

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 6.27860896 |
| 2 | ATP synthesis coupled proton transport (GO:0015986) | 5.51639623 |
| 3 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 5.51639623 |
| 4 | mitochondrial electron transport, NADH to ubiquinone (GO:0006120) | 5.12859750 |
| 5 | chaperone-mediated protein transport (GO:0072321) | 5.12137390 |
| 6 | proteasome assembly (GO:0043248) | 5.11013131 |
| 7 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 5.09463743 |
| 8 | DNA deamination (GO:0045006) | 5.07857795 |
| 9 | ribosomal small subunit assembly (GO:0000028) | 4.88755755 |
| 10 | respiratory electron transport chain (GO:0022904) | 4.61907748 |
| 11 | electron transport chain (GO:0022900) | 4.53682830 |
| 12 | protein neddylation (GO:0045116) | 4.48188291 |
| 13 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.37892152 |
| 14 | purine nucleobase biosynthetic process (GO:0009113) | 4.17128142 |
| 15 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.14342994 |
| 16 | termination of RNA polymerase III transcription (GO:0006386) | 4.14342994 |
| 17 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.10830092 |
| 18 | rRNA modification (GO:0000154) | 4.07972161 |
| 19 | nucleobase biosynthetic process (GO:0046112) | 4.06940161 |
| 20 | maturation of SSU-rRNA (GO:0030490) | 4.04148560 |
| 21 | CENP-A containing nucleosome assembly (GO:0034080) | 3.98544987 |
| 22 | DNA strand elongation (GO:0022616) | 3.97142560 |
| 23 | DNA replication initiation (GO:0006270) | 3.93688238 |
| 24 | telomere maintenance via recombination (GO:0000722) | 3.92807824 |
| 25 | chromatin remodeling at centromere (GO:0031055) | 3.90987105 |
| 26 | pseudouridine synthesis (GO:0001522) | 3.84275835 |
| 27 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.82415156 |
| 28 | ribosomal large subunit biogenesis (GO:0042273) | 3.81653681 |
| 29 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.81465784 |
| 30 | ribosome biogenesis (GO:0042254) | 3.79656356 |
| 31 | regulation of mitochondrial translation (GO:0070129) | 3.76217978 |
| 32 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.76156875 |
| 33 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.75455503 |
| 34 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.73187002 |
| 35 | 7-methylguanosine mRNA capping (GO:0006370) | 3.72651066 |
| 36 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.72317895 |
| 37 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.70979347 |
| 38 | RNA capping (GO:0036260) | 3.68818681 |
| 39 | 7-methylguanosine RNA capping (GO:0009452) | 3.68818681 |
| 40 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.67042783 |
| 41 | protein targeting to mitochondrion (GO:0006626) | 3.66083913 |
| 42 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.64856103 |
| 43 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.60652260 |
| 44 | cytochrome complex assembly (GO:0017004) | 3.58567410 |
| 45 | formation of translation preinitiation complex (GO:0001731) | 3.54493396 |
| 46 | mitotic recombination (GO:0006312) | 3.54139158 |
| 47 | telomere maintenance via telomere lengthening (GO:0010833) | 3.53746631 |
| 48 | ribosomal small subunit biogenesis (GO:0042274) | 3.53466845 |
| 49 | oxidative phosphorylation (GO:0006119) | 3.49704682 |
| 50 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.49110680 |
| 51 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.48916076 |
| 52 | cullin deneddylation (GO:0010388) | 3.47238002 |
| 53 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47104408 |
| 54 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47104408 |
| 55 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47104408 |
| 56 | RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394) | 3.45979888 |
| 57 | tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388) | 3.45979888 |
| 58 | protein localization to mitochondrion (GO:0070585) | 3.45906556 |
| 59 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.45528570 |
| 60 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.45528570 |
| 61 | spliceosomal snRNP assembly (GO:0000387) | 3.45417173 |
| 62 | DNA replication checkpoint (GO:0000076) | 3.45204424 |
| 63 | DNA double-strand break processing (GO:0000729) | 3.44151702 |
| 64 | transcription from RNA polymerase I promoter (GO:0006360) | 3.43477735 |
| 65 | establishment of protein localization to mitochondrion (GO:0072655) | 3.41918269 |
| 66 | maturation of 5.8S rRNA (GO:0000460) | 3.41880615 |
| 67 | negative regulation of ligase activity (GO:0051352) | 3.41536198 |
| 68 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.41536198 |
| 69 | kinetochore organization (GO:0051383) | 3.40167095 |
| 70 | rRNA processing (GO:0006364) | 3.39563014 |
| 71 | cellular component biogenesis (GO:0044085) | 3.39372214 |
| 72 | rRNA methylation (GO:0031167) | 3.38742378 |
| 73 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.38300448 |
| 74 | protein deneddylation (GO:0000338) | 3.37286781 |
| 75 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.36847227 |
| 76 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.36847227 |
| 77 | termination of RNA polymerase I transcription (GO:0006363) | 3.36035306 |
| 78 | water-soluble vitamin biosynthetic process (GO:0042364) | 3.35300646 |
| 79 | kinetochore assembly (GO:0051382) | 3.34401972 |
| 80 | NADH dehydrogenase complex assembly (GO:0010257) | 3.34312214 |
| 81 | mitochondrial respiratory chain complex I biogenesis (GO:0097031) | 3.34312214 |
| 82 | mitochondrial respiratory chain complex I assembly (GO:0032981) | 3.34312214 |
| 83 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.34022107 |
| 84 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.33270464 |
| 85 | protein-cofactor linkage (GO:0018065) | 3.31208702 |
| 86 | rRNA metabolic process (GO:0016072) | 3.30827964 |
| 87 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.28253926 |
| 88 | DNA replication-independent nucleosome organization (GO:0034724) | 3.28253926 |
