ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	L-phenylalanine catabolic process (GO:0006559)	7.57192847
2	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	7.57192847
3	cellular response to leptin stimulus (GO:0044320)	7.30709168
4	L-phenylalanine metabolic process (GO:0006558)	7.25429447
5	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	7.25429447
6	fatty acid elongation (GO:0030497)	6.92734750
7	aromatic amino acid family catabolic process (GO:0009074)	6.86560236
8	regulation of cilium movement (GO:0003352)	6.40073593
9	indole-containing compound catabolic process (GO:0042436)	6.23051131
10	indolalkylamine catabolic process (GO:0046218)	6.23051131
11	tryptophan catabolic process (GO:0006569)	6.23051131
12	very long-chain fatty acid metabolic process (GO:0000038)	6.10101727
13	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	6.04221938
14	kynurenine metabolic process (GO:0070189)	6.01113831
15	response to leptin (GO:0044321)	5.98332405
16	artery smooth muscle contraction (GO:0014824)	5.90808849
17	bile acid biosynthetic process (GO:0006699)	5.87467016
18	glyoxylate metabolic process (GO:0046487)	5.86123753
19	tryptophan metabolic process (GO:0006568)	5.85517910
20	urea metabolic process (GO:0019627)	5.55996825
21	urea cycle (GO:0000050)	5.55996825
22	sulfur amino acid catabolic process (GO:0000098)	5.53511176
23	alpha-linolenic acid metabolic process (GO:0036109)	5.51678243
24	cysteine metabolic process (GO:0006534)	5.48730432
25	high-density lipoprotein particle remodeling (GO:0034375)	5.31500415
26	negative regulation of fibrinolysis (GO:0051918)	5.30567702
27	epoxygenase P450 pathway (GO:0019373)	5.25677452
28	serine family amino acid catabolic process (GO:0009071)	5.17403697
29	tonic smooth muscle contraction (GO:0014820)	5.16957700
30	complement activation, alternative pathway (GO:0006957)	5.16445506
31	protein carboxylation (GO:0018214)	5.13202601
32	peptidyl-glutamic acid carboxylation (GO:0017187)	5.13202601
33	nitrogen cycle metabolic process (GO:0071941)	5.12593771
34	regulation of fibrinolysis (GO:0051917)	5.10137463
35	negative regulation of appetite (GO:0032099)	5.08215830
36	negative regulation of response to food (GO:0032096)	5.08215830
37	regulation of protein activation cascade (GO:2000257)	5.07573600
38	alkaloid metabolic process (GO:0009820)	5.04953870
39	bile acid metabolic process (GO:0008206)	5.04277674
40	C4-dicarboxylate transport (GO:0015740)	5.00815383
41	aromatic amino acid family metabolic process (GO:0009072)	4.99033269
42	fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)	4.95652398
43	homocysteine metabolic process (GO:0050667)	4.94835013
44	regulation of cardiac muscle cell contraction (GO:0086004)	4.86821373
45	linoleic acid metabolic process (GO:0043651)	4.85201640
46	lysine metabolic process (GO:0006553)	4.81647352
47	lysine catabolic process (GO:0006554)	4.81647352
48	tyrosine metabolic process (GO:0006570)	4.76896512
49	ovulation cycle (GO:0042698)	4.76199686
50	regulation of complement activation (GO:0030449)	4.75458765
51	regulation of triglyceride catabolic process (GO:0010896)	4.72010410
52	cellular ketone body metabolic process (GO:0046950)	4.71059011
53	omega-hydroxylase P450 pathway (GO:0097267)	4.69841702
54	alpha-amino acid catabolic process (GO:1901606)	4.65917248
55	regulation of cholesterol esterification (GO:0010872)	4.65873462
56	amino-acid betaine metabolic process (GO:0006577)	4.65357069
57	drug metabolic process (GO:0017144)	4.61417724
58	reverse cholesterol transport (GO:0043691)	4.60920920
59	lipopolysaccharide biosynthetic process (GO:0009103)	4.57460504
60	protein-lipid complex remodeling (GO:0034368)	4.56338229
61	macromolecular complex remodeling (GO:0034367)	4.56338229
62	plasma lipoprotein particle remodeling (GO:0034369)	4.56338229
63	negative regulation of cholesterol transport (GO:0032375)	4.54037920
64	negative regulation of sterol transport (GO:0032372)	4.54037920
65	bile acid and bile salt transport (GO:0015721)	4.50329051
66	acylglycerol homeostasis (GO:0055090)	4.48509489
67	triglyceride homeostasis (GO:0070328)	4.48509489
68	nonmotile primary cilium assembly (GO:0035058)	4.43928131
69	indolalkylamine metabolic process (GO:0006586)	4.40782882
70	phospholipid efflux (GO:0033700)	4.40768372
71	cellular glucuronidation (GO:0052695)	4.38973266
72	coenzyme catabolic process (GO:0009109)	4.37089919
73	cellular amino acid catabolic process (GO:0009063)	4.32528887
74	glycine metabolic process (GO:0006544)	4.32012384
75	cellular biogenic amine catabolic process (GO:0042402)	4.30747157
76	amine catabolic process (GO:0009310)	4.30747157
77	signal peptide processing (GO:0006465)	4.28228762
78	glutamate metabolic process (GO:0006536)	4.26566036
79	serine family amino acid metabolic process (GO:0009069)	4.23835076
80	drug catabolic process (GO:0042737)	4.21632429
81	striatum development (GO:0021756)	4.21347260
82	benzene-containing compound metabolic process (GO:0042537)	4.19090977
83	plasma lipoprotein particle clearance (GO:0034381)	4.18104464
84	imidazole-containing compound metabolic process (GO:0052803)	4.16919732
85	regulation of vascular endothelial growth factor signaling pathway (GO:1900746)	4.15317717
86	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	4.14946767
87	cellular modified amino acid catabolic process (GO:0042219)	4.14604210
88	fat-soluble vitamin biosynthetic process (GO:0042362)	4.08630447
89	ethanol oxidation (GO:0006069)	4.08333308
90	ketone body metabolic process (GO:1902224)	4.08061573
91	regulation of protein glycosylation (GO:0060049)	4.06818094
92	neurotransmitter uptake (GO:0001504)	4.03410723
