MFAP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of retinoic acid receptor signaling pathway (GO:0048387)5.67051431
2establishment of integrated proviral latency (GO:0075713)5.10005245
3regulation of retinoic acid receptor signaling pathway (GO:0048385)4.98588905
4mitotic metaphase plate congression (GO:0007080)4.93429509
5CENP-A containing nucleosome assembly (GO:0034080)4.91944395
6chromatin remodeling at centromere (GO:0031055)4.85902782
7protein localization to kinetochore (GO:0034501)4.74145873
8ribosome assembly (GO:0042255)4.61367088
9protein localization to chromosome, centromeric region (GO:0071459)4.42930667
10metaphase plate congression (GO:0051310)4.42427464
11DNA strand elongation involved in DNA replication (GO:0006271)4.16288140
12histone exchange (GO:0043486)4.16183065
13proteasome assembly (GO:0043248)4.11056486
14DNA replication-independent nucleosome organization (GO:0034724)4.09035376
15DNA replication-independent nucleosome assembly (GO:0006336)4.09035376
16mitotic chromosome condensation (GO:0007076)4.06133594
17DNA strand elongation (GO:0022616)4.02856693
18DNA ligation (GO:0006266)3.93175404
19establishment of viral latency (GO:0019043)3.89227763
20telomere maintenance via semi-conservative replication (GO:0032201)3.87211126
21mitotic sister chromatid cohesion (GO:0007064)3.81570233
22DNA replication checkpoint (GO:0000076)3.79880309
23mitotic sister chromatid segregation (GO:0000070)3.78781342
24establishment of chromosome localization (GO:0051303)3.70342478
25regulation of DNA endoreduplication (GO:0032875)3.69667004
26DNA unwinding involved in DNA replication (GO:0006268)3.68723585
27kinetochore organization (GO:0051383)3.67037973
28regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.62910035
29DNA replication-dependent nucleosome assembly (GO:0006335)3.60146301
30DNA replication-dependent nucleosome organization (GO:0034723)3.60146301
31nuclear pore complex assembly (GO:0051292)3.57514760
32sister chromatid segregation (GO:0000819)3.57203764
33DNA topological change (GO:0006265)3.56160003
34formation of translation preinitiation complex (GO:0001731)3.55955554
35establishment of protein localization to mitochondrial membrane (GO:0090151)3.53989624
36DNA damage response, detection of DNA damage (GO:0042769)3.51217282
37spindle checkpoint (GO:0031577)3.49804447
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.48737765
39regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.45485863
40negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44308916
41mitotic recombination (GO:0006312)3.39989904
42regulation of centriole replication (GO:0046599)3.36277520
43protein localization to chromosome (GO:0034502)3.31565695
44telomere maintenance via recombination (GO:0000722)3.29828351
45mitotic spindle checkpoint (GO:0071174)3.29678099
46spliceosomal snRNP assembly (GO:0000387)3.28823966
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.26473584
48telomere maintenance via telomere lengthening (GO:0010833)3.26252459
49kinetochore assembly (GO:0051382)3.25961257
50ATP-dependent chromatin remodeling (GO:0043044)3.23829435
51non-recombinational repair (GO:0000726)3.22369454
52double-strand break repair via nonhomologous end joining (GO:0006303)3.22369454
53somatic hypermutation of immunoglobulin genes (GO:0016446)3.20363260
54somatic diversification of immune receptors via somatic mutation (GO:0002566)3.20363260
55cullin deneddylation (GO:0010388)3.18116111
56attachment of spindle microtubules to kinetochore (GO:0008608)3.17546367
577-methylguanosine mRNA capping (GO:0006370)3.17488773
58ribosome biogenesis (GO:0042254)3.17382304
59DNA replication initiation (GO:0006270)3.17240895
60regulation of chromosome segregation (GO:0051983)3.16654514
61negative regulation of ligase activity (GO:0051352)3.15122658
62negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.15122658
63regulation of spindle organization (GO:0090224)3.11459750
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.11420141
65IMP biosynthetic process (GO:0006188)3.08515475
667-methylguanosine RNA capping (GO:0009452)3.08215252
67RNA capping (GO:0036260)3.08215252
68chromosome segregation (GO:0007059)3.06654748
69ribosomal large subunit biogenesis (GO:0042273)3.06444142
70negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05830829
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.05830829
72negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05830829
73negative regulation of mitotic sister chromatid separation (GO:2000816)3.05830829
74negative regulation of sister chromatid segregation (GO:0033046)3.05830829
75negative regulation of chromosome segregation (GO:0051985)3.05445292
76nuclear pore organization (GO:0006999)3.05210919
77positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.03205089
78chromatin assembly or disassembly (GO:0006333)3.02556643
79DNA double-strand break processing (GO:0000729)3.02203116
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.01392154
81transcription-coupled nucleotide-excision repair (GO:0006283)2.99466479
82regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.97123049
83chaperone-mediated protein transport (GO:0072321)2.96941032
84regulation of mitotic metaphase/anaphase transition (GO:0030071)2.96789278
85regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.96789278
86rRNA modification (GO:0000154)2.93238279
87spindle assembly checkpoint (GO:0071173)2.91752706
88postreplication repair (GO:0006301)2.90712427
89histone mRNA metabolic process (GO:0008334)2.90506164
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.89873270
91negative regulation of DNA-dependent DNA replication (GO:2000104)2.89637229
92mitotic spindle assembly checkpoint (GO:0007094)2.89275901
93ribonucleoprotein complex biogenesis (GO:0022613)2.88645208
94positive regulation of ligase activity (GO:0051351)2.88639423
95negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.87990764
96regulation of transcription from RNA polymerase I promoter (GO:0006356)2.87651118
97transcription from mitochondrial promoter (GO:0006390)2.86680594
98protein deneddylation (GO:0000338)2.86559996
99purine nucleobase biosynthetic process (GO:0009113)2.85779751
100G1/S transition of mitotic cell cycle (GO:0000082)2.85098896

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.99277250
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.95830930
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.10875390
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.98756405
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.92679693
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.73413893
7* EST1_17652178_ChIP-ChIP_JURKAT_Human3.65623040
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.52708953
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.40717693
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.04030465
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.94583817
12JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.94206434
13* ETS1_20019798_ChIP-Seq_JURKAT_Human2.91260360
14ELK1_19687146_ChIP-ChIP_HELA_Human2.77386936
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.74121268
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.61338741
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61055110
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.52422057
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.51735322
20AR_21909140_ChIP-Seq_LNCAP_Human2.51315487
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.46105544
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.39110912
23PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.38230300
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37971238
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.33121271
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.31843360
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.31437111
28* VDR_23849224_ChIP-Seq_CD4+_Human2.29260180
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.23695760
30ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18471632
31FOXP3_21729870_ChIP-Seq_TREG_Human2.15716208
32DCP1A_22483619_ChIP-Seq_HELA_Human2.08345712
33YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.03839130
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02311800
35MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00594837
36TTF2_22483619_ChIP-Seq_HELA_Human2.00310500
37XRN2_22483619_ChIP-Seq_HELA_Human1.99939129
