ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	protein localization to cilium (GO:0061512)	6.38204888
2	retinal cone cell development (GO:0046549)	6.09259294
3	negative regulation of oligodendrocyte differentiation (GO:0048715)	5.34976263
4	atrial cardiac muscle cell action potential (GO:0086014)	5.32310697
5	response to nitrosative stress (GO:0051409)	5.32299908
6	cGMP-mediated signaling (GO:0019934)	5.11744156
7	negative regulation of inclusion body assembly (GO:0090084)	5.07581863
8	behavioral response to nicotine (GO:0035095)	4.84815703
9	presynaptic membrane assembly (GO:0097105)	4.73625684
10	microtubule severing (GO:0051013)	4.54853617
11	righting reflex (GO:0060013)	4.25725125
12	neuron cell-cell adhesion (GO:0007158)	4.25509115
13	limb bud formation (GO:0060174)	4.23347042
14	postsynaptic membrane organization (GO:0001941)	4.19959623
15	reflex (GO:0060004)	4.05127389
16	presynaptic membrane organization (GO:0097090)	4.02915044
17	otic vesicle formation (GO:0030916)	4.01773845
18	prepulse inhibition (GO:0060134)	3.98038312
19	pyrimidine nucleobase catabolic process (GO:0006208)	3.92674461
20	nonmotile primary cilium assembly (GO:0035058)	3.88721756
21	relaxation of smooth muscle (GO:0044557)	3.72349730
22	cardiac right ventricle morphogenesis (GO:0003215)	3.67722422
23	behavioral response to ethanol (GO:0048149)	3.65352625
24	detection of light stimulus involved in visual perception (GO:0050908)	3.60229901
25	detection of light stimulus involved in sensory perception (GO:0050962)	3.60229901
26	prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:006052	3.58710079
27	protein refolding (GO:0042026)	3.58300446
28	negative regulation of mast cell activation (GO:0033004)	3.55042413
29	retinal ganglion cell axon guidance (GO:0031290)	3.45787552
30	regulation of action potential (GO:0098900)	3.44967891
31	regulation of inclusion body assembly (GO:0090083)	3.43827253
32	transcription from mitochondrial promoter (GO:0006390)	3.43814351
33	regulation of dopamine secretion (GO:0014059)	3.37450553
34	water-soluble vitamin biosynthetic process (GO:0042364)	3.34840122
35	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.32725147
36	cAMP catabolic process (GO:0006198)	3.31813960
37	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.19616881
38	photoreceptor cell differentiation (GO:0046530)	3.10636523
39	eye photoreceptor cell differentiation (GO:0001754)	3.10636523
40	behavioral response to cocaine (GO:0048148)	3.06846229
41	thalamus development (GO:0021794)	3.05247144
42	artery development (GO:0060840)	3.04664804
43	regulation of respiratory system process (GO:0044065)	3.01211233
44	axon ensheathment in central nervous system (GO:0032291)	2.98721407
45	central nervous system myelination (GO:0022010)	2.98721407
46	cyclic nucleotide catabolic process (GO:0009214)	2.97861464
47	response to histamine (GO:0034776)	2.97388747
48	Sertoli cell development (GO:0060009)	2.97153797
49	adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)	2.95823179
50	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)	2.94137253
51	nucleobase catabolic process (GO:0046113)	2.92818125
52	DNA deamination (GO:0045006)	2.91344129
53	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.90975188
54	photoreceptor cell development (GO:0042461)	2.86227546
55	gamma-aminobutyric acid transport (GO:0015812)	2.84769505
56	regulation of short-term neuronal synaptic plasticity (GO:0048172)	2.84582351
57	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.84208548
58	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.82591473
59	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.82418257
60	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.82418257
61	dendritic spine morphogenesis (GO:0060997)	2.81963099
62	protein-cofactor linkage (GO:0018065)	2.81794318