93	serine family amino acid biosynthetic process (GO:0009070)	4.01534471
94	regulation of response to food (GO:0032095)	4.00625464
95	cholesterol efflux (GO:0033344)	4.00065278
96	lipopolysaccharide metabolic process (GO:0008653)	4.00060402
97	dicarboxylic acid biosynthetic process (GO:0043650)	3.97923324
98	aldehyde catabolic process (GO:0046185)	3.96489972
99	arginine metabolic process (GO:0006525)	3.96250621
100	glucuronate metabolic process (GO:0019585)	3.92876285
101	uronic acid metabolic process (GO:0006063)	3.92876285
102	oxidative demethylation (GO:0070989)	3.89081385
103	short-chain fatty acid metabolic process (GO:0046459)	3.86544266
104	regulation of relaxation of muscle (GO:1901077)	3.83653508
105	fibrinolysis (GO:0042730)	3.83136720
106	plasma lipoprotein particle assembly (GO:0034377)	3.82337685
107	drug transmembrane transport (GO:0006855)	3.80650758
108	carboxylic acid catabolic process (GO:0046395)	3.80017834
109	organic acid catabolic process (GO:0016054)	3.80017834
110	low-density lipoprotein particle remodeling (GO:0034374)	3.79206228
111	regulation of bile acid biosynthetic process (GO:0070857)	3.78121895
112	L-amino acid import (GO:0043092)	3.77763058
113	acetyl-CoA metabolic process (GO:0006084)	3.77333933
114	brain morphogenesis (GO:0048854)	3.77320176
115	exogenous drug catabolic process (GO:0042738)	3.76971474
116	regulation of actin filament-based movement (GO:1903115)	3.76217223
117	cofactor catabolic process (GO:0051187)	3.72188167
118	regulation of cholesterol homeostasis (GO:2000188)	3.70558639
119	urate metabolic process (GO:0046415)	3.70219184
120	cholesterol homeostasis (GO:0042632)	3.67937764
121	flavonoid metabolic process (GO:0009812)	3.67885194
122	regulation of microtubule-based movement (GO:0060632)	3.67356273
123	phospholipid homeostasis (GO:0055091)	3.67007121
124	positive regulation of triglyceride lipase activity (GO:0061365)	3.66642744
125	positive regulation of lipoprotein lipase activity (GO:0051006)	3.66642744
126	sterol homeostasis (GO:0055092)	3.62722131
127	regulation of cholesterol biosynthetic process (GO:0045540)	3.62682781
128	positive regulation of lipid catabolic process (GO:0050996)	3.62444092
129	very-low-density lipoprotein particle assembly (GO:0034379)	3.62410846
130	negative regulation of lipase activity (GO:0060192)	3.61782985
131	blood coagulation, intrinsic pathway (GO:0007597)	3.60981510
132	vascular smooth muscle contraction (GO:0014829)	3.60210230
133	complement activation, classical pathway (GO:0006958)	3.59291287
134	complement activation (GO:0006956)	3.56234745
135	NAD biosynthetic process (GO:0009435)	3.55902398
136	aspartate family amino acid catabolic process (GO:0009068)	3.54730535
137	long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)	3.46131139
138	regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)	3.39704529
139	glutamine family amino acid biosynthetic process (GO:0009084)	3.38809804
140	xenobiotic catabolic process (GO:0042178)	3.37721096
141	fatty-acyl-CoA biosynthetic process (GO:0046949)	3.30950925
142	regulation of cell communication by electrical coupling (GO:0010649)	3.30307732
143	branched-chain amino acid catabolic process (GO:0009083)	3.28942161
144	hyperosmotic salinity response (GO:0042538)	3.25981663
145	response to misfolded protein (GO:0051788)	3.17363634
146	phenylpropanoid metabolic process (GO:0009698)	3.16195133
147	tricarboxylic acid cycle (GO:0006099)	3.15141549
148	respiratory tube development (GO:0030323)	3.14122126
149	renal absorption (GO:0070293)	3.12082413
150	one-carbon compound transport (GO:0019755)	3.10359884
151	tetrahydrofolate metabolic process (GO:0046653)	3.08738997
152	regulation of appetite (GO:0032098)	3.00293252
153	carnitine metabolic process (GO:0009437)	3.00099524
154	daunorubicin metabolic process (GO:0044597)	2.99791194
155	polyketide metabolic process (GO:0030638)	2.99791194
156	doxorubicin metabolic process (GO:0044598)	2.99791194
157	acyl-CoA biosynthetic process (GO:0071616)	2.99423311
158	thioester biosynthetic process (GO:0035384)	2.99423311
159	negative regulation of multicellular organism growth (GO:0040015)	2.99106278
160	regulation of cholesterol metabolic process (GO:0090181)	2.97818980
161	amino acid import (GO:0043090)	2.94596847

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	* RXR_22158963_ChIP-Seq_LIVER_Mouse	8.32069482
2	* PPARA_22158963_ChIP-Seq_LIVER_Mouse	7.14631101
3	* EGR1_23403033_ChIP-Seq_LIVER_Mouse	6.81575330
4	* LXR_22158963_ChIP-Seq_LIVER_Mouse	6.41978129
5	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	5.22259431
6	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	4.98590415
7	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	4.91866977
8	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	3.97214655
9	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	3.88108388
10	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.29901377
11	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.97409662
12	VDR_22108803_ChIP-Seq_LS180_Human	2.35103925
13	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22210163
14	ER_23166858_ChIP-Seq_MCF-7_Human	2.13928739
15	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	2.10904375
16	TCF7L2_21901280_ChIP-Seq_H4IIE_Rat	2.09173857
17	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.05886902
18	EZH2_22144423_ChIP-Seq_EOC_Human	2.03404953
19	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	11.7855427
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.75525851
21	ZNF274_21170338_ChIP-Seq_K562_Hela	1.66791701
