MEX3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins with two K homology (KH) RNA-binding domains and a C-terminal RING-finger domain. The protein interacts with mRNA via the KH domains, and the protein shuttles between the nucleus and cytoplasm. Polymorphisms in this gene may contribute to hypertension. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K36 demethylation (GO:0070544)4.71353473
2nuclear pore complex assembly (GO:0051292)4.21592619
3regulation of RNA export from nucleus (GO:0046831)3.99890375
4nuclear pore organization (GO:0006999)3.98666910
5mitotic sister chromatid cohesion (GO:0007064)3.98589504
6protein localization to kinetochore (GO:0034501)3.81873845
7histone H3-K9 demethylation (GO:0033169)3.70741126
8cytoplasmic mRNA processing body assembly (GO:0033962)3.61661405
9histone lysine demethylation (GO:0070076)3.57257817
10hippo signaling (GO:0035329)3.50616882
11DNA synthesis involved in DNA repair (GO:0000731)3.44407781
12regulation of sister chromatid cohesion (GO:0007063)3.43917396
13histone demethylation (GO:0016577)3.39445266
14pore complex assembly (GO:0046931)3.35216678
15regulation of NFAT protein import into nucleus (GO:0051532)3.34674949
16monoubiquitinated protein deubiquitination (GO:0035520)3.32752205
17regulation of nucleobase-containing compound transport (GO:0032239)3.30511110
18regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28861684
19regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.21194031
20regulation of chromatin silencing (GO:0031935)3.10869162
21protein localization to chromosome, centromeric region (GO:0071459)3.10718054
22protein localization to endosome (GO:0036010)3.09447416
23regulation of transforming growth factor beta2 production (GO:0032909)3.06943214
24cell adhesion mediated by integrin (GO:0033627)3.02069695
25planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99206651
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.97649117
27cellular protein complex localization (GO:0034629)2.95713864
28positive regulation of catenin import into nucleus (GO:0035413)2.95051352
29protein dealkylation (GO:0008214)2.94235094
30protein demethylation (GO:0006482)2.94235094
31sister chromatid cohesion (GO:0007062)2.92626003
32positive regulation of SMAD protein import into nucleus (GO:0060391)2.92482436
33regulation of hippo signaling (GO:0035330)2.92032696
34positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.91642860
35positive regulation of mitotic sister chromatid separation (GO:1901970)2.91642860
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.91642860
37NLS-bearing protein import into nucleus (GO:0006607)2.89387679
38chromatin assembly (GO:0031497)2.85571128
39regulation of SMAD protein import into nucleus (GO:0060390)2.83548047
40regulation of gene silencing (GO:0060968)2.79806291
41V(D)J recombination (GO:0033151)2.79468875
42mesodermal cell differentiation (GO:0048333)2.77999750
43heterochromatin organization (GO:0070828)2.77636453
44pre-miRNA processing (GO:0031054)2.77363365
45mitotic chromosome condensation (GO:0007076)2.72771946
46protein complex localization (GO:0031503)2.72629717
47polarized epithelial cell differentiation (GO:0030859)2.71731304
48positive regulation of chromosome segregation (GO:0051984)2.70865059
49embryonic camera-type eye morphogenesis (GO:0048596)2.69844136
50negative regulation of translation, ncRNA-mediated (GO:0040033)2.69125019
51regulation of translation, ncRNA-mediated (GO:0045974)2.69125019
52negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.69125019
53histone H4-K16 acetylation (GO:0043984)2.68603084
54glucocorticoid receptor signaling pathway (GO:0042921)2.68280806
55germ cell migration (GO:0008354)2.68249539
56mRNA stabilization (GO:0048255)2.68199622
57RNA stabilization (GO:0043489)2.68199622
58corticosteroid receptor signaling pathway (GO:0031958)2.67341946
59sister chromatid segregation (GO:0000819)2.67335552
60negative regulation of DNA repair (GO:0045738)2.64924473
61regulation of fibroblast apoptotic process (GO:2000269)2.63518877
62nucleus organization (GO:0006997)2.63430815
63DNA packaging (GO:0006323)2.63046200
64DNA duplex unwinding (GO:0032508)2.54840322
65dorsal/ventral axis specification (GO:0009950)2.53652651
66peptidyl-lysine dimethylation (GO:0018027)2.53027300
67histone H2A monoubiquitination (GO:0035518)2.50494173
68regulation of histone methylation (GO:0031060)2.50293310
69DNA unwinding involved in DNA replication (GO:0006268)2.49881877
70spindle assembly involved in mitosis (GO:0090307)2.49142515
71dosage compensation (GO:0007549)2.48995731
72nuclear envelope disassembly (GO:0051081)2.46558325
73membrane disassembly (GO:0030397)2.46558325
74negative regulation of histone modification (GO:0031057)2.46553751
75microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.46435291
76protein localization to chromosome (GO:0034502)2.45141738
77mitotic nuclear envelope disassembly (GO:0007077)2.44200089
78DNA geometric change (GO:0032392)2.43801790
79protein-DNA complex disassembly (GO:0032986)2.43608906
80nucleosome disassembly (GO:0006337)2.43608906