63	sensory perception of smell (GO:0007608)	2.74437898
64	neuron recognition (GO:0008038)	2.72739264
65	auditory receptor cell stereocilium organization (GO:0060088)	2.71683761
66	vocalization behavior (GO:0071625)	2.71663787
67	regulation of respiratory gaseous exchange by neurological system process (GO:0002087)	2.70919477
68	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.69843108
69	short-term memory (GO:0007614)	2.69499284
70	negative regulation of glial cell differentiation (GO:0045686)	2.68381496
71	transmission of nerve impulse (GO:0019226)	2.68338885
72	eye photoreceptor cell development (GO:0042462)	2.68309278
73	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.67382577
74	radial glial cell differentiation (GO:0060019)	2.66295762
75	mRNA splice site selection (GO:0006376)	2.66100767
76	negative regulation of sodium ion transport (GO:0010766)	2.65733966
77	nephron tubule morphogenesis (GO:0072078)	2.65558361
78	nephron epithelium morphogenesis (GO:0072088)	2.65558361
79	neuronal stem cell maintenance (GO:0097150)	2.65440568
80	regulation of oligodendrocyte differentiation (GO:0048713)	2.63404549
81	regulation of neurotransmitter uptake (GO:0051580)	2.62639704
82	positive regulation of RNA splicing (GO:0033120)	2.62547229
83	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.61911459
84	glycerophospholipid catabolic process (GO:0046475)	2.60888675
85	synapse assembly (GO:0007416)	2.59604031
86	kidney morphogenesis (GO:0060993)	2.58606277
87	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.56469337
88	regulation of penile erection (GO:0060405)	2.56003724
89	negative regulation of androgen receptor signaling pathway (GO:0060766)	2.55763411
90	amino acid salvage (GO:0043102)	2.55605920
91	L-methionine salvage (GO:0071267)	2.55605920
92	L-methionine biosynthetic process (GO:0071265)	2.55605920
93	cilium morphogenesis (GO:0060271)	2.55202580
94	cerebral cortex radially oriented cell migration (GO:0021799)	2.54775640
95	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.54041389
96	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.54041389
97	NADH dehydrogenase complex assembly (GO:0010257)	2.54041389
98	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.52931488
99	positive regulation of dendritic spine development (GO:0060999)	2.52262134
100	adult feeding behavior (GO:0008343)	2.52113540

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.71119743
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.67084069
3	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.44467051
4	TAF15_26573619_Chip-Seq_HEK293_Human	3.27026999
5	GBX2_23144817_ChIP-Seq_PC3_Human	2.71300918
6	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.46583485
7	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.44505860
8	EZH2_22144423_ChIP-Seq_EOC_Human	2.43265148
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.42614019
10	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.42107565
11	IGF1R_20145208_ChIP-Seq_DFB_Human	2.34329849
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.33342827
13	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.23886600
14	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.20037607
15	REST_21632747_ChIP-Seq_MESCs_Mouse	2.19419673
16	FUS_26573619_Chip-Seq_HEK293_Human	2.14372909
17	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.09647761
18	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.06565570
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.04433662
20	RNF2_27304074_Chip-Seq_NSC_Mouse	2.04359237
21	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.03229429
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.02622784
23	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	2.01104955
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.98309991