22	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.58824805
23	CLOCK_20551151_ChIP-Seq_293T_Human	1.58612902
24	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.56166622
25	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	1.53621294
26	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.48533687
27	HTT_18923047_ChIP-ChIP_STHdh_Human	1.48490724
28	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.46883653
29	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.43690794
30	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.42959428
31	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.42681381
32	* HNF4A_19822575_ChIP-Seq_HepG2_Human	1.42266732
33	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.42192291
34	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.41658882
35	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.38204121
36	CJUN_26792858_Chip-Seq_BT549_Human	1.37026146
37	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.34825821
38	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.30141039
39	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28181645
40	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.27692839
41	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.26544533
42	GATA1_22025678_ChIP-Seq_K562_Human	1.25545457
43	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.23278154
44	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.20922571
45	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.17303943
46	* RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.16164422
47	TCF4_23295773_ChIP-Seq_U87_Human	1.15745368
48	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.12908866
49	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	1.10892211
50	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	1.10572401
51	FOXH1_21741376_ChIP-Seq_EPCs_Human	1.10512827
52	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.09834821
53	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	1.09325682
54	STAT3_23295773_ChIP-Seq_U87_Human	1.08668193
55	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.08537841
56	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.07672909
57	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.05577364
58	AR_25329375_ChIP-Seq_VCAP_Human	1.05433952
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.04404997
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.04404997
61	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.04381066
62	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.02511729
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.01732944
64	SOX2_19829295_ChIP-Seq_ESCs_Human	1.01732944
65	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.99206302
66	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	0.99206302
67	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	0.98669740
68	ESR1_15608294_ChIP-ChIP_MCF-7_Human	0.97661281
69	TCF4_22108803_ChIP-Seq_LS180_Human	0.95995049
70	JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.95903344
71	RARG_19884340_ChIP-ChIP_MEFs_Mouse	0.95342142
72	CTBP1_25329375_ChIP-Seq_LNCAP_Human	0.95265082
73	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.94499439
74	SMAD4_21799915_ChIP-Seq_A2780_Human	0.94348125
75	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.93880383
76	PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse	0.93504167
77	JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human	0.93477506
78	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.92974258
79	TCF4_18268006_ChIP-ChIP_LS174T_Human	0.92899413
80	GATA4_25053715_ChIP-Seq_YYC3_Human	0.91553245
81	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	0.90669852
82	OCT4_20526341_ChIP-Seq_ESCs_Human	0.90398752
83	CDX2_19796622_ChIP-Seq_MESCs_Mouse	0.85133079
84	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.84815887
85	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	0.83109276
86	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.82878630
87	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.82410709
88	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.82204906
89	ELK1_19687146_ChIP-ChIP_HELA_Human	0.82031726
90	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.81833759
91	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.80764664
92	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.80279293
93	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.79752315
94	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.79640430
95	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.79527385
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.79034514
97	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.78576152
98	STAT1_20625510_ChIP-Seq_HELA_Human	0.78274287
99	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.77947389
100	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	0.77921228
101	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.77791996
102	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.77759686
103	SREBP1_19666523_ChIP-Seq_LIVER_Mouse	0.77257907
104	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.75524998
105	ZNF263_19887448_ChIP-Seq_K562_Human	0.75109517
106	RARA_24833708_ChIP-Seq_LIVER_Mouse	0.74870912
107	NR0B1_18358816_ChIP-ChIP_MESCs_Mouse	0.73535447
108	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	0.71900848
109	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	0.70905073
110	CDX2_20551321_ChIP-Seq_CACO-2_Human	0.69845800
111	BMI1_19503595_ChIP-Seq_MEFsC_Mouse	0.69782378
112	* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.69617922
113	SALL4_18804426_ChIP-ChIP_XEN_Mouse	0.69225753
