METTL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.10411587
2ribosome assembly (GO:0042255)5.74297579
3proteasome assembly (GO:0043248)5.49398090
4ribosomal small subunit biogenesis (GO:0042274)5.17537204
5transcription elongation from RNA polymerase III promoter (GO:0006385)4.62810003
6termination of RNA polymerase III transcription (GO:0006386)4.62810003
7deoxyribonucleotide biosynthetic process (GO:0009263)4.61451633
8deoxyribonucleoside diphosphate metabolic process (GO:0009186)4.51782094
9maturation of SSU-rRNA (GO:0030490)4.46177843
10rRNA modification (GO:0000154)4.45811305
11regulation of nuclear cell cycle DNA replication (GO:0033262)4.44266836
12ribonucleoprotein complex biogenesis (GO:0022613)4.40472942
13telomere maintenance via semi-conservative replication (GO:0032201)4.36495679
14ribosomal large subunit biogenesis (GO:0042273)4.32403484
15ribosome biogenesis (GO:0042254)4.22114660
16DNA strand elongation involved in DNA replication (GO:0006271)4.18860754
17DNA damage response, detection of DNA damage (GO:0042769)4.18796907
18mitochondrial DNA replication (GO:0006264)4.18475202
19DNA replication checkpoint (GO:0000076)4.14783992
20spliceosomal snRNP assembly (GO:0000387)4.09176014
21DNA replication initiation (GO:0006270)4.04977895
22deoxyribonucleoside triphosphate metabolic process (GO:0009200)4.01980288
23DNA strand elongation (GO:0022616)3.96781172
24protein-cofactor linkage (GO:0018065)3.94536731
25establishment of integrated proviral latency (GO:0075713)3.93600494
267-methylguanosine mRNA capping (GO:0006370)3.91361836
27replication fork processing (GO:0031297)3.86100916
28DNA ligation (GO:0006266)3.85613997
29RNA capping (GO:0036260)3.83555448
307-methylguanosine RNA capping (GO:0009452)3.83555448
31rRNA processing (GO:0006364)3.80874069
32cullin deneddylation (GO:0010388)3.78561714
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.78557236
34pseudouridine synthesis (GO:0001522)3.78351111
35spliceosomal complex assembly (GO:0000245)3.77488070
36viral transcription (GO:0019083)3.75867111
37telomere maintenance via recombination (GO:0000722)3.73863004
38DNA-dependent DNA replication (GO:0006261)3.69805821
39rRNA metabolic process (GO:0016072)3.69538265
40translational termination (GO:0006415)3.67518712
41positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.66336389
42transcription-coupled nucleotide-excision repair (GO:0006283)3.65285696
43anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.64879361
44tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.63459186
45RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.63459186
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.63141783
47maturation of 5.8S rRNA (GO:0000460)3.62658691
48regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.59896212
49telomere maintenance via telomere lengthening (GO:0010833)3.59886692
50transcription from RNA polymerase I promoter (GO:0006360)3.58316319
51regulation of centriole replication (GO:0046599)3.56892846
52CENP-A containing nucleosome assembly (GO:0034080)3.56562896
53nucleobase biosynthetic process (GO:0046112)3.54846489
54deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.51701788
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.50956597
56L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.49846216
57mitotic metaphase plate congression (GO:0007080)3.48967644
58regulation of mitochondrial translation (GO:0070129)3.48903949
59ribosomal small subunit assembly (GO:0000028)3.48815369
60cellular component biogenesis (GO:0044085)3.48025033
61nucleobase-containing small molecule interconversion (GO:0015949)3.47614117
62DNA topological change (GO:0006265)3.47395427
63negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.46367737
64negative regulation of ligase activity (GO:0051352)3.46367737
65chromatin remodeling at centromere (GO:0031055)3.46316584
66termination of RNA polymerase I transcription (GO:0006363)3.46102089
67histone H4-K12 acetylation (GO:0043983)3.44442651
68transcription elongation from RNA polymerase I promoter (GO:0006362)3.44027426
69purine nucleobase biosynthetic process (GO:0009113)3.43962749
70intra-S DNA damage checkpoint (GO:0031573)3.42529117
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.40944413
72translational initiation (GO:0006413)3.39555121
73IMP biosynthetic process (GO:0006188)3.39335067
74aggressive behavior (GO:0002118)3.39099945
75kinetochore assembly (GO:0051382)3.37404101
76forebrain morphogenesis (GO:0048853)3.36471355
77protein deneddylation (GO:0000338)3.36291626
78mitotic recombination (GO:0006312)3.35708813
79translation (GO:0006412)3.34158583
80signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.33904794
81signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.33904794
82signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.33904794
83DNA double-strand break processing (GO:0000729)3.33881222
84regulation of cellular amino acid metabolic process (GO:0006521)3.33243355
85reciprocal DNA recombination (GO:0035825)3.32924069
86reciprocal meiotic recombination (GO:0007131)3.32924069
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.32498340
88somatic hypermutation of immunoglobulin genes (GO:0016446)3.32495550
89somatic diversification of immune receptors via somatic mutation (GO:0002566)3.32495550
90translational elongation (GO:0006414)3.31477107
91signal transduction involved in DNA integrity checkpoint (GO:0072401)3.29402974
