METTL6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)4.63221240
2behavioral response to nicotine (GO:0035095)4.34811315
3DNA strand elongation involved in DNA replication (GO:0006271)4.31282642
4telomere maintenance via semi-conservative replication (GO:0032201)4.19735596
5DNA replication initiation (GO:0006270)4.15292203
6DNA strand elongation (GO:0022616)4.10581612
7kinetochore organization (GO:0051383)4.03411874
8mitotic metaphase plate congression (GO:0007080)4.03324843
9telomere maintenance via recombination (GO:0000722)3.98069798
10platelet dense granule organization (GO:0060155)3.89628796
11DNA replication checkpoint (GO:0000076)3.84853540
12mitotic recombination (GO:0006312)3.80340097
13DNA unwinding involved in DNA replication (GO:0006268)3.77991270
14fucose catabolic process (GO:0019317)3.76338554
15L-fucose metabolic process (GO:0042354)3.76338554
16L-fucose catabolic process (GO:0042355)3.76338554
17kinetochore assembly (GO:0051382)3.66764602
18protein complex biogenesis (GO:0070271)3.64890541
19respiratory chain complex IV assembly (GO:0008535)3.64676462
20mitochondrial respiratory chain complex I assembly (GO:0032981)3.64307432
21NADH dehydrogenase complex assembly (GO:0010257)3.64307432
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.64307432
23maturation of SSU-rRNA (GO:0030490)3.63224358
24CENP-A containing nucleosome assembly (GO:0034080)3.61809459
25nucleotide-excision repair, DNA gap filling (GO:0006297)3.60407335
26protein localization to kinetochore (GO:0034501)3.53106850
27chromatin remodeling at centromere (GO:0031055)3.52996733
28mitochondrial respiratory chain complex assembly (GO:0033108)3.50128955
29response to pheromone (GO:0019236)3.50024057
30nuclear pore organization (GO:0006999)3.47404284
31metaphase plate congression (GO:0051310)3.44053892
32nuclear pore complex assembly (GO:0051292)3.39562847
33mitotic nuclear envelope disassembly (GO:0007077)3.38788601
34nucleobase biosynthetic process (GO:0046112)3.34909925
35establishment of chromosome localization (GO:0051303)3.33739521
36kynurenine metabolic process (GO:0070189)3.33525969
37protein-cofactor linkage (GO:0018065)3.32232841
38viral mRNA export from host cell nucleus (GO:0046784)3.32157942
39protein polyglutamylation (GO:0018095)3.29502130
40pseudouridine synthesis (GO:0001522)3.28507950
41telomere maintenance via telomere lengthening (GO:0010833)3.26451069
42protein localization to chromosome, centromeric region (GO:0071459)3.21049989
43DNA deamination (GO:0045006)3.20567217
44formation of translation preinitiation complex (GO:0001731)3.19504842
45attachment of spindle microtubules to kinetochore (GO:0008608)3.18769805
46IMP biosynthetic process (GO:0006188)3.18670042
47tryptophan catabolic process (GO:0006569)3.18620784
48indole-containing compound catabolic process (GO:0042436)3.18620784
49indolalkylamine catabolic process (GO:0046218)3.18620784
50purine nucleobase biosynthetic process (GO:0009113)3.18483006
51ribosomal large subunit biogenesis (GO:0042273)3.18040968
52regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.17566578
53cytochrome complex assembly (GO:0017004)3.16208110
54mannosylation (GO:0097502)3.16112771
55recombinational repair (GO:0000725)3.16039806
56proteasome assembly (GO:0043248)3.15851370
57negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.15583551
58spliceosomal snRNP assembly (GO:0000387)3.13715672
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.13398928
60detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.11992458
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.11732397
62double-strand break repair via homologous recombination (GO:0000724)3.11556264
63DNA replication-independent nucleosome assembly (GO:0006336)3.10661519
64DNA replication-independent nucleosome organization (GO:0034724)3.10661519
65peptidyl-histidine modification (GO:0018202)3.09754946
66mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.09600766
67regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.08680306
68DNA topological change (GO:0006265)3.07669961
69DNA catabolic process, exonucleolytic (GO:0000738)3.06158399
70positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.05921790
71regulation of mitotic spindle checkpoint (GO:1903504)3.05824676
72regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.05824676
73nuclear envelope disassembly (GO:0051081)3.05781974
74membrane disassembly (GO:0030397)3.05781974
75epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.05033085
76cellular ketone body metabolic process (GO:0046950)3.03921527
77nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.02696433
78ribosome biogenesis (GO:0042254)3.01090736
79water-soluble vitamin biosynthetic process (GO:0042364)3.01027601
80ribonucleoprotein complex biogenesis (GO:0022613)3.00892461
81histone exchange (GO:0043486)3.00529972
82RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00070874
83tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00070874
84indolalkylamine metabolic process (GO:0006586)2.98442373
85cell cycle G1/S phase transition (GO:0044843)2.97841342
86G1/S transition of mitotic cell cycle (GO:0000082)2.97841342
87cullin deneddylation (GO:0010388)2.96362396
88transcription-coupled nucleotide-excision repair (GO:0006283)2.95240607
89negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.92132447
90negative regulation of ligase activity (GO:0051352)2.92132447
91mitotic sister chromatid segregation (GO:0000070)2.91951488
92neural tube formation (GO:0001841)2.91898775
93rRNA processing (GO:0006364)2.91335775
94ribosomal small subunit biogenesis (GO:0042274)2.90244492
95intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.89911486
96signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.89911486
97DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.89691683
98telomere maintenance (GO:0000723)2.88472008
99protein deneddylation (GO:0000338)2.88465335
100telomere organization (GO:0032200)2.87832966
101signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.87829485
102signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.87829485
103signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.87829485
104spliceosomal complex assembly (GO:0000245)2.86961949
105translational termination (GO:0006415)2.86567823
106DNA replication-dependent nucleosome assembly (GO:0006335)2.86466132
107DNA replication-dependent nucleosome organization (GO:0034723)2.86466132
108viral transcription (GO:0019083)2.85480622