25	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.96240153
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93336136
27	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.92195170
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.91319492
29	ER_23166858_ChIP-Seq_MCF-7_Human	1.88635687
30	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.86697817
31	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.80894456
32	P300_19829295_ChIP-Seq_ESCs_Human	1.79378398
33	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.77233660
34	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.77192663
35	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.73745608
36	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.71349823
37	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.71262935
38	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.70313848
39	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.68765628
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.68360471
41	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.68229157
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.68229157
43	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.64759664
44	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.64399332
45	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.60463620
46	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.59427441
47	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56458907
48	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.53904254
49	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.53904254
50	AR_21572438_ChIP-Seq_LNCaP_Human	1.53706995
51	SMAD4_21799915_ChIP-Seq_A2780_Human	1.51496712
52	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.50766348
53	BCAT_22108803_ChIP-Seq_LS180_Human	1.49955566
54	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.48534367
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47943313
56	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.46713197
57	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.45752101
58	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.45651801
59	EWS_26573619_Chip-Seq_HEK293_Human	1.44580623
60	STAT3_23295773_ChIP-Seq_U87_Human	1.40590838
61	AR_25329375_ChIP-Seq_VCAP_Human	1.36880027
62	CBP_20019798_ChIP-Seq_JUKART_Human	1.34022236
63	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.34022236
64	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.33432182
65	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.30849149
66	VDR_22108803_ChIP-Seq_LS180_Human	1.27634076
67	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.26668385
68	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.25025644
69	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.25004772
70	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20701626
71	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.20189750
72	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.19962465
73	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18827283
74	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.17945322
75	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.15593515
76	TCF4_22108803_ChIP-Seq_LS180_Human	1.15252029
77	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.14443320
78	SOX9_26525672_Chip-Seq_HEART_Mouse	1.12768744
79	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.11599020
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.11121541
81	TCF4_23295773_ChIP-Seq_U87_Human	1.10858361
82	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.10613432
83	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.10164583
84	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.09689187
85	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09616975
86	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.08923693
