MEX3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)5.51655606
2behavioral response to nicotine (GO:0035095)4.68728432
3nucleobase catabolic process (GO:0046113)4.17466683
4paraxial mesoderm development (GO:0048339)3.98128004
5pre-miRNA processing (GO:0031054)3.97393041
6cell proliferation in forebrain (GO:0021846)3.89291559
7planar cell polarity pathway involved in neural tube closure (GO:0090179)3.86752516
8presynaptic membrane assembly (GO:0097105)3.86435099
9protein localization to kinetochore (GO:0034501)3.83002599
10axonal fasciculation (GO:0007413)3.82283929
11postsynaptic membrane organization (GO:0001941)3.77705514
12neuron recognition (GO:0008038)3.76844108
13presynaptic membrane organization (GO:0097090)3.70222369
14viral transcription (GO:0019083)3.68140396
15regulation of telomere maintenance via telomerase (GO:0032210)3.60853051
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.60765953
17lateral sprouting from an epithelium (GO:0060601)3.59077708
18regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.58500870
19translational termination (GO:0006415)3.57820029
20nucleosome disassembly (GO:0006337)3.55237446
21protein-DNA complex disassembly (GO:0032986)3.55237446
22DNA unwinding involved in DNA replication (GO:0006268)3.50641008
23notochord development (GO:0030903)3.44245770
24retinal ganglion cell axon guidance (GO:0031290)3.40286610
25negative regulation of RNA splicing (GO:0033119)3.31372222
26forebrain neuron differentiation (GO:0021879)3.31245836
27axon extension involved in axon guidance (GO:0048846)3.29578380
28neuron projection extension involved in neuron projection guidance (GO:1902284)3.29578380
29head development (GO:0060322)3.29392277
30establishment of mitochondrion localization (GO:0051654)3.29058666
31negative regulation of epidermis development (GO:0045683)3.28490327
32sister chromatid segregation (GO:0000819)3.28416405
33cerebral cortex radially oriented cell migration (GO:0021799)3.25039608
34peptidyl-arginine omega-N-methylation (GO:0035247)3.23411786
35neuronal stem cell maintenance (GO:0097150)3.23033701
36body morphogenesis (GO:0010171)3.22631296
37axon extension (GO:0048675)3.21088583
38neuron cell-cell adhesion (GO:0007158)3.19835911
39proximal/distal pattern formation (GO:0009954)3.19184101
40negative regulation of mRNA processing (GO:0050686)3.16066288
41nuclear pore complex assembly (GO:0051292)3.15758929
42regulation of hippo signaling (GO:0035330)3.14884532
43histone H4-K8 acetylation (GO:0043982)3.13108020
44histone H4-K5 acetylation (GO:0043981)3.13108020
45mitotic sister chromatid segregation (GO:0000070)3.12444716
46dendritic spine morphogenesis (GO:0060997)3.09575384
47peptidyl-arginine methylation (GO:0018216)3.09160730
48peptidyl-arginine N-methylation (GO:0035246)3.09160730
49nuclear pore organization (GO:0006999)3.08586597
50heterochromatin organization (GO:0070828)3.07614896
51mRNA stabilization (GO:0048255)3.06440994
52RNA stabilization (GO:0043489)3.06440994
53somite development (GO:0061053)3.04881387
54pattern specification involved in kidney development (GO:0061004)3.04713120
55DNA replication-dependent nucleosome organization (GO:0034723)3.04695261
56DNA replication-dependent nucleosome assembly (GO:0006335)3.04695261
57mitochondrion transport along microtubule (GO:0047497)3.03059297
58establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.03059297
59regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.02435177
60protein localization to chromosome, centromeric region (GO:0071459)3.01429925
61histone arginine methylation (GO:0034969)3.01136415
62positive regulation of gastrulation (GO:2000543)3.01117502
63nonmotile primary cilium assembly (GO:0035058)3.00339333
64somite rostral/caudal axis specification (GO:0032525)2.99149200
65regulation of nuclear cell cycle DNA replication (GO:0033262)2.98516002
66embryonic body morphogenesis (GO:0010172)2.96179760
67substrate-independent telencephalic tangential migration (GO:0021826)2.95550795
68substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.95550795
69spinal cord association neuron differentiation (GO:0021527)2.90775007
70olfactory bulb development (GO:0021772)2.90602791
71DNA damage response, detection of DNA damage (GO:0042769)2.89602016
72regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87894972
73cell migration in hindbrain (GO:0021535)2.87767373
74camera-type eye morphogenesis (GO:0048593)2.87152844
75spinal cord development (GO:0021510)2.86869023
76primitive streak formation (GO:0090009)2.86448792
77limb bud formation (GO:0060174)2.86148538
78polarized epithelial cell differentiation (GO:0030859)2.85194233
79translational elongation (GO:0006414)2.81367586
80eyelid development in camera-type eye (GO:0061029)2.80143013
81bone trabecula formation (GO:0060346)2.79326733
82cochlea morphogenesis (GO:0090103)2.78540081
83regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.78091259
84regulation of mammary gland epithelial cell proliferation (GO:0033599)2.77823930
85establishment of monopolar cell polarity (GO:0061162)2.77654743
86establishment or maintenance of monopolar cell polarity (GO:0061339)2.77654743
87cellular protein complex disassembly (GO:0043624)2.77244225
88neuron fate determination (GO:0048664)2.76606004
89histone H4-K12 acetylation (GO:0043983)2.76287439
90hippo signaling (GO:0035329)2.76001355
91tongue development (GO:0043586)2.75617825
92chromatin assembly (GO:0031497)2.75495212
93ganglion development (GO:0061548)2.75403417
94hindlimb morphogenesis (GO:0035137)2.75058117
95embryonic hindlimb morphogenesis (GO:0035116)2.74760543
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.74441991
97cotranslational protein targeting to membrane (GO:0006613)2.74189869
98mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.73841838
99spliceosomal tri-snRNP complex assembly (GO:0000244)2.73222468
100glial cell proliferation (GO:0014009)2.73160742
101protein localization to synapse (GO:0035418)2.73064175
102regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.72705640
103regulation of gene silencing by RNA (GO:0060966)2.72230398
104regulation of posttranscriptional gene silencing (GO:0060147)2.72230398
105regulation of gene silencing by miRNA (GO:0060964)2.72230398
106auditory behavior (GO:0031223)2.72202139
107positive regulation of DNA-dependent DNA replication (GO:2000105)2.71381428
108kidney morphogenesis (GO:0060993)2.71263566
109SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.71079399
110protein complex disassembly (GO:0043241)2.69398953
111protein targeting to ER (GO:0045047)2.67385721
112positive regulation of synapse assembly (GO:0051965)2.67345913
113mRNA splice site selection (GO:0006376)2.66077166
114vocalization behavior (GO:0071625)2.65668671
115convergent extension (GO:0060026)2.65361566
116DNA duplex unwinding (GO:0032508)2.64943167
117Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.64336792
118synapse assembly (GO:0007416)2.62775296
119DNA geometric change (GO:0032392)2.62500619
120ribosomal small subunit biogenesis (GO:0042274)2.61969198
121regulation of telomere maintenance (GO:0032204)2.61953930
122viral life cycle (GO:0019058)2.61329301
123hindbrain development (GO:0030902)2.61275881
124dosage compensation (GO:0007549)2.60975175
125regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.60399309
126cell fate commitment involved in formation of primary germ layer (GO:0060795)2.60382771
127spindle assembly checkpoint (GO:0071173)2.59566366
128histone H4-K16 acetylation (GO:0043984)2.59450675
129transmission of nerve impulse (GO:0019226)2.59158337
130ribosomal small subunit assembly (GO:0000028)2.59130652
131gastrulation with mouth forming second (GO:0001702)2.59086199
132negative regulation of mRNA metabolic process (GO:1903312)2.58866359
133mechanosensory behavior (GO:0007638)2.58529191
134establishment of protein localization to endoplasmic reticulum (GO:0072599)2.57660962
135short-term memory (GO:0007614)2.57039530
136establishment of tissue polarity (GO:0007164)2.56796822
137establishment of planar polarity (GO:0001736)2.56796822
138intracellular estrogen receptor signaling pathway (GO:0030520)2.56576088
139limb development (GO:0060173)2.56482950
140appendage development (GO:0048736)2.56482950
141mitotic sister chromatid cohesion (GO:0007064)2.56083594
142neuron projection extension (GO:1990138)2.55916096
143maturation of SSU-rRNA (GO:0030490)2.55334854
144negative regulation of histone methylation (GO:0031061)2.54691439
145macromolecular complex disassembly (GO:0032984)2.54529289
146regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.53923350
147dendrite morphogenesis (GO:0048813)2.53553662
148positive regulation of neuroblast proliferation (GO:0002052)2.53169085
149negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.52871026
150mitotic chromosome condensation (GO:0007076)2.52849253
151negative regulation of epidermal cell differentiation (GO:0045605)2.52637451
152regulation of establishment of planar polarity (GO:0090175)2.52462560
153ATP-dependent chromatin remodeling (GO:0043044)2.51460065
154central nervous system projection neuron axonogenesis (GO:0021952)2.51363671
155negative regulation of axon guidance (GO:1902668)2.51324837
156mitotic spindle assembly checkpoint (GO:0007094)2.50851342
157calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.50284618
158negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.49999931
159spliceosomal complex assembly (GO:0000245)2.48759619
160negative regulation of chromosome segregation (GO:0051985)2.47552300
161otic vesicle formation (GO:0030916)2.47473201
162protein localization to chromosome (GO:0034502)2.46444912
163regulation of mRNA stability (GO:0043488)2.45809793
164segment specification (GO:0007379)2.45647509
165RNA localization (GO:0006403)2.44935809
166negative regulation of mitotic sister chromatid separation (GO:2000816)2.44808901
167negative regulation of mitotic sister chromatid segregation (GO:0033048)2.44808901
168negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.44808901
169negative regulation of sister chromatid segregation (GO:0033046)2.44808901
170mRNA splicing, via spliceosome (GO:0000398)2.44456082
171RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.44456082
172microtubule depolymerization (GO:0007019)2.44038329
173regulation of sister chromatid cohesion (GO:0007063)2.43921199
174RNA splicing, via transesterification reactions (GO:0000375)2.43867154
175protein localization to endoplasmic reticulum (GO:0070972)2.43755204
176intraciliary transport (GO:0042073)2.43748186
177neuron migration (GO:0001764)2.43628866
178epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.43453643
179negative regulation of translation, ncRNA-mediated (GO:0040033)2.43369376
180regulation of translation, ncRNA-mediated (GO:0045974)2.43369376
181negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.43369376
182cell differentiation in spinal cord (GO:0021515)2.42285394
183dendrite development (GO:0016358)2.40326310
184dopaminergic neuron differentiation (GO:0071542)2.37150348
185lens fiber cell development (GO:0070307)2.36961554
186adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.36928483

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.05830714
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.47878034
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.36911060
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.31379837
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.31379837
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.31379837
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.24181506
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.91103867
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86238291
10HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.85118287
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.66314188
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60404357