109axoneme assembly (GO:0035082)2.85173255
110epithelial cilium movement (GO:0003351)2.84609995
111chaperone-mediated protein transport (GO:0072321)2.84052138
112regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.84026298
113detection of light stimulus involved in visual perception (GO:0050908)2.82855028
114detection of light stimulus involved in sensory perception (GO:0050962)2.82855028
115negative regulation of telomere maintenance (GO:0032205)2.82703512
116histone mRNA metabolic process (GO:0008334)2.82446967
117ketone body metabolic process (GO:1902224)2.82423170
118protein neddylation (GO:0045116)2.81640990
119regulation of spindle organization (GO:0090224)2.81423954
120signal transduction involved in DNA integrity checkpoint (GO:0072401)2.81335908
121signal transduction involved in DNA damage checkpoint (GO:0072422)2.81335908
122DNA double-strand break processing (GO:0000729)2.80979780
123rRNA metabolic process (GO:0016072)2.80654215
124protein K6-linked ubiquitination (GO:0085020)2.80638792
125centriole replication (GO:0007099)2.80492531
126signal transduction involved in cell cycle checkpoint (GO:0072395)2.80251577
127ribosome assembly (GO:0042255)2.79940575
128mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.79857432
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.79436113
130regulation of cilium movement (GO:0003352)2.79059503
131preassembly of GPI anchor in ER membrane (GO:0016254)2.78275036
132tRNA processing (GO:0008033)2.77998345
133DNA strand renaturation (GO:0000733)2.77951744
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.77244016
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.76792411
136ATP synthesis coupled proton transport (GO:0015986)2.76792411
137meiotic chromosome segregation (GO:0045132)2.76683021
138nonmotile primary cilium assembly (GO:0035058)2.76407762
139establishment of integrated proviral latency (GO:0075713)2.75904601
140regulation of protein heterodimerization activity (GO:0043497)2.75315329
141IMP metabolic process (GO:0046040)2.75056243
142mitotic chromosome condensation (GO:0007076)2.74945380
143piRNA metabolic process (GO:0034587)2.74646643
144deoxyribonucleotide biosynthetic process (GO:0009263)2.74643431
145DNA ligation (GO:0006266)2.74614151
146mismatch repair (GO:0006298)2.74522945
147establishment of protein localization to mitochondrial membrane (GO:0090151)2.73785821
148cilium morphogenesis (GO:0060271)2.73637918
149pore complex assembly (GO:0046931)2.73503267
150L-methionine salvage (GO:0071267)2.72584263
151L-methionine biosynthetic process (GO:0071265)2.72584263
152amino acid salvage (GO:0043102)2.72584263
153spindle checkpoint (GO:0031577)2.72481940
1547-methylguanosine mRNA capping (GO:0006370)2.72358546
155RNA capping (GO:0036260)2.70341895
1567-methylguanosine RNA capping (GO:0009452)2.70341895
157replication fork processing (GO:0031297)2.69719074
158tryptophan metabolic process (GO:0006568)2.69596431
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.69522804
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.68751374
161reciprocal DNA recombination (GO:0035825)2.68104220
162reciprocal meiotic recombination (GO:0007131)2.68104220
163regulation of nuclear cell cycle DNA replication (GO:0033262)2.67929856
164negative regulation of DNA-dependent DNA replication (GO:2000104)2.67791560
165anterograde synaptic vesicle transport (GO:0048490)2.63844085
166G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.60960795
167rRNA modification (GO:0000154)2.60917686
168organelle disassembly (GO:1903008)2.60840448
169regulation of hexokinase activity (GO:1903299)2.56453028
170regulation of glucokinase activity (GO:0033131)2.56453028
171pyrimidine nucleobase catabolic process (GO:0006208)2.52679481
172maturation of 5.8S rRNA (GO:0000460)2.51285470
173termination of RNA polymerase III transcription (GO:0006386)2.50849306
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.50849306
175intraciliary transport (GO:0042073)2.50401273
176protein K11-linked deubiquitination (GO:0035871)2.48528152
177RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.48003793
178ubiquinone biosynthetic process (GO:0006744)2.47775059
179regulation of rhodopsin mediated signaling pathway (GO:0022400)2.46936214
180DNA demethylation (GO:0080111)2.46435888
181aldehyde catabolic process (GO:0046185)2.45423307
182photoreceptor cell maintenance (GO:0045494)2.44613177
183rhodopsin mediated signaling pathway (GO:0016056)2.44604483
184rRNA catabolic process (GO:0016075)2.44364686
185cilium organization (GO:0044782)2.43852027
186DNA methylation involved in gamete generation (GO:0043046)2.41931064
187histone H2A acetylation (GO:0043968)2.41356679
188gamma-aminobutyric acid transport (GO:0015812)2.40646872
189prenylation (GO:0097354)2.40515397
190protein prenylation (GO:0018342)2.40515397
191ubiquinone metabolic process (GO:0006743)2.39858040
192somatic diversification of immune receptors via somatic mutation (GO:0002566)2.39638748
193somatic hypermutation of immunoglobulin genes (GO:0016446)2.39638748

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.76528937
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.89404472
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.81425916
4ZNF274_21170338_ChIP-Seq_K562_Hela3.79325467
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79308836
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.71769734
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.42970361
8* GABP_17652178_ChIP-ChIP_JURKAT_Human3.37648895
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.30380151
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14404460
11VDR_22108803_ChIP-Seq_LS180_Human3.00101514
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94706648
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.85782307
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.80697608
15IGF1R_20145208_ChIP-Seq_DFB_Human2.76896569
16GBX2_23144817_ChIP-Seq_PC3_Human2.72636801
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.72340206
18* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66704288
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62886357
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61536004
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59984518
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54895581
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.53426577
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49427442