81regulation of spindle organization (GO:0090224)2.43115456
82regulation of histone H3-K27 methylation (GO:0061085)2.42514245
83DNA conformation change (GO:0071103)2.42512619
84embryonic eye morphogenesis (GO:0048048)2.40920298
85ATP-dependent chromatin remodeling (GO:0043044)2.40325889
86regulation of cell fate specification (GO:0042659)2.38051426
87nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.37440817
88histone H3-K9 methylation (GO:0051567)2.37417059
89hemidesmosome assembly (GO:0031581)2.35663170
90positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.34363902
91epithelial cell differentiation involved in prostate gland development (GO:0060742)2.34211929
92negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.33107871
93regulation of catenin import into nucleus (GO:0035412)2.31851064
94platelet-derived growth factor receptor signaling pathway (GO:0048008)2.30730373
95gastrulation with mouth forming second (GO:0001702)2.30588000
96interferon-gamma secretion (GO:0072643)2.29510619
97negative regulation of histone methylation (GO:0031061)2.29469321
98metaphase plate congression (GO:0051310)2.29348127
99genitalia morphogenesis (GO:0035112)2.29323005
100convergent extension (GO:0060026)2.28678346
101mitotic metaphase plate congression (GO:0007080)2.28656378
102notochord development (GO:0030903)2.27485548
103negative regulation of chromatin modification (GO:1903309)2.26959892
104regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.26727764
105attachment of spindle microtubules to kinetochore (GO:0008608)2.26635910
106histone H4 acetylation (GO:0043967)2.26554939
107embryonic process involved in female pregnancy (GO:0060136)2.26368514
108phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.26225418
109regulation of DNA damage checkpoint (GO:2000001)2.25678880
110DNA replication-dependent nucleosome assembly (GO:0006335)2.24389657
111DNA replication-dependent nucleosome organization (GO:0034723)2.24389657
112positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.24321664
113regulation of histone H3-K9 methylation (GO:0051570)2.23692454
114skin morphogenesis (GO:0043589)2.23346198
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.23258417
116negative regulation of mitotic sister chromatid segregation (GO:0033048)2.23258417
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.23258417
118negative regulation of sister chromatid segregation (GO:0033046)2.23258417
119embryonic foregut morphogenesis (GO:0048617)2.21537294
120regulation of mRNA stability (GO:0043488)2.21242509
121negative regulation of fibroblast apoptotic process (GO:2000270)2.21029123
122cell migration involved in sprouting angiogenesis (GO:0002042)2.19835208
123dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.19663358
124nuclear envelope organization (GO:0006998)2.18097011
125mitotic cytokinesis (GO:0000281)2.17514250
126establishment of endothelial barrier (GO:0061028)2.17366110
127chromosome condensation (GO:0030261)2.16601390
128positive regulation of endothelial cell apoptotic process (GO:2000353)2.15415888
129trophoblast giant cell differentiation (GO:0060707)2.14913731
130gene silencing by RNA (GO:0031047)2.14068428
131wound healing, spreading of epidermal cells (GO:0035313)2.13976544
132chondrocyte proliferation (GO:0035988)2.12246237
133regulation of protein polyubiquitination (GO:1902914)2.11252321
134regulation of centriole replication (GO:0046599)2.10985511
135regulation of RNA stability (GO:0043487)2.10231055
136establishment of mitotic spindle localization (GO:0040001)2.09808881
137mitotic sister chromatid segregation (GO:0000070)2.09622101
138hepatocyte apoptotic process (GO:0097284)2.09419757
139SMAD protein complex assembly (GO:0007183)2.09084629
140endodermal cell differentiation (GO:0035987)2.07485485
141paraxial mesoderm development (GO:0048339)2.07393538
142negative regulation of fatty acid transport (GO:2000192)2.07130584
143wound healing, spreading of cells (GO:0044319)2.06748291
144regulation of gene silencing by RNA (GO:0060966)2.05979607
145regulation of posttranscriptional gene silencing (GO:0060147)2.05979607
146regulation of gene silencing by miRNA (GO:0060964)2.05979607
147lung-associated mesenchyme development (GO:0060484)2.05679217
148chromatin assembly or disassembly (GO:0006333)2.05456493
149regulation of chromosome segregation (GO:0051983)2.04203079
150DNA topological change (GO:0006265)2.03699079
151regulation of mitotic spindle organization (GO:0060236)2.03629749
1523-UTR-mediated mRNA stabilization (GO:0070935)2.03403054
153trophectodermal cell differentiation (GO:0001829)2.00703647
154establishment of apical/basal cell polarity (GO:0035089)2.00055897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.31703718
2EGR1_19374776_ChIP-ChIP_THP-1_Human4.44714463
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.44331771
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse4.28973341
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.23436400
6SALL1_21062744_ChIP-ChIP_HESCs_Human3.29780672
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.25032966
