METTL2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)6.09156373
2L-fucose catabolic process (GO:0042355)4.27616994
3fucose catabolic process (GO:0019317)4.27616994
4L-fucose metabolic process (GO:0042354)4.27616994
5regulation of nuclear cell cycle DNA replication (GO:0033262)3.76591038
6kynurenine metabolic process (GO:0070189)3.76368936
7pseudouridine synthesis (GO:0001522)3.59958229
8mitochondrial respiratory chain complex I assembly (GO:0032981)3.47789359
9NADH dehydrogenase complex assembly (GO:0010257)3.47789359
10mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.47789359
11DNA deamination (GO:0045006)3.41173503
12indole-containing compound catabolic process (GO:0042436)3.32084812
13indolalkylamine catabolic process (GO:0046218)3.32084812
14tryptophan catabolic process (GO:0006569)3.32084812
15water-soluble vitamin biosynthetic process (GO:0042364)3.30605425
16nonmotile primary cilium assembly (GO:0035058)3.27157190
17protein complex biogenesis (GO:0070271)3.24230736
18regulation of posttranscriptional gene silencing (GO:0060147)3.23730315
19regulation of gene silencing by miRNA (GO:0060964)3.23730315
20regulation of gene silencing by RNA (GO:0060966)3.23730315
21protein-cofactor linkage (GO:0018065)3.23016295
22negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20708132
23negative regulation of translation, ncRNA-mediated (GO:0040033)3.20708132
24regulation of translation, ncRNA-mediated (GO:0045974)3.20708132
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.19006081
26mitochondrial respiratory chain complex assembly (GO:0033108)3.16273107
27detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.14988117
28replication fork processing (GO:0031297)3.14482542
29ATP synthesis coupled proton transport (GO:0015986)3.12704706
30energy coupled proton transport, down electrochemical gradient (GO:0015985)3.12704706
31regulation of hippo signaling (GO:0035330)3.10512203
32indolalkylamine metabolic process (GO:0006586)3.05958197
33cellular ketone body metabolic process (GO:0046950)3.05288263
34reciprocal meiotic recombination (GO:0007131)3.03361794
35reciprocal DNA recombination (GO:0035825)3.03361794
36negative regulation of telomere maintenance (GO:0032205)3.00075559
37kidney morphogenesis (GO:0060993)3.00061172
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.96671008
39respiratory chain complex IV assembly (GO:0008535)2.95869939
40L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.92787056
41maturation of 5.8S rRNA (GO:0000460)2.92659125
42DNA replication checkpoint (GO:0000076)2.88629683
43rRNA catabolic process (GO:0016075)2.87637450
44tryptophan metabolic process (GO:0006568)2.84757488
45meiotic chromosome segregation (GO:0045132)2.80590031
46recombinational repair (GO:0000725)2.80241044
47double-strand break repair via homologous recombination (GO:0000724)2.79304365
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.76278490
49neuronal action potential (GO:0019228)2.74402642
50response to pheromone (GO:0019236)2.71300216
51ketone body metabolic process (GO:1902224)2.70570848
52ubiquinone biosynthetic process (GO:0006744)2.69926304
53neural tube formation (GO:0001841)2.69315767
54sulfation (GO:0051923)2.69096965
55ubiquinone metabolic process (GO:0006743)2.66875454
56detection of light stimulus involved in visual perception (GO:0050908)2.60728920
57detection of light stimulus involved in sensory perception (GO:0050962)2.60728920
58G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57380340
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.55042667
60regulation of mesoderm development (GO:2000380)2.54894204