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44377570
26VDR_23849224_ChIP-Seq_CD4+_Human2.43150182
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.42066180
28FUS_26573619_Chip-Seq_HEK293_Human2.37876776
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.37199187
30* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34996307
31EWS_26573619_Chip-Seq_HEK293_Human2.34592070
32ELK1_19687146_ChIP-ChIP_HELA_Human2.34325402
33POU3F2_20337985_ChIP-ChIP_501MEL_Human2.33428601
34FOXP3_21729870_ChIP-Seq_TREG_Human2.14316129
35DCP1A_22483619_ChIP-Seq_HELA_Human2.13460801
36CTBP2_25329375_ChIP-Seq_LNCAP_Human2.13023349
37XRN2_22483619_ChIP-Seq_HELA_Human2.12090930
38SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11820352
39FLI1_27457419_Chip-Seq_LIVER_Mouse2.11427292
40HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09386015
41TAF15_26573619_Chip-Seq_HEK293_Human2.05642734
42P300_19829295_ChIP-Seq_ESCs_Human2.00512918
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98826903
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.98373522
45PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97634941
46E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97402802
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.97357659
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.95162376
49CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91116665
50MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91110478
51SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.87731312
52* GABP_19822575_ChIP-Seq_HepG2_Human1.86897751
53* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86110517
54* TTF2_22483619_ChIP-Seq_HELA_Human1.78942477
55ER_23166858_ChIP-Seq_MCF-7_Human1.78555611
56THAP11_20581084_ChIP-Seq_MESCs_Mouse1.76725538
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.76698298
58AR_21909140_ChIP-Seq_LNCAP_Human1.76188369
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.74345991
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.71098112
61* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.68427641
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.67642877
63YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67277340
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.66559068
65E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65847700
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63266957
67FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63079237
68IRF1_19129219_ChIP-ChIP_H3396_Human1.61216563
69PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60045994
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.58460448
71POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57318553
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56256336
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.51724594
74ERG_20887958_ChIP-Seq_HPC-7_Mouse1.50747552
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50642028
76TP53_22573176_ChIP-Seq_HFKS_Human1.50140850
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.49699808
78RBPJ_22232070_ChIP-Seq_NCS_Mouse1.47722318
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.47197090
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46271924
81CBP_20019798_ChIP-Seq_JUKART_Human1.45763849
82IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.45763849
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.45364060
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43839927
85EZH2_22144423_ChIP-Seq_EOC_Human1.43618570
86ZFX_18555785_ChIP-Seq_MESCs_Mouse1.41655715
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.41027844
88ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37100670
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.36872854
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35627619
91CIITA_25753668_ChIP-Seq_RAJI_Human1.34459566
92SMAD4_21799915_ChIP-Seq_A2780_Human1.34357403
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.33402129
94STAT3_23295773_ChIP-Seq_U87_Human1.32603598
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31233453
96KDM5A_27292631_Chip-Seq_BREAST_Human1.29792222
97MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29104389
98PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28732696
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.28628526
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27839977
101IRF8_21731497_ChIP-ChIP_J774_Mouse1.25909667
102KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25669776
103BCAT_22108803_ChIP-Seq_LS180_Human1.25445991
104NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24662321
105SPI1_23547873_ChIP-Seq_NB4_Human1.24403749
106TFEB_21752829_ChIP-Seq_HELA_Human1.23616311
107GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22902613
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22877817
109SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22655810
110AR_25329375_ChIP-Seq_VCAP_Human1.22442116
111* TCF4_23295773_ChIP-Seq_U87_Human1.22388357
112CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21296943
113POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20729645
114TCF4_22108803_ChIP-Seq_LS180_Human1.20232254
115SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20156729
116SOX2_19829295_ChIP-Seq_ESCs_Human1.19330740
117NANOG_19829295_ChIP-Seq_ESCs_Human1.19330740
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.19158754
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16787353
120PCGF2_27294783_Chip-Seq_NPCs_Mouse1.15613208
121NFE2_27457419_Chip-Seq_LIVER_Mouse1.14986678
122CBX2_27304074_Chip-Seq_ESCs_Mouse1.14870578
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14570805
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.14570805
125E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13752966
126FOXA1_27270436_Chip-Seq_PROSTATE_Human1.12788884
127FOXA1_25329375_ChIP-Seq_VCAP_Human1.12788884
128SMAD3_21741376_ChIP-Seq_EPCs_Human1.12447075
129GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11791731
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11622116
131NR3C1_21868756_ChIP-Seq_MCF10A_Human1.10510692
132TP63_19390658_ChIP-ChIP_HaCaT_Human1.10259842
133RNF2_27304074_Chip-Seq_NSC_Mouse1.09739772
134BMI1_23680149_ChIP-Seq_NPCS_Mouse1.07985149
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07605148
136MYC_18940864_ChIP-ChIP_HL60_Human1.06381105
137NOTCH1_21737748_ChIP-Seq_TLL_Human1.05608890
138NCOR_22424771_ChIP-Seq_293T_Human1.05499210
