MEX3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an RNA-binding phosphoprotein that is part of the MEX3 (muscle excess 3) family of translational regulators. The encoded protein contains N-terminal nuclear export and nuclear localization signals and is exported from the cytoplasm to the nucleus. The protein binds to RNA via two KH domains and also colocalizes with MEX3A, Dcp1A decapping factor and Argonaute proteins within P (processing) bodies. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1acrosome reaction (GO:0007340)6.40021205
2sperm motility (GO:0030317)5.90276682
3spermatid nucleus differentiation (GO:0007289)5.86455184
4chromosome condensation (GO:0030261)5.22930406
5DNA packaging (GO:0006323)4.94797222
6spermatid development (GO:0007286)4.75754750
7axonal fasciculation (GO:0007413)4.64072929
8fusion of sperm to egg plasma membrane (GO:0007342)4.62114928
9response to pheromone (GO:0019236)4.60972393
10single strand break repair (GO:0000012)4.56749865
11cell migration in hindbrain (GO:0021535)4.54573492
12negative regulation of inclusion body assembly (GO:0090084)4.51325664
13layer formation in cerebral cortex (GO:0021819)4.49407064
14neuron recognition (GO:0008038)4.48539676
15microtubule severing (GO:0051013)4.41451935
16central nervous system projection neuron axonogenesis (GO:0021952)4.35592197
17sperm capacitation (GO:0048240)4.18960216
18protein polyglutamylation (GO:0018095)3.86577879
19neuron cell-cell adhesion (GO:0007158)3.82285559
20microtubule polymerization or depolymerization (GO:0031109)3.74878718
21dendritic spine morphogenesis (GO:0060997)3.64095927
22regulation of somitogenesis (GO:0014807)3.62538294
23limb bud formation (GO:0060174)3.62078590
24plasma membrane fusion (GO:0045026)3.61636174
25sperm-egg recognition (GO:0035036)3.53324495
26glial cell proliferation (GO:0014009)3.52469950
27pyrimidine nucleobase catabolic process (GO:0006208)3.51298300
28sexual reproduction (GO:0019953)3.48236111
29cerebral cortex radially oriented cell migration (GO:0021799)3.48016565
30lateral sprouting from an epithelium (GO:0060601)3.41404148
31somite development (GO:0061053)3.40575388
32binding of sperm to zona pellucida (GO:0007339)3.39766558
33calcium ion-dependent exocytosis (GO:0017156)3.37086085
34dendrite morphogenesis (GO:0048813)3.33464355
35head development (GO:0060322)3.30978692
36chromatin silencing (GO:0006342)3.30270547
37central nervous system neuron axonogenesis (GO:0021955)3.29418458
38urogenital system development (GO:0001655)3.27224187
39axonemal dynein complex assembly (GO:0070286)3.20566875
40axon extension (GO:0048675)3.15379433
41regulation of inclusion body assembly (GO:0090083)3.10525099
42spermatogenesis (GO:0007283)3.09151239
43male gamete generation (GO:0048232)3.08408049
44regulation of transcription involved in cell fate commitment (GO:0060850)3.06164638
45cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.04729488
46peptidyl-threonine dephosphorylation (GO:0035970)3.04169694
47gonadal mesoderm development (GO:0007506)3.03403818
48cerebral cortex neuron differentiation (GO:0021895)3.01987944
49negative regulation of gene expression, epigenetic (GO:0045814)2.97893415
50regulation of cilium movement (GO:0003352)2.96376571
51reproduction (GO:0000003)2.96076614
52planar cell polarity pathway involved in neural tube closure (GO:0090179)2.92408087
53multicellular organism reproduction (GO:0032504)2.91125239
54negative regulation of axon extension involved in axon guidance (GO:0048843)2.89415255
55spinal cord development (GO:0021510)2.88285913
56hippo signaling (GO:0035329)2.86943589
57positive regulation of synapse maturation (GO:0090129)2.86657538
58negative regulation of axon extension (GO:0030517)2.86221328
59gamete generation (GO:0007276)2.85000161
60negative regulation of axon guidance (GO:1902668)2.82888091
61gastrulation with mouth forming second (GO:0001702)2.82142541
62outer ear morphogenesis (GO:0042473)2.81696311
63phosphatidylethanolamine biosynthetic process (GO:0006646)2.80960521
64proximal/distal pattern formation (GO:0009954)2.80903468
65establishment of nucleus localization (GO:0040023)2.79776689
66regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.79478367
67ephrin receptor signaling pathway (GO:0048013)2.79446757
68ganglion development (GO:0061548)2.77489115
69lymph vessel development (GO:0001945)2.76881347
70positive regulation of dendrite morphogenesis (GO:0050775)2.75570265
71regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.74269189
72cell-cell recognition (GO:0009988)2.71895160
73rRNA methylation (GO:0031167)2.71355334
74neurofilament cytoskeleton organization (GO:0060052)2.71117924
75protein localization to synapse (GO:0035418)2.70804818
76neuron migration (GO:0001764)2.70698016
77positive regulation of dendritic spine morphogenesis (GO:0061003)2.70270353
78regulation of axon extension involved in axon guidance (GO:0048841)2.69973952
79cranial nerve morphogenesis (GO:0021602)2.69909880
80positive regulation of gastrulation (GO:2000543)2.69624904
81germ cell development (GO:0007281)2.68884725
82mRNA splice site selection (GO:0006376)2.68139527
83regulation of axon guidance (GO:1902667)2.68037705
84neuron projection extension (GO:1990138)2.65994433
85positive regulation of filopodium assembly (GO:0051491)2.65491406