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.66189943
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58701667
10STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.48583330
11RBPJ_22232070_ChIP-Seq_NCS_Mouse2.37433018
12AR_21909140_ChIP-Seq_LNCAP_Human2.35023206
13KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.30292331
14CLOCK_20551151_ChIP-Seq_293T_Human2.22602997
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.21106822
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.14965515
17SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.14093955
18HIF1A_21447827_ChIP-Seq_MCF-7_Human2.08982803
19TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.02141471
20SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.01834712
21FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.95537238
22FOXO3_23340844_ChIP-Seq_DLD1_Human1.83354108
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.82407167
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73192707
25SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.72629048
26* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.70362137
27SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69354518
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69354518
29* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.67884134
30TP63_19390658_ChIP-ChIP_HaCaT_Human1.62866703
31SALL4_18804426_ChIP-ChIP_XEN_Mouse1.60722115
32KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.60510051
33KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.60510051
34KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.60510051
35BRD4_25478319_ChIP-Seq_HGPS_Human1.58826534
36* MYC_22102868_ChIP-Seq_BL_Human1.57809159
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57459864
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.56932571
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52136693
40HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.50844364
41CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.49930100
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45791398
43FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.45163806
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.44703930
45* TCF7_22412390_ChIP-Seq_EML_Mouse1.43718210
46E2F1_21310950_ChIP-Seq_MCF-7_Human1.42072311
47HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.41742978
48KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40675091
49BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.40176459
50* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.39759473
51* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.38182898
52NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.37870894
53MYC_18555785_ChIP-Seq_MESCs_Mouse1.36308867
54* UBF1/2_26484160_Chip-Seq_HMECs_Human1.35443394
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35340792
56PPAR_26484153_Chip-Seq_NCI-H1993_Human1.33708631
57EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.33175072
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32694278
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32577138
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.30416346
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.29947809
62WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29690139
63* CHD1_26751641_Chip-Seq_LNCaP_Human1.29194304
64CJUN_26792858_Chip-Seq_BT549_Human1.28997437
65CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.28335834
66MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28113354
67FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.26021998
68TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25980602
69* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25789248
70* KDM2B_26808549_Chip-Seq_DND41_Human1.25470216
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24333587
72ATF3_27146783_Chip-Seq_COLON_Human1.22918053
73ZNF263_19887448_ChIP-Seq_K562_Human1.21532122
74VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.21354709
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21253106
76ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20075470
77STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19785731
78ISL1_27105846_Chip-Seq_CPCs_Mouse1.15752395
79NOTCH1_21737748_ChIP-Seq_TLL_Human1.14731192
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.13363358
81TP53_16413492_ChIP-PET_HCT116_Human1.12366139
82SOX2_18555785_ChIP-Seq_MESCs_Mouse1.12176001
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.11427839
84ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.11264909
85* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.11222710
86ESR1_21235772_ChIP-Seq_MCF-7_Human1.11211641
87CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10489212
88ZFX_18555785_ChIP-Seq_MESCs_Mouse1.10205989
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09592003
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08795190
91MYB_21317192_ChIP-Seq_ERMYB_Mouse1.08757570
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07684940
93GATA6_25053715_ChIP-Seq_YYC3_Human1.05332213