61signal peptide processing (GO:0006465)2.54208834
62cytochrome complex assembly (GO:0017004)2.53861862
63spinal cord motor neuron differentiation (GO:0021522)2.53233338
64fucosylation (GO:0036065)2.53131706
65peristalsis (GO:0030432)2.50823375
66cornea development in camera-type eye (GO:0061303)2.50534718
67synapsis (GO:0007129)2.50175019
68cellular response to ATP (GO:0071318)2.48811815
69amino acid salvage (GO:0043102)2.48651460
70L-methionine salvage (GO:0071267)2.48651460
71L-methionine biosynthetic process (GO:0071265)2.48651460
72cardiovascular system development (GO:0072358)2.48639893
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48581170
74somatic hypermutation of immunoglobulin genes (GO:0016446)2.48581170
75preassembly of GPI anchor in ER membrane (GO:0016254)2.48525278
76nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48422023
77negative regulation of reactive oxygen species metabolic process (GO:2000378)2.48347765
78protein import into peroxisome matrix (GO:0016558)2.47706238
79peptidyl-histidine modification (GO:0018202)2.47591854
80intracellular protein transmembrane import (GO:0044743)2.46809977
81pyrimidine nucleobase catabolic process (GO:0006208)2.46723988
82epithelial cilium movement (GO:0003351)2.46393209
83cilium morphogenesis (GO:0060271)2.45979758
84* tRNA processing (GO:0008033)2.45241387
85protein K6-linked ubiquitination (GO:0085020)2.43288723
86RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.43066679
87nephron tubule morphogenesis (GO:0072078)2.41455116
88nephron epithelium morphogenesis (GO:0072088)2.41455116
89ncRNA catabolic process (GO:0034661)2.41000819
90exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.39007835
91mitochondrial RNA metabolic process (GO:0000959)2.37881370
92oxidative demethylation (GO:0070989)2.36450227
93maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.35764079
94regulation of action potential (GO:0098900)2.35726738
95indole-containing compound metabolic process (GO:0042430)2.34372790
96negative regulation of mast cell activation (GO:0033004)2.34341833
97histone-serine phosphorylation (GO:0035404)2.34122678
98cilium organization (GO:0044782)2.31492335
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31040201
100regulation of mitotic spindle checkpoint (GO:1903504)2.31040201

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ZNF274_21170338_ChIP-Seq_K562_Hela4.21205632
2VDR_22108803_ChIP-Seq_LS180_Human3.17577046
3GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.12814603
4EZH2_22144423_ChIP-Seq_EOC_Human2.86884676
5* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85219083
6E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.63313812
7GABP_17652178_ChIP-ChIP_JURKAT_Human2.52529743
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.51074041
9GBX2_23144817_ChIP-Seq_PC3_Human2.49977900
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.46167278
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.43075093
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39842890
13* EWS_26573619_Chip-Seq_HEK293_Human2.37286684
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.30778942
15FUS_26573619_Chip-Seq_HEK293_Human2.17942747
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.15788094
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14443344
18NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.04075488
19IRF1_19129219_ChIP-ChIP_H3396_Human2.02036733
20CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96332331
21IGF1R_20145208_ChIP-Seq_DFB_Human1.94392290
22MYC_18940864_ChIP-ChIP_HL60_Human1.93989431
