METTL8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1prenylation (GO:0097354)4.99689083
2protein prenylation (GO:0018342)4.99689083
3DNA deamination (GO:0045006)4.37920534
4DNA strand renaturation (GO:0000733)4.37190760
5fucose catabolic process (GO:0019317)4.35616304
6L-fucose metabolic process (GO:0042354)4.35616304
7L-fucose catabolic process (GO:0042355)4.35616304
8behavioral response to nicotine (GO:0035095)4.23176359
9folic acid-containing compound biosynthetic process (GO:0009396)4.01699018
10DNA replication initiation (GO:0006270)3.95888154
11regulation of posttranscriptional gene silencing (GO:0060147)3.94858562
12regulation of gene silencing by miRNA (GO:0060964)3.94858562
13regulation of gene silencing by RNA (GO:0060966)3.94858562
14telomere maintenance via semi-conservative replication (GO:0032201)3.94337390
15L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.80158931
16DNA strand elongation involved in DNA replication (GO:0006271)3.80061545
17DNA strand elongation (GO:0022616)3.71167488
18recombinational repair (GO:0000725)3.66447803
19double-strand break repair via homologous recombination (GO:0000724)3.65762992
20DNA double-strand break processing (GO:0000729)3.64503108
21pteridine-containing compound biosynthetic process (GO:0042559)3.61383709
22pseudouridine synthesis (GO:0001522)3.60028902
23water-soluble vitamin biosynthetic process (GO:0042364)3.56317936
24protein-cofactor linkage (GO:0018065)3.55935403
25cullin deneddylation (GO:0010388)3.52876869
26kinetochore assembly (GO:0051382)3.51270171
27regulation of DNA endoreduplication (GO:0032875)3.49450738
28kinetochore organization (GO:0051383)3.48249243
29tryptophan catabolic process (GO:0006569)3.47240470
30indole-containing compound catabolic process (GO:0042436)3.47240470
31indolalkylamine catabolic process (GO:0046218)3.47240470
32mitochondrial RNA metabolic process (GO:0000959)3.45913956
33maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.43469552
34telomere maintenance via recombination (GO:0000722)3.43330803
35mismatch repair (GO:0006298)3.43054646
36kynurenine metabolic process (GO:0070189)3.42744779
37negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.42404781
38negative regulation of DNA-dependent DNA replication (GO:2000104)3.41203103
39polyketide metabolic process (GO:0030638)3.38250626
40doxorubicin metabolic process (GO:0044598)3.38250626
41daunorubicin metabolic process (GO:0044597)3.38250626
42indolalkylamine metabolic process (GO:0006586)3.38202835
43V(D)J recombination (GO:0033151)3.35823643
44protein deneddylation (GO:0000338)3.35558249
45purine nucleobase biosynthetic process (GO:0009113)3.33733581
46telomere maintenance via telomere lengthening (GO:0010833)3.31907789
47replication fork processing (GO:0031297)3.31718372
48protoporphyrinogen IX biosynthetic process (GO:0006782)3.28034889
49detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.27578860
50mitotic recombination (GO:0006312)3.26105142
51synapsis (GO:0007129)3.25876917
52nucleobase biosynthetic process (GO:0046112)3.25698282
53IMP biosynthetic process (GO:0006188)3.24762290
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.23075376
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23075376
56positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23075376
57mitotic sister chromatid cohesion (GO:0007064)3.22940115
58establishment of integrated proviral latency (GO:0075713)3.20307304
59L-methionine salvage (GO:0071267)3.19040656
60L-methionine biosynthetic process (GO:0071265)3.19040656
61amino acid salvage (GO:0043102)3.19040656
62mitochondrial respiratory chain complex I assembly (GO:0032981)3.18756251
63NADH dehydrogenase complex assembly (GO:0010257)3.18756251
64mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.18756251
65preassembly of GPI anchor in ER membrane (GO:0016254)3.17151216
66proteasome assembly (GO:0043248)3.16388437
67DNA unwinding involved in DNA replication (GO:0006268)3.15709346
68meiotic chromosome segregation (GO:0045132)3.15418602
69negative regulation of RNA splicing (GO:0033119)3.14181844
70regulation of nuclear cell cycle DNA replication (GO:0033262)3.13854472
71tryptophan metabolic process (GO:0006568)3.13308194
72CENP-A containing nucleosome assembly (GO:0034080)3.12832326
73chromatin remodeling at centromere (GO:0031055)3.10775456
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.10080071
75methionine biosynthetic process (GO:0009086)3.09498976
76mitochondrial respiratory chain complex assembly (GO:0033108)3.05988049
77tetrahydrofolate metabolic process (GO:0046653)3.05651851
78protein complex biogenesis (GO:0070271)3.04740365
79snRNA processing (GO:0016180)3.04136267
80DNA demethylation (GO:0080111)3.04115909
81negative regulation of mRNA processing (GO:0050686)3.03786043
82somatic cell DNA recombination (GO:0016444)3.03549799
83somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.03549799
84RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.01411866
85protein K11-linked deubiquitination (GO:0035871)2.97448182
86respiratory chain complex IV assembly (GO:0008535)2.96454602
87telomere organization (GO:0032200)2.96025617
88methionine metabolic process (GO:0006555)2.95275397
89telomere maintenance (GO:0000723)2.94282461
90rRNA modification (GO:0000154)2.93346054
91negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.92820137
92negative regulation of translation, ncRNA-mediated (GO:0040033)2.92820137
93regulation of translation, ncRNA-mediated (GO:0045974)2.92820137
94spliceosomal snRNP assembly (GO:0000387)2.90612735
95oxidative demethylation (GO:0070989)2.89415651
96transcription-coupled nucleotide-excision repair (GO:0006283)2.88776220
97DNA replication checkpoint (GO:0000076)2.87982703