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.04707752
95PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04625967
96PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04317382
97KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04136537
98ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03937153
99SOX2_16153702_ChIP-ChIP_HESCs_Human1.03924317
100KDM2B_26808549_Chip-Seq_JURKAT_Human1.03773482
101* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02816913
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.02102860
103TCF3_18692474_ChIP-Seq_MESCs_Mouse1.01459295
104NANOG_21062744_ChIP-ChIP_HESCs_Human1.01130993
105ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99704335
106SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.99418644
107BRD4_27068464_Chip-Seq_AML-cells_Mouse0.98900261
108SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97575253
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97348300
110NCOR1_26117541_ChIP-Seq_K562_Human0.96899985
111FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.96898640
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.96680571
113* MYB_26560356_Chip-Seq_TH1_Human0.95735795
114SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95702991
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94836746
116SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.94493555
117NANOG_16153702_ChIP-ChIP_HESCs_Human0.94473050
118TBX3_20139965_ChIP-Seq_ESCs_Mouse0.94042588
119TBX3_20139965_ChIP-Seq_MESCs_Mouse0.93988498
120KDM2B_26808549_Chip-Seq_SUP-B15_Human0.93767886
121NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.92408555
122AR_21572438_ChIP-Seq_LNCaP_Human0.91991032
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.91974766
124MYB_26560356_Chip-Seq_TH2_Human0.91357207
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.91353182
126YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91034657
127TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89819906
128MAF_26560356_Chip-Seq_TH1_Human0.88829038

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.48901620
2MP0010352_gastrointestinal_tract_polyps3.28104846
3MP0010234_abnormal_vibrissa_follicle3.02826799
4MP0005076_abnormal_cell_differentiation2.43490502
5MP0002396_abnormal_hematopoietic_system2.27002673
6MP0000537_abnormal_urethra_morphology2.20744960
7MP0010678_abnormal_skin_adnexa2.19628946
8MP0008438_abnormal_cutaneous_collagen2.08996752
9MP0009053_abnormal_anal_canal2.03032006
10MP0005623_abnormal_meninges_morphology2.02860587
11MP0008877_abnormal_DNA_methylation2.02671711
12MP0006054_spinal_hemorrhage2.00809883
13MP0004272_abnormal_basement_membrane1.93659819
14MP0000733_abnormal_muscle_development1.88792306
15MP0003300_gastrointestinal_ulcer1.88547430
16MP0000383_abnormal_hair_follicle1.82935018
17MP0001849_ear_inflammation1.73937683
18MP0010307_abnormal_tumor_latency1.72497491
19MP0009672_abnormal_birth_weight1.71408308
20MP0004197_abnormal_fetal_growth/weight/1.58912864
21MP0003091_abnormal_cell_migration1.58521590
22MP0003566_abnormal_cell_adhesion1.56731320
23MP0005275_abnormal_skin_tensile1.56161455
24MP0002282_abnormal_trachea_morphology1.54857573
25MP0005409_darkened_coat_color1.52455600
26MP0003941_abnormal_skin_development1.51407311
27MP0004957_abnormal_blastocyst_morpholog1.51162138
28MP0010030_abnormal_orbit_morphology1.49379033
29MP0003937_abnormal_limbs/digits/tail_de1.47843952
30MP0002877_abnormal_melanocyte_morpholog1.46073268
31MP0005023_abnormal_wound_healing1.42728326
32MP0000350_abnormal_cell_proliferation1.42721902
33MP0005187_abnormal_penis_morphology1.42116676
34MP0008057_abnormal_DNA_replication1.39880439
35MP0002086_abnormal_extraembryonic_tissu1.39851246
36MP0002084_abnormal_developmental_patter1.39263299
37MP0003453_abnormal_keratinocyte_physiol1.34798520
38MP0003123_paternal_imprinting1.34783984
39MP0001730_embryonic_growth_arrest1.33157264
40MP0008007_abnormal_cellular_replicative1.32296454
41MP0010094_abnormal_chromosome_stability1.32128470
42MP0001672_abnormal_embryogenesis/_devel1.31977151
43MP0005380_embryogenesis_phenotype1.31977151
44MP0001293_anophthalmia1.31469015
45MP0003303_peritoneal_inflammation1.31176478
46MP0003077_abnormal_cell_cycle1.30814448
47MP0002088_abnormal_embryonic_growth/wei1.30702671
48MP0002092_abnormal_eye_morphology1.30215064
49MP0003984_embryonic_growth_retardation1.30139095
50MP0009278_abnormal_bone_marrow1.29677956
51MP0002796_impaired_skin_barrier1.27811985
52MP0009250_abnormal_appendicular_skeleto1.25219523
53MP0005248_abnormal_Harderian_gland1.24561007
54MP0003755_abnormal_palate_morphology1.24273085
55MP0003828_pulmonary_edema1.23987238
56MP0003763_abnormal_thymus_physiology1.22594709
57MP0000516_abnormal_urinary_system1.21897392
58MP0005367_renal/urinary_system_phenotyp1.21897392
59MP0000579_abnormal_nail_morphology1.21851582
60MP0003111_abnormal_nucleus_morphology1.21727359
61MP0000428_abnormal_craniofacial_morphol1.21311029
62MP0003115_abnormal_respiratory_system1.21285073
63MP0000432_abnormal_head_morphology1.20297450