114	* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse	0.69031960
115	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	0.66130603
116	NRF2_20460467_ChIP-Seq_MEFs_Mouse	0.66130603
117	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.66118325
118	RARB_24833708_ChIP-Seq_LIVER_Mouse	0.63051898
119	EGR1_19032775_ChIP-ChIP_M12_Human	0.62886503
120	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	0.61768426
121	LXR_22292898_ChIP-Seq_THP-1_Human	0.59703145
122	ESR1_21235772_ChIP-Seq_MCF-7_Human	0.59613059
123	CEBPB_22108803_ChIP-Seq_LS180_Human	0.58534977
124	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	0.57539383
125	MYC_19915707_ChIP-ChIP_AK7_Human	0.56270238
126	STAT3_1855785_ChIP-Seq_MESCs_Mouse	0.56147049
127	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.55587138
128	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.55200271
129	AR_20517297_ChIP-Seq_VCAP_Human	0.51756388
130	GATA6_25053715_ChIP-Seq_YYC3_Human	0.51195541
131	ESET_19884257_ChIP-Seq_ESCs_Mouse	0.50142837
132	FOXO3_23340844_ChIP-Seq_DLD1_Human	0.49442521
133	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.49150557
134	FOXA1_26743006_Chip-Seq_LNCaP-abl_Human	0.48606679
135	STAT1_17558387_ChIP-Seq_HELA_Human	0.47188613
136	PPAR_26484153_Chip-Seq_NCI-H1993_Human	0.47066394
137	P53_21459846_ChIP-Seq_SAOS-2_Human	0.46975768
138	CBP_21632823_ChIP-Seq_H3396_Human	0.46375530
139	TAF2_19829295_ChIP-Seq_ESCs_Human	0.46171653
140	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.46150971
141	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.45787220
142	FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human	0.45486396
143	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	0.44591594
144	SOX2_20726797_ChIP-Seq_SW620_Human	0.44293340
145	PPARG_20887899_ChIP-Seq_3T3-L1_Mouse	0.44120452
146	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.42812853
147	GATA2_19941826_ChIP-Seq_K562_Human	0.42424881
148	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.42084352
149	GATA1_19941826_ChIP-Seq_K562_Human	0.41563526
150	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.40905669
151	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.40019995
152	BCAT_22108803_ChIP-Seq_LS180_Human	0.39206211
153	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	0.39047729
154	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.37876842
155	MYC_27129775_Chip-Seq_CORNEA_Mouse	0.37728140
156	CDX2_22108803_ChIP-Seq_LS180_Human	0.36951999
157	GATA3_20176728_ChIP-ChIP_TSCs_Mouse	0.36811703
158	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.36810370
159	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.36796872
160	GATA3_24758297_ChIP-Seq_MCF-7_Human	0.36470924
161	CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.36392877
162	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	0.36188781
163	RACK7_27058665_Chip-Seq_MCF-7_Human	0.36067922
164	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.35335409

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002139_abnormal_hepatobiliary_system	8.28961316
2	MP0005360_urolithiasis	7.64491331
3	MP0005085_abnormal_gallbladder_physiolo	6.40355331
4	MP0005365_abnormal_bile_salt	6.12740715
5	MP0008875_abnormal_xenobiotic_pharmacok	5.22472875
6	MP0001984_abnormal_olfaction	5.03766869
7	MP0002736_abnormal_nociception_after	4.35482051
8	MP0003806_abnormal_nucleotide_metabolis	4.07415756
9	MP0003252_abnormal_bile_duct	3.97601808
10	MP0010329_abnormal_lipoprotein_level	3.46384154
11	MP0005423_abnormal_somatic_nervous	3.41518287
12	MP0009840_abnormal_foam_cell	3.13613444
13	MP0001968_abnormal_touch/_nociception	2.97194673
14	MP0005083_abnormal_biliary_tract	2.92634849
15	MP0005332_abnormal_amino_acid	2.90395662
16	MP0003195_calcinosis	2.86953993
17	MP0001666_abnormal_nutrient_absorption	2.64252009
18	MP0003880_abnormal_central_pattern	2.55526716
19	MP0004019_abnormal_vitamin_homeostasis	2.36329474
20	MP0003191_abnormal_cellular_cholesterol	2.32159954
21	MP0002138_abnormal_hepatobiliary_system	2.12665996
22	MP0000609_abnormal_liver_physiology	2.11225676
23	MP0002118_abnormal_lipid_homeostasis	2.08033899
24	MP0005551_abnormal_eye_electrophysiolog	1.98685537
25	MP0003868_abnormal_feces_composition	1.93769460
26	MP0005319_abnormal_enzyme/_coenzyme	1.83004989
27	MP0002734_abnormal_mechanical_nocicepti	1.82590759
28	MP0003183_abnormal_peptide_metabolism	1.74607288
29	MP0005310_abnormal_salivary_gland	1.73064697
30	MP0000751_myopathy	1.70398573
31	MP0004215_abnormal_myocardial_fiber	1.67154261
32	MP0001764_abnormal_homeostasis	1.64154538
33	MP0001486_abnormal_startle_reflex	1.62102777
34	MP0005584_abnormal_enzyme/coenzyme_acti	1.58466469
35	MP0004147_increased_porphyrin_level	1.56692972
36	MP0005451_abnormal_body_composition	1.53179661
37	MP0001986_abnormal_taste_sensitivity	1.51723658
38	MP0009643_abnormal_urine_homeostasis	1.42702045
39	MP0009697_abnormal_copulation	1.40007770
40	MP0003186_abnormal_redox_activity	1.30724647
41	MP0003011_delayed_dark_adaptation	1.30513712
42	MP0000538_abnormal_urinary_bladder	1.24037370
43	MP0001905_abnormal_dopamine_level	1.19337600
44	MP0003705_abnormal_hypodermis_morpholog	1.16257881
45	MP0001970_abnormal_pain_threshold	1.15992058
46	MP0000749_muscle_degeneration	1.14883601
47	MP0000598_abnormal_liver_morphology	1.14574361
48	MP0003656_abnormal_erythrocyte_physiolo	1.12240660
49	MP0001853_heart_inflammation	1.11462114
50	MP0005647_abnormal_sex_gland	1.09114903
51	MP0005636_abnormal_mineral_homeostasis	1.08162535
52	MP0008260_abnormal_autophagy	1.07487541
53	MP0009764_decreased_sensitivity_to	1.02764052
