ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	exogenous drug catabolic process (GO:0042738)	6.43539533
2	ethanol oxidation (GO:0006069)	6.22088764
3	drug catabolic process (GO:0042737)	5.81910860
4	ethanol metabolic process (GO:0006067)	5.55591616
5	regulation of protein activation cascade (GO:2000257)	5.41635341
6	epoxygenase P450 pathway (GO:0019373)	5.30347326
7	regulation of complement activation (GO:0030449)	5.26773843
8	complement activation, alternative pathway (GO:0006957)	5.23760435
9	negative regulation of fibrinolysis (GO:0051918)	5.06016058
10	regulation of fibrinolysis (GO:0051917)	4.84860744
11	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	4.62848681
12	L-phenylalanine catabolic process (GO:0006559)	4.62848681
13	omega-hydroxylase P450 pathway (GO:0097267)	4.56672245
14	primary alcohol catabolic process (GO:0034310)	4.31475189
15	glyoxylate metabolic process (GO:0046487)	4.26279412
16	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.21592711
17	L-phenylalanine metabolic process (GO:0006558)	4.21592711
18	protein carboxylation (GO:0018214)	4.12372538
19	peptidyl-glutamic acid carboxylation (GO:0017187)	4.12372538
20	negative regulation of cholesterol transport (GO:0032375)	4.06306982
21	negative regulation of sterol transport (GO:0032372)	4.06306982
22	drug metabolic process (GO:0017144)	4.06154580
23	amino-acid betaine metabolic process (GO:0006577)	4.05577760
24	cellular glucuronidation (GO:0052695)	4.05552961
25	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	4.01539646
26	urea metabolic process (GO:0019627)	3.97117894
27	regulation of triglyceride catabolic process (GO:0010896)	3.86771428
28	glucuronate metabolic process (GO:0019585)	3.81639153
29	uronic acid metabolic process (GO:0006063)	3.81639153
30	blood coagulation, intrinsic pathway (GO:0007597)	3.77937132
31	fibrinolysis (GO:0042730)	3.75640385
32	negative regulation of protein activation cascade (GO:2000258)	3.75231536
33	protein activation cascade (GO:0072376)	3.73932886
34	complement activation, classical pathway (GO:0006958)	3.73473846
35	phospholipid efflux (GO:0033700)	3.72627557
36	bile acid biosynthetic process (GO:0006699)	3.71443127
37	nitrogen cycle metabolic process (GO:0071941)	3.71290839
38	bile acid metabolic process (GO:0008206)	3.70293806
39	complement activation (GO:0006956)	3.69220808
40	regulation of cholesterol esterification (GO:0010872)	3.57371630
41	protein-lipid complex remodeling (GO:0034368)	3.56453068
42	macromolecular complex remodeling (GO:0034367)	3.56453068
43	plasma lipoprotein particle remodeling (GO:0034369)	3.56453068
44	negative regulation of humoral immune response (GO:0002921)	3.53742349
45	regulation of humoral immune response (GO:0002920)	3.49063976
46	alpha-linolenic acid metabolic process (GO:0036109)	3.47893842
47	axonemal dynein complex assembly (GO:0070286)	3.47096935
48	regulation of apoptotic cell clearance (GO:2000425)	3.44589370
49	response to mercury ion (GO:0046689)	3.44253947
50	high-density lipoprotein particle remodeling (GO:0034375)	3.41852637
51	negative regulation of complement activation (GO:0045916)	3.40156549
52	very-low-density lipoprotein particle assembly (GO:0034379)	3.39643070
53	acylglycerol homeostasis (GO:0055090)	3.39247236
54	triglyceride homeostasis (GO:0070328)	3.39247236
55	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	3.38454345
56	urea cycle (GO:0000050)	3.37658349
57	plasma lipoprotein particle clearance (GO:0034381)	3.37655251
58	cilium or flagellum-dependent cell motility (GO:0001539)	3.37203194
59	aromatic amino acid family catabolic process (GO:0009074)	3.37007472
60	reverse cholesterol transport (GO:0043691)	3.33818539
61	bile acid and bile salt transport (GO:0015721)	3.32654225
62	carnitine metabolic process (GO:0009437)	3.30699198