64MP0002085_abnormal_embryonic_tissue1.19708310
65MP0001915_intracranial_hemorrhage1.18993641
66MP0008058_abnormal_DNA_repair1.18623596
67MP0001697_abnormal_embryo_size1.17232966
68MP0004185_abnormal_adipocyte_glucose1.17167984
69MP0003935_abnormal_craniofacial_develop1.16635468
70MP0005257_abnormal_intraocular_pressure1.16048332
71MP0002697_abnormal_eye_size1.15069153
72MP0001958_emphysema1.12993538
73MP0002925_abnormal_cardiovascular_devel1.12069950
74MP0000647_abnormal_sebaceous_gland1.10070194
75MP0003567_abnormal_fetal_cardiomyocyte1.09775370
76MP0000762_abnormal_tongue_morphology1.09177739
77MP0002060_abnormal_skin_morphology1.08517227
78MP0003121_genomic_imprinting1.07063199
79MP0003693_abnormal_embryo_hatching1.06551957
80MP0003890_abnormal_embryonic-extraembry1.06332592
81MP0002233_abnormal_nose_morphology1.06302721
82MP0005508_abnormal_skeleton_morphology1.05244259
83MP0003448_altered_tumor_morphology1.04015834
84MP0004808_abnormal_hematopoietic_stem1.03052102
85MP0003119_abnormal_digestive_system1.01434640
86MP0005621_abnormal_cell_physiology1.00583325
87MP0003385_abnormal_body_wall0.99644113
88MP0002166_altered_tumor_susceptibility0.99519961
89MP0002089_abnormal_postnatal_growth/wei0.98690930
90MP0003861_abnormal_nervous_system0.98124675
91MP0002009_preneoplasia0.97056075
92MP0000703_abnormal_thymus_morphology0.97008035
93MP0002932_abnormal_joint_morphology0.95885161
94MP0003943_abnormal_hepatobiliary_system0.95187284
95MP0005503_abnormal_tendon_morphology0.94562211
96MP0000490_abnormal_crypts_of0.93021388
97MP0000377_abnormal_hair_follicle0.92283714
98MP0001216_abnormal_epidermal_layer0.91473380
99MP0001340_abnormal_eyelid_morphology0.91270878
100MP0002111_abnormal_tail_morphology0.90931292
101MP0001299_abnormal_eye_distance/0.90401783
102MP0003942_abnormal_urinary_system0.90317040
103MP0002254_reproductive_system_inflammat0.89921029
104MP0009384_cardiac_valve_regurgitation0.89610116
105MP0002896_abnormal_bone_mineralization0.89602460
106MP0000767_abnormal_smooth_muscle0.88732812
107MP0002080_prenatal_lethality0.86665378
108MP0003221_abnormal_cardiomyocyte_apopto0.86218488
109MP0002098_abnormal_vibrissa_morphology0.85921748
110MP0005501_abnormal_skin_physiology0.83864865
111MP0010630_abnormal_cardiac_muscle0.82933262
112MP0008932_abnormal_embryonic_tissue0.82439897
113MP0000313_abnormal_cell_death0.81868655
114MP0009703_decreased_birth_body0.80836293
115MP0002113_abnormal_skeleton_development0.80536839
116MP0001188_hyperpigmentation0.80323663
117MP0002006_tumorigenesis0.79991417
118MP0002210_abnormal_sex_determination0.79677370
119MP0000627_abnormal_mammary_gland0.79666747
120MP0001286_abnormal_eye_development0.79362557
121MP0002081_perinatal_lethality0.79086466
122MP0002114_abnormal_axial_skeleton0.79050901
123MP0004947_skin_inflammation0.79029434
124MP0000534_abnormal_ureter_morphology0.78599684
125MP0002109_abnormal_limb_morphology0.77898121
126MP0004264_abnormal_extraembryonic_tissu0.77880716

Predicted human phenotypes

RankGene SetZ-score
1Short 4th metacarpal (HP:0010044)3.45662621
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.45662621
3Shallow orbits (HP:0000586)3.06196506
4Vertebral arch anomaly (HP:0008438)2.98864224
5Subacute progressive viral hepatitis (HP:0006572)2.87736422
6Premature rupture of membranes (HP:0001788)2.75761934
7Protrusio acetabuli (HP:0003179)2.70680864
8Syringomyelia (HP:0003396)2.53858353
9Spinal cord lesions (HP:0100561)2.53858353
10Nephroblastoma (Wilms tumor) (HP:0002667)2.52652353
11Hematochezia (HP:0002573)2.51936681
12Abnormality of the 4th metacarpal (HP:0010012)2.49204665
13Osteolytic defects of the phalanges of the hand (HP:0009771)2.42292137
14Osteolytic defects of the hand bones (HP:0009699)2.42292137
15Ulnar bowing (HP:0003031)2.41742789
16Embryonal renal neoplasm (HP:0011794)2.40796118
17Mitral valve prolapse (HP:0001634)2.39735314
18Persistence of primary teeth (HP:0006335)2.38250168
19Ankle contracture (HP:0006466)2.37434450
20Absent frontal sinuses (HP:0002688)2.35926473
21Asymmetry of the thorax (HP:0001555)2.34342429
22Volvulus (HP:0002580)2.29963274
23Rectal prolapse (HP:0002035)2.29523474
24Long eyelashes (HP:0000527)2.29080854
25Papillary thyroid carcinoma (HP:0002895)2.27296709
26Deviation of the thumb (HP:0009603)2.26366312
27Cerebral aneurysm (HP:0004944)2.23883326
28Disinhibition (HP:0000734)2.21985967
29Colon cancer (HP:0003003)2.21461950
30Gastrointestinal carcinoma (HP:0002672)2.20188037
31Malignant gastrointestinal tract tumors (HP:0006749)2.20188037
32Abnormality of the fingertips (HP:0001211)2.17547329
33Abnormality of the distal phalanx of the thumb (HP:0009617)2.16084582
34Abnormality of the nasal septum (HP:0000419)2.14794821
35Aortic aneurysm (HP:0004942)2.10149499
36Abnormal hair whorl (HP:0010721)2.09761817
37Dilatation of the ascending aorta (HP:0005111)2.01488530
38Proximal placement of thumb (HP:0009623)2.00383518
39Increased nuchal translucency (HP:0010880)1.99212556
40Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.99069091
41Vascular tortuosity (HP:0004948)1.97682440
42Aortic dissection (HP:0002647)1.96872132