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.99190262
39FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.97952000
40* E2F1_21310950_ChIP-Seq_MCF-7_Human1.97898519
41E2F1_18555785_ChIP-Seq_MESCs_Mouse1.97257586
42PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94377684
43GABP_19822575_ChIP-Seq_HepG2_Human1.88396252
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75341425
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.75188887
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.74937429
47MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67564186
48* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62762482
49YY1_21170310_ChIP-Seq_MESCs_Mouse1.60781095
50SRF_21415370_ChIP-Seq_HL-1_Mouse1.59877891
51* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.53237291
52MYC_18940864_ChIP-ChIP_HL60_Human1.51614611
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46882643
54POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40898714
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.38529496
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.28701398
57CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27904588
58POU5F1_16153702_ChIP-ChIP_HESCs_Human1.27600927
59CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.27449525
60SOX2_16153702_ChIP-ChIP_HESCs_Human1.23310882
61ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22492402
62PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.22479398
63* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.21897211
64TP63_19390658_ChIP-ChIP_HaCaT_Human1.18417519
65SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14730578
66TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14644148
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.14509257
68EWS_26573619_Chip-Seq_HEK293_Human1.13586000
69KDM5A_27292631_Chip-Seq_BREAST_Human1.12631565
70ZNF274_21170338_ChIP-Seq_K562_Hela1.11386443
71NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.06954067
72ERG_20887958_ChIP-Seq_HPC-7_Mouse1.04639531
73SOX17_20123909_ChIP-Seq_XEN_Mouse1.03777584
74CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96713376
75CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96021278
76SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.94304940
77ELK1_22589737_ChIP-Seq_MCF10A_Human0.92264960
78BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.88555010
79FUS_26573619_Chip-Seq_HEK293_Human0.85348020
80IRF1_19129219_ChIP-ChIP_H3396_Human0.85247619
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82475343
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.82294711
83TFEB_21752829_ChIP-Seq_HELA_Human0.82279069
84TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.81030782
85CIITA_25753668_ChIP-Seq_RAJI_Human0.78359131
86CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77464922
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.76333851
88POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.76215480
89CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.75718175
90SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.75635672
91* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74879290
92* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74878789
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.74849718
94KLF4_18555785_ChIP-Seq_MESCs_Mouse0.74306705
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.72579741
96GATA1_26923725_Chip-Seq_HPCs_Mouse0.70522950
97TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.70166503
98ESR1_15608294_ChIP-ChIP_MCF-7_Human0.69567485
99NANOG_21062744_ChIP-ChIP_HESCs_Human0.69550996
100NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.68152207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.23574750
2MP0010094_abnormal_chromosome_stability4.65691008
3MP0004957_abnormal_blastocyst_morpholog4.41445207
4MP0008058_abnormal_DNA_repair4.29621525
5MP0003111_abnormal_nucleus_morphology4.12586011
6MP0003077_abnormal_cell_cycle3.43701527
7MP0008932_abnormal_embryonic_tissue3.16939110
8MP0008057_abnormal_DNA_replication2.80414752
9MP0008007_abnormal_cellular_replicative2.75433866
10MP0008877_abnormal_DNA_methylation2.70813255
11MP0003718_maternal_effect2.65273577
12MP0006292_abnormal_olfactory_placode2.33187421