23TAF15_26573619_Chip-Seq_HEK293_Human1.91158151
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.89808692
25RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81595136
26CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80685580
27POU3F2_20337985_ChIP-ChIP_501MEL_Human1.79687935
28ETS1_20019798_ChIP-Seq_JURKAT_Human1.78444498
29CBX2_27304074_Chip-Seq_ESCs_Mouse1.76017666
30FLI1_27457419_Chip-Seq_LIVER_Mouse1.73478071
31JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.72576293
32ER_23166858_ChIP-Seq_MCF-7_Human1.71830394
33MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.61885332
34TP53_22573176_ChIP-Seq_HFKS_Human1.57975363
35P300_19829295_ChIP-Seq_ESCs_Human1.57739852
36FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.55978210
37ELK1_19687146_ChIP-ChIP_HELA_Human1.55433274
38BMI1_23680149_ChIP-Seq_NPCS_Mouse1.54196298
39E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54016547
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.52266860
41VDR_23849224_ChIP-Seq_CD4+_Human1.50003410
42POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33779503
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33779503
44REST_21632747_ChIP-Seq_MESCs_Mouse1.33616978
45* STAT3_23295773_ChIP-Seq_U87_Human1.31405319
46AR_21572438_ChIP-Seq_LNCaP_Human1.31372300
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30230918
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.28501312
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26545680
50CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.24804285
51CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23224617
52RNF2_27304074_Chip-Seq_NSC_Mouse1.21429858
53FOXA1_25329375_ChIP-Seq_VCAP_Human1.19858260
54FOXA1_27270436_Chip-Seq_PROSTATE_Human1.19858260
55UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19164968
56TCF4_23295773_ChIP-Seq_U87_Human1.17910351
57GATA3_21878914_ChIP-Seq_MCF-7_Human1.16737495
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.15596596
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14699495
60GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14670603
61CBP_20019798_ChIP-Seq_JUKART_Human1.14540311
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.14540311
63SRF_21415370_ChIP-Seq_HL-1_Mouse1.12796406
64* HOXB7_26014856_ChIP-Seq_BT474_Human1.12686479
65NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12613308
66BCAT_22108803_ChIP-Seq_LS180_Human1.10340190
67EZH2_27304074_Chip-Seq_ESCs_Mouse1.09261292
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08759852
69AR_25329375_ChIP-Seq_VCAP_Human1.07943990
70NCOR_22424771_ChIP-Seq_293T_Human1.07541328
71NANOG_19829295_ChIP-Seq_ESCs_Human1.05672602
72SOX2_19829295_ChIP-Seq_ESCs_Human1.05672602
73MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05606052
74FOXP3_21729870_ChIP-Seq_TREG_Human1.03514425
75ERA_21632823_ChIP-Seq_H3396_Human1.03311411
76TCF4_22108803_ChIP-Seq_LS180_Human1.01833682
77* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.01216794
78KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01056826
79SMAD4_21799915_ChIP-Seq_A2780_Human0.99795462
80EED_16625203_ChIP-ChIP_MESCs_Mouse0.99321974
81TOP2B_26459242_ChIP-Seq_MCF-7_Human0.97474057
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97169781
83SOX2_16153702_ChIP-ChIP_HESCs_Human0.96862733
84SMAD3_21741376_ChIP-Seq_EPCs_Human0.96665933
85AR_20517297_ChIP-Seq_VCAP_Human0.96606705
86PCGF2_27294783_Chip-Seq_NPCs_Mouse0.95545157
87RUNX2_22187159_ChIP-Seq_PCA_Human0.94138052
88TTF2_22483619_ChIP-Seq_HELA_Human0.93744894
89HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93637091