63	primary alcohol metabolic process (GO:0034308)	3.30661867
64	cholesterol efflux (GO:0033344)	3.28591231
65	positive regulation of lipoprotein lipase activity (GO:0051006)	3.26319602
66	positive regulation of triglyceride lipase activity (GO:0061365)	3.26319602
67	negative regulation of blood coagulation (GO:0030195)	3.26152382
68	negative regulation of hemostasis (GO:1900047)	3.26152382
69	flavonoid metabolic process (GO:0009812)	3.14617324
70	fat-soluble vitamin biosynthetic process (GO:0042362)	3.13105211
71	acute-phase response (GO:0006953)	3.08364929
72	positive regulation of hemostasis (GO:1900048)	3.07282494
73	positive regulation of blood coagulation (GO:0030194)	3.07282494
74	negative regulation of lipase activity (GO:0060192)	3.06428571
75	low-density lipoprotein particle remodeling (GO:0034374)	3.04363090
76	phospholipid homeostasis (GO:0055091)	3.00839536
77	oxidative demethylation (GO:0070989)	2.98209592
78	phenylpropanoid metabolic process (GO:0009698)	2.94982196
79	positive regulation of lipid catabolic process (GO:0050996)	2.91672264
80	negative regulation of coagulation (GO:0050819)	2.91666697
81	plasma lipoprotein particle organization (GO:0071827)	2.91444145
82	positive regulation of coagulation (GO:0050820)	2.91433980
83	plasma lipoprotein particle assembly (GO:0034377)	2.84249792
84	regulation of plasminogen activation (GO:0010755)	2.83781786
85	xenobiotic metabolic process (GO:0006805)	2.83382380
86	glutamate metabolic process (GO:0006536)	2.81474561
87	protein-lipid complex subunit organization (GO:0071825)	2.79420836
88	intestinal cholesterol absorption (GO:0030299)	2.77258086
89	regulation of cholesterol metabolic process (GO:0090181)	2.76828579
90	sodium ion homeostasis (GO:0055078)	2.76133068
91	triglyceride catabolic process (GO:0019433)	2.74877990
92	serine family amino acid catabolic process (GO:0009071)	2.73634348
93	negative regulation of wound healing (GO:0061045)	2.73482721
94	hormone catabolic process (GO:0042447)	2.73205713
95	alkaloid metabolic process (GO:0009820)	2.72736408
96	neutral lipid catabolic process (GO:0046461)	2.70412391
97	acylglycerol catabolic process (GO:0046464)	2.70412391
98	negative regulation of immunoglobulin mediated immune response (GO:0002890)	2.69353548
99	negative regulation of B cell mediated immunity (GO:0002713)	2.69353548
100	low-density lipoprotein particle clearance (GO:0034383)	2.65247087

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	5.32379017
2	RXR_22158963_ChIP-Seq_LIVER_Mouse	3.77584186
3	LXR_22158963_ChIP-Seq_LIVER_Mouse	3.47770422
4	PPARA_22158963_ChIP-Seq_LIVER_Mouse	3.29687673
5	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	3.18043178
6	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	3.06444752
7	EGR1_23403033_ChIP-Seq_LIVER_Mouse	3.01557458
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	2.41785686
9	IRF8_22096565_ChIP-ChIP_GC-B_Human	2.23453694
10	DROSHA_22980978_ChIP-Seq_HELA_Human	1.97132506
11	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.94949028
12	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.83569102
13	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.75826097
14	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.73021528
15	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.71914529
16	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.65619128
17	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.63036477
18	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.57927416
19	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.51311600
20	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.46480835
21	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.43522844
22	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.39292880
23	GATA1_19941826_ChIP-Seq_K562_Human	1.37717106
24	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.36847558