98heme biosynthetic process (GO:0006783)2.87381061
99rRNA methylation (GO:0031167)2.87299222
100somatic diversification of immune receptors (GO:0002200)2.85854770
101intra-S DNA damage checkpoint (GO:0031573)2.85771259
102pteridine-containing compound metabolic process (GO:0042558)2.84848065
103IMP metabolic process (GO:0046040)2.83660097
104protoporphyrinogen IX metabolic process (GO:0046501)2.83542897
105piRNA metabolic process (GO:0034587)2.83459167
106DNA synthesis involved in DNA repair (GO:0000731)2.83137107
107sulfation (GO:0051923)2.82060474
108viral mRNA export from host cell nucleus (GO:0046784)2.81549667
109ribosomal small subunit assembly (GO:0000028)2.81503277
110exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.81440998
111somatic diversification of immune receptors via somatic mutation (GO:0002566)2.81264949
112somatic hypermutation of immunoglobulin genes (GO:0016446)2.81264949
113double-strand break repair via nonhomologous end joining (GO:0006303)2.81103299
114non-recombinational repair (GO:0000726)2.81103299
115reciprocal meiotic recombination (GO:0007131)2.79404138
116reciprocal DNA recombination (GO:0035825)2.79404138
117tRNA aminoacylation for protein translation (GO:0006418)2.78448582
118regulation of hippo signaling (GO:0035330)2.78013388
119snRNA metabolic process (GO:0016073)2.76594715
120tRNA aminoacylation (GO:0043039)2.76553629
121amino acid activation (GO:0043038)2.76553629
122folic acid-containing compound metabolic process (GO:0006760)2.75488342
123somatic recombination of immunoglobulin gene segments (GO:0016447)2.75008379
124somatic diversification of immunoglobulins (GO:0016445)2.74829950
125protein K6-linked ubiquitination (GO:0085020)2.73999039
126histone H2A acetylation (GO:0043968)2.73786156
127tRNA modification (GO:0006400)2.72266258
128tRNA metabolic process (GO:0006399)2.72260813
129tRNA processing (GO:0008033)2.71828733
130pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.71433642
131platelet dense granule organization (GO:0060155)2.71162292
132sulfur amino acid biosynthetic process (GO:0000097)2.71031424
133positive regulation of histone H3-K4 methylation (GO:0051571)2.70342310
134tRNA methylation (GO:0030488)2.69835551
135signal peptide processing (GO:0006465)2.67652998
136nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.66914958
137maturation of 5.8S rRNA (GO:0000460)2.65592497
138histone mRNA metabolic process (GO:0008334)2.65411424
139termination of RNA polymerase III transcription (GO:0006386)2.64702892
140transcription elongation from RNA polymerase III promoter (GO:0006385)2.64702892
141DNA replication-independent nucleosome assembly (GO:0006336)2.64679363
142DNA replication-independent nucleosome organization (GO:0034724)2.64679363
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.61728978
144somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.61728978
145isotype switching (GO:0045190)2.61728978
146DNA geometric change (GO:0032392)2.61140222
147regulation of mitotic spindle checkpoint (GO:1903504)2.60833794
148regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.60833794
149cytochrome complex assembly (GO:0017004)2.60015427
150positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)2.59510063
151regulation of DNA damage checkpoint (GO:2000001)2.59488977
152ubiquinone biosynthetic process (GO:0006744)2.59327587
153histone exchange (GO:0043486)2.58302698
154regulation of meiosis I (GO:0060631)2.57689805
155RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.57172717
156tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.57172717
157rRNA catabolic process (GO:0016075)2.56292098
158protein polyglutamylation (GO:0018095)2.55007960
159regulation of mesoderm development (GO:2000380)2.54609516
160double-strand break repair (GO:0006302)2.51739977
161neural tube formation (GO:0001841)2.51636288
162kidney morphogenesis (GO:0060993)2.50951748
163DNA dealkylation (GO:0035510)2.50206865
164DNA catabolic process, exonucleolytic (GO:0000738)2.50034890
165ubiquinone metabolic process (GO:0006743)2.48555707
166detection of light stimulus involved in visual perception (GO:0050908)2.48379822
167detection of light stimulus involved in sensory perception (GO:0050962)2.48379822
168ncRNA catabolic process (GO:0034661)2.47559301
169mannosylation (GO:0097502)2.47079303
170negative regulation of telomere maintenance (GO:0032205)2.47032376

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.58126743
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.99813609
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.88555380
4NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.73100522
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.71996420
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.57241965
7ZNF274_21170338_ChIP-Seq_K562_Hela3.51986544
8VDR_22108803_ChIP-Seq_LS180_Human3.41171554
9EST1_17652178_ChIP-ChIP_JURKAT_Human3.01348494
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97586083
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.85597871
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.80891730
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.77786645
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.73614679
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.71851900
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.65971844
17SALL1_21062744_ChIP-ChIP_HESCs_Human2.62206321
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61268323
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.53897904
20HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.52979643
21GBX2_23144817_ChIP-Seq_PC3_Human2.48883237
22* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42377124
23* SRF_21415370_ChIP-Seq_HL-1_Mouse2.40849386
24* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.40522952
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.40512701
26FOXP3_21729870_ChIP-Seq_TREG_Human2.39935279
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.32714536
28ELF1_17652178_ChIP-ChIP_JURKAT_Human2.31317583
29FOXM1_23109430_ChIP-Seq_U2OS_Human2.24813091
30ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24407561
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.22699791
32VDR_23849224_ChIP-Seq_CD4+_Human2.19901917
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16330206
34MYC_19079543_ChIP-ChIP_MESCs_Mouse2.09572966
35CREB1_15753290_ChIP-ChIP_HEK293T_Human2.08994139
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.08273134
37POU3F2_20337985_ChIP-ChIP_501MEL_Human2.07387396
38TAF15_26573619_Chip-Seq_HEK293_Human2.04683650
39P300_19829295_ChIP-Seq_ESCs_Human1.92958974
40PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.92902441
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.91727677
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87352919
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.87286322
44PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.86551745
45SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.84724917
46* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.84464161
47PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.83450183
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82682453
49GABP_19822575_ChIP-Seq_HepG2_Human1.80753357
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.79630866
51FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.76930034
52* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76877540
53XRN2_22483619_ChIP-Seq_HELA_Human1.75130023
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.74640262
55PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74009761
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73380805
57DCP1A_22483619_ChIP-Seq_HELA_Human1.72711077
58MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.72196969
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65647643
60CTBP1_25329375_ChIP-Seq_LNCAP_Human1.65600392
61ELK1_19687146_ChIP-ChIP_HELA_Human1.62451718
62KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.62101236
63* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.60615232
64ER_23166858_ChIP-Seq_MCF-7_Human1.57444351
65EGR1_23403033_ChIP-Seq_LIVER_Mouse1.56426558
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.54766852
67IRF1_19129219_ChIP-ChIP_H3396_Human1.53796237
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53140631
69TTF2_22483619_ChIP-Seq_HELA_Human1.52648213
70* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52000408
71* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.50732454
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50691859
73EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.47190307
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.46932749
75CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.46792033
76CIITA_25753668_ChIP-Seq_RAJI_Human1.43454175
77BCAT_22108803_ChIP-Seq_LS180_Human1.43106665
78AR_21909140_ChIP-Seq_LNCAP_Human1.42180045
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.41412564
80STAT3_23295773_ChIP-Seq_U87_Human1.39036763
81KDM5A_27292631_Chip-Seq_BREAST_Human1.37429938
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37291823
83IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35245325
84CBP_20019798_ChIP-Seq_JUKART_Human1.35245325
85* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35082727
86SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.33395349
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30852661
88MYC_18940864_ChIP-ChIP_HL60_Human1.29884357
89MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.29586049
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.29353982
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29012990
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29012990
93POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27635486
94TP53_22573176_ChIP-Seq_HFKS_Human1.27613861
95NR3C1_21868756_ChIP-Seq_MCF10A_Human1.25194515
96MYC_22102868_ChIP-Seq_BL_Human1.24907384
97SCL_19346495_ChIP-Seq_HPC-7_Human1.24513033
98TCF4_23295773_ChIP-Seq_U87_Human1.22806111
99AR_21572438_ChIP-Seq_LNCaP_Human1.22258962
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20871797
101ZFX_18555785_ChIP-Seq_MESCs_Mouse1.20443153
102GATA1_22025678_ChIP-Seq_K562_Human1.20182304
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.19020733
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18527780
105SMAD4_21799915_ChIP-Seq_A2780_Human1.18044535
106TCF4_22108803_ChIP-Seq_LS180_Human1.17468354
107NANOG_19829295_ChIP-Seq_ESCs_Human1.16931983
108SOX2_19829295_ChIP-Seq_ESCs_Human1.16931983
109KLF5_20875108_ChIP-Seq_MESCs_Mouse1.15819191
110FOXA1_25329375_ChIP-Seq_VCAP_Human1.15626754
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.15626754
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14441345
113CRX_20693478_ChIP-Seq_RETINA_Mouse1.13851200
114ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.11496215
115TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08222715
116* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.07657726
117IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07328870
118PIAS1_25552417_ChIP-Seq_VCAP_Human1.06851896
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05291962
120GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.05031920
121* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.04681834
122* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04109397
123AR_25329375_ChIP-Seq_VCAP_Human1.03911809
124* NANOG_18555785_Chip-Seq_ESCs_Mouse1.01445330
125EWS_26573619_Chip-Seq_HEK293_Human1.01404302