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46311215
14SOX2_18555785_ChIP-Seq_MESCs_Mouse2.44925529
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.41477367
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.32155977
17SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.30529107
18RNF2_27304074_Chip-Seq_ESCs_Mouse2.29520576
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.28937219
20STAT6_21828071_ChIP-Seq_BEAS2B_Human2.27441011
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24613118
22EZH2_18974828_ChIP-Seq_MESCs_Mouse2.23608667
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.23608667
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.18154758
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.13549173
26POU5F1_16153702_ChIP-ChIP_HESCs_Human2.13541394
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.11432165
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.10448163
29ZFP281_18757296_ChIP-ChIP_E14_Mouse2.09876836
30SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07174561
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.05930209
32RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.05072356
33REST_21632747_ChIP-Seq_MESCs_Mouse2.02729528
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02671239
35SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.02486300
36MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95074662
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.93683495
38NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.92870939
39HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.92632035
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.89989975
41* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.89655153
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.88165127
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.86236302
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.86168598
45SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.85616288
46MYC_19030024_ChIP-ChIP_MESCs_Mouse1.81835088
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80597634
48ERG_21242973_ChIP-ChIP_JURKAT_Human1.79697533
49SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.77295749
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75520384
51MYC_22102868_ChIP-Seq_BL_Human1.72314437
52SOX2_16153702_ChIP-ChIP_HESCs_Human1.69499416
53ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.66531437
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.65591798
55GATA1_26923725_Chip-Seq_HPCs_Mouse1.64531107
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.64474037
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.62420702
58NANOG_21062744_ChIP-ChIP_HESCs_Human1.61033407
59XRN2_22483619_ChIP-Seq_HELA_Human1.58652392
60SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.58038119
61NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.54845642
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54652736
63REST_18959480_ChIP-ChIP_MESCs_Mouse1.54179640
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.50050652
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.47809730
66NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.47610723
67RING1B_27294783_Chip-Seq_NPCs_Mouse1.47500017
68CIITA_25753668_ChIP-Seq_RAJI_Human1.46920413
69POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.46335858
70POU5F1_16518401_ChIP-PET_MESCs_Mouse1.45198893
71TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.43915456
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42183934
73SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41365286
74GBX2_23144817_ChIP-Seq_PC3_Human1.40421205
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.39782892
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.39423688
77TP53_20018659_ChIP-ChIP_R1E_Mouse1.37856294
78EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.37686699
79TTF2_22483619_ChIP-Seq_HELA_Human1.35910359
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33434958
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33434958
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.31814289
83MYC_18358816_ChIP-ChIP_MESCs_Mouse1.31385347
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30591380
85POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.30409440
86ZNF274_21170338_ChIP-Seq_K562_Hela1.30382191
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30346018
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.30332964
89ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30029291
90CTBP1_25329375_ChIP-Seq_LNCAP_Human1.29567973
91* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.25253284
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.24911995
93EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24538875
94NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24296655
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.23042058
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.22329863
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.21280874
98MTF2_20144788_ChIP-Seq_MESCs_Mouse1.19712766
99RNF2_27304074_Chip-Seq_NSC_Mouse1.19483594
100EZH2_22144423_ChIP-Seq_EOC_Human1.19248143
101NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.18672046
102NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18482820
103MYCN_18555785_ChIP-Seq_MESCs_Mouse1.17195491
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.16050066
105* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14572704
106RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14205724
107SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13734578
108ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.13261253
109PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12819086
110FUS_26573619_Chip-Seq_HEK293_Human1.12004580
111VDR_22108803_ChIP-Seq_LS180_Human1.10948509
112* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.09828819
113MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.09431335
114SOX2_18692474_ChIP-Seq_MESCs_Mouse1.09084995
115ISL1_27105846_Chip-Seq_CPCs_Mouse1.08716825
116WT1_19549856_ChIP-ChIP_CCG9911_Human1.08631124
117CTCF_27219007_Chip-Seq_Bcells_Human1.08282207
118GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08000967
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07197515
120EZH2_27304074_Chip-Seq_ESCs_Mouse1.06680336
121ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06597523
122STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.05216096
123PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05089480
124DROSHA_22980978_ChIP-Seq_HELA_Human1.04082308
125POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03414403
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.03151885
127BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02421840
128TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02343007
129HIF1A_21447827_ChIP-Seq_MCF-7_Human1.01757056
130SOX2_18692474_ChIP-Seq_MEFs_Mouse0.98587506
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98487797
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.98370418
133SMAD3_21741376_ChIP-Seq_ESCs_Human0.96644060
134ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96253604
135EWS_26573619_Chip-Seq_HEK293_Human0.96226608
136CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95859213
137TAF15_26573619_Chip-Seq_HEK293_Human0.94519901
138THAP11_20581084_ChIP-Seq_MESCs_Mouse0.93939901
139PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.93400152
140PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93275396
141SOX9_26525672_Chip-Seq_HEART_Mouse0.92598853
142EST1_17652178_ChIP-ChIP_JURKAT_Human0.92573078
143RING1B_27294783_Chip-Seq_ESCs_Mouse0.92072140
144IRF1_19129219_ChIP-ChIP_H3396_Human0.91630682
145AR_21909140_ChIP-Seq_LNCAP_Human0.90928970
146YY1_21170310_ChIP-Seq_MESCs_Mouse0.90902075
147P300_19829295_ChIP-Seq_ESCs_Human0.90693979
148OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89738232
149ESR1_15608294_ChIP-ChIP_MCF-7_Human0.88884883
150TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.88675451
151HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.88037992
152TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88018992
153FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.87769180
154P53_22127205_ChIP-Seq_FIBROBLAST_Human0.86744111
155* KDM2B_26808549_Chip-Seq_K562_Human0.85299343
156MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84728402
157MYC_18940864_ChIP-ChIP_HL60_Human0.84291762
158AR_21572438_ChIP-Seq_LNCaP_Human0.83198862
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82799076
160TOP2B_26459242_ChIP-Seq_MCF-7_Human0.82457318
161CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.81916192
162SOX3_22085726_ChIP-Seq_NPCs_Mouse0.81823067
163GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81287272
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.81214370

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology3.34859991
2MP0009379_abnormal_foot_pigmentation3.01229386
3MP0006292_abnormal_olfactory_placode2.93245262
4MP0003136_yellow_coat_color2.76318726
5MP0003122_maternal_imprinting2.75425850
6MP0003121_genomic_imprinting2.66570619
7MP0003890_abnormal_embryonic-extraembry2.63191560
8MP0000537_abnormal_urethra_morphology2.57859635
9MP0000049_abnormal_middle_ear2.42974321
10MP0005499_abnormal_olfactory_system2.34255591
11MP0005394_taste/olfaction_phenotype2.34255591
12MP0008789_abnormal_olfactory_epithelium2.32612820
13MP0002653_abnormal_ependyma_morphology2.25461270
14MP0009053_abnormal_anal_canal2.25407628
15MP0003123_paternal_imprinting2.24964378
16MP0003385_abnormal_body_wall2.18282732
17MP0001293_anophthalmia2.06193610
18MP0003119_abnormal_digestive_system2.02058004
19MP0002249_abnormal_larynx_morphology1.96650427
20MP0003942_abnormal_urinary_system1.94271132
21MP0003937_abnormal_limbs/digits/tail_de1.89551259
22MP0002938_white_spotting1.88271801
23MP0003315_abnormal_perineum_morphology1.87365332
24MP0004859_abnormal_synaptic_plasticity1.86380368
25MP0001188_hyperpigmentation1.86091046
26MP0003755_abnormal_palate_morphology1.81107400
27MP0004957_abnormal_blastocyst_morpholog1.79548361
28MP0003938_abnormal_ear_development1.78880593
29MP0003111_abnormal_nucleus_morphology1.77387498
30MP0003880_abnormal_central_pattern1.76743234
31MP0005248_abnormal_Harderian_gland1.75792637
32MP0002932_abnormal_joint_morphology1.75201181
33MP0006276_abnormal_autonomic_nervous1.75184399
34MP0005423_abnormal_somatic_nervous1.75122321
35MP0000955_abnormal_spinal_cord1.70191065
36MP0003935_abnormal_craniofacial_develop1.70119851
37MP0000778_abnormal_nervous_system1.69320661
38MP0000428_abnormal_craniofacial_morphol1.68758476
39MP0002233_abnormal_nose_morphology1.67509897
40MP0002085_abnormal_embryonic_tissue1.66145707
41MP0003077_abnormal_cell_cycle1.64540505
42MP0008057_abnormal_DNA_replication1.63752881
43MP0009250_abnormal_appendicular_skeleto1.63478647
44MP0003861_abnormal_nervous_system1.60235656
45MP0010094_abnormal_chromosome_stability1.59920872
46MP0002084_abnormal_developmental_patter1.59651287
47MP0002822_catalepsy1.58667008
48MP0002116_abnormal_craniofacial_bone1.56678474
49MP0001529_abnormal_vocalization1.55328493
50MP0003787_abnormal_imprinting1.53322753
51MP0003878_abnormal_ear_physiology1.51491474
52MP0005377_hearing/vestibular/ear_phenot1.51491474
53MP0002751_abnormal_autonomic_nervous1.51038005
54MP0001286_abnormal_eye_development1.49294561
55MP0002092_abnormal_eye_morphology1.48838995
56MP0001672_abnormal_embryogenesis/_devel1.48807839
57MP0005380_embryogenesis_phenotype1.48807839
58MP0004197_abnormal_fetal_growth/weight/1.45175333
59MP0008932_abnormal_embryonic_tissue1.42907156
60MP0000534_abnormal_ureter_morphology1.42764298
61MP0004885_abnormal_endolymph1.42555616
62MP0001485_abnormal_pinna_reflex1.40930116
63MP0000432_abnormal_head_morphology1.40626667
64MP0005257_abnormal_intraocular_pressure1.40208078