25	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.32789909
26	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.32002499
27	* AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.31410332
28	GATA1_22025678_ChIP-Seq_K562_Human	1.26841730
29	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.25686728
30	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.25233282
31	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	1.24720130
32	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.23990083
33	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.23544507
34	GATA1_19941827_ChIP-Seq_MEL_Mouse	1.19854068
35	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.17996958
36	CLOCK_20551151_ChIP-Seq_293T_Human	1.17615103
37	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.14604424
38	CDX2_20551321_ChIP-Seq_CACO-2_Human	1.11772374
39	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.11099874
40	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.08820523
41	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.07086620
42	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.06694592
43	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.03631246
44	* ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.02979924
45	GATA2_19941826_ChIP-Seq_K562_Human	1.02606828
46	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	1.02494671
47	LXR_22292898_ChIP-Seq_THP-1_Human	1.01969514
48	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.00258622
49	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.98348930
50	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.94138748
51	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.93930152
52	TBX20_22328084_ChIP-Seq_HEART_Mouse	0.93147145
53	TBX20_22080862_ChIP-Seq_HEART_Mouse	0.93147145
54	BP1_19119308_ChIP-ChIP_Hs578T_Human	0.93011908
55	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.92910555
56	SMC4_20622854_ChIP-Seq_HELA_Human	0.91231343
57	* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.89399037
58	GATA4_25053715_ChIP-Seq_YYC3_Human	0.89365595
59	RUNX_20019798_ChIP-Seq_JUKART_Human	0.88173505
60	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.87650509
61	* SOX2_20726797_ChIP-Seq_SW620_Human	0.86919397
62	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	0.83989623
63	AHR_22903824_ChIP-Seq_MCF-7_Human	0.83364402
64	VDR_24787735_ChIP-Seq_THP-1_Human	0.83228220
65	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.82412458
66	SOX9_24532713_ChIP-Seq_HFSC_Mouse	0.82310479
67	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.81984177
68	SPI1_23127762_ChIP-Seq_K562_Human	0.81859940
69	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.81770282
70	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.81336073
71	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.80984103
72	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.80895159
73	* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.80419003
74	AR_21572438_ChIP-Seq_LNCaP_Human	0.79450443
75	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	0.77838363
76	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.77545311
77	CEBPB_22108803_ChIP-Seq_LS180_Human	0.76898879
78	SCL_19346495_ChIP-Seq_HPC-7_Human	0.76886929
79	GATA2_20887958_ChIP-Seq_HPC-7_Mouse	0.76310283
80	MTF2_20144788_ChIP-Seq_MESCs_Mouse	0.76248520
81	BCAT_22108803_ChIP-Seq_LS180_Human	0.75651123
82	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	0.74529350
83	* P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.73195529
84	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.72190958
85	CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.72068793
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.70186917
87	TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.70012508