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.01034907
127PCGF2_27294783_Chip-Seq_ESCs_Mouse1.00937786
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.00698005
129TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00228279
130SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00058964
131FOXA1_21572438_ChIP-Seq_LNCaP_Human0.99152233
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.98811489
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.98271582
134* P53_22387025_ChIP-Seq_ESCs_Mouse0.97589658
135OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96792011
136RUNX2_22187159_ChIP-Seq_PCA_Human0.96563306
137* P300_18555785_Chip-Seq_ESCs_Mouse0.96465971
138CDX2_22108803_ChIP-Seq_LS180_Human0.95840476
139SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95614795
140FUS_26573619_Chip-Seq_HEK293_Human0.94973403
141TP63_19390658_ChIP-ChIP_HaCaT_Human0.94898727
142FLI1_21867929_ChIP-Seq_TH2_Mouse0.94792423
143FLI1_27457419_Chip-Seq_LIVER_Mouse0.92057660
144CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.89901797
145NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88498800
146SALL4_22934838_ChIP-ChIP_CD34+_Human0.87402476
147ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87280459
148TFEB_21752829_ChIP-Seq_HELA_Human0.87095293
149MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.86337963
150SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85510624
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82683549
152HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.82594192
153IGF1R_20145208_ChIP-Seq_DFB_Human0.82578875
154SOX2_18555785_ChIP-Seq_MESCs_Mouse0.80545084
155POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79494825
156CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.77377563
157NFE2_27457419_Chip-Seq_LIVER_Mouse0.72990671
158CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.72282581
159BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.72074675
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71104062
161DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.70746508
162SOX17_20123909_ChIP-Seq_XEN_Mouse0.67431200
163* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.66358871
164SUZ12_27294783_Chip-Seq_NPCs_Mouse0.66229038
165FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.64686389
166* STAT3_18555785_Chip-Seq_ESCs_Mouse0.62910730
167SPI1_23547873_ChIP-Seq_NB4_Human0.62830561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.02886392
2MP0009697_abnormal_copulation3.34697066
3MP0008058_abnormal_DNA_repair3.28318557
4MP0002396_abnormal_hematopoietic_system3.17317834
5MP0003111_abnormal_nucleus_morphology3.13313911
6MP0004147_increased_porphyrin_level3.12175384
7MP0003693_abnormal_embryo_hatching2.96403451
8MP0003077_abnormal_cell_cycle2.80948407
9MP0000569_abnormal_digit_pigmentation2.75758984
10MP0003136_yellow_coat_color2.69175906
11MP0001529_abnormal_vocalization2.63870738
12MP0004957_abnormal_blastocyst_morpholog2.55583512
13MP0008057_abnormal_DNA_replication2.45676010
14MP0008877_abnormal_DNA_methylation2.44759250
15MP0006292_abnormal_olfactory_placode2.43374701
16MP0002139_abnormal_hepatobiliary_system2.35653768
17MP0003195_calcinosis2.34108050
18MP0005085_abnormal_gallbladder_physiolo2.33397376
19MP0002132_abnormal_respiratory_system2.33367854
20MP0001986_abnormal_taste_sensitivity2.31119208
21MP0005360_urolithiasis2.30457080
22MP0005551_abnormal_eye_electrophysiolog2.15919576
23MP0006072_abnormal_retinal_apoptosis2.14636485
24MP0008007_abnormal_cellular_replicative2.14213380
25MP0005171_absent_coat_pigmentation2.07968463
26MP0003656_abnormal_erythrocyte_physiolo2.06233536
27MP0003890_abnormal_embryonic-extraembry2.03491232
28MP0005365_abnormal_bile_salt2.01918772
29MP0006054_spinal_hemorrhage1.96602954
30MP0003646_muscle_fatigue1.96230161
31MP0005174_abnormal_tail_pigmentation1.92839690
32MP0005075_abnormal_melanosome_morpholog1.91393635
33MP0003787_abnormal_imprinting1.88167391
34MP0002102_abnormal_ear_morphology1.83022619
35MP0000372_irregular_coat_pigmentation1.80822221
36MP0005389_reproductive_system_phenotype1.79188033
37MP0003121_genomic_imprinting1.78838358
38MP0002837_dystrophic_cardiac_calcinosis1.74941122
39MP0002822_catalepsy1.73217451
40MP0008872_abnormal_physiological_respon1.72066914
41MP0001764_abnormal_homeostasis1.68689082
42MP0005253_abnormal_eye_physiology1.68434013
43MP0002160_abnormal_reproductive_system1.66744153
44MP0003937_abnormal_limbs/digits/tail_de1.66374111
45MP0001919_abnormal_reproductive_system1.66227932
46MP0008932_abnormal_embryonic_tissue1.63296583
47MP0000383_abnormal_hair_follicle1.62807570
48MP0003763_abnormal_thymus_physiology1.60193709
49MP0000490_abnormal_crypts_of1.56123506
50MP0002095_abnormal_skin_pigmentation1.53148246
51MP0005645_abnormal_hypothalamus_physiol1.51338439
52MP0002736_abnormal_nociception_after1.49341728
53MP0001485_abnormal_pinna_reflex1.48402509
54MP0000015_abnormal_ear_pigmentation1.45815763
55MP0000631_abnormal_neuroendocrine_gland1.44157419
56MP0003941_abnormal_skin_development1.43180662
57MP0003806_abnormal_nucleotide_metabolis1.42142007
58MP0001968_abnormal_touch/_nociception1.41746009
59MP0006036_abnormal_mitochondrial_physio1.39625479
60MP0003718_maternal_effect1.38122115
61MP0003123_paternal_imprinting1.33441400
62MP0002163_abnormal_gland_morphology1.33181301
63MP0002938_white_spotting1.32874966
64MP0004133_heterotaxia1.32591105
65MP0000427_abnormal_hair_cycle1.32495543
66MP0005646_abnormal_pituitary_gland1.29663304
67MP0001188_hyperpigmentation1.27931497
68MP0003868_abnormal_feces_composition1.27900724
69MP0001545_abnormal_hematopoietic_system1.26132540
70MP0005397_hematopoietic_system_phenotyp1.26132540
71MP0003786_premature_aging1.25227936