54	MP0000343_altered_response_to	1.01962760
55	MP0003136_yellow_coat_color	1.00636132
56	MP0000604_amyloidosis	0.99019091
57	MP0004233_abnormal_muscle_weight	0.96301144
58	MP0004272_abnormal_basement_membrane	0.96027419
59	MP0009763_increased_sensitivity_to	0.95040771
60	MP0002254_reproductive_system_inflammat	0.92178465
61	MP0008775_abnormal_heart_ventricle	0.89515309
62	MP0008469_abnormal_protein_level	0.87325013
63	MP0009642_abnormal_blood_homeostasis	0.87276750
64	MP0005253_abnormal_eye_physiology	0.85834995
65	MP0005670_abnormal_white_adipose	0.84657416
66	MP0006036_abnormal_mitochondrial_physio	0.83498405
67	MP0005084_abnormal_gallbladder_morpholo	0.83399641
68	MP0002876_abnormal_thyroid_physiology	0.82107357
69	MP0005408_hypopigmentation	0.80656360
70	MP0002653_abnormal_ependyma_morphology	0.80008102
71	MP0002272_abnormal_nervous_system	0.79277531
72	MP0008789_abnormal_olfactory_epithelium	0.79204541
73	MP0010368_abnormal_lymphatic_system	0.78791501
74	MP0005376_homeostasis/metabolism_phenot	0.77290124
75	MP0001756_abnormal_urination	0.75936511
76	MP0002078_abnormal_glucose_homeostasis	0.75272922
77	MP0009765_abnormal_xenobiotic_induced	0.75210781
78	MP0005023_abnormal_wound_healing	0.75072604
79	MP0001485_abnormal_pinna_reflex	0.73019870
80	MP0002822_catalepsy	0.72004290
81	MP0005220_abnormal_exocrine_pancreas	0.70899313
82	MP0002733_abnormal_thermal_nociception	0.70750303
83	MP0002971_abnormal_brown_adipose	0.69507226
84	MP0004036_abnormal_muscle_relaxation	0.68198478
85	MP0005535_abnormal_body_temperature	0.67262119
86	MP0005334_abnormal_fat_pad	0.65929820
87	MP0004130_abnormal_muscle_cell	0.64823119
88	MP0009053_abnormal_anal_canal	0.64776584
89	MP0003633_abnormal_nervous_system	0.64582030
90	MP0001661_extended_life_span	0.64320033
91	MP0005266_abnormal_metabolism	0.63718158
92	MP0003690_abnormal_glial_cell	0.61379711
93	MP0001664_abnormal_digestion	0.60981520
94	MP0002136_abnormal_kidney_physiology	0.59992894
95	MP0001529_abnormal_vocalization	0.59268774
96	MP0002090_abnormal_vision	0.58239984
97	MP0003329_amyloid_beta_deposits	0.58184670
98	MP0004270_analgesia	0.57813461
99	MP0006035_abnormal_mitochondrial_morpho	0.57441722
100	MP0001963_abnormal_hearing_physiology	0.56216617
101	MP0002132_abnormal_respiratory_system	0.55878326
102	MP0008058_abnormal_DNA_repair	0.55670255
103	MP0005448_abnormal_energy_balance	0.52489653
104	MP0002928_abnormal_bile_duct	0.51518634
105	MP0000639_abnormal_adrenal_gland	0.51479547
106	MP0005164_abnormal_response_to	0.50451316
107	MP0005395_other_phenotype	0.49095746
108	MP0004043_abnormal_pH_regulation	0.48806524
109	MP0003638_abnormal_response/metabolism_	0.48540332
110	MP0010234_abnormal_vibrissa_follicle	0.46477370
111	MP0008873_increased_physiological_sensi	0.45062057
112	MP0003718_maternal_effect	0.44410432
113	MP0005464_abnormal_platelet_physiology	0.44366902
114	MP0002796_impaired_skin_barrier	0.43329006
115	MP0005666_abnormal_adipose_tissue	0.42787351
116	MP0008874_decreased_physiological_sensi	0.42388513
117	MP0003724_increased_susceptibility_to	0.42271758
118	MP0004782_abnormal_surfactant_physiolog	0.41687065
119	MP0003953_abnormal_hormone_level	0.41224908
120	MP0005166_decreased_susceptibility_to	0.40418622
121	MP0003075_altered_response_to	0.39421699
122	MP0001765_abnormal_ion_homeostasis	0.38662517
123	MP0008872_abnormal_physiological_respon	0.38455716
124	MP0000230_abnormal_systemic_arterial	0.38184825
125	MP0003436_decreased_susceptibility_to	0.36914528
126	MP0002837_dystrophic_cardiac_calcinosis	0.36336753
127	MP0009672_abnormal_birth_weight	0.35999841
128	MP0009384_cardiac_valve_regurgitation	0.35754381
129	MP0005248_abnormal_Harderian_gland	0.35098224
130	MP0002168_other_aberrant_phenotype	0.34746526
131	MP0005058_abnormal_lysosome_morphology	0.34645553
132	MP0004381_abnormal_hair_follicle	0.33850403
133	MP0004264_abnormal_extraembryonic_tissu	0.33215389
134	MP0000579_abnormal_nail_morphology	0.32220555
135	MP0005167_abnormal_blood-brain_barrier	0.32155357
136	MP0009115_abnormal_fat_cell	0.30612449
137	MP0000249_abnormal_blood_vessel	0.29449733
138	MP0006082_CNS_inflammation	0.28897903
139	MP0001845_abnormal_inflammatory_respons	0.28769725
140	MP0002970_abnormal_white_adipose	0.28054354
141	MP0001243_abnormal_dermal_layer	0.27051564
142	MP0004883_abnormal_blood_vessel	0.26857980

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of aromatic amino acid family metabolism (HP:0004338)	7.35913681
2	Intrahepatic cholestasis (HP:0001406)	7.17435903
3	Deep venous thrombosis (HP:0002625)	7.07195954
4	Abnormality of monocarboxylic acid metabolism (HP:0010996)	6.61608968
5	Hypobetalipoproteinemia (HP:0003563)	6.22030012
6	Prolonged partial thromboplastin time (HP:0003645)	6.21095080
7	Xanthomatosis (HP:0000991)	6.18600883
8	Hyperlipoproteinemia (HP:0010980)	5.43206861
9	Congenital primary aphakia (HP:0007707)	5.19941955
10	Complement deficiency (HP:0004431)	5.12217474
11	Gait imbalance (HP:0002141)	5.10047708
12	Hyperammonemia (HP:0001987)	4.65815572
13	Hypolipoproteinemia (HP:0010981)	4.63384966
14	Joint hemorrhage (HP:0005261)	4.56400560
15	Nephrogenic diabetes insipidus (HP:0009806)	4.54739983
16	Medial flaring of the eyebrow (HP:0010747)	4.52271496
17	Hyperglycinemia (HP:0002154)	4.43629141
18	Epidermoid cyst (HP:0200040)	4.42846980
19	Abnormality of glutamine family amino acid metabolism (HP:0010902)	4.42308602
20	Ketosis (HP:0001946)	4.35211634
21	Abnormality of sulfur amino acid metabolism (HP:0004339)	4.29990098
22	Abnormality of aspartate family amino acid metabolism (HP:0010899)	4.24955722