87	AR_19668381_ChIP-Seq_PC3_Human	1.05904629
88	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.01694674
89	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.01653980
90	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.01034447
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.00984052
92	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.00326742
93	ZNF274_21170338_ChIP-Seq_K562_Hela	1.00278335
94	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.98973611
95	TP53_18474530_ChIP-ChIP_U2OS_Human	0.98361245
96	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97407813
97	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.97397521
98	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.95637570
99	DROSHA_22980978_ChIP-Seq_HELA_Human	0.95306129
100	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.94784576

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	4.84769784
2	MP0001984_abnormal_olfaction	3.34038392
3	MP0004133_heterotaxia	3.12104957
4	MP0002822_catalepsy	3.03094871
5	MP0006292_abnormal_olfactory_placode	2.94473695
6	MP0005451_abnormal_body_composition	2.68638199
7	MP0004742_abnormal_vestibular_system	2.66893323
8	MP0003136_yellow_coat_color	2.66690054
9	MP0002734_abnormal_mechanical_nocicepti	2.38804805
10	MP0005171_absent_coat_pigmentation	2.35352386
11	MP0003787_abnormal_imprinting	2.29335926
12	MP0005423_abnormal_somatic_nervous	2.23292269
13	MP0006276_abnormal_autonomic_nervous	2.19964529
14	MP0000778_abnormal_nervous_system	2.12272730
15	MP0003121_genomic_imprinting	2.08444883
16	MP0004270_analgesia	2.04067690
17	MP0001486_abnormal_startle_reflex	1.94535939
18	MP0008877_abnormal_DNA_methylation	1.89478230
19	MP0006072_abnormal_retinal_apoptosis	1.88007252
20	MP0004859_abnormal_synaptic_plasticity	1.85264313
21	MP0002928_abnormal_bile_duct	1.82813013
22	MP0005551_abnormal_eye_electrophysiolog	1.82506663
23	MP0009745_abnormal_behavioral_response	1.80400693
24	MP0001440_abnormal_grooming_behavior	1.78948106
25	MP0003122_maternal_imprinting	1.75901839
26	MP0002572_abnormal_emotion/affect_behav	1.73786758
27	MP0003011_delayed_dark_adaptation	1.72126049
28	MP0003635_abnormal_synaptic_transmissio	1.71885080
29	MP0002063_abnormal_learning/memory/cond	1.70532306
30	MP0002736_abnormal_nociception_after	1.69019129
31	MP0002064_seizures	1.66858783
32	MP0002272_abnormal_nervous_system	1.66521969
33	MP0004885_abnormal_endolymph	1.65232481
34	MP0001485_abnormal_pinna_reflex	1.57256582
35	MP0001968_abnormal_touch/_nociception	1.53496454
36	MP0003283_abnormal_digestive_organ	1.51163205
37	MP0005253_abnormal_eye_physiology	1.50389542
38	MP0001177_atelectasis	1.47681200
39	MP0001970_abnormal_pain_threshold	1.46492322
40	MP0008872_abnormal_physiological_respon	1.44526426
41	MP0002249_abnormal_larynx_morphology	1.40381769
42	MP0003938_abnormal_ear_development	1.38587099
43	MP0000955_abnormal_spinal_cord	1.38457000
44	MP0000049_abnormal_middle_ear	1.37485432
45	MP0000631_abnormal_neuroendocrine_gland	1.36783588
46	MP0002557_abnormal_social/conspecific_i	1.28491954
47	MP0002752_abnormal_somatic_nervous	1.20176335
48	MP0005646_abnormal_pituitary_gland	1.19248126
49	MP0002735_abnormal_chemical_nociception	1.17797763
50	MP0004142_abnormal_muscle_tone	1.17522099
51	MP0001529_abnormal_vocalization	1.15692817
52	MP0002067_abnormal_sensory_capabilities	1.12110862
53	MP0003123_paternal_imprinting	1.10948143
54	MP0001502_abnormal_circadian_rhythm	1.10544125
55	MP0006035_abnormal_mitochondrial_morpho	1.06436310
56	MP0002282_abnormal_trachea_morphology	1.05834033
57	MP0002697_abnormal_eye_size	1.04723755
58	MP0003137_abnormal_impulse_conducting	1.04570388
59	MP0000026_abnormal_inner_ear	1.02013311
60	MP0004084_abnormal_cardiac_muscle	1.01753200
61	MP0005195_abnormal_posterior_eye	1.01300266
