METTL9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1melanin biosynthetic process (GO:0042438)6.37235811
2melanin metabolic process (GO:0006582)5.62946391
3secondary metabolite biosynthetic process (GO:0044550)5.42165488
4nucleobase catabolic process (GO:0046113)4.95993832
5Golgi transport vesicle coating (GO:0048200)4.86695599
6COPI coating of Golgi vesicle (GO:0048205)4.86695599
7exocrine pancreas development (GO:0031017)4.86505065
8maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.67759766
9positive regulation of mitochondrial fission (GO:0090141)4.63861136
10protein retention in ER lumen (GO:0006621)4.43037005
11presynaptic membrane assembly (GO:0097105)4.25723823
12SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17947997
13maternal placenta development (GO:0001893)4.15806966
14viral transcription (GO:0019083)4.15036780
15cerebral cortex radially oriented cell migration (GO:0021799)4.14796152
16neural tube formation (GO:0001841)4.14514769
17sequestering of actin monomers (GO:0042989)4.08623228
18protein targeting to ER (GO:0045047)4.08236110
19cotranslational protein targeting to membrane (GO:0006613)4.05522943
20translational termination (GO:0006415)4.03636904
21protein localization to endoplasmic reticulum (GO:0070972)3.92379667
22establishment of protein localization to endoplasmic reticulum (GO:0072599)3.88913865
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.83176321
24negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.80476684
25developmental pigmentation (GO:0048066)3.77568294
26neuron recognition (GO:0008038)3.77354581
27regulation of development, heterochronic (GO:0040034)3.69849585
28presynaptic membrane organization (GO:0097090)3.67670063
29dendrite morphogenesis (GO:0048813)3.67669050
30positive regulation of microtubule polymerization or depolymerization (GO:0031112)3.65187224
31negative regulation of RNA splicing (GO:0033119)3.63980716
32establishment of mitochondrion localization (GO:0051654)3.62265792
33embryonic foregut morphogenesis (GO:0048617)3.56775259
344-hydroxyproline metabolic process (GO:0019471)3.55087220
35melanosome organization (GO:0032438)3.54407580
36midgut development (GO:0007494)3.52546897
37establishment of melanosome localization (GO:0032401)3.52218728
38translational elongation (GO:0006414)3.49976625
39neuron cell-cell adhesion (GO:0007158)3.49896497
40pentose-phosphate shunt (GO:0006098)3.49692897
41peptidyl-arginine methylation (GO:0018216)3.45268169
42peptidyl-arginine N-methylation (GO:0035246)3.45268169
43postsynaptic membrane organization (GO:0001941)3.42833767
44axonal fasciculation (GO:0007413)3.39573908
45negative regulation of epidermis development (GO:0045683)3.39264474
46layer formation in cerebral cortex (GO:0021819)3.38961357
47mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.37572805
48positive regulation of microtubule polymerization (GO:0031116)3.36839124
49cell migration in hindbrain (GO:0021535)3.36640626
50type B pancreatic cell development (GO:0003323)3.29773056
51leukocyte migration involved in inflammatory response (GO:0002523)3.28776454
52establishment of pigment granule localization (GO:0051905)3.27645687
53G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.27621794
54pigment granule organization (GO:0048753)3.26741907
55NADPH regeneration (GO:0006740)3.26515815
56COPII vesicle coating (GO:0048208)3.25143759
57melanosome transport (GO:0032402)3.24784303
58neurofilament cytoskeleton organization (GO:0060052)3.23694853
59positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.21485465
60mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.21485465
61negative regulation of epidermal cell differentiation (GO:0045605)3.20142902
62dopaminergic neuron differentiation (GO:0071542)3.18716314
63cell wall macromolecule catabolic process (GO:0016998)3.18126364
64retinal ganglion cell axon guidance (GO:0031290)3.15736166
65nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12039644
66viral life cycle (GO:0019058)3.10139051
67positive regulation of nuclease activity (GO:0032075)3.10071848
68positive regulation of receptor biosynthetic process (GO:0010870)3.07458202
69negative regulation of mRNA processing (GO:0050686)3.06714342
70endocrine pancreas development (GO:0031018)3.05656870
71DNA unwinding involved in DNA replication (GO:0006268)3.04992264
72cerebral cortex cell migration (GO:0021795)3.04599302
73ribosomal small subunit assembly (GO:0000028)3.04385050
74cellular protein complex disassembly (GO:0043624)3.03457686
75limb bud formation (GO:0060174)3.01521540
76central nervous system projection neuron axonogenesis (GO:0021952)3.01082326
77protein K48-linked ubiquitination (GO:0070936)3.00679811
78pigment granule transport (GO:0051904)3.00341325
79cell proliferation in forebrain (GO:0021846)2.99897308
80translational initiation (GO:0006413)2.99147310
81activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.98555441
82nerve growth factor signaling pathway (GO:0038180)2.98459078
83lysine catabolic process (GO:0006554)2.97916740
84lysine metabolic process (GO:0006553)2.97916740
85regulation of cell-cell adhesion mediated by cadherin (GO:2000047)2.97752608
86olfactory bulb development (GO:0021772)2.96135232
87epithelial cell fate commitment (GO:0072148)2.92793620
88activated T cell proliferation (GO:0050798)2.92181849
89planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91491906
90protein targeting to membrane (GO:0006612)2.91108360
91neutrophil mediated immunity (GO:0002446)2.90403555
92axon extension involved in axon guidance (GO:0048846)2.85948569
93neuron projection extension involved in neuron projection guidance (GO:1902284)2.85948569
94glandular epithelial cell development (GO:0002068)2.85429784
95protein complex disassembly (GO:0043241)2.84598823
96pteridine-containing compound biosynthetic process (GO:0042559)2.84429856
97regulation of timing of cell differentiation (GO:0048505)2.83260929
98negative regulation of cell size (GO:0045792)2.82802127
99DNA deamination (GO:0045006)2.82098139
100melanosome localization (GO:0032400)2.81583368
101negative regulation of mRNA metabolic process (GO:1903312)2.80761214
102folic acid-containing compound biosynthetic process (GO:0009396)2.80528633
103negative regulation of oligodendrocyte differentiation (GO:0048715)2.77557527
104regulation of DNA methylation (GO:0044030)2.77027018
105astrocyte differentiation (GO:0048708)2.75633155
106regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75064026
107cell migration involved in heart development (GO:0060973)2.74940294
108regulation of nuclease activity (GO:0032069)2.74565038
109sequestering of metal ion (GO:0051238)2.73042875
110respiratory tube development (GO:0030323)2.71378261