92signal transduction involved in DNA damage checkpoint (GO:0072422)3.29402974
93non-recombinational repair (GO:0000726)3.28939428
94double-strand break repair via nonhomologous end joining (GO:0006303)3.28939428
95maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.28857811
96DNA replication-dependent nucleosome organization (GO:0034723)3.27348137
97rRNA methylation (GO:0031167)3.26716691
98signal transduction involved in cell cycle checkpoint (GO:0072395)3.25349698
99centriole replication (GO:0007099)3.25102507
100amino acid salvage (GO:0043102)3.23107518
101L-methionine salvage (GO:0071267)3.23107518
102L-methionine biosynthetic process (GO:0071265)3.23107518
103regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.21373907
104positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.19230376
105DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17315801
106tRNA methylation (GO:0030488)3.14407562
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14104528
108formation of translation preinitiation complex (GO:0001731)3.13789540
109DNA unwinding involved in DNA replication (GO:0006268)3.13405785
110establishment of protein localization to mitochondrial membrane (GO:0090151)3.13211488
111cotranslational protein targeting to membrane (GO:0006613)3.11556096
112intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.11286418
113signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.11286418
114GMP metabolic process (GO:0046037)3.09608991
115negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)3.08138813
116nucleotide-excision repair, DNA gap filling (GO:0006297)3.07617285
117protein targeting to ER (GO:0045047)3.07317030
118positive regulation of ligase activity (GO:0051351)3.07057995
119mitochondrial DNA metabolic process (GO:0032042)3.05746552
120establishment of viral latency (GO:0019043)3.04680320
121negative regulation of DNA-dependent DNA replication (GO:2000104)3.03954663
122mitochondrial RNA metabolic process (GO:0000959)3.03647293
123DNA replication-dependent nucleosome assembly (GO:0006335)3.02618641
124histone exchange (GO:0043486)3.02479870
125regulation of centrosome duplication (GO:0010824)3.02454899
126histone H2A acetylation (GO:0043968)3.02303976
127DNA replication-independent nucleosome organization (GO:0034724)2.99762752
128DNA replication-independent nucleosome assembly (GO:0006336)2.99762752
129peptidyl-arginine omega-N-methylation (GO:0035247)2.98356291
130viral mRNA export from host cell nucleus (GO:0046784)2.97848317
131kinetochore organization (GO:0051383)2.96741200
132regulation of helicase activity (GO:0051095)2.85628663
133recombinational repair (GO:0000725)2.85610288
134synapsis (GO:0007129)2.85560439
135regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.85560321
136regulation of mitotic spindle checkpoint (GO:1903504)2.85560321
137regulation of cilium movement (GO:0003352)2.83364021
138double-strand break repair via homologous recombination (GO:0000724)2.82868083
139DNA geometric change (GO:0032392)2.81971270
140respiratory chain complex IV assembly (GO:0008535)2.80262228
141mRNA splice site selection (GO:0006376)2.79934105
142ubiquinone biosynthetic process (GO:0006744)2.78703052
143epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.78573678
144peptidyl-arginine methylation (GO:0018216)2.77231907
145peptidyl-arginine N-methylation (GO:0035246)2.77231907
146regulation of centrosome cycle (GO:0046605)2.77005799
147DNA recombination (GO:0006310)2.75934364
148ubiquinone metabolic process (GO:0006743)2.75658204
149iron-sulfur cluster assembly (GO:0016226)2.75570741
150metallo-sulfur cluster assembly (GO:0031163)2.75570741
151snRNA processing (GO:0016180)2.75424670
152IMP metabolic process (GO:0046040)2.74908788
153somatic diversification of immune receptors (GO:0002200)2.74212503
154DNA duplex unwinding (GO:0032508)2.73696251
155histone arginine methylation (GO:0034969)2.72570890
156cytochrome complex assembly (GO:0017004)2.72142538
157negative regulation of DNA recombination (GO:0045910)2.72026630
158V(D)J recombination (GO:0033151)2.71722289
159negative regulation of mRNA processing (GO:0050686)2.71607442
160mismatch repair (GO:0006298)2.71235977
161DNA catabolic process, exonucleolytic (GO:0000738)2.71054590
162meiotic chromosome segregation (GO:0045132)2.70788685
163negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.67027746
164DNA strand renaturation (GO:0000733)2.66648135
165base-excision repair (GO:0006284)2.66217904
166mitotic spindle checkpoint (GO:0071174)2.65325793
167pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.61971208
168somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.60943893

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.81014906
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.57567093
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.47838856
4* GABP_17652178_ChIP-ChIP_JURKAT_Human3.88989979
5* EST1_17652178_ChIP-ChIP_JURKAT_Human3.74191335
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.72069658
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.68084179
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.33792514
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.33197266
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24139967
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23299380
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13188726
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.09559606
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07579981