62	MP0002638_abnormal_pupillary_reflex	0.98494140
63	MP0002108_abnormal_muscle_morphology	0.97961562
64	MP0005503_abnormal_tendon_morphology	0.97851079
65	MP0002882_abnormal_neuron_morphology	0.97013250
66	MP0001905_abnormal_dopamine_level	0.95771221
67	MP0002184_abnormal_innervation	0.95436839
68	MP0009278_abnormal_bone_marrow	0.94562058
69	MP0003861_abnormal_nervous_system	0.93285868
70	MP0001963_abnormal_hearing_physiology	0.91317873
71	MP0003690_abnormal_glial_cell	0.91247688
72	MP0002152_abnormal_brain_morphology	0.90763354
73	MP0004811_abnormal_neuron_physiology	0.89383762
74	MP0001919_abnormal_reproductive_system	0.88997560
75	MP0009379_abnormal_foot_pigmentation	0.87882986
76	MP0004134_abnormal_chest_morphology	0.86276800
77	MP0001324_abnormal_eye_pigmentation	0.85814475
78	MP0005391_vision/eye_phenotype	0.84685307
79	MP0005084_abnormal_gallbladder_morpholo	0.84435499
80	MP0001501_abnormal_sleep_pattern	0.84072753
81	MP0009046_muscle_twitch	0.83968925
82	MP0004043_abnormal_pH_regulation	0.83172131
83	MP0004215_abnormal_myocardial_fiber	0.82919128
84	MP0002066_abnormal_motor_capabilities/c	0.82539698
85	MP0000579_abnormal_nail_morphology	0.82433764
86	MP0002938_white_spotting	0.82414127
87	MP0003221_abnormal_cardiomyocyte_apopto	0.82010290
88	MP0000534_abnormal_ureter_morphology	0.81528507
89	MP0005187_abnormal_penis_morphology	0.80660006
90	MP0005367_renal/urinary_system_phenotyp	0.79327686
91	MP0000516_abnormal_urinary_system	0.79327686
92	MP0005620_abnormal_muscle_contractility	0.78994999
93	MP0005389_reproductive_system_phenotype	0.78818854
94	MP0003890_abnormal_embryonic-extraembry	0.78086908
95	MP0002233_abnormal_nose_morphology	0.74515657
96	MP0003943_abnormal_hepatobiliary_system	0.73758509
97	MP0002332_abnormal_exercise_endurance	0.73683009
98	MP0001188_hyperpigmentation	0.71528951
99	MP0000647_abnormal_sebaceous_gland	0.68386556
100	MP0008569_lethality_at_weaning	0.67291694

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Genetic anticipation (HP:0003743)	4.29042585
2	Metaphyseal dysplasia (HP:0100255)	3.96179579
3	Exercise-induced muscle cramps (HP:0003710)	3.73243361
4	Congenital sensorineural hearing impairment (HP:0008527)	3.72471302
5	Abnormality of the labia minora (HP:0012880)	3.34209211
6	IgM deficiency (HP:0002850)	3.15085231
7	Tracheomalacia (HP:0002779)	3.02919845
8	Abnormality of the ischium (HP:0003174)	2.97742536
9	True hermaphroditism (HP:0010459)	2.94716937
10	Nephronophthisis (HP:0000090)	2.90585879
11	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.89685842
12	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.89685842
13	Bronchomalacia (HP:0002780)	2.82704846
14	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.81509919
15	Birth length less than 3rd percentile (HP:0003561)	2.80025808
16	Oligodactyly (HP:0012165)	2.80017247
17	Medial flaring of the eyebrow (HP:0010747)	2.77709455
18	Labial hypoplasia (HP:0000066)	2.76517692
19	Genital tract atresia (HP:0001827)	2.60322804
20	Hypoplastic female external genitalia (HP:0012815)	2.59824867
21	Pancreatic fibrosis (HP:0100732)	2.59148221
22	Hypoplastic labia majora (HP:0000059)	2.58372386
23	Nephrogenic diabetes insipidus (HP:0009806)	2.57191800
24	Gait imbalance (HP:0002141)	2.56659833
25	Oligodactyly (hands) (HP:0001180)	2.52759615
26	Molar tooth sign on MRI (HP:0002419)	2.50923394
27	Abnormality of midbrain morphology (HP:0002418)	2.50923394
28	Short tibia (HP:0005736)	2.49915609
29	Bilateral microphthalmos (HP:0007633)	2.46235779
30	Congenital primary aphakia (HP:0007707)	2.43686423
31	Azoospermia (HP:0000027)	2.38766711
32	Hypoglycemic seizures (HP:0002173)	2.37844609
33	Specific learning disability (HP:0001328)	2.37464004
34	Annular pancreas (HP:0001734)	2.37029439
35	Abnormality of the labia majora (HP:0012881)	2.36516031
