MEX3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.74070648
2fusion of sperm to egg plasma membrane (GO:0007342)9.09371441
3acrosome reaction (GO:0007340)8.73162097
4cell wall macromolecule catabolic process (GO:0016998)8.41642336
5cell wall macromolecule metabolic process (GO:0044036)8.41642336
6sperm-egg recognition (GO:0035036)8.28739933
7acrosome assembly (GO:0001675)7.98620639
8binding of sperm to zona pellucida (GO:0007339)7.70648848
9cell-cell recognition (GO:0009988)7.30586559
10spermatid development (GO:0007286)7.16161561
11epithelial cilium movement (GO:0003351)7.15907896
12axonemal dynein complex assembly (GO:0070286)6.99233578
13multicellular organism reproduction (GO:0032504)6.96629218
14plasma membrane fusion (GO:0045026)6.79652855
15motile cilium assembly (GO:0044458)6.72941563
16regulation of cilium movement (GO:0003352)6.48087496
17reproduction (GO:0000003)6.10412433
18cilium or flagellum-dependent cell motility (GO:0001539)5.88619437
19cilium movement (GO:0003341)5.86562372
20synaptonemal complex organization (GO:0070193)5.73858016
21synaptonemal complex assembly (GO:0007130)5.73727332
22microtubule depolymerization (GO:0007019)5.54513832
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.41397019
24piRNA metabolic process (GO:0034587)5.19277887
25spermatogenesis (GO:0007283)5.13353964
26male gamete generation (GO:0048232)5.11399926
27male meiosis (GO:0007140)5.08030583
28single fertilization (GO:0007338)4.86111331
29negative regulation of inclusion body assembly (GO:0090084)4.85929269
30sperm capacitation (GO:0048240)4.83754467
31chromosome condensation (GO:0030261)4.78334490
32gamete generation (GO:0007276)4.70618436
33ventricular system development (GO:0021591)4.53837221
34microtubule severing (GO:0051013)4.48190439
35DNA packaging (GO:0006323)4.46641187
36fertilization (GO:0009566)4.43602587
37germ cell development (GO:0007281)4.33994380
38regulation of microtubule-based movement (GO:0060632)4.32384512
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.28354925
40regulation of inclusion body assembly (GO:0090083)4.23670871
41paraxial mesoderm development (GO:0048339)4.22536706
42left/right pattern formation (GO:0060972)4.17943330
43organic cation transport (GO:0015695)3.98539864
44cell recognition (GO:0008037)3.95616653
45spermatid nucleus differentiation (GO:0007289)3.78485980
46multicellular organismal reproductive process (GO:0048609)3.70942421
47heterochromatin organization (GO:0070828)3.69677674
48seminiferous tubule development (GO:0072520)3.67878778
49chromosome organization involved in meiosis (GO:0070192)3.64032373
50convergent extension (GO:0060026)3.61382629
51protein-DNA complex disassembly (GO:0032986)3.61197462
52nucleosome disassembly (GO:0006337)3.61197462
53chaperone-mediated protein complex assembly (GO:0051131)3.57438148
54notochord development (GO:0030903)3.53117372
55calcium ion-dependent exocytosis (GO:0017156)3.47383218
56genitalia morphogenesis (GO:0035112)3.43489054
57male meiosis I (GO:0007141)3.43265132
58cochlea morphogenesis (GO:0090103)3.33508824
59mitotic sister chromatid cohesion (GO:0007064)3.31662594
60DNA methylation involved in gamete generation (GO:0043046)3.27154831
61meiotic nuclear division (GO:0007126)3.20414094
62multicellular organismal development (GO:0007275)3.18753520
63nuclear pore complex assembly (GO:0051292)3.17051019
64establishment of apical/basal cell polarity (GO:0035089)3.16075447
65protein polyglutamylation (GO:0018095)3.15983434
66Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.15948975
67sexual reproduction (GO:0019953)3.08653683
68regulation of establishment of planar polarity (GO:0090175)3.00193899
69embryonic foregut morphogenesis (GO:0048617)2.99595085
70chromatin silencing (GO:0006342)2.98368100
71establishment of tissue polarity (GO:0007164)2.97818772
72establishment of planar polarity (GO:0001736)2.97818772
73pattern specification involved in kidney development (GO:0061004)2.94807978
74establishment or maintenance of monopolar cell polarity (GO:0061339)2.94291672
75establishment of monopolar cell polarity (GO:0061162)2.94291672
76gene silencing by RNA (GO:0031047)2.93961945
77single strand break repair (GO:0000012)2.93896394
78lung-associated mesenchyme development (GO:0060484)2.93807003
79artery development (GO:0060840)2.92434651
80glycerol ether metabolic process (GO:0006662)2.92013429
81non-canonical Wnt signaling pathway (GO:0035567)2.88728126
82regulation of spindle checkpoint (GO:0090231)2.84446427
83gene silencing (GO:0016458)2.83343419
84outer ear morphogenesis (GO:0042473)2.83001080
85negative regulation of chondrocyte differentiation (GO:0032331)2.81570934
86dorsal/ventral axis specification (GO:0009950)2.81468482
87microtubule polymerization or depolymerization (GO:0031109)2.80284623
88DNA replication-dependent nucleosome organization (GO:0034723)2.79703876
89DNA replication-dependent nucleosome assembly (GO:0006335)2.79703876
90negative regulation of organelle assembly (GO:1902116)2.79041073
91sequestering of actin monomers (GO:0042989)2.78905391
92positive regulation of macrophage activation (GO:0043032)2.78171167
93regulation of cell fate specification (GO:0042659)2.77153382
94establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.76909283
95interferon-gamma secretion (GO:0072643)2.75932685
96regulation of RNA export from nucleus (GO:0046831)2.75721457
97nucleus organization (GO:0006997)2.75690739
98meiosis I (GO:0007127)2.75424707
99polarized epithelial cell differentiation (GO:0030859)2.75091493
100protein localization to chromosome, centromeric region (GO:0071459)2.74825529