23	Abnormality of the level of lipoprotein cholesterol (HP:0010979)	4.23652999
24	Abnormality of methionine metabolism (HP:0010901)	4.19915354
25	Abnormality of the common coagulation pathway (HP:0010990)	4.14938870
26	Hyperglycinuria (HP:0003108)	4.14818971
27	Fat malabsorption (HP:0002630)	4.06824340
28	Hypoalphalipoproteinemia (HP:0003233)	4.05128578
29	Abnormality of glycine metabolism (HP:0010895)	4.04712819
30	Abnormality of serine family amino acid metabolism (HP:0010894)	4.04712819
31	Hypoglycemic coma (HP:0001325)	3.82947234
32	Poor coordination (HP:0002370)	3.82394734
33	Hemiplegia (HP:0002301)	3.79930272
34	Abnormality of pyrimidine metabolism (HP:0004353)	3.76772806
35	Abnormality of complement system (HP:0005339)	3.72940813
36	Conjugated hyperbilirubinemia (HP:0002908)	3.67357297
37	Abnormality of the intrinsic pathway (HP:0010989)	3.54069035
38	Abnormality of fatty-acid metabolism (HP:0004359)	3.50121128
39	Hypercholesterolemia (HP:0003124)	3.45684194
40	Action tremor (HP:0002345)	3.45548451
41	Abnormality of glycolysis (HP:0004366)	3.44418057
42	Vaginal atresia (HP:0000148)	3.43817185
43	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	3.38428416
44	Genital tract atresia (HP:0001827)	3.30957385
45	Hyperbilirubinemia (HP:0002904)	3.28401679
46	Abnormality of nucleobase metabolism (HP:0010932)	3.21684206
47	Ketoacidosis (HP:0001993)	3.14754201
48	Delayed CNS myelination (HP:0002188)	3.12913628
49	Abnormality of serum amino acid levels (HP:0003112)	3.05786296
50	Steatorrhea (HP:0002570)	3.05509892
51	Increased serum pyruvate (HP:0003542)	2.98184585
52	Hepatocellular carcinoma (HP:0001402)	2.95511472
53	Aplasia/Hypoplasia of the lens (HP:0008063)	2.95256850
54	Abnormality of purine metabolism (HP:0004352)	2.94139907
55	Gout (HP:0001997)	2.92431839
56	Bile duct proliferation (HP:0001408)	2.89720324
57	Abnormal biliary tract physiology (HP:0012439)	2.89720324
58	Left ventricular hypertrophy (HP:0001712)	2.88567830
59	Metabolic acidosis (HP:0001942)	2.86592233
60	Myocardial infarction (HP:0001658)	2.83386674
61	Spontaneous abortion (HP:0005268)	2.80356841
62	Hemiparesis (HP:0001269)	2.80089381
63	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.77811661
64	Dicarboxylic aciduria (HP:0003215)	2.77811661
65	CNS demyelination (HP:0007305)	2.73901970
66	Hepatocellular necrosis (HP:0001404)	2.72983187
67	Lethargy (HP:0001254)	2.72257760
68	Hypochromic microcytic anemia (HP:0004840)	2.71993557
69	Skin nodule (HP:0200036)	2.69953024
70	Vascular calcification (HP:0004934)	2.67491173
71	Systemic lupus erythematosus (HP:0002725)	2.64260953
72	Cerebral edema (HP:0002181)	2.49946954
73	Hepatic necrosis (HP:0002605)	2.46419865
74	Spastic diplegia (HP:0001264)	2.45452049
75	Irritability (HP:0000737)	2.43946739
76	Acanthocytosis (HP:0001927)	2.43663534
77	Neonatal onset (HP:0003623)	2.41286803
78	Hypoglycemic seizures (HP:0002173)	2.40277111
79	Abnormality of vitamin metabolism (HP:0100508)	2.37447420
80	Malnutrition (HP:0004395)	2.37412092
81	Cardiovascular calcification (HP:0011915)	2.36912253
82	Methylmalonic aciduria (HP:0012120)	2.36859661
83	Abnormal gallbladder morphology (HP:0012437)	2.36009738
84	Tetraplegia (HP:0002445)	2.35261058
85	Broad foot (HP:0001769)	2.34307052
86	Mitral stenosis (HP:0001718)	2.32412660
87	Cholecystitis (HP:0001082)	2.30466781
88	Abnormal gallbladder physiology (HP:0012438)	2.30466781
89	Cholelithiasis (HP:0001081)	2.29591948
90	Glomerulonephritis (HP:0000099)	2.28357556
91	Generalized aminoaciduria (HP:0002909)	2.27737918
92	Sensorimotor neuropathy (HP:0007141)	2.24784998
93	Alkalosis (HP:0001948)	2.24382660
94	Confusion (HP:0001289)	2.23735964
95	Nephritis (HP:0000123)	2.22002309
96	Enlarged kidneys (HP:0000105)	2.20726196
97	Abnormality of the vitamin B12 metabolism (HP:0004341)	2.20026771
98	Recurrent gram-negative bacterial infections (HP:0005420)	2.19540786
99	Exercise-induced myalgia (HP:0003738)	2.19452553
100	Vomiting (HP:0002013)	2.19268749
101	Esophageal varix (HP:0002040)	2.18338970
102	Late onset (HP:0003584)	2.18323979
103	Pancreatitis (HP:0001733)	2.17942761
104	Amyloidosis (HP:0011034)	2.13193281
105	Insidious onset (HP:0003587)	2.12562879
106	Termporal pattern (HP:0011008)	2.12562879
107	Brushfield spots (HP:0001088)	2.11653208
108	Rickets (HP:0002748)	2.10113806
109	Methylmalonic acidemia (HP:0002912)	2.09273178
110	Abnormal glucose tolerance (HP:0001952)	2.05700665
111	Abnormal cartilage morphology (HP:0002763)	2.05193632
112	Abnormality of proline metabolism (HP:0010907)	2.04865048
113	Hydroxyprolinuria (HP:0003080)	2.04865048
114	Ulnar claw (HP:0001178)	2.04409861
115	Hyperuricemia (HP:0002149)	2.03264068
116	Increased purine levels (HP:0004368)	2.03264068
117	Proximal tubulopathy (HP:0000114)	2.03241014
118	Type I transferrin isoform profile (HP:0003642)	2.02958859
119	Menorrhagia (HP:0000132)	2.02580838
120	Gingival bleeding (HP:0000225)	2.02518399
121	Abnormality of vitamin B metabolism (HP:0004340)	2.00713967
122	Opisthotonus (HP:0002179)	1.99487775
123	Thrombophlebitis (HP:0004418)	1.98026101
124	Abnormality of the gallbladder (HP:0005264)	1.96297701
125	Abnormal enzyme/coenzyme activity (HP:0012379)	1.93717364
126	Hyperinsulinemic hypoglycemia (HP:0000825)	1.92521051
127	Azoospermia (HP:0000027)	1.90039498
128	Glycosuria (HP:0003076)	1.89700346
129	Abnormality of urine glucose concentration (HP:0011016)	1.89700346
130	Hemorrhage of the eye (HP:0011885)	1.89339367
131	Hypophosphatemic rickets (HP:0004912)	1.88779932
132	Acute encephalopathy (HP:0006846)	1.88376057
133	Spastic tetraparesis (HP:0001285)	1.87942272
134	Poikilocytosis (HP:0004447)	1.87141552
