2.74091633
29Molar tooth sign on MRI (HP:0002419)2.74091633
30IgM deficiency (HP:0002850)2.72723633
31Attenuation of retinal blood vessels (HP:0007843)2.72496886
32Bone marrow hypocellularity (HP:0005528)2.70962295
33Lymphoma (HP:0002665)2.70233857
34Aplasia/Hypoplasia of the uvula (HP:0010293)2.68398657
35Gonadotropin excess (HP:0000837)2.67339621
36Abnormality of methionine metabolism (HP:0010901)2.67077590
37Neoplasm of the pancreas (HP:0002894)2.65872561
38Meckel diverticulum (HP:0002245)2.61915882
39Abnormality of chromosome stability (HP:0003220)2.61247362
40Colon cancer (HP:0003003)2.60910978
41Abnormality of the preputium (HP:0100587)2.58521107
42Macrocytic anemia (HP:0001972)2.58321265
43Abnormality of aspartate family amino acid metabolism (HP:0010899)2.56391690
44Generalized aminoaciduria (HP:0002909)2.53824491
45Carpal bone hypoplasia (HP:0001498)2.53492567
46Granulocytopenia (HP:0001913)2.50089615
47Renal cortical cysts (HP:0000803)2.47850899
48Type I transferrin isoform profile (HP:0003642)2.47332834
49Abnormality of the ileum (HP:0001549)2.47223366
50Methylmalonic aciduria (HP:0012120)2.45706372
51Congenital stationary night blindness (HP:0007642)2.45143875
52Abnormality of DNA repair (HP:0003254)2.43199764
53Medulloblastoma (HP:0002885)2.43164662
54Patellar aplasia (HP:0006443)2.43070722
55Scotoma (HP:0000575)2.42301032
56Freckling (HP:0001480)2.39564042
57Gaze-evoked nystagmus (HP:0000640)2.39229551
58Absent thumb (HP:0009777)2.38138355
59Aplasia/Hypoplasia of the patella (HP:0006498)2.38002349
60Agnosia (HP:0010524)2.37292136
61Duplicated collecting system (HP:0000081)2.35561015
62Sensory axonal neuropathy (HP:0003390)2.35462269
63Panhypogammaglobulinemia (HP:0003139)2.35288569
64Bile duct proliferation (HP:0001408)2.33988344
65Abnormal biliary tract physiology (HP:0012439)2.33988344
66Abnormality of serum amino acid levels (HP:0003112)2.32875045
67Congenital, generalized hypertrichosis (HP:0004540)2.31968937
68Abnormality of vitamin B metabolism (HP:0004340)2.31061761
69Acute encephalopathy (HP:0006846)2.30719748
70Basal cell carcinoma (HP:0002671)2.28691475
71Abnormality of the vitamin B12 metabolism (HP:0004341)2.28690171
72Acute necrotizing encephalopathy (HP:0006965)2.28060899
73Medial flaring of the eyebrow (HP:0010747)2.28037552
74Type 2 muscle fiber atrophy (HP:0003554)2.26098330
75Small intestinal stenosis (HP:0012848)2.25534332
76Duodenal stenosis (HP:0100867)2.25534332
77Abnormality of the renal collecting system (HP:0004742)2.25514824
78Cellulitis (HP:0100658)2.25117854
79Progressive macrocephaly (HP:0004481)2.24940870
80Mitochondrial inheritance (HP:0001427)2.24509637
81Pancytopenia (HP:0001876)2.23682005
82Microretrognathia (HP:0000308)2.22476033
83Cellular immunodeficiency (HP:0005374)2.21563197
84Amaurosis fugax (HP:0100576)2.21299886
85Ectopic kidney (HP:0000086)2.20932802
86Abnormal delayed hypersensitivity skin test (HP:0002963)2.20578454
87Ependymoma (HP:0002888)2.19631278
88Median cleft lip (HP:0000161)2.19484712
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.19461250
90Abnormality of alanine metabolism (HP:0010916)2.19461250
91Hyperalaninemia (HP:0003348)2.19461250
92Muscle fiber atrophy (HP:0100295)2.19360094
93Thrombocytosis (HP:0001894)2.18872403
94Constricted visual fields (HP:0001133)2.18067498
95Abnormality of the heme biosynthetic pathway (HP:0010472)2.13951314
96Eosinophilia (HP:0001880)2.13244314
97Hypothermia (HP:0002045)2.12937956
98Increased serum lactate (HP:0002151)2.12931305
99Aplasia/Hypoplasia of the tibia (HP:0005772)2.12769333
100Stomatitis (HP:0010280)2.12693984
1013-Methylglutaconic aciduria (HP:0003535)2.11326987
102IgG deficiency (HP:0004315)2.10516152
103Aplasia/hypoplasia of the uterus (HP:0008684)2.10321026
104Abnormality of the renal medulla (HP:0100957)2.10292620