101establishment or maintenance of bipolar cell polarity (GO:0061245)2.73358226
102establishment or maintenance of apical/basal cell polarity (GO:0035088)2.73358226
103branching involved in salivary gland morphogenesis (GO:0060445)2.71229842
104nuclear pore organization (GO:0006999)2.70813282
105G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.69275236
106dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.67553221
107ether metabolic process (GO:0018904)2.67186928
108regulation of NFAT protein import into nucleus (GO:0051532)2.64188255
109negative regulation of cell fate specification (GO:0009996)2.60909333
110regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.60716325
111regulation of hippo signaling (GO:0035330)2.60686270
112monoubiquitinated protein deubiquitination (GO:0035520)2.59619595
113meiotic cell cycle (GO:0051321)2.59146099
114protein complex localization (GO:0031503)2.59094016
115hippo signaling (GO:0035329)2.58324566
116negative regulation of embryonic development (GO:0045992)2.57757244
117peptidyl-lysine dimethylation (GO:0018027)2.57242723
118embryonic camera-type eye morphogenesis (GO:0048596)2.55503236
119limb bud formation (GO:0060174)2.54936606
120chromatin assembly (GO:0031497)2.54704522
121pre-miRNA processing (GO:0031054)2.51083033
122planar cell polarity pathway involved in neural tube closure (GO:0090179)2.50210311
123negative regulation of catenin import into nucleus (GO:0035414)2.50196018
124regulation of histone H3-K9 methylation (GO:0051570)2.49836837
125hindbrain development (GO:0030902)2.49494766
126positive regulation of gastrulation (GO:2000543)2.48991116
127negative regulation of gene expression, epigenetic (GO:0045814)2.48579357
128myoblast fusion (GO:0007520)2.47606029
129desmosome organization (GO:0002934)2.45937632
130glomerular visceral epithelial cell development (GO:0072015)2.45257034
131NLS-bearing protein import into nucleus (GO:0006607)2.44596959
132regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.44596601
133mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.43718047
134embryonic skeletal joint morphogenesis (GO:0060272)2.42756667
135regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.42657452
136kidney mesenchyme development (GO:0072074)2.41849072
137regulation of cardioblast differentiation (GO:0051890)2.41154585
138negative regulation of DNA repair (GO:0045738)2.40314449
139negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39178865
140lateral sprouting from an epithelium (GO:0060601)2.34243502
141cell migration involved in sprouting angiogenesis (GO:0002042)2.33968733
142outflow tract septum morphogenesis (GO:0003148)2.31466446
143negative regulation of cartilage development (GO:0061037)2.30868577
144mesenchyme morphogenesis (GO:0072132)2.30538119
145cranial nerve morphogenesis (GO:0021602)2.28073222
146regulation of catenin import into nucleus (GO:0035412)2.27622438
147tooth mineralization (GO:0034505)2.26992367
148regulation of heart morphogenesis (GO:2000826)2.26647429
149cell proliferation involved in metanephros development (GO:0072203)2.25398160
150regulation of mesenchymal cell apoptotic process (GO:2001053)2.24663531
151embryonic eye morphogenesis (GO:0048048)2.23344230
152epithelial cell-cell adhesion (GO:0090136)2.23134364
153cell-cell junction maintenance (GO:0045217)2.22561339
154glomerular epithelial cell development (GO:0072310)2.19005555
155atrioventricular valve morphogenesis (GO:0003181)2.18596285
156regulation of centriole replication (GO:0046599)2.18407278
157mesenchymal to epithelial transition (GO:0060231)2.16945739
158regulation of stem cell maintenance (GO:2000036)2.15366050
159renal system development (GO:0072001)2.14951386
160endocardial cushion morphogenesis (GO:0003203)2.12902414
161lymphangiogenesis (GO:0001946)2.12901555
162cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.12869368
163regulation of transcription involved in cell fate commitment (GO:0060850)2.12740056
164mitotic metaphase plate congression (GO:0007080)2.11281185
165rRNA methylation (GO:0031167)2.10516097
166axon extension involved in axon guidance (GO:0048846)2.10158346
167neuron projection extension involved in neuron projection guidance (GO:1902284)2.10158346
168lymph vessel development (GO:0001945)2.09987397
169positive regulation of mesenchymal cell proliferation (GO:0002053)2.09850203
170regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.08864709
171neural tube closure (GO:0001843)2.08776108
172urogenital system development (GO:0001655)2.08323501
173regulation of cardioblast proliferation (GO:0003264)2.07257124
174regulation of secondary heart field cardioblast proliferation (GO:0003266)2.07257124
175tube closure (GO:0060606)2.06930537
176endothelial cell morphogenesis (GO:0001886)2.06163727
177semaphorin-plexin signaling pathway (GO:0071526)2.04948419
178cell proliferation involved in kidney development (GO:0072111)2.04663017

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.58890297
2STAT6_21828071_ChIP-Seq_BEAS2B_Human5.33552440
3EZH2_22144423_ChIP-Seq_EOC_Human3.62115714
4FOXM1_23109430_ChIP-Seq_U2OS_Human2.55939929
5* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.55429832
6TP63_19390658_ChIP-ChIP_HaCaT_Human2.51534966
7GATA1_26923725_Chip-Seq_HPCs_Mouse2.31269261
8GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.29924835
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.16498954
10ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.09850688
11ZNF274_21170338_ChIP-Seq_K562_Hela2.03272333
12BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.02892858
13EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.02451718
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97467392
15EED_16625203_ChIP-ChIP_MESCs_Mouse1.90573221
16EZH2_27304074_Chip-Seq_ESCs_Mouse1.88045726
17PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.81037086
18DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.79977594
19TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79393317
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.78898998
21SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.78285063
22ERG_21242973_ChIP-ChIP_JURKAT_Human1.73462418
23NFIB_24661679_ChIP-Seq_LUNG_Mouse1.73017660
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.70376093
25* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.69147025
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.62830513
27EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62336092
28RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62336092
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.60654658
30TP53_20018659_ChIP-ChIP_R1E_Mouse1.59804192
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.57980256
32E2F7_22180533_ChIP-Seq_HELA_Human1.55591026
33RBPJ_22232070_ChIP-Seq_NCS_Mouse1.54725260
34* ELK4_26923725_Chip-Seq_MESODERM_Mouse1.52983911
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.50433120
36* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.47370372
37ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.46682535
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46415269
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46182054
40AR_21909140_ChIP-Seq_LNCAP_Human1.45586522
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.45409348
42* FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44605756
43TP53_22127205_ChIP-Seq_IMR90_Human1.44396133
44KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.42251944
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.40904490
46ZNF263_19887448_ChIP-Seq_K562_Human1.39746041
47FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39440978
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.36283732
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35271936
50RACK7_27058665_Chip-Seq_MCF-7_Human1.33440783
51RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33092410
52NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.30949254
53WDR5_24793694_ChIP-Seq_LNCAP_Human1.30890449
54SOX2_16153702_ChIP-ChIP_HESCs_Human1.30684692
55SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.30501244
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.28586120
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.28556208
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27871575
59SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25203248
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.24595413
61KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.24500647
62TCF7_22412390_ChIP-Seq_EML_Mouse1.24082828
63* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23814563
64MYC_18555785_ChIP-Seq_MESCs_Mouse1.22625741
65KDM2B_26808549_Chip-Seq_DND41_Human1.21765499
66POU5F1_16153702_ChIP-ChIP_HESCs_Human1.20709497
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.20631542
68NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.20110975
69* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19057256
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18631544
71MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.18412460
72JARID2_20064375_ChIP-Seq_MESCs_Mouse1.15971510
73CBX2_27304074_Chip-Seq_ESCs_Mouse1.15929084
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.15677731
75CTCF_27219007_Chip-Seq_Bcells_Human1.13856393
76SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12884179
77* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.12025934
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10897211
79TET1_21451524_ChIP-Seq_MESCs_Mouse1.10843431
80VDR_22108803_ChIP-Seq_LS180_Human1.10298406
81* GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.09941261
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.08663263
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.07653072
84PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.07046878
85YY1_22570637_ChIP-Seq_MALME-3M_Human1.06064694
86CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06022548
87SALL1_21062744_ChIP-ChIP_HESCs_Human1.05243462
88TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05156536
89* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05120075
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.04661032
91NANOG_21062744_ChIP-ChIP_HESCs_Human1.03211113
92PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.02699442
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02032868
94PKCTHETA_26484144_Chip-Seq_BREAST_Human1.01631654
95MYC_19079543_ChIP-ChIP_MESCs_Mouse1.01388417
96SMC3_22415368_ChIP-Seq_MEFs_Mouse1.01014116
97LXR_22292898_ChIP-Seq_THP-1_Human1.00695746
98SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00610830
99RUNX1_27514584_Chip-Seq_MCF-7_Human1.00560720
100TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.00439507
101RING1B_27294783_Chip-Seq_ESCs_Mouse1.00069830
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99756753
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99756753
104* ELF1_20517297_ChIP-Seq_JURKAT_Human0.99473661
105POU5F1_16518401_ChIP-PET_MESCs_Mouse0.98395155
106SOX3_22085726_ChIP-Seq_NPCs_Mouse0.97648448
107* KDM2B_26808549_Chip-Seq_K562_Human0.97066212
108DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96960218
109SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.96060988
110NANOG_16153702_ChIP-ChIP_HESCs_Human0.95663308
111TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95385019
112TCF3_18692474_ChIP-Seq_MESCs_Mouse0.95319852
113TP53_23651856_ChIP-Seq_MEFs_Mouse0.95287981
114P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95054999
115* SUZ12_27294783_Chip-Seq_ESCs_Mouse0.95023518
116EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94963717
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.94891251
118SRY_22984422_ChIP-ChIP_TESTIS_Rat0.94432110
119UBF1/2_26484160_Chip-Seq_HMECs_Human0.94309560
120SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.94302273
121ARNT_22903824_ChIP-Seq_MCF-7_Human0.93855059
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93782210
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.93454919
124KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.93347270
125TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93284195
126* MYC_27129775_Chip-Seq_CORNEA_Mouse0.92871286
127ISL1_27105846_Chip-Seq_CPCs_Mouse0.92840447
128REST_21632747_ChIP-Seq_MESCs_Mouse0.92654079
129* CTCF_20526341_ChIP-Seq_ESCs_Human0.91900372
130SMAD3_21741376_ChIP-Seq_ESCs_Human0.91500039
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.90243215
132SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.90178354
133TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89804205
134KLF5_25053715_ChIP-Seq_YYC3_Human0.89340192
135KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.88965020
136KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.88965020
137KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.88965020
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88513263
139RNF2_27304074_Chip-Seq_NSC_Mouse0.88403610
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.87984995
141EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87962232
142* LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.87782847
143HIF1A_21447827_ChIP-Seq_MCF-7_Human0.87496819
144* SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.87451631
145* OCT4_19829295_ChIP-Seq_ESCs_Human0.86900781
146SMC4_20622854_ChIP-Seq_HELA_Human0.86621156
147ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.86292008
148TP63_22573176_ChIP-Seq_HFKS_Human0.86262860
149RING1B_27294783_Chip-Seq_NPCs_Mouse0.85930222
150JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.85846745
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.85344094
152* SOX11_22085726_ChIP-Seq_ESNs_Mouse0.85281002
153SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84799514
154* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.84692625
155NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.83974117
156TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.83863260
157TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83230827
158EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.80818459
159CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80494707
160* KLF4_19829295_ChIP-Seq_ESCs_Human0.80389922
161CBP_20019798_ChIP-Seq_JUKART_Human0.80250963
162IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.80250963
163KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79656256

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive3.84435910
2MP0001929_abnormal_gametogenesis3.45335177
3MP0005623_abnormal_meninges_morphology3.27589321
4MP0002653_abnormal_ependyma_morphology2.88785727
5MP0000566_synostosis2.53052487
6MP0008877_abnormal_DNA_methylation2.51935274
7MP0006292_abnormal_olfactory_placode2.46068576
8MP0002210_abnormal_sex_determination2.31045894
9MP0010234_abnormal_vibrissa_follicle2.24169798
10MP0010030_abnormal_orbit_morphology2.23874429
11MP0002161_abnormal_fertility/fecundity2.16789881
12MP0003705_abnormal_hypodermis_morpholog2.08048793
13MP0008438_abnormal_cutaneous_collagen2.03872872
14MP0001145_abnormal_male_reproductive2.01999182
15MP0005410_abnormal_fertilization10.1538937
16MP0003941_abnormal_skin_development1.94485455
17MP0004233_abnormal_muscle_weight1.92178894
18MP0002282_abnormal_trachea_morphology1.87780186
19MP0000537_abnormal_urethra_morphology1.87698285
20MP0003115_abnormal_respiratory_system1.70273173
21MP0000653_abnormal_sex_gland1.67338639
22MP0003942_abnormal_urinary_system1.63131055
23MP0000534_abnormal_ureter_morphology1.59452062
24MP0003385_abnormal_body_wall1.53395232
25MP0000762_abnormal_tongue_morphology1.52085329
26MP0005076_abnormal_cell_differentiation1.51018463
27MP0002938_white_spotting1.44371490
28MP0005670_abnormal_white_adipose1.41923184
29MP0000733_abnormal_muscle_development1.40229768
30MP0001293_anophthalmia1.39632606
31MP0002254_reproductive_system_inflammat1.37350819
32MP0003119_abnormal_digestive_system1.36988661
33MP0000049_abnormal_middle_ear1.36925531
34MP0002234_abnormal_pharynx_morphology1.33685202
35MP0003861_abnormal_nervous_system1.32981397
36MP0002084_abnormal_developmental_patter1.31438779
37MP0009053_abnormal_anal_canal1.29908627
38MP0005503_abnormal_tendon_morphology1.28348284
39MP0000678_abnormal_parathyroid_gland1.25920961
40MP0002160_abnormal_reproductive_system1.22389252
41MP0003283_abnormal_digestive_organ1.22290469
42MP0002085_abnormal_embryonic_tissue1.21146237
43MP0004133_heterotaxia1.19179286
44MP0004272_abnormal_basement_membrane1.18199507
45MP0004197_abnormal_fetal_growth/weight/1.17690420
46MP0009379_abnormal_foot_pigmentation1.16407152
47MP0001348_abnormal_lacrimal_gland1.15397519
48MP0002697_abnormal_eye_size1.15222134
49MP0003938_abnormal_ear_development1.14467932