135	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.85675312
136	Renal cortical cysts (HP:0000803)	1.84982219
137	Abnormality of iron homeostasis (HP:0011031)	1.82475956
138	Abnormality of transition element cation homeostasis (HP:0011030)	1.81811716
139	Fatigue (HP:0012378)	1.74351468
140	Mitochondrial inheritance (HP:0001427)	1.72064517
141	Large for gestational age (HP:0001520)	1.71679987
142	Abnormality of the vocal cords (HP:0008777)	1.71054543
143	Abnormal spermatogenesis (HP:0008669)	1.70082859

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PDK2	9.62758703
2	BCKDK	7.16182227
3	FGFR4	4.37930485
4	ERN1	4.26907336
5	SIK1	4.25035407
6	TAOK3	3.48379633
7	STK16	3.26283412
8	CCNB1	3.03360787
9	EIF2AK1	2.98304929
10	ERBB4	2.85776759
11	INSRR	2.83276611
12	MST1R	2.65704563
13	NEK6	2.33294940
14	MUSK	2.31670947
15	SRPK1	2.26045719
16	MAP2K4	2.17567504
17	PKN2	2.08742108
18	MAPK11	1.86014661
19	EIF2AK3	1.83530436
20	FLT3	1.69885680
21	FRK	1.68691198
22	PIK3CG	1.65524924
23	TNIK	1.64486533
24	TRIB3	1.62192743
25	LATS1	1.57153368
26	TYK2	1.54479404
27	ABL2	1.52982388
28	TNK2	1.48073886
29	PTK6	1.47356790
30	EPHA2	1.44424020
31	MAP3K7	1.37573962
32	DAPK2	1.32724235
33	NEK9	1.30564405
34	GRK6	1.27493020
35	STK38L	1.25627039
36	FGFR2	1.25412169
37	KDR	1.23931079
38	MKNK2	1.22289413
39	PRKAA2	1.16196137
40	TTK	1.14943310
41	JAK2	1.14405566
42	PINK1	1.11920809
43	CDK8	1.09300417
44	MAPKAPK3	1.09223103
45	TBK1	1.08128459
46	PTK2B	1.06527135
47	ERBB2	1.04593410
48	MAP3K14	1.02290718
49	BMPR1B	0.99663543
50	LMTK2	0.97220771
51	MET	0.97167504
52	MAP2K3	0.95937021
53	MAPK4	0.95306774
54	NTRK2	0.91908033
55	PIK3CA	0.91759257
56	MAPK15	0.91659565
57	PRKCZ	0.91191514
58	JAK1	0.88134187
59	PRKCE	0.86675754
60	MAP3K10	0.86511691
61	GRK7	0.86231835
62	MAP3K3	0.85091614
63	EPHB1	0.84042646
64	PLK2	0.82233545
65	RIPK1	0.80051627
66	PRKG2	0.76388617
67	TIE1	0.75893684
68	PRKACG	0.74998987
69	CAMK2G	0.74971766
70	MAPK12	0.74501831
71	LIMK1	0.74484704
72	CAMK2B	0.73734370
73	GSK3A	0.73371253
74	CAMK2D	0.73256234
75	CSK	0.72678269
76	MAP3K11	0.72157577
77	DYRK1B	0.71388350
78	MAP2K6	0.69943225
79	PRKAA1	0.69190258
80	SGK3	0.69099217
81	CDK6	0.68911126
82	PRKACB	0.68839109
83	CAMK1D	0.66481250
84	WNK4	0.65444262
85	FER	0.64038250
86	PRKACA	0.63723860
87	PTK2	0.63393775
88	PDPK1	0.63221293
89	VRK2	0.62755638
90	WNK3	0.59616477
91	IRAK3	0.57837243
92	EPHA3	0.57835252
93	MAP2K2	0.57536529
94	NME1	0.57393406
95	ERBB3	0.55658616
96	TGFBR2	0.55156533
97	IKBKE	0.54666984
98	MAPK7	0.52573203
99	CSNK2A1	0.51677098
100	RPS6KA5	0.50976027
101	PRKCQ	0.50839091
102	MAP2K1	0.50201884
103	SGK494	0.49729684
104	SGK223	0.49729684
105	EPHB2	0.48930033
106	SGK2	0.48568213
107	CSNK1G1	0.45310625
108	FGFR3	0.44991729
109	CSF1R	0.44386953
110	TRPM7	0.43326954
111	GRK1	0.42465334
112	PDK4	0.41634707
113	PDK3	0.41634707
114	MKNK1	0.40836498
115	IGF1R	0.40104183
116	ICK	0.39956276
117	PDK1	0.39420935
118	DYRK1A	0.39024558
119	SGK1	0.38668209
120	EPHA4	0.38128117
121	MAPKAPK5	0.37138824
122	PKN1	0.37040357
123	MAP3K13	0.36960826
124	OXSR1	0.36774739
125	CAMK2A	0.36747584
126	CLK1	0.36454283
127	TAOK2	0.36314494
128	FGR	0.35812062
129	AKT2	0.35548950
130	MAP3K5	0.34601884
131	PRKDC	0.34471857
132	PRKCG	0.33932471
133	STK10	0.32919907
134	MTOR	0.32079454
135	MAP3K1	0.32071107
136	PBK	0.31501159
137	RET	0.31315814
138	SRC	0.30976615
139	ADRBK1	0.30855104
140	PRKCA	0.30669514
141	PAK3	0.30390484
142	CSNK1D	0.29981294
143	MYLK	0.29804081
144	INSR	0.29313022
145	EGFR	0.29043955
146	CDK4	0.28746380
147	CSNK2A2	0.27324363
148	MAP3K2	0.27126619
149	LRRK2	0.26164796
150	CAMK4	0.25383798
151	NME2	0.25100685
152	OBSCN	0.24969662
153	ROCK2	0.24208900
154	PIM2	0.24050308
155	ADRBK2	0.23720854
156	MAP3K6	0.22868678
157	NEK1	0.21465161

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Primary bile acid biosynthesis_Homo sapiens_hsa00120	4.37860631
2	Nitrogen metabolism_Homo sapiens_hsa00910	3.44677027
3	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.41399189
4	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	3.32521641
5	Arginine biosynthesis_Homo sapiens_hsa00220	2.98508355
6	Tryptophan metabolism_Homo sapiens_hsa00380	2.70804243
7	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	2.66182346
8	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	2.64104333
9	Complement and coagulation cascades_Homo sapiens_hsa04610	2.57458419
10	Fatty acid degradation_Homo sapiens_hsa00071	2.50734282
11	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.50527758
12	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	2.44779550
13	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.33815251
14	Butanoate metabolism_Homo sapiens_hsa00650	2.28597269
15	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	2.13565344
16	Peroxisome_Homo sapiens_hsa04146	2.12256370
17	Propanoate metabolism_Homo sapiens_hsa00640	1.98335942
18	Chemical carcinogenesis_Homo sapiens_hsa05204	1.93730681
19	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.91912434
20	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.91022673
21	Histidine metabolism_Homo sapiens_hsa00340	1.90713217
22	PPAR signaling pathway_Homo sapiens_hsa03320	1.87893637
23	Fatty acid metabolism_Homo sapiens_hsa01212	1.82033316
24	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.80318437
25	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.72615294
26	beta-Alanine metabolism_Homo sapiens_hsa00410	1.72237985
27	Caffeine metabolism_Homo sapiens_hsa00232	1.69128725
28	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.68880388
29	Retinol metabolism_Homo sapiens_hsa00830	1.67045587