65MP0003635_abnormal_synaptic_transmissio1.39792028
66MP0003705_abnormal_hypodermis_morpholog1.38868000
67MP0000566_synostosis1.36976577
68MP0004142_abnormal_muscle_tone1.35483970
69MP0000350_abnormal_cell_proliferation1.34795285
70MP0002088_abnormal_embryonic_growth/wei1.33322747
71MP0002697_abnormal_eye_size1.32804310
72MP0002282_abnormal_trachea_morphology1.31424993
73MP0002557_abnormal_social/conspecific_i1.31386630
74MP0002114_abnormal_axial_skeleton1.31139400
75MP0003984_embryonic_growth_retardation1.30844118
76MP0004133_heterotaxia1.29578746
77MP0008007_abnormal_cellular_replicative1.29046727
78MP0000678_abnormal_parathyroid_gland1.28719271
79MP0001849_ear_inflammation1.26190388
80MP0002752_abnormal_somatic_nervous1.25775816
81MP0003693_abnormal_embryo_hatching1.24243309
82MP0002063_abnormal_learning/memory/cond1.23412114
83MP0002882_abnormal_neuron_morphology1.23186126
84MP0001984_abnormal_olfaction1.22644293
85MP0003115_abnormal_respiratory_system1.22513693
86MP0002111_abnormal_tail_morphology1.22072469
87MP0008877_abnormal_DNA_methylation1.21721953
88MP0002734_abnormal_mechanical_nocicepti1.20988514
89MP0005187_abnormal_penis_morphology1.20359717
90MP0002638_abnormal_pupillary_reflex1.19879661
91MP0000631_abnormal_neuroendocrine_gland1.19794828
92MP0001697_abnormal_embryo_size1.19677388
93MP0000516_abnormal_urinary_system1.19567068
94MP0005367_renal/urinary_system_phenotyp1.19567068
95MP0000762_abnormal_tongue_morphology1.19308018
96MP0002081_perinatal_lethality1.19005823
97MP0000026_abnormal_inner_ear1.18659011
98MP0001730_embryonic_growth_arrest1.18153476
99MP0010352_gastrointestinal_tract_polyps1.17162267
100MP0004270_analgesia1.17125638
101MP0002572_abnormal_emotion/affect_behav1.17027361
102MP0001299_abnormal_eye_distance/1.16615315
103MP0005076_abnormal_cell_differentiation1.15682936
104MP0004858_abnormal_nervous_system1.13785195
105MP0002272_abnormal_nervous_system1.13759557
106MP0003941_abnormal_skin_development1.13017530
107MP0003567_abnormal_fetal_cardiomyocyte1.12979342
108MP0009703_decreased_birth_body1.11431189
109MP0008058_abnormal_DNA_repair1.11045408
110MP0005623_abnormal_meninges_morphology1.07923856
111MP0004742_abnormal_vestibular_system1.07812855
112MP0002086_abnormal_extraembryonic_tissu1.07462225
113MP0005195_abnormal_posterior_eye1.06010149
114MP0004811_abnormal_neuron_physiology1.04867590
115MP0001486_abnormal_startle_reflex1.04482243
116MP0009745_abnormal_behavioral_response1.02846821
117MP0002109_abnormal_limb_morphology1.01076961
118MP0004264_abnormal_extraembryonic_tissu0.98991492
119MP0000733_abnormal_muscle_development0.98568442
120MP0002102_abnormal_ear_morphology0.98428689
121MP0002177_abnormal_outer_ear0.97890134
122MP0009672_abnormal_birth_weight0.97133367
123MP0001968_abnormal_touch/_nociception0.96802275
124MP0002736_abnormal_nociception_after0.96106036
125MP0000569_abnormal_digit_pigmentation0.95437838
126MP0005391_vision/eye_phenotype0.94354590
127MP0002080_prenatal_lethality0.94257546
128MP0002067_abnormal_sensory_capabilities0.94140757
129MP0002735_abnormal_chemical_nociception0.93078691
130MP0005508_abnormal_skeleton_morphology0.92666788
131MP0003011_delayed_dark_adaptation0.92229248
132MP0005645_abnormal_hypothalamus_physiol0.89005337
133MP0002925_abnormal_cardiovascular_devel0.88660784
134MP0002184_abnormal_innervation0.88579306
135MP0002064_seizures0.86740043
136MP0001440_abnormal_grooming_behavior0.86634517
137MP0002234_abnormal_pharynx_morphology0.84616926
138MP0001970_abnormal_pain_threshold0.84445198
139MP0000579_abnormal_nail_morphology0.84104510
140MP0003283_abnormal_digestive_organ0.82777899
141MP0002733_abnormal_thermal_nociception0.81598038
142MP0006072_abnormal_retinal_apoptosis0.81395228
143MP0002127_abnormal_cardiovascular_syste0.79478518
144MP0002152_abnormal_brain_morphology0.79421262
145MP0001963_abnormal_hearing_physiology0.77223204
146MP0001340_abnormal_eyelid_morphology0.75514984
147MP0005551_abnormal_eye_electrophysiolog0.74485963
148MP0001502_abnormal_circadian_rhythm0.74244331

Predicted human phenotypes

RankGene SetZ-score
1Hepatoblastoma (HP:0002884)3.96083319
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.96017916
3Short 4th metacarpal (HP:0010044)3.96017916
4Septo-optic dysplasia (HP:0100842)3.85307278
5Renal duplication (HP:0000075)3.65122504
6Bilateral microphthalmos (HP:0007633)3.60692229
7Abnormality of the 4th metacarpal (HP:0010012)3.15730437
8Rib fusion (HP:0000902)2.98540473
9Myokymia (HP:0002411)2.91137394
10Ependymoma (HP:0002888)2.88085280
11Reticulocytopenia (HP:0001896)2.80366841
12Medulloblastoma (HP:0002885)2.77472696
13Aplasia/Hypoplasia of the sternum (HP:0006714)2.69402376
14Increased nuchal translucency (HP:0010880)2.68230177
15Abnormality of the phalanges of the hallux (HP:0010057)2.61621794
16Nephroblastoma (Wilms tumor) (HP:0002667)2.61248112
17Abnormality of the astrocytes (HP:0100707)2.60721622
18Astrocytoma (HP:0009592)2.60721622
19Embryonal renal neoplasm (HP:0011794)2.51848661
20Atresia of the external auditory canal (HP:0000413)2.47919825
21Shawl scrotum (HP:0000049)2.47598375
22Neoplasm of striated muscle (HP:0009728)2.46363283
23Abnormal lung lobation (HP:0002101)2.45291501
24Supernumerary ribs (HP:0005815)2.42554671
25Absent septum pellucidum (HP:0001331)2.40589295
26Bifid tongue (HP:0010297)2.40177552
27Abnormal number of incisors (HP:0011064)2.39763889
28Abnormality of the intervertebral disk (HP:0005108)2.35627648
29Maternal diabetes (HP:0009800)2.35460152
30Patellar aplasia (HP:0006443)2.34635314
31Aplasia/Hypoplasia of the patella (HP:0006498)2.32968206
32Optic nerve hypoplasia (HP:0000609)2.23661780
33Nephronophthisis (HP:0000090)2.21997824
34Midline defect of the nose (HP:0004122)2.21819589
35Hyperacusis (HP:0010780)2.21777968
36Colon cancer (HP:0003003)2.21537177
37Rhabdomyosarcoma (HP:0002859)2.20820332
38Cortical dysplasia (HP:0002539)2.20628635
39Supernumerary bones of the axial skeleton (HP:0009144)2.19357250