86hippocampus development (GO:0021766)2.65234469
87negative regulation of catenin import into nucleus (GO:0035414)2.64714026
88seminiferous tubule development (GO:0072520)2.64392049
89limb development (GO:0060173)2.63989175
90appendage development (GO:0048736)2.63989175
91negative regulation of histone methylation (GO:0031061)2.63863222
92establishment of tissue polarity (GO:0007164)2.63268636
93establishment of planar polarity (GO:0001736)2.63268636
94regulation of microtubule-based movement (GO:0060632)2.62997963
95regulation of dendritic spine morphogenesis (GO:0061001)2.62582603
96regulation of mesenchymal cell apoptotic process (GO:2001053)2.62447102
97positive regulation of synapse assembly (GO:0051965)2.62272267
98positive regulation of Rab GTPase activity (GO:0032851)2.61414550
99regulation of Rab GTPase activity (GO:0032313)2.61414550
100centriole replication (GO:0007099)2.61335264
101establishment of mitochondrion localization (GO:0051654)2.60747367
102artery development (GO:0060840)2.60714341
103postsynaptic membrane organization (GO:0001941)2.60534840
104cell differentiation involved in metanephros development (GO:0072202)2.60281115
105protein-DNA complex disassembly (GO:0032986)2.58566051
106nucleosome disassembly (GO:0006337)2.58566051
107embryonic foregut morphogenesis (GO:0048617)2.58393523
108cellular process involved in reproduction in multicellular organism (GO:0022412)2.56025989
109protein targeting to Golgi (GO:0000042)2.55740052
110cell proliferation in forebrain (GO:0021846)2.55600305
111metanephric mesenchyme development (GO:0072075)2.55569114
112negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.55371918
113axon extension involved in axon guidance (GO:0048846)2.54843079
114neuron projection extension involved in neuron projection guidance (GO:1902284)2.54843079
115kidney morphogenesis (GO:0060993)2.54791407
116nucleus organization (GO:0006997)2.53406425
117phosphatidylethanolamine metabolic process (GO:0046337)2.53377596
118retrograde transport, vesicle recycling within Golgi (GO:0000301)2.52401998
119negative regulation of microtubule polymerization (GO:0031115)2.52098566
120vocalization behavior (GO:0071625)2.51011949
121regulation of development, heterochronic (GO:0040034)2.49396472
122regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.47953983
123positive regulation of skeletal muscle tissue development (GO:0048643)2.46843966
124negative regulation of axonogenesis (GO:0050771)2.46677149
125cell differentiation in spinal cord (GO:0021515)2.46328465
126nucleobase catabolic process (GO:0046113)2.46141337
127convergent extension (GO:0060026)2.46102109
128spinal cord association neuron differentiation (GO:0021527)2.45225506
129establishment of protein localization to Golgi (GO:0072600)2.44929171
130atrial septum morphogenesis (GO:0060413)2.44570833
131forebrain neuron differentiation (GO:0021879)2.44222892
132coronary vasculature morphogenesis (GO:0060977)2.43676442
133mitochondrion transport along microtubule (GO:0047497)2.43612953
134establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.43612953
135pre-miRNA processing (GO:0031054)2.41570263
136cerebellum development (GO:0021549)2.40982030
137apical protein localization (GO:0045176)2.40109946
138semaphorin-plexin signaling pathway (GO:0071526)2.37836488
139kidney mesenchyme development (GO:0072074)2.36656352
140cardiac ventricle formation (GO:0003211)2.35865784
141polarized epithelial cell differentiation (GO:0030859)2.35742492
142axonogenesis (GO:0007409)2.35012207
143peptidyl-arginine N-methylation (GO:0035246)2.35010745
144peptidyl-arginine methylation (GO:0018216)2.35010745
145regulation of NFAT protein import into nucleus (GO:0051532)2.34919824
146microtubule depolymerization (GO:0007019)2.34159500
147mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.32659907
148innervation (GO:0060384)2.32513293
149regulation of neuron migration (GO:2001222)2.32134192
150cochlea morphogenesis (GO:0090103)2.31899386
151regulation of synapse assembly (GO:0051963)2.30675147
152presynaptic membrane organization (GO:0097090)2.30597409
153lens morphogenesis in camera-type eye (GO:0002089)2.29970021
154forebrain development (GO:0030900)2.29233098
155presynaptic membrane assembly (GO:0097105)2.27609138
156glutamate receptor signaling pathway (GO:0007215)2.27505713
157regulation of glutamate receptor signaling pathway (GO:1900449)2.26853209
158camera-type eye morphogenesis (GO:0048593)2.26775524
159ionotropic glutamate receptor signaling pathway (GO:0035235)2.25505704
160exploration behavior (GO:0035640)2.24565871
161cerebellar Purkinje cell differentiation (GO:0021702)2.23790934
162cochlea development (GO:0090102)2.23255856
163regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.21802967
164regulation of axon extension (GO:0030516)2.21093296
165eyelid development in camera-type eye (GO:0061029)2.20879358
166neuron projection morphogenesis (GO:0048812)2.20672028
167dendritic spine organization (GO:0097061)2.19875414
168neuronal stem cell maintenance (GO:0097150)2.19085611
169olfactory bulb development (GO:0021772)2.19084620
170positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19082072
171developmental cell growth (GO:0048588)2.19060061
172locomotory exploration behavior (GO:0035641)2.18666805