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91795862
91P53_21459846_ChIP-Seq_SAOS-2_Human0.91182787
92ETV2_25802403_ChIP-Seq_MESCs_Mouse0.90785282
93ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90166715
94PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89504191
95TDRD3_21172665_ChIP-Seq_MCF-7_Human0.88893998
96FOXA1_21572438_ChIP-Seq_LNCaP_Human0.87920523
97* SMAD4_21741376_ChIP-Seq_EPCs_Human0.86230890
98TAF2_19829295_ChIP-Seq_ESCs_Human0.86057650
99FLI1_21867929_ChIP-Seq_TH2_Mouse0.85427933
100CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.85002535

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color2.75195855
2MP0003646_muscle_fatigue2.58025858
3MP0002102_abnormal_ear_morphology2.20260991
4MP0005423_abnormal_somatic_nervous2.15207733
5MP0001968_abnormal_touch/_nociception2.10643039
6MP0005551_abnormal_eye_electrophysiolog2.08519095
7MP0006292_abnormal_olfactory_placode2.07799029
8MP0000569_abnormal_digit_pigmentation2.07546581
9MP0003195_calcinosis2.04037673
10MP0008877_abnormal_DNA_methylation2.00664012
11MP0002938_white_spotting1.98059879
12MP0002653_abnormal_ependyma_morphology1.96958951
13MP0009046_muscle_twitch1.93210635
14MP0003890_abnormal_embryonic-extraembry1.84079473
15MP0004043_abnormal_pH_regulation1.83498535
16MP0004142_abnormal_muscle_tone1.82612071
17MP0002736_abnormal_nociception_after1.81794824
18MP0002638_abnormal_pupillary_reflex1.78949893
19MP0006072_abnormal_retinal_apoptosis1.74429918
20MP0001485_abnormal_pinna_reflex1.72075175
21MP0004147_increased_porphyrin_level1.71621705
22MP0000427_abnormal_hair_cycle1.71524724
23MP0001986_abnormal_taste_sensitivity1.56279586
24MP0004133_heterotaxia1.54774957
25MP0005645_abnormal_hypothalamus_physiol1.54323272
26MP0009745_abnormal_behavioral_response1.53309827
27MP0006276_abnormal_autonomic_nervous1.51623200
28MP0002837_dystrophic_cardiac_calcinosis1.51292523
29MP0005253_abnormal_eye_physiology1.50003010
30MP0008875_abnormal_xenobiotic_pharmacok1.49793710
31MP0004885_abnormal_endolymph1.49777037
32MP0008058_abnormal_DNA_repair1.49660265
33MP0002735_abnormal_chemical_nociception1.49232350
34MP0002272_abnormal_nervous_system1.45973168
35MP0004742_abnormal_vestibular_system1.45617475
36MP0003283_abnormal_digestive_organ1.44931104
37MP0008872_abnormal_physiological_respon1.43727289
38MP0002160_abnormal_reproductive_system1.42412143
39MP0005174_abnormal_tail_pigmentation1.42216305
40MP0003693_abnormal_embryo_hatching1.42215229
41MP0000631_abnormal_neuroendocrine_gland1.41080808
42MP0002234_abnormal_pharynx_morphology1.36904480
43MP0004145_abnormal_muscle_electrophysio1.35949978
44MP0003718_maternal_effect1.34713840
45MP0002876_abnormal_thyroid_physiology1.34497599
46MP0003937_abnormal_limbs/digits/tail_de1.31583008
47MP0009379_abnormal_foot_pigmentation1.28799940
48MP0010094_abnormal_chromosome_stability1.28661006
49MP0000778_abnormal_nervous_system1.27519825
50MP0003119_abnormal_digestive_system1.24695025
51MP0001293_anophthalmia1.23654752
52MP0002928_abnormal_bile_duct1.22077068
53MP0002557_abnormal_social/conspecific_i1.21037447
54MP0005171_absent_coat_pigmentation1.20395637
55MP0002572_abnormal_emotion/affect_behav1.18710516
56MP0001529_abnormal_vocalization1.16573766
57MP0000383_abnormal_hair_follicle1.16138944
58MP0002751_abnormal_autonomic_nervous1.15581623
59MP0002184_abnormal_innervation1.13162623
60MP0005377_hearing/vestibular/ear_phenot1.12513155
61MP0003878_abnormal_ear_physiology1.12513155
62MP0005389_reproductive_system_phenotype1.11763127
63MP0005195_abnormal_posterior_eye1.09839051
64MP0003880_abnormal_central_pattern1.09346487