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05187373
140HOXB7_26014856_ChIP-Seq_BT474_Human1.03862292
141FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02952457
142RUNX2_22187159_ChIP-Seq_PCA_Human1.01952768
143FLI1_21867929_ChIP-Seq_TH2_Mouse1.01319102
144* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01063678
145CRX_20693478_ChIP-Seq_RETINA_Mouse1.00588154
146ETV2_25802403_ChIP-Seq_MESCs_Mouse0.98645661
147NANOG_18555785_Chip-Seq_ESCs_Mouse0.98402733
148GATA3_21878914_ChIP-Seq_MCF-7_Human0.98136272
149* AR_20517297_ChIP-Seq_VCAP_Human0.97989522
150ELK1_22589737_ChIP-Seq_MCF10A_Human0.97919566
151TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97558223
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96909873
153RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95548020
154* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95325449
155EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.95258294
156AUTS2_25519132_ChIP-Seq_293T-REX_Human0.94881525
157IRF8_22096565_ChIP-ChIP_GC-B_Human0.94370015
158RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94054529
159* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.93980955
160SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90794438
161CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89373432
162* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88297661
163DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.88016236
164* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86661236
165MYC_22102868_ChIP-Seq_BL_Human0.86482784
166STAT4_19710469_ChIP-ChIP_TH1__Mouse0.84380749
167SOX17_20123909_ChIP-Seq_XEN_Mouse0.82149591
168* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79564278
169CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.79152241
170VDR_21846776_ChIP-Seq_THP-1_Human0.74599880
171CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.70366816
172KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70322847
173MYB_26560356_Chip-Seq_TH2_Human0.70178084
174DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69556547
175STAT3_1855785_ChIP-Seq_MESCs_Mouse0.69305413
176NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.69070112
177PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.68867197
178HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.68500929

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.45625189
2MP0010094_abnormal_chromosome_stability4.38715487
3MP0003111_abnormal_nucleus_morphology3.72776346
4MP0004957_abnormal_blastocyst_morpholog3.59364211
5MP0003077_abnormal_cell_cycle3.57240126
6MP0008057_abnormal_DNA_replication3.47574861
7MP0008058_abnormal_DNA_repair3.38100564
8MP0008007_abnormal_cellular_replicative2.90570752
9MP0002102_abnormal_ear_morphology2.69147558
10MP0002396_abnormal_hematopoietic_system2.52733365
11MP0008932_abnormal_embryonic_tissue2.51302569
12MP0000569_abnormal_digit_pigmentation2.40056492
13MP0005551_abnormal_eye_electrophysiolog2.38800406
14MP0003880_abnormal_central_pattern2.32936081
15MP0006072_abnormal_retinal_apoptosis2.20191851
16MP0003195_calcinosis2.13935048
17MP0005645_abnormal_hypothalamus_physiol2.13628308
18MP0003123_paternal_imprinting2.07132948
19MP0008877_abnormal_DNA_methylation2.04695755
20MP0009697_abnormal_copulation2.03810641
21MP0003136_yellow_coat_color2.03201881
22MP0001529_abnormal_vocalization2.01498727
23MP0002736_abnormal_nociception_after2.00972550
24MP0001968_abnormal_touch/_nociception1.97657255
25MP0005253_abnormal_eye_physiology1.94241769
26MP0001835_abnormal_antigen_presentation1.89995987
27MP0009046_muscle_twitch1.88530112
28MP0009333_abnormal_splenocyte_physiolog1.82216499
29MP0002837_dystrophic_cardiac_calcinosis1.80580851
30MP0003786_premature_aging1.79348660
31MP0002638_abnormal_pupillary_reflex1.76834830
32MP0010352_gastrointestinal_tract_polyps1.74903013
33MP0000490_abnormal_crypts_of1.74511526
34MP0004808_abnormal_hematopoietic_stem1.73613555
35MP0000350_abnormal_cell_proliferation1.70468758
36MP0002234_abnormal_pharynx_morphology1.68537674
37MP0008872_abnormal_physiological_respon1.67312121
38MP0004142_abnormal_muscle_tone1.63838527
39MP0010307_abnormal_tumor_latency1.63679041
40MP0001730_embryonic_growth_arrest1.61463214
41MP0009745_abnormal_behavioral_response1.61106056
42MP0005646_abnormal_pituitary_gland1.55944876
43MP0000427_abnormal_hair_cycle1.55841813
44MP0006054_spinal_hemorrhage1.55358111
45MP0001485_abnormal_pinna_reflex1.55127976
46MP0003763_abnormal_thymus_physiology1.54342476
47MP0004133_heterotaxia1.50538130
48MP0005075_abnormal_melanosome_morpholog1.50014239
49MP0002272_abnormal_nervous_system1.49480291
50MP0005671_abnormal_response_to1.49226340
51MP0001986_abnormal_taste_sensitivity1.48851963
52MP0003646_muscle_fatigue1.47926714
53MP0000631_abnormal_neuroendocrine_gland1.46556404
54MP0003121_genomic_imprinting1.46419592
55MP0002398_abnormal_bone_marrow1.45175100
56MP0001984_abnormal_olfaction1.44077661
57MP0004885_abnormal_endolymph1.41590865
58MP0005174_abnormal_tail_pigmentation1.41404527
59MP0000313_abnormal_cell_death1.39416403
60MP0005084_abnormal_gallbladder_morpholo1.39355918
61MP0006276_abnormal_autonomic_nervous1.39205729
62MP0002019_abnormal_tumor_incidence1.37229555
63MP0001486_abnormal_startle_reflex1.36162887
64MP0008995_early_reproductive_senescence1.35665690
65MP0008875_abnormal_xenobiotic_pharmacok1.33922432
66MP0003436_decreased_susceptibility_to1.33823423
67MP0001697_abnormal_embryo_size1.31300525
68MP0001672_abnormal_embryogenesis/_devel1.27123791
69MP0005380_embryogenesis_phenotype1.27123791
70MP0000372_irregular_coat_pigmentation1.25983990
71MP0000689_abnormal_spleen_morphology1.25074563
72MP0002722_abnormal_immune_system1.25042262
73MP0003984_embryonic_growth_retardation1.23800308
74MP0009785_altered_susceptibility_to1.23796837
75MP0002132_abnormal_respiratory_system1.23003145
76MP0001545_abnormal_hematopoietic_system1.22428715
77MP0005397_hematopoietic_system_phenotyp1.22428715
78MP0003718_maternal_effect1.21081495
79MP0002088_abnormal_embryonic_growth/wei1.20920301
80MP0008789_abnormal_olfactory_epithelium1.20778975
81MP0000703_abnormal_thymus_morphology1.20763778
82MP0002452_abnormal_antigen_presenting1.20457202
83MP0002557_abnormal_social/conspecific_i1.18058471
84MP0002429_abnormal_blood_cell1.17412023
85MP0003941_abnormal_skin_development1.17403589
86MP0002420_abnormal_adaptive_immunity1.17288514
87MP0001853_heart_inflammation1.17210968
88MP0004742_abnormal_vestibular_system1.17123711