111retinal rod cell development (GO:0046548)2.70647565
112regulation of microtubule polymerization (GO:0031113)2.70491865
113tricarboxylic acid metabolic process (GO:0072350)2.69941573
114paraxial mesoderm development (GO:0048339)2.68748166
115protein localization to synapse (GO:0035418)2.68169941
116regulation of mitochondrial fission (GO:0090140)2.67282641
117cardiac muscle cell proliferation (GO:0060038)2.66626183
118macromolecular complex disassembly (GO:0032984)2.66423304
119peptidyl-arginine omega-N-methylation (GO:0035247)2.66293327
120synapse assembly (GO:0007416)2.66185575
121positive regulation of neuroblast proliferation (GO:0002052)2.66014828
122auditory behavior (GO:0031223)2.65203323
123regulation of synapse structural plasticity (GO:0051823)2.64160708
124resolution of meiotic recombination intermediates (GO:0000712)2.62066971
125pigment granule localization (GO:0051875)2.61801585
126primitive streak formation (GO:0090009)2.61419208
127phenol-containing compound biosynthetic process (GO:0046189)2.61395521
128regulation of feeding behavior (GO:0060259)2.61010225
129negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.60578948
130peptidyl-arginine modification (GO:0018195)2.59763552
131head development (GO:0060322)2.59449667
132positive regulation of oligodendrocyte differentiation (GO:0048714)2.57895191
133axon regeneration (GO:0031103)2.57153189
134negative regulation of catenin import into nucleus (GO:0035414)2.56981838
135epithelial cell differentiation involved in prostate gland development (GO:0060742)2.56786062
136lung epithelium development (GO:0060428)2.55810102
137melanocyte differentiation (GO:0030318)2.55239203
138organelle transport along microtubule (GO:0072384)2.54931199
139glandular epithelial cell differentiation (GO:0002067)2.54594235
140negative chemotaxis (GO:0050919)2.54279655
141metanephric tubule development (GO:0072170)2.53444941
142metanephric nephron tubule development (GO:0072234)2.53444941
143regulation of heart morphogenesis (GO:2000826)2.53047065
144glyoxylate metabolic process (GO:0046487)2.53003488
145ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.52715184
146endoplasmic reticulum unfolded protein response (GO:0030968)2.52641183
147endocardial cushion morphogenesis (GO:0003203)2.51900278
148peptidyl-proline hydroxylation (GO:0019511)2.51119673
149axon extension (GO:0048675)2.50960761
150protein maturation by protein folding (GO:0022417)2.50831268
151signal peptide processing (GO:0006465)2.50659710
152dorsal/ventral axis specification (GO:0009950)2.50203238
153centriole replication (GO:0007099)2.48781084
154lens morphogenesis in camera-type eye (GO:0002089)2.48513131
155vesicle localization (GO:0051648)2.47882685
156chaperone-mediated protein transport (GO:0072321)2.47751134
157localization within membrane (GO:0051668)2.46773765
158spinal cord development (GO:0021510)2.46748186
159nucleoside salvage (GO:0043174)2.44641679
160positive regulation of synapse assembly (GO:0051965)2.44379032
161somite development (GO:0061053)2.43568803
162calcium-mediated signaling using intracellular calcium source (GO:0035584)2.43221249
163regulation of mesenchymal cell apoptotic process (GO:2001053)2.43205981
164central nervous system neuron axonogenesis (GO:0021955)2.43160634
165cell wall macromolecule metabolic process (GO:0044036)2.42984842
166retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.41302174
167positive regulation of gastrulation (GO:2000543)2.41170886
168proline biosynthetic process (GO:0006561)2.39912787
169heterochromatin organization (GO:0070828)2.39032771
170ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.38313702
171pyrimidine-containing compound salvage (GO:0008655)2.38176814
172pyrimidine nucleoside salvage (GO:0043097)2.38176814
173mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.37957406
174neurotransmitter-gated ion channel clustering (GO:0072578)2.37769023
175neuron projection extension (GO:1990138)2.37699821
176striated muscle cell proliferation (GO:0014855)2.37256647
177regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.37023859
178neuron fate determination (GO:0048664)2.36831699
179positive regulation of mast cell activation involved in immune response (GO:0033008)2.36763426
180positive regulation of mast cell degranulation (GO:0043306)2.36763426
181histone arginine methylation (GO:0034969)2.36459900
182pyrimidine nucleobase catabolic process (GO:0006208)2.36258836
183forebrain neuron differentiation (GO:0021879)2.36128836
184neuron migration (GO:0001764)2.35972348
185neuroepithelial cell differentiation (GO:0060563)2.35281294
186L-phenylalanine metabolic process (GO:0006558)2.34884884
187erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.34884884
188short-term memory (GO:0007614)2.34645120
189mammary gland epithelial cell differentiation (GO:0060644)2.34403569
190protein insertion into membrane (GO:0051205)2.34187858
191radial glial cell differentiation (GO:0060019)2.33439031
192calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.33269797
193positive regulation of male gonad development (GO:2000020)2.32919388
194microtubule severing (GO:0051013)2.32327851
195positive regulation of growth hormone secretion (GO:0060124)2.31474710
196regulation of growth hormone secretion (GO:0060123)2.30823932
197regulation of collateral sprouting (GO:0048670)2.30537172
198heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)2.30064197

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.99450523
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96821306
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.75318542
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.69498765
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.53814295
6FOXM1_23109430_ChIP-Seq_U2OS_Human3.49399048
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.28360189
8GBX2_23144817_ChIP-Seq_PC3_Human3.05154620
9E2F7_22180533_ChIP-Seq_HELA_Human3.00627869
10IGF1R_20145208_ChIP-Seq_DFB_Human2.99898438
11ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.78456141
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.74906850
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.71612334
14TAF15_26573619_Chip-Seq_HEK293_Human2.63269282
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58588396
16* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.56623781
17AR_21909140_ChIP-Seq_LNCAP_Human2.56227014
18WT1_19549856_ChIP-ChIP_CCG9911_Human2.54302044
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.51959475
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.46507194
21XRN2_22483619_ChIP-Seq_HELA_Human2.45699674
22POU3F2_20337985_ChIP-ChIP_501MEL_Human2.44375773
23CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.38752545