43Arterial tortuosity (HP:0005116)1.96495477
44Acute lymphatic leukemia (HP:0006721)1.95372606
45Arnold-Chiari malformation (HP:0002308)1.93043075
46Genu recurvatum (HP:0002816)1.91878531
47Milia (HP:0001056)1.91406848
48Rhabdomyosarcoma (HP:0002859)1.91144284
49Medulloblastoma (HP:0002885)1.89739754
50Atrophic scars (HP:0001075)1.89322266
51Basal cell carcinoma (HP:0002671)1.88932622
52Broad thumb (HP:0011304)1.88453542
53Increased density of long bones (HP:0006392)1.87821172
54Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.87551963
55Overgrowth (HP:0001548)1.86493479
56Selective tooth agenesis (HP:0001592)1.85580691
57Aplasia/Hypoplasia of the sternum (HP:0006714)1.85401956
58Missing ribs (HP:0000921)1.84109019
59Narrow palate (HP:0000189)1.83909746
60Hypoplastic labia majora (HP:0000059)1.83552593
61Acute myeloid leukemia (HP:0004808)1.83095916
62Shoulder girdle muscle weakness (HP:0003547)1.82677710
63Deep palmar crease (HP:0006191)1.82505925
64Transitional cell carcinoma of the bladder (HP:0006740)1.82471813
65Hepatoblastoma (HP:0002884)1.82332632
66Large earlobe (HP:0009748)1.82154404
67Coronal craniosynostosis (HP:0004440)1.82114997
68Wormian bones (HP:0002645)1.81923801
69Germ cell neoplasia (HP:0100728)1.81804302
70Mesomelia (HP:0003027)1.81474331
71Obsessive-compulsive behavior (HP:0000722)1.80353470
72Cervical subluxation (HP:0003308)1.79166825
73Abnormality of the 2nd finger (HP:0004100)1.79127901
74Limited elbow extension (HP:0001377)1.77975936
75Wide nose (HP:0000445)1.77695221
76Deviation of the hallux (HP:0010051)1.77066077
77Hallux valgus (HP:0001822)1.75807125
78Biliary tract neoplasm (HP:0100574)1.74381483
79Abnormality of chromosome segregation (HP:0002916)1.74069318
80Macroorchidism (HP:0000053)1.73912295
81Peritonitis (HP:0002586)1.72798036
82Atresia of the external auditory canal (HP:0000413)1.72245338
83Facial hemangioma (HP:0000329)1.71764515
84Capillary hemangiomas (HP:0005306)1.71492216
85Ankyloglossia (HP:0010296)1.71169464
86Sandal gap (HP:0001852)1.71067729
87Bladder carcinoma (HP:0002862)1.71013322
88Bladder neoplasm (HP:0009725)1.71013322
89Midline defect of the nose (HP:0004122)1.70749140
90Viral hepatitis (HP:0006562)1.70455072
91Uterine leiomyosarcoma (HP:0002891)1.70311478
92Leiomyosarcoma (HP:0100243)1.70311478
93Buphthalmos (HP:0000557)1.70120139
94Curly hair (HP:0002212)1.69982713
95Termporal pattern (HP:0011008)1.68748087
96Insidious onset (HP:0003587)1.68748087
97Relative macrocephaly (HP:0004482)1.68680182
98Heterotopia (HP:0002282)1.67715044
99Thin bony cortex (HP:0002753)1.67474669
100Camptodactyly of toe (HP:0001836)1.67183920
101Gonadotropin excess (HP:0000837)1.65771782
102Skull defect (HP:0001362)1.65713263
103Sparse scalp hair (HP:0002209)1.65376768
104Truncal obesity (HP:0001956)1.65257565
105Exostoses (HP:0100777)1.64139942
106Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.62958841
107Renal cell carcinoma (HP:0005584)1.62919055
108Myelomeningocele (HP:0002475)1.62482813
109Menstrual irregularities (HP:0000858)1.61739152
110Abnormality of the labia majora (HP:0012881)1.61613816
111Abnormality of the peritoneum (HP:0002585)1.61467151
112Broad palm (HP:0001169)1.61199670
113Tibial bowing (HP:0002982)1.60956028
114Abnormality of the frontal sinuses (HP:0002687)1.59651462
1152-3 toe syndactyly (HP:0004691)1.59629651
116Spastic diplegia (HP:0001264)1.59320738
117Trigonocephaly (HP:0000243)1.59055964
118Metaphyseal cupping (HP:0003021)1.58937870
119Cutaneous melanoma (HP:0012056)1.58641624
120Micronodular cirrhosis (HP:0001413)1.58497722
121Neoplasm of the oral cavity (HP:0100649)1.58411503
122Abnormality of the parietal bone (HP:0002696)1.57958709
123Anal stenosis (HP:0002025)1.57774291
124Broad phalanges of the hand (HP:0009768)1.57410544
125Abnormality of oral frenula (HP:0000190)1.57318054
126Abnormality of the phalanges of the hallux (HP:0010057)1.57308613
127Abnormality of the calcaneus (HP:0008364)1.57149805
128Uterine neoplasm (HP:0010784)1.56586237
129Overlapping toe (HP:0001845)1.56375111
130Esophageal atresia (HP:0002032)1.55892874
131Abnormality of the salivary glands (HP:0010286)1.55577103
132Dislocated radial head (HP:0003083)1.55014541
133Short humerus (HP:0005792)1.54801429
134Abnormal lung lobation (HP:0002101)1.54225553
135Neoplasm of striated muscle (HP:0009728)1.53802661
136Deep philtrum (HP:0002002)1.53701200
137Broad finger (HP:0001500)1.53222579
138Hypoplasia of the maxilla (HP:0000327)1.52651661
139Abnormality of the epiphyses of the hand (HP:0005924)1.51465875
140Long palpebral fissure (HP:0000637)1.51137878
141Neonatal short-limb short stature (HP:0008921)1.50887733
142Thoracolumbar scoliosis (HP:0002944)1.50604929
143Broad long bones (HP:0005622)1.50530463
144Cystic hygroma (HP:0000476)1.50410823
145Astrocytoma (HP:0009592)1.50410299
146Abnormality of the astrocytes (HP:0100707)1.50410299
147Omphalocele (HP:0001539)1.50405376
148Fused cervical vertebrae (HP:0002949)1.50314333
149Broad phalanx (HP:0006009)1.50175380
150Wrist flexion contracture (HP:0001239)1.49176591
151Cubitus valgus (HP:0002967)1.48856190