72MP0004808_abnormal_hematopoietic_stem1.22830656
73MP0003186_abnormal_redox_activity1.22692503
74MP0005379_endocrine/exocrine_gland_phen1.22586834
75MP0002751_abnormal_autonomic_nervous1.22358916
76MP0002254_reproductive_system_inflammat1.20889919
77MP0005409_darkened_coat_color1.18531749
78MP0000703_abnormal_thymus_morphology1.18116669
79MP0009672_abnormal_birth_weight1.17475532
80MP0009046_muscle_twitch1.14564135
81MP0004885_abnormal_endolymph1.11863248
82MP0002210_abnormal_sex_determination1.11376430
83MP0003119_abnormal_digestive_system1.04989589
84MP0002638_abnormal_pupillary_reflex1.04978929
85MP0008875_abnormal_xenobiotic_pharmacok1.04065158
86MP0001119_abnormal_female_reproductive1.02315645
87MP0004142_abnormal_muscle_tone1.02219653
88MP0003567_abnormal_fetal_cardiomyocyte1.01694168
89MP0002398_abnormal_bone_marrow1.00493055
90MP0004043_abnormal_pH_regulation0.99592843
91MP0001286_abnormal_eye_development0.99288978
92MP0000689_abnormal_spleen_morphology0.98427814
93MP0005671_abnormal_response_to0.98324641
94MP0003011_delayed_dark_adaptation0.98048951
95MP0002722_abnormal_immune_system0.96778793
96MP0005408_hypopigmentation0.94508262
97MP0005195_abnormal_posterior_eye0.94230287
98MP0005395_other_phenotype0.91186252
99MP0002019_abnormal_tumor_incidence0.90914979
100MP0004145_abnormal_muscle_electrophysio0.90772759
101MP0000653_abnormal_sex_gland0.90463477
102MP0001293_anophthalmia0.88577821
103MP0001145_abnormal_male_reproductive0.88533786
104MP0000647_abnormal_sebaceous_gland0.87976366
105MP0010678_abnormal_skin_adnexa0.87799698
106MP0002075_abnormal_coat/hair_pigmentati0.87699240
107MP0003698_abnormal_male_reproductive0.87390332
108MP0001905_abnormal_dopamine_level0.86980634
109MP0008995_early_reproductive_senescence0.86388832
110MP0001929_abnormal_gametogenesis0.86066558
111MP0000350_abnormal_cell_proliferation0.85399555
112MP0005391_vision/eye_phenotype0.84401653
113MP0001270_distended_abdomen0.82714276
114MP0009745_abnormal_behavioral_response0.82519311
115MP0001984_abnormal_olfaction0.82136253
116MP0004742_abnormal_vestibular_system0.81984154
117MP0005647_abnormal_sex_gland0.81864147
118MP0002234_abnormal_pharynx_morphology0.81624661
119MP0006035_abnormal_mitochondrial_morpho0.81010411
120MP0002928_abnormal_bile_duct0.80424871
121MP0000313_abnormal_cell_death0.80170748
122MP0001324_abnormal_eye_pigmentation0.79190995
123MP0002272_abnormal_nervous_system0.78973616
124MP0005451_abnormal_body_composition0.78537780
125MP0005084_abnormal_gallbladder_morpholo0.78073262
126MP0001730_embryonic_growth_arrest0.78000733
127MP0009333_abnormal_splenocyte_physiolog0.77005423
128MP0001873_stomach_inflammation0.77002375
129MP0002429_abnormal_blood_cell0.76831275
130MP0009703_decreased_birth_body0.76783719
131MP0000049_abnormal_middle_ear0.76462380
132MP0005410_abnormal_fertilization0.76417663
133MP0001186_pigmentation_phenotype0.76323973
134MP0002752_abnormal_somatic_nervous0.72525356
135MP0008789_abnormal_olfactory_epithelium0.72473424
136MP0003936_abnormal_reproductive_system0.71968078
137MP0000566_synostosis0.71541908
138MP0004215_abnormal_myocardial_fiber0.70754641
139MP0006276_abnormal_autonomic_nervous0.70538714
140MP0000467_abnormal_esophagus_morphology0.70413255
141MP0005636_abnormal_mineral_homeostasis0.69316852
142MP0002876_abnormal_thyroid_physiology0.68402648
143MP0001672_abnormal_embryogenesis/_devel0.63422366
144MP0005380_embryogenesis_phenotype0.63422366
145MP0001666_abnormal_nutrient_absorption0.62956684
146MP0003252_abnormal_bile_duct0.62789322
147MP0003122_maternal_imprinting0.62744623
148MP0003943_abnormal_hepatobiliary_system0.62193053
149MP0002080_prenatal_lethality0.61813625
150MP0003699_abnormal_female_reproductive0.61440127
151MP0000716_abnormal_immune_system0.60884598
152MP0001697_abnormal_embryo_size0.59834109
153MP0002138_abnormal_hepatobiliary_system0.58294333
154MP0005584_abnormal_enzyme/coenzyme_acti0.58236352
155MP0005332_abnormal_amino_acid0.56654703
156MP0004134_abnormal_chest_morphology0.54444892
157MP0003984_embryonic_growth_retardation0.54040664

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.59429770
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.37107893
3Abnormality of the heme biosynthetic pathway (HP:0010472)4.16053254
4Pancreatic cysts (HP:0001737)3.94240346
5Pancreatic fibrosis (HP:0100732)3.62018249
6Aplastic anemia (HP:0001915)3.53925483
7Type I transferrin isoform profile (HP:0003642)3.44412234
8True hermaphroditism (HP:0010459)3.35386641
9Hypoplasia of the thymus (HP:0000778)3.31938331
10Abnormality of midbrain morphology (HP:0002418)3.23577070
11Molar tooth sign on MRI (HP:0002419)3.23577070
12Birth length less than 3rd percentile (HP:0003561)3.18414811
13Premature graying of hair (HP:0002216)3.14795117
14Congenital stationary night blindness (HP:0007642)3.02727628
15Prostate neoplasm (HP:0100787)2.91077186
16Cellular immunodeficiency (HP:0005374)2.86091997
17Abnormal number of erythroid precursors (HP:0012131)2.85361390
18Microvesicular hepatic steatosis (HP:0001414)2.81587330
19Abnormality of chromosome stability (HP:0003220)2.80447400
20Colon cancer (HP:0003003)2.78751533
21Nephronophthisis (HP:0000090)2.78457054
22Abnormality of the renal collecting system (HP:0004742)2.76613718
23Hypoplasia of the capital femoral epiphysis (HP:0003090)2.75474886
24Abnormality of pyrimidine metabolism (HP:0004353)2.75336175
25Abolished electroretinogram (ERG) (HP:0000550)2.74283875
26Large for gestational age (HP:0001520)2.72267807
27Rough bone trabeculation (HP:0100670)2.69395516
283-Methylglutaconic aciduria (HP:0003535)2.67446086
29Patchy hypopigmentation of hair (HP:0011365)2.66910115
30Chronic hepatic failure (HP:0100626)2.65709431
31Abnormality of methionine metabolism (HP:0010901)2.65234230