105Supernumerary spleens (HP:0009799)2.09364244
106Selective tooth agenesis (HP:0001592)2.09146881
107Horseshoe kidney (HP:0000085)2.08007881
108Premature ovarian failure (HP:0008209)2.07432260
109Nephronophthisis (HP:0000090)2.07331849
110Hypoplasia of the uterus (HP:0000013)2.06589445
111Hepatic necrosis (HP:0002605)2.05460334
112Homocystinuria (HP:0002156)2.04190555
113Abnormality of homocysteine metabolism (HP:0010919)2.04190555
114Impulsivity (HP:0100710)2.03199885
115Abnormal spermatogenesis (HP:0008669)2.02867504
116Microvesicular hepatic steatosis (HP:0001414)1.99971310
117Reduced antithrombin III activity (HP:0001976)1.99859236
118Chronic hepatic failure (HP:0100626)1.99017029
119Abnormal protein glycosylation (HP:0012346)1.96651873
120Abnormal glycosylation (HP:0012345)1.96651873
121Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.96651873
122Abnormal protein N-linked glycosylation (HP:0012347)1.96651873
123CNS hypomyelination (HP:0003429)1.95510322
124Sloping forehead (HP:0000340)1.94946186
125Microcytic anemia (HP:0001935)1.93423655
126Bifid tongue (HP:0010297)1.92463530
127Pendular nystagmus (HP:0012043)1.92262950
128Prominent nose (HP:0000448)1.91085263
129Abnormal rod and cone electroretinograms (HP:0008323)1.89203746
130Lipid accumulation in hepatocytes (HP:0006561)1.88950740
131T lymphocytopenia (HP:0005403)1.88608773
132Abnormality of the duodenum (HP:0002246)1.88533561
133Stomach cancer (HP:0012126)1.88116625
134Progressive inability to walk (HP:0002505)1.87410099
135Clubbing of toes (HP:0100760)1.87238122
136Facial diplegia (HP:0001349)1.86857297
137Abnormality of T cell number (HP:0011839)1.86320392
138Abnormality of B cell number (HP:0010975)1.85790431
139Abnormality of the prostate (HP:0008775)1.85608374
140Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85362572
141Hepatocellular necrosis (HP:0001404)1.84745626
142Absent rod-and cone-mediated responses on ERG (HP:0007688)1.84503664
143Personality changes (HP:0000751)1.84197203
144Absent radius (HP:0003974)1.83099797
145Prostate neoplasm (HP:0100787)1.82981450
146Abnormal number of incisors (HP:0011064)1.82634472
147Increased IgE level (HP:0003212)1.81290016
148Abnormality of eosinophils (HP:0001879)1.80415397
149Triphalangeal thumb (HP:0001199)1.80061303
150Agammaglobulinemia (HP:0004432)1.79879999
151Optic nerve coloboma (HP:0000588)1.79764823
152Increased hepatocellular lipid droplets (HP:0006565)1.79551440
153Secondary amenorrhea (HP:0000869)1.79421121
154Abnormal mitochondria in muscle tissue (HP:0008316)1.78898902
155Abnormality of the columella (HP:0009929)1.78456975
156Abnormality of small intestinal villus morphology (HP:0011472)1.78200120
157Villous atrophy (HP:0011473)1.78200120
158Encephalitis (HP:0002383)1.77816151
159IgA deficiency (HP:0002720)1.77758657
160Pancreatic cysts (HP:0001737)1.77609209
161Decreased central vision (HP:0007663)1.77317145
162Thyroiditis (HP:0100646)1.77160449
163Pancreatic fibrosis (HP:0100732)1.77004280
164Volvulus (HP:0002580)1.76861488
165Small hand (HP:0200055)1.76333456
166Short tibia (HP:0005736)1.75926646
167Glycosuria (HP:0003076)1.75199206
168Abnormality of urine glucose concentration (HP:0011016)1.75199206
169Abnormality of sulfur amino acid metabolism (HP:0004339)1.75055673
170Optic disc pallor (HP:0000543)1.74495836
171Hypoglycemic coma (HP:0001325)1.74046378
172Cerebral edema (HP:0002181)1.73448796
173Hyperglycinemia (HP:0002154)1.72301228
174Hypoproteinemia (HP:0003075)1.72260602
175B lymphocytopenia (HP:0010976)1.71921166
176Lactic acidosis (HP:0003128)1.71714537

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.83279405
2FRK4.52807555
3WEE13.91975281
4BCKDK3.53295578
5ACVR1B3.51794065
6STK163.26070183
7MST43.16692149
8MAP3K122.99053750