| 89 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 3.27753569 |
| 90 | DNA damage response, detection of DNA damage (GO:0042769) | 3.24552302 |
| 91 | mitotic metaphase plate congression (GO:0007080) | 3.24370331 |
| 92 | viral transcription (GO:0019083) | 3.23984015 |
| 93 | translation (GO:0006412) | 3.23069807 |
| 94 | 2-deoxyribonucleotide biosynthetic process (GO:0009265) | 3.22480100 |
| 95 | deoxyribose phosphate biosynthetic process (GO:0046385) | 3.22480100 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.19770007 |
| 97 | translational termination (GO:0006415) | 3.19116627 |
| 98 | respiratory chain complex IV assembly (GO:0008535) | 3.18365247 |
| 99 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.17120497 |
| 100 | ATP biosynthetic process (GO:0006754) | 3.16183871 |
| 101 | IMP biosynthetic process (GO:0006188) | 3.15489068 |
| 102 | protein complex biogenesis (GO:0070271) | 3.14148865 |
| 103 | spliceosomal complex assembly (GO:0000245) | 3.14123973 |
| 104 | ribosome assembly (GO:0042255) | 3.13192563 |
| 105 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.09660364 |
| 106 | purine nucleoside triphosphate biosynthetic process (GO:0009145) | 3.08958628 |
| 107 | positive regulation of ligase activity (GO:0051351) | 3.07650070 |
| 108 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.07545539 |
| 109 | antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590) | 3.07408116 |
| 110 | viral life cycle (GO:0019058) | 3.05737897 |
| 111 | peptidyl-histidine modification (GO:0018202) | 3.05317036 |
| 112 | establishment of integrated proviral latency (GO:0075713) | 3.05127299 |
| 113 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.04371910 |
| 114 | cell cycle G1/S phase transition (GO:0044843) | 3.04371910 |
| 115 | histone exchange (GO:0043486) | 3.04230905 |
| 116 | purine ribonucleoside triphosphate biosynthetic process (GO:0009206) | 3.03698061 |
| 117 | cotranslational protein targeting to membrane (GO:0006613) | 3.02412230 |
| 118 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.02170727 |
| 119 | translational elongation (GO:0006414) | 3.01885659 |
| 120 | cellular protein complex disassembly (GO:0043624) | 2.99576013 |
| 121 | viral mRNA export from host cell nucleus (GO:0046784) | 2.98490003 |
| 122 | intracellular protein transmembrane import (GO:0044743) | 2.98416497 |
| 123 | mitochondrial respiratory chain complex assembly (GO:0033108) | 2.97893837 |
| 124 | protein targeting to ER (GO:0045047) | 2.97680118 |
| 125 | L-methionine salvage (GO:0071267) | 2.97060012 |
| 126 | L-methionine biosynthetic process (GO:0071265) | 2.97060012 |
| 127 | amino acid salvage (GO:0043102) | 2.97060012 |
| 128 | deoxyribonucleoside triphosphate metabolic process (GO:0009200) | 2.96377575 |
| 129 | tRNA methylation (GO:0030488) | 2.96299525 |
| 130 | histone mRNA metabolic process (GO:0008334) | 2.95977625 |
| 131 | replication fork processing (GO:0031297) | 2.95545234 |
| 132 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 2.95012626 |
| 133 | translational initiation (GO:0006413) | 2.94867668 |
| 134 | protein localization to endoplasmic reticulum (GO:0070972) | 2.94534835 |
| 135 | DNA catabolic process, exonucleolytic (GO:0000738) | 2.94378481 |
| 136 | mitochondrial transport (GO:0006839) | 2.92980378 |
| 137 | regulation of mitotic spindle checkpoint (GO:1903504) | 2.92662341 |
| 138 | regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266) | 2.92662341 |
| 139 | hydrogen ion transmembrane transport (GO:1902600) | 2.90297152 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.11485971 |
| 2 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.37395967 |
| 3 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.22138025 |
| 4 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.79050398 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.75309254 |
| 6 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.71871721 |
| 7 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.53722505 |
| 8 | ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.38559620 |
| 9 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 3.23170735 |
| 10 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.22951440 |
| 11 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.01440855 |
| 12 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.00903037 |
| 13 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.93203164 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.90078435 |
| 15 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.85785895 |
| 16 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.78241282 |
| 17 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.71831663 |
| 18 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 2.61192648 |
| 19 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.59287821 |
| 20 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.54992899 |
| 21 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.54794596 |
| 22 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.50182437 |
| 23 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.39493123 |
| 24 | FOXP3_21729870_ChIP-Seq_TREG_Human | 2.33422682 |
| 25 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 2.28438028 |
| 26 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.27663210 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.26998532 |
| 28 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.22412365 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.21685297 |
| 30 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.15431027 |
| 31 | * SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 2.14900452 |
| 32 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 2.11751572 |
| 33 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.10176156 |
| 34 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.07852249 |
| 35 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 2.07312922 |
| 36 | GABP_19822575_ChIP-Seq_HepG2_Human | 2.01465934 |