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.36822428
25CLOCK_20551151_ChIP-Seq_293T_Human2.31968624
26FUS_26573619_Chip-Seq_HEK293_Human2.17108003
27CNOT3_19339689_ChIP-ChIP_MESCs_Mouse2.13343386
28SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10854265
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.08009872
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.06836100
31SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.05333531
32TRIM28_19339689_ChIP-ChIP_MESCs_Mouse2.04618715
33PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.02982397
34TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.02450709
35CBX2_27304074_Chip-Seq_ESCs_Mouse2.02228865
36MYC_22102868_ChIP-Seq_BL_Human1.98537348
37ZNF274_21170338_ChIP-Seq_K562_Hela1.97026056
38* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.96258197
39OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.95219765
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.94189840
41P300_19829295_ChIP-Seq_ESCs_Human1.93371491
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.90842840
43EWS_26573619_Chip-Seq_HEK293_Human1.89661583
44RNF2_27304074_Chip-Seq_NSC_Mouse1.86792014
45NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.86075380
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.85130423
47* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.83731166
48RXR_22158963_ChIP-Seq_LIVER_Mouse1.82272759
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82106721
50NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79680322
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77221235
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.76907644
53GABP_17652178_ChIP-ChIP_JURKAT_Human1.74789955
54TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.74677307
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.73536373
56DCP1A_22483619_ChIP-Seq_HELA_Human1.72061852
57TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.70897299
58CTBP2_25329375_ChIP-Seq_LNCAP_Human1.68116952
59TTF2_22483619_ChIP-Seq_HELA_Human1.67214269
60* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66109299
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.65250244
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.64265463
63CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.64049629
64NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63381899
65MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.62254209
66PPARA_22158963_ChIP-Seq_LIVER_Mouse1.59158159
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57073049
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55560472
69JARID2_20064375_ChIP-Seq_MESCs_Mouse1.53659612
70POU5F1_16153702_ChIP-ChIP_HESCs_Human1.51955454
71ETS1_20019798_ChIP-Seq_JURKAT_Human1.50930664
72* GABP_19822575_ChIP-Seq_HepG2_Human1.50596523
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49140138
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.49086919
75RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47091236
76E2F4_17652178_ChIP-ChIP_JURKAT_Human1.46528821
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.45851259
78BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.45647121
79TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.41421538
80IRF1_19129219_ChIP-ChIP_H3396_Human1.40498017
81KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.39484610
82TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.38245627
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37362957
84* CHD1_26751641_Chip-Seq_LNCaP_Human1.36067699
85SMAD4_21799915_ChIP-Seq_A2780_Human1.35982337
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.35776633
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.35580326
88ESR1_15608294_ChIP-ChIP_MCF-7_Human1.35279195
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.34517235
90E2F1_21310950_ChIP-Seq_MCF-7_Human1.34497120
91TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34278736
92TAL1_26923725_Chip-Seq_HPCs_Mouse1.34268496
93* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.32054139
94ATF3_27146783_Chip-Seq_COLON_Human1.31687899
95HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31240161
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31177878
97JUN_21703547_ChIP-Seq_K562_Human1.30124108
98ELF1_17652178_ChIP-ChIP_JURKAT_Human1.30123384
99TBX3_20139965_ChIP-Seq_ESCs_Mouse1.29821785
100TBX3_20139965_ChIP-Seq_MESCs_Mouse1.29783079
101PIAS1_25552417_ChIP-Seq_VCAP_Human1.29685292
102CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29577125
103* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.27902985
104MYCN_18555785_ChIP-Seq_MESCs_Mouse1.27889675
105RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27700504
106LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27132392
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26894555
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26824480
109SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25700794
110SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.24213703
111STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.23846567
112* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23030413
113KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22751235
114PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.22467230
115SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.22109281
116TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20642998
117FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.20114051
118SOX2_16153702_ChIP-ChIP_HESCs_Human1.19537819
119SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.18191680
120AR_21572438_ChIP-Seq_LNCaP_Human1.16888629
121REST_21632747_ChIP-Seq_MESCs_Mouse1.16671166
122CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16347589
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.16147243
124ER_23166858_ChIP-Seq_MCF-7_Human1.16016370
125CIITA_25753668_ChIP-Seq_RAJI_Human1.15926921
126* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.15429893
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15053019
128* NANOG_21062744_ChIP-ChIP_HESCs_Human1.13559396
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11941093
130AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11901766
131DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10981791
132* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10945062
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10647682
134SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.10538445
135VDR_21846776_ChIP-Seq_THP-1_Human1.10377490
136* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.09989662
137FOXP1_21924763_ChIP-Seq_HESCs_Human1.09944059
138ZNF263_19887448_ChIP-Seq_K562_Human1.09303609