65MP0003787_abnormal_imprinting1.08825698
66MP0002067_abnormal_sensory_capabilities1.07254939
67MP0005084_abnormal_gallbladder_morpholo1.06813349
68MP0004924_abnormal_behavior1.04560850
69MP0005386_behavior/neurological_phenoty1.04560850
70MP0001486_abnormal_startle_reflex1.03412953
71MP0001970_abnormal_pain_threshold1.03073864
72MP0002064_seizures1.02169285
73MP0000566_synostosis1.01237064
74MP0002063_abnormal_learning/memory/cond1.00987594
75MP0002733_abnormal_thermal_nociception1.00022336
76MP0002752_abnormal_somatic_nervous0.99602637
77MP0005646_abnormal_pituitary_gland0.99155094
78MP0003011_delayed_dark_adaptation0.98957630
79MP0000647_abnormal_sebaceous_gland0.98276009
80MP0000538_abnormal_urinary_bladder0.95723475
81MP0008775_abnormal_heart_ventricle0.94798971
82MP0001919_abnormal_reproductive_system0.94761762
83MP0002210_abnormal_sex_determination0.93603915
84MP0008995_early_reproductive_senescence0.93080149
85MP0000955_abnormal_spinal_cord0.92742566
86MP0005187_abnormal_penis_morphology0.91706808
87MP0002163_abnormal_gland_morphology0.89901372
88MP0005391_vision/eye_phenotype0.88109983
89MP0003635_abnormal_synaptic_transmissio0.86098903
90MP0002095_abnormal_skin_pigmentation0.85664118
91MP0000026_abnormal_inner_ear0.85305028
92MP0002734_abnormal_mechanical_nocicepti0.84405927
93MP0001324_abnormal_eye_pigmentation0.83927655
94MP0004215_abnormal_myocardial_fiber0.82602132
95MP0001501_abnormal_sleep_pattern0.81642546
96MP0000049_abnormal_middle_ear0.79958022
97MP0001286_abnormal_eye_development0.79219009
98MP0000372_irregular_coat_pigmentation0.78926662
99MP0004130_abnormal_muscle_cell0.78524705
100MP0008057_abnormal_DNA_replication0.77939656

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.41018704
2Birth length less than 3rd percentile (HP:0003561)4.23312373
3Molar tooth sign on MRI (HP:0002419)4.13792319
4Abnormality of midbrain morphology (HP:0002418)4.13792319
5Pancreatic fibrosis (HP:0100732)4.03577452
6True hermaphroditism (HP:0010459)3.76539868
7Congenital stationary night blindness (HP:0007642)3.56256561
8Abnormality of alanine metabolism (HP:0010916)3.53862831
9Hyperalaninemia (HP:0003348)3.53862831
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.53862831
11Nephronophthisis (HP:0000090)3.44983092
12Patellar aplasia (HP:0006443)3.20244927
13Type II lissencephaly (HP:0007260)3.04709248
14Aplasia/Hypoplasia of the patella (HP:0006498)3.00905763
15Tubular atrophy (HP:0000092)2.99706202
16Hyperventilation (HP:0002883)2.98244317
17Abnormality of the renal cortex (HP:0011035)2.91158310
18Abnormality of the renal medulla (HP:0100957)2.91150704
19Pendular nystagmus (HP:0012043)2.85999107
20Genetic anticipation (HP:0003743)2.67560094
21Inability to walk (HP:0002540)2.65489299
22Cystic liver disease (HP:0006706)2.64639735
23Medial flaring of the eyebrow (HP:0010747)2.63552006
24Attenuation of retinal blood vessels (HP:0007843)2.59873092
25Abnormality of the pons (HP:0007361)2.53001164
26Sclerocornea (HP:0000647)2.52443443
27Abnormal number of erythroid precursors (HP:0012131)2.49003968
28Chronic hepatic failure (HP:0100626)2.48211899
29Lissencephaly (HP:0001339)2.48125606
30Large for gestational age (HP:0001520)2.45762194
31Progressive inability to walk (HP:0002505)2.44558394
32Hypoplasia of the pons (HP:0012110)2.44252656
33Cerebellar dysplasia (HP:0007033)2.41070055
34Protruding tongue (HP:0010808)2.36898785
35Concave nail (HP:0001598)2.33548785
36Abnormal drinking behavior (HP:0030082)2.33353174
37Polydipsia (HP:0001959)2.33353174
38Gait imbalance (HP:0002141)2.29494894