88	WT1_25993318_ChIP-Seq_PODOCYTE_Human	0.69418666
89	NFIB_24661679_ChIP-Seq_LUNG_Mouse	0.68348202
90	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.67793128
91	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.67453872
92	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.67453872
93	KDM2B_26808549_Chip-Seq_SUP-B15_Human	0.67243565
94	ARNT_22903824_ChIP-Seq_MCF-7_Human	0.67198785
95	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.66638516
96	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.66079043
97	TP63_23658742_ChIP-Seq_EP156T_Human	0.65748660
98	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	0.64500686
99	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.64292645
100	TP63_22573176_ChIP-Seq_HFKS_Human	0.63843562

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	7.04885399
2	MP0005365_abnormal_bile_salt	4.69749844
3	MP0008875_abnormal_xenobiotic_pharmacok	4.48772901
4	MP0005085_abnormal_gallbladder_physiolo	4.18938370
5	MP0005360_urolithiasis	3.87989343
6	MP0003195_calcinosis	3.36344697
7	MP0010329_abnormal_lipoprotein_level	3.00981588
8	MP0003252_abnormal_bile_duct	2.69078766
9	MP0003868_abnormal_feces_composition	2.48556885
10	MP0001666_abnormal_nutrient_absorption	2.47244086
11	MP0003191_abnormal_cellular_cholesterol	2.44182130
12	MP0002876_abnormal_thyroid_physiology	2.42961447
13	MP0002138_abnormal_hepatobiliary_system	2.38204182
14	MP0003690_abnormal_glial_cell	2.27263425
15	MP0005670_abnormal_white_adipose	2.24676256
16	MP0009840_abnormal_foam_cell	2.06781479
17	MP0004043_abnormal_pH_regulation	2.04855815
18	MP0004130_abnormal_muscle_cell	2.04278976
19	MP0002118_abnormal_lipid_homeostasis	1.94734418
20	MP0005332_abnormal_amino_acid	1.93839622
21	MP0002971_abnormal_brown_adipose	1.73773134
22	MP0003656_abnormal_erythrocyte_physiolo	1.69304564
23	MP0002132_abnormal_respiratory_system	1.66181157
24	MP0009780_abnormal_chondrocyte_physiolo	1.62120378
25	MP0000609_abnormal_liver_physiology	1.60318486
26	MP0003879_abnormal_hair_cell	1.52616366
27	MP0004019_abnormal_vitamin_homeostasis	1.48534965
28	MP0000604_amyloidosis	1.46529059
29	MP0009643_abnormal_urine_homeostasis	1.45876314
30	MP0003724_increased_susceptibility_to	1.41364076
31	MP0005058_abnormal_lysosome_morphology	1.37642728
32	MP0003329_amyloid_beta_deposits	1.35136697
33	MP0003303_peritoneal_inflammation	1.33875504
34	MP0003075_altered_response_to	1.29118703
35	MP0003183_abnormal_peptide_metabolism	1.28436430
36	MP0005666_abnormal_adipose_tissue	1.26335941
37	MP0005584_abnormal_enzyme/coenzyme_acti	1.24601636
38	MP0005167_abnormal_blood-brain_barrier	1.19543786
39	MP0005636_abnormal_mineral_homeostasis	1.19045506
40	MP0005535_abnormal_body_temperature	1.16726480
41	MP0001661_extended_life_span	1.11712775
42	MP0001764_abnormal_homeostasis	1.09535104
43	MP0005319_abnormal_enzyme/_coenzyme	1.01773391
44	MP0004883_abnormal_blood_vessel	1.01735052
45	MP0009115_abnormal_fat_cell	0.99520638
46	MP0002909_abnormal_adrenal_gland	0.98826128
47	MP0003011_delayed_dark_adaptation	0.98334159
48	MP0000920_abnormal_myelination	0.97183138
49	MP0001756_abnormal_urination	0.94951960
50	MP0005464_abnormal_platelet_physiology	0.94323605
51	MP0002638_abnormal_pupillary_reflex	0.93616840
52	MP0005451_abnormal_body_composition	0.93418861
53	MP0003172_abnormal_lysosome_physiology	0.92908462
54	MP0005334_abnormal_fat_pad	0.92024799
55	MP0002078_abnormal_glucose_homeostasis	0.91797619
56	MP0005166_decreased_susceptibility_to	0.91410127
57	MP0005083_abnormal_biliary_tract	0.89790557
58	MP0005164_abnormal_response_to	0.88880038
59	MP0009642_abnormal_blood_homeostasis	0.87383729
60	MP0000681_abnormal_thyroid_gland	0.87163752
61	MP0001765_abnormal_ion_homeostasis	0.86312990
62	MP0000249_abnormal_blood_vessel	0.86128637
63	MP0008469_abnormal_protein_level	0.85796954
64	MP0002168_other_aberrant_phenotype	0.83982665