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.06625716
16CREB1_15753290_ChIP-ChIP_HEK293T_Human3.05434259
17ZNF274_21170338_ChIP-Seq_K562_Hela2.96991546
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.81991116
19* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.64485892
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.62573125
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61539307
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.58935342
23* VDR_23849224_ChIP-Seq_CD4+_Human2.51034446
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.49405333
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.42383196
26* XRN2_22483619_ChIP-Seq_HELA_Human2.41983411
27SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.36221742
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.35780462
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.24175003
30E2F1_18555785_ChIP-Seq_MESCs_Mouse2.23481453
31YY1_21170310_ChIP-Seq_MESCs_Mouse2.21479744
32THAP11_20581084_ChIP-Seq_MESCs_Mouse2.10036227
33* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.08097297
34FUS_26573619_Chip-Seq_HEK293_Human2.07636507
35* TTF2_22483619_ChIP-Seq_HELA_Human2.01788568
36IGF1R_20145208_ChIP-Seq_DFB_Human2.01178709
37* NANOG_18555785_ChIP-Seq_MESCs_Mouse2.00678543
38FOXP3_21729870_ChIP-Seq_TREG_Human1.96980769
39DCP1A_22483619_ChIP-Seq_HELA_Human1.93863302
40MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.90165745
41ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.88525465
42ELK1_19687146_ChIP-ChIP_HELA_Human1.87967675
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87193356
44KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.83747396
45KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.83747396
46KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.83747396
47POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.82228374
48* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81277705
49GABP_19822575_ChIP-Seq_HepG2_Human1.77980173
50EWS_26573619_Chip-Seq_HEK293_Human1.76854188
51* SRF_21415370_ChIP-Seq_HL-1_Mouse1.72625010
52POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70118425
53POU5F1_16153702_ChIP-ChIP_HESCs_Human1.68659035
54VDR_22108803_ChIP-Seq_LS180_Human1.65187701
55* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59377947
56CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.54435847
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54394921
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.53791338
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51527341
60PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50668228
61* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.48145580
62IRF1_19129219_ChIP-ChIP_H3396_Human1.45794503
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.44774760
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40455258
65AR_21909140_ChIP-Seq_LNCAP_Human1.39688247
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38175151
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.38170823
68ELK1_22589737_ChIP-Seq_MCF10A_Human1.37722525
69* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.35780107
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.35383309
71PADI4_21655091_ChIP-ChIP_MCF-7_Human1.33632622
72* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.30951911
73POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27540358
74TAF15_26573619_Chip-Seq_HEK293_Human1.24938807
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23400765
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22982597
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.19693893
78KDM5A_27292631_Chip-Seq_BREAST_Human1.17045553
79* CIITA_25753668_ChIP-Seq_RAJI_Human1.15756747
80* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14995426
81* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.13812989
82TCF3_18692474_ChIP-Seq_MEFs_Mouse1.13346070
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12993104
84TP53_22573176_ChIP-Seq_HFKS_Human1.12930794
85FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12438732
86NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12398591
87MYC_18940864_ChIP-ChIP_HL60_Human1.09837187
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.09211862
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.07627412
90* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.07580560
91SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07186050
92CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06462499
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04246930
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.03153758
95SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.99388493
96CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.98831002
97SOX2_18692474_ChIP-Seq_MEFs_Mouse0.96330635
98SRY_22984422_ChIP-ChIP_TESTIS_Rat0.95899528
99BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94696995
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.93784393
101RBPJ_22232070_ChIP-Seq_NCS_Mouse0.91266461
102SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91192925
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90548481
104DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90402241
105OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90092346
106YY1_22570637_ChIP-Seq_MALME-3M_Human0.89879387
107MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.89829939
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89666324
109PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89271533
110TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89083143
111CTCF_18555785_ChIP-Seq_MESCs_Mouse0.88862405
112* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87267568
113CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.86816048
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.86693592
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.85701543
116CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.84750684
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.83753106
118P300_19829295_ChIP-Seq_ESCs_Human0.83150392
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.83049873
120ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82633452
121KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82508667
122* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82282824
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82153230
124GBX2_23144817_ChIP-Seq_PC3_Human0.81651293
125* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.81563166
126PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79777997
127IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.79696246
128CBP_20019798_ChIP-Seq_JUKART_Human0.79696246
129KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79133599
130HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78515370
131CTBP1_25329375_ChIP-Seq_LNCAP_Human0.76745100
132CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75446826
133CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75203984

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35306251
2MP0003111_abnormal_nucleus_morphology4.43121096
3MP0004957_abnormal_blastocyst_morpholog3.75088485
4MP0008058_abnormal_DNA_repair3.67747437
5MP0010094_abnormal_chromosome_stability3.62987483
6MP0008057_abnormal_DNA_replication3.62939000
7MP0003077_abnormal_cell_cycle3.51421935
8MP0003718_maternal_effect3.31496917
9MP0008932_abnormal_embryonic_tissue3.20908678
10MP0008877_abnormal_DNA_methylation2.69548079
11MP0008007_abnormal_cellular_replicative2.49212522
12MP0009379_abnormal_foot_pigmentation2.46310693
13MP0006292_abnormal_olfactory_placode2.38726734
14MP0003786_premature_aging2.32536011
15MP0002160_abnormal_reproductive_system2.30602207
16MP0003941_abnormal_skin_development2.26462234
17MP0003646_muscle_fatigue2.26404965
18MP0004133_heterotaxia2.21751651
19MP0001188_hyperpigmentation2.06848416
20MP0002938_white_spotting2.05430489
21MP0000566_synostosis2.02626147
22MP0000372_irregular_coat_pigmentation2.00854771
23MP0003136_yellow_coat_color1.97863662
24MP0009697_abnormal_copulation1.96541708
25MP0005389_reproductive_system_phenotype1.95414617
26MP0003315_abnormal_perineum_morphology1.92392029
27MP0001853_heart_inflammation1.80212012
28MP0005394_taste/olfaction_phenotype1.75327480
29MP0005499_abnormal_olfactory_system1.75327480
30MP0003787_abnormal_imprinting1.75275754
31MP0002396_abnormal_hematopoietic_system1.73573265
32MP0003806_abnormal_nucleotide_metabolis1.69198220
33MP0002736_abnormal_nociception_after1.68134668
34MP0003121_genomic_imprinting1.67516339
35MP0002277_abnormal_respiratory_mucosa1.67203580
36MP0001986_abnormal_taste_sensitivity1.64379949
37MP0005409_darkened_coat_color1.60787690
38MP0001730_embryonic_growth_arrest1.60190952
39MP0004381_abnormal_hair_follicle1.58006259
40MP0003123_paternal_imprinting1.54621541
41MP0001764_abnormal_homeostasis1.51410614
42MP0002210_abnormal_sex_determination1.50939856
43MP0003880_abnormal_central_pattern1.50501637
44MP0005220_abnormal_exocrine_pancreas1.50093063
45MP0001984_abnormal_olfaction1.49913768
46MP0001919_abnormal_reproductive_system1.48493967
47MP0002102_abnormal_ear_morphology1.43553150
48MP0001968_abnormal_touch/_nociception1.42675177
49MP0002009_preneoplasia1.40811375
50MP0003122_maternal_imprinting1.38958184
51MP0000350_abnormal_cell_proliferation1.38135813
52MP0001145_abnormal_male_reproductive1.36088087
53MP0005253_abnormal_eye_physiology1.35288933
54MP0005423_abnormal_somatic_nervous1.34732888
55MP0006035_abnormal_mitochondrial_morpho1.33559557
56MP0002928_abnormal_bile_duct1.25252491
57MP0005084_abnormal_gallbladder_morpholo1.24033489
58MP0000313_abnormal_cell_death1.23192310
59MP0003186_abnormal_redox_activity1.22841374
60MP0000631_abnormal_neuroendocrine_gland1.22195430
61MP0002234_abnormal_pharynx_morphology1.21745717
62MP0005395_other_phenotype1.19080607
63MP0000653_abnormal_sex_gland1.15924845
64MP0000613_abnormal_salivary_gland1.15893853
65MP0003119_abnormal_digestive_system1.15532276
66MP0004142_abnormal_muscle_tone1.15160810
67MP0001929_abnormal_gametogenesis1.13979688
68MP0002085_abnormal_embryonic_tissue1.13955296
69MP0005377_hearing/vestibular/ear_phenot1.12252683
70MP0003878_abnormal_ear_physiology1.12252683
71MP0003890_abnormal_embryonic-extraembry1.07845748
72MP0001697_abnormal_embryo_size1.06056119
73MP0001672_abnormal_embryogenesis/_devel1.05796467
74MP0005380_embryogenesis_phenotype1.05796467
75MP0005551_abnormal_eye_electrophysiolog1.05339779
76MP0002111_abnormal_tail_morphology1.04634829
77MP0006276_abnormal_autonomic_nervous1.02380321
78MP0003938_abnormal_ear_development1.02212576
79MP0002080_prenatal_lethality1.01060939
80MP0002282_abnormal_trachea_morphology1.00630971
81MP0008260_abnormal_autophagy1.00544820
82MP0003937_abnormal_limbs/digits/tail_de1.00532732
83MP0004808_abnormal_hematopoietic_stem1.00108841
84MP0001529_abnormal_vocalization0.99327733
85MP0002233_abnormal_nose_morphology0.95437885