32White forelock (HP:0002211)2.62222695
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.60346046
34Abnormal protein N-linked glycosylation (HP:0012347)2.60346046
35Abnormal protein glycosylation (HP:0012346)2.60346046
36Abnormal glycosylation (HP:0012345)2.60346046
37Abnormality of the prostate (HP:0008775)2.59680914
38Duplicated collecting system (HP:0000081)2.59156867
39Abnormality of the preputium (HP:0100587)2.58641042
40Pendular nystagmus (HP:0012043)2.54450722
41Attenuation of retinal blood vessels (HP:0007843)2.51929105
42Abnormality of cochlea (HP:0000375)2.51066751
43Abnormality of alanine metabolism (HP:0010916)2.51035332
44Hyperalaninemia (HP:0003348)2.51035332
45Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.51035332
46Abnormality of cells of the erythroid lineage (HP:0012130)2.50603403
47Reticulocytopenia (HP:0001896)2.49040623
48Abnormality of the renal cortex (HP:0011035)2.48948818
49Poikiloderma (HP:0001029)2.45918267
50Abnormality of the renal medulla (HP:0100957)2.44643402
51Bone marrow hypocellularity (HP:0005528)2.42678789
52Thyroid-stimulating hormone excess (HP:0002925)2.40987719
53T lymphocytopenia (HP:0005403)2.40794774
54Clubbing of toes (HP:0100760)2.40246327
55Type II lissencephaly (HP:0007260)2.39999211
56Absent epiphyses (HP:0010577)2.38772773
57Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.38772773
58Abnormality of DNA repair (HP:0003254)2.35167595
59Medulloblastoma (HP:0002885)2.34065300
60Pancytopenia (HP:0001876)2.33908696
61Myelodysplasia (HP:0002863)2.32464095
62Abnormal hair whorl (HP:0010721)2.31888302
63Abnormality of serum amino acid levels (HP:0003112)2.31763608
64B lymphocytopenia (HP:0010976)2.31420551
65Abnormality of B cell number (HP:0010975)2.31420551
66Meckel diverticulum (HP:0002245)2.31159422
67Gaze-evoked nystagmus (HP:0000640)2.29644340
68Hepatocellular necrosis (HP:0001404)2.27925792
69Agnosia (HP:0010524)2.26525018
70Abnormality of the labia minora (HP:0012880)2.25665491
71Abnormality of the ileum (HP:0001549)2.23632819
72Dry hair (HP:0011359)2.23533568
73Hypoplasia of the pons (HP:0012110)2.22669537
74Medial flaring of the eyebrow (HP:0010747)2.22448061
75Sclerocornea (HP:0000647)2.17635226
76Aplasia/Hypoplasia of the uvula (HP:0010293)2.17374866
77Cerebral hypomyelination (HP:0006808)2.16703057
78Volvulus (HP:0002580)2.15726146
79Cystic liver disease (HP:0006706)2.14716239
80Aplasia/Hypoplasia of the tongue (HP:0010295)2.12449834
81Oral leukoplakia (HP:0002745)2.12383278
82Intrahepatic cholestasis (HP:0001406)2.11194115
83Abnormality of T cell number (HP:0011839)2.09657705
84Methylmalonic acidemia (HP:0002912)2.09545219
85Furrowed tongue (HP:0000221)2.09416975
86Increased serum lactate (HP:0002151)2.08625161
87Severe combined immunodeficiency (HP:0004430)2.08499630
88Morphological abnormality of the inner ear (HP:0011390)2.08425958
89Increased CSF lactate (HP:0002490)2.08078888
90Congenital, generalized hypertrichosis (HP:0004540)2.07589112
91Absent thumb (HP:0009777)2.07190240
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.06613247
93Renal cortical cysts (HP:0000803)2.06063863
94Chorioretinal atrophy (HP:0000533)2.05283138
95Abnormal biliary tract physiology (HP:0012439)2.02638650
96Bile duct proliferation (HP:0001408)2.02638650
97Petechiae (HP:0000967)2.00943640
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.99589815
99Abnormality of sulfur amino acid metabolism (HP:0004339)1.99048378
100Abnormal auditory evoked potentials (HP:0006958)1.98625863
101Severe muscular hypotonia (HP:0006829)1.97505617
102Broad-based gait (HP:0002136)1.96209449
103Genetic anticipation (HP:0003743)1.95595343
104Hypergonadotropic hypogonadism (HP:0000815)1.95330350
105Hepatic necrosis (HP:0002605)1.94442930
106Anencephaly (HP:0002323)1.94306366
107Conjugated hyperbilirubinemia (HP:0002908)1.94158125
108Inability to walk (HP:0002540)1.94145831
109Hyperglycinuria (HP:0003108)1.94134237
110Abnormality of homocysteine metabolism (HP:0010919)1.93359696
111Homocystinuria (HP:0002156)1.93359696
112Aplasia/Hypoplasia of the tibia (HP:0005772)1.91199342
113Megaloblastic anemia (HP:0001889)1.90538977
114Decreased central vision (HP:0007663)1.89602210
115Optic nerve hypoplasia (HP:0000609)1.89501752
116Ectopic kidney (HP:0000086)1.89460483
117Prolonged bleeding time (HP:0003010)1.89405282
118Abnormality of the pons (HP:0007361)1.88837179
119Sloping forehead (HP:0000340)1.88116029
120Mitochondrial inheritance (HP:0001427)1.87257626
121Abnormal trabecular bone morphology (HP:0100671)1.87243711
122Bilateral microphthalmos (HP:0007633)1.87026412
123Lipid accumulation in hepatocytes (HP:0006561)1.86182991
124Duodenal stenosis (HP:0100867)1.86119201
125Small intestinal stenosis (HP:0012848)1.86119201
126Progressive inability to walk (HP:0002505)1.85490410
127Abnormal rod and cone electroretinograms (HP:0008323)1.84895974
128Acute necrotizing encephalopathy (HP:0006965)1.84389195
129Thrombocytosis (HP:0001894)1.84013445
130Protruding tongue (HP:0010808)1.82743810
131Pallor (HP:0000980)1.82550249
132Keratoconus (HP:0000563)1.81093123
133Increased corneal curvature (HP:0100692)1.81093123
134Small hand (HP:0200055)1.80399121
135Methylmalonic aciduria (HP:0012120)1.80013832
136Hyperbilirubinemia (HP:0002904)1.79642409
137Supernumerary spleens (HP:0009799)1.78800300
138Cerebellar dysplasia (HP:0007033)1.78272617
139Tubular atrophy (HP:0000092)1.78127376
140Combined immunodeficiency (HP:0005387)1.77123689
141Thoracic kyphosis (HP:0002942)1.77000435
142Short tibia (HP:0005736)1.76953826
143Abnormality of the carotid arteries (HP:0005344)1.75491612
144Fair hair (HP:0002286)1.75318756
145Abnormality of glycolysis (HP:0004366)1.75279827
146Increased serum pyruvate (HP:0003542)1.75279827