50MP0002092_abnormal_eye_morphology1.13580334
51MP0005394_taste/olfaction_phenotype1.13137293
52MP0005499_abnormal_olfactory_system1.13137293
53MP0000569_abnormal_digit_pigmentation1.12908881
54MP0001849_ear_inflammation1.12551239
55MP0009278_abnormal_bone_marrow1.12332802
56MP0002098_abnormal_vibrissa_morphology1.12241952
57MP0001730_embryonic_growth_arrest1.10926727
58MP0009250_abnormal_appendicular_skeleto1.10507779
59MP0003755_abnormal_palate_morphology1.10452583
60MP0010352_gastrointestinal_tract_polyps1.10399678
61MP0002249_abnormal_larynx_morphology1.10321774
62MP0002116_abnormal_craniofacial_bone1.08969527
63MP0005257_abnormal_intraocular_pressure1.07970586
64MP0002932_abnormal_joint_morphology1.07684601
65MP0000579_abnormal_nail_morphology1.06611045
66MP0003935_abnormal_craniofacial_develop1.06206950
67MP0000778_abnormal_nervous_system1.05081631
68MP0000613_abnormal_salivary_gland1.03726752
69MP0005275_abnormal_skin_tensile1.03323292
70MP0003279_aneurysm1.02575577
71MP0003937_abnormal_limbs/digits/tail_de1.02119994
72MP0003111_abnormal_nucleus_morphology1.01671951
73MP0000428_abnormal_craniofacial_morphol1.00898223
74MP0000467_abnormal_esophagus_morphology0.98825847
75MP0000432_abnormal_head_morphology0.97323307
76MP0001879_abnormal_lymphatic_vessel0.96835104
77MP0002089_abnormal_postnatal_growth/wei0.96743718
78MP0001697_abnormal_embryo_size0.95922599
79MP0005380_embryogenesis_phenotype0.95909146
80MP0001672_abnormal_embryogenesis/_devel0.95909146
81MP0003693_abnormal_embryo_hatching0.93468617
82MP0002796_impaired_skin_barrier0.91705944
83MP0001346_abnormal_lacrimal_gland0.90623182
84MP0003890_abnormal_embryonic-extraembry0.90112612
85MP0002751_abnormal_autonomic_nervous0.87734157
86MP0009384_cardiac_valve_regurgitation0.86461156
87MP0003091_abnormal_cell_migration0.86234606
88MP0003121_genomic_imprinting0.85321905
89MP0002233_abnormal_nose_morphology0.84995533
90MP0002088_abnormal_embryonic_growth/wei0.84129072
91MP0003984_embryonic_growth_retardation0.84045360
92MP0001299_abnormal_eye_distance/0.83062549
93MP0003718_maternal_effect0.82631254
94MP0002152_abnormal_brain_morphology0.80631918
95MP0002114_abnormal_axial_skeleton0.80486140
96MP0005367_renal/urinary_system_phenotyp0.80395876
97MP0000516_abnormal_urinary_system0.80395876
98MP0000767_abnormal_smooth_muscle0.80272619
99MP0003123_paternal_imprinting0.79926840
100MP0002184_abnormal_innervation0.79803321
101MP0000026_abnormal_inner_ear0.78775398
102MP0003566_abnormal_cell_adhesion0.78630101
103MP0000350_abnormal_cell_proliferation0.77988510
104MP0005508_abnormal_skeleton_morphology0.77446693
105MP0003878_abnormal_ear_physiology0.77223419
106MP0005377_hearing/vestibular/ear_phenot0.77223419
107MP0005197_abnormal_uvea_morphology0.76739676
108MP0002081_perinatal_lethality0.76565490
109MP0001188_hyperpigmentation0.75727314
110MP0003122_maternal_imprinting0.75552823
111MP0004858_abnormal_nervous_system0.75542696
112MP0002925_abnormal_cardiovascular_devel0.75074249
113MP0008789_abnormal_olfactory_epithelium0.74937157
114MP0000462_abnormal_digestive_system0.74886267
115MP0002080_prenatal_lethality0.74212613
116MP0001340_abnormal_eyelid_morphology0.74013063
117MP0008932_abnormal_embryonic_tissue0.73676321
118MP0002086_abnormal_extraembryonic_tissu0.73012955
119MP0003077_abnormal_cell_cycle0.72968661
120MP0004134_abnormal_chest_morphology0.69700100
121MP0009703_decreased_birth_body0.68830505
122MP0002111_abnormal_tail_morphology0.68828731
123MP0005248_abnormal_Harderian_gland0.68458196
124MP0009672_abnormal_birth_weight0.67915056
125MP0005391_vision/eye_phenotype0.67807893
126MP0008007_abnormal_cellular_replicative0.67578946
127MP0008770_decreased_survivor_rate0.67497133
128MP0001286_abnormal_eye_development0.67383340
129MP0004811_abnormal_neuron_physiology0.66541950
130MP0008995_early_reproductive_senescence0.66485062
131MP0004957_abnormal_blastocyst_morpholog0.66241315
132MP0002109_abnormal_limb_morphology0.64042247

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)8.42767814
2Dynein arm defect of respiratory motile cilia (HP:0012255)8.40107617
3Absent/shortened dynein arms (HP:0200106)8.40107617
4Abnormal respiratory epithelium morphology (HP:0012253)5.82348386
5Abnormal respiratory motile cilium morphology (HP:0005938)5.82348386
6Abnormal respiratory motile cilium physiology (HP:0012261)5.75677068
7Infertility (HP:0000789)4.71526018
8Chronic bronchitis (HP:0004469)4.68157684
9Rhinitis (HP:0012384)4.59593535
10Abnormal ciliary motility (HP:0012262)4.23663197
11Male infertility (HP:0003251)4.03736907
12Nasal polyposis (HP:0100582)3.94398951
13Short 4th metacarpal (HP:0010044)3.19537081
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.19537081
15Abnormality of the nasal mucosa (HP:0000433)3.11499581
16Nephronophthisis (HP:0000090)2.90935098
17Abnormality of dentin (HP:0010299)2.76135675
18Protrusio acetabuli (HP:0003179)2.75352666
19Heterotopia (HP:0002282)2.68316875
20Abnormality of the aortic arch (HP:0012303)2.62152836
21Shallow orbits (HP:0000586)2.61151180
22Bronchitis (HP:0012387)2.55526314
23Bronchiectasis (HP:0002110)2.46748675
24Abnormality of the 4th metacarpal (HP:0010012)2.41077139
25Premature rupture of membranes (HP:0001788)2.39477859
26Neonatal short-limb short stature (HP:0008921)2.36786836
27Impulsivity (HP:0100710)2.36251800
28Buphthalmos (HP:0000557)2.31217013
29Tubular atrophy (HP:0000092)2.28378099
30Bilateral microphthalmos (HP:0007633)2.28009781
31Abnormality of the lower motor neuron (HP:0002366)2.26108993
32Septo-optic dysplasia (HP:0100842)2.21288199