13MP0001730_embryonic_growth_arrest2.13034907
14MP0003806_abnormal_nucleotide_metabolis2.06581121
15MP0001293_anophthalmia2.03553309
16MP0003315_abnormal_perineum_morphology1.92651934
17MP0003941_abnormal_skin_development1.84208060
18MP0000350_abnormal_cell_proliferation1.76834572
19MP0003186_abnormal_redox_activity1.65767848
20MP0001697_abnormal_embryo_size1.62966588
21MP0001672_abnormal_embryogenesis/_devel1.61212266
22MP0005380_embryogenesis_phenotype1.61212266
23MP0003121_genomic_imprinting1.59876534
24MP0003890_abnormal_embryonic-extraembry1.59413250
25MP0008789_abnormal_olfactory_epithelium1.54617083
26MP0002085_abnormal_embryonic_tissue1.53809470
27MP0002210_abnormal_sex_determination1.53218036
28MP0002084_abnormal_developmental_patter1.48849631
29MP0010030_abnormal_orbit_morphology1.47861595
30MP0009697_abnormal_copulation1.43794260
31MP0003786_premature_aging1.43380581
32MP0003984_embryonic_growth_retardation1.37907710
33MP0003567_abnormal_fetal_cardiomyocyte1.37188215
34MP0002102_abnormal_ear_morphology1.37053014
35MP0002080_prenatal_lethality1.36304203
36MP0003011_delayed_dark_adaptation1.33599843
37MP0005499_abnormal_olfactory_system1.33426183
38MP0005394_taste/olfaction_phenotype1.33426183
39MP0003937_abnormal_limbs/digits/tail_de1.32659227
40MP0002088_abnormal_embryonic_growth/wei1.31748039
41MP0001929_abnormal_gametogenesis1.30159495
42MP0010307_abnormal_tumor_latency1.29645140
43MP0000313_abnormal_cell_death1.26358684
44MP0001286_abnormal_eye_development1.23859521
45MP0000358_abnormal_cell_content/1.23391283
46MP0006035_abnormal_mitochondrial_morpho1.22263141
47MP0006072_abnormal_retinal_apoptosis1.20983037
48MP0004197_abnormal_fetal_growth/weight/1.19654567
49MP0002697_abnormal_eye_size1.19574917
50MP0001145_abnormal_male_reproductive1.18078737
51MP0001529_abnormal_vocalization1.17903470
52MP0005248_abnormal_Harderian_gland1.17665000
53MP0009672_abnormal_birth_weight1.16425350
54MP0000653_abnormal_sex_gland1.11919355
55MP0005084_abnormal_gallbladder_morpholo1.09706680
56MP0002233_abnormal_nose_morphology1.09466345
57MP0003221_abnormal_cardiomyocyte_apopto1.09236716
58MP0002938_white_spotting1.08325448
59MP0000372_irregular_coat_pigmentation1.08245068
60MP0002234_abnormal_pharynx_morphology1.08201137
61MP0001346_abnormal_lacrimal_gland1.07195025
62MP0003755_abnormal_palate_morphology1.02242207
63MP0003123_paternal_imprinting1.01874837
64MP0000647_abnormal_sebaceous_gland1.01565841
65MP0006036_abnormal_mitochondrial_physio0.97533425
66MP0005391_vision/eye_phenotype0.95348665
67MP0008995_early_reproductive_senescence0.94340819
68MP0005253_abnormal_eye_physiology0.93441016
69MP0003861_abnormal_nervous_system0.91805570
70MP0001119_abnormal_female_reproductive0.91574742
71MP0002751_abnormal_autonomic_nervous0.90932061
72MP0002086_abnormal_extraembryonic_tissu0.90821867
73MP0005501_abnormal_skin_physiology0.90009692
74MP0000049_abnormal_middle_ear0.88825610
75MP0002092_abnormal_eye_morphology0.88702532
76MP0003119_abnormal_digestive_system0.88699544
77MP0001727_abnormal_embryo_implantation0.88270481
78MP0002877_abnormal_melanocyte_morpholog0.85379171
79MP0002111_abnormal_tail_morphology0.85163823
80MP0003122_maternal_imprinting0.82724038
81MP0001188_hyperpigmentation0.82596215
82MP0001764_abnormal_homeostasis0.81597308
83MP0000579_abnormal_nail_morphology0.80886413
84MP0002160_abnormal_reproductive_system0.79276577
85MP0009703_decreased_birth_body0.79078498
86MP0000778_abnormal_nervous_system0.78505779
87MP0003385_abnormal_body_wall0.77738373
88MP0003698_abnormal_male_reproductive0.77549656
89MP0005187_abnormal_penis_morphology0.75767515
90MP0005395_other_phenotype0.74606765
91MP0006276_abnormal_autonomic_nervous0.73032788
92MP0002161_abnormal_fertility/fecundity0.72483217
93MP0002638_abnormal_pupillary_reflex0.71923092
94MP0002736_abnormal_nociception_after0.70892122
95MP0003880_abnormal_central_pattern0.69654953
96MP0000490_abnormal_crypts_of0.69637622
97MP0003699_abnormal_female_reproductive0.69314377
98MP0003935_abnormal_craniofacial_develop0.68105454
99MP0005384_cellular_phenotype0.65522407
100MP0005197_abnormal_uvea_morphology0.61956005

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.50914559