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.86914036
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.56657597
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.05876124
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.04039236
5* EZH2_27304074_Chip-Seq_ESCs_Mouse2.94243612
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.56362912
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.56362912
8* RNF2_27304074_Chip-Seq_ESCs_Mouse2.40622191
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.39003746
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37844668
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.37454329
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33480268
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31439045
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.29515443
15* CBX2_27304074_Chip-Seq_ESCs_Mouse2.28762330
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19277764
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.18869837
18GBX2_23144817_ChIP-Seq_PC3_Human2.16503602
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.11223254
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.09329414
21ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.08940897
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.08536367
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.07607473
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.03911933
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03823676
26* RING1B_27294783_Chip-Seq_NPCs_Mouse2.02862122
27TP63_19390658_ChIP-ChIP_HaCaT_Human1.96611436
28HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.96514024
29TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.92448584
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88726200
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88389829
32MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81936550
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.78889074
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77569139
35HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.74720321
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.73590310
37EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71323920
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.71065129
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.68823951
40ZFP281_18757296_ChIP-ChIP_E14_Mouse1.66862555
41* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.65403056
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64747503
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64017298
44ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60099117
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58859844
46RNF2_27304074_Chip-Seq_NSC_Mouse1.58636062
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.54437221
48* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54163944
49ZNF274_21170338_ChIP-Seq_K562_Hela1.52121132
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.50331614
51TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49938885
52POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.49938885
53* REST_21632747_ChIP-Seq_MESCs_Mouse1.47417108
54DROSHA_22980978_ChIP-Seq_HELA_Human1.43794380
55FUS_26573619_Chip-Seq_HEK293_Human1.42640921
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.41595094
57SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.40309795
58* ISL1_27105846_Chip-Seq_CPCs_Mouse1.37638839
59CTCF_27219007_Chip-Seq_Bcells_Human1.37602738
60CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36575231
61TAF15_26573619_Chip-Seq_HEK293_Human1.35474504
62CBP_20019798_ChIP-Seq_JUKART_Human1.33997630
63IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33997630
64KDM2B_26808549_Chip-Seq_K562_Human1.29940185
65OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.28046105
66WDR5_24793694_ChIP-Seq_LNCAP_Human1.26776267
67AR_21572438_ChIP-Seq_LNCaP_Human1.25538075
68DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24561908
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.23433383
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.20522265
71KDM2B_26808549_Chip-Seq_JURKAT_Human1.20199718
72* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19045025
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.18719840
74ERG_21242973_ChIP-ChIP_JURKAT_Human1.16709002
75SMAD3_21741376_ChIP-Seq_EPCs_Human1.15382446
76* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.14337514
77ARNT_22903824_ChIP-Seq_MCF-7_Human1.12373868
78* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11848431
79* RUNX1_26923725_Chip-Seq_HPCs_Mouse1.10530405
80AHR_22903824_ChIP-Seq_MCF-7_Human1.09841203
81* AR_25329375_ChIP-Seq_VCAP_Human1.09483767
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09017082
83SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08883009
84BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08270481
85* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07703543
86P300_19829295_ChIP-Seq_ESCs_Human1.06912983
87TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05186219
88PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04227773
89YAP1_20516196_ChIP-Seq_MESCs_Mouse1.04128997
90REST_18959480_ChIP-ChIP_MESCs_Mouse1.02412349
91SOX2_16153702_ChIP-ChIP_HESCs_Human1.01679839