33Maternal diabetes (HP:0009800)2.19867966
34Abnormal number of incisors (HP:0011064)2.16972302
35Renal duplication (HP:0000075)2.14488793
36Partial duplication of the phalanx of hand (HP:0009999)2.10465332
37Bladder diverticulum (HP:0000015)2.09915476
38Turricephaly (HP:0000262)2.09171401
39Aplasia/Hypoplasia of the sacrum (HP:0008517)2.04087682
40Renovascular hypertension (HP:0100817)2.03105611
41Abnormality of the renal medulla (HP:0100957)2.03029226
42Anophthalmia (HP:0000528)2.02154325
43Hyperacusis (HP:0010780)1.99774564
44Aplasia involving bones of the upper limbs (HP:0009823)1.98809438
45Aplasia of the phalanges of the hand (HP:0009802)1.98809438
46Aplasia involving bones of the extremities (HP:0009825)1.98809438
47Neoplasm of the heart (HP:0100544)1.96860643
48Esophageal atresia (HP:0002032)1.96677573
49Choroideremia (HP:0001139)1.95244314
50Optic nerve hypoplasia (HP:0000609)1.94574578
51Cerebral aneurysm (HP:0004944)1.93072041
52Progressive sensorineural hearing impairment (HP:0000408)1.91544069
53Down-sloping shoulders (HP:0200021)1.91010953
54Bell-shaped thorax (HP:0001591)1.90826468
55Shawl scrotum (HP:0000049)1.90044361
56Partial duplication of thumb phalanx (HP:0009944)1.89925038
57High anterior hairline (HP:0009890)1.89297325
58Hand muscle atrophy (HP:0009130)1.88598198
59Morphological abnormality of the middle ear (HP:0008609)1.88428838
60Short humerus (HP:0005792)1.87609658
61Recurrent otitis media (HP:0000403)1.87604598
62Difficulty climbing stairs (HP:0003551)1.87495731
63Amyotrophic lateral sclerosis (HP:0007354)1.86695681
64Short ribs (HP:0000773)1.85237066
65Ankle contracture (HP:0006466)1.84512257
66Distal upper limb amyotrophy (HP:0007149)1.83535203
67Upper limb amyotrophy (HP:0009129)1.83535203
68Double outlet right ventricle (HP:0001719)1.83325216
69Congenital malformation of the right heart (HP:0011723)1.83325216
70Bowel diverticulosis (HP:0005222)1.82463070
71Genu recurvatum (HP:0002816)1.81858552
72Abnormal spermatogenesis (HP:0008669)1.81820490
73Arnold-Chiari malformation (HP:0002308)1.79385741
74Broad distal phalanx of finger (HP:0009836)1.78800619
75Pterygium (HP:0001059)1.78313187
76Soft skin (HP:0000977)1.77965450
77Wrist flexion contracture (HP:0001239)1.77362148
78Absent epiphyses (HP:0010577)1.75949484
79Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.75949484
80Hallux valgus (HP:0001822)1.74556360
81Thin ribs (HP:0000883)1.74282758
82Bronchomalacia (HP:0002780)1.73513831
83Enlarged penis (HP:0000040)1.73508139
84Preaxial foot polydactyly (HP:0001841)1.73163267
85Deviation of the hallux (HP:0010051)1.73119135
86Vertebral clefting (HP:0008428)1.70770584
87Aplasia/hypoplasia of the humerus (HP:0006507)1.69973253
88Overriding aorta (HP:0002623)1.69388239
89Asymmetry of the thorax (HP:0001555)1.67982936
90Abnormality of the lacrimal duct (HP:0011481)1.67812085
91Glossoptosis (HP:0000162)1.66822029
92Bicornuate uterus (HP:0000813)1.66161002
93Broad metatarsal (HP:0001783)1.65171952
94Astrocytoma (HP:0009592)1.65161278
95Abnormality of the astrocytes (HP:0100707)1.65161278
96Achilles tendon contracture (HP:0001771)1.63173068
97Skull defect (HP:0001362)1.63097841
98Unilateral renal agenesis (HP:0000122)1.62420257
99Selective tooth agenesis (HP:0001592)1.62326867
100Renal dysplasia (HP:0000110)1.62029862
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.61665528
102Abnormality of the nasolacrimal system (HP:0000614)1.60587236
103Cerebral inclusion bodies (HP:0100314)1.58903053
104Abnormality of abdominal situs (HP:0011620)1.58544715
105Abdominal situs inversus (HP:0003363)1.58544715
106Congenital glaucoma (HP:0001087)1.58177983
107Lymphangioma (HP:0100764)1.57962532
108Myelomeningocele (HP:0002475)1.57801327
109Flat cornea (HP:0007720)1.54428683
110Gastrointestinal atresia (HP:0002589)1.52783505
111Atresia of the external auditory canal (HP:0000413)1.52691423
112Broad face (HP:0000283)1.52290709
113Microglossia (HP:0000171)1.51341039
114Disproportionate tall stature (HP:0001519)1.51317649
115Omphalocele (HP:0001539)1.50716064
116Choanal stenosis (HP:0000452)1.50513811
117Cutaneous finger syndactyly (HP:0010554)1.50447708
118Elfin facies (HP:0004428)1.50265538
119Hyperextensible skin (HP:0000974)1.49619692
120Pendular nystagmus (HP:0012043)1.48986546
121Coronal craniosynostosis (HP:0004440)1.48640799
122Absent septum pellucidum (HP:0001331)1.48585046
123Hemiparesis (HP:0001269)1.48465542
124Ulnar bowing (HP:0003031)1.48319326
125Midface retrusion (HP:0011800)1.48083331
126Short phalanx of the thumb (HP:0009660)1.47986607
127Abnormality of the distal phalanx of the thumb (HP:0009617)1.47616409
128Molar tooth sign on MRI (HP:0002419)1.47428184
129Abnormality of midbrain morphology (HP:0002418)1.47428184
130Megalocornea (HP:0000485)1.47417251
131Insomnia (HP:0100785)1.46157051
132Cutaneous syndactyly (HP:0012725)1.46011778
133Abnormality of the parietal bone (HP:0002696)1.45572665
134Absent frontal sinuses (HP:0002688)1.45429505
135Duplication of thumb phalanx (HP:0009942)1.45370931
136Gonadotropin excess (HP:0000837)1.44986362
137Midline defect of the nose (HP:0004122)1.44332146
138Cholecystitis (HP:0001082)1.43866100
139Abnormal gallbladder physiology (HP:0012438)1.43866100
140Increased nuchal translucency (HP:0010880)1.43251560
141Spinal rigidity (HP:0003306)1.42543780
142Stage 5 chronic kidney disease (HP:0003774)1.41934880
143Facial cleft (HP:0002006)1.41364487
144Broad thumb (HP:0011304)1.41292912
145Natal tooth (HP:0000695)1.40744651
146Patellar dislocation (HP:0002999)1.40029726
147Facial hemangioma (HP:0000329)1.39467826