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09237785
140EGR1_19374776_ChIP-ChIP_THP-1_Human1.09128628
141SOX9_26525672_Chip-Seq_HEART_Mouse1.09092333
142CTCF_18555785_ChIP-Seq_MESCs_Mouse1.07930339
143SALL1_21062744_ChIP-ChIP_HESCs_Human1.07625330
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.07546442
145ZFP281_18757296_ChIP-ChIP_E14_Mouse1.07198886
146FLI1_21867929_ChIP-Seq_TH2_Mouse1.06940585
147RUNX2_22187159_ChIP-Seq_PCA_Human1.06178799
148ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05419440
149SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03179105
150FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03072284
151LXR_22158963_ChIP-Seq_LIVER_Mouse1.02559285
152LXR_22292898_ChIP-Seq_THP-1_Human1.02438818
153BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.02332667
154* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02150024
155* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02083211
156NR3C1_23031785_ChIP-Seq_PC12_Mouse1.02063054
157OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.01921171
158IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01464261
159CBP_20019798_ChIP-Seq_JUKART_Human1.01464261
160CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01168774
161KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.01022561
162AR_25329375_ChIP-Seq_VCAP_Human1.00786720
163CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.99954529
164SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99718264
165* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98683236
166SOX2_21211035_ChIP-Seq_LN229_Gbm0.98494659
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98424686
168NANOG_18555785_Chip-Seq_ESCs_Mouse0.98285249
169FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98216349
170REST_18959480_ChIP-ChIP_MESCs_Mouse0.98110485
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97156391
172* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.97001774
173CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96983704
174KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96962920
175KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96962920
176KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96962920
177NANOG_16153702_ChIP-ChIP_HESCs_Human0.96855057
178ELK3_25401928_ChIP-Seq_HUVEC_Human0.96781817
179VDR_22108803_ChIP-Seq_LS180_Human0.95252516
180ELK1_19687146_ChIP-ChIP_HELA_Human0.94985772
181TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93478290
182DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93222418
183POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.93128601
184TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92793487
185MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91690102
186PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.91290778
187TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88221409
188VDR_23849224_ChIP-Seq_CD4+_Human0.88179913
189EST1_17652178_ChIP-ChIP_JURKAT_Human0.87537365
190UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.86371305
191THAP11_20581084_ChIP-Seq_MESCs_Mouse0.86344424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005171_absent_coat_pigmentation4.77904257
2MP0000372_irregular_coat_pigmentation3.94035641
3MP0000569_abnormal_digit_pigmentation3.76391545
4MP0003136_yellow_coat_color3.67427125
5MP0010030_abnormal_orbit_morphology3.52951466
6MP0005408_hypopigmentation3.26032984
7MP0005075_abnormal_melanosome_morpholog3.25643354
8MP0002822_catalepsy2.80613261
9MP0009053_abnormal_anal_canal2.73828945
10MP0002095_abnormal_skin_pigmentation2.72871854
11MP0000537_abnormal_urethra_morphology2.70103367
12MP0006054_spinal_hemorrhage2.66974078
13MP0005220_abnormal_exocrine_pancreas2.66953923
14MP0000566_synostosis2.65653660
15MP0003123_paternal_imprinting2.54454432
16MP0000015_abnormal_ear_pigmentation2.52849398
17MP0003880_abnormal_central_pattern2.35726988
18MP0002139_abnormal_hepatobiliary_system2.24677099
19MP0003283_abnormal_digestive_organ2.20415169
20MP0000778_abnormal_nervous_system2.19043211
21MP0002282_abnormal_trachea_morphology2.12996355
22MP0009384_cardiac_valve_regurgitation2.08965592
23MP0000465_gastrointestinal_hemorrhage2.07566435
24MP0008438_abnormal_cutaneous_collagen2.07370206
25MP0001324_abnormal_eye_pigmentation2.06965151
26MP0005174_abnormal_tail_pigmentation2.02784961
27MP0010234_abnormal_vibrissa_follicle2.02713764
28MP0003122_maternal_imprinting1.96847469
29MP0005360_urolithiasis1.96461206
30MP0005365_abnormal_bile_salt1.96333201
31MP0002234_abnormal_pharynx_morphology1.89435860
32MP0002751_abnormal_autonomic_nervous1.89229637
33MP0004885_abnormal_endolymph1.88760313
34MP0002249_abnormal_larynx_morphology1.86276276
35MP0000462_abnormal_digestive_system1.84057765
36MP0003705_abnormal_hypodermis_morpholog1.84055748
37MP0001944_abnormal_pancreas_morphology1.82696078
38MP0004859_abnormal_synaptic_plasticity1.81159215
39MP0001666_abnormal_nutrient_absorption1.79259422
40MP0002837_dystrophic_cardiac_calcinosis1.75610701
41MP0000371_diluted_coat_color1.74670435
42MP0003119_abnormal_digestive_system1.73112824
43MP0003942_abnormal_urinary_system1.72557554
44MP0003252_abnormal_bile_duct1.65883980
45MP0005499_abnormal_olfactory_system1.61705096
46MP0005394_taste/olfaction_phenotype1.61705096
47MP0002932_abnormal_joint_morphology1.60930433
48MP0005084_abnormal_gallbladder_morpholo1.58583483
49MP0001529_abnormal_vocalization1.58537114
50MP0004142_abnormal_muscle_tone1.58439048
51MP0008789_abnormal_olfactory_epithelium1.54134248
52MP0006292_abnormal_olfactory_placode1.51228109
53MP0003115_abnormal_respiratory_system1.51127576
54MP0000049_abnormal_middle_ear1.51126015
55MP0005187_abnormal_penis_morphology1.48548850
56MP0004272_abnormal_basement_membrane1.46897411
57MP0009250_abnormal_appendicular_skeleto1.42229628
58MP0008877_abnormal_DNA_methylation1.39669934
59MP0006276_abnormal_autonomic_nervous1.39260577
60MP0002089_abnormal_postnatal_growth/wei1.38849400
61MP0000428_abnormal_craniofacial_morphol1.38786223
62MP0003315_abnormal_perineum_morphology1.36068144
63MP0002102_abnormal_ear_morphology1.34744754
64MP0002075_abnormal_coat/hair_pigmentati1.33726642
65MP0004957_abnormal_blastocyst_morpholog1.31944643
66MP0004043_abnormal_pH_regulation1.31246204
67MP0003567_abnormal_fetal_cardiomyocyte1.31218577
68MP0004381_abnormal_hair_follicle1.29038896
69MP0001984_abnormal_olfaction1.28291153
70MP0004270_analgesia1.28220634
71MP0000955_abnormal_spinal_cord1.25102489
72MP0002009_preneoplasia1.24298854
73MP0009379_abnormal_foot_pigmentation1.24133388
74MP0001186_pigmentation_phenotype1.24082148
75MP0004233_abnormal_muscle_weight1.23732352
76MP0002938_white_spotting1.23245609
77MP0002177_abnormal_outer_ear1.21436736
78MP0003195_calcinosis1.21105681