2Abnormality of the labia minora (HP:0012880)3.47153423
3Chromsome breakage (HP:0040012)3.39946811
4Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35963981
5Abnormal lung lobation (HP:0002101)3.34380011
6Abnormal mitochondria in muscle tissue (HP:0008316)3.19097422
7Acute necrotizing encephalopathy (HP:0006965)3.13060172
8Abnormality of chromosome stability (HP:0003220)2.99635110
9Meckel diverticulum (HP:0002245)2.95125583
10Birth length less than 3rd percentile (HP:0003561)2.92875716
11Cortical dysplasia (HP:0002539)2.89437562
12Acute encephalopathy (HP:0006846)2.87995432
13Multiple enchondromatosis (HP:0005701)2.87340786
14Microvesicular hepatic steatosis (HP:0001414)2.83302054
15Abnormality of the ileum (HP:0001549)2.72121891
16Increased serum pyruvate (HP:0003542)2.71384770
17Nephroblastoma (Wilms tumor) (HP:0002667)2.68001776
18Aplasia/Hypoplasia of the uvula (HP:0010293)2.65219972
19Abnormality of the preputium (HP:0100587)2.62539816
20Increased CSF lactate (HP:0002490)2.58214273
21Horseshoe kidney (HP:0000085)2.52390045
22Abnormality of glycolysis (HP:0004366)2.51904426
23Embryonal renal neoplasm (HP:0011794)2.51638022
24Shoulder girdle muscle weakness (HP:0003547)2.49649779
25Increased hepatocellular lipid droplets (HP:0006565)2.46563264
26Oligodactyly (hands) (HP:0001180)2.44230555
27Mitochondrial inheritance (HP:0001427)2.43015430
28Progressive macrocephaly (HP:0004481)2.35719623
29Abnormality of the anterior horn cell (HP:0006802)2.34588355
30Degeneration of anterior horn cells (HP:0002398)2.34588355
31Medulloblastoma (HP:0002885)2.34370817
32Increased nuchal translucency (HP:0010880)2.32898815
33Small intestinal stenosis (HP:0012848)2.31034252
34Duodenal stenosis (HP:0100867)2.31034252
35Carpal bone hypoplasia (HP:0001498)2.30893946
36Supernumerary spleens (HP:0009799)2.28988045
37Cerebral edema (HP:0002181)2.27031678
38Decreased activity of mitochondrial respiratory chain (HP:0008972)2.26676079
39Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.26676079
40Hypoplastic pelvis (HP:0008839)2.23886701
41Reticulocytopenia (HP:0001896)2.22108130
42Colon cancer (HP:0003003)2.19119314
43Abnormality of the septum pellucidum (HP:0007375)2.18311197
44Lipid accumulation in hepatocytes (HP:0006561)2.13574305
45Agnosia (HP:0010524)2.13078470
46Increased serum lactate (HP:0002151)2.12557574
47Hyperglycinemia (HP:0002154)2.07944204
48Abnormality of cells of the erythroid lineage (HP:0012130)2.06954756
49Aplastic anemia (HP:0001915)2.03020884
50Abnormality of the duodenum (HP:0002246)2.02620895
51Hepatocellular necrosis (HP:0001404)2.02536560
52Oligodactyly (HP:0012165)1.99629324
53Gonadotropin excess (HP:0000837)1.98586456
54Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97091122
55Degeneration of the lateral corticospinal tracts (HP:0002314)1.97091122
56Septo-optic dysplasia (HP:0100842)1.96298836
57Methylmalonic acidemia (HP:0002912)1.95865408
58Renal Fanconi syndrome (HP:0001994)1.95841141
59Atrophy/Degeneration involving motor neurons (HP:0007373)1.94504665
60Sloping forehead (HP:0000340)1.93753589
61Type I transferrin isoform profile (HP:0003642)1.93393954
62Hepatic necrosis (HP:0002605)1.91316497
63Rhabdomyosarcoma (HP:0002859)1.90591156
64Median cleft lip (HP:0000161)1.88310300
65Neoplasm of the adrenal gland (HP:0100631)1.86274707
66Ependymoma (HP:0002888)1.86183599
67Myelodysplasia (HP:0002863)1.85184033
68Abnormality of the corticospinal tract (HP:0002492)1.84728088
69Abnormal hair whorl (HP:0010721)1.84073848
70Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83975055
71Absent septum pellucidum (HP:0001331)1.83083458
72Increased intramyocellular lipid droplets (HP:0012240)1.81669343
73Proximal placement of thumb (HP:0009623)1.79966183
74Stenosis of the external auditory canal (HP:0000402)1.78401592
75Oral leukoplakia (HP:0002745)1.78133916
76Squamous cell carcinoma (HP:0002860)1.77227579
77Aplasia/hypoplasia of the uterus (HP:0008684)1.75517034
78Lactic acidosis (HP:0003128)1.75461614
79Premature ovarian failure (HP:0008209)1.75330973
80High anterior hairline (HP:0009890)1.73726487
81Short tibia (HP:0005736)1.73693072
82Leukodystrophy (HP:0002415)1.71060874
83Macrocytic anemia (HP:0001972)1.70796851
84Aplasia/Hypoplasia of the sternum (HP:0006714)1.69967193