39Abnormality of cells of the erythroid lineage (HP:0012130)2.29041148
40Chorioretinal atrophy (HP:0000533)2.27200756
41Anencephaly (HP:0002323)2.24927009
42Breast hypoplasia (HP:0003187)2.21842919
43Abolished electroretinogram (ERG) (HP:0000550)2.19954567
44Congenital primary aphakia (HP:0007707)2.18495502
45Aplasia/Hypoplasia of the uvula (HP:0010293)2.18043328
46Furrowed tongue (HP:0000221)2.14610465
47Duplicated collecting system (HP:0000081)2.13247539
48Rib fusion (HP:0000902)2.12774053
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.12573419
50Congenital, generalized hypertrichosis (HP:0004540)2.11368190
51Abnormality of the renal collecting system (HP:0004742)2.08756514
52Partial agenesis of the corpus callosum (HP:0001338)2.05522399
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.03881605
54Absent thumb (HP:0009777)2.02624029
55Abnormality of the ileum (HP:0001549)2.00597219
56Nephrogenic diabetes insipidus (HP:0009806)1.99033738
57Dynein arm defect of respiratory motile cilia (HP:0012255)1.98926002
58Absent/shortened dynein arms (HP:0200106)1.98926002
59Progressive cerebellar ataxia (HP:0002073)1.97154246
60Abnormal biliary tract physiology (HP:0012439)1.96992878
61Bile duct proliferation (HP:0001408)1.96992878
62Severe muscular hypotonia (HP:0006829)1.96639143
63Colon cancer (HP:0003003)1.95131037
64Postaxial foot polydactyly (HP:0001830)1.94961406
65Meckel diverticulum (HP:0002245)1.94900133
66Increased CSF lactate (HP:0002490)1.94058337
67Bilateral microphthalmos (HP:0007633)1.94047005
68Decreased circulating renin level (HP:0003351)1.93654134
69Congenital hepatic fibrosis (HP:0002612)1.92774564
70Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90172248
71Pachygyria (HP:0001302)1.89656538
72Polyuria (HP:0000103)1.89463707
73Genital tract atresia (HP:0001827)1.87030661
74Increased corneal curvature (HP:0100692)1.86604677
75Keratoconus (HP:0000563)1.86604677
76Preaxial hand polydactyly (HP:0001177)1.86256935
77Dandy-Walker malformation (HP:0001305)1.85788746
78Broad-based gait (HP:0002136)1.84774365
79Abnormality of the carotid arteries (HP:0005344)1.84503108
80Renal cortical cysts (HP:0000803)1.83929031
81Vaginal atresia (HP:0000148)1.83668755
82Anophthalmia (HP:0000528)1.83274006
83Ectopic kidney (HP:0000086)1.82903285
84Abnormal rod and cone electroretinograms (HP:0008323)1.82784645
85Abnormality of the labia minora (HP:0012880)1.82590734
86Gaze-evoked nystagmus (HP:0000640)1.81489075
87Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.80071830
88Tachypnea (HP:0002789)1.79939994
89Bony spicule pigmentary retinopathy (HP:0007737)1.79663316
90Acute necrotizing encephalopathy (HP:0006965)1.79253908
91Poor coordination (HP:0002370)1.78975253
92Optic nerve hypoplasia (HP:0000609)1.77940678
93Chromsome breakage (HP:0040012)1.76110856
94Small hand (HP:0200055)1.75654531
95Lipid accumulation in hepatocytes (HP:0006561)1.75408578
96Increased serum lactate (HP:0002151)1.74062292
97Male pseudohermaphroditism (HP:0000037)1.74054698
98Clumsiness (HP:0002312)1.72981447
99Reticulocytopenia (HP:0001896)1.72873066
100Sloping forehead (HP:0000340)1.72575815

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.96269906
2TLK13.53278626
3ZAK3.49668798
4BMPR1B3.43468857
5ACVR1B3.31689398
6WNK43.20536810
7ADRBK23.14109001
8INSRR2.49284143
9CASK2.35511350
10PNCK2.33398038
11GRK12.01183473
12MKNK22.00565870
13TAOK31.78063567
14WNK31.78018108
15WEE11.62308000
16NUAK11.61463447
17TGFBR11.60731474
18MAPK131.49374201
19PINK11.45487788
20STK391.43479777
21MAP3K41.40768439
22VRK11.40539121
23MAP4K21.40126539
24TSSK61.37517886
25DYRK21.31786121
26MAPK151.29784019