79MP0005248_abnormal_Harderian_gland1.19176388
80MP0003787_abnormal_imprinting1.19131025
81MP0009780_abnormal_chondrocyte_physiolo1.18942288
82MP0003868_abnormal_feces_composition1.18575658
83MP0005076_abnormal_cell_differentiation1.18575173
84MP0000163_abnormal_cartilage_morphology1.15531351
85MP0003635_abnormal_synaptic_transmissio1.15066303
86MP0009672_abnormal_birth_weight1.13598616
87MP0004811_abnormal_neuron_physiology1.13558695
88MP0003937_abnormal_limbs/digits/tail_de1.13217796
89MP0001188_hyperpigmentation1.12790385
90MP0000534_abnormal_ureter_morphology1.12669248
91MP0008260_abnormal_autophagy1.12280119
92MP0005253_abnormal_eye_physiology1.11478209
93MP0005085_abnormal_gallbladder_physiolo1.10707578
94MP0003121_genomic_imprinting1.09930734
95MP0000013_abnormal_adipose_tissue1.08402306
96MP0002896_abnormal_bone_mineralization1.07860403
97MP0001270_distended_abdomen1.07803877
98MP0005275_abnormal_skin_tensile1.07606524
99MP0003693_abnormal_embryo_hatching1.05555037
100MP0000003_abnormal_adipose_tissue1.03060440
101MP0005503_abnormal_tendon_morphology1.02741626
102MP0008961_abnormal_basal_metabolism1.02222030
103MP0002085_abnormal_embryonic_tissue1.01934776
104MP0001730_embryonic_growth_arrest1.01812062
105MP0002653_abnormal_ependyma_morphology1.01707290
106MP0003861_abnormal_nervous_system1.01397096
107MP0003011_delayed_dark_adaptation1.01304936
108MP0000678_abnormal_parathyroid_gland1.00427606
109MP0003385_abnormal_body_wall0.99693218
110MP0002909_abnormal_adrenal_gland0.98921469
111MP0004185_abnormal_adipocyte_glucose0.98905316
112MP0002877_abnormal_melanocyte_morpholog0.98768845
113MP0004197_abnormal_fetal_growth/weight/0.97500132
114MP0002063_abnormal_learning/memory/cond0.97255403
115MP0002084_abnormal_developmental_patter0.96709937
116MP0001486_abnormal_startle_reflex0.96195378
117MP0003935_abnormal_craniofacial_develop0.96166678
118MP0003300_gastrointestinal_ulcer0.95663192
119MP0002752_abnormal_somatic_nervous0.95552367
120MP0001697_abnormal_embryo_size0.95382632
121MP0002092_abnormal_eye_morphology0.95180180
122MP0002090_abnormal_vision0.94504346
123MP0002152_abnormal_brain_morphology0.93569645
124MP0003938_abnormal_ear_development0.92941729
125MP0003890_abnormal_embryonic-extraembry0.92759813
126MP0000613_abnormal_salivary_gland0.92655786
127MP0008932_abnormal_embryonic_tissue0.92269869
128MP0002693_abnormal_pancreas_physiology0.91738627
129MP0001293_anophthalmia0.91317792
130MP0009643_abnormal_urine_homeostasis0.91310460
131MP0005636_abnormal_mineral_homeostasis0.91267765
132MP0002111_abnormal_tail_morphology0.90045893
133MP0005391_vision/eye_phenotype0.89625980
134MP0002138_abnormal_hepatobiliary_system0.88684831
135MP0001348_abnormal_lacrimal_gland0.88435796
136MP0001849_ear_inflammation0.87754112
137MP0003221_abnormal_cardiomyocyte_apopto0.87362644
138MP0002882_abnormal_neuron_morphology0.87353954
139MP0000733_abnormal_muscle_development0.85224160
140MP0002184_abnormal_innervation0.85046102
141MP0002233_abnormal_nose_morphology0.84450924
142MP0002116_abnormal_craniofacial_bone0.84199334
143MP0000490_abnormal_crypts_of0.84030182
144MP0002638_abnormal_pupillary_reflex0.83478521
145MP0003755_abnormal_palate_morphology0.82730419
146MP0005666_abnormal_adipose_tissue0.82030251
147MP0002067_abnormal_sensory_capabilities0.81586354
148MP0005375_adipose_tissue_phenotype0.81479248
149MP0002928_abnormal_bile_duct0.80873906
150MP0000631_abnormal_neuroendocrine_gland0.80572563
151MP0004264_abnormal_extraembryonic_tissu0.80544772
152MP0002557_abnormal_social/conspecific_i0.79682470
153MP0005197_abnormal_uvea_morphology0.79257845
154MP0003724_increased_susceptibility_to0.78708720
155MP0005332_abnormal_amino_acid0.78453633
156MP0001286_abnormal_eye_development0.77192898
157MP0000026_abnormal_inner_ear0.77097953
158MP0002081_perinatal_lethality0.71918601
159MP0003718_maternal_effect0.71659042
160MP0005195_abnormal_posterior_eye0.70638028
161MP0005423_abnormal_somatic_nervous0.68832502
162MP0005409_darkened_coat_color0.67714350
163MP0002697_abnormal_eye_size0.65812163
164MP0002064_seizures0.65759734
165MP0004134_abnormal_chest_morphology0.65423306
166MP0002733_abnormal_thermal_nociception0.65190322
167MP0009278_abnormal_bone_marrow0.64795852
168MP0004742_abnormal_vestibular_system0.64545579
169MP0002734_abnormal_mechanical_nocicepti0.63771531
170MP0001177_atelectasis0.63016352
171MP0005551_abnormal_eye_electrophysiolog0.62284305

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the macula (HP:0008059)4.56225503
2Aplasia/Hypoplasia of the fovea (HP:0008060)4.23537645
3Hypoplasia of the fovea (HP:0007750)4.23537645
4Abnormality of the fovea (HP:0000493)4.19651915
5Aplasia/Hypoplasia affecting the retina (HP:0008061)4.16148300
6Hypoglycemic coma (HP:0001325)3.94027464
7Iris hypopigmentation (HP:0007730)3.88700525
8Ocular albinism (HP:0001107)3.82979724
9Generalized hypopigmentation (HP:0007513)3.82950902
10Ketoacidosis (HP:0001993)3.77770997
11Peripheral hypomyelination (HP:0007182)3.63213497
12Protrusio acetabuli (HP:0003179)3.53986512
13Papillary thyroid carcinoma (HP:0002895)3.43265889
14Decreased central vision (HP:0007663)3.37293849
15Blue irides (HP:0000635)3.33860423
16Heterochromia iridis (HP:0001100)3.28618924
17Multiple enchondromatosis (HP:0005701)3.01230047
18Ketosis (HP:0001946)2.99784977
19Abnormality of aromatic amino acid family metabolism (HP:0004338)2.98410877
20Lymphangioma (HP:0100764)2.98036751
21Congenital stationary night blindness (HP:0007642)2.94362828
22Limb dystonia (HP:0002451)2.94284956
23Amyotrophic lateral sclerosis (HP:0007354)2.92099345
24Hypopigmentation of the fundus (HP:0007894)2.80496274
25White forelock (HP:0002211)2.79275323
26Amblyopia (HP:0000646)2.78675027
27Thyroid carcinoma (HP:0002890)2.71710142
28Polyphagia (HP:0002591)2.71632127
29Short 4th metacarpal (HP:0010044)2.71206996
30Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.71206996
31Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.68629514
32Abnormality of the 4th metacarpal (HP:0010012)2.67777455
33Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.62870939
34Ulnar claw (HP:0001178)2.60455581
35Patchy hypopigmentation of hair (HP:0011365)2.59724110
36Synostosis involving the elbow (HP:0003938)2.57839083
37Humeroradial synostosis (HP:0003041)2.57839083
38Split foot (HP:0001839)2.55611189
39Cortical dysplasia (HP:0002539)2.55556390
40Failure to thrive in infancy (HP:0001531)2.54609014
41Abnormal hair whorl (HP:0010721)2.54268546
42Drooling (HP:0002307)2.53290591
43Late onset (HP:0003584)2.52792845
44Abnormality of endocrine pancreas physiology (HP:0012093)2.52629387
45Abnormality of the pancreatic islet cells (HP:0006476)2.52629387
46Gonadotropin excess (HP:0000837)2.52023461