36	Focal motor seizures (HP:0011153)	2.35821985
37	Fibular aplasia (HP:0002990)	2.33843322
38	Poor head control (HP:0002421)	2.33625125
39	Progressive cerebellar ataxia (HP:0002073)	2.33575582
40	Lissencephaly (HP:0001339)	2.32535243
41	Agitation (HP:0000713)	2.31052222
42	Bicornuate uterus (HP:0000813)	2.30688924
43	Abnormality of the renal medulla (HP:0100957)	2.23148944
44	Urinary urgency (HP:0000012)	2.22153836
45	Vaginal atresia (HP:0000148)	2.19695531
46	Abnormality of the labia (HP:0000058)	2.15129057
47	Ulnar claw (HP:0001178)	2.15059866
48	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.14285080
49	Aplasia involving bones of the extremities (HP:0009825)	2.11322802
50	Aplasia involving bones of the upper limbs (HP:0009823)	2.11322802
51	Aplasia of the phalanges of the hand (HP:0009802)	2.11322802
52	Concave nail (HP:0001598)	2.09258990
53	Abnormal number of incisors (HP:0011064)	2.08177860
54	Abnormality of the corticospinal tract (HP:0002492)	2.07700806
55	Horizontal nystagmus (HP:0000666)	2.07590463
56	Abnormality of the aortic arch (HP:0012303)	2.06535126
57	Myokymia (HP:0002411)	2.02066695
58	CNS hypomyelination (HP:0003429)	2.00235091
59	Methylmalonic aciduria (HP:0012120)	1.99372362
60	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.99156218
61	Febrile seizures (HP:0002373)	1.98820795
62	Abnormal spermatogenesis (HP:0008669)	1.98305490
63	Brushfield spots (HP:0001088)	1.97670411
64	Large for gestational age (HP:0001520)	1.96064856
65	Hypoplastic ischia (HP:0003175)	1.94407416
66	Poor coordination (HP:0002370)	1.93338772
67	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.92481605
68	Abnormality of lateral ventricle (HP:0030047)	1.91894621
69	Hyperinsulinemic hypoglycemia (HP:0000825)	1.91743603
70	Glossoptosis (HP:0000162)	1.91541745
71	Patellar aplasia (HP:0006443)	1.91454440
72	Hepatocellular necrosis (HP:0001404)	1.90616256
73	Scanning speech (HP:0002168)	1.90280405
74	Hyperventilation (HP:0002883)	1.90051572
75	Hypoglycemic coma (HP:0001325)	1.89328151
76	Patchy hypopigmentation of hair (HP:0011365)	1.88731601
77	Abnormality of the pubic bones (HP:0003172)	1.88181122
78	Aplasia/Hypoplasia of the patella (HP:0006498)	1.87643326
79	Hemiparesis (HP:0001269)	1.86089066
80	Scrotal hypoplasia (HP:0000046)	1.85155424
81	Heterochromia iridis (HP:0001100)	1.84390619
82	Esophageal atresia (HP:0002032)	1.83058788
83	Anophthalmia (HP:0000528)	1.81783629
84	Selective tooth agenesis (HP:0001592)	1.80164571
85	Sclerocornea (HP:0000647)	1.79762025
86	Peripheral hypomyelination (HP:0007182)	1.79138404
87	Abnormality of the phalanges of the 2nd finger (HP:0009541)	1.77899424
88	Impulsivity (HP:0100710)	1.77639673
89	Aplasia/Hypoplasia of the lens (HP:0008063)	1.76991697
90	Methylmalonic acidemia (HP:0002912)	1.76845748
91	Postaxial hand polydactyly (HP:0001162)	1.76265722
92	Myotonia (HP:0002486)	1.74836249
93	Abnormal drinking behavior (HP:0030082)	1.74824631
94	Polydipsia (HP:0001959)	1.74824631
95	Aqueductal stenosis (HP:0002410)	1.74337178
96	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.74121658
97	Pancreatic cysts (HP:0001737)	1.73116774
98	Pancreatic islet-cell hyperplasia (HP:0004510)	1.72837420
99	Breast aplasia (HP:0100783)	1.71410636
100	Polyuria (HP:0000103)	1.71374627

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TNIK	5.02527963
2	MAPK15	4.99531214
3	SIK2	3.52425905
4	CASK	3.33641079
5	TSSK6	3.08385611
6	PNCK	2.98586823
7	SCYL2	2.47747362
8	MAPKAPK5	2.43025893
9	PKN2	2.31143217
10	FRK	2.28844305
11	DYRK2	2.17175748
12	MARK1	2.01897332
13	EPHA4	1.96291722
14	MAPK13	1.88814187
15	INSRR	1.83552427
16	PAK3	1.60687849
17	FLT3	1.59252173
18	NTRK2	1.44085343
19	GRK1	1.35763725
20	MAP3K4	1.31479993
21	TAOK1	1.29082172
22	DYRK1B	1.28985316
23	NTRK3	1.27123981
24	DDR2	1.25836462
25	PINK1	1.25713438
26	SRPK1	1.24344282