| 37 | VDR_22108803_ChIP-Seq_LS180_Human | 1.95788749 |
| 38 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.91640184 |
| 39 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.90476481 |
| 40 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.83508714 |
| 41 | EWS_26573619_Chip-Seq_HEK293_Human | 1.80727164 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.80655698 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.78275857 |
| 44 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.77457173 |
| 45 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.76099610 |
| 46 | ZNF274_21170338_ChIP-Seq_K562_Hela | 1.75327319 |
| 47 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.74327961 |
| 48 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 1.73111974 |
| 49 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 1.71290059 |
| 50 | * POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.70463067 |
| 51 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.67780349 |
| 52 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.67611073 |
| 53 | FUS_26573619_Chip-Seq_HEK293_Human | 1.66104323 |
| 54 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.59408516 |
| 55 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.56206516 |
| 56 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.49632170 |
| 57 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.47350174 |
| 58 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.44083488 |
| 59 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.43891903 |
| 60 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.42993553 |
| 61 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.41059230 |
| 62 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.34688481 |
| 63 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.33123007 |
| 64 | FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse | 1.32394149 |
| 65 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.32010540 |
| 66 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.31112736 |
| 67 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.31053338 |
| 68 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.27921958 |
| 69 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.26816841 |
| 70 | IRF8_22096565_ChIP-ChIP_GC-B_Mouse | 1.24944726 |
| 71 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.23620546 |
| 72 | ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.22480087 |
| 73 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.21858534 |
| 74 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.20706238 |
| 75 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.18364832 |
| 76 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.17938749 |
| 77 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 1.15521254 |
| 78 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.14212445 |
| 79 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.14085909 |
| 80 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.12397985 |
| 81 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.10840049 |
| 82 | * KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.07737750 |
| 83 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 1.07292800 |
| 84 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.06231883 |
| 85 | ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.06121082 |
| 86 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 1.04753663 |
| 87 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04425361 |
| 88 | TP53_22573176_ChIP-Seq_HFKS_Human | 1.03922806 |
| 89 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.03320803 |
| 90 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 1.02583751 |
| 91 | SPI1_23547873_ChIP-Seq_NB4_Human | 1.00343953 |
| 92 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.00210018 |
| 93 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.99278517 |
| 94 | P300_19829295_ChIP-Seq_ESCs_Human | 0.98616271 |
| 95 | EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human | 0.98547577 |
| 96 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 0.98241617 |
| 97 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.96093194 |
| 98 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.95881272 |
| 99 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 0.94966630 |
| 100 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.93883684 |
| 101 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.93826493 |
| 102 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.93401889 |
| 103 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 0.89091067 |
| 104 | RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse | 0.88765000 |
| 105 | GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse | 0.86427615 |
| 106 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 0.84348690 |
| 107 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 0.83708089 |
| 108 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 0.82449021 |
| 109 | SOX2_19829295_ChIP-Seq_ESCs_Human | 0.82257530 |
| 110 | NANOG_19829295_ChIP-Seq_ESCs_Human | 0.82257530 |
| 111 | FOXA1_25329375_ChIP-Seq_VCAP_Human | 0.81458556 |
| 112 | FOXA1_27270436_Chip-Seq_PROSTATE_Human | 0.81458556 |
| 113 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.80961620 |
| 114 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 0.80859499 |
| 115 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 0.78592814 |
| 116 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.76976004 |
| 117 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 0.76667352 |
| 118 | * KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 0.76572699 |
| 119 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.75170688 |
| 120 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 0.73746298 |
| 121 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.73422819 |
| 122 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.73171079 |
| 123 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 0.70707787 |