86MP0002751_abnormal_autonomic_nervous0.95294529
87MP0004197_abnormal_fetal_growth/weight/0.94642627
88MP0005670_abnormal_white_adipose0.94439114
89MP0008775_abnormal_heart_ventricle0.94428049
90MP0001905_abnormal_dopamine_level0.94177198
91MP0005075_abnormal_melanosome_morpholog0.91808893
92MP0003943_abnormal_hepatobiliary_system0.91546021
93MP0001661_extended_life_span0.90880933
94MP0001727_abnormal_embryo_implantation0.90856489
95MP0009703_decreased_birth_body0.90025852
96MP0003698_abnormal_male_reproductive0.89315239
97MP0000647_abnormal_sebaceous_gland0.88772235
98MP0003936_abnormal_reproductive_system0.88277771
99MP0000516_abnormal_urinary_system0.87969352
100MP0005367_renal/urinary_system_phenotyp0.87969352
101MP0005646_abnormal_pituitary_gland0.87667459
102MP0002132_abnormal_respiratory_system0.87204339
103MP0001485_abnormal_pinna_reflex0.86247092
104MP0001286_abnormal_eye_development0.86017983
105MP0010030_abnormal_orbit_morphology0.82696930
106MP0001293_anophthalmia0.81378206
107MP0010307_abnormal_tumor_latency0.80577895
108MP0006072_abnormal_retinal_apoptosis0.80508181
109MP0003567_abnormal_fetal_cardiomyocyte0.79829256
110MP0000358_abnormal_cell_content/0.79431068
111MP0005391_vision/eye_phenotype0.77193611
112MP0001119_abnormal_female_reproductive0.77176932
113MP0002019_abnormal_tumor_incidence0.77104492
114MP0004043_abnormal_pH_regulation0.76450063
115MP0005384_cellular_phenotype0.74708281
116MP0000049_abnormal_middle_ear0.74462042
117MP0009278_abnormal_bone_marrow0.73037688
118MP0000462_abnormal_digestive_system0.72121158
119MP0008872_abnormal_physiological_respon0.71492771
120MP0000762_abnormal_tongue_morphology0.70024396
121MP0003984_embryonic_growth_retardation0.69921681
122MP0002084_abnormal_developmental_patter0.68198578
123MP0004147_increased_porphyrin_level0.67986858
124MP0002088_abnormal_embryonic_growth/wei0.67124929
125MP0005171_absent_coat_pigmentation0.67123279
126MP0002095_abnormal_skin_pigmentation0.66729804
127MP0005621_abnormal_cell_physiology0.65199135
128MP0009672_abnormal_birth_weight0.64993311
129MP0000703_abnormal_thymus_morphology0.64563353
130MP0002752_abnormal_somatic_nervous0.63872773
131MP0005174_abnormal_tail_pigmentation0.62722462
132MP0008995_early_reproductive_senescence0.62267240
133MP0000678_abnormal_parathyroid_gland0.61819965
134MP0006036_abnormal_mitochondrial_physio0.61792522
135MP0009333_abnormal_splenocyte_physiolog0.60830729
136MP0005266_abnormal_metabolism0.60676585
137MP0003861_abnormal_nervous_system0.58748562
138MP0002161_abnormal_fertility/fecundity0.56596268
139MP0000490_abnormal_crypts_of0.56472614
140MP0002653_abnormal_ependyma_morphology0.53184238
141MP0002114_abnormal_axial_skeleton0.52125633
142MP0008789_abnormal_olfactory_epithelium0.51741043
143MP0000858_altered_metastatic_potential0.51477123

Predicted human phenotypes

RankGene SetZ-score
1Progressive external ophthalmoplegia (HP:0000590)6.72669879
2Breast hypoplasia (HP:0003187)5.39231046
3Muscle abnormality related to mitochondrial dysfunction (HP:0003800)5.06637055
4Birth length less than 3rd percentile (HP:0003561)4.81674627
5Cerebral hypomyelination (HP:0006808)4.17959388
6Reticulocytopenia (HP:0001896)4.01801152
7Carpal bone hypoplasia (HP:0001498)3.78512475
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.77150710
9Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.74845338
10Panhypogammaglobulinemia (HP:0003139)3.72371622
11External ophthalmoplegia (HP:0000544)3.57743545
12Duplicated collecting system (HP:0000081)3.49272374
13Chromsome breakage (HP:0040012)3.46700363
14Absent radius (HP:0003974)3.38528254
15Macrocytic anemia (HP:0001972)3.29826568
16Hyperglycinemia (HP:0002154)3.28318606
17Absent forearm bone (HP:0003953)3.25972343
18Aplasia involving forearm bones (HP:0009822)3.25972343
19Rhabdomyosarcoma (HP:0002859)3.17079696
20Rough bone trabeculation (HP:0100670)3.15513751
21Granulocytopenia (HP:0001913)3.14561341
22Proximal tubulopathy (HP:0000114)3.12686346
23Aplasia/Hypoplasia of the earlobes (HP:0009906)3.07623373
24Bile duct proliferation (HP:0001408)3.06146226
25Abnormal biliary tract physiology (HP:0012439)3.06146226
26Progressive muscle weakness (HP:0003323)3.04992188
27Meckel diverticulum (HP:0002245)3.04815975
28Abnormality of the renal collecting system (HP:0004742)2.99075785
29Pancreatic cysts (HP:0001737)2.97113867
30Stomach cancer (HP:0012126)2.92394218
31Oral leukoplakia (HP:0002745)2.90572330
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.90419884
33Patellar aplasia (HP:0006443)2.85993566
34Aplasia/Hypoplasia involving the musculature (HP:0001460)2.85435138
35Abnormality of the ileum (HP:0001549)2.83258326
36Aplasia/Hypoplasia of the patella (HP:0006498)2.79087768
37Pancreatic fibrosis (HP:0100732)2.74655057
38Increased serum lactate (HP:0002151)2.73635430
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.73390756
40Abnormality of B cell number (HP:0010975)2.72903675
41True hermaphroditism (HP:0010459)2.70171717
42B lymphocytopenia (HP:0010976)2.69831318
43Medial flaring of the eyebrow (HP:0010747)2.69427990
44Abnormality of the preputium (HP:0100587)2.66173132
45Abnormality of cells of the erythroid lineage (HP:0012130)2.65852121
46Abnormal number of erythroid precursors (HP:0012131)2.61557474
47Acute necrotizing encephalopathy (HP:0006965)2.57743029
48Hyperglycinuria (HP:0003108)2.56120965
49Absent thumb (HP:0009777)2.55427200
503-Methylglutaconic aciduria (HP:0003535)2.54886324