47Reticulocytopenia (HP:0001896)2.45421000
48Aplastic anemia (HP:0001915)2.44904536
49Exostoses (HP:0100777)2.44556573
50Back pain (HP:0003418)2.44271601
51Coronal craniosynostosis (HP:0004440)2.44157328
52Megalencephaly (HP:0001355)2.42121673
53Visceral angiomatosis (HP:0100761)2.41895363
54Hypoglycemic seizures (HP:0002173)2.39052686
55Excessive salivation (HP:0003781)2.38501962
56Albinism (HP:0001022)2.37694665
57Congenital sensorineural hearing impairment (HP:0008527)2.36782885
58Delayed CNS myelination (HP:0002188)2.34670414
59Osteomalacia (HP:0002749)2.34198080
60Abnormal cartilage morphology (HP:0002763)2.33339046
61Abnormality of the labia minora (HP:0012880)2.31729187
62Retinal dysplasia (HP:0007973)2.29795444
63Renal duplication (HP:0000075)2.26817409
64Shallow orbits (HP:0000586)2.26404137
65Hemangiomatosis (HP:0007461)2.26260776
66Ankle contracture (HP:0006466)2.23766222
67Hyperinsulinemic hypoglycemia (HP:0000825)2.23265290
68Abnormality of fatty-acid metabolism (HP:0004359)2.21274499
69Bifid tongue (HP:0010297)2.20532051
70Abnormality of the pubic bones (HP:0003172)2.19132879
71Generalized aminoaciduria (HP:0002909)2.19105545
72Hip dysplasia (HP:0001385)2.18521442
73Severe visual impairment (HP:0001141)2.16379846
74Facial hemangioma (HP:0000329)2.12654903
75Cervical subluxation (HP:0003308)2.11797330
76Hyperglycinuria (HP:0003108)2.11444543
77Congenital glaucoma (HP:0001087)2.11372576
78Partial duplication of the phalanx of hand (HP:0009999)2.10868165
79Hepatic necrosis (HP:0002605)2.10812717
80Abnormality of glycine metabolism (HP:0010895)2.09412172
81Abnormality of serine family amino acid metabolism (HP:0010894)2.09412172
82Cerebellar dysplasia (HP:0007033)2.09400695
83Septo-optic dysplasia (HP:0100842)2.08081869
84Hepatoblastoma (HP:0002884)2.07773169
85Hypochromic microcytic anemia (HP:0004840)2.07709027
86Abnormality of the heme biosynthetic pathway (HP:0010472)2.07185919
87Freckling (HP:0001480)2.07142932
88Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06099831
89Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06099831
90Adenoma sebaceum (HP:0009720)2.05922984
91Angiofibromas (HP:0010615)2.05922984
92Abnormality of the intrinsic pathway (HP:0010989)2.04857233
93Cavernous hemangioma (HP:0001048)2.04123260
94Neonatal short-limb short stature (HP:0008921)2.03682249
95Deviation of the hallux (HP:0010051)2.01077750
96Agitation (HP:0000713)1.99382566
97Ankyloglossia (HP:0010296)1.98039046
98Medulloblastoma (HP:0002885)1.97638834
99Vitreoretinal degeneration (HP:0000655)1.97335758
100Abnormal pancreas size (HP:0012094)1.97050143
101Gout (HP:0001997)1.96535853
102Pheochromocytoma (HP:0002666)1.96368519
103Hallux valgus (HP:0001822)1.95274692
104Severe Myopia (HP:0011003)1.94845091
105Enlarged penis (HP:0000040)1.94785720
106Pachygyria (HP:0001302)1.94633815
107Colon cancer (HP:0003003)1.92891720
108Hyperammonemia (HP:0001987)1.92547189
109Morphological abnormality of the middle ear (HP:0008609)1.92522221
110Pancreatic islet-cell hyperplasia (HP:0004510)1.92414758
111Thin bony cortex (HP:0002753)1.90807178
112Broad metatarsal (HP:0001783)1.89841750
113Symptomatic seizures (HP:0011145)1.88030633
114Short tibia (HP:0005736)1.86196710
115Myoglobinuria (HP:0002913)1.85587487
116Myokymia (HP:0002411)1.85256193
117Atrophy/Degeneration involving motor neurons (HP:0007373)1.85025184
118Neonatal death (HP:0003811)1.84667430
119Progressive muscle weakness (HP:0003323)1.83714966
120Spastic diplegia (HP:0001264)1.83334349
121Optic nerve hypoplasia (HP:0000609)1.79979851
122Wide cranial sutures (HP:0010537)1.79923356
123Infantile muscular hypotonia (HP:0008947)1.78867759
124Conjunctival hamartoma (HP:0100780)1.78774770
125Subaortic stenosis (HP:0001682)1.78741925
126Abnormality of the left ventricular outflow tract (HP:0011103)1.78741925
127Degeneration of the lateral corticospinal tracts (HP:0002314)1.77423144
128Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.77423144
129Spinal cord lesions (HP:0100561)1.77225905
130Syringomyelia (HP:0003396)1.77225905
131Neoplasm of the thyroid gland (HP:0100031)1.76859375
132Dicarboxylic aciduria (HP:0003215)1.76090716
133Abnormality of dicarboxylic acid metabolism (HP:0010995)1.76090716
134Abnormality of oral frenula (HP:0000190)1.75739724
135Mitral valve prolapse (HP:0001634)1.75369501
136Insulin resistance (HP:0000855)1.75184834
137Sleep apnea (HP:0010535)1.73530268
138Abnormal auditory evoked potentials (HP:0006958)1.73255747
139Abnormality of the corticospinal tract (HP:0002492)1.73187603
140Hypobetalipoproteinemia (HP:0003563)1.72870213
141Hyperphosphaturia (HP:0003109)1.72453574
142Broad ribs (HP:0000885)1.71267931
143Neoplasm of the heart (HP:0100544)1.70964172
144Maternal diabetes (HP:0009800)1.70481807
145Lissencephaly (HP:0001339)1.70083036
146Specific learning disability (HP:0001328)1.69561209
147Long toe (HP:0010511)1.69506479
148Dysdiadochokinesis (HP:0002075)1.69344031
149Aortic aneurysm (HP:0004942)1.69139445
150Neoplasm of the oral cavity (HP:0100649)1.68723049
151Broad palm (HP:0001169)1.68614721
152True hermaphroditism (HP:0010459)1.68383818
153Pancreatic cysts (HP:0001737)1.68293668
154Abnormal eating behavior (HP:0100738)1.68153688
155Abnormality of the musculature of the pelvis (HP:0001469)1.67816786
156Abnormality of the hip-girdle musculature (HP:0001445)1.67816786
157Aortic dissection (HP:0002647)1.67708100
158Symphalangism affecting the phalanges of the hand (HP:0009773)1.67351060
159Supernumerary spleens (HP:0009799)1.67298162
160Bronchomalacia (HP:0002780)1.66735413
161Broad toe (HP:0001837)1.65191415
162Hyperactive renin-angiotensin system (HP:0000841)1.63398388
163Intellectual disability, moderate (HP:0002342)1.63394436
164Primary amenorrhea (HP:0000786)1.62939393
165Broad foot (HP:0001769)1.62565352
166Transitional cell carcinoma of the bladder (HP:0006740)1.62556679
167Microretrognathia (HP:0000308)1.61608483
168Ragged-red muscle fibers (HP:0003200)1.61556826
169Leiomyosarcoma (HP:0100243)1.61474346
170Uterine leiomyosarcoma (HP:0002891)1.61474346
171Hydroureter (HP:0000072)1.60834929
172Abnormality of the common coagulation pathway (HP:0010990)1.60578482
173Abnormality of cells of the erythroid lineage (HP:0012130)1.60267573
174Midline defect of the nose (HP:0004122)1.59754027
175Broad-based gait (HP:0002136)1.59520472
176Hyperglycinemia (HP:0002154)1.59429476
177Thoracolumbar scoliosis (HP:0002944)1.59226693
178Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.59004755
179Capillary hemangiomas (HP:0005306)1.58207637
180Abnormal hemoglobin (HP:0011902)1.57536128
181Deep venous thrombosis (HP:0002625)1.57474595
182Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.57366759