89MP0002080_prenatal_lethality1.17058726
90MP0002735_abnormal_chemical_nociception1.16923339
91MP0002148_abnormal_hypersensitivity_rea1.16419768
92MP0001819_abnormal_immune_cell1.16369722
93MP0000516_abnormal_urinary_system1.15669991
94MP0005367_renal/urinary_system_phenotyp1.15669991
95MP0002876_abnormal_thyroid_physiology1.15251029
96MP0001293_anophthalmia1.15184652
97MP0000858_altered_metastatic_potential1.14733749
98MP0000716_abnormal_immune_system1.12741061
99MP0004924_abnormal_behavior1.12235311
100MP0005386_behavior/neurological_phenoty1.12235311
101MP0001800_abnormal_humoral_immune1.11454207
102MP0002653_abnormal_ependyma_morphology1.10921885
103MP0005000_abnormal_immune_tolerance1.10409931
104MP0003186_abnormal_redox_activity1.10019572
105MP0005195_abnormal_posterior_eye1.09934364
106MP0002210_abnormal_sex_determination1.09781765
107MP0006035_abnormal_mitochondrial_morpho1.07423088
108MP0002067_abnormal_sensory_capabilities1.07072740
109MP0001501_abnormal_sleep_pattern1.06286346
110MP0000778_abnormal_nervous_system1.05786011
111MP0005025_abnormal_response_to1.05372037
112MP0003122_maternal_imprinting1.05330614
113MP0002419_abnormal_innate_immunity1.05214247
114MP0002572_abnormal_emotion/affect_behav1.04796352
115MP0001764_abnormal_homeostasis1.04628898
116MP0002064_seizures1.04607362
117MP0005187_abnormal_penis_morphology1.04518592
118MP0004043_abnormal_pH_regulation1.03646120
119MP0005408_hypopigmentation1.03321095
120MP0002751_abnormal_autonomic_nervous1.03316801
121MP0003011_delayed_dark_adaptation1.02330755
122MP0003937_abnormal_limbs/digits/tail_de1.02297657
123MP0002163_abnormal_gland_morphology1.01678639
124MP0002723_abnormal_immune_serum1.01282833
125MP0001905_abnormal_dopamine_level0.99993365
126MP0002085_abnormal_embryonic_tissue0.99579760
127MP0002006_tumorigenesis0.99526086
128MP0003567_abnormal_fetal_cardiomyocyte0.98437744
129MP0002752_abnormal_somatic_nervous0.98152545
130MP0003698_abnormal_male_reproductive0.97430384
131MP0004197_abnormal_fetal_growth/weight/0.95775347
132MP0002184_abnormal_innervation0.94483066
133MP0002095_abnormal_skin_pigmentation0.94423981
134MP0003635_abnormal_synaptic_transmissio0.94387009
135MP0000647_abnormal_sebaceous_gland0.92916787
136MP0003221_abnormal_cardiomyocyte_apopto0.92787190
137MP0002405_respiratory_system_inflammati0.92763773
138MP0001119_abnormal_female_reproductive0.91885103
139MP0001324_abnormal_eye_pigmentation0.91844436
140MP0005391_vision/eye_phenotype0.91240180
141MP0002086_abnormal_extraembryonic_tissu0.91073847
142MP0010386_abnormal_urinary_bladder0.90499983
143MP0005410_abnormal_fertilization0.89431886
144MP0003890_abnormal_embryonic-extraembry0.89131476
145MP0002160_abnormal_reproductive_system0.88765689
146MP0001970_abnormal_pain_threshold0.88686229
147MP0000566_synostosis0.88473481
148MP0001929_abnormal_gametogenesis0.87118379
149MP0005389_reproductive_system_phenotype0.86702897
150MP0000358_abnormal_cell_content/0.86331895
151MP0004147_increased_porphyrin_level0.86093371
152MP0002938_white_spotting0.84546068
153MP0005387_immune_system_phenotype0.83701382
154MP0001790_abnormal_immune_system0.83701382
155MP0002734_abnormal_mechanical_nocicepti0.82095740
156MP0002733_abnormal_thermal_nociception0.81993871
157MP0000383_abnormal_hair_follicle0.81292264
158MP0001145_abnormal_male_reproductive0.81068055
159MP0004215_abnormal_myocardial_fiber0.80330438
160MP0001915_intracranial_hemorrhage0.80032001
161MP0002084_abnormal_developmental_patter0.79540990
162MP0003787_abnormal_imprinting0.79355301
163MP0002063_abnormal_learning/memory/cond0.79072371
164MP0005384_cellular_phenotype0.78054296
165MP0000015_abnormal_ear_pigmentation0.77806737
166MP0002166_altered_tumor_susceptibility0.77530504
167MP0000653_abnormal_sex_gland0.76330148
168MP0005076_abnormal_cell_differentiation0.75885618
169MP0009379_abnormal_foot_pigmentation0.75177876
170MP0003950_abnormal_plasma_membrane0.74867159
171MP0006292_abnormal_olfactory_placode0.74283525
172MP0000465_gastrointestinal_hemorrhage0.73461613
173MP0005464_abnormal_platelet_physiology0.72104653
174MP0003806_abnormal_nucleotide_metabolis0.71613880
175MP0000685_abnormal_immune_system0.68821938
176MP0005621_abnormal_cell_physiology0.67564972
177MP0001186_pigmentation_phenotype0.66726944

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.72307289
2Pancreatic cysts (HP:0001737)4.44980150
3Pancreatic fibrosis (HP:0100732)3.92412436
4True hermaphroditism (HP:0010459)3.73785542
5Molar tooth sign on MRI (HP:0002419)3.68282432
6Abnormality of midbrain morphology (HP:0002418)3.68282432
7Reticulocytopenia (HP:0001896)3.67334862
8Type II lissencephaly (HP:0007260)3.40099362
9Congenital stationary night blindness (HP:0007642)3.36275701
10Abnormality of chromosome stability (HP:0003220)3.33663765
11Degeneration of anterior horn cells (HP:0002398)3.31303342
12Abnormality of the anterior horn cell (HP:0006802)3.31303342
13Breast hypoplasia (HP:0003187)3.30170379
14Chromsome breakage (HP:0040012)3.25230736
15Selective tooth agenesis (HP:0001592)3.24298197
16Aplastic anemia (HP:0001915)3.22667861
17Nephronophthisis (HP:0000090)3.21042443
18Abnormal number of erythroid precursors (HP:0012131)3.19168006
19Chromosomal breakage induced by crosslinking agents (HP:0003221)3.15488850
20Abnormality of cells of the erythroid lineage (HP:0012130)3.15436359
21Meckel diverticulum (HP:0002245)3.14672507
22Agnosia (HP:0010524)3.12029990
23Medial flaring of the eyebrow (HP:0010747)3.11845383
24Acute necrotizing encephalopathy (HP:0006965)3.02859910
25Patellar aplasia (HP:0006443)3.01795796
26Abnormality of the ileum (HP:0001549)2.95027993
27Thrombocytosis (HP:0001894)2.89954895
2811 pairs of ribs (HP:0000878)2.89763358
29Hypoplasia of the capital femoral epiphysis (HP:0003090)2.88335088
30Acute encephalopathy (HP:0006846)2.85034038
31Abnormality of the preputium (HP:0100587)2.84277496
32Mitochondrial inheritance (HP:0001427)2.81322017
33Abnormality of the renal medulla (HP:0100957)2.80486195
34Aplasia/Hypoplasia of the patella (HP:0006498)2.79008262
35Increased CSF lactate (HP:0002490)2.78690778
36Chronic hepatic failure (HP:0100626)2.75105459
37Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74971277
38Abnormality of the renal cortex (HP:0011035)2.69929934
39Progressive macrocephaly (HP:0004481)2.67822810
40Abnormal mitochondria in muscle tissue (HP:0008316)2.66362005
41Hyperventilation (HP:0002883)2.64461259
423-Methylglutaconic aciduria (HP:0003535)2.63497096