| 124 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 0.69527066 |
| 125 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.68242573 |
| 126 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.66160383 |
| 127 | KAP1_22055183_ChIP-Seq_ESCs_Mouse | 0.64400006 |
| 128 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 0.64124218 |
| 129 | RUNX1_20887958_ChIP-Seq_HPC-7_Mouse | 0.63122842 |
| 130 | GATA1_22383799_ChIP-Seq_G1ME_Mouse | 0.62403499 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.51065344 |
| 2 | MP0004957_abnormal_blastocyst_morpholog | 4.15775670 |
| 3 | MP0010094_abnormal_chromosome_stability | 4.02463637 |
| 4 | MP0008058_abnormal_DNA_repair | 3.91799970 |
| 5 | MP0003111_abnormal_nucleus_morphology | 3.61246534 |
| 6 | MP0008057_abnormal_DNA_replication | 3.45532924 |
| 7 | MP0003077_abnormal_cell_cycle | 3.28767132 |
| 8 | MP0002396_abnormal_hematopoietic_system | 3.20241107 |
| 9 | MP0003806_abnormal_nucleotide_metabolis | 3.08345734 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.75867058 |
| 11 | MP0003186_abnormal_redox_activity | 2.51209547 |
| 12 | MP0008932_abnormal_embryonic_tissue | 2.49263529 |
| 13 | MP0003786_premature_aging | 2.34554776 |
| 14 | MP0002837_dystrophic_cardiac_calcinosis | 2.29973484 |
| 15 | MP0009697_abnormal_copulation | 2.26169581 |
| 16 | MP0005075_abnormal_melanosome_morpholog | 2.21512896 |
| 17 | MP0002132_abnormal_respiratory_system | 2.20184048 |
| 18 | MP0006072_abnormal_retinal_apoptosis | 2.20093187 |
| 19 | MP0003718_maternal_effect | 2.17640689 |
| 20 | MP0006036_abnormal_mitochondrial_physio | 2.07675568 |
| 21 | MP0000490_abnormal_crypts_of | 1.99273698 |
| 22 | MP0008877_abnormal_DNA_methylation | 1.91915621 |
| 23 | MP0002102_abnormal_ear_morphology | 1.91605010 |
| 24 | MP0005084_abnormal_gallbladder_morpholo | 1.87936128 |
| 25 | MP0001293_anophthalmia | 1.82795816 |
| 26 | MP0009379_abnormal_foot_pigmentation | 1.79394261 |
| 27 | MP0001764_abnormal_homeostasis | 1.76686002 |
| 28 | MP0006292_abnormal_olfactory_placode | 1.73038990 |
| 29 | MP0003123_paternal_imprinting | 1.72254050 |
| 30 | MP0001986_abnormal_taste_sensitivity | 1.69271343 |
| 31 | MP0005671_abnormal_response_to | 1.61902361 |
| 32 | MP0003656_abnormal_erythrocyte_physiolo | 1.61206796 |
| 33 | MP0008789_abnormal_olfactory_epithelium | 1.58169763 |
| 34 | MP0003763_abnormal_thymus_physiology | 1.58005596 |
| 35 | MP0002163_abnormal_gland_morphology | 1.54775580 |
| 36 | MP0003880_abnormal_central_pattern | 1.54106891 |
| 37 | MP0003890_abnormal_embryonic-extraembry | 1.51455061 |
| 38 | MP0003941_abnormal_skin_development | 1.49577587 |
| 39 | MP0008995_early_reproductive_senescence | 1.48789588 |
| 40 | MP0002736_abnormal_nociception_after | 1.47486734 |
| 41 | MP0006035_abnormal_mitochondrial_morpho | 1.43661664 |
| 42 | MP0002095_abnormal_skin_pigmentation | 1.43010907 |
| 43 | MP0009333_abnormal_splenocyte_physiolog | 1.41336367 |
| 44 | MP0008260_abnormal_autophagy | 1.40201803 |
| 45 | MP0001835_abnormal_antigen_presentation | 1.38688225 |
| 46 | MP0000350_abnormal_cell_proliferation | 1.36928244 |
| 47 | MP0004147_increased_porphyrin_level | 1.36672471 |
| 48 | MP0004133_heterotaxia | 1.36098444 |
| 49 | MP0003011_delayed_dark_adaptation | 1.35614215 |
| 50 | MP0005397_hematopoietic_system_phenotyp | 1.32934042 |
| 51 | MP0001545_abnormal_hematopoietic_system | 1.32934042 |
| 52 | MP0005253_abnormal_eye_physiology | 1.31758839 |
| 53 | MP0005551_abnormal_eye_electrophysiolog | 1.30794940 |
| 54 | MP0001485_abnormal_pinna_reflex | 1.29967667 |
| 55 | MP0004215_abnormal_myocardial_fiber | 1.29313172 |
| 56 | MP0004145_abnormal_muscle_electrophysio | 1.28231825 |
| 57 | MP0003122_maternal_imprinting | 1.26416567 |
| 58 | MP0001984_abnormal_olfaction | 1.26385488 |
| 59 | MP0003315_abnormal_perineum_morphology | 1.24423160 |
| 60 | MP0005379_endocrine/exocrine_gland_phen | 1.22839761 |
| 61 | MP0000313_abnormal_cell_death | 1.22676978 |
| 62 | MP0001853_heart_inflammation | 1.22108566 |
| 63 | MP0001730_embryonic_growth_arrest | 1.20074080 |
| 64 | MP0002019_abnormal_tumor_incidence | 1.18351572 |
| 65 | MP0002398_abnormal_bone_marrow | 1.17760440 |
| 66 | MP0005646_abnormal_pituitary_gland | 1.17568222 |
| 67 | MP0000631_abnormal_neuroendocrine_gland | 1.17384476 |
| 68 | MP0000689_abnormal_spleen_morphology | 1.13531026 |
| 69 | MP0002160_abnormal_reproductive_system | 1.12999741 |
| 70 | MP0003195_calcinosis | 1.12639390 |
| 71 | MP0005645_abnormal_hypothalamus_physiol | 1.11092678 |
| 72 | MP0005389_reproductive_system_phenotype | 1.10917980 |
| 73 | MP0008872_abnormal_physiological_respon | 1.10651078 |
| 74 | MP0003937_abnormal_limbs/digits/tail_de | 1.10554574 |
| 75 | MP0000647_abnormal_sebaceous_gland | 1.07158144 |
| 76 | MP0002722_abnormal_immune_system | 1.06968874 |
| 77 | MP0009785_altered_susceptibility_to | 1.06549834 |
| 78 | MP0001188_hyperpigmentation | 1.05537008 |
| 79 | MP0010030_abnormal_orbit_morphology | 1.04873846 |
| 80 | MP0005499_abnormal_olfactory_system | 1.04316687 |
| 81 | MP0005394_taste/olfaction_phenotype | 1.04316687 |
| 82 | MP0001286_abnormal_eye_development | 0.99798879 |
| 83 | MP0002210_abnormal_sex_determination | 0.99572475 |
| 84 | MP0006276_abnormal_autonomic_nervous | 0.98455909 |
| 85 | MP0000015_abnormal_ear_pigmentation | 0.98417348 |
| 86 | MP0004808_abnormal_hematopoietic_stem | 0.97158278 |
| 87 | MP0002429_abnormal_blood_cell | 0.96914488 |
| 88 | MP0000703_abnormal_thymus_morphology | 0.96253626 |
| 89 | MP0000465_gastrointestinal_hemorrhage | 0.94498078 |
| 90 | MP0001968_abnormal_touch/_nociception | 0.94267726 |
| 91 | MP0009046_muscle_twitch | 0.93841240 |
| 92 | MP0000372_irregular_coat_pigmentation | 0.93527924 |
| 93 | MP0001119_abnormal_female_reproductive | 0.93248309 |
| 94 | MP0001529_abnormal_vocalization | 0.93061091 |
| 95 | MP0002148_abnormal_hypersensitivity_rea | 0.91332533 |
| 96 | MP0000716_abnormal_immune_system | 0.90466204 |
| 97 | MP0000358_abnormal_cell_content/ | 0.89207219 |