183Abnormality of salivation (HP:0100755)1.57280695
184Hypoplastic pelvis (HP:0008839)1.56922641
185Premature rupture of membranes (HP:0001788)1.56338502
186Acute encephalopathy (HP:0006846)1.56328337
187Poor suck (HP:0002033)1.56165634
188Erectile abnormalities (HP:0100639)1.56065974
189Bladder neoplasm (HP:0009725)1.55908158
190Bladder carcinoma (HP:0002862)1.55908158
191Striae distensae (HP:0001065)1.54841390
192Hyperglycemia (HP:0003074)1.54550010
193Intestinal polyp (HP:0005266)1.54116139
194Slender long bone (HP:0003100)1.53615683
195Intestinal polyposis (HP:0200008)1.53289653
196Severe short stature (HP:0003510)1.53096197

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.26706775
2BCKDK3.68872127
3MAP3K43.40841236
4PASK3.32087230
5PKN23.11928974
6ERN12.82878608
7MAP2K72.59289937
8CASK2.58003944
9TRIM282.53437204
10CSNK1G22.48637755
11DYRK32.48068379
12SCYL22.40747999
13ACVR1B2.31976857
14MAP3K102.20966224
15EIF2AK12.12804120
16PDGFRA2.07530495
17MAP2K42.07309546
18BUB12.04096585
19CSNK1A1L2.02063244
20LATS11.91050254
21KSR11.90475684
22EPHB21.89978289
23TGFBR11.77639573
24FLT31.76484779
25CDC71.74769707
26NTRK21.72299398
27MAP4K21.70371342
28LRRK21.65010182
29RPS6KA41.59260504
30PAK41.57971295
31NME21.57250261
32MOS1.54161469
33MAPK131.53800481
34NEK21.52680873
35EIF2AK31.49892806
36SIK11.48468990
37TESK21.47861153
38FRK1.47696071
39PTK61.44292225
40DYRK21.41610580
41DYRK1B1.40846555
42ILK1.40307245
43INSRR1.38332145
44MAP3K61.36867182
45WNK31.31902702
46LATS21.30786840
47ERBB21.29191854
48BMPR1B1.26157767
49BRD41.24898112
50TYRO31.24196132
51ARAF1.21901481
52WEE11.20195246
53FES1.20146132
54NEK11.18766115
55BRSK11.16855216
56GRK61.16639169
57EPHA41.06538065
58SIK21.05101846
59FGFR11.03947820
60PTK21.00904174
61YES11.00570602
62MINK10.99703869
63HIPK20.99310808
64TESK10.97230065
65KDR0.96964816
66BRSK20.94922191
67BMPR20.94808090
68TLK10.93004816
69EPHA30.92859825
70DDR20.92858934
71EEF2K0.92294886
72KSR20.91184511
73CDK40.90397704
74NTRK10.89120140
75LIMK10.88656897
76DYRK1A0.87775655
77MAP3K80.87709433
78STK240.86607787
79PLK20.86052143
80UHMK10.86011014
81SRPK10.84757176
82ABL20.83101897
83PINK10.83027149
84PAK20.80974917
85CDK80.80370599
86LMTK20.78537428
87AURKB0.77112879
88ERBB30.76093521
89FGR0.75721083
90MAP3K90.74774207
91MAP3K50.73567140
92TAOK10.73006436
93FGFR20.71563209
94CDK70.71556840
95CDK180.71456112
96CDK11A0.71235775
97PRKD30.70791867
98CDK150.67080220
99SGK4940.66912571
100SGK2230.66912571
101CDK50.64125647
102PAK30.62305321
103CDK30.61185383
104MELK0.61147556
105CSNK1D0.59969847
106MAP3K130.57680612
107PLK10.56751447
108NEK60.56539078
109MET0.56201068
110CLK10.56198234
111STK160.55663855
112MARK30.54778046
113MAP3K110.54540576
114PAK60.52497205
115TIE10.51990336
116SGK20.50998602
117AURKA0.50783635
118CSNK1G10.50558808
119MAPK110.48939496
120WNK40.48414956
121MAP2K30.48376390
122BCR0.48370781
123ICK0.47793332
124CDK60.47193258
125RET0.46851285
126MAP3K20.46497440
127PRKCZ0.46144385
128FER0.45934252
129EGFR0.44529158
130RAF10.44363378
131PRKACB0.44017854
132ADRBK10.43301435
133MAP2K20.42449521
134FYN0.42240500
135CDK90.42127395
136CAMKK10.41887931
137CDK190.41551853
138GSK3A0.40981203
139AKT20.40806530
140RPS6KA50.40782975
141ERBB40.39173545
142CSF1R0.38699922
143CAMK2A0.38439620
144KIT0.38387540
145LYN0.35558564
146FGFR40.35218514
147CSNK1G30.34571460
148PDGFRB0.34350652
149IRAK20.33928257
150CDK140.33423706
151CAMK40.33319571
152MARK10.32422262
153PRKCE0.32047118
154ROCK10.31703841
155STK38L0.31672320
156MAPK90.30098189
157RPS6KB10.30080612
158MAP2K10.28878262
159MKNK10.28798191
160NEK90.28731450
161IRAK10.28686461
162TTK0.27590327
163BTK0.27267058
164NLK0.27129892

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.12785917
2Protein export_Homo sapiens_hsa030603.12457572
3Ribosome_Homo sapiens_hsa030102.68523424
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.54657045
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.34302017
6Folate biosynthesis_Homo sapiens_hsa007902.28486652
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.28182501
8Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.24343173
9Fatty acid degradation_Homo sapiens_hsa000712.16091531
10Nicotine addiction_Homo sapiens_hsa050332.13838837
11Sulfur metabolism_Homo sapiens_hsa009202.13665399
12DNA replication_Homo sapiens_hsa030302.07168623
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.05938070
14Cyanoamino acid metabolism_Homo sapiens_hsa004602.04130559
15N-Glycan biosynthesis_Homo sapiens_hsa005101.96625086
16Butanoate metabolism_Homo sapiens_hsa006501.89132258
17Axon guidance_Homo sapiens_hsa043601.87838943
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.84655243
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84221656
20Propanoate metabolism_Homo sapiens_hsa006401.82596580
21Bladder cancer_Homo sapiens_hsa052191.64193072
22Spliceosome_Homo sapiens_hsa030401.62187546
23Fatty acid metabolism_Homo sapiens_hsa012121.58903836
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58746053
25Selenocompound metabolism_Homo sapiens_hsa004501.57002337
26Fat digestion and absorption_Homo sapiens_hsa049751.55820713
27Sulfur relay system_Homo sapiens_hsa041221.54549078
28Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.53642833
29Basal cell carcinoma_Homo sapiens_hsa052171.53418602
30GABAergic synapse_Homo sapiens_hsa047271.49383358
31Cell cycle_Homo sapiens_hsa041101.47914603
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.47568675
33Nitrogen metabolism_Homo sapiens_hsa009101.46012996
34Dopaminergic synapse_Homo sapiens_hsa047281.44493286
35Morphine addiction_Homo sapiens_hsa050321.43286057
36Carbon metabolism_Homo sapiens_hsa012001.42366060
37Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.42153759
38Shigellosis_Homo sapiens_hsa051311.37261597
39Cardiac muscle contraction_Homo sapiens_hsa042601.35619357
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.31807635
41Phototransduction_Homo sapiens_hsa047441.29568924
42Biosynthesis of amino acids_Homo sapiens_hsa012301.27258391
43RNA degradation_Homo sapiens_hsa030181.27057922
44Gap junction_Homo sapiens_hsa045401.25502097
45Fanconi anemia pathway_Homo sapiens_hsa034601.24664134
46Neurotrophin signaling pathway_Homo sapiens_hsa047221.22692744
47Steroid biosynthesis_Homo sapiens_hsa001001.20510552
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20052592
49Notch signaling pathway_Homo sapiens_hsa043301.19997125
50Melanoma_Homo sapiens_hsa052181.19282735
51Primary bile acid biosynthesis_Homo sapiens_hsa001201.18837822
52Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.18162954
53Regulation of autophagy_Homo sapiens_hsa041401.14721733
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.11669794
55Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.11022183
56Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.10518352
57Synaptic vesicle cycle_Homo sapiens_hsa047211.08550559
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08162574
59Tryptophan metabolism_Homo sapiens_hsa003801.07361971
60Cholinergic synapse_Homo sapiens_hsa047251.04157266
61Pyruvate metabolism_Homo sapiens_hsa006201.04110680
62Hedgehog signaling pathway_Homo sapiens_hsa043401.03553560
63Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01581868
64Ras signaling pathway_Homo sapiens_hsa040140.99047552
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98397876
66Basal transcription factors_Homo sapiens_hsa030220.98178103
67Protein digestion and absorption_Homo sapiens_hsa049740.96139207
68Rap1 signaling pathway_Homo sapiens_hsa040150.93999777
69Parkinsons disease_Homo sapiens_hsa050120.93565041
70Peroxisome_Homo sapiens_hsa041460.92908209
71Glutamatergic synapse_Homo sapiens_hsa047240.92723720
72Choline metabolism in cancer_Homo sapiens_hsa052310.91842430
73Glutathione metabolism_Homo sapiens_hsa004800.91571950
74Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91044237
75Caffeine metabolism_Homo sapiens_hsa002320.90206107
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89753902
77Long-term depression_Homo sapiens_hsa047300.89153691
78Drug metabolism - other enzymes_Homo sapiens_hsa009830.89084056
79Prolactin signaling pathway_Homo sapiens_hsa049170.87641818
80Pyrimidine metabolism_Homo sapiens_hsa002400.87599449
81Circadian entrainment_Homo sapiens_hsa047130.87329931
82Cocaine addiction_Homo sapiens_hsa050300.86054479
83Hippo signaling pathway_Homo sapiens_hsa043900.86021785
84Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83728355
85p53 signaling pathway_Homo sapiens_hsa041150.83056228
86Thyroid cancer_Homo sapiens_hsa052160.82849595
87Pentose phosphate pathway_Homo sapiens_hsa000300.82494300
88MAPK signaling pathway_Homo sapiens_hsa040100.81315330
89Phagosome_Homo sapiens_hsa041450.80674852
90ErbB signaling pathway_Homo sapiens_hsa040120.79865246
91Endocytosis_Homo sapiens_hsa041440.79676360
92PPAR signaling pathway_Homo sapiens_hsa033200.79431213
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.79294240
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.78093721
95Pathways in cancer_Homo sapiens_hsa052000.77406648
96Mismatch repair_Homo sapiens_hsa034300.76255414
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76236635
98Starch and sucrose metabolism_Homo sapiens_hsa005000.75551733
99Arginine and proline metabolism_Homo sapiens_hsa003300.75509425
100Proteoglycans in cancer_Homo sapiens_hsa052050.73273042
101Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.72808370
102Circadian rhythm_Homo sapiens_hsa047100.72164574
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.72067978
104Serotonergic synapse_Homo sapiens_hsa047260.71310785
105One carbon pool by folate_Homo sapiens_hsa006700.71143061
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70925248
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70615904
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70525356
109Fatty acid elongation_Homo sapiens_hsa000620.70461187
110Olfactory transduction_Homo sapiens_hsa047400.70022482
111Colorectal cancer_Homo sapiens_hsa052100.69996135
112beta-Alanine metabolism_Homo sapiens_hsa004100.69936530
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.69904087
114AMPK signaling pathway_Homo sapiens_hsa041520.68458675
115Chronic myeloid leukemia_Homo sapiens_hsa052200.68113267
116FoxO signaling pathway_Homo sapiens_hsa040680.67444589
117RNA transport_Homo sapiens_hsa030130.67053735
118Salmonella infection_Homo sapiens_hsa051320.66668464
119Nucleotide excision repair_Homo sapiens_hsa034200.66602289
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64883832
121Regulation of actin cytoskeleton_Homo sapiens_hsa048100.64693496
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.64401391
123Vibrio cholerae infection_Homo sapiens_hsa051100.64251691
124MicroRNAs in cancer_Homo sapiens_hsa052060.63660665
125Dorso-ventral axis formation_Homo sapiens_hsa043200.63623907
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.63117515
127Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62004430
128Pancreatic cancer_Homo sapiens_hsa052120.61866437
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.61794443
130Lysine degradation_Homo sapiens_hsa003100.61233492
131Glioma_Homo sapiens_hsa052140.60514294
132Small cell lung cancer_Homo sapiens_hsa052220.60488800
133mTOR signaling pathway_Homo sapiens_hsa041500.60135305
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.59695907
135Collecting duct acid secretion_Homo sapiens_hsa049660.59131765
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.58968045
137Taste transduction_Homo sapiens_hsa047420.55831349
138Long-term potentiation_Homo sapiens_hsa047200.55379280
139Insulin resistance_Homo sapiens_hsa049310.54507925
140Oocyte meiosis_Homo sapiens_hsa041140.52926462
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52674377
142Hepatitis B_Homo sapiens_hsa051610.52272068
143Systemic lupus erythematosus_Homo sapiens_hsa053220.52232334
144Base excision repair_Homo sapiens_hsa034100.50470483
145Wnt signaling pathway_Homo sapiens_hsa043100.50353856
146Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49415442
147Cysteine and methionine metabolism_Homo sapiens_hsa002700.49343295
148Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.48949358
149Endometrial cancer_Homo sapiens_hsa052130.48394012
150Non-small cell lung cancer_Homo sapiens_hsa052230.46810291
151Pancreatic secretion_Homo sapiens_hsa049720.46231879
152Alcoholism_Homo sapiens_hsa050340.45963472
153TGF-beta signaling pathway_Homo sapiens_hsa043500.45873823
154Huntingtons disease_Homo sapiens_hsa050160.45800257
155Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45613028
156Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44063857
157Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.43647720
158Adherens junction_Homo sapiens_hsa045200.43237902
159Insulin signaling pathway_Homo sapiens_hsa049100.39457419
160VEGF signaling pathway_Homo sapiens_hsa043700.39253479
161Renal cell carcinoma_Homo sapiens_hsa052110.37449114
162mRNA surveillance pathway_Homo sapiens_hsa030150.36726623
163Melanogenesis_Homo sapiens_hsa049160.35684010
164Glucagon signaling pathway_Homo sapiens_hsa049220.35556071
165Alzheimers disease_Homo sapiens_hsa050100.35478129
166Arginine biosynthesis_Homo sapiens_hsa002200.34988949
167Galactose metabolism_Homo sapiens_hsa000520.34740001
168Oxidative phosphorylation_Homo sapiens_hsa001900.34635111

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