65	MP0003633_abnormal_nervous_system	0.83807643
66	MP0003638_abnormal_response/metabolism_	0.83013974
67	MP0003806_abnormal_nucleotide_metabolis	0.81112467
68	MP0003300_gastrointestinal_ulcer	0.80832578
69	MP0001984_abnormal_olfaction	0.80503880
70	MP0009763_increased_sensitivity_to	0.80231699
71	MP0001501_abnormal_sleep_pattern	0.79821531
72	MP0005448_abnormal_energy_balance	0.78146724
73	MP0002136_abnormal_kidney_physiology	0.77764803
74	MP0005387_immune_system_phenotype	0.77391576
75	MP0001790_abnormal_immune_system	0.77391576
76	MP0005025_abnormal_response_to	0.74653779
77	MP0002419_abnormal_innate_immunity	0.74439193
78	MP0010155_abnormal_intestine_physiology	0.73981632
79	MP0009764_decreased_sensitivity_to	0.73369483
80	MP0000685_abnormal_immune_system	0.73274374
81	MP0003632_abnormal_nervous_system	0.73157700
82	MP0005375_adipose_tissue_phenotype	0.71715745
83	MP0004147_increased_porphyrin_level	0.71446202
84	MP0003436_decreased_susceptibility_to	0.70307215
85	MP0010368_abnormal_lymphatic_system	0.69306864
86	MP0005376_homeostasis/metabolism_phenot	0.68779821
87	MP0006082_CNS_inflammation	0.67721641
88	MP0003631_nervous_system_phenotype	0.67225336
89	MP0001986_abnormal_taste_sensitivity	0.66985331
90	MP0004782_abnormal_surfactant_physiolog	0.66809352
91	MP0000598_abnormal_liver_morphology	0.66497326
92	MP0004885_abnormal_endolymph	0.65963102
93	MP0008874_decreased_physiological_sensi	0.64510177
94	MP0001533_abnormal_skeleton_physiology	0.64431729
95	MP0001851_eye_inflammation	0.63276990
96	MP0005647_abnormal_sex_gland	0.62652858
97	MP0003953_abnormal_hormone_level	0.61730765
98	MP0009785_altered_susceptibility_to	0.59938072
99	MP0001845_abnormal_inflammatory_respons	0.57626229
100	MP0002970_abnormal_white_adipose	0.56189338

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Complement deficiency (HP:0004431)	7.12899886
2	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.54438830
3	Deep venous thrombosis (HP:0002625)	5.97708956
4	Abnormality of complement system (HP:0005339)	5.68214057
5	Systemic lupus erythematosus (HP:0002725)	5.67168765
6	Glomerulonephritis (HP:0000099)	4.79870261
7	Prolonged partial thromboplastin time (HP:0003645)	4.68634602
8	Hypobetalipoproteinemia (HP:0003563)	4.52402384
9	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	4.35806987
10	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.35777420
11	Xanthomatosis (HP:0000991)	3.98711573
12	Absent/shortened dynein arms (HP:0200106)	3.98202030
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.98202030
14	Joint hemorrhage (HP:0005261)	3.97221196
15	Abnormal respiratory epithelium morphology (HP:0012253)	3.95924789
16	Abnormal respiratory motile cilium morphology (HP:0005938)	3.95924789
17	Hyperlipoproteinemia (HP:0010980)	3.94215430
18	Recurrent gram-negative bacterial infections (HP:0005420)	3.88584176
19	Abnormal ciliary motility (HP:0012262)	3.80524837
20	Abnormal respiratory motile cilium physiology (HP:0012261)	3.77157763
21	Rhinitis (HP:0012384)	3.57196075
22	Conjugated hyperbilirubinemia (HP:0002908)	3.48106507
23	Nephritis (HP:0000123)	3.38580838
24	Abnormality of the common coagulation pathway (HP:0010990)	2.98588329
25	Abnormality of glutamine family amino acid metabolism (HP:0010902)	2.98173358
26	Hyperactive renin-angiotensin system (HP:0000841)	2.97798278
27	Hemorrhage of the eye (HP:0011885)	2.93564032
28	Fat malabsorption (HP:0002630)	2.92169428
29	Chronic bronchitis (HP:0004469)	2.91829957
30	Intrahepatic cholestasis (HP:0001406)	2.85171333
31	Nasal polyposis (HP:0100582)	2.76199739
32	Bronchiectasis (HP:0002110)	2.75551578
33	Spontaneous abortion (HP:0005268)	2.73963889
34	Purpura (HP:0000979)	2.71009333
35	Hypolipoproteinemia (HP:0010981)	2.68778764
36	Decreased circulating renin level (HP:0003351)	2.63650316