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.62255295
44Cerebellar dysplasia (HP:0007033)2.62077837
45Myelodysplasia (HP:0002863)2.61450620
46IgM deficiency (HP:0002850)2.60236569
47Hepatocellular necrosis (HP:0001404)2.58550788
48Oral leukoplakia (HP:0002745)2.56883032
49Lissencephaly (HP:0001339)2.53065540
50Attenuation of retinal blood vessels (HP:0007843)2.51930635
51Cystic liver disease (HP:0006706)2.49636840
52Gait imbalance (HP:0002141)2.49354559
53Sclerocornea (HP:0000647)2.47800454
54Bone marrow hypocellularity (HP:0005528)2.46835827
55Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.46678404
56Absent epiphyses (HP:0010577)2.46678404
57Carpal bone hypoplasia (HP:0001498)2.45348382
58Congenital primary aphakia (HP:0007707)2.43649883
59Abnormal number of incisors (HP:0011064)2.42641917
60Abnormal lung lobation (HP:0002101)2.42148232
61Nephrogenic diabetes insipidus (HP:0009806)2.42100244
62Lymphoma (HP:0002665)2.40626583
63Pendular nystagmus (HP:0012043)2.40275953
64Recurrent abscess formation (HP:0002722)2.39612151
65Hepatic necrosis (HP:0002605)2.38351111
66Aplasia/Hypoplasia of the tongue (HP:0010295)2.36640230
67Nephroblastoma (Wilms tumor) (HP:0002667)2.33989603
68Type I transferrin isoform profile (HP:0003642)2.33427194
69Irregular epiphyses (HP:0010582)2.29640566
70Mediastinal lymphadenopathy (HP:0100721)2.28568342
71Rough bone trabeculation (HP:0100670)2.28197079
72Pallor (HP:0000980)2.28129101
73Aplasia/Hypoplasia of the tibia (HP:0005772)2.25864118
74Small intestinal stenosis (HP:0012848)2.25156882
75Duodenal stenosis (HP:0100867)2.25156882
76Embryonal renal neoplasm (HP:0011794)2.24871172
77Clubbing of toes (HP:0100760)2.24310292
78Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.24248112
79Abnormality of alanine metabolism (HP:0010916)2.24248112
80Hyperalaninemia (HP:0003348)2.24248112
81Increased hepatocellular lipid droplets (HP:0006565)2.24235968
82Colon cancer (HP:0003003)2.23634045
83Supernumerary spleens (HP:0009799)2.21732849
84Intestinal atresia (HP:0011100)2.19724932
85Genital tract atresia (HP:0001827)2.17046230
86Anencephaly (HP:0002323)2.16443465
87Premature graying of hair (HP:0002216)2.14627215
88Cellular immunodeficiency (HP:0005374)2.14476404
89Granulocytopenia (HP:0001913)2.14219859
90Gaze-evoked nystagmus (HP:0000640)2.13060087
91Macrocytic anemia (HP:0001972)2.12354145
92Abnormal rod and cone electroretinograms (HP:0008323)2.11815148
93Vaginal atresia (HP:0000148)2.11100201
94Inability to walk (HP:0002540)2.10892367
95Methylmalonic acidemia (HP:0002912)2.10503186
96Sloping forehead (HP:0000340)2.10169315
97Retinal dysplasia (HP:0007973)2.09840938
98Hypoplasia of the pons (HP:0012110)2.07905728
99Abnormal spermatogenesis (HP:0008669)2.07725981
100Ectopic kidney (HP:0000086)2.07422402
101Absent radius (HP:0003974)2.07318630
102Abnormality of the pons (HP:0007361)2.07227539
103Abnormality of the labia minora (HP:0012880)2.05304924
104Abolished electroretinogram (ERG) (HP:0000550)2.04825054
105Eosinophilia (HP:0001880)2.04770183
106Progressive inability to walk (HP:0002505)2.03367548
107Renal cortical cysts (HP:0000803)2.03242608
108Absent thumb (HP:0009777)2.02054859
109Abnormality of the prostate (HP:0008775)2.01201243
110Cleft eyelid (HP:0000625)2.00626219
111Optic disc pallor (HP:0000543)1.99786838
112Polydipsia (HP:0001959)1.99710533
113Abnormal drinking behavior (HP:0030082)1.99710533
114Long clavicles (HP:0000890)1.99671110
115Triphalangeal thumb (HP:0001199)1.99411512
116Recurrent bacterial skin infections (HP:0005406)1.98877558
117Bile duct proliferation (HP:0001408)1.98314033
118Abnormal biliary tract physiology (HP:0012439)1.98314033
119Poor head control (HP:0002421)1.97840842
120Abnormality of B cell number (HP:0010975)1.96724098
121B lymphocytopenia (HP:0010976)1.96724098
122Pancytopenia (HP:0001876)1.96588883
123Optic nerve hypoplasia (HP:0000609)1.96477164
124Pulmonary fibrosis (HP:0002206)1.95859347
125Elevated erythrocyte sedimentation rate (HP:0003565)1.94967319
126IgG deficiency (HP:0004315)1.94390606
127Postaxial foot polydactyly (HP:0001830)1.93205864
128High pitched voice (HP:0001620)1.92769695
129Male pseudohermaphroditism (HP:0000037)1.92110787
130Congenital hepatic fibrosis (HP:0002612)1.92054551
131Volvulus (HP:0002580)1.90786487
132Exertional dyspnea (HP:0002875)1.89731216
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89503601
134Congenital, generalized hypertrichosis (HP:0004540)1.89380481
135Occipital encephalocele (HP:0002085)1.89171619
136Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87464836
137Pachygyria (HP:0001302)1.87208899
138Methylmalonic aciduria (HP:0012120)1.87038119
139Reduced antithrombin III activity (HP:0001976)1.86864696
140Short tibia (HP:0005736)1.86205978
141Lipid accumulation in hepatocytes (HP:0006561)1.86133050
142Increased serum lactate (HP:0002151)1.86012030
143Chorioretinal atrophy (HP:0000533)1.85475794
144Prominent nose (HP:0000448)1.85197793
145Abnormal trabecular bone morphology (HP:0100671)1.85058348
146Cerebral edema (HP:0002181)1.84553672
147Microretrognathia (HP:0000308)1.84382916
148Tubular atrophy (HP:0000092)1.84301356
149Hypothermia (HP:0002045)1.84009501
150Absent forearm bone (HP:0003953)1.83812702
151Aplasia involving forearm bones (HP:0009822)1.83812702
152Abnormality of DNA repair (HP:0003254)1.83621567
153Postaxial hand polydactyly (HP:0001162)1.83586712
154Lactic acidosis (HP:0003128)1.83562754
155Optic nerve coloboma (HP:0000588)1.83558075
156Furrowed tongue (HP:0000221)1.83296301
157Cerebral hypomyelination (HP:0006808)1.83140315
158Respiratory difficulties (HP:0002880)1.82462770
159IgA deficiency (HP:0002720)1.82225810
160Dandy-Walker malformation (HP:0001305)1.81971012
161Small hand (HP:0200055)1.81306507
162Absent speech (HP:0001344)1.81216964
163Preaxial hand polydactyly (HP:0001177)1.80044896
164Impulsivity (HP:0100710)1.79062894
165Duplicated collecting system (HP:0000081)1.78844843
166Broad-based gait (HP:0002136)1.78274238
167Eczematoid dermatitis (HP:0000976)1.77537928
168Progressive cerebellar ataxia (HP:0002073)1.76693966
169Poor coordination (HP:0002370)1.75324520
170Acute myeloid leukemia (HP:0004808)1.74986054
171Hyperglycinemia (HP:0002154)1.74689254
172Neoplasm of the pancreas (HP:0002894)1.74390920
173Astigmatism (HP:0000483)1.74082882
174Squamous cell carcinoma (HP:0002860)1.73690156
175Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73420521
176Tracheoesophageal fistula (HP:0002575)1.73079592