152Abnormality of the distal phalanges of the toes (HP:0010182)1.48592243
153Bicuspid aortic valve (HP:0001647)1.47897034
154Cafe-au-lait spot (HP:0000957)1.47834080
155Abnormality of the nasolacrimal system (HP:0000614)1.47348176
15611 pairs of ribs (HP:0000878)1.47155104
157Epiphyseal dysplasia (HP:0002656)1.46916859
158Pelvic girdle muscle weakness (HP:0003749)1.46659147
159Cutaneous syndactyly (HP:0012725)1.46555988
160Short nail (HP:0001799)1.46427957
161Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.46238473
162Low anterior hairline (HP:0000294)1.45754606
163High anterior hairline (HP:0009890)1.45506693

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD43.92044871
2PRPF4B3.28655255
3LATS13.17611053
4MAP3K102.97267325
5PNCK2.77189502
6STK32.70351376
7CDK122.59085316
8STK102.19286815
9CAMK1G2.07785250
10PKN22.03066774
11NLK1.98635853
12EEF2K1.96648636
13DDR21.95017113
14CDC71.91181127
15PLK41.84322070
16TRIB31.82109031
17NEK21.79604016
18RPS6KA41.79259285
19CDK61.78364081
20FGFR21.67766136
21PDGFRA1.66304421
22PTK61.65676111
23EPHA21.60709639
24TTN1.59732915
25LRRK21.55578591
26BMX1.47479541
27ERBB31.46780793
28MET1.44029213
29AKT31.39830754
30TAF11.38666837
31MELK1.38200444
32RIPK11.34454901
33YES11.33298904
34STK38L1.32654193
35PDGFRB1.29670207
36PAK21.29381683
37TNIK1.29114141
38RPS6KB21.28489766
39MAP3K81.25969269
40LATS21.25552174
41SCYL21.22668352
42MAP3K91.22378725
43TGFBR11.21158422
44SMG11.19431813
45FGFR41.17707601
46FGFR11.16546869
47FGFR31.15486215
48MAP3K131.13558103
49MST41.11484414
50PAK41.10743175
51ALK1.10152812
52MTOR1.09950999
53CDK41.09169514
54DMPK1.07152201
55PIM11.04527422
56NEK91.03335954
57CHUK1.02367779
58SGK21.01420254
59GSK3A1.00160622
60WNK10.99954117
61TYRO30.99737204
62FRK0.98785300
63MKNK10.98509676
64CSNK1A1L0.97800152
65MAP3K30.94561953
66TGFBR20.92643805
67WEE10.92369110
68DYRK30.91586446
69STK240.91336472
70TTK0.90178082
71PLK30.89890844
72PTK20.88182462
73SGK30.87894735
74ERBB40.86620992
75EPHB10.86299784
76KSR20.85905748
77AURKB0.84899533
78BRSK20.84076599
79TRPM70.83785526
80ACVR1B0.83307270
81ICK0.82612482
82MARK30.81221981
83EIF2AK30.81139294
84CHEK10.79214345
85FER0.78585699
86EPHB20.74196129
87MARK20.71447358
88CHEK20.70794486
89STK40.70651961
90NUAK10.69875003
91CDK70.67174897
92CDK90.66152670
93ATM0.65313576
94MKNK20.64874425
95DYRK1B0.62104242
96CSNK1D0.62018288
97SGK2230.61691552
98SGK4940.61691552
99PASK0.61484886
100MST1R0.60094568
101SRPK10.60031590
102CSNK1G10.58857307
103CDK190.58002488
104JAK30.57942644
105PLK10.56444896
106CDK30.56241166
107SIK10.56149709
108MAP3K140.55811327
109RET0.55515528
110CSF1R0.55310278
111MAP3K20.55303099
112TESK10.54530433
113CDK20.52954013
114BRAF0.51830675
115TSSK60.51309141
116KSR10.51115452
117INSR0.49916465
118FGR0.49325644
119CSK0.49034582
120EPHA30.48805683
121IRAK20.48773648
122NEK60.47605934
123RPS6KA50.46986676
124EGFR0.46257813
125RPS6KA10.45754517
126RPS6KB10.45104175
127MOS0.44763806
128MAPK100.44368739
129CDK10.43727645
130ABL10.41856541
131CLK10.41456508
132CSNK1G30.41226042
133MAPK10.40419784
134ATR0.39894622
135CAMK1D0.39870865
136RPS6KL10.39476523
137RPS6KC10.39476523
138SIK30.38942054
139MAP3K60.37796181
140IRAK40.35942631
141MAPK70.35391368

Predicted pathways (KEGG)

RankGene SetZ-score
1Small cell lung cancer_Homo sapiens_hsa052222.13995192
2Adherens junction_Homo sapiens_hsa045202.02342868
3MicroRNAs in cancer_Homo sapiens_hsa052061.99606076
4Hippo signaling pathway_Homo sapiens_hsa043901.82099647
5TGF-beta signaling pathway_Homo sapiens_hsa043501.77963346
6Proteoglycans in cancer_Homo sapiens_hsa052051.74159943
7Chronic myeloid leukemia_Homo sapiens_hsa052201.74088775
8Cell cycle_Homo sapiens_hsa041101.72939883
9Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.71250684
10ECM-receptor interaction_Homo sapiens_hsa045121.71065654
11Focal adhesion_Homo sapiens_hsa045101.61204852
12Colorectal cancer_Homo sapiens_hsa052101.56882897
13Viral carcinogenesis_Homo sapiens_hsa052031.50139959
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47782994
15Pancreatic cancer_Homo sapiens_hsa052121.42812143
16Toxoplasmosis_Homo sapiens_hsa051451.42374569
17Prostate cancer_Homo sapiens_hsa052151.41469923
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.40673916
19Basal cell carcinoma_Homo sapiens_hsa052171.39367559
20p53 signaling pathway_Homo sapiens_hsa041151.36940841
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.36848203
22Renal cell carcinoma_Homo sapiens_hsa052111.35891003
23Viral myocarditis_Homo sapiens_hsa054161.35745973
24RNA transport_Homo sapiens_hsa030131.35049335
25Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.34823669
26Non-homologous end-joining_Homo sapiens_hsa034501.33393461
27Tight junction_Homo sapiens_hsa045301.31676938
28Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30500641
29Amoebiasis_Homo sapiens_hsa051461.29963258
30HTLV-I infection_Homo sapiens_hsa051661.26560398
31TNF signaling pathway_Homo sapiens_hsa046681.26508128
32mRNA surveillance pathway_Homo sapiens_hsa030151.26101120