147Male pseudohermaphroditism (HP:0000037)1.74723456
148Aplasia/Hypoplasia of the thymus (HP:0010515)1.74689042
149Acute encephalopathy (HP:0006846)1.73716330
150Increased hepatocellular lipid droplets (HP:0006565)1.73421563
151Postaxial foot polydactyly (HP:0001830)1.73035923
152Dandy-Walker malformation (HP:0001305)1.72728875
153Lissencephaly (HP:0001339)1.72636724
154Irregular epiphyses (HP:0010582)1.72307450
155Abnormal mitochondria in muscle tissue (HP:0008316)1.71933293
156Patellar aplasia (HP:0006443)1.71687485
157Abnormality of the duodenum (HP:0002246)1.71478196
158Neutropenia (HP:0001875)1.71335449
159Congenital primary aphakia (HP:0007707)1.70894062
160Rhabdomyosarcoma (HP:0002859)1.70753116
161Hyperventilation (HP:0002883)1.70101428
162Abnormality of glycine metabolism (HP:0010895)1.69744520
163Abnormality of serine family amino acid metabolism (HP:0010894)1.69744520
164Preaxial hand polydactyly (HP:0001177)1.69235041
165Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68939089
166Aplasia/Hypoplasia of the patella (HP:0006498)1.68120003
167Congenital hepatic fibrosis (HP:0002612)1.67483923
168Absent rod-and cone-mediated responses on ERG (HP:0007688)1.67065960
169Genital tract atresia (HP:0001827)1.66722325
170Acute lymphatic leukemia (HP:0006721)1.66147723
171Hyperglycinemia (HP:0002154)1.65628371

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.33924530
2CDC73.50743136
3TSSK63.28930293
4CDK82.66077117
5STK162.58731422
6BUB12.44662797
7FLT32.37938902
8SIK32.31581604
9TXK2.16401903
10SRPK11.97379334
11CCNB11.92427188
12MAP2K71.89702575
13WEE11.82757603
14ATR1.82323121
15MKNK21.81157153
16VRK11.72849245
17LATS11.69056079
18MAP4K21.64999156
19NUAK11.64144775
20PRPF4B1.63979481
21CDK121.63837157
22TTK1.59452353
23BMPR1B1.56040945
24EIF2AK31.54846459
25TNIK1.53235304
26BRD41.52134080
27MKNK11.50429095
28MST41.50061691
29WNK41.49868319
30CASK1.48322841
31TAOK31.43609101
32CDK41.43507170
33SGK21.41708043
34TIE11.41064043
35EIF2AK11.35963160
36STK391.34332715
37OXSR11.29238979
38CDK71.24718091
39PNCK1.21631537
40PBK1.19547730
41ACVR1B1.19399141
42BRSK21.17054474
43TGFBR11.16983431
44DYRK31.16666177
45NME11.16556812
46AKT31.16489126
47VRK21.13742228
48PINK11.13265457
49ADRBK21.13106736
50BCKDK1.12549895
51BRAF1.10928950
52PLK11.10693394
53ERBB31.10574273
54PASK1.09402032
55TEC1.08078272
56YES11.04750545
57STK38L1.04748076
58NEK21.03191614
59CHEK20.97606484
60ATM0.97378529
61MAP4K10.94662098
62EEF2K0.92120210
63SGK4940.91283049
64SGK2230.91283049
65CHEK10.88508494
66PLK40.86649320
67MAP3K40.85602044
68INSRR0.85351170
69KIT0.84528321
70AURKB0.83452867
71TAF10.82175131
72TAOK20.81562127
73PLK30.80593365
74CDK30.79710144
75MAP3K100.77021076
76STK100.76590763
77TLK10.76267168
78RPS6KB20.75409827
79ZAK0.73265168
80NLK0.72611009
81MAPK70.72266690
82PIM10.69756552
83MAP3K140.69151754
84PLK20.66240621
85STK30.63178495
86DYRK20.62036353
87TRIM280.61977852
88SIK20.60697360
89ADRBK10.60631805
90NEK90.60521001
91CDK20.60041695
92CSNK1A1L0.58869256
93NEK60.58837886
94SGK30.58743433
95STK40.57905922
96PRKCE0.57550844
97CDK190.57505092
98MARK30.57126343
99ERBB40.56638293
100CSNK1G30.56483171
101BTK0.56128922
102PRKCG0.54896985
103RPS6KB10.54292697
104DYRK1A0.53410965
105ITK0.53218657
106GRK10.52673682
107CDK10.52466115
108CSNK2A20.50235419
109MAP3K120.49975990
110PRKCQ0.49050751
111CSNK1G10.48495079
112CSNK2A10.47631557
113AURKA0.47390218
114WNK30.46951685
115MAPK110.46679182
116MAPKAPK50.46649695
117CSNK1A10.45592519
118EIF2AK20.45302926
119RPS6KA50.45120624
120NME20.44971611
121PIM20.44747190
122MUSK0.44703262
123NEK10.44539923
124TRPM70.44218089
125FGFR20.44126560
126PIK3CA0.43322686
127PAK30.43065118
128TAOK10.42962393
129MAPK130.42767635
130BRSK10.41293876
131DAPK10.40671793
132CSNK1G20.39035907
133AKT20.38393349
134IKBKB0.34413177
135OBSCN0.33153359
136MAPKAPK30.32875683
137JAK30.30062335
138MAP2K60.28783237
139CSNK1D0.28236056
140CDK90.27213022
141MAP3K110.27151026
142PTK2B0.26712036
143CSNK1E0.26489094

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.97006227
2Mismatch repair_Homo sapiens_hsa034303.79848594
3Non-homologous end-joining_Homo sapiens_hsa034503.63286757
4One carbon pool by folate_Homo sapiens_hsa006703.35981719
5Homologous recombination_Homo sapiens_hsa034403.24240222
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.62903710
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.59079318
8Fanconi anemia pathway_Homo sapiens_hsa034602.57596001
9RNA polymerase_Homo sapiens_hsa030202.53928348
10Base excision repair_Homo sapiens_hsa034102.51688839
11Nucleotide excision repair_Homo sapiens_hsa034202.38362135
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.20814806
13Basal transcription factors_Homo sapiens_hsa030222.14972675
14Pyrimidine metabolism_Homo sapiens_hsa002402.14131343
15Spliceosome_Homo sapiens_hsa030402.11204589
16Phototransduction_Homo sapiens_hsa047441.91887914
17Ribosome_Homo sapiens_hsa030101.85381903
18Cell cycle_Homo sapiens_hsa041101.84800001
19RNA transport_Homo sapiens_hsa030131.76120823
20Proteasome_Homo sapiens_hsa030501.72721699
21RNA degradation_Homo sapiens_hsa030181.71260154
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.70795851
23Nitrogen metabolism_Homo sapiens_hsa009101.63303567
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.58885169
25Folate biosynthesis_Homo sapiens_hsa007901.57677404
26Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55537383
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.54354884
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.49378813
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.37202890
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.36264430
31Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33736343