177Bony spicule pigmentary retinopathy (HP:0007737)1.72954808
178Abnormality of the duodenum (HP:0002246)1.72845817
179Microvesicular hepatic steatosis (HP:0001414)1.72040305
180Aseptic necrosis (HP:0010885)1.71116317
181Large for gestational age (HP:0001520)1.69395457
182Anophthalmia (HP:0000528)1.69282686
183Severe muscular hypotonia (HP:0006829)1.68312658
184Recurrent viral infections (HP:0004429)1.67958583
185Abnormality of the incisor (HP:0000676)1.67742732
186Medulloblastoma (HP:0002885)1.67686954
187Abnormal glycosylation (HP:0012345)1.67369306
188Abnormal protein N-linked glycosylation (HP:0012347)1.67369306

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.00648195
2CDC73.81823014
3EIF2AK13.61491686
4BUB13.55765056
5SRPK13.35633342
6TRIM283.10698349
7WEE12.76983463
8MAP4K22.75387701
9STK162.61155417
10ADRBK22.56755688
11EIF2AK32.55228235
12WNK32.38864194
13TTK2.34403538
14ACVR1B2.23003871
15PLK42.13359004
16CLK12.11852833
17TLK12.11574920
18VRK12.00158471
19MKNK11.96594882
20GRK11.96173617
21PINK11.84760754
22CASK1.84051979
23MAP3K41.83912973
24TSSK61.80024964
25ATR1.75201385
26MAPK131.69304506
27MKNK21.69150604
28ZAK1.65129168
29PLK11.64591480
30VRK21.64588824
31WNK41.62888910
32PIM21.62442661
33TESK21.59095063
34PLK31.58559615
35TNIK1.57651624
36NEK21.53526475
37OXSR11.53004754
38BRSK21.51119471
39NME21.49365329
40MAP2K71.46876533
41INSRR1.44538753
42NEK11.43514530
43IRAK41.43211057
44AURKB1.42007259
45STK41.39657776
46CHEK21.36397969
47PIM11.35341125
48STK391.31312454
49CDK71.30574819
50BCR1.30179713
51MARK11.30090633
52TESK11.29888120
53CCNB11.27641439
54RPS6KA41.25719101
55DYRK21.24480172
56PBK1.19687137
57TAOK31.17641277
58PASK1.16758363
59CDK81.13767717
60PAK31.13763327
61CSNK1G11.11916732
62STK31.11674738
63TEC1.10184496
64TGFBR11.09877128
65DYRK31.08791988
66CSNK1G21.07823369
67CSNK1G31.06655600
68EIF2AK21.06471764
69TXK1.05413936
70BCKDK1.04922970
71PNCK1.04075581
72RPS6KB21.02610205
73NME11.01997450
74BMPR1B1.01761804
75MST41.01600355
76TAF10.99401049
77YES10.98132267
78PIK3CA0.96768018
79MAP3K60.95468277
80MAP4K10.94481048
81PRKCG0.93636499
82CHEK10.93590725
83CAMKK20.93446385
84CSNK1A1L0.93336043
85BRSK10.91944561
86CDK40.91522780
87STK100.88821781
88AURKA0.88328356
89EPHA20.85266197
90DAPK20.84108485
91EPHA40.83213684
92ADRBK10.83076023
93NEK90.82459672
94ATM0.81046909
95MAP2K30.80447807
96MELK0.80237876
97MUSK0.78704111
98CDK190.78490720
99PRKCE0.77603374
100MAP3K140.76513169
101STK240.75732307
102BRAF0.75000871
103CSNK2A10.71794722
104KDR0.71407255
105SCYL20.69721744
106MAP3K80.68528743
107AKT30.68205679
108PAK40.68116955
109ZAP700.66733968
110PHKG20.66041766
111PHKG10.66041766
112BTK0.65978797
113STK38L0.64577438
114IKBKB0.62982471
115JAK30.62425084
116TBK10.61397997
117BRD40.61084874
118CDK20.60989587
119CSNK2A20.60675418
120KIT0.59323831
121MAP3K50.58184448
122MAPKAPK50.55194106
123FLT30.54358432
124ERBB30.53873180
125CDK10.51475948
126ABL20.51077972
127MAP3K120.50060035
128LYN0.48908108
129MINK10.47265003
130PKN10.47175497
131NUAK10.46916361
132NLK0.46874428
133RPS6KA50.45510863
134CDK120.45404243
135LIMK10.45327235
136CAMK2A0.44916473
137CHUK0.44256357
138PRKCI0.43898289
139NTRK30.42807214
140PAK10.42514506
141CSNK1A10.41973928
142IKBKE0.41756276
143SYK0.39811632
144MAP3K110.39449764
145PLK20.39287034
146TYK20.38654634
147NTRK20.36708421
148IRAK30.35579483
149LCK0.35224497
150PRKACA0.35037770
151PRKCQ0.34154846
152RPS6KB10.33834913
153FGFR20.32667297
154CSNK1D0.32588308
155TIE10.32534003
156CAMK10.31657927
157GRK50.30838083
158CSNK1E0.30633775
159MAP2K40.30147332
160MARK30.28842851
161MAP2K60.28631322

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.54052252
2Mismatch repair_Homo sapiens_hsa034303.69826955
3Proteasome_Homo sapiens_hsa030503.54514678
4Homologous recombination_Homo sapiens_hsa034403.43915146
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.20644719
6Ribosome_Homo sapiens_hsa030103.06426170
7Spliceosome_Homo sapiens_hsa030403.02492569
8RNA polymerase_Homo sapiens_hsa030203.00295731
9Base excision repair_Homo sapiens_hsa034102.78433312
10Nucleotide excision repair_Homo sapiens_hsa034202.61461590
11RNA transport_Homo sapiens_hsa030132.60922167
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.53785953
13Cell cycle_Homo sapiens_hsa041102.51726924
14Fanconi anemia pathway_Homo sapiens_hsa034602.44587478
15Phototransduction_Homo sapiens_hsa047442.41263980
16One carbon pool by folate_Homo sapiens_hsa006702.37326222
17Non-homologous end-joining_Homo sapiens_hsa034502.34926407
18Pyrimidine metabolism_Homo sapiens_hsa002402.20187158
19Basal transcription factors_Homo sapiens_hsa030222.18332378
20Butanoate metabolism_Homo sapiens_hsa006502.18031635
21Nitrogen metabolism_Homo sapiens_hsa009101.98980250
22Propanoate metabolism_Homo sapiens_hsa006401.95284912
23RNA degradation_Homo sapiens_hsa030181.90312151
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86504155
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.83965031
26Nicotine addiction_Homo sapiens_hsa050331.79354360
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.76855417
28Protein export_Homo sapiens_hsa030601.62465919
29p53 signaling pathway_Homo sapiens_hsa041151.55920073
30Linoleic acid metabolism_Homo sapiens_hsa005911.54367991
31mRNA surveillance pathway_Homo sapiens_hsa030151.49676917
32Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.47041895
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.46345316
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.46087009
35Tryptophan metabolism_Homo sapiens_hsa003801.44541731
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.43985385
37Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.42689334
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.41847187
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41070271
40Caffeine metabolism_Homo sapiens_hsa002321.33569643
41Purine metabolism_Homo sapiens_hsa002301.25150606
42Epstein-Barr virus infection_Homo sapiens_hsa051691.24274831
43Asthma_Homo sapiens_hsa053101.21620579
44Herpes simplex infection_Homo sapiens_hsa051681.20008606
45Steroid biosynthesis_Homo sapiens_hsa001001.14326764
46Peroxisome_Homo sapiens_hsa041461.14312285
47Taste transduction_Homo sapiens_hsa047421.12969305
48Legionellosis_Homo sapiens_hsa051341.12562463
49Olfactory transduction_Homo sapiens_hsa047401.06873194
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.04238117
51Ether lipid metabolism_Homo sapiens_hsa005651.02568498