| 98 | MP0002234_abnormal_pharynx_morphology | 0.89085465 |
| 99 | MP0002090_abnormal_vision | 0.88570144 |
| 100 | MP0002233_abnormal_nose_morphology | 0.88079784 |
| 101 | MP0002080_prenatal_lethality | 0.88061285 |
| 102 | MP0003119_abnormal_digestive_system | 0.87673602 |
| 103 | MP0002938_white_spotting | 0.87618810 |
| 104 | MP0002653_abnormal_ependyma_morphology | 0.87199329 |
| 105 | MP0003724_increased_susceptibility_to | 0.86937769 |
| 106 | MP0001145_abnormal_male_reproductive | 0.86931543 |
| 107 | MP0003136_yellow_coat_color | 0.86812529 |
| 108 | MP0001697_abnormal_embryo_size | 0.86507532 |
| 109 | MP0000049_abnormal_middle_ear | 0.85656543 |
| 110 | MP0001929_abnormal_gametogenesis | 0.83007441 |
| 111 | MP0001919_abnormal_reproductive_system | 0.82672989 |
| 112 | MP0002277_abnormal_respiratory_mucosa | 0.82385101 |
| 113 | MP0001800_abnormal_humoral_immune | 0.80862392 |
| 114 | MP0002420_abnormal_adaptive_immunity | 0.80773121 |
| 115 | MP0000653_abnormal_sex_gland | 0.79567394 |
| 116 | MP0005636_abnormal_mineral_homeostasis | 0.79176205 |
| 117 | MP0005408_hypopigmentation | 0.78518278 |
| 118 | MP0001819_abnormal_immune_cell | 0.78476311 |
| 119 | MP0001905_abnormal_dopamine_level | 0.76843168 |
| 120 | MP0008875_abnormal_xenobiotic_pharmacok | 0.76097399 |
| 121 | MP0005391_vision/eye_phenotype | 0.75622402 |
| 122 | MP0001672_abnormal_embryogenesis/_devel | 0.75591586 |
| 123 | MP0005380_embryogenesis_phenotype | 0.75591586 |
| 124 | MP0005266_abnormal_metabolism | 0.74427517 |
| 125 | MP0002723_abnormal_immune_serum | 0.74076801 |
| 126 | MP0005367_renal/urinary_system_phenotyp | 0.73869969 |
| 127 | MP0000516_abnormal_urinary_system | 0.73869969 |
| 128 | MP0002452_abnormal_antigen_presenting | 0.73118958 |
| 129 | MP0002876_abnormal_thyroid_physiology | 0.71489178 |
| 130 | MP0005195_abnormal_posterior_eye | 0.71271970 |
| 131 | MP0002751_abnormal_autonomic_nervous | 0.70135120 |
| 132 | MP0005085_abnormal_gallbladder_physiolo | 0.69095339 |
| 133 | MP0005174_abnormal_tail_pigmentation | 0.68438114 |
| 134 | MP0003137_abnormal_impulse_conducting | 0.68128282 |
| 135 | MP0004142_abnormal_muscle_tone | 0.67254925 |
| 136 | MP0002254_reproductive_system_inflammat | 0.67128191 |
| 137 | MP0005025_abnormal_response_to | 0.67015187 |
| 138 | MP0002638_abnormal_pupillary_reflex | 0.66698464 |
| 139 | MP0008469_abnormal_protein_level | 0.66687435 |
| 140 | MP0005410_abnormal_fertilization | 0.66410200 |
| 141 | MP0003121_genomic_imprinting | 0.66055351 |
| 142 | MP0010307_abnormal_tumor_latency | 0.65915889 |
| 143 | MP0001542_abnormal_bone_strength | 0.65112703 |
| 144 | MP0005464_abnormal_platelet_physiology | 0.63939409 |
| 145 | MP0003866_abnormal_defecation | 0.62497221 |
| 146 | MP0003567_abnormal_fetal_cardiomyocyte | 0.60615154 |
| 147 | MP0001186_pigmentation_phenotype | 0.60442360 |
| 148 | MP0003787_abnormal_imprinting | 0.59876568 |
| 149 | MP0005332_abnormal_amino_acid | 0.59332678 |
| 150 | MP0003984_embryonic_growth_retardation | 0.59279844 |
| 151 | MP0009672_abnormal_birth_weight | 0.58514731 |
| 152 | MP0010352_gastrointestinal_tract_polyps | 0.58395427 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.58114095 |
| 2 | Abnormal number of erythroid precursors (HP:0012131) | 3.98171918 |
| 3 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.92923629 |
| 4 | Acute necrotizing encephalopathy (HP:0006965) | 3.87792752 |
| 5 | Hepatocellular necrosis (HP:0001404) | 3.83441000 |
| 6 | Aplastic anemia (HP:0001915) | 3.81829970 |
| 7 | Mitochondrial inheritance (HP:0001427) | 3.71322582 |
| 8 | Increased CSF lactate (HP:0002490) | 3.69028403 |
| 9 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.65445191 |
| 10 | Hepatic necrosis (HP:0002605) | 3.58133689 |
| 11 | 3-Methylglutaconic aciduria (HP:0003535) | 3.44723578 |
| 12 | Type I transferrin isoform profile (HP:0003642) | 3.44352568 |
| 13 | Reticulocytopenia (HP:0001896) | 3.41677649 |
| 14 | Oral leukoplakia (HP:0002745) | 3.37888465 |
| 15 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.33382974 |
| 16 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.33382974 |
| 17 | Microvesicular hepatic steatosis (HP:0001414) | 3.26760567 |
| 18 | Increased serum lactate (HP:0002151) | 3.24139095 |
| 19 | Acute encephalopathy (HP:0006846) | 3.23118976 |
| 20 | Abnormality of the heme biosynthetic pathway (HP:0010472) | 3.21285604 |
| 21 | Cerebral hypomyelination (HP:0006808) | 3.20340930 |
| 22 | Breast hypoplasia (HP:0003187) | 3.14140116 |
| 23 | Progressive macrocephaly (HP:0004481) | 3.09846123 |
| 24 | Methylmalonic acidemia (HP:0002912) | 3.09040674 |
| 25 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 3.07804655 |
| 26 | Chromsome breakage (HP:0040012) | 3.02634396 |
| 27 | Increased hepatocellular lipid droplets (HP:0006565) | 3.01419179 |
| 28 | Rough bone trabeculation (HP:0100670) | 2.84639080 |
| 29 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.83175617 |
| 30 | Lactic acidosis (HP:0003128) | 2.81617853 |
| 31 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.78528140 |
| 32 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.78300870 |
| 33 | Lipid accumulation in hepatocytes (HP:0006561) | 2.74008954 |
| 34 | Abnormality of the anterior horn cell (HP:0006802) | 2.72911838 |
| 35 | Degeneration of anterior horn cells (HP:0002398) | 2.72911838 |
| 36 | Type 2 muscle fiber atrophy (HP:0003554) | 2.71962144 |
| 37 | Methylmalonic aciduria (HP:0012120) | 2.64497408 |
| 38 | Carpal bone hypoplasia (HP:0001498) | 2.62851260 |
| 39 | Abnormality of the preputium (HP:0100587) | 2.61690814 |
| 40 | Reduced antithrombin III activity (HP:0001976) | 2.58809175 |
| 41 | Macrocytic anemia (HP:0001972) | 2.58407353 |
| 42 | Pallor (HP:0000980) | 2.53009544 |
| 43 | Cerebral edema (HP:0002181) | 2.52120565 |
| 44 | Abnormal protein glycosylation (HP:0012346) | 2.51306581 |
| 45 | Abnormal glycosylation (HP:0012345) | 2.51306581 |
| 46 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.51306581 |