32Selenocompound metabolism_Homo sapiens_hsa004501.33292938
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.30917694
34Primary immunodeficiency_Homo sapiens_hsa053401.28210300
35Peroxisome_Homo sapiens_hsa041461.26278512
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.25792621
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24042418
38Nicotine addiction_Homo sapiens_hsa050331.21043185
39Purine metabolism_Homo sapiens_hsa002301.19485009
40beta-Alanine metabolism_Homo sapiens_hsa004101.19090646
41Caffeine metabolism_Homo sapiens_hsa002321.17300138
42Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.16679549
43Taste transduction_Homo sapiens_hsa047421.16152318
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11519715
45Sulfur relay system_Homo sapiens_hsa041221.10688742
46Biosynthesis of amino acids_Homo sapiens_hsa012301.10441233
47Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08913211
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08405772
49Ether lipid metabolism_Homo sapiens_hsa005651.08238435
50Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07014236
51Vitamin B6 metabolism_Homo sapiens_hsa007501.04879336
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04848161
53mRNA surveillance pathway_Homo sapiens_hsa030151.00456318
54Protein export_Homo sapiens_hsa030600.99621827
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.97481659
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.95863435
57Pyruvate metabolism_Homo sapiens_hsa006200.95673487
58Steroid hormone biosynthesis_Homo sapiens_hsa001400.95521187
59Drug metabolism - other enzymes_Homo sapiens_hsa009830.94302902
60Glycerolipid metabolism_Homo sapiens_hsa005610.90910624
61Pentose phosphate pathway_Homo sapiens_hsa000300.85926341
62Histidine metabolism_Homo sapiens_hsa003400.84312084
63Olfactory transduction_Homo sapiens_hsa047400.79835601
64Fatty acid elongation_Homo sapiens_hsa000620.78178604
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72707589
66Metabolic pathways_Homo sapiens_hsa011000.72140506
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71687517
68Vitamin digestion and absorption_Homo sapiens_hsa049770.71579133
69Asthma_Homo sapiens_hsa053100.70695810
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69901319
71Lysine degradation_Homo sapiens_hsa003100.69487404
72Fatty acid metabolism_Homo sapiens_hsa012120.67634780
73Arginine and proline metabolism_Homo sapiens_hsa003300.67525111
74Carbon metabolism_Homo sapiens_hsa012000.66805202
75Steroid biosynthesis_Homo sapiens_hsa001000.66671720
76Sulfur metabolism_Homo sapiens_hsa009200.66641161
77Systemic lupus erythematosus_Homo sapiens_hsa053220.65738194
78Hematopoietic cell lineage_Homo sapiens_hsa046400.63502432
79Alzheimers disease_Homo sapiens_hsa050100.62717623
80Tyrosine metabolism_Homo sapiens_hsa003500.61699385
81Propanoate metabolism_Homo sapiens_hsa006400.61009908
82Chemical carcinogenesis_Homo sapiens_hsa052040.59794554
83Retinol metabolism_Homo sapiens_hsa008300.59701240
84N-Glycan biosynthesis_Homo sapiens_hsa005100.59675687
85Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58822603
86Butanoate metabolism_Homo sapiens_hsa006500.58203266
87Herpes simplex infection_Homo sapiens_hsa051680.56388006
88SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56129296
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53530504
90Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.52949967
91Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51689530
92Arginine biosynthesis_Homo sapiens_hsa002200.50944422
93p53 signaling pathway_Homo sapiens_hsa041150.50563749
94Tryptophan metabolism_Homo sapiens_hsa003800.50201296
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.49735884
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.48584084
97Fat digestion and absorption_Homo sapiens_hsa049750.48133098
98Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46678956
99Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46540003
100Parkinsons disease_Homo sapiens_hsa050120.45240655
101Fatty acid degradation_Homo sapiens_hsa000710.44993392
102Glutathione metabolism_Homo sapiens_hsa004800.44939538
103Oxidative phosphorylation_Homo sapiens_hsa001900.42407921
104Fatty acid biosynthesis_Homo sapiens_hsa000610.42083219
105Phenylalanine metabolism_Homo sapiens_hsa003600.41701591
106Fructose and mannose metabolism_Homo sapiens_hsa000510.41430182
107Epstein-Barr virus infection_Homo sapiens_hsa051690.41312014
108Cardiac muscle contraction_Homo sapiens_hsa042600.38394155
109Hedgehog signaling pathway_Homo sapiens_hsa043400.36542967
110Morphine addiction_Homo sapiens_hsa050320.35254969
111Serotonergic synapse_Homo sapiens_hsa047260.34801497
112Basal cell carcinoma_Homo sapiens_hsa052170.34629349
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.34143992
114Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32815401
115Huntingtons disease_Homo sapiens_hsa050160.31824133
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.28438074
117Viral carcinogenesis_Homo sapiens_hsa052030.27774048
118Type I diabetes mellitus_Homo sapiens_hsa049400.27753755
119Linoleic acid metabolism_Homo sapiens_hsa005910.27617520
120Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26866686
121Galactose metabolism_Homo sapiens_hsa000520.26763807
122Thyroid cancer_Homo sapiens_hsa052160.26440732
123Regulation of autophagy_Homo sapiens_hsa041400.26134357
124ABC transporters_Homo sapiens_hsa020100.24402336
125Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23643280
126Arachidonic acid metabolism_Homo sapiens_hsa005900.23467689
127alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.22794737
128Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20588750

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