30	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	1.66097739
31	Sulfur metabolism_Homo sapiens_hsa00920	1.64252292
32	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.60870661
33	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.56903824
34	Phenylalanine metabolism_Homo sapiens_hsa00360	1.56785350
35	Bile secretion_Homo sapiens_hsa04976	1.55707506
36	Selenocompound metabolism_Homo sapiens_hsa00450	1.55561866
37	Pyruvate metabolism_Homo sapiens_hsa00620	1.43432004
38	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.41499824
39	Tyrosine metabolism_Homo sapiens_hsa00350	1.40792249
40	Fatty acid elongation_Homo sapiens_hsa00062	1.33011225
41	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.31407085
42	Starch and sucrose metabolism_Homo sapiens_hsa00500	1.30363797
43	Folate biosynthesis_Homo sapiens_hsa00790	1.21465863
44	Steroid biosynthesis_Homo sapiens_hsa00100	1.18738339
45	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.18189115
46	Carbon metabolism_Homo sapiens_hsa01200	1.16372963
47	ABC transporters_Homo sapiens_hsa02010	1.15487488
48	Fat digestion and absorption_Homo sapiens_hsa04975	1.14628835
49	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.11439866
50	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.09370622
51	Sulfur relay system_Homo sapiens_hsa04122	1.01830215
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.00580232
53	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.99843344
54	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.98171825
55	Arginine and proline metabolism_Homo sapiens_hsa00330	0.98140155
56	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.92830066
57	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.91279327
58	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.86627267
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.84674551
60	Lysine degradation_Homo sapiens_hsa00310	0.80447617
61	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.73349928
62	Glutathione metabolism_Homo sapiens_hsa00480	0.73039902
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.72656284
64	Glycerolipid metabolism_Homo sapiens_hsa00561	0.70025018
65	One carbon pool by folate_Homo sapiens_hsa00670	0.67393430
66	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.59810742
67	Pentose phosphate pathway_Homo sapiens_hsa00030	0.58218758
68	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.57940265
69	Proteasome_Homo sapiens_hsa03050	0.57842630
70	Metabolic pathways_Homo sapiens_hsa01100	0.47996910
71	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.47834821
72	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.42165728
73	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.31739572
74	Prion diseases_Homo sapiens_hsa05020	0.31241572
75	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.29200798
76	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.29026157
77	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.28982735
78	Galactose metabolism_Homo sapiens_hsa00052	0.28122624
79	Sphingolipid metabolism_Homo sapiens_hsa00600	0.27722185
80	Pancreatic secretion_Homo sapiens_hsa04972	0.26870264
81	Linoleic acid metabolism_Homo sapiens_hsa00591	0.23051705
82	Insulin resistance_Homo sapiens_hsa04931	0.21227564
83	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20986909
84	Oxidative phosphorylation_Homo sapiens_hsa00190	0.20940236
85	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.20547649
86	Other glycan degradation_Homo sapiens_hsa00511	0.20053403
87	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.16410859
88	Parkinsons disease_Homo sapiens_hsa05012	0.10381585
89	Collecting duct acid secretion_Homo sapiens_hsa04966	0.09583401
90	Glucagon signaling pathway_Homo sapiens_hsa04922	0.08426247
91	Pertussis_Homo sapiens_hsa05133	0.05198463
92	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.02559223
93	AMPK signaling pathway_Homo sapiens_hsa04152	0.01484738
94	Alzheimers disease_Homo sapiens_hsa05010	0.01139313
95	Homologous recombination_Homo sapiens_hsa03440	0.01062681
96	Glutamatergic synapse_Homo sapiens_hsa04724	0.00728337
97	Huntingtons disease_Homo sapiens_hsa05016	0.00111878
98	Bladder cancer_Homo sapiens_hsa05219	-0.2415451
99	Ether lipid metabolism_Homo sapiens_hsa00565	-0.2382599
100	Protein digestion and absorption_Homo sapiens_hsa04974	-0.2337160
101	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	-0.2286333
102	Systemic lupus erythematosus_Homo sapiens_hsa05322	-0.1760620
103	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	-0.1721193
104	Central carbon metabolism in cancer_Homo sapiens_hsa05230	-0.1696562
105	Hepatitis C_Homo sapiens_hsa05160	-0.1654334
106	African trypanosomiasis_Homo sapiens_hsa05143	-0.1652355
107	Thyroid hormone synthesis_Homo sapiens_hsa04918	-0.1642358
108	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	-0.1590843
109	Mineral absorption_Homo sapiens_hsa04978	-0.1537644
110	Regulation of autophagy_Homo sapiens_hsa04140	-0.1371137
111	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	-0.1308414
112	Renin-angiotensin system_Homo sapiens_hsa04614	-0.1304811
113	Glycosaminoglycan degradation_Homo sapiens_hsa00531	-0.1186910
114	Arachidonic acid metabolism_Homo sapiens_hsa00590	-0.1151317
115	Insulin signaling pathway_Homo sapiens_hsa04910	-0.1101968
116	Ovarian steroidogenesis_Homo sapiens_hsa04913	-0.0811985
117	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	-0.0314009
118	Nicotine addiction_Homo sapiens_hsa05033	-0.0182884

METTL7B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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