85Amniotic constriction ring (HP:0009775)1.69162124
86Abnormality of placental membranes (HP:0011409)1.69162124
87Absent radius (HP:0003974)1.68609807
88Abnormal number of erythroid precursors (HP:0012131)1.68440541
89Abnormal number of incisors (HP:0011064)1.68374415
90Ectopic kidney (HP:0000086)1.67764345
91Triphalangeal thumb (HP:0001199)1.67581865
92Hemivertebrae (HP:0002937)1.67529403
93Reduced antithrombin III activity (HP:0001976)1.67260213
94Hypoplasia of the uterus (HP:0000013)1.65538378
95Neoplasm of the colon (HP:0100273)1.65151318
96Postnatal microcephaly (HP:0005484)1.64857589
97Abnormality of serum amino acid levels (HP:0003112)1.64271583
98Spastic diplegia (HP:0001264)1.64224812
99Abnormality of methionine metabolism (HP:0010901)1.63948818
100Facial cleft (HP:0002006)1.63476289

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.90087867
2BUB13.85584177
3SRPK13.73833233
4TTK3.18244770
5NEK13.07553215
6EIF2AK33.06148991
7TSSK62.89483806
8EIF2AK12.54115094
9PLK42.51513462
10PLK32.38177646
11MST42.34567183
12PBK2.24511703
13MKNK12.10460905
14WEE12.10347458
15STK162.09527420
16TNIK1.96137093
17PLK11.93680041
18VRK21.91983504
19TRIM281.75421741
20NME11.73510960
21MKNK21.63974069
22PLK21.60112635
23NEK21.51541722
24BCR1.47845887
25VRK11.45438799
26PNCK1.40343748
27BRSK21.39691380
28AURKB1.31542761
29WNK31.29997143
30ATR1.29625313
31KDR1.17845730
32NUAK11.15595827
33ZAK1.12790054
34BRD41.12555068
35RPS6KA41.08374206
36CHEK11.07599963
37CCNB11.06882619
38PDK21.03222892
39CHEK21.01540259
40BRSK11.00086088
41AURKA0.98953084
42CLK10.97201001
43BMPR1B0.95105500
44TAF10.93685760
45CDK120.91855971
46CDK70.91746249
47CDK30.87894954
48ATM0.85684146
49PASK0.82552631
50STK40.80743012
51STK240.78984799
52NTRK10.76803749
53ALK0.76282211
54MAP3K40.76200173
55DYRK20.72990009
56STK38L0.72255480
57LATS20.71623899
58EIF2AK20.70652501
59* CSNK2A20.69604284
60CSNK2A10.69437437
61CDK20.68571935
62CDK11A0.68236525
63SCYL20.67937839
64CDK180.66906252
65CDK190.66060505
66CSNK1G20.65815104
67CDK140.64748531
68CDK150.63998299
69NEK90.63127246
70CDK10.62379597
71MAP3K90.61517336
72RAF10.61068327
73ERBB40.60197916
74MAP3K80.60118896
75* CSNK1E0.60037236
76ERBB30.58413672
77CSNK1G10.58066098
78NME20.55470331
79EPHB20.55238310
80STK100.54323246
81DYRK30.53804526
82CSNK1G30.53172746
83BRAF0.50323870
84STK30.49231820
85CDK80.49091539
86CDK40.48663590
87KSR10.48623395
88MAP2K70.48306665
89PRKCI0.48060199
90CDK90.47207552
91ARAF0.41039215
92YES10.39858039
93RPS6KB20.38416938
94PRKDC0.37006205
95AKT20.36832307
96MAP4K20.32102590
97TGFBR10.31531610
98CSNK1A1L0.31235064
99MINK10.29518224
100RPS6KA50.27517517

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034303.95097615
2DNA replication_Homo sapiens_hsa030303.90978757
3Proteasome_Homo sapiens_hsa030503.69092744
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.64965761
5Spliceosome_Homo sapiens_hsa030403.07756791
6Protein export_Homo sapiens_hsa030602.91206212
7Non-homologous end-joining_Homo sapiens_hsa034502.85492341
8RNA polymerase_Homo sapiens_hsa030202.85041876
9Homologous recombination_Homo sapiens_hsa034402.79278248
10RNA transport_Homo sapiens_hsa030132.70626789
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.67104676
12Ribosome_Homo sapiens_hsa030102.54057070
13Nucleotide excision repair_Homo sapiens_hsa034202.53164375
14Basal transcription factors_Homo sapiens_hsa030222.51418673
15Base excision repair_Homo sapiens_hsa034102.50507304
16Cell cycle_Homo sapiens_hsa041102.46130011
17Fanconi anemia pathway_Homo sapiens_hsa034602.17936776
18RNA degradation_Homo sapiens_hsa030182.05551718
19Oxidative phosphorylation_Homo sapiens_hsa001901.96721818
20Parkinsons disease_Homo sapiens_hsa050121.85119070
21mRNA surveillance pathway_Homo sapiens_hsa030151.82155409
22Pyrimidine metabolism_Homo sapiens_hsa002401.71832183
23One carbon pool by folate_Homo sapiens_hsa006701.69086307
24Huntingtons disease_Homo sapiens_hsa050161.54396331
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.49523005
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45295760
27Folate biosynthesis_Homo sapiens_hsa007901.34467189
28Fatty acid elongation_Homo sapiens_hsa000621.31206698