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99596009
93* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99557907
94KDM2B_26808549_Chip-Seq_SUP-B15_Human0.99340364
95* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.99307416
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.99200205
97SMAD3_21741376_ChIP-Seq_ESCs_Human0.98726209
98SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98163990
99SMAD4_21799915_ChIP-Seq_A2780_Human0.97639870
100TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96449342
101* KDM2B_26808549_Chip-Seq_DND41_Human0.96059770
102AR_19668381_ChIP-Seq_PC3_Human0.95460984
103SOX9_26525672_Chip-Seq_HEART_Mouse0.95083268
104SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94319189
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.93501012
106* ZNF217_24962896_ChIP-Seq_MCF-7_Human0.93382998
107VDR_22108803_ChIP-Seq_LS180_Human0.93209589
108* ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92881666
109* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.91661346
110* MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.89923871
111MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89809288
112* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89283763
113SOX2_21211035_ChIP-Seq_LN229_Gbm0.88747067
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.88728497
115CDX2_19796622_ChIP-Seq_MESCs_Mouse0.88606968
116* RUNX2_22187159_ChIP-Seq_PCA_Human0.88283566
117* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88274991
118* TP53_18474530_ChIP-ChIP_U2OS_Human0.87792049
119PIAS1_25552417_ChIP-Seq_VCAP_Human0.86985810
120ER_23166858_ChIP-Seq_MCF-7_Human0.86926501
121* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.84241199
122IGF1R_20145208_ChIP-Seq_DFB_Human0.80895215
123EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.80287533
124THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.79706670
125TDRD3_21172665_ChIP-Seq_MCF-7_Human0.79624270
126* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.79115593
127SMAD4_21741376_ChIP-Seq_EPCs_Human0.78263899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization4.67313103
2MP0003880_abnormal_central_pattern3.83452196
3MP0000778_abnormal_nervous_system3.13841097
4MP0000566_synostosis3.01793320
5MP0000537_abnormal_urethra_morphology2.90135114
6MP0002822_catalepsy2.62023925
7MP0003122_maternal_imprinting2.42107799
8MP0004859_abnormal_synaptic_plasticity2.40799408
9MP0010030_abnormal_orbit_morphology2.29641468
10MP0003121_genomic_imprinting2.16506345
11MP0004270_analgesia2.16210453
12MP0003698_abnormal_male_reproductive2.10509930
13MP0003385_abnormal_body_wall2.08952371
14MP0005423_abnormal_somatic_nervous2.05225088
15MP0009053_abnormal_anal_canal2.05171461
16MP0003787_abnormal_imprinting2.01933030
17MP0000049_abnormal_middle_ear1.94096841
18MP0005623_abnormal_meninges_morphology1.89166850
19MP0008789_abnormal_olfactory_epithelium1.88207463
20MP0005377_hearing/vestibular/ear_phenot1.87424232
21MP0003878_abnormal_ear_physiology1.87424232
22MP0003938_abnormal_ear_development1.81870788
23MP0002184_abnormal_innervation1.78743540
24MP0003861_abnormal_nervous_system1.75793381
25MP0003119_abnormal_digestive_system1.73539940
26MP0003635_abnormal_synaptic_transmissio1.71732764
27MP0006292_abnormal_olfactory_placode1.68405599
28MP0001188_hyperpigmentation1.67326239
29MP0001929_abnormal_gametogenesis1.66199023
30MP0000569_abnormal_digit_pigmentation1.65733684
31MP0003942_abnormal_urinary_system1.65147391
32MP0001879_abnormal_lymphatic_vessel1.62075430
33MP0002102_abnormal_ear_morphology1.60944818
34MP0002653_abnormal_ependyma_morphology1.60446715
35MP0002063_abnormal_learning/memory/cond1.60312972
36MP0009250_abnormal_appendicular_skeleto1.57065502
37MP0003755_abnormal_palate_morphology1.54954601
38MP0003315_abnormal_perineum_morphology1.53991504
39MP0003890_abnormal_embryonic-extraembry1.50745870
40MP0005499_abnormal_olfactory_system1.50449587
41MP0005394_taste/olfaction_phenotype1.50449587
42MP0005187_abnormal_penis_morphology1.49052248
43MP0003937_abnormal_limbs/digits/tail_de1.49022082
44MP0003123_paternal_imprinting1.46386032
45MP0000955_abnormal_spinal_cord1.45569132
46MP0000534_abnormal_ureter_morphology1.45321407
47MP0006276_abnormal_autonomic_nervous1.42269413
48MP0002282_abnormal_trachea_morphology1.42176232
49MP0000631_abnormal_neuroendocrine_gland1.40651690
50MP0002932_abnormal_joint_morphology1.39460919
51MP0005248_abnormal_Harderian_gland1.37552399
52MP0003136_yellow_coat_color1.36961954
53MP0002116_abnormal_craniofacial_bone1.36406928
54MP0002152_abnormal_brain_morphology1.35218405
55MP0002249_abnormal_larynx_morphology1.34942620
56MP0000733_abnormal_muscle_development1.34521531
57MP0002751_abnormal_autonomic_nervous1.34306152
58MP0010368_abnormal_lymphatic_system1.34253757
59MP0005670_abnormal_white_adipose1.33124381
60MP0001529_abnormal_vocalization1.31987213
61MP0003935_abnormal_craniofacial_develop1.31783512
62MP0002233_abnormal_nose_morphology1.30722647
63MP0003115_abnormal_respiratory_system1.28659326
64MP0000428_abnormal_craniofacial_morphol1.28390194
65MP0002161_abnormal_fertility/fecundity1.27297555
66MP0002734_abnormal_mechanical_nocicepti1.26678082
67MP0004811_abnormal_neuron_physiology1.22914413
68MP0002882_abnormal_neuron_morphology1.20658469