148Aplasia/Hypoplasia of the brainstem (HP:0007362)1.39265853
149Hypoplasia of the brainstem (HP:0002365)1.39265853
150Short nail (HP:0001799)1.38890932
151Abnormality of the phalanges of the hallux (HP:0010057)1.38591083
152Chin dimple (HP:0010751)1.37798116
153Nasolacrimal duct obstruction (HP:0000579)1.37764009
154Difficulty running (HP:0009046)1.35381937
155Pachygyria (HP:0001302)1.34879717
156Supernumerary spleens (HP:0009799)1.34432431
157Hypoplasia of the capital femoral epiphysis (HP:0003090)1.34016973
158Atrophic scars (HP:0001075)1.33122262
159Mitral valve prolapse (HP:0001634)1.32538895
160Rhizomelia (HP:0008905)1.31183646
161Fragile skin (HP:0001030)1.31044871
162Supernumerary ribs (HP:0005815)1.30842165
163Hypoplastic labia majora (HP:0000059)1.29941317
164Abnormal ventriculo-arterial connection (HP:0011563)1.29118264
165Abnormal connection of the cardiac segments (HP:0011545)1.29118264

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK15.92337412
2ICK5.55684530
3PRKD35.06721278
4PDK44.50847212
5PDK34.50847212
6PLK43.01828547
7PDK22.82563210
8EEF2K2.43370511
9VRK22.37644717
10MAP3K102.25498290
11PNCK2.10165744
12TYRO32.09681407
13TRIB32.03383077
14MST1R2.00095643
15NEK21.99232195
16DYRK1B1.95000196
17SMG11.76642809
18PTK2B1.75158540
19TAF11.72938763
20TNIK1.71239362
21STK38L1.70171829
22CDK121.65857349
23DDR21.61800441
24MARK11.58977250
25LATS21.49055915
26STK381.46428175
27DYRK31.44290093
28IRAK31.44099022
29STK391.32635952
30BUB11.32100829
31EPHB21.26297248
32MAP3K91.21981402
33WNK41.21668377
34PDGFRA1.21279344
35LMTK21.18548140
36PAK21.16724469
37PKN21.14819890
38MTOR1.12979003
39BRD41.12398420
40INSRR1.10162431
41LATS11.08924376
42WEE11.04402937
43VRK11.00407286
44MUSK0.98413949
45TTN0.98285526
46PAK40.98067805
47TIE10.95192603
48TESK20.94645980
49BRAF0.94160097
50BMX0.92412218
51CASK0.91844216
52STK30.87834719
53DYRK20.87441802
54SRPK10.84312300
55CAMK1G0.82699981
56MKNK20.82081038
57PLK30.81461793
58TTK0.81444686
59MARK20.81235111
60RIPK10.78509444
61CDC70.78444423
62CHEK20.78320332
63PLK20.77578438
64PRKG20.76195427
65PAK60.75557741
66ERBB40.75509814
67CDK80.72652244
68PBK0.72191769
69WNK10.71824347
70PAK10.69248355
71BRSK10.67819640
72PTK60.67320763
73RPS6KB20.67179491
74MAPK150.66855407
75NTRK20.64201978
76CHEK10.62761834
77PASK0.62294985
78SIK20.60565891
79CAMK1D0.58465865
80UHMK10.58258141
81PTK20.57867839
82ROCK20.56861561
83ALK0.55006310
84CDK60.54634786
85PRKCI0.54015176
86EPHA20.52067716
87NME10.51479193
88PDGFRB0.50975296
89PDK10.50963776
90STK240.48995950
91CDK150.48844590
92ARAF0.48539011
93IRAK20.44721821
94CDK140.44388028
95TSSK60.44077972
96CDK180.43557470
97CDK11A0.42973102
98TAOK10.42904703
99FGFR10.42491992
100LIMK10.42012906
101ATM0.40652917
102RPS6KL10.40439144
103RPS6KC10.40439144
104CDK40.40328354
105HIPK20.39638744
106BRSK20.37894880
107RPS6KA10.37826472
108CDK20.37709454
109FER0.36855800
110STK110.36511227
111PRKD20.36293137
112AURKB0.36160233
113FGFR20.35805010
114PDPK10.35538907
115PLK10.35385464
116MKNK10.35053054
117CDK70.34418863
118CDK90.33982851
119ILK0.32572346
120AURKA0.31889807
121CSNK1D0.31821280
122ATR0.30554811
123CDK10.30470770
124MET0.29422775
125RPS6KA20.27982565
126GSK3B0.27062797
127CSNK1E0.26134432
128GSK3A0.24522078
129MAP3K80.24405311
130PAK30.24336505
131CLK10.23542079
132MAPK80.23402187
133DMPK0.23400986
134EPHB10.22915839
135CAMKK10.22338278
136TLK10.21920196
137ROCK10.20924263
138RPS6KA40.20758727
139PKN10.20622394
140CDC42BPA0.19928171
141PRKCZ0.19074315
142MAPK10.18850850
143SIK10.18841260
144NTRK10.18833824
145STK100.18530983

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000612.86232350
2Hedgehog signaling pathway_Homo sapiens_hsa043402.66221608
3Basal cell carcinoma_Homo sapiens_hsa052172.42685973
4mRNA surveillance pathway_Homo sapiens_hsa030152.16141571
5Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.89835448
6RNA transport_Homo sapiens_hsa030131.86544811
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.84563847
8Hippo signaling pathway_Homo sapiens_hsa043901.82639846
9Dorso-ventral axis formation_Homo sapiens_hsa043201.82411470
10Oocyte meiosis_Homo sapiens_hsa041141.75106664
11Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.72931008
12Axon guidance_Homo sapiens_hsa043601.68185659
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.56810118
14Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.53266769
15Glucagon signaling pathway_Homo sapiens_hsa049221.52437254
16DNA replication_Homo sapiens_hsa030301.46594255
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43408375
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.42863799
19Estrogen signaling pathway_Homo sapiens_hsa049151.42114559
20Central carbon metabolism in cancer_Homo sapiens_hsa052301.41128666
21Wnt signaling pathway_Homo sapiens_hsa043101.39079790
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.37241605
23Basal transcription factors_Homo sapiens_hsa030221.33953475
24Adherens junction_Homo sapiens_hsa045201.33338297
25Thyroid cancer_Homo sapiens_hsa052161.28032666
26ECM-receptor interaction_Homo sapiens_hsa045121.26546232
27Focal adhesion_Homo sapiens_hsa045101.25773170
28mTOR signaling pathway_Homo sapiens_hsa041501.24483537
29alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.23924618
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23771947
31MicroRNAs in cancer_Homo sapiens_hsa052061.23602809
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.21604159
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.21343423
34Systemic lupus erythematosus_Homo sapiens_hsa053221.20568918