29Cysteine and methionine metabolism_Homo sapiens_hsa002701.28551846
30Pyruvate metabolism_Homo sapiens_hsa006201.27821647
31Propanoate metabolism_Homo sapiens_hsa006401.27590970
32Oocyte meiosis_Homo sapiens_hsa041141.27241620
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.25351572
34Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.21004555
35Steroid biosynthesis_Homo sapiens_hsa001001.20937509
36Purine metabolism_Homo sapiens_hsa002301.19722825
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19312046
38Biosynthesis of amino acids_Homo sapiens_hsa012301.07561003
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.06503554
40Carbon metabolism_Homo sapiens_hsa012001.02853537
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.02853032
42p53 signaling pathway_Homo sapiens_hsa041151.00158095
43Alzheimers disease_Homo sapiens_hsa050100.96178422
442-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.92587525
45Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.89022464
46Selenocompound metabolism_Homo sapiens_hsa004500.87866345
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79133507
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.78319099
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75342324
50Glutathione metabolism_Homo sapiens_hsa004800.73201891
51Regulation of autophagy_Homo sapiens_hsa041400.72087486
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.71821032
53Epstein-Barr virus infection_Homo sapiens_hsa051690.69525246
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.68915776
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66830884
56Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63021702
57Vitamin B6 metabolism_Homo sapiens_hsa007500.57827348
58Sulfur metabolism_Homo sapiens_hsa009200.51344265
59Pentose phosphate pathway_Homo sapiens_hsa000300.48259601
60Metabolic pathways_Homo sapiens_hsa011000.48180696
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46319724
62Hedgehog signaling pathway_Homo sapiens_hsa043400.45563637
63TGF-beta signaling pathway_Homo sapiens_hsa043500.45212858
64Hippo signaling pathway_Homo sapiens_hsa043900.44959117
65Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42063950
66Cardiac muscle contraction_Homo sapiens_hsa042600.41878597
67Peroxisome_Homo sapiens_hsa041460.41573936
68Butanoate metabolism_Homo sapiens_hsa006500.40476919
69Basal cell carcinoma_Homo sapiens_hsa052170.39887204
70Fatty acid metabolism_Homo sapiens_hsa012120.39043168
71Adherens junction_Homo sapiens_hsa045200.38581606
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36942760
73Wnt signaling pathway_Homo sapiens_hsa043100.36132183
74Collecting duct acid secretion_Homo sapiens_hsa049660.34005091
75N-Glycan biosynthesis_Homo sapiens_hsa005100.30833899
76Thyroid cancer_Homo sapiens_hsa052160.30712867
77Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30385611
78Viral carcinogenesis_Homo sapiens_hsa052030.29123910
79Arginine and proline metabolism_Homo sapiens_hsa003300.26792060
80Vibrio cholerae infection_Homo sapiens_hsa051100.25694276
81beta-Alanine metabolism_Homo sapiens_hsa004100.22212132
82MicroRNAs in cancer_Homo sapiens_hsa052060.21896756
83Herpes simplex infection_Homo sapiens_hsa051680.20893878
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.20686308
85Phototransduction_Homo sapiens_hsa047440.20409141
86Shigellosis_Homo sapiens_hsa051310.18550062
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.17607883
88Systemic lupus erythematosus_Homo sapiens_hsa053220.17202674
89Tight junction_Homo sapiens_hsa045300.17183331
90Central carbon metabolism in cancer_Homo sapiens_hsa052300.13653874
91Legionellosis_Homo sapiens_hsa051340.11877553
92Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.09082514
93Lysine degradation_Homo sapiens_hsa003100.08742803
94Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06072150
95HTLV-I infection_Homo sapiens_hsa051660.05394283
96Colorectal cancer_Homo sapiens_hsa052100.05324537
97Alcoholism_Homo sapiens_hsa050340.04187854
98Drug metabolism - other enzymes_Homo sapiens_hsa009830.03531918
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.03419248
100Galactose metabolism_Homo sapiens_hsa000520.02294722

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