69MP0004742_abnormal_vestibular_system1.18246224
70MP0002081_perinatal_lethality1.17560591
71MP0004858_abnormal_nervous_system1.16897304
72MP0004134_abnormal_chest_morphology1.16361303
73MP0009379_abnormal_foot_pigmentation1.16236697
74MP0004885_abnormal_endolymph1.14143940
75MP0003011_delayed_dark_adaptation1.13367984
76MP0000516_abnormal_urinary_system1.11837621
77MP0005367_renal/urinary_system_phenotyp1.11837621
78MP0002938_white_spotting1.10961455
79MP0002572_abnormal_emotion/affect_behav1.09520799
80MP0009745_abnormal_behavioral_response1.09394870
81MP0001486_abnormal_startle_reflex1.09258552
82MP0002557_abnormal_social/conspecific_i1.08946370
83MP0008995_early_reproductive_senescence1.06954980
84MP0009384_cardiac_valve_regurgitation1.06798185
85MP0002114_abnormal_axial_skeleton1.06521440
86MP0000678_abnormal_parathyroid_gland1.05556436
87MP0003283_abnormal_digestive_organ1.04224691
88MP0002210_abnormal_sex_determination1.03982404
89MP0001348_abnormal_lacrimal_gland1.03843791
90MP0005076_abnormal_cell_differentiation1.03286724
91MP0001485_abnormal_pinna_reflex1.02769767
92MP0005391_vision/eye_phenotype1.00359222
93MP0005409_darkened_coat_color0.99899331
94MP0002084_abnormal_developmental_patter0.99508321
95MP0000432_abnormal_head_morphology0.98542820
96MP0002127_abnormal_cardiovascular_syste0.98523134
97MP0001299_abnormal_eye_distance/0.98323189
98MP0002064_seizures0.97558662
99MP0001286_abnormal_eye_development0.97278989
100MP0002085_abnormal_embryonic_tissue0.97053658
101MP0002234_abnormal_pharynx_morphology0.94950149
102MP0002752_abnormal_somatic_nervous0.94652771
103MP0004233_abnormal_muscle_weight0.92381663
104MP0002092_abnormal_eye_morphology0.91826372
105MP0001968_abnormal_touch/_nociception0.91198353
106MP0000026_abnormal_inner_ear0.91015209
107MP0003718_maternal_effect0.88517830
108MP0001340_abnormal_eyelid_morphology0.87331856
109MP0001145_abnormal_male_reproductive0.86790311
110MP0001963_abnormal_hearing_physiology0.86119242
111MP0005503_abnormal_tendon_morphology0.85657643
112MP0004133_heterotaxia0.83642566
113MP0002177_abnormal_outer_ear0.82676481
114MP0002733_abnormal_thermal_nociception0.82498295
115MP0000653_abnormal_sex_gland0.82315877
116MP0009780_abnormal_chondrocyte_physiolo0.77969249
117MP0002697_abnormal_eye_size0.77833824
118MP0001984_abnormal_olfaction0.77791585
119MP0000462_abnormal_digestive_system0.77479570
120MP0002067_abnormal_sensory_capabilities0.77132009
121MP0001346_abnormal_lacrimal_gland0.76841265
122MP0001293_anophthalmia0.76836388
123MP0002735_abnormal_chemical_nociception0.76764620
124MP0003567_abnormal_fetal_cardiomyocyte0.76109297
125MP0002272_abnormal_nervous_system0.75329603
126MP0004197_abnormal_fetal_growth/weight/0.74888928
127MP0005171_absent_coat_pigmentation0.74492062
128MP0002163_abnormal_gland_morphology0.73593699

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.81981562
2Short 4th metacarpal (HP:0010044)3.81981562
3Severe visual impairment (HP:0001141)3.28506481
4Shallow orbits (HP:0000586)3.05401380
5Abnormality of the 4th metacarpal (HP:0010012)2.98195878
6Hepatoblastoma (HP:0002884)2.86942904
7Tubulointerstitial nephritis (HP:0001970)2.76451515
8Bony spicule pigmentary retinopathy (HP:0007737)2.68620286
9Hypoplastic ischia (HP:0003175)2.65869455
10Renal duplication (HP:0000075)2.59013294
11Dynein arm defect of respiratory motile cilia (HP:0012255)2.55026386
12Absent/shortened dynein arms (HP:0200106)2.55026386
13Renal dysplasia (HP:0000110)2.54592183
14Abnormality of the ischium (HP:0003174)2.52416127
15Facial hemangioma (HP:0000329)2.45773903
16Volvulus (HP:0002580)2.41194638
17Bell-shaped thorax (HP:0001591)2.37244920
18Hyperacusis (HP:0010780)2.35531032
19Myokymia (HP:0002411)2.35011930
20Buphthalmos (HP:0000557)2.29044134
21Amyotrophic lateral sclerosis (HP:0007354)2.28243326
22Nephronophthisis (HP:0000090)2.27471109
23Insidious onset (HP:0003587)2.25490565
24Termporal pattern (HP:0011008)2.25490565
25Supranuclear gaze palsy (HP:0000605)2.23838725
26Midline defect of the nose (HP:0004122)2.21591456
27Morphological abnormality of the middle ear (HP:0008609)2.20874303
28Optic nerve hypoplasia (HP:0000609)2.17863305
29Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.17835784
30Short 1st metacarpal (HP:0010034)2.17835784
31Abnormality of the corticospinal tract (HP:0002492)2.15978663
32Abnormal rod and cone electroretinograms (HP:0008323)2.15397806
33Sacral dimple (HP:0000960)2.11633088
34Abnormality of the phalanges of the hallux (HP:0010057)2.11049869
35Abnormality of the distal phalanx of the thumb (HP:0009617)2.10036369
36Attenuation of retinal blood vessels (HP:0007843)2.09731259
37Impulsivity (HP:0100710)2.09091358
38Drooling (HP:0002307)2.09055797
39Excessive salivation (HP:0003781)2.09055797
40Tented upper lip vermilion (HP:0010804)2.07685069
41Infertility (HP:0000789)2.06992574
42Asymmetry of the thorax (HP:0001555)2.02739189
43Overriding aorta (HP:0002623)2.00086615
44Insomnia (HP:0100785)1.98139107
45Coronal craniosynostosis (HP:0004440)1.98063143
46Cutaneous finger syndactyly (HP:0010554)1.97906175
47Abnormality of the labia minora (HP:0012880)1.97566396
48Chin dimple (HP:0010751)1.96781142
49Abnormality of the aortic arch (HP:0012303)1.96366950
50Trigonocephaly (HP:0000243)1.94605945