40Abnormality of the distal phalanx of the thumb (HP:0009617)2.18971335
41Abnormality of the labia minora (HP:0012880)2.18911368
42Type II lissencephaly (HP:0007260)2.17196008
43Lissencephaly (HP:0001339)2.16503752
44Pachygyria (HP:0001302)2.15097610
45Abnormality of cells of the erythroid lineage (HP:0012130)2.14537112
46Shallow orbits (HP:0000586)2.14395302
47Supernumerary spleens (HP:0009799)2.12860633
48High anterior hairline (HP:0009890)2.12497929
49Pancreatic fibrosis (HP:0100732)2.12267473
50Cerebellar dysplasia (HP:0007033)2.11304562
51Chromosomal breakage induced by crosslinking agents (HP:0003221)2.10761813
52Oligodactyly (HP:0012165)2.10142708
53Drooling (HP:0002307)2.09365287
54Abnormality of midbrain morphology (HP:0002418)2.09082625
55Molar tooth sign on MRI (HP:0002419)2.09082625
56Anencephaly (HP:0002323)2.08909116
57Vaginal atresia (HP:0000148)2.08868087
58Gait imbalance (HP:0002141)2.08573267
59Glioma (HP:0009733)2.08393665
60Volvulus (HP:0002580)2.07930269
61Oligodactyly (hands) (HP:0001180)2.07512865
62Abnormality of the septum pellucidum (HP:0007375)2.06391773
63Short 5th finger (HP:0009237)2.04838137
64Genital tract atresia (HP:0001827)2.03984424
65Agitation (HP:0000713)2.03640630
66Ectopic kidney (HP:0000086)2.03465132
67True hermaphroditism (HP:0010459)2.03441005
68Broad thumb (HP:0011304)2.01585589
69Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.01109295
70Spina bifida occulta (HP:0003298)2.00088677
71Abnormality of the lower motor neuron (HP:0002366)1.99625045
72Aplasia/Hypoplasia of the brainstem (HP:0007362)1.99232323
73Hypoplasia of the brainstem (HP:0002365)1.99232323
74Renovascular hypertension (HP:0100817)1.98668368
75Preauricular skin tag (HP:0000384)1.98409945
76Skin tags (HP:0010609)1.98233574
77Abnormality of the diencephalon (HP:0010662)1.97034690
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96208314
79Partial duplication of the phalanx of hand (HP:0009999)1.95584881
80Sclerocornea (HP:0000647)1.94288027
81Selective tooth agenesis (HP:0001592)1.93823937
82Anophthalmia (HP:0000528)1.93343842
83Intestinal atresia (HP:0011100)1.91432037
84Progressive cerebellar ataxia (HP:0002073)1.90996259
85Elfin facies (HP:0004428)1.90389951
86Meckel diverticulum (HP:0002245)1.90200460
87Large earlobe (HP:0009748)1.88594293
88Abnormality of the pubic bones (HP:0003172)1.88054603
89Meningocele (HP:0002435)1.87814533
90Morphological abnormality of the middle ear (HP:0008609)1.87762044
91Neoplasm of the oral cavity (HP:0100649)1.85673767
92Medial flaring of the eyebrow (HP:0010747)1.85573877
93Cutaneous finger syndactyly (HP:0010554)1.84994447
94Abnormality of the ileum (HP:0001549)1.83557374
95Chromsome breakage (HP:0040012)1.83537886
96Pendular nystagmus (HP:0012043)1.83399315
97Pancreatic cysts (HP:0001737)1.82827247
98Excessive salivation (HP:0003781)1.82371700
99Facial hemangioma (HP:0000329)1.81801888
100Growth hormone deficiency (HP:0000824)1.81436201
101Overriding aorta (HP:0002623)1.81348283
102Gastrointestinal atresia (HP:0002589)1.80909232
103Aplasia/hypoplasia of the humerus (HP:0006507)1.80624030
104Aqueductal stenosis (HP:0002410)1.80409576
105Congenital diaphragmatic hernia (HP:0000776)1.80318518
106Proximal placement of thumb (HP:0009623)1.79769628
107Embryonal neoplasm (HP:0002898)1.79498996
108Vitreoretinal degeneration (HP:0000655)1.79325964
109Trigonocephaly (HP:0000243)1.79100681
110Turricephaly (HP:0000262)1.77419141
111Diastasis recti (HP:0001540)1.77052359
112Preaxial foot polydactyly (HP:0001841)1.76891486
113Short philtrum (HP:0000322)1.76034914
114Deviation of the thumb (HP:0009603)1.76008962
115Anterior segment dysgenesis (HP:0007700)1.75434593
116Broad alveolar ridges (HP:0000187)1.74936264
117Coronal craniosynostosis (HP:0004440)1.74816720
118Congenital primary aphakia (HP:0007707)1.74604265
119Hypochromic microcytic anemia (HP:0004840)1.74344774
120Micropenis (HP:0000054)1.74280622
121Hemivertebrae (HP:0002937)1.74112595
122Broad-based gait (HP:0002136)1.73896606
123Poor coordination (HP:0002370)1.73628422
124Renal hypoplasia (HP:0000089)1.73479914
125Broad toe (HP:0001837)1.72565363
126Optic nerve coloboma (HP:0000588)1.72381649
127Facial cleft (HP:0002006)1.72169900
128Abnormal pancreas size (HP:0012094)1.71973841
129Holoprosencephaly (HP:0001360)1.70727280
130Patellar dislocation (HP:0002999)1.70662096
131Labial hypoplasia (HP:0000066)1.70581932
132Renal dysplasia (HP:0000110)1.70284080
133Megalencephaly (HP:0001355)1.70116151
134Broad phalanges of the hand (HP:0009768)1.69894454
135Abnormality of the renal medulla (HP:0100957)1.69512756
136Cutaneous syndactyly (HP:0012725)1.69436029
137Abnormality of abdominal situs (HP:0011620)1.69191540
138Abdominal situs inversus (HP:0003363)1.69191540
139Limb dystonia (HP:0002451)1.68744392
140Down-sloping shoulders (HP:0200021)1.68214312
141Stenosis of the external auditory canal (HP:0000402)1.67897121
142Partial duplication of thumb phalanx (HP:0009944)1.67526913
143Polyphagia (HP:0002591)1.66849948
144Nephrogenic diabetes insipidus (HP:0009806)1.66778510
145Short humerus (HP:0005792)1.66757807
146Macrocytic anemia (HP:0001972)1.66668851
147Myelomeningocele (HP:0002475)1.66323344
148Hypospadias (HP:0000047)1.66246124
149Broad finger (HP:0001500)1.65938965
150Abnormal number of erythroid precursors (HP:0012131)1.65835355
151Abnormality of chromosome segregation (HP:0002916)1.64270948
152Vertebral fusion (HP:0002948)1.64270419
153Rectovaginal fistula (HP:0000143)1.64234065
154Rectal fistula (HP:0100590)1.64234065
155Sleep apnea (HP:0010535)1.64100831
156Neoplasm of the heart (HP:0100544)1.63849573
15711 pairs of ribs (HP:0000878)1.63763578
158Abnormality of the aortic arch (HP:0012303)1.62143892
159Uterine leiomyosarcoma (HP:0002891)1.62092485
160Leiomyosarcoma (HP:0100243)1.62092485
161Flat cornea (HP:0007720)1.61964108
162Aplasia/Hypoplasia of the uvula (HP:0010293)1.61899428
163Dandy-Walker malformation (HP:0001305)1.61833489