51Severe combined immunodeficiency (HP:0004430)2.54244185
52Exercise intolerance (HP:0003546)2.53160241
53Nephronophthisis (HP:0000090)2.53047770
54Methylmalonic acidemia (HP:0002912)2.52455972
55Aplasia/hypoplasia of the uterus (HP:0008684)2.51742896
56Horseshoe kidney (HP:0000085)2.50301098
57Pallor (HP:0000980)2.46657745
58Abnormality of midbrain morphology (HP:0002418)2.46580918
59Molar tooth sign on MRI (HP:0002419)2.46580918
60Abnormality of glycine metabolism (HP:0010895)2.46386189
61Abnormality of serine family amino acid metabolism (HP:0010894)2.46386189
62Triphalangeal thumb (HP:0001199)2.46302854
63Hepatocellular necrosis (HP:0001404)2.46031261
64Mitochondrial inheritance (HP:0001427)2.44869832
65Congenital primary aphakia (HP:0007707)2.42528698
66Tubulointerstitial nephritis (HP:0001970)2.42046551
67Decreased activity of mitochondrial respiratory chain (HP:0008972)2.41683088
68Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.41683088
69Abnormal trabecular bone morphology (HP:0100671)2.38691285
70CNS hypomyelination (HP:0003429)2.37922513
71Neoplasm of striated muscle (HP:0009728)2.37630020
72Gait imbalance (HP:0002141)2.35337535
73Secondary amenorrhea (HP:0000869)2.33861838
74Aplasia/Hypoplasia of the uvula (HP:0010293)2.31777931
75Supernumerary spleens (HP:0009799)2.28944583
76Premature graying of hair (HP:0002216)2.28898735
77Abnormality of chromosome stability (HP:0003220)2.28365896
78Ependymoma (HP:0002888)2.27823713
79Clubbing of toes (HP:0100760)2.26879943
80Microvesicular hepatic steatosis (HP:0001414)2.24616517
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.24602413
82Abnormal protein N-linked glycosylation (HP:0012347)2.24602413
83Abnormal protein glycosylation (HP:0012346)2.24602413
84Abnormal glycosylation (HP:0012345)2.24602413
85Bone marrow hypocellularity (HP:0005528)2.24061436
86Neoplasm of the pancreas (HP:0002894)2.23881711
87Trismus (HP:0000211)2.23078621
88Sloping forehead (HP:0000340)2.22273633
89Colon cancer (HP:0003003)2.22162174
90Increased CSF lactate (HP:0002490)2.21645226
91Abnormality of glycolysis (HP:0004366)2.18895302
92Increased serum pyruvate (HP:0003542)2.18895302
93Premature ovarian failure (HP:0008209)2.14732764
94Aplastic anemia (HP:0001915)2.14485432
95Increased hepatocellular lipid droplets (HP:0006565)2.14131242
96Squamous cell carcinoma (HP:0002860)2.14060163
97Nephrogenic diabetes insipidus (HP:0009806)2.14001904
98Reduced antithrombin III activity (HP:0001976)2.13725307
99Type I transferrin isoform profile (HP:0003642)2.13676649
100Methylmalonic aciduria (HP:0012120)2.13194517
101Abnormal mitochondria in muscle tissue (HP:0008316)2.12978439
102Impulsivity (HP:0100710)2.12609965
103Breast aplasia (HP:0100783)2.11641782
104Combined immunodeficiency (HP:0005387)2.11366956
105Neoplasm of the adrenal cortex (HP:0100641)2.10167203
106Aplasia/Hypoplasia of the breasts (HP:0010311)2.09385270
107Abolished electroretinogram (ERG) (HP:0000550)2.08144612
108Megaloblastic anemia (HP:0001889)2.08107982
109Duodenal stenosis (HP:0100867)2.07617879
110Small intestinal stenosis (HP:0012848)2.07617879
111Myelodysplasia (HP:0002863)2.07094965
112Cleft eyelid (HP:0000625)2.05738004
113Hepatic necrosis (HP:0002605)2.05204953
114Optic nerve coloboma (HP:0000588)2.04121244
115Abnormality of the renal medulla (HP:0100957)2.03556242
116Lipid accumulation in hepatocytes (HP:0006561)2.03489552
117Postaxial foot polydactyly (HP:0001830)2.03283941
118Renal Fanconi syndrome (HP:0001994)2.03138930
119Microretrognathia (HP:0000308)2.03126303
120Limb hypertonia (HP:0002509)2.03124731
121Sparse eyelashes (HP:0000653)1.99651506
122Abnormality of secondary sexual hair (HP:0009888)1.98903485
123Abnormality of the axillary hair (HP:0100134)1.98903485
124Acute lymphatic leukemia (HP:0006721)1.98645533
125Selective tooth agenesis (HP:0001592)1.97282011
126Abdominal situs inversus (HP:0003363)1.97055070
127Abnormality of abdominal situs (HP:0011620)1.97055070
128Abnormality of the duodenum (HP:0002246)1.96893599
129Cellular immunodeficiency (HP:0005374)1.96462408
130Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.94862583
131Redundant skin (HP:0001582)1.94836637
132Pancytopenia (HP:0001876)1.91817072
133Glucose intolerance (HP:0000833)1.91669469
134Attenuation of retinal blood vessels (HP:0007843)1.91175617
135Fibular aplasia (HP:0002990)1.90723851
136Thyroiditis (HP:0100646)1.90249025
137Hypoproteinemia (HP:0003075)1.90011289
138Unsteady gait (HP:0002317)1.89926294
139Acute encephalopathy (HP:0006846)1.89634364
140Lactic acidosis (HP:0003128)1.89050487
141Vaginal atresia (HP:0000148)1.88630924
142Volvulus (HP:0002580)1.88391391
143Genital tract atresia (HP:0001827)1.88370365
144Congenital stationary night blindness (HP:0007642)1.88146549
145Chronic hepatic failure (HP:0100626)1.88091064
146Cerebellar dysplasia (HP:0007033)1.87176767
147Asplenia (HP:0001746)1.86894401
148Pancreatic islet-cell hyperplasia (HP:0004510)1.86861754
149Abnormality of the labia minora (HP:0012880)1.86296122
150Hypoplasia of the radius (HP:0002984)1.85570374
151Progressive macrocephaly (HP:0004481)1.84985629
152Ureteral duplication (HP:0000073)1.84453761
153Ectopic kidney (HP:0000086)1.83347125
154Delusions (HP:0000746)1.82581195
155Supernumerary bones of the axial skeleton (HP:0009144)1.81893574
156Type 2 muscle fiber atrophy (HP:0003554)1.81348823
157Tracheoesophageal fistula (HP:0002575)1.79435068
158Glioma (HP:0009733)1.79056468
159Preaxial hand polydactyly (HP:0001177)1.78979384