51Failure to thrive in infancy (HP:0001531)1.94049954
52Aplasia/Hypoplasia of the sternum (HP:0006714)1.93510666
53Abnormal respiratory motile cilium morphology (HP:0005938)1.91873443
54Abnormal respiratory epithelium morphology (HP:0012253)1.91873443
55Short phalanx of the thumb (HP:0009660)1.91793923
56Male infertility (HP:0003251)1.91576207
57Flat cornea (HP:0007720)1.90779277
58Abnormality of the 2nd finger (HP:0004100)1.90768115
59Degeneration of the lateral corticospinal tracts (HP:0002314)1.90641841
60Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90641841
61Germ cell neoplasia (HP:0100728)1.88437508
62Abnormality of the pubic bones (HP:0003172)1.88271641
63Abnormal ciliary motility (HP:0012262)1.88217742
64Vitreoretinal degeneration (HP:0000655)1.88098538
65Shoulder girdle muscle weakness (HP:0003547)1.86450229
66Chronic hepatic failure (HP:0100626)1.85858879
67Pachygyria (HP:0001302)1.85624701
68Broad ribs (HP:0000885)1.83936893
69Septo-optic dysplasia (HP:0100842)1.83632389
70Vertebral clefting (HP:0008428)1.83439467
71Abnormality of the 1st metacarpal (HP:0010009)1.82963316
72Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.82574296
73Lissencephaly (HP:0001339)1.82545756
74Abnormality of the renal medulla (HP:0100957)1.82463706
75Abdominal situs inversus (HP:0003363)1.82331025
76Abnormality of abdominal situs (HP:0011620)1.82331025
77Renovascular hypertension (HP:0100817)1.82019467
78Inappropriate behavior (HP:0000719)1.81276280
79Hypoplastic iliac wings (HP:0002866)1.80004179
80Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.79665245
81Aqueductal stenosis (HP:0002410)1.79412837
82Neonatal short-limb short stature (HP:0008921)1.79365749
83Neoplasm of the heart (HP:0100544)1.79041280
84Pointed chin (HP:0000307)1.78852935
85Double outlet right ventricle (HP:0001719)1.78826888
86Congenital malformation of the right heart (HP:0011723)1.78826888
87Increased nuchal translucency (HP:0010880)1.78328773
88Esophageal atresia (HP:0002032)1.77921252
89Narrow nasal bridge (HP:0000446)1.77891317
90Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.77488446
91Focal seizures (HP:0007359)1.76033906
92Retinal dysplasia (HP:0007973)1.75865172
93Exotropia (HP:0000577)1.75205648
94Oligodactyly (HP:0012165)1.75154285
95Shawl scrotum (HP:0000049)1.74500763
96Short ribs (HP:0000773)1.74102389
97Renal hypoplasia (HP:0000089)1.74036661
98Progressive cerebellar ataxia (HP:0002073)1.73866317
99Aplasia/Hypoplasia of the earlobes (HP:0009906)1.73394230
100Down-sloping shoulders (HP:0200021)1.72803436
101Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.72700448
102Abnormality of femoral epiphyses (HP:0006499)1.72700448
103Cutaneous syndactyly (HP:0012725)1.71497016
104Alacrima (HP:0000522)1.71455972
105Elfin facies (HP:0004428)1.70093157
106Abnormality of the diencephalon (HP:0010662)1.70084983
107Abnormality of the middle phalanges of the toes (HP:0010183)1.69347326
108Vesicoureteral reflux (HP:0000076)1.68659804
109Abnormal respiratory motile cilium physiology (HP:0012261)1.68183993
110Amblyopia (HP:0000646)1.68040362
111Deviation of the hallux (HP:0010051)1.67226588
112Sclerocornea (HP:0000647)1.66671503
113Microglossia (HP:0000171)1.66096497
114Anteriorly placed anus (HP:0001545)1.65887053
115Anencephaly (HP:0002323)1.65579186
116Abnormality of the parathyroid morphology (HP:0011766)1.65553191
117Epileptic encephalopathy (HP:0200134)1.65440973
118Obstructive sleep apnea (HP:0002870)1.65342991
119Hydroureter (HP:0000072)1.65143415
120Short philtrum (HP:0000322)1.65105115
121Abnormality of the intervertebral disk (HP:0005108)1.64392840
122Bilateral microphthalmos (HP:0007633)1.64248028
123Anophthalmia (HP:0000528)1.64112213
124Concave nail (HP:0001598)1.62320267
125Hypoplastic ilia (HP:0000946)1.61851169
126Anterior segment dysgenesis (HP:0007700)1.61751509
127Sporadic (HP:0003745)1.61554289
128Abnormality of the proximal phalanges of the hand (HP:0009834)1.61143367
129Bladder diverticulum (HP:0000015)1.60992205
130Supernumerary ribs (HP:0005815)1.60859068
131Heterotopia (HP:0002282)1.60745389
132Hallux valgus (HP:0001822)1.60527943
133Oligodactyly (hands) (HP:0001180)1.60429930
134Tubulointerstitial abnormality (HP:0001969)1.59956939
135Focal motor seizures (HP:0011153)1.59644329
136Hypoplastic left heart (HP:0004383)1.59561650
137Gonadotropin excess (HP:0000837)1.59456058
138Patellar dislocation (HP:0002999)1.58320320
139Obsessive-compulsive behavior (HP:0000722)1.57947405
140Cortical dysplasia (HP:0002539)1.57914901
141Abnormality of dentin (HP:0010299)1.56536657
142Wrist flexion contracture (HP:0001239)1.56403858
143Arnold-Chiari malformation (HP:0002308)1.56393160
144Abnormal number of incisors (HP:0011064)1.55854796
145High anterior hairline (HP:0009890)1.55818581
146Intellectual disability, moderate (HP:0002342)1.54903742
147Broad thumb (HP:0011304)1.54639836
148Maternal diabetes (HP:0009800)1.54342026
149Broad-based gait (HP:0002136)1.54202459
150Abnormality of the epiphysis of the femoral head (HP:0010574)1.53422203
151Facial shape deformation (HP:0011334)1.52890370
152Potter facies (HP:0002009)1.52890370
153Omphalocele (HP:0001539)1.52360143
154Autism (HP:0000717)1.51739730
155Spina bifida occulta (HP:0003298)1.51679021
156Pendular nystagmus (HP:0012043)1.51051732
157Patellar aplasia (HP:0006443)1.50602782