9NUAK12.97966335
10BMPR1B2.90421059
11CDC72.72457035
12TAOK32.70989510
13NEK22.55516791
14EIF2AK12.40956761
15PLK42.37326847
16EIF2AK32.25211357
17VRK12.17240767
18WNK32.15552720
19BRSK22.10228388
20TTK2.00724635
21NME21.98675037
22SRPK11.97013407
23TGFBR11.91577348
24DYRK31.86325742
25RPS6KB21.84963828
26PASK1.77443958
27MAP4K21.74341827
28TSSK61.69749523
29OBSCN1.69563620
30PIK3CG1.62337280
31ATR1.62074503
32PINK11.57989372
33PLK11.57098514
34TRIM281.56870049
35EPHA21.55968424
36MKNK11.53941564
37CCNB11.52271680
38MYLK1.52128664
39ADRBK21.51274093
40TLK11.49672246
41ZAK1.49403515
42CDK71.41078430
43AURKB1.39814053
44ERBB31.38674973
45NEK11.35527229
46MAP4K11.31115314
47GRK11.31051265
48KIT1.29951690
49CDK81.29586356
50IRAK31.29284385
51FLT31.28195721
52INSRR1.28171526
53STK101.25638702
54STK31.24986942
55CHEK21.23273971
56OXSR11.16802810
57TESK21.16619301
58MKNK21.07287516
59PAK41.03355724
60BTK1.01553854
61SCYL21.01375306
62PLK31.00779160
63TXK0.99882751
64MUSK0.98753790
65RPS6KA40.98730357
66TYK20.98410719
67NLK0.97632381
68STK38L0.95374626
69CSNK1G10.93739190
70PBK0.93682267
71DYRK20.93616573
72AURKA0.92845015
73CDK120.91871543
74PIM10.90204221
75PIK3CA0.88962248
76IRAK40.87685589
77JAK30.87610604
78ZAP700.86126405
79BRAF0.85595167
80CHEK10.84371999
81BMPR20.83308829
82STK40.81571247
83ATM0.81236383
84STK390.80576652
85CDK40.79592105
86BRSK10.76124120
87MAP3K40.75737077
88LATS10.74745081
89CDK190.73949244
90RPS6KA50.70445618
91PDK20.70097540
92FER0.69250477
93TEC0.68984989
94CSNK1G20.68104585
95ITK0.65846737
96BCR0.63783849
97IRAK10.62698759
98SIK30.61491845
99CSF1R0.60765459
100EEF2K0.60067641
101MAP3K80.58611206
102BLK0.58553102
103TGFBR20.58379402
104PLK20.57444537
105CAMKK20.57355696
106CSNK2A20.57207722
107EIF2AK20.57051774
108CDK20.55040246
109TNIK0.54949535
110PRKCE0.52750173
111IKBKB0.52674891
112PKN20.52094620
113SYK0.51724087
114CSNK1A1L0.50657083
115CSNK2A10.50563743
116BRD40.50560933
117FES0.50391258
118IRAK20.50028222
119PTK2B0.48258867
120PRKCI0.46383136
121ADRBK10.45988673
122MARK30.43476662
123MAP2K30.39672193
124NME10.37874416
125PRKAA20.37354951
126LYN0.37212518
127PRKG10.35955097
128CDK10.35916463
129PRKCQ0.35619403
130FGFR40.34090287
131PAK10.33349764
132AKT30.31866908
133TIE10.31024726
134TAF10.30198343
135KDR0.30104579
136CSNK1G30.29590292
137TAOK20.27927527
138PRKCG0.27868130
139PIM20.27845058
140STK240.27718676
141LRRK20.26758445
142IKBKE0.26130148
143GRK70.25568107
144TNK20.25462765
145LCK0.24517599
146PRKDC0.24110973
147MELK0.23569236
148CHUK0.22835815
149YES10.22463068
150MOS0.21559024
151MAPK150.21129771

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.57273223
2Mismatch repair_Homo sapiens_hsa034303.98201240
3Ribosome_Homo sapiens_hsa030103.36488298
4Spliceosome_Homo sapiens_hsa030403.33659085
5Proteasome_Homo sapiens_hsa030503.28784671
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.26433743
7RNA polymerase_Homo sapiens_hsa030203.11900695
8Nucleotide excision repair_Homo sapiens_hsa034202.94043613
9RNA transport_Homo sapiens_hsa030132.80085095
10Base excision repair_Homo sapiens_hsa034102.77821562
11Homologous recombination_Homo sapiens_hsa034402.71511683
12Cell cycle_Homo sapiens_hsa041102.54428058
13Propanoate metabolism_Homo sapiens_hsa006402.47240130
14Pyrimidine metabolism_Homo sapiens_hsa002402.41637546
15One carbon pool by folate_Homo sapiens_hsa006702.29684587
16Fanconi anemia pathway_Homo sapiens_hsa034602.24784196
17Non-homologous end-joining_Homo sapiens_hsa034502.24223457
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.21753367
19Oxidative phosphorylation_Homo sapiens_hsa001902.07513273
20Basal transcription factors_Homo sapiens_hsa030222.06612550
21RNA degradation_Homo sapiens_hsa030181.98321724
22Protein export_Homo sapiens_hsa030601.98260956