37	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	2.63166183
38	Abnormality of the nasal mucosa (HP:0000433)	2.57320584
39	Steatorrhea (HP:0002570)	2.47032153
40	Gingival bleeding (HP:0000225)	2.43625863
41	Rickets (HP:0002748)	2.43412716
42	Mitral stenosis (HP:0001718)	2.40351306
43	Hypercholesterolemia (HP:0003124)	2.37566063
44	Recurrent sinusitis (HP:0011108)	2.34539201
45	Vascular calcification (HP:0004934)	2.33122855
46	Epidermoid cyst (HP:0200040)	2.32117787
47	Amyloidosis (HP:0011034)	2.32025830
48	Hyperammonemia (HP:0001987)	2.31541400
49	Pulmonary embolism (HP:0002204)	2.28791372
50	Alkalosis (HP:0001948)	2.26054851
51	Abnormality of renin-angiotensin system (HP:0000847)	2.24033741
52	Hyperaldosteronism (HP:0000859)	2.20569100
53	Bronchitis (HP:0012387)	2.14816157
54	Hypokalemic alkalosis (HP:0001949)	2.13294686
55	Poikilocytosis (HP:0004447)	2.06662065
56	Hyperglycinuria (HP:0003108)	2.05196202
57	Thrombophlebitis (HP:0004418)	2.03852471
58	Hydroxyprolinuria (HP:0003080)	2.01302270
59	Abnormality of proline metabolism (HP:0010907)	2.01302270
60	Cardiovascular calcification (HP:0011915)	2.00267601
61	Urinary glycosaminoglycan excretion (HP:0003541)	1.96546246
62	Mucopolysacchariduria (HP:0008155)	1.96546246
63	Facial shape deformation (HP:0011334)	1.95207038
64	Potter facies (HP:0002009)	1.95207038
65	Recurrent otitis media (HP:0000403)	1.94869487
66	Polycythemia (HP:0001901)	1.93676170
67	Skin nodule (HP:0200036)	1.88546022
68	Abnormality of glycine metabolism (HP:0010895)	1.86413152
69	Abnormality of serine family amino acid metabolism (HP:0010894)	1.86413152
70	Renal salt wasting (HP:0000127)	1.86088936
71	Abnormality of polysaccharide metabolism (HP:0011012)	1.85009778
72	Abnormality of glycosaminoglycan metabolism (HP:0004371)	1.85009778
73	Abnormality of mucopolysaccharide metabolism (HP:0011020)	1.85009778
74	Abnormality of pyrimidine metabolism (HP:0004353)	1.84290870
75	Myocardial infarction (HP:0001658)	1.83123101
76	Hyperkalemia (HP:0002153)	1.82900859
77	Abnormality of the intrinsic pathway (HP:0010989)	1.82431386
78	Acanthocytosis (HP:0001927)	1.78248031
79	Abnormality of vitamin metabolism (HP:0100508)	1.76598278
80	Abnormality of the periventricular white matter (HP:0002518)	1.76124569
81	Goiter (HP:0000853)	1.71361360
82	Osteomalacia (HP:0002749)	1.70110055
83	Eczematoid dermatitis (HP:0000976)	1.69803479
84	Neurofibrillary tangles (HP:0002185)	1.67650510
85	Hypoalphalipoproteinemia (HP:0003233)	1.66501307
86	Dysostosis multiplex (HP:0000943)	1.65550141
87	Orchitis (HP:0100796)	1.64188209
88	Infertility (HP:0000789)	1.64159096
89	Myositis (HP:0100614)	1.63338929
90	Hypertriglyceridemia (HP:0002155)	1.63334315
91	Polygenic inheritance (HP:0010982)	1.62882865
92	Hypokalemia (HP:0002900)	1.62774884
93	Recurrent bronchitis (HP:0002837)	1.61869170
94	Abnormality of fatty-acid metabolism (HP:0004359)	1.61264609
95	Abnormality of iron homeostasis (HP:0011031)	1.61011769
96	Abnormality of chloride homeostasis (HP:0011422)	1.60229734
97	Ventricular fibrillation (HP:0001663)	1.59932074
98	Metabolic alkalosis (HP:0200114)	1.59220711
99	Increased circulating renin level (HP:0000848)	1.59213027
100	Epistaxis (HP:0000421)	1.58867957

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ERN1	3.61278980
2	MAPK15	2.96803881
3	RIPK1	2.69878627
4	RIPK4	2.38980619
5	TRIB3	2.32359638
6	BLK	2.14497232
7	TYK2	2.03098113
8	PRPF4B	2.02796734
9	NTRK3	1.96203567
10	FGFR4	1.85897586
11	MAPKAPK3	1.77870632
12	FGFR3	1.74898858
13	TNK2	1.63712449
14	PRKAA2	1.61265931
15	MAP3K2	1.54443704
16	SGK2	1.52465763
17	PDPK1	1.51637863
18	EPHA3	1.47747363
19	EEF2K	1.42188936
20	MAPK12	1.39124612
21	JAK1	1.33346222
22	MAP3K13	1.29946622
23	PDK1	1.28223010
24	SGK3	1.27666880
25	SGK494	1.25502793
26	SGK223	1.25502793
27	JAK2	1.23599721
28	FRK	1.22546807
29	MAP3K3	1.21414617