27ADRBK11.27134307
28BRSK21.25840293
29CDC71.23235011
30NEK21.20607198
31DAPK21.19052224
32OXSR11.16086136
33MKNK11.14412992
34CHEK21.10949777
35NME11.10234260
36MARK11.07098383
37MAP2K70.95433453
38PRKCG0.94487493
39VRK20.93925402
40PHKG10.90667925
41PHKG20.90667925
42CAMK1D0.87960696
43PLK40.86516950
44MAPKAPK50.85709233
45BUB10.84457416
46SRPK10.83748469
47STK38L0.83607904
48TNIK0.81742840
49RPS6KA50.81575677
50CAMKK20.80139065
51ATR0.77298371
52PLK30.76865197
53TIE10.76172686
54NTRK30.72726349
55MAPKAPK30.71583741
56PIK3CA0.70263099
57TXK0.69299837
58TAF10.68239786
59PLK10.66226036
60PAK30.65156560
61CAMK1G0.64709722
62PRKCE0.62181659
63NTRK20.58659175
64RPS6KA60.52422075
65PKN10.52049234
66CSNK1G20.51448826
67STK160.51143946
68EPHA30.49664938
69CSNK1A1L0.48481552
70CSNK1G10.47160428
71TYRO30.46670173
72SIK20.46154888
73MAP2K60.45434435
74MUSK0.43317148
75PTK2B0.42690961
76CAMK2A0.42476588
77CSNK1G30.42261170
78ATM0.41802855
79OBSCN0.41005333
80PASK0.40024556
81TTK0.39900781
82BCKDK0.39792551
83PRKCI0.39765509
84CAMK10.37810543
85AKT30.37555499
86STK110.36564382
87PRKAA10.34711453
88STK30.34615715
89CHUK0.33234344
90CSNK1A10.33090229
91PRKACA0.32856906
92WNK10.32620680
93AURKB0.32111537
94DYRK30.32023854
95IRAK10.31210234
96PRKCQ0.28318855
97CSNK1E0.27456924
98CDK10.25185064
99CAMKK10.25115521
100MELK0.24386503

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030202.73072854
2Homologous recombination_Homo sapiens_hsa034402.67371513
3Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.59576732
4Nitrogen metabolism_Homo sapiens_hsa009102.58093290
5Oxidative phosphorylation_Homo sapiens_hsa001902.50673471
6Selenocompound metabolism_Homo sapiens_hsa004502.40870711
7Fanconi anemia pathway_Homo sapiens_hsa034602.27345212
8Phototransduction_Homo sapiens_hsa047442.21465801
9Ribosome_Homo sapiens_hsa030102.21274565
10Basal transcription factors_Homo sapiens_hsa030222.20545833
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.19259007
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.06958190
13Sulfur relay system_Homo sapiens_hsa041222.03967403
14Parkinsons disease_Homo sapiens_hsa050121.98946823
15Linoleic acid metabolism_Homo sapiens_hsa005911.97591337
16Butanoate metabolism_Homo sapiens_hsa006501.96731463
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.92337675
18Nicotine addiction_Homo sapiens_hsa050331.91694349
19Protein export_Homo sapiens_hsa030601.83815964
20One carbon pool by folate_Homo sapiens_hsa006701.83215697
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.77525088
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.76506966
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.73779476
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73554182
25Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.68579287
26Huntingtons disease_Homo sapiens_hsa050161.63476923
27Tryptophan metabolism_Homo sapiens_hsa003801.52372588
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.50434186
29RNA degradation_Homo sapiens_hsa030181.50295233
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.42329093
31Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.41219507
32Cardiac muscle contraction_Homo sapiens_hsa042601.36357519
33Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35466730
34Taste transduction_Homo sapiens_hsa047421.35104165
35Pyrimidine metabolism_Homo sapiens_hsa002401.31273544
36Ether lipid metabolism_Homo sapiens_hsa005651.30380512
37Propanoate metabolism_Homo sapiens_hsa006401.27257484
38Alzheimers disease_Homo sapiens_hsa050101.26891326
39Nucleotide excision repair_Homo sapiens_hsa034201.25131623