158Increased density of long bones (HP:0006392)1.50526653
159Broad alveolar ridges (HP:0000187)1.50217348
160Apathy (HP:0000741)1.49800228
161Congenital diaphragmatic hernia (HP:0000776)1.49168694
162Cerebral inclusion bodies (HP:0100314)1.48960089
163Abnormality of the parietal bone (HP:0002696)1.48882764
164Preaxial foot polydactyly (HP:0001841)1.48709788
165Abnormality of chromosome segregation (HP:0002916)1.48568152
166Truncus arteriosus (HP:0001660)1.48455804
167Megalocornea (HP:0000485)1.48145998
168Hypoplasia of the brainstem (HP:0002365)1.48062991
169Aplasia/Hypoplasia of the brainstem (HP:0007362)1.48062991

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.54376509
2PLK44.08650465
3MAPK153.21478044
4SIK23.08150904
5EPHB22.75327721
6TESK12.73947628
7ICK2.49224020
8EPHA42.41382044
9PNCK2.34313483
10DYRK22.31923883
11TYRO32.25234376
12CASK2.20562811
13MAP3K42.18036649
14INSRR2.11728544
15ERBB31.99898392
16KSR11.99737956
17MAPK131.99233282
18MAP3K101.95092558
19NTRK21.88192253
20LATS21.84656709
21UHMK11.79055191
22NTRK31.77950590
23DDR21.63104043
24MKNK11.62298125
25MAP4K21.61248978
26TIE11.56463719
27STK381.53610892
28MAP2K71.50429604
29MKNK21.49330446
30STK38L1.46754448
31PAK61.37465528
32DYRK31.30627484
33PDGFRA1.27193517
34PKN11.26851260
35FGR1.23322889
36CSNK1A1L1.19908302
37WNK31.19830390
38PLK21.16326932
39CDK71.14059746
40MAP3K91.12384734
41RPS6KA21.09451444
42FGFR21.09201340
43CDK121.08693910
44MINK11.08108375
45CSNK1G21.07060609
46CAMK1G1.01793042
47DAPK21.00238006
48CSNK1G30.99040854
49LATS10.98471897
50MAP3K60.97133875
51PHKG10.95388881
52PHKG20.95388881
53DYRK1B0.94567259
54WEE10.94205122
55CDK30.93903850
56CAMK1D0.93622710
57LIMK10.91529809
58CDK50.90891563
59WNK10.89331239
60RPS6KC10.83628497
61RPS6KL10.83628497
62DYRK1A0.80171037
63CDK140.80104443
64VRK10.79364901
65PTK2B0.79186763
66STK110.78613557
67NEK20.77709035
68CDK150.77619576
69PRKCG0.77466364
70TGFBR10.77095785
71RPS6KA60.76678949
72BCR0.76467353
73CDK180.76190819
74TAF10.75944985
75RET0.74858620
76RPS6KA10.74643762
77PDGFRB0.74636592
78PAK30.71425634
79PRKD30.69906766
80CSNK1G10.69835170
81CDK11A0.68750153
82SGK2230.68694116
83SGK4940.68694116
84FGFR10.68108083
85MAP2K20.67582237
86MARK20.67393237
87PAK20.67323104
88DMPK0.66736583
89PASK0.65668521
90SRPK10.64022709
91CDC70.62188361
92ROCK20.62053163
93PTK60.60099171
94PRKCZ0.58329719
95CHEK20.58079987
96BMPR1B0.57936031
97ERBB20.57449757
98TRIB30.55170873
99MTOR0.53656380
100ADRBK10.53211244
101SGK20.52584938
102TSSK60.52493341
103NUAK10.51483893
104CDK90.49432215
105BRD40.48688764
106PRKG10.48400845
107IRAK20.47879564
108PLK30.47611302
109MAPK90.47523814
110RPS6KA40.46773850
111RIPK10.46547872
112AKT30.46505276
113EEF2K0.45967269
114KSR20.45905648
115MAP2K40.45476356
116PTK20.44399258
117MAPK80.44283793
118CDK60.43727380
119CDK10.43664342
120ROCK10.42942446
121TNIK0.42460089
122ILK0.41837790
123ALK0.41529643
124GSK3B0.40626969
125CSNK1E0.40184350
126BMX0.39408545
127CAMK2A0.39099861
128NTRK10.38851983
129MAPK140.37693716
130CDK20.37557952
131MAPK10.37524813
132CAMK2B0.37126577
133EPHA30.37122253
134CSNK1D0.36543957
135YES10.36280672
136DAPK10.36129411
137AKT10.35510313
138CDK40.34841268
139MAPK100.34374651
140AURKA0.31685230
141ATM0.30362283

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.64328377
2Axon guidance_Homo sapiens_hsa043602.54838206
3Fatty acid biosynthesis_Homo sapiens_hsa000612.46246582
4Basal cell carcinoma_Homo sapiens_hsa052172.06478920
5Hedgehog signaling pathway_Homo sapiens_hsa043402.00730496
6Hippo signaling pathway_Homo sapiens_hsa043901.66070392
7Nicotine addiction_Homo sapiens_hsa050331.65766785
8Colorectal cancer_Homo sapiens_hsa052101.63089569
9Caffeine metabolism_Homo sapiens_hsa002321.61817580
10Wnt signaling pathway_Homo sapiens_hsa043101.58619501
11Glutamatergic synapse_Homo sapiens_hsa047241.54794015
12Long-term potentiation_Homo sapiens_hsa047201.53784606
13Glioma_Homo sapiens_hsa052141.47595811
14Melanogenesis_Homo sapiens_hsa049161.45895198
15Gap junction_Homo sapiens_hsa045401.44890439
16Dopaminergic synapse_Homo sapiens_hsa047281.43561889
17ErbB signaling pathway_Homo sapiens_hsa040121.42491060
18Circadian entrainment_Homo sapiens_hsa047131.38594819
19Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.38285279
20Renal cell carcinoma_Homo sapiens_hsa052111.37494155
21MicroRNAs in cancer_Homo sapiens_hsa052061.35530314
22Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.35515376
23Endometrial cancer_Homo sapiens_hsa052131.35111064
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.34366504
25Long-term depression_Homo sapiens_hsa047301.29721818
26Viral myocarditis_Homo sapiens_hsa054161.29522194
27Estrogen signaling pathway_Homo sapiens_hsa049151.28482458
28RNA transport_Homo sapiens_hsa030131.25157197
29Cardiac muscle contraction_Homo sapiens_hsa042601.24208140
30Cholinergic synapse_Homo sapiens_hsa047251.23761293
31Dorso-ventral axis formation_Homo sapiens_hsa043201.21028434
32Morphine addiction_Homo sapiens_hsa050321.19823302
33Adherens junction_Homo sapiens_hsa045201.19671811
34Renin secretion_Homo sapiens_hsa049241.19404111
35Chronic myeloid leukemia_Homo sapiens_hsa052201.18466139
36Oocyte meiosis_Homo sapiens_hsa041141.17781105
37Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17587685