| 47 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.51306581 |
| 48 | Pancreatic cysts (HP:0001737) | 2.50742705 |
| 49 | Pancreatic fibrosis (HP:0100732) | 2.50296061 |
| 50 | Abnormality of renal resorption (HP:0011038) | 2.48225633 |
| 51 | Exercise intolerance (HP:0003546) | 2.47379945 |
| 52 | Optic disc pallor (HP:0000543) | 2.46504313 |
| 53 | Colon cancer (HP:0003003) | 2.44791867 |
| 54 | Molar tooth sign on MRI (HP:0002419) | 2.44550240 |
| 55 | Abnormality of midbrain morphology (HP:0002418) | 2.44550240 |
| 56 | Absent thumb (HP:0009777) | 2.43225349 |
| 57 | Medial flaring of the eyebrow (HP:0010747) | 2.43149217 |
| 58 | Abnormality of chromosome stability (HP:0003220) | 2.42504765 |
| 59 | Pancytopenia (HP:0001876) | 2.41300217 |
| 60 | Premature graying of hair (HP:0002216) | 2.40119285 |
| 61 | Muscle fiber atrophy (HP:0100295) | 2.39618179 |
| 62 | Abnormality of the labia minora (HP:0012880) | 2.39527969 |
| 63 | IgM deficiency (HP:0002850) | 2.37708208 |
| 64 | Respiratory failure (HP:0002878) | 2.37336518 |
| 65 | Sparse eyelashes (HP:0000653) | 2.36735819 |
| 66 | Renal Fanconi syndrome (HP:0001994) | 2.35968918 |
| 67 | True hermaphroditism (HP:0010459) | 2.34287159 |
| 68 | Hyperglycinemia (HP:0002154) | 2.32924455 |
| 69 | Abnormality of urine glucose concentration (HP:0011016) | 2.32762168 |
| 70 | Glycosuria (HP:0003076) | 2.32762168 |
| 71 | CNS demyelination (HP:0007305) | 2.31930094 |
| 72 | Bone marrow hypocellularity (HP:0005528) | 2.29695798 |
| 73 | Increased intramyocellular lipid droplets (HP:0012240) | 2.27213250 |
| 74 | Abnormality of serum amino acid levels (HP:0003112) | 2.23879463 |
| 75 | Meckel diverticulum (HP:0002245) | 2.23749411 |
| 76 | Abnormality of methionine metabolism (HP:0010901) | 2.23266828 |
| 77 | Congenital, generalized hypertrichosis (HP:0004540) | 2.22376486 |
| 78 | Respiratory difficulties (HP:0002880) | 2.21334295 |
| 79 | Myelodysplasia (HP:0002863) | 2.19282314 |
| 80 | Patellar aplasia (HP:0006443) | 2.18239198 |
| 81 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.16744929 |
| 82 | Abnormality of alanine metabolism (HP:0010916) | 2.16744929 |
| 83 | Hyperalaninemia (HP:0003348) | 2.16744929 |
| 84 | Exertional dyspnea (HP:0002875) | 2.15840304 |
| 85 | Abnormality of the ileum (HP:0001549) | 2.12710564 |
| 86 | Aplasia/Hypoplasia of the patella (HP:0006498) | 2.10545448 |
| 87 | Abnormal trabecular bone morphology (HP:0100671) | 2.09012374 |
| 88 | Septo-optic dysplasia (HP:0100842) | 2.04755772 |
| 89 | Nephronophthisis (HP:0000090) | 2.04082561 |
| 90 | Congenital primary aphakia (HP:0007707) | 2.03884425 |
| 91 | Petechiae (HP:0000967) | 2.02300193 |
| 92 | Abnormality of glycolysis (HP:0004366) | 2.02013631 |
| 93 | Increased serum pyruvate (HP:0003542) | 2.02013631 |
| 94 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.01218462 |
| 95 | Thrombocytosis (HP:0001894) | 1.98962588 |
| 96 | Gait imbalance (HP:0002141) | 1.96848487 |
| 97 | Cellular immunodeficiency (HP:0005374) | 1.96703905 |
| 98 | X-linked dominant inheritance (HP:0001423) | 1.96175566 |
| 99 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 1.95923962 |
| 100 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.93907276 |
| 101 | Sclerocornea (HP:0000647) | 1.93688573 |
| 102 | Abnormal spermatogenesis (HP:0008669) | 1.92882474 |
| 103 | Abnormal lung lobation (HP:0002101) | 1.91235036 |
| 104 | Increased muscle lipid content (HP:0009058) | 1.90598812 |
| 105 | Hyperphosphaturia (HP:0003109) | 1.90213913 |
| 106 | CNS hypomyelination (HP:0003429) | 1.89981090 |
| 107 | Generalized aminoaciduria (HP:0002909) | 1.89571682 |
| 108 | Abnormality of pyrimidine metabolism (HP:0004353) | 1.89328247 |
| 109 | Lethargy (HP:0001254) | 1.89154615 |
| 110 | 11 pairs of ribs (HP:0000878) | 1.89108227 |
| 111 | Secondary amenorrhea (HP:0000869) | 1.87726647 |
| 112 | Microretrognathia (HP:0000308) | 1.87566995 |
| 113 | Stenosis of the external auditory canal (HP:0000402) | 1.87521445 |
| 114 | Medulloblastoma (HP:0002885) | 1.87426990 |
| 115 | Nephrogenic diabetes insipidus (HP:0009806) | 1.86621797 |
| 116 | Abnormality of vitamin B metabolism (HP:0004340) | 1.86107855 |
| 117 | Duplicated collecting system (HP:0000081) | 1.84742728 |
| 118 | Triphalangeal thumb (HP:0001199) | 1.82033393 |
| 119 | Leukodystrophy (HP:0002415) | 1.81711292 |
| 120 | Lymphoma (HP:0002665) | 1.81065040 |
| 121 | Dry hair (HP:0011359) | 1.78933148 |
| 122 | Prolonged bleeding time (HP:0003010) | 1.78195443 |
| 123 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.78027409 |
| 124 | Dicarboxylic aciduria (HP:0003215) | 1.78027409 |
| 125 | Poor head control (HP:0002421) | 1.77673356 |
| 126 | Abnormality of the vitamin B12 metabolism (HP:0004341) | 1.77098449 |
| 127 | Genital tract atresia (HP:0001827) | 1.76991250 |
| 128 | Megaloblastic anemia (HP:0001889) | 1.75472470 |
| 129 | Progressive muscle weakness (HP:0003323) | 1.75218496 |
| 130 | Abnormality of the renal collecting system (HP:0004742) | 1.75179228 |
| 131 | Selective tooth agenesis (HP:0001592) | 1.74543138 |
| 132 | Unsteady gait (HP:0002317) | 1.74407040 |
| 133 | Nausea (HP:0002018) | 1.74273737 |
| 134 | Vaginal atresia (HP:0000148) | 1.72051314 |
| 135 | Hypoglycemic coma (HP:0001325) | 1.68902089 |
| 136 | Renal cortical cysts (HP:0000803) | 1.68085456 |
| 137 | Absent septum pellucidum (HP:0001331) | 1.64715381 |
| 138 | Abnormality of homocysteine metabolism (HP:0010919) | 1.63985036 |
| 139 | Homocystinuria (HP:0002156) | 1.63985036 |
| 140 | Median cleft lip (HP:0000161) | 1.63228070 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | STK16 | 4.33441226 |
| 2 | EIF2AK1 | 3.92515164 |
| 3 | BUB1 | 3.82799266 |
| 4 | WEE1 | 3.44669426 |
| 5 | VRK2 | 3.11334038 |
| 6 | SRPK1 | 2.97005985 |
| 7 | EIF2AK3 | 2.87292268 |
| 8 | NME2 | 2.74530559 |
| 9 | VRK1 | 2.43167631 |
| 10 | MAP4K2 | 2.37052268 |
| 11 | TRIM28 | 2.29363275 |
| 12 | BRSK2 | 2.29163557 |
| 13 | TSSK6 | 2.22740270 |