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16296400
41Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15815666
42Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.13580487
43Caffeine metabolism_Homo sapiens_hsa002321.13383552
44Mismatch repair_Homo sapiens_hsa034301.05651308
45Purine metabolism_Homo sapiens_hsa002301.00796778
46RNA transport_Homo sapiens_hsa030131.00527243
47Morphine addiction_Homo sapiens_hsa050321.00494868
48Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.90375905
49DNA replication_Homo sapiens_hsa030300.87109381
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.86500074
51ABC transporters_Homo sapiens_hsa020100.84191853
52Steroid biosynthesis_Homo sapiens_hsa001000.81916826
53Glutamatergic synapse_Homo sapiens_hsa047240.80988691
54Basal cell carcinoma_Homo sapiens_hsa052170.80928962
55Peroxisome_Homo sapiens_hsa041460.80372130
56Olfactory transduction_Homo sapiens_hsa047400.79413640
57Non-homologous end-joining_Homo sapiens_hsa034500.79282845
58beta-Alanine metabolism_Homo sapiens_hsa004100.76005786
59Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75464309
60GABAergic synapse_Homo sapiens_hsa047270.74878434
61Primary bile acid biosynthesis_Homo sapiens_hsa001200.73413292
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.72555396
63Base excision repair_Homo sapiens_hsa034100.72270056
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71105690
65Glycerolipid metabolism_Homo sapiens_hsa005610.70441458
66Serotonergic synapse_Homo sapiens_hsa047260.69964714
67Metabolic pathways_Homo sapiens_hsa011000.68335478
68Ovarian steroidogenesis_Homo sapiens_hsa049130.68326973
69Proteasome_Homo sapiens_hsa030500.65161512
70Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.62123109
71Insulin secretion_Homo sapiens_hsa049110.62009738
72Lysine degradation_Homo sapiens_hsa003100.61060916
73Chemical carcinogenesis_Homo sapiens_hsa052040.60171812
74Calcium signaling pathway_Homo sapiens_hsa040200.59727134
75Circadian entrainment_Homo sapiens_hsa047130.58743577
76Hedgehog signaling pathway_Homo sapiens_hsa043400.57648419
77Pyruvate metabolism_Homo sapiens_hsa006200.53656512
78Fatty acid biosynthesis_Homo sapiens_hsa000610.53373220
79Sulfur metabolism_Homo sapiens_hsa009200.53038157
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52997262
81Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51768599
82Hippo signaling pathway_Homo sapiens_hsa043900.51450382
83Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50297903
84Retinol metabolism_Homo sapiens_hsa008300.49527580
85Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.48600920
86Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48280273
87Spliceosome_Homo sapiens_hsa030400.47851146
88Arachidonic acid metabolism_Homo sapiens_hsa005900.47522408
89Cell cycle_Homo sapiens_hsa041100.45002426
90Vitamin digestion and absorption_Homo sapiens_hsa049770.44363268
91p53 signaling pathway_Homo sapiens_hsa041150.41346944
92Regulation of autophagy_Homo sapiens_hsa041400.41307409
93Histidine metabolism_Homo sapiens_hsa003400.37477051
94Fat digestion and absorption_Homo sapiens_hsa049750.37303312
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33862617
96Collecting duct acid secretion_Homo sapiens_hsa049660.33605217
97Intestinal immune network for IgA production_Homo sapiens_hsa046720.33272841
98Systemic lupus erythematosus_Homo sapiens_hsa053220.32067319
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32019256
100Alcoholism_Homo sapiens_hsa050340.31983520

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