27	MINK1	1.23777238
28	CSNK1G2	1.23492905
29	OBSCN	1.16834264
30	CDK3	1.12349831
31	OXSR1	1.06164972
32	EPHB2	0.97585228
33	MAP2K7	0.95876920
34	CAMK2A	0.95036884
35	DYRK3	0.94168231
36	UHMK1	0.93555396
37	FER	0.93520280
38	CHUK	0.92889156
39	STK39	0.90886108
40	PRKCG	0.88525940
41	PLK2	0.88404148
42	PAK6	0.85195921
43	DYRK1A	0.83527159
44	MARK2	0.83452439
45	STK38	0.83447650
46	MAP2K4	0.78790853
47	CSNK1A1L	0.78615403
48	ERBB2	0.76714034
49	PHKG1	0.76058559
50	PHKG2	0.76058559
51	MKNK2	0.74979654
52	MKNK1	0.73566025
53	PTK2B	0.72581294
54	PRKG1	0.72328796
55	CSNK1G1	0.71329850
56	CAMK2B	0.68600266
57	FGFR2	0.67909197
58	PRKD2	0.66148186
59	WEE1	0.65725510
60	ERBB3	0.65180785
61	PRKCE	0.63871031
62	WNK3	0.63658976
63	TNK2	0.62316376
64	NLK	0.62084203
65	MAP3K9	0.59235357
66	TAOK3	0.59172361
67	PRKACA	0.58447872
68	EPHA3	0.55934244
69	BMPR1B	0.53948018
70	TTK	0.53357334
71	MATK	0.53044275
72	CDK5	0.51259631
73	CSNK1G3	0.50553722
74	MAPKAPK3	0.50028132
75	PLK4	0.48596387
76	MAP3K6	0.48393598
77	ADRBK2	0.47340003
78	PRKG2	0.45061856
79	ROCK1	0.44010467
80	ERBB4	0.43965447
81	VRK1	0.43763849
82	CSNK1E	0.40227082
83	MAPK8	0.39755510
84	STK11	0.38752067
85	KSR1	0.38028814
86	PRKACB	0.37918064
87	PRKCA	0.36676624
88	ADRBK1	0.36399820
89	CSNK1A1	0.35905506
90	DAPK2	0.35361799
91	PRKCH	0.35058645
92	MAP3K2	0.34837347
93	MAPK10	0.33480175
94	ACVR1B	0.33478715
95	SIK3	0.33050338
96	ABL2	0.31707702
97	RPS6KA3	0.30587526
98	CAMK1	0.30518957
99	CAMK2G	0.28382321
100	CSNK2A1	0.27689835

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	4.62015863
2	Phototransduction_Homo sapiens_hsa04744	3.79433170
3	Cardiac muscle contraction_Homo sapiens_hsa04260	2.70597833
4	Morphine addiction_Homo sapiens_hsa05032	2.67214630
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.64109985
6	Circadian entrainment_Homo sapiens_hsa04713	2.54482229
7	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.28460112
8	GABAergic synapse_Homo sapiens_hsa04727	2.18440941
9	Parkinsons disease_Homo sapiens_hsa05012	1.99261268
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.80918440
11	Glutamatergic synapse_Homo sapiens_hsa04724	1.79306176
12	Olfactory transduction_Homo sapiens_hsa04740	1.74158496
13	Homologous recombination_Homo sapiens_hsa03440	1.72890789
14	Huntingtons disease_Homo sapiens_hsa05016	1.62841038
15	Steroid biosynthesis_Homo sapiens_hsa00100	1.62823615
16	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.55444217
17	Glutathione metabolism_Homo sapiens_hsa00480	1.53711221
18	Protein export_Homo sapiens_hsa03060	1.52985967
19	Collecting duct acid secretion_Homo sapiens_hsa04966	1.47273828
20	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.37634327
21	Alzheimers disease_Homo sapiens_hsa05010	1.37488181
22	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.37241355
23	Selenocompound metabolism_Homo sapiens_hsa00450	1.36482275
24	Dilated cardiomyopathy_Homo sapiens_hsa05414	1.34018944
25	Taste transduction_Homo sapiens_hsa04742	1.32721141
26	Linoleic acid metabolism_Homo sapiens_hsa00591	1.32689257
27	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.29755989
28	Salivary secretion_Homo sapiens_hsa04970	1.29533612
29	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.28106499
30	Insulin secretion_Homo sapiens_hsa04911	1.23019158
31	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.22565615
32	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.20624139
33	Long-term depression_Homo sapiens_hsa04730	1.19552088
34	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.19015686
35	Serotonergic synapse_Homo sapiens_hsa04726	1.18763699
36	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.18533089
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.18348850
38	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.17245487