35Linoleic acid metabolism_Homo sapiens_hsa005911.17885669
36Alcoholism_Homo sapiens_hsa050341.17372169
37Tight junction_Homo sapiens_hsa045301.16912198
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14920423
39Steroid biosynthesis_Homo sapiens_hsa001001.13622640
40Mismatch repair_Homo sapiens_hsa034301.13610993
41VEGF signaling pathway_Homo sapiens_hsa043701.12496520
42Cell cycle_Homo sapiens_hsa041101.12367262
43Spliceosome_Homo sapiens_hsa030401.10545058
44Viral carcinogenesis_Homo sapiens_hsa052031.09883506
45Small cell lung cancer_Homo sapiens_hsa052221.09531297
46Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.09212192
47Proteoglycans in cancer_Homo sapiens_hsa052051.08921356
48Sulfur relay system_Homo sapiens_hsa041221.08462673
49Notch signaling pathway_Homo sapiens_hsa043301.07679845
50Ribosome_Homo sapiens_hsa030101.03912826
51Chronic myeloid leukemia_Homo sapiens_hsa052201.02812849
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01746273
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00814281
54Colorectal cancer_Homo sapiens_hsa052101.00237698
55Renal cell carcinoma_Homo sapiens_hsa052111.00144153
56Endometrial cancer_Homo sapiens_hsa052130.99706110
57Bladder cancer_Homo sapiens_hsa052190.98866504
58TGF-beta signaling pathway_Homo sapiens_hsa043500.96785392
59Endocytosis_Homo sapiens_hsa041440.96680047
60Base excision repair_Homo sapiens_hsa034100.96317095
61AMPK signaling pathway_Homo sapiens_hsa041520.94280698
62Glioma_Homo sapiens_hsa052140.92558531
63Amphetamine addiction_Homo sapiens_hsa050310.92443922
64Viral myocarditis_Homo sapiens_hsa054160.92229313
65Protein digestion and absorption_Homo sapiens_hsa049740.91470389
66RNA polymerase_Homo sapiens_hsa030200.91115007
67Nucleotide excision repair_Homo sapiens_hsa034200.90613588
68Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88876749
69Folate biosynthesis_Homo sapiens_hsa007900.87174269
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85792365
71Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.85316100
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85230684
73Melanogenesis_Homo sapiens_hsa049160.84690489
74Fanconi anemia pathway_Homo sapiens_hsa034600.83922307
75Gap junction_Homo sapiens_hsa045400.83352159
76Lysine degradation_Homo sapiens_hsa003100.83170995
77Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.83127329
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.82260452
79Prostate cancer_Homo sapiens_hsa052150.81621855
80HTLV-I infection_Homo sapiens_hsa051660.80745592
81Pathways in cancer_Homo sapiens_hsa052000.78569549
82Pyruvate metabolism_Homo sapiens_hsa006200.76286160
83Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75878869
84Biosynthesis of amino acids_Homo sapiens_hsa012300.75745730
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.75181961
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74972807
87cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73936900
88Renin secretion_Homo sapiens_hsa049240.73027687
89Long-term potentiation_Homo sapiens_hsa047200.71066834
90MAPK signaling pathway_Homo sapiens_hsa040100.69053115
91ErbB signaling pathway_Homo sapiens_hsa040120.68150852
92p53 signaling pathway_Homo sapiens_hsa041150.68135262
93Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66032930
94Rap1 signaling pathway_Homo sapiens_hsa040150.65627088
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.64969525
96Ether lipid metabolism_Homo sapiens_hsa005650.64348725
97N-Glycan biosynthesis_Homo sapiens_hsa005100.64195817
98Selenocompound metabolism_Homo sapiens_hsa004500.63485216
99Amoebiasis_Homo sapiens_hsa051460.62448268
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62239496
101HIF-1 signaling pathway_Homo sapiens_hsa040660.61587588
102PI3K-Akt signaling pathway_Homo sapiens_hsa041510.60733705
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.58182962
104Cocaine addiction_Homo sapiens_hsa050300.57965711
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57925435
106Dilated cardiomyopathy_Homo sapiens_hsa054140.57681516
107Vitamin B6 metabolism_Homo sapiens_hsa007500.57075033
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.56936230
109Pyrimidine metabolism_Homo sapiens_hsa002400.56736241
110Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56628854
111Cardiac muscle contraction_Homo sapiens_hsa042600.56544691
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.56112604
113Insulin signaling pathway_Homo sapiens_hsa049100.55352141
114One carbon pool by folate_Homo sapiens_hsa006700.54826283
115Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.53375492
116Melanoma_Homo sapiens_hsa052180.52606742
117Mineral absorption_Homo sapiens_hsa049780.50128304
118Acute myeloid leukemia_Homo sapiens_hsa052210.50120047
119Homologous recombination_Homo sapiens_hsa034400.49878097
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.49835004
121Salmonella infection_Homo sapiens_hsa051320.49676583
122Non-small cell lung cancer_Homo sapiens_hsa052230.49262902
123Huntingtons disease_Homo sapiens_hsa050160.49201244
124Thyroid hormone synthesis_Homo sapiens_hsa049180.48649273
125Shigellosis_Homo sapiens_hsa051310.48444400
126Arginine and proline metabolism_Homo sapiens_hsa003300.46431702
127RNA degradation_Homo sapiens_hsa030180.44763141
128Vibrio cholerae infection_Homo sapiens_hsa051100.39666420
129Type II diabetes mellitus_Homo sapiens_hsa049300.38359302
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.37582848
131Taste transduction_Homo sapiens_hsa047420.32846070

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