38Oxytocin signaling pathway_Homo sapiens_hsa049211.16743646
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16621007
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.16418083
41Amphetamine addiction_Homo sapiens_hsa050311.16094908
42mRNA surveillance pathway_Homo sapiens_hsa030151.15973390
43Notch signaling pathway_Homo sapiens_hsa043301.15736471
44Serotonergic synapse_Homo sapiens_hsa047261.12570672
45Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.12407905
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11428839
47Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.09446108
48ECM-receptor interaction_Homo sapiens_hsa045121.09318798
49VEGF signaling pathway_Homo sapiens_hsa043701.08848862
50GABAergic synapse_Homo sapiens_hsa047271.08702155
51GnRH signaling pathway_Homo sapiens_hsa049121.04150657
52Neurotrophin signaling pathway_Homo sapiens_hsa047221.03191300
53Alcoholism_Homo sapiens_hsa050341.02385500
54Cocaine addiction_Homo sapiens_hsa050301.00164574
55Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99153306
56MAPK signaling pathway_Homo sapiens_hsa040100.98689843
57Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98105985
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.97408070
59Butanoate metabolism_Homo sapiens_hsa006500.97079980
60Prostate cancer_Homo sapiens_hsa052150.94924963
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93689357
62TGF-beta signaling pathway_Homo sapiens_hsa043500.93134488
63Proteoglycans in cancer_Homo sapiens_hsa052050.92900930
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92722745
65Olfactory transduction_Homo sapiens_hsa047400.92479259
66Non-small cell lung cancer_Homo sapiens_hsa052230.92128201
67Rap1 signaling pathway_Homo sapiens_hsa040150.92093398
68Focal adhesion_Homo sapiens_hsa045100.91499360
69Choline metabolism in cancer_Homo sapiens_hsa052310.91448359
70Pathways in cancer_Homo sapiens_hsa052000.91071964
71Pancreatic cancer_Homo sapiens_hsa052120.91044571
72mTOR signaling pathway_Homo sapiens_hsa041500.90945483
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.90420184
74Protein digestion and absorption_Homo sapiens_hsa049740.89761616
75Salivary secretion_Homo sapiens_hsa049700.87352535
76Tight junction_Homo sapiens_hsa045300.87007638
77Spliceosome_Homo sapiens_hsa030400.86997611
78Fanconi anemia pathway_Homo sapiens_hsa034600.86270921
79Regulation of actin cytoskeleton_Homo sapiens_hsa048100.84390383
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.82380890
81Gastric acid secretion_Homo sapiens_hsa049710.82127379
82Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.81969305
83Ras signaling pathway_Homo sapiens_hsa040140.81452152
84Taste transduction_Homo sapiens_hsa047420.81378919
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.81344282
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.80286681
87Dilated cardiomyopathy_Homo sapiens_hsa054140.79798290
88Basal transcription factors_Homo sapiens_hsa030220.78440660
89Small cell lung cancer_Homo sapiens_hsa052220.78307687
90Type II diabetes mellitus_Homo sapiens_hsa049300.78144659
91Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.77238895
92cAMP signaling pathway_Homo sapiens_hsa040240.76771881
93Melanoma_Homo sapiens_hsa052180.76697465
94Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75348720
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.74890053
96Transcriptional misregulation in cancer_Homo sapiens_hsa052020.73228466
97T cell receptor signaling pathway_Homo sapiens_hsa046600.71817652
98Phototransduction_Homo sapiens_hsa047440.71540513
99Synaptic vesicle cycle_Homo sapiens_hsa047210.70962730
100HTLV-I infection_Homo sapiens_hsa051660.70500976
101Steroid biosynthesis_Homo sapiens_hsa001000.70466256
102Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70402765
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70168141
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70129140
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68964170
106Cell cycle_Homo sapiens_hsa041100.67423143
107Ribosome_Homo sapiens_hsa030100.66696327
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66087110
109Insulin secretion_Homo sapiens_hsa049110.65696986
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.65424584
111Calcium signaling pathway_Homo sapiens_hsa040200.63887334
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.63651779
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.63500367
114FoxO signaling pathway_Homo sapiens_hsa040680.61987213
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61762956
116Prolactin signaling pathway_Homo sapiens_hsa049170.60035474
117Bladder cancer_Homo sapiens_hsa052190.58310819
118Lysine degradation_Homo sapiens_hsa003100.56361945
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55304789
120Selenocompound metabolism_Homo sapiens_hsa004500.52012061
121Maturity onset diabetes of the young_Homo sapiens_hsa049500.49212298
122Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.47482087
123PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45622190
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.44727091
125Fatty acid metabolism_Homo sapiens_hsa012120.43916902
126Huntingtons disease_Homo sapiens_hsa050160.43459742

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