39	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.12878801
40	Cholinergic synapse_Homo sapiens_hsa04725	1.12675941
41	Dopaminergic synapse_Homo sapiens_hsa04728	1.11681022
42	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	1.10121911
43	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.09887123
44	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.07845358
45	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.07536047
46	Basal cell carcinoma_Homo sapiens_hsa05217	1.05434321
47	Calcium signaling pathway_Homo sapiens_hsa04020	1.03641434
48	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.03600064
49	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.01930634
50	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.01595106
51	Cocaine addiction_Homo sapiens_hsa05030	0.95858956
52	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.94180612
53	Gastric acid secretion_Homo sapiens_hsa04971	0.91792565
54	Circadian rhythm_Homo sapiens_hsa04710	0.90432581
55	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.89199488
56	RNA polymerase_Homo sapiens_hsa03020	0.87240758
57	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.86463424
58	cAMP signaling pathway_Homo sapiens_hsa04024	0.85718436
59	Axon guidance_Homo sapiens_hsa04360	0.81736294
60	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.81178105
61	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.80710148
62	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.79904656
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.77875221
64	Peroxisome_Homo sapiens_hsa04146	0.77243126
65	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75126631
66	Melanogenesis_Homo sapiens_hsa04916	0.72621457
67	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.72380988
68	Basal transcription factors_Homo sapiens_hsa03022	0.71470740
69	Gap junction_Homo sapiens_hsa04540	0.70164405
70	Spliceosome_Homo sapiens_hsa03040	0.69327543
71	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.69154523
72	Amphetamine addiction_Homo sapiens_hsa05031	0.67668274
73	Wnt signaling pathway_Homo sapiens_hsa04310	0.65749664
74	Estrogen signaling pathway_Homo sapiens_hsa04915	0.63277903
75	Tryptophan metabolism_Homo sapiens_hsa00380	0.62521754
76	Glycerolipid metabolism_Homo sapiens_hsa00561	0.61729953
77	Retinol metabolism_Homo sapiens_hsa00830	0.61302850
78	MAPK signaling pathway_Homo sapiens_hsa04010	0.57611805
79	Bile secretion_Homo sapiens_hsa04976	0.55568299
80	Pancreatic secretion_Homo sapiens_hsa04972	0.54465977
81	Rap1 signaling pathway_Homo sapiens_hsa04015	0.53235232
82	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.53153450
83	Fatty acid elongation_Homo sapiens_hsa00062	0.53056881
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.52646476
85	Renin secretion_Homo sapiens_hsa04924	0.51718238
86	Oocyte meiosis_Homo sapiens_hsa04114	0.50781749
87	PPAR signaling pathway_Homo sapiens_hsa03320	0.47977208
88	Ras signaling pathway_Homo sapiens_hsa04014	0.47528529
89	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.46941452
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.46185131
91	Hippo signaling pathway_Homo sapiens_hsa04390	0.45887754
92	One carbon pool by folate_Homo sapiens_hsa00670	0.45703160
93	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.44837034
94	Ether lipid metabolism_Homo sapiens_hsa00565	0.43455512
95	Melanoma_Homo sapiens_hsa05218	0.42170510
96	Butanoate metabolism_Homo sapiens_hsa00650	0.41793685
97	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.40250139
98	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40194172
99	mRNA surveillance pathway_Homo sapiens_hsa03015	0.39391334
100	GnRH signaling pathway_Homo sapiens_hsa04912	0.38226243

MFAP1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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