164Malignant neoplasm of the central nervous system (HP:0100836)1.61041882
165Hypoplastic female external genitalia (HP:0012815)1.60141986
166Esophageal atresia (HP:0002032)1.59769980
167Missing ribs (HP:0000921)1.59350002

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.18598790
2CASK4.35848334
3TNIK3.31670103
4MAP3K102.97471532
5CDC72.75186011
6MKNK12.74379155
7MARK12.72030911
8EPHB22.69132267
9SRPK12.61699679
10MKNK22.33493810
11DYRK22.01848349
12ERBB31.98466048
13TYRO31.91291622
14TTK1.85269439
15LATS11.85146488
16LATS21.78849181
17WNK31.75302188
18NEK21.73200582
19CDK71.72110481
20MAP3K41.69074706
21TLK11.62500901
22SIK21.62494087
23DYRK31.55958118
24ICK1.55846122
25MAP2K71.53961322
26BRD41.46995140
27EEF2K1.43039975
28CHEK21.39774974
29BMPR1B1.37140546
30PDGFRA1.35867561
31PLK11.32148572
32WNK41.31884231
33MINK11.31853603
34BUB11.31013592
35PAK41.27716551
36DDR21.23468602
37CDK191.23257884
38CAMK1D1.22207294
39NTRK31.22049217
40NTRK11.20987562
41CHEK11.17355765
42PRKCG1.16325869
43MAP3K91.14332188
44UHMK11.13718021
45KSR11.08517684
46MTOR1.08494395
47RPS6KB21.07853589
48STK161.07687383
49GRK61.06627599
50MAPK131.05903149
51TGFBR11.05401425
52ATR1.04902983
53PASK1.04600523
54EPHA41.04477663
55MAPK151.00118772
56ERBB20.97469677
57GRK50.95998104
58SGK2230.94469194
59SGK4940.94469194
60TAF10.94420474
61CDK20.93562368
62DYRK1B0.90031873
63FGFR10.87855711
64TRIB30.87422008
65AKT20.86182144
66MAP2K40.85445008
67PLK30.85281033
68CAMK40.85028592
69CSNK1A1L0.84920455
70STK110.84722373
71MARK20.84453404
72ATM0.83471476
73PKN20.82922863
74WEE10.80843351
75AURKA0.80574437
76AURKB0.80568129
77ADRBK20.80411968
78CDK10.80037169
79CSNK1G30.78903113
80CDK40.77722958
81ALK0.77384283
82EPHA30.77214179
83NTRK20.76136187
84EPHA20.76054511
85CSF1R0.74546938
86DMPK0.73576111
87PINK10.73560847
88YES10.69684137
89CDK50.67488730
90RPS6KA20.67197399
91PRKD30.66331593
92PAK20.66089384
93CSNK1G10.65805472
94CDK80.64954999
95CSNK1E0.64547938
96PRKCZ0.63093333
97PKN10.62763097
98ADRBK10.62192386
99MATK0.62006425
100CDK60.61875728
101PRKCI0.61857695
102SGK20.60861444
103INSRR0.60856481
104PRKCH0.60213637
105RIPK10.60073643
106STK100.58516839
107FGFR20.58288454
108BRSK10.58136724
109DYRK1A0.57951065
110NME10.57520499
111CDK140.56577631
112CDK30.56029437
113ILK0.54654881
114PNCK0.54438210
115ZAK0.53738207
116AKT30.53503916
117GRK10.53296159
118VRK20.53179965
119CAMK10.52166314
120MAPK90.51323553
121ACVR1B0.51088329
122GSK3B0.50726326
123AKT10.50345953
124PRKDC0.49319585
125PLK40.48175677
126MAPK140.48139879
127CAMKK10.47370642
128STK30.47287604
129WNK10.47208480
130RPS6KA60.46597475
131BCR0.46325967
132CSNK1G20.46296160
133LIMK10.45685911
134CDK11A0.45268510
135CDK180.45216008
136CDK150.44339108
137CSNK1D0.44023838
138CAMK1G0.43990674
139VRK10.43828846
140STK390.43822593
141MAPK70.43000525
142FGFR30.42809574
143SGK10.42625480
144MAPK80.42454990
145PTK60.42350696
146NUAK10.42149754
147TGFBR20.41953464
148PAK30.41346064

Predicted pathways (KEGG)

RankGene SetZ-score
1Spliceosome_Homo sapiens_hsa030403.26511781
2Basal cell carcinoma_Homo sapiens_hsa052173.24833487
3Nicotine addiction_Homo sapiens_hsa050333.00315479
4mRNA surveillance pathway_Homo sapiens_hsa030152.81871806
5RNA transport_Homo sapiens_hsa030132.62126334
6Cell cycle_Homo sapiens_hsa041102.56816116
7Hedgehog signaling pathway_Homo sapiens_hsa043402.54469123
8DNA replication_Homo sapiens_hsa030302.50487951
9Mismatch repair_Homo sapiens_hsa034302.42319091
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.39266904
11Hippo signaling pathway_Homo sapiens_hsa043902.29734811
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.27540872
13Cardiac muscle contraction_Homo sapiens_hsa042602.26610015
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.09015838
15Ribosome_Homo sapiens_hsa030102.08611811
16Notch signaling pathway_Homo sapiens_hsa043302.05641767
17Oxidative phosphorylation_Homo sapiens_hsa001902.02903188
18Base excision repair_Homo sapiens_hsa034102.01249439
19Parkinsons disease_Homo sapiens_hsa050121.96061515
20Fanconi anemia pathway_Homo sapiens_hsa034601.92419442
21Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.91418665
22MicroRNAs in cancer_Homo sapiens_hsa052061.88231738
23Axon guidance_Homo sapiens_hsa043601.79878204
24Wnt signaling pathway_Homo sapiens_hsa043101.79025524
25Colorectal cancer_Homo sapiens_hsa052101.74248743
26Homologous recombination_Homo sapiens_hsa034401.67614023
27Cocaine addiction_Homo sapiens_hsa050301.66234605
28Huntingtons disease_Homo sapiens_hsa050161.60115289
29Glutamatergic synapse_Homo sapiens_hsa047241.58624750
30Phototransduction_Homo sapiens_hsa047441.56082189
31Nucleotide excision repair_Homo sapiens_hsa034201.53193254
32One carbon pool by folate_Homo sapiens_hsa006701.53119399
33Morphine addiction_Homo sapiens_hsa050321.51468909
34Endometrial cancer_Homo sapiens_hsa052131.51001138
35RNA degradation_Homo sapiens_hsa030181.50256937
36Steroid biosynthesis_Homo sapiens_hsa001001.45340090
37Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42909177
38Adherens junction_Homo sapiens_hsa045201.41299656
39TGF-beta signaling pathway_Homo sapiens_hsa043501.40230539
40Alzheimers disease_Homo sapiens_hsa050101.36262876
41GABAergic synapse_Homo sapiens_hsa047271.35680249
42Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.35309940
43Dopaminergic synapse_Homo sapiens_hsa047281.34140607
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.32253988
45Cholinergic synapse_Homo sapiens_hsa047251.31418515
46Circadian entrainment_Homo sapiens_hsa047131.30276530
47RNA polymerase_Homo sapiens_hsa030201.27447973
48Basal transcription factors_Homo sapiens_hsa030221.24109188
49Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.23801941
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22908360
51Thyroid cancer_Homo sapiens_hsa052161.21237402
52Chronic myeloid leukemia_Homo sapiens_hsa052201.20909963
53Pathways in cancer_Homo sapiens_hsa052001.20125171