| 14 | WNK3 | 2.21337410 |
| 15 | CDC7 | 2.21260383 |
| 16 | PLK4 | 2.19263182 |
| 17 | MKNK1 | 1.98108898 |
| 18 | MKNK2 | 1.93997592 |
| 19 | ZAK | 1.76417558 |
| 20 | ACVR1B | 1.65575632 |
| 21 | BCKDK | 1.51979086 |
| 22 | FRK | 1.50819778 |
| 23 | NME1 | 1.49023528 |
| 24 | PIM2 | 1.45203965 |
| 25 | AKT3 | 1.44788293 |
| 26 | PLK1 | 1.44547063 |
| 27 | BRSK1 | 1.42621203 |
| 28 | PLK3 | 1.37022659 |
| 29 | TXK | 1.34418108 |
| 30 | TTK | 1.33014506 |
| 31 | BRAF | 1.27484880 |
| 32 | IRAK3 | 1.26820736 |
| 33 | CDK8 | 1.26575947 |
| 34 | EIF2AK2 | 1.25299633 |
| 35 | PBK | 1.23130916 |
| 36 | CCNB1 | 1.22190968 |
| 37 | AURKB | 1.20935014 |
| 38 | CDK7 | 1.18222058 |
| 39 | ATR | 1.17624676 |
| 40 | MUSK | 1.15356395 |
| 41 | BCR | 1.15185869 |
| 42 | PDK2 | 1.12725238 |
| 43 | RPS6KA4 | 1.09708590 |
| 44 | AURKA | 1.09589735 |
| 45 | TEC | 1.08349566 |
| 46 | MAP3K4 | 1.06549131 |
| 47 | DYRK3 | 1.04462368 |
| 48 | NEK2 | 1.03280020 |
| 49 | PASK | 1.03063707 |
| 50 | TLK1 | 1.00930715 |
| 51 | NEK1 | 0.95861265 |
| 52 | IRAK4 | 0.93599248 |
| 53 | FLT3 | 0.91247196 |
| 54 | TAF1 | 0.89799348 |
| 55 | PNCK | 0.89410785 |
| 56 | EPHA2 | 0.88898410 |
| 57 | WNK4 | 0.85684815 |
| 58 | CSNK1G2 | 0.85221059 |
| 59 | RPS6KB2 | 0.85143856 |
| 60 | TESK2 | 0.84687049 |
| 61 | PLK2 | 0.83292347 |
| 62 | LIMK1 | 0.83055533 |
| 63 | CHEK2 | 0.82962522 |
| 64 | CSNK2A1 | 0.80654750 |
| 65 | MST4 | 0.78957563 |
| 66 | PIM1 | 0.77120860 |
| 67 | KIT | 0.76780713 |
| 68 | INSRR | 0.75513065 |
| 69 | CSNK2A2 | 0.75198403 |
| 70 | OXSR1 | 0.74189964 |
| 71 | KDR | 0.73711350 |
| 72 | STK3 | 0.73144661 |
| 73 | YES1 | 0.71382425 |
| 74 | PIK3CG | 0.70833060 |
| 75 | GRK7 | 0.70798244 |
| 76 | STK39 | 0.70240014 |
| 77 | PINK1 | 0.69823325 |
| 78 | MAPK13 | 0.69432477 |
| 79 | MAP4K1 | 0.69391513 |
| 80 | RPS6KA5 | 0.68991686 |
| 81 | ADRBK2 | 0.68766829 |
| 82 | BMPR1B | 0.67814137 |
| 83 | CASK | 0.65776042 |
| 84 | PHKG1 | 0.64256816 |
| 85 | PHKG2 | 0.64256816 |
| 86 | BTK | 0.63645881 |
| 87 | STK24 | 0.61100786 |
| 88 | CSNK1A1L | 0.57517224 |
| 89 | STK4 | 0.57065384 |
| 90 | PRKCG | 0.56992153 |
| 91 | BMPR2 | 0.56538357 |
| 92 | ARAF | 0.56193930 |
| 93 | CHEK1 | 0.54802577 |
| 94 | CSNK1G3 | 0.53910264 |
| 95 | TAOK2 | 0.52784499 |
| 96 | IKBKB | 0.52467337 |
| 97 | ABL2 | 0.52241607 |
| 98 | MAP3K12 | 0.52157741 |
| 99 | CDK19 | 0.51961678 |
| 100 | MAP3K8 | 0.49253288 |
| 101 | MAPK15 | 0.46906137 |
| 102 | ATM | 0.46393971 |
| 103 | CDK3 | 0.45563275 |
| 104 | PRKCE | 0.44925261 |
| 105 | MINK1 | 0.44358162 |
| 106 | GRK1 | 0.43861472 |
| 107 | LYN | 0.43593039 |
| 108 | CSNK1E | 0.43525105 |
| 109 | OBSCN | 0.42859067 |
| 110 | NUAK1 | 0.41243497 |
| 111 | ERBB4 | 0.39931620 |
| 112 | DAPK1 | 0.39810551 |
| 113 | TIE1 | 0.39652164 |
| 114 | DYRK2 | 0.39532973 |
| 115 | TNIK | 0.39302138 |
| 116 | PAK3 | 0.38903544 |
| 117 | CDK4 | 0.38847693 |
| 118 | CDK2 | 0.38722906 |
| 119 | SCYL2 | 0.37732471 |
| 120 | STK38L | 0.37698167 |
| 121 | CSNK1A1 | 0.37383030 |
| 122 | MAP2K7 | 0.37035227 |
| 123 | MAP2K6 | 0.36938793 |
| 124 | PRKCI | 0.36345417 |
| 125 | CSNK1G1 | 0.35410934 |
| 126 | FGFR1 | 0.34680713 |
| 127 | CSF1R | 0.34162807 |
| 128 | NEK9 | 0.33728681 |
| 129 | TGFBR1 | 0.33376381 |
| 130 | MYLK | 0.32396166 |
| 131 | CLK1 | 0.32293673 |
| 132 | ERBB3 | 0.32235917 |
| 133 | NEK6 | 0.32174541 |
| 134 | ZAP70 | 0.32129705 |
| 135 | MAPKAPK5 | 0.31651753 |
| 136 | ADRBK1 | 0.30959352 |
| 137 | PRKACA | 0.26164680 |
| 138 | CAMK2A | 0.26136299 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Proteasome_Homo sapiens_hsa03050 | 4.22671760 |
| 2 | DNA replication_Homo sapiens_hsa03030 | 4.14211543 |
| 3 | RNA polymerase_Homo sapiens_hsa03020 | 3.80463050 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 3.70912697 |
| 5 | Mismatch repair_Homo sapiens_hsa03430 | 3.52531515 |
| 6 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.35862446 |
| 7 | Homologous recombination_Homo sapiens_hsa03440 | 2.97015582 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.75869776 |
| 9 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.67753827 |
| 10 | Spliceosome_Homo sapiens_hsa03040 | 2.62581489 |
| 11 | Base excision repair_Homo sapiens_hsa03410 | 2.57036431 |
| 12 | RNA transport_Homo sapiens_hsa03013 | 2.31565338 |
| 13 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.10588435 |
| 14 | Protein export_Homo sapiens_hsa03060 | 2.09906029 |
| 15 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 2.09368478 |
| 16 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.02342823 |
| 17 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.97503206 |
| 18 | Basal transcription factors_Homo sapiens_hsa03022 | 1.96815699 |
| 19 | Parkinsons disease_Homo sapiens_hsa05012 | 1.95109342 |
| 20 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.94223189 |
| 21 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.84744134 |
| 22 | RNA degradation_Homo sapiens_hsa03018 | 1.74295692 |
| 23 | Cell cycle_Homo sapiens_hsa04110 | 1.68222831 |
| 24 | Folate biosynthesis_Homo sapiens_hsa00790 | 1.64812943 |
| 25 | Purine metabolism_Homo sapiens_hsa00230 | 1.61397157 |
| 26 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.60157576 |
| 27 | Huntingtons disease_Homo sapiens_hsa05016 | 1.59658936 |
| 28 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.50613871 |
| 29 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 1.49235138 |
| 30 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 1.36514003 |
| 31 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 1.23810063 |
| 32 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 1.15750797 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.14594238 |
| 34 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.12006956 |
| 35 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 1.10719079 |
| 36 | Alzheimers disease_Homo sapiens_hsa05010 | 1.09798536 |
| 37 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.09256156 |
| 38 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.07014130 |