160Congenital hepatic fibrosis (HP:0002612)1.78735108
161Abnormality of methionine metabolism (HP:0010901)1.78602706
162Medulloblastoma (HP:0002885)1.78569830
163Pendular nystagmus (HP:0012043)1.76477072
164Retinal dysplasia (HP:0007973)1.76359188
165Bifid tongue (HP:0010297)1.75975724
166Abnormality of DNA repair (HP:0003254)1.75726755
167Abnormal rod and cone electroretinograms (HP:0008323)1.75049031
168Abnormal lung lobation (HP:0002101)1.74452255
169Optic disc pallor (HP:0000543)1.72106253
170Occipital encephalocele (HP:0002085)1.71946926
171Astigmatism (HP:0000483)1.70871126

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK36.25976164
2PLK45.30406500
3BUB15.02798348
4MARK14.21730117
5STK163.86778026
6ZAK3.65090521
7WEE13.01008565
8IRAK42.96896116
9NUAK12.88467137
10IRAK22.87920463
11EIF2AK12.43615095
12IRAK12.36465990
13SRPK12.36009151
14MAP4K22.26853575
15VRK22.24393442
16PNCK2.19549642
17EPHA22.17379098
18BMPR1B2.16992339
19TTK2.13568496
20CSNK1G12.12626617
21TESK22.08600144
22CDK32.07054535
23TSSK61.90129047
24WNK31.85271721
25FRK1.84233298
26TLK11.73885368
27FLT31.69617031
28EIF2AK31.69317012
29VRK11.62236047
30RPS6KA41.50633480
31CDC71.35982833
32DYRK31.32284285
33MAPK131.32066161
34DYRK1A1.30557768
35PLK31.30107693
36PLK11.29463869
37FGFR21.28542730
38PBK1.28121362
39MAP3K101.20348831
40ERBB31.13233820
41LATS21.12041894
42CDK41.09913498
43TAF11.08929353
44NME10.99434685
45PRKCI0.99162669
46TEC0.98542305
47ATR0.98406473
48TGFBR10.96847153
49DYRK20.95825605
50RPS6KB20.94247009
51CHEK20.92607662
52KDR0.92282982
53MKNK10.92154164
54PAK40.91329492
55CSNK1G20.91255118
56MAP2K70.90606871
57AURKA0.89747707
58MKNK20.87201731
59SGK20.85837199
60EPHA40.85698797
61AKT30.84656853
62CSNK1A1L0.82985702
63CDK80.80372441
64STK38L0.80151081
65CDK90.78062015
66EIF2AK20.77553446
67MAP3K40.76474677
68WNK40.71188757
69CDK70.67502685
70AURKB0.67489880
71BRAF0.66788206
72BRD40.61831159
73CHEK10.58758341
74MAP3K80.58348586
75NEK60.56988508
76TESK10.56985594
77LATS10.55896829
78CAMK2B0.55234154
79BLK0.55080938
80PINK10.52935270
81DAPK10.52732322
82NEK20.52701768
83RPS6KA50.52669981
84NME20.52502559
85STK40.52214488
86PAK10.52066528
87ABL20.51624759
88LIMK10.51059109
89TRIM280.47608132
90TNIK0.46810708
91MAPKAPK30.45117003
92CAMK2G0.44558221
93CSNK2A10.44163458
94CSNK2A20.43147162
95FGFR10.42912584
96BRSK20.42618074
97ITK0.42421348
98CDC42BPA0.42220049
99SGK4940.41619241
100SGK2230.41619241
101ATM0.41062650
102CAMK2D0.39920371
103MAPKAPK50.38675935
104CDK60.36923716
105MAPK70.36720943
106PDK20.36141433
107ARAF0.35953020
108MAP2K40.35946742
109CASK0.35599877
110RPS6KB10.35437537
111BCKDK0.35264773
112INSRR0.35246823
113PRKCQ0.34855012
114CSNK1E0.34801252
115MELK0.34245345
116KIT0.33560368
117MAP3K110.33496993
118NEK10.33362100
119CAMKK20.32657166
120PASK0.32332734
121CDK20.32089333
122PIM20.29665347
123CDK10.29498386
124MST40.26823768
125BRSK10.26536956
126PLK20.26483472
127CDK190.25956826
128MAPK40.25309319
129ADRBK20.23379891
130ACVR1B0.22899672
131PRKDC0.20857923
132ROCK20.18664906
133GRK10.18426675
134NLK0.16081138
135CCNB10.13313735
136STK100.11078403
137CLK10.10291204
138BCR0.08812253
139MAP2K20.08299608
140CSNK1G30.06850973
141MAPK100.06819303
142MAPK90.06748251
143IKBKB0.06000068
144PKN10.05892023
145YES10.05424250
146GSK3B0.02702886

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.55691798
2Proteasome_Homo sapiens_hsa030504.46583911
3Ribosome_Homo sapiens_hsa030104.35252832
4DNA replication_Homo sapiens_hsa030304.26057328
5Mismatch repair_Homo sapiens_hsa034303.64128056
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.60343074
7Spliceosome_Homo sapiens_hsa030403.22012745
8Pyrimidine metabolism_Homo sapiens_hsa002403.07026831
9Fanconi anemia pathway_Homo sapiens_hsa034602.87824425
10Homologous recombination_Homo sapiens_hsa034402.71084918
11Nucleotide excision repair_Homo sapiens_hsa034202.55776705
12RNA transport_Homo sapiens_hsa030132.51074194
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.35660633
14One carbon pool by folate_Homo sapiens_hsa006702.31768430
15Oxidative phosphorylation_Homo sapiens_hsa001902.27539860
16Base excision repair_Homo sapiens_hsa034102.20138801
17Basal transcription factors_Homo sapiens_hsa030221.91106341
18Parkinsons disease_Homo sapiens_hsa050121.90249636
19Cell cycle_Homo sapiens_hsa041101.84204249
20Propanoate metabolism_Homo sapiens_hsa006401.83020086
21Huntingtons disease_Homo sapiens_hsa050161.81830973
22Purine metabolism_Homo sapiens_hsa002301.76569418
23RNA degradation_Homo sapiens_hsa030181.71882775
24Non-homologous end-joining_Homo sapiens_hsa034501.70731783
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55041931
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.54282613
27p53 signaling pathway_Homo sapiens_hsa041151.49269986
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.47354953
29Epstein-Barr virus infection_Homo sapiens_hsa051691.26590505
30Butanoate metabolism_Homo sapiens_hsa006501.24500732
31Glutathione metabolism_Homo sapiens_hsa004801.21403170
32Alzheimers disease_Homo sapiens_hsa050101.17893752
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.16194008
34Protein export_Homo sapiens_hsa030601.12828334
35Vitamin B6 metabolism_Homo sapiens_hsa007501.10388950
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.08992131
37Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.05084930
38Peroxisome_Homo sapiens_hsa041461.00569551
39Folate biosynthesis_Homo sapiens_hsa007901.00104937
40Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97348382
41Lysine degradation_Homo sapiens_hsa003100.95875885
42mRNA surveillance pathway_Homo sapiens_hsa030150.94703969
43Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.94619078
44Phototransduction_Homo sapiens_hsa047440.83798297
45Cyanoamino acid metabolism_Homo sapiens_hsa004600.80624032
46Fatty acid metabolism_Homo sapiens_hsa012120.80298395
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.79760687
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.75914524
49Systemic lupus erythematosus_Homo sapiens_hsa053220.74573083
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71651600
51Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70298724
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69200791
53Pentose phosphate pathway_Homo sapiens_hsa000300.67124553
54Pyruvate metabolism_Homo sapiens_hsa006200.66988428
55Oocyte meiosis_Homo sapiens_hsa041140.64818326
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62696082
57Metabolic pathways_Homo sapiens_hsa011000.62686448
58Arachidonic acid metabolism_Homo sapiens_hsa005900.62477127
59Sphingolipid metabolism_Homo sapiens_hsa006000.57981545
60Transcriptional misregulation in cancer_Homo sapiens_hsa052020.56904387
61Taste transduction_Homo sapiens_hsa047420.56179949
62Intestinal immune network for IgA production_Homo sapiens_hsa046720.56092447
63Biosynthesis of amino acids_Homo sapiens_hsa012300.54201653
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53848455
65Linoleic acid metabolism_Homo sapiens_hsa005910.53178166
66Arginine and proline metabolism_Homo sapiens_hsa003300.51902830
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.50231763
68N-Glycan biosynthesis_Homo sapiens_hsa005100.49746008
69Asthma_Homo sapiens_hsa053100.47337927
70Tryptophan metabolism_Homo sapiens_hsa003800.46569989
71Cardiac muscle contraction_Homo sapiens_hsa042600.44979893
72Phenylalanine metabolism_Homo sapiens_hsa003600.43984579
73Nitrogen metabolism_Homo sapiens_hsa009100.41843743
74Other glycan degradation_Homo sapiens_hsa005110.40239844
75Viral carcinogenesis_Homo sapiens_hsa052030.39839459
76Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37041420
77Ether lipid metabolism_Homo sapiens_hsa005650.36203225
78Regulation of autophagy_Homo sapiens_hsa041400.35606017
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.35112018
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33133041
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.31043411
82Tyrosine metabolism_Homo sapiens_hsa003500.30627133
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.30245636
84Fatty acid degradation_Homo sapiens_hsa000710.29913156
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.29896599
86Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.28672885
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27773685
88Fatty acid elongation_Homo sapiens_hsa000620.27723938
89Sulfur relay system_Homo sapiens_hsa041220.24849632
90Caffeine metabolism_Homo sapiens_hsa002320.24400073
91HTLV-I infection_Homo sapiens_hsa051660.23780385
92Collecting duct acid secretion_Homo sapiens_hsa049660.23631257
93Herpes simplex infection_Homo sapiens_hsa051680.22932720
94Carbon metabolism_Homo sapiens_hsa012000.19680348
95Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19313329
96Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.19311187
97ABC transporters_Homo sapiens_hsa020100.19273957
98Alcoholism_Homo sapiens_hsa050340.18624216
99Hedgehog signaling pathway_Homo sapiens_hsa043400.18573563
100Fructose and mannose metabolism_Homo sapiens_hsa000510.17937914
101Basal cell carcinoma_Homo sapiens_hsa052170.16869786
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.16328443
103Selenocompound metabolism_Homo sapiens_hsa004500.15320067
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.15315416
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.15018498
106Retinol metabolism_Homo sapiens_hsa008300.14620348
107Olfactory transduction_Homo sapiens_hsa047400.14111569
108Glucagon signaling pathway_Homo sapiens_hsa049220.13100851
109Primary bile acid biosynthesis_Homo sapiens_hsa001200.13083665
110Steroid biosynthesis_Homo sapiens_hsa001000.13029036
111Glycerophospholipid metabolism_Homo sapiens_hsa005640.12864411
112beta-Alanine metabolism_Homo sapiens_hsa004100.12860697
113Circadian rhythm_Homo sapiens_hsa047100.10533754
114Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09224775
115Wnt signaling pathway_Homo sapiens_hsa043100.08695030
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.08277333
117Renin-angiotensin system_Homo sapiens_hsa046140.07873699
118Antigen processing and presentation_Homo sapiens_hsa046120.05915614
119Hippo signaling pathway_Homo sapiens_hsa043900.05908905
120Primary immunodeficiency_Homo sapiens_hsa053400.05788222
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.04752648
122Vitamin digestion and absorption_Homo sapiens_hsa049770.02196213
123Tight junction_Homo sapiens_hsa045300.01071500
124Vibrio cholerae infection_Homo sapiens_hsa051100.00689799
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0299746
126Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0269906
127Melanoma_Homo sapiens_hsa05218-0.0265706
128Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550-0.0241929
129Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0167624
130TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0107458

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