54HTLV-I infection_Homo sapiens_hsa051661.19513807
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17786909
56p53 signaling pathway_Homo sapiens_hsa041151.16446356
57Oocyte meiosis_Homo sapiens_hsa041141.13322234
58mTOR signaling pathway_Homo sapiens_hsa041501.11833228
59Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11462985
60Proteoglycans in cancer_Homo sapiens_hsa052051.10250219
61Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.08719070
62Bladder cancer_Homo sapiens_hsa052191.07303450
63Tight junction_Homo sapiens_hsa045301.05343252
64Insulin secretion_Homo sapiens_hsa049111.04951832
65Lysine degradation_Homo sapiens_hsa003101.03600414
66Small cell lung cancer_Homo sapiens_hsa052221.03462628
67Melanogenesis_Homo sapiens_hsa049161.01717826
68Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.01264172
69Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.99957378
70Viral myocarditis_Homo sapiens_hsa054160.99765610
71Taste transduction_Homo sapiens_hsa047420.98579107
72Serotonergic synapse_Homo sapiens_hsa047260.97721517
73Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97433335
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94972328
75Non-small cell lung cancer_Homo sapiens_hsa052230.93158259
76Protein export_Homo sapiens_hsa030600.90477691
77Viral carcinogenesis_Homo sapiens_hsa052030.89310029
78Non-homologous end-joining_Homo sapiens_hsa034500.87195357
79Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85932316
80Melanoma_Homo sapiens_hsa052180.85426518
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.84730875
82Alcoholism_Homo sapiens_hsa050340.83811878
83Systemic lupus erythematosus_Homo sapiens_hsa053220.83458594
84Prostate cancer_Homo sapiens_hsa052150.82892155
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81578213
86Central carbon metabolism in cancer_Homo sapiens_hsa052300.79039485
87Amphetamine addiction_Homo sapiens_hsa050310.78608159
88Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78419953
89Rap1 signaling pathway_Homo sapiens_hsa040150.75850544
90ErbB signaling pathway_Homo sapiens_hsa040120.75341091
91Pyrimidine metabolism_Homo sapiens_hsa002400.75220868
92Renal cell carcinoma_Homo sapiens_hsa052110.73934014
93Pancreatic cancer_Homo sapiens_hsa052120.73897044
94Neurotrophin signaling pathway_Homo sapiens_hsa047220.73088586
95Glioma_Homo sapiens_hsa052140.72588247
96Synaptic vesicle cycle_Homo sapiens_hsa047210.71488068
97Olfactory transduction_Homo sapiens_hsa047400.70305650
98Focal adhesion_Homo sapiens_hsa045100.70037981
99PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69674942
100cAMP signaling pathway_Homo sapiens_hsa040240.69215079
101Sulfur relay system_Homo sapiens_hsa041220.69157662
102Herpes simplex infection_Homo sapiens_hsa051680.67941078
103Epstein-Barr virus infection_Homo sapiens_hsa051690.67104071
104Oxytocin signaling pathway_Homo sapiens_hsa049210.66821713
105Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66528498
106alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65444078
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65118763
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62790858
109Acute myeloid leukemia_Homo sapiens_hsa052210.60003117
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59944692
111Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59836655
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59416833
113Gap junction_Homo sapiens_hsa045400.59311864
114Linoleic acid metabolism_Homo sapiens_hsa005910.57481036
115FoxO signaling pathway_Homo sapiens_hsa040680.49821970
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49054549
117ECM-receptor interaction_Homo sapiens_hsa045120.48287947
118Ether lipid metabolism_Homo sapiens_hsa005650.47397675
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.47144092
120AMPK signaling pathway_Homo sapiens_hsa041520.46965695
121VEGF signaling pathway_Homo sapiens_hsa043700.46499744
122Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45840160
123Dorso-ventral axis formation_Homo sapiens_hsa043200.45610876
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45134293
125Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43575762
126Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43159709
127Maturity onset diabetes of the young_Homo sapiens_hsa049500.41835030
128Selenocompound metabolism_Homo sapiens_hsa004500.40339520
129MAPK signaling pathway_Homo sapiens_hsa040100.40187773
130Butanoate metabolism_Homo sapiens_hsa006500.39456904
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38651859
132Thyroid hormone synthesis_Homo sapiens_hsa049180.38468105
133Ovarian steroidogenesis_Homo sapiens_hsa049130.38368105
134Hepatitis B_Homo sapiens_hsa051610.37734505
135Ras signaling pathway_Homo sapiens_hsa040140.37430089
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.37179901
137Choline metabolism in cancer_Homo sapiens_hsa052310.36424093
138Gastric acid secretion_Homo sapiens_hsa049710.35518625
139Prolactin signaling pathway_Homo sapiens_hsa049170.34468579
140Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34325695
141Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34251630
142Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32966886
143Apoptosis_Homo sapiens_hsa042100.32410484
144Phospholipase D signaling pathway_Homo sapiens_hsa040720.31771349
145Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31592010
146Estrogen signaling pathway_Homo sapiens_hsa049150.28212704
147Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27238236
148Leukocyte transendothelial migration_Homo sapiens_hsa046700.26597404
149N-Glycan biosynthesis_Homo sapiens_hsa005100.24716202
150Long-term depression_Homo sapiens_hsa047300.24532465
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.24517081
152Insulin signaling pathway_Homo sapiens_hsa049100.23630991
153Dilated cardiomyopathy_Homo sapiens_hsa054140.23485997

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