30	PIK3CG	1.20919905
31	MARK2	1.18131645
32	CSK	1.16082718
33	FES	1.14999523
34	RET	1.12376734
35	MAP3K7	1.06546128
36	PIK3CA	1.06023864
37	KSR2	1.05410519
38	MAP3K1	1.04146410
39	CAMKK1	1.03583563
40	DAPK2	1.03055833
41	CAMKK2	1.01837140
42	TBK1	0.99648913
43	EPHB1	0.97974648
44	TGFBR2	0.97679322
45	TAOK3	0.94352229
46	ZAP70	0.92715754
47	NEK9	0.91382633
48	MAP2K3	0.90091002
49	SGK1	0.89745279
50	MAPK7	0.88829516
51	NEK6	0.88192721
52	PINK1	0.87985340
53	MAPK11	0.85906531
54	MAP4K1	0.85439434
55	FER	0.83654519
56	ACVR1B	0.83455324
57	NLK	0.81692924
58	ICK	0.81255795
59	ERBB2	0.81167725
60	TRPM7	0.80794958
61	CDC42BPA	0.78523833
62	PRKACG	0.78402891
63	CAMK1D	0.75353929
64	JAK3	0.73653158
65	IRAK1	0.73552091
66	MAP2K1	0.69769709
67	SYK	0.68928499
68	CSF1R	0.68853784
69	SIK1	0.67620754
70	GRK6	0.66130477
71	MAPK4	0.63999768
72	MAP2K4	0.61884872
73	PRKCZ	0.59063061
74	PRKAA1	0.58033944
75	AKT3	0.57867197
76	PRKD1	0.56623475
77	ITK	0.56579141
78	CDK6	0.55310919
79	MAP2K2	0.54395744
80	PHKG2	0.53739998
81	PHKG1	0.53739998
82	IGF1R	0.53480923
83	HIPK2	0.52249605
84	PDK2	0.52075610
85	LYN	0.51462307
86	BTK	0.50689672
87	YES1	0.49808855
88	DYRK1B	0.49783297
89	HCK	0.49195240
90	KIT	0.48878776
91	CAMK1	0.48844565
92	PRKG1	0.48225236
93	OBSCN	0.47945307
94	FYN	0.47392536
95	GRK5	0.44866447
96	IKBKE	0.44759166
97	OXSR1	0.43926169
98	PRKCQ	0.43583299
99	PKN1	0.43496871
100	BMPR2	0.43267098

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Caffeine metabolism_Homo sapiens_hsa00232	3.31755631
2	Complement and coagulation cascades_Homo sapiens_hsa04610	3.17495949
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.09990956
4	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.92182809
5	Histidine metabolism_Homo sapiens_hsa00340	2.89795791
6	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.84941402
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.73389489
8	Retinol metabolism_Homo sapiens_hsa00830	2.71108831
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.68015371
10	Fatty acid degradation_Homo sapiens_hsa00071	2.63291827
11	Phenylalanine metabolism_Homo sapiens_hsa00360	2.62069605
12	Tyrosine metabolism_Homo sapiens_hsa00350	2.24256050
13	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	2.19482072
14	PPAR signaling pathway_Homo sapiens_hsa03320	2.13277741
15	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.12191654
16	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.06435884
17	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.96367149
18	Arginine biosynthesis_Homo sapiens_hsa00220	1.94812833
19	Bile secretion_Homo sapiens_hsa04976	1.92504669
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.89353708
21	beta-Alanine metabolism_Homo sapiens_hsa00410	1.81286318
22	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.79676587
23	Butanoate metabolism_Homo sapiens_hsa00650	1.79565484
24	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.72799139
25	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	1.68673740
26	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.64694229
27	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.61227176
28	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59725491
29	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.44429028
30	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.34170064
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.31344397
32	ABC transporters_Homo sapiens_hsa02010	1.28888433
33	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.28399576
34	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.26393275
35	Peroxisome_Homo sapiens_hsa04146	1.21665197
36	Fat digestion and absorption_Homo sapiens_hsa04975	1.13245319
37	Propanoate metabolism_Homo sapiens_hsa00640	1.06296928
38	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04978944