23Asthma_Homo sapiens_hsa053101.67427067
24Parkinsons disease_Homo sapiens_hsa050121.63720405
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.62429869
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53518438
27Butanoate metabolism_Homo sapiens_hsa006501.47905009
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.45832228
29p53 signaling pathway_Homo sapiens_hsa041151.44300938
30Primary immunodeficiency_Homo sapiens_hsa053401.41769271
31Allograft rejection_Homo sapiens_hsa053301.40318531
32mRNA surveillance pathway_Homo sapiens_hsa030151.39227669
33Tryptophan metabolism_Homo sapiens_hsa003801.35209017
34Epstein-Barr virus infection_Homo sapiens_hsa051691.34503054
35Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.32903057
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.31000868
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30386605
38Purine metabolism_Homo sapiens_hsa002301.28596816
39Graft-versus-host disease_Homo sapiens_hsa053321.28021373
40Type I diabetes mellitus_Homo sapiens_hsa049401.24102666
41Antigen processing and presentation_Homo sapiens_hsa046121.24011174
42Autoimmune thyroid disease_Homo sapiens_hsa053201.21959904
43Nitrogen metabolism_Homo sapiens_hsa009101.18411593
44Folate biosynthesis_Homo sapiens_hsa007901.17213058
45Herpes simplex infection_Homo sapiens_hsa051681.14114264
46Caffeine metabolism_Homo sapiens_hsa002321.11133383
47Systemic lupus erythematosus_Homo sapiens_hsa053221.06635405
48Steroid biosynthesis_Homo sapiens_hsa001001.03422288
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.98746286
50Alzheimers disease_Homo sapiens_hsa050100.96941031
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.96714969
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95328040
53Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94772043
54Chemical carcinogenesis_Homo sapiens_hsa052040.92646979
55Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91232511
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90820684
57Pentose phosphate pathway_Homo sapiens_hsa000300.90020111
58Sulfur metabolism_Homo sapiens_hsa009200.89528438
59Primary bile acid biosynthesis_Homo sapiens_hsa001200.89519628
60Viral carcinogenesis_Homo sapiens_hsa052030.87237601
61Olfactory transduction_Homo sapiens_hsa047400.86792916
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.86136340
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.85805694
64Fatty acid elongation_Homo sapiens_hsa000620.84282634
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.81569976
66Selenocompound metabolism_Homo sapiens_hsa004500.80289664
67HTLV-I infection_Homo sapiens_hsa051660.78298399
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77616618
69Ether lipid metabolism_Homo sapiens_hsa005650.74671040
70N-Glycan biosynthesis_Homo sapiens_hsa005100.71967082
71ABC transporters_Homo sapiens_hsa020100.70894969
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.70888316
73beta-Alanine metabolism_Homo sapiens_hsa004100.70339921
74Oocyte meiosis_Homo sapiens_hsa041140.70208442
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69743869
76Linoleic acid metabolism_Homo sapiens_hsa005910.67906470
77Legionellosis_Homo sapiens_hsa051340.67596347
78Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.66877978
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.64812031
80NF-kappa B signaling pathway_Homo sapiens_hsa040640.63818150
81Measles_Homo sapiens_hsa051620.62176586
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61029381
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60546123
84Regulation of autophagy_Homo sapiens_hsa041400.60454810
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60296846
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59221172
87Retinol metabolism_Homo sapiens_hsa008300.58875184
88RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.56341952
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.55773726
90Glutathione metabolism_Homo sapiens_hsa004800.55142449
91Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54111312
92Circadian rhythm_Homo sapiens_hsa047100.52018987
93Apoptosis_Homo sapiens_hsa042100.51734573
94Vitamin digestion and absorption_Homo sapiens_hsa049770.50867918
95Peroxisome_Homo sapiens_hsa041460.50518587
96Other glycan degradation_Homo sapiens_hsa005110.49698214
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.49024086
98B cell receptor signaling pathway_Homo sapiens_hsa046620.48955884
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.48067777
100Staphylococcus aureus infection_Homo sapiens_hsa051500.46759206
101Platelet activation_Homo sapiens_hsa046110.46561702
102Hepatitis B_Homo sapiens_hsa051610.46210264
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.46038734
104Small cell lung cancer_Homo sapiens_hsa052220.45960594
105Hematopoietic cell lineage_Homo sapiens_hsa046400.45026733
106Starch and sucrose metabolism_Homo sapiens_hsa005000.44857885
107Dorso-ventral axis formation_Homo sapiens_hsa043200.44732082
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.44460378
109Taste transduction_Homo sapiens_hsa047420.44405859
110Shigellosis_Homo sapiens_hsa051310.44341901
111alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44193640
112Alcoholism_Homo sapiens_hsa050340.43053095
113Pyruvate metabolism_Homo sapiens_hsa006200.42245875
114Fatty acid degradation_Homo sapiens_hsa000710.41621790
115Thyroid cancer_Homo sapiens_hsa052160.41378459
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.40226003
117Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39987877
118Biosynthesis of amino acids_Homo sapiens_hsa012300.39128404
119Acute myeloid leukemia_Homo sapiens_hsa052210.38257918
120Notch signaling pathway_Homo sapiens_hsa043300.35144973
121Fructose and mannose metabolism_Homo sapiens_hsa000510.33636236
122FoxO signaling pathway_Homo sapiens_hsa040680.32354676
123Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32210272
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.31576445
125Vitamin B6 metabolism_Homo sapiens_hsa007500.30704193
126Galactose metabolism_Homo sapiens_hsa000520.30338281
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.29539904
128Jak-STAT signaling pathway_Homo sapiens_hsa046300.28599834
129Arachidonic acid metabolism_Homo sapiens_hsa005900.27193163
130T cell receptor signaling pathway_Homo sapiens_hsa046600.26603578
131Phototransduction_Homo sapiens_hsa047440.26599299
132MicroRNAs in cancer_Homo sapiens_hsa052060.26459204
133Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24382508
134Pancreatic cancer_Homo sapiens_hsa052120.24257932
135Colorectal cancer_Homo sapiens_hsa052100.24206512
136Influenza A_Homo sapiens_hsa051640.20158242
137Metabolic pathways_Homo sapiens_hsa011000.19345722
138Basal cell carcinoma_Homo sapiens_hsa052170.18613047
139Renin-angiotensin system_Homo sapiens_hsa046140.18286375
140Huntingtons disease_Homo sapiens_hsa050160.17166802
141Leishmaniasis_Homo sapiens_hsa051400.17098126
142Prostate cancer_Homo sapiens_hsa052150.16257662
143Sphingolipid metabolism_Homo sapiens_hsa006000.15744523
144Toll-like receptor signaling pathway_Homo sapiens_hsa046200.15304494
145Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.15008952
146Hedgehog signaling pathway_Homo sapiens_hsa043400.14712642
147Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.14172180
148HIF-1 signaling pathway_Homo sapiens_hsa040660.13811683
149Pathways in cancer_Homo sapiens_hsa052000.13185805
150Tuberculosis_Homo sapiens_hsa051520.11963192

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