33NF-kappa B signaling pathway_Homo sapiens_hsa040641.25634102
34Hedgehog signaling pathway_Homo sapiens_hsa043401.21021677
35mTOR signaling pathway_Homo sapiens_hsa041501.19903709
36Legionellosis_Homo sapiens_hsa051341.19645751
37Leishmaniasis_Homo sapiens_hsa051401.19551732
38Hepatitis B_Homo sapiens_hsa051611.16831897
39Endometrial cancer_Homo sapiens_hsa052131.16230433
40Dorso-ventral axis formation_Homo sapiens_hsa043201.15913667
41Shigellosis_Homo sapiens_hsa051311.14142452
42DNA replication_Homo sapiens_hsa030301.12627353
43Pathways in cancer_Homo sapiens_hsa052001.11011761
44Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10076621
45Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09431080
46Inositol phosphate metabolism_Homo sapiens_hsa005621.08871826
47Systemic lupus erythematosus_Homo sapiens_hsa053221.08375152
48Apoptosis_Homo sapiens_hsa042101.08103396
49Osteoclast differentiation_Homo sapiens_hsa043801.07755254
50Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.05037237
51Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04342160
52Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04047153
53Lysine degradation_Homo sapiens_hsa003101.02270466
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.01476546
55Malaria_Homo sapiens_hsa051441.00512619
56Herpes simplex infection_Homo sapiens_hsa051680.99981998
57Choline metabolism in cancer_Homo sapiens_hsa052310.99936034
58Bladder cancer_Homo sapiens_hsa052190.96540968
59VEGF signaling pathway_Homo sapiens_hsa043700.96462852
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.95596370
61PI3K-Akt signaling pathway_Homo sapiens_hsa041510.94615853
62B cell receptor signaling pathway_Homo sapiens_hsa046620.93464485
63Glioma_Homo sapiens_hsa052140.92884401
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92514187
65T cell receptor signaling pathway_Homo sapiens_hsa046600.91930389
66Salmonella infection_Homo sapiens_hsa051320.91626372
67Notch signaling pathway_Homo sapiens_hsa043300.91034521
68Antigen processing and presentation_Homo sapiens_hsa046120.90838812
69Wnt signaling pathway_Homo sapiens_hsa043100.90207274
70Thyroid cancer_Homo sapiens_hsa052160.89087747
71Neurotrophin signaling pathway_Homo sapiens_hsa047220.88622871
72Non-small cell lung cancer_Homo sapiens_hsa052230.87903523
73Measles_Homo sapiens_hsa051620.87655565
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84883084
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.84624701
76Spliceosome_Homo sapiens_hsa030400.83836472
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83801547
78Oocyte meiosis_Homo sapiens_hsa041140.82928319
79Epstein-Barr virus infection_Homo sapiens_hsa051690.82753433
80Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.82700267
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82487000
82Phospholipase D signaling pathway_Homo sapiens_hsa040720.80627974
83Prolactin signaling pathway_Homo sapiens_hsa049170.79993326
84Melanoma_Homo sapiens_hsa052180.79673296
85FoxO signaling pathway_Homo sapiens_hsa040680.78908344
86Rap1 signaling pathway_Homo sapiens_hsa040150.78841282
87Platelet activation_Homo sapiens_hsa046110.78778902
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.73262540
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73253781
90Acute myeloid leukemia_Homo sapiens_hsa052210.72821580
91Long-term potentiation_Homo sapiens_hsa047200.72414611
92Toll-like receptor signaling pathway_Homo sapiens_hsa046200.71958282
93Influenza A_Homo sapiens_hsa051640.71936587
94Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.71761345
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.71636759
96ErbB signaling pathway_Homo sapiens_hsa040120.71544289
97Alcoholism_Homo sapiens_hsa050340.70658829
98Melanogenesis_Homo sapiens_hsa049160.70067486
99Hepatitis C_Homo sapiens_hsa051600.69867835
100Basal transcription factors_Homo sapiens_hsa030220.69330511
101Chemokine signaling pathway_Homo sapiens_hsa040620.68960340
102MAPK signaling pathway_Homo sapiens_hsa040100.67935269
103Insulin signaling pathway_Homo sapiens_hsa049100.67698446
104Pertussis_Homo sapiens_hsa051330.66308305
105Axon guidance_Homo sapiens_hsa043600.66148467
106Endocytosis_Homo sapiens_hsa041440.66117999
107Sphingolipid signaling pathway_Homo sapiens_hsa040710.65766245
108Tuberculosis_Homo sapiens_hsa051520.62513325
109Nucleotide excision repair_Homo sapiens_hsa034200.62300468
110Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60166398
111Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59822624
112HIF-1 signaling pathway_Homo sapiens_hsa040660.59388283
113Estrogen signaling pathway_Homo sapiens_hsa049150.57980529
114RNA degradation_Homo sapiens_hsa030180.57864103
115GnRH signaling pathway_Homo sapiens_hsa049120.55818496
116Gap junction_Homo sapiens_hsa045400.55260222
117Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.55092455
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54168124
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52983202
120Mismatch repair_Homo sapiens_hsa034300.52900683

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