| 39 | Selenocompound metabolism_Homo sapiens_hsa00450 | 1.02320917 |
| 40 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.00408593 |
| 41 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.99731982 |
| 42 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.98696264 |
| 43 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.96655151 |
| 44 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.94989172 |
| 45 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.91566508 |
| 46 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 0.90465544 |
| 47 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.87155379 |
| 48 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.86039243 |
| 49 | p53 signaling pathway_Homo sapiens_hsa04115 | 0.85522391 |
| 50 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 0.82525780 |
| 51 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.82279513 |
| 52 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 0.82219661 |
| 53 | Phototransduction_Homo sapiens_hsa04744 | 0.79164173 |
| 54 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.76632672 |
| 55 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.74178295 |
| 56 | Metabolic pathways_Homo sapiens_hsa01100 | 0.70172478 |
| 57 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.68798914 |
| 58 | Carbon metabolism_Homo sapiens_hsa01200 | 0.67348012 |
| 59 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.67026926 |
| 60 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 0.64713988 |
| 61 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.62581546 |
| 62 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.62060567 |
| 63 | Peroxisome_Homo sapiens_hsa04146 | 0.61705611 |
| 64 | Sulfur relay system_Homo sapiens_hsa04122 | 0.61608048 |
| 65 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.61591160 |
| 66 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.61536455 |
| 67 | Nitrogen metabolism_Homo sapiens_hsa00910 | 0.59539240 |
| 68 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.58550457 |
| 69 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.57432389 |
| 70 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.57317027 |
| 71 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.55644598 |
| 72 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.49703494 |
| 73 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 0.49261431 |
| 74 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.47862734 |
| 75 | Galactose metabolism_Homo sapiens_hsa00052 | 0.44496013 |
| 76 | Nicotine addiction_Homo sapiens_hsa05033 | 0.41380123 |
| 77 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.41061406 |
| 78 | Legionellosis_Homo sapiens_hsa05134 | 0.39723539 |
| 79 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.39312649 |
| 80 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.37865046 |
| 81 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.37394839 |
| 82 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.36853182 |
| 83 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.36684843 |
| 84 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.36608928 |
| 85 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.36565075 |
| 86 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.36060484 |
| 87 | Pyruvate metabolism_Homo sapiens_hsa00620 | 0.35695526 |
| 88 | Other glycan degradation_Homo sapiens_hsa00511 | 0.35117031 |
| 89 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.34587243 |
| 90 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.34409452 |
| 91 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.33707412 |
| 92 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.32189623 |
| 93 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.31622404 |
| 94 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.30918099 |
| 95 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.29519522 |
| 96 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.28390665 |
| 97 | Olfactory transduction_Homo sapiens_hsa04740 | 0.26911969 |
| 98 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.26703761 |
| 99 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.26430126 |
| 100 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.26080141 |
| 101 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.24733437 |
| 102 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.24618254 |
| 103 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.24584651 |
| 104 | Measles_Homo sapiens_hsa05162 | 0.23440909 |
| 105 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.22745846 |
| 106 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.22550833 |
| 107 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.22418624 |
| 108 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.22308974 |
| 109 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.21880363 |
| 110 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.20796772 |
| 111 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.20444072 |
| 112 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.20095253 |
| 113 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.16709041 |
| 114 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.16499788 |
| 115 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.16146966 |
| 116 | Histidine metabolism_Homo sapiens_hsa00340 | 0.15821076 |
| 117 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.15179044 |
| 118 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.13517072 |
| 119 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.13098670 |
| 120 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.12493827 |
| 121 | Allograft rejection_Homo sapiens_hsa05330 | 0.12130168 |
| 122 | Retinol metabolism_Homo sapiens_hsa00830 | 0.12012316 |
| 123 | Thyroid cancer_Homo sapiens_hsa05216 | 0.11022974 |
| 124 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.10545609 |
| 125 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.09894911 |