52Systemic lupus erythematosus_Homo sapiens_hsa053221.01978072
53Antigen processing and presentation_Homo sapiens_hsa046121.01029122
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.97274060
55Cardiac muscle contraction_Homo sapiens_hsa042600.96635670
56Regulation of autophagy_Homo sapiens_hsa041400.92064862
57Huntingtons disease_Homo sapiens_hsa050160.90141369
58Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89753697
59Morphine addiction_Homo sapiens_hsa050320.89436691
60Primary bile acid biosynthesis_Homo sapiens_hsa001200.89056656
61Measles_Homo sapiens_hsa051620.86895677
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.86717808
63Pentose phosphate pathway_Homo sapiens_hsa000300.86621505
64Allograft rejection_Homo sapiens_hsa053300.86040517
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.85848083
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84995096
67Primary immunodeficiency_Homo sapiens_hsa053400.83715703
68Viral carcinogenesis_Homo sapiens_hsa052030.83330273
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82394731
70Fatty acid elongation_Homo sapiens_hsa000620.81975642
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79621675
72Parkinsons disease_Homo sapiens_hsa050120.79405762
73Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79145280
74beta-Alanine metabolism_Homo sapiens_hsa004100.77571247
75Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77181965
76Chemical carcinogenesis_Homo sapiens_hsa052040.76715101
77Leishmaniasis_Homo sapiens_hsa051400.75877148
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.74724162
79Oxidative phosphorylation_Homo sapiens_hsa001900.74460661
80GABAergic synapse_Homo sapiens_hsa047270.72932074
81Intestinal immune network for IgA production_Homo sapiens_hsa046720.72230966
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70981520
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70763429
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70326263
85Shigellosis_Homo sapiens_hsa051310.69469759
86Hematopoietic cell lineage_Homo sapiens_hsa046400.68898986
87Oocyte meiosis_Homo sapiens_hsa041140.65555885
88Retinol metabolism_Homo sapiens_hsa008300.64957719
89Collecting duct acid secretion_Homo sapiens_hsa049660.64817002
90Sulfur metabolism_Homo sapiens_hsa009200.63642739
91HTLV-I infection_Homo sapiens_hsa051660.62897146
92N-Glycan biosynthesis_Homo sapiens_hsa005100.62879393
93Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62220107
94Hepatitis B_Homo sapiens_hsa051610.60758518
95ABC transporters_Homo sapiens_hsa020100.60689989
96Influenza A_Homo sapiens_hsa051640.58385925
97Apoptosis_Homo sapiens_hsa042100.56888528
98Sulfur relay system_Homo sapiens_hsa041220.56849226
99Serotonergic synapse_Homo sapiens_hsa047260.56675818
100Glutamatergic synapse_Homo sapiens_hsa047240.56450736
101Vitamin B6 metabolism_Homo sapiens_hsa007500.56408964
102Graft-versus-host disease_Homo sapiens_hsa053320.56295609
103Circadian entrainment_Homo sapiens_hsa047130.55917823
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55562148
105Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54084380
106Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.52971216
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52627874
108MicroRNAs in cancer_Homo sapiens_hsa052060.52258850
109Insulin secretion_Homo sapiens_hsa049110.49848471
110Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.49336284
111Small cell lung cancer_Homo sapiens_hsa052220.48219615
112Phagosome_Homo sapiens_hsa041450.46767946
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46729670
114Fatty acid metabolism_Homo sapiens_hsa012120.46673083
115Folate biosynthesis_Homo sapiens_hsa007900.46201487
116Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.45593250
117Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45281131
118Glycerolipid metabolism_Homo sapiens_hsa005610.45201383
119Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.44946721
120Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44866202
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.44130442
122Glutathione metabolism_Homo sapiens_hsa004800.40318704
123Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.40197714
124Autoimmune thyroid disease_Homo sapiens_hsa053200.40189648
125Circadian rhythm_Homo sapiens_hsa047100.39832473
126Fatty acid degradation_Homo sapiens_hsa000710.39028491
127Toll-like receptor signaling pathway_Homo sapiens_hsa046200.38098171
128Pertussis_Homo sapiens_hsa051330.38011710
129Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36911180
130Fat digestion and absorption_Homo sapiens_hsa049750.35234496
131Dopaminergic synapse_Homo sapiens_hsa047280.34859081
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.33800695
133HIF-1 signaling pathway_Homo sapiens_hsa040660.32876058
134Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31967004
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31858491
136TGF-beta signaling pathway_Homo sapiens_hsa043500.31606815
137Tuberculosis_Homo sapiens_hsa051520.31029071
138Viral myocarditis_Homo sapiens_hsa054160.31014183
139Ovarian steroidogenesis_Homo sapiens_hsa049130.30911454
140Alzheimers disease_Homo sapiens_hsa050100.30740043
141Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30537861
142Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30097337
143Thyroid cancer_Homo sapiens_hsa052160.30009890
144Type I diabetes mellitus_Homo sapiens_hsa049400.29414517
145Malaria_Homo sapiens_hsa051440.29129482
146Jak-STAT signaling pathway_Homo sapiens_hsa046300.27007590
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.26270201
148Selenocompound metabolism_Homo sapiens_hsa004500.26196501
149Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.25356419
150Biosynthesis of amino acids_Homo sapiens_hsa012300.25296167
151Sphingolipid metabolism_Homo sapiens_hsa006000.24508742
152Salmonella infection_Homo sapiens_hsa051320.24082776
153Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22542148
154Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.21940746
155Galactose metabolism_Homo sapiens_hsa000520.21209027
156Arachidonic acid metabolism_Homo sapiens_hsa005900.20666645
157Other glycan degradation_Homo sapiens_hsa005110.20238353
158Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.19573691
159Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.18934370
160Metabolic pathways_Homo sapiens_hsa011000.18644825

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