39	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.01222595
40	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98259632
41	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.98243490
42	Glycerolipid metabolism_Homo sapiens_hsa00561	0.95791965
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.91012891
44	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.90005965
45	Prion diseases_Homo sapiens_hsa05020	0.83486316
46	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.75205860
47	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.70085579
48	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.69384979
49	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.69153319
50	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.65746296
51	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.60103409
52	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.59016786
53	Other glycan degradation_Homo sapiens_hsa00511	0.58993090
54	Mineral absorption_Homo sapiens_hsa04978	0.58097194
55	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.57513865
56	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.51858270
57	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.51620812
58	Pertussis_Homo sapiens_hsa05133	0.47059126
59	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.47039256
60	Insulin resistance_Homo sapiens_hsa04931	0.46489090
61	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.44295750
62	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.44253470
63	Lysine degradation_Homo sapiens_hsa00310	0.42533322
64	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.42306478
65	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.40649510
66	Renin-angiotensin system_Homo sapiens_hsa04614	0.39902623
67	Carbon metabolism_Homo sapiens_hsa01200	0.38758869
68	Nitrogen metabolism_Homo sapiens_hsa00910	0.32833126
69	Fatty acid elongation_Homo sapiens_hsa00062	0.29541354
70	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.27072681
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.25915806
72	Glutathione metabolism_Homo sapiens_hsa00480	0.25285592
73	Renin secretion_Homo sapiens_hsa04924	0.24908182
74	Lysosome_Homo sapiens_hsa04142	0.24466809
75	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.24222392
76	Sphingolipid metabolism_Homo sapiens_hsa00600	0.24057927
77	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.23501670
78	Sulfur metabolism_Homo sapiens_hsa00920	0.23183152
79	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.22943485
80	AMPK signaling pathway_Homo sapiens_hsa04152	0.22477787
81	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.21155673
82	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.19222763
83	Gastric acid secretion_Homo sapiens_hsa04971	0.18620242
84	Pancreatic secretion_Homo sapiens_hsa04972	0.18370450
85	Biosynthesis of amino acids_Homo sapiens_hsa01230	0.17967877
86	Glucagon signaling pathway_Homo sapiens_hsa04922	0.15521824
87	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.15409110
88	Metabolic pathways_Homo sapiens_hsa01100	0.15060032
89	Choline metabolism in cancer_Homo sapiens_hsa05231	0.13682307
90	Serotonergic synapse_Homo sapiens_hsa04726	0.13220348
91	Salivary secretion_Homo sapiens_hsa04970	0.11163003
92	Ether lipid metabolism_Homo sapiens_hsa00565	0.10668276
93	Insulin signaling pathway_Homo sapiens_hsa04910	0.09374586
94	Leishmaniasis_Homo sapiens_hsa05140	0.09100135
95	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.07655243
96	Asthma_Homo sapiens_hsa05310	0.05753438
97	Osteoclast differentiation_Homo sapiens_hsa04380	0.04982888
98	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.04784046
99	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.04723316
100	Hepatitis C_Homo sapiens_hsa05160	0.04696710

METTL7A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »