MFAP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.21973083
2cell proliferation involved in metanephros development (GO:0072203)4.85336274
3outer ear morphogenesis (GO:0042473)4.73460807
4bone trabecula formation (GO:0060346)4.69532675
5proximal/distal pattern formation (GO:0009954)4.63800219
6establishment of integrated proviral latency (GO:0075713)4.46339307
7mesenchymal cell differentiation involved in renal system development (GO:2001012)4.44029259
8mesenchymal cell differentiation involved in kidney development (GO:0072161)4.44029259
9regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)4.32500466
10planar cell polarity pathway involved in neural tube closure (GO:0090179)4.21298767
11cell proliferation involved in kidney development (GO:0072111)4.18659466
12embryonic skeletal joint morphogenesis (GO:0060272)4.07364108
13regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.07115118
14lateral sprouting from an epithelium (GO:0060601)4.04730825
15mesenchyme morphogenesis (GO:0072132)4.03707804
16chondrocyte proliferation (GO:0035988)4.02094014
17metanephric mesenchyme development (GO:0072075)3.95116906
18protein heterotrimerization (GO:0070208)3.90747332
19kidney mesenchyme development (GO:0072074)3.89583634
20chromatin remodeling at centromere (GO:0031055)3.88333299
21G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.87435515
22collagen fibril organization (GO:0030199)3.83225214
23regulation of non-canonical Wnt signaling pathway (GO:2000050)3.71930142
24endocardial cushion morphogenesis (GO:0003203)3.71458993
25establishment of viral latency (GO:0019043)3.71138917
26mesenchymal cell proliferation (GO:0010463)3.69376863
27neuron projection extension involved in neuron projection guidance (GO:1902284)3.68209388
28axon extension involved in axon guidance (GO:0048846)3.68209388
29CENP-A containing nucleosome assembly (GO:0034080)3.65674519
30cell differentiation involved in metanephros development (GO:0072202)3.65600157
31extracellular fibril organization (GO:0043206)3.63050301
32chaperone-mediated protein transport (GO:0072321)3.61506621
33establishment of protein localization to mitochondrial membrane (GO:0090151)3.57835977
34craniofacial suture morphogenesis (GO:0097094)3.51924338
35proteasome assembly (GO:0043248)3.49453644
36respiratory tube development (GO:0030323)3.47289534
37glomerulus development (GO:0032835)3.46734717
38sequestering of extracellular ligand from receptor (GO:0035581)3.46666711
39metanephros development (GO:0001656)3.38942484
40L-serine metabolic process (GO:0006563)3.37672766
41cell migration involved in heart development (GO:0060973)3.36916414
42negative regulation of axon extension involved in axon guidance (GO:0048843)3.35181463
43cochlea morphogenesis (GO:0090103)3.30558197
44mesonephros development (GO:0001823)3.29727658
45nephron tubule morphogenesis (GO:0072078)3.23902535
46nephron epithelium morphogenesis (GO:0072088)3.23902535
47mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23579942
48notochord development (GO:0030903)3.23255073
49negative regulation of chondrocyte differentiation (GO:0032331)3.19783060
50gonadal mesoderm development (GO:0007506)3.17416777
51ribosomal small subunit assembly (GO:0000028)3.16972353
52positive regulation of epithelial to mesenchymal transition (GO:0010718)3.16756666
53heterochromatin organization (GO:0070828)3.16454950
54positive regulation of gastrulation (GO:2000543)3.13707605
55regulation of organ formation (GO:0003156)3.11935207
56epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.11785779
57embryonic forelimb morphogenesis (GO:0035115)3.10243652
58mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.08937109
59convergent extension (GO:0060026)3.08136841
60organ induction (GO:0001759)3.08053148
61mesenchyme development (GO:0060485)3.07323576
62histone exchange (GO:0043486)3.06951212
63lung vasculature development (GO:0060426)3.03433065
64branching involved in ureteric bud morphogenesis (GO:0001658)3.03427723
65pattern specification involved in kidney development (GO:0061004)3.03024825
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02687704
67midgut development (GO:0007494)3.02032599
68ventricular cardiac muscle cell development (GO:0055015)3.01952666
69forelimb morphogenesis (GO:0035136)3.01405975
70fibril organization (GO:0097435)3.00691759
71positive regulation of cartilage development (GO:0061036)3.00079515
72embryonic digit morphogenesis (GO:0042733)2.99958818
73lung-associated mesenchyme development (GO:0060484)2.98046593
74DNA damage response, detection of DNA damage (GO:0042769)2.97552007
75cell differentiation involved in kidney development (GO:0061005)2.96178121
76Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.94772455
77regulation of mitochondrial translation (GO:0070129)2.94737969
78regulation of establishment of planar polarity (GO:0090175)2.91640073
79hindlimb morphogenesis (GO:0035137)2.91200789
80positive regulation of smoothened signaling pathway (GO:0045880)2.90882670
81regulation of cell fate specification (GO:0042659)2.90366414
82negative regulation of axon guidance (GO:1902668)2.90311680
83DNA replication-independent nucleosome organization (GO:0034724)2.90301484
84DNA replication-independent nucleosome assembly (GO:0006336)2.90301484
85regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.87178675
86negative regulation of stem cell proliferation (GO:2000647)2.85696875
87neural crest cell development (GO:0014032)2.85038722
88renal tubule morphogenesis (GO:0061333)2.84850127
89mesenchymal-epithelial cell signaling (GO:0060638)2.83494433
90regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.81966154
91embryonic cranial skeleton morphogenesis (GO:0048701)2.81889952
92middle ear morphogenesis (GO:0042474)2.81694819
93mesenchymal cell development (GO:0014031)2.81686730
94negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.80997794
95negative regulation of ligase activity (GO:0051352)2.80997794
96embryonic digestive tract morphogenesis (GO:0048557)2.80666543
97extracellular regulation of signal transduction (GO:1900115)2.80238811
98extracellular negative regulation of signal transduction (GO:1900116)2.80238811
99negative regulation of cartilage development (GO:0061037)2.79715593
100DNA strand elongation involved in DNA replication (GO:0006271)2.79423992
101body morphogenesis (GO:0010171)2.78196544
102artery development (GO:0060840)2.78098866
103embryonic skeletal system development (GO:0048706)2.77928857
104outflow tract septum morphogenesis (GO:0003148)2.77608483
105cullin deneddylation (GO:0010388)2.77494303
106negative regulation of androgen receptor signaling pathway (GO:0060766)2.75312572
107female gonad development (GO:0008585)2.74613656
108cranial suture morphogenesis (GO:0060363)2.74165190
109head development (GO:0060322)2.72742955
110protein neddylation (GO:0045116)2.72462280
111embryonic hindlimb morphogenesis (GO:0035116)2.70780156
112negative regulation of embryonic development (GO:0045992)2.70776061
113embryonic skeletal system morphogenesis (GO:0048704)2.70735687
114mesenchymal cell differentiation (GO:0048762)2.70541056
115non-canonical Wnt signaling pathway (GO:0035567)2.70144252
116positive regulation of chondrocyte differentiation (GO:0032332)2.69177296
117cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.68783070
118positive regulation of stem cell differentiation (GO:2000738)2.68556340
119ureteric bud development (GO:0001657)2.68333789
120embryonic limb morphogenesis (GO:0030326)2.67024274
121embryonic appendage morphogenesis (GO:0035113)2.67024274
122mesonephric tubule development (GO:0072164)2.66677608
123cell proliferation in forebrain (GO:0021846)2.66444576
124DNA strand elongation (GO:0022616)2.66193499
125energy coupled proton transport, down electrochemical gradient (GO:0015985)2.65850254
126ATP synthesis coupled proton transport (GO:0015986)2.65850254
127embryonic digestive tract development (GO:0048566)2.64709294
128negative regulation of catenin import into nucleus (GO:0035414)2.64153437
129protein deneddylation (GO:0000338)2.63782676
130telomere maintenance via semi-conservative replication (GO:0032201)2.63602415
131anatomical structure regression (GO:0060033)2.62623610
132termination of RNA polymerase III transcription (GO:0006386)2.62206009
133transcription elongation from RNA polymerase III promoter (GO:0006385)2.62206009
134glomerular basement membrane development (GO:0032836)2.62137241
135uterus development (GO:0060065)2.61857369
136anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.60599879
137regulation of gastrulation (GO:0010470)2.60232327
138regulation of cardioblast differentiation (GO:0051890)2.59636233
139positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.59260051
140positive regulation of SMAD protein import into nucleus (GO:0060391)2.58915676
141spliceosomal snRNP assembly (GO:0000387)2.54973924
142mitotic metaphase plate congression (GO:0007080)2.48393338
143protein localization to kinetochore (GO:0034501)2.46389825
144DNA ligation (GO:0006266)2.45207813
145DNA replication checkpoint (GO:0000076)2.45175653
146negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.42778609
147negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.42778609
148negative regulation of mitotic sister chromatid segregation (GO:0033048)2.42778609
149negative regulation of mitotic sister chromatid separation (GO:2000816)2.42778609
150negative regulation of sister chromatid segregation (GO:0033046)2.42778609
151regulation of helicase activity (GO:0051095)2.41726724
152regulation of cell fate commitment (GO:0010453)2.41458598
153nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.40300654
154endothelial cell morphogenesis (GO:0001886)2.38674582
155response to X-ray (GO:0010165)2.37994524
156purine nucleobase biosynthetic process (GO:0009113)2.37312161
157ribosomal large subunit biogenesis (GO:0042273)2.37205794
158histone arginine methylation (GO:0034969)2.36817166
159negative regulation of chromosome segregation (GO:0051985)2.36514290
160kinetochore assembly (GO:0051382)2.36037566
161IMP biosynthetic process (GO:0006188)2.35625236
162DNA strand renaturation (GO:0000733)2.35250572
163negative regulation of cell fate specification (GO:0009996)2.34507735
164spindle checkpoint (GO:0031577)2.33689421
165base-excision repair (GO:0006284)2.33513189
166regulation of gene silencing by RNA (GO:0060966)2.32907325
167regulation of posttranscriptional gene silencing (GO:0060147)2.32907325
168regulation of gene silencing by miRNA (GO:0060964)2.32907325
169exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.32705747
170anterior/posterior axis specification, embryo (GO:0008595)2.32444232
171SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.31968605
172generation of neurons (GO:0048699)2.31608270
173regulation of mitotic spindle checkpoint (GO:1903504)2.31300910
174regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.31300910
175mitotic spindle checkpoint (GO:0071174)2.30573740
176regulation of cellular amino acid metabolic process (GO:0006521)2.29829050
177translational termination (GO:0006415)2.29352576
178protein maturation by protein folding (GO:0022417)2.29093007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.06522297
2E2F7_22180533_ChIP-Seq_HELA_Human4.66792608
3RBPJ_22232070_ChIP-Seq_NCS_Mouse4.29536235
4TP63_19390658_ChIP-ChIP_HaCaT_Human4.25792583
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.94772713
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.26821292
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.20692922
8EED_16625203_ChIP-ChIP_MESCs_Mouse3.01919982
9PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.93176596
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.88895284
11POU5F1_16153702_ChIP-ChIP_HESCs_Human2.88062098
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.83522680
13CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.69679177
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.64436349
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.60543313
16CBX2_27304074_Chip-Seq_ESCs_Mouse2.54781933
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52919411
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.44807209
19POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42770290
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.41739157
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.36741441
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.35941880
23MYC_18358816_ChIP-ChIP_MESCs_Mouse2.32813426
24MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29787111
25E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.28733599
26GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27890195
27EZH2_18974828_ChIP-Seq_MESCs_Mouse2.24848441
28RNF2_18974828_ChIP-Seq_MESCs_Mouse2.24848441
29ETS1_20019798_ChIP-Seq_JURKAT_Human2.19894514
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.19282855
31SALL1_21062744_ChIP-ChIP_HESCs_Human2.18399707
32E2F1_18555785_ChIP-Seq_MESCs_Mouse2.17980696
33TP53_20018659_ChIP-ChIP_R1E_Mouse2.12302283
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06860887
35* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.05875936
36FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.01468171
37KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.95632828
38KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.95632828
39KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.95632828
40ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.94593865
41DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.94427819
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.93748227
43JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92309225
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.88940839
45NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85921254
46ELK1_19687146_ChIP-ChIP_HELA_Human1.85915249
47CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.84696492
48SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.80612948
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.78149939
50SOX2_18555785_ChIP-Seq_MESCs_Mouse1.77910811
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.77907876
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77579222
53E2F4_17652178_ChIP-ChIP_JURKAT_Human1.77521182
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.76685330
55RNF2_27304074_Chip-Seq_ESCs_Mouse1.75057247
56JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73900968
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.69557103
58KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.66855221
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66768841
60AR_21909140_ChIP-Seq_LNCAP_Human1.66221607
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62869464
62ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61989861
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.61281105
64MYC_18940864_ChIP-ChIP_HL60_Human1.59635130
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.59218044
66CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.58527375
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53672528
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47282526
69MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.46336916
70GABP_19822575_ChIP-Seq_HepG2_Human1.44214583
71HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.43019078
72RING1B_27294783_Chip-Seq_NPCs_Mouse1.41515761
73SRF_21415370_ChIP-Seq_HL-1_Mouse1.40921154
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.40589423
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.38754013
76FOXP3_21729870_ChIP-Seq_TREG_Human1.37153074
77MYCN_18555785_ChIP-Seq_MESCs_Mouse1.36567859
78BRD4_25478319_ChIP-Seq_HGPS_Human1.34780769
79ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.32410366
80CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.32370890
81DCP1A_22483619_ChIP-Seq_HELA_Human1.32015880
82NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.31194468
83* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30868407
84RARG_19884340_ChIP-ChIP_MEFs_Mouse1.30728872
85MYC_18555785_ChIP-Seq_MESCs_Mouse1.30190725
86CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.28737269
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.28447964
88CLOCK_20551151_ChIP-Seq_293T_Human1.27117668
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.27088029
90EZH2_27294783_Chip-Seq_ESCs_Mouse1.26147546
91FUS_26573619_Chip-Seq_HEK293_Human1.25265367
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.23932767
93RING1B_27294783_Chip-Seq_ESCs_Mouse1.23453003
94FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.22898250
95YY1_21170310_ChIP-Seq_MESCs_Mouse1.21872325
96DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.21834910
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.20423433
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20409264
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19166995
100NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.18465059
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.17415496
102TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.17077952
103KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16957340
104PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16425491
105RNF2_27304074_Chip-Seq_NSC_Mouse1.16158369
106POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.16056494
107MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13169623
108TCF3_18692474_ChIP-Seq_MESCs_Mouse1.12604685
109FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11150076
110VDR_23849224_ChIP-Seq_CD4+_Human1.11122899
111EWS_26573619_Chip-Seq_HEK293_Human1.10376967
112ZNF274_21170338_ChIP-Seq_K562_Hela1.10319121
113XRN2_22483619_ChIP-Seq_HELA_Human1.09898603
114* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.06107670
115NANOG_21062744_ChIP-ChIP_HESCs_Human1.05469792
116SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01842281
117ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00836866
118NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00160298
119TP53_18474530_ChIP-ChIP_U2OS_Human0.98660507
120SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98394115
121PADI4_21655091_ChIP-ChIP_MCF-7_Human0.98205747
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.97456206
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.95926898
124EOMES_21245162_ChIP-Seq_HESCs_Human0.94967209
125MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.94755125
126POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.94276512
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.93196865
128POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92911862
129NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92838799
130* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91803655
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.90124939
132* CJUN_26792858_Chip-Seq_BT549_Human0.90088247
133GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88232916
134PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.88139469
135TTF2_22483619_ChIP-Seq_HELA_Human0.85546805
136TP63_17297297_ChIP-ChIP_HaCaT_Human0.85391350
137OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85216047
138YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.84800802
139MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84328757
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.84133659
141CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.83776078
142CIITA_25753668_ChIP-Seq_RAJI_Human0.83658842
143ZFX_18555785_ChIP-Seq_MESCs_Mouse0.83490187
144E2F1_21310950_ChIP-Seq_MCF-7_Human0.83388373
145P300_19829295_ChIP-Seq_ESCs_Human0.82998320
146TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.82970845
147IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82904776
148SOX17_20123909_ChIP-Seq_XEN_Mouse0.80857560
149SOX3_22085726_ChIP-Seq_NPCs_Mouse0.80820469
150PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.80615340
151PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79687381
152TCF3_18692474_ChIP-Seq_MEFs_Mouse0.79673451
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79451774
154SOX9_26525672_Chip-Seq_HEART_Mouse0.79371501

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.18656365
2MP0008438_abnormal_cutaneous_collagen4.61072119
3MP0010030_abnormal_orbit_morphology3.55278667
4MP0003122_maternal_imprinting3.34772338
5MP0003123_paternal_imprinting3.31875223
6MP0005275_abnormal_skin_tensile3.29276490
7MP0003385_abnormal_body_wall2.87349341
8MP0003942_abnormal_urinary_system2.84208472
9MP0002249_abnormal_larynx_morphology2.70388466
10MP0009250_abnormal_appendicular_skeleto2.50748188
11MP0003121_genomic_imprinting2.45642375
12MP0009053_abnormal_anal_canal2.38930287
13MP0000049_abnormal_middle_ear2.36072264
14MP0000566_synostosis2.19172266
15MP0002282_abnormal_trachea_morphology2.17914801
16MP0000534_abnormal_ureter_morphology2.17280399
17MP0002938_white_spotting2.09866905
18MP0005508_abnormal_skeleton_morphology2.08620454
19MP0003115_abnormal_respiratory_system2.07744763
20MP0002254_reproductive_system_inflammat2.06783800
21MP0004272_abnormal_basement_membrane2.06028455
22MP0002932_abnormal_joint_morphology1.97584808
23MP0000537_abnormal_urethra_morphology1.87452915
24MP0006054_spinal_hemorrhage1.86475320
25MP0003705_abnormal_hypodermis_morpholog1.83847016
26MP0003755_abnormal_palate_morphology1.76703760
27MP0001958_emphysema1.72436975
28MP0003693_abnormal_embryo_hatching1.67517465
29MP0003937_abnormal_limbs/digits/tail_de1.65632859
30MP0003279_aneurysm1.63784685
31MP0003938_abnormal_ear_development1.57250067
32MP0000678_abnormal_parathyroid_gland1.56246393
33MP0004133_heterotaxia1.55408095
34MP0003315_abnormal_perineum_morphology1.55184360
35MP0002108_abnormal_muscle_morphology1.54699970
36MP0008058_abnormal_DNA_repair1.54516383
37MP0005248_abnormal_Harderian_gland1.52247226
38MP0002116_abnormal_craniofacial_bone1.48038881
39MP0001879_abnormal_lymphatic_vessel1.47576328
40MP0000579_abnormal_nail_morphology1.46123256
41MP0000428_abnormal_craniofacial_morphol1.42479179
42MP0003935_abnormal_craniofacial_develop1.41604233
43MP0005499_abnormal_olfactory_system1.40927018
44MP0005394_taste/olfaction_phenotype1.40927018
45MP0010368_abnormal_lymphatic_system1.39408860
46MP0002109_abnormal_limb_morphology1.34703440
47MP0009384_cardiac_valve_regurgitation1.33837471
48MP0003119_abnormal_digestive_system1.32919798
49MP0002653_abnormal_ependyma_morphology1.29345830
50MP0002295_abnormal_pulmonary_circulatio1.28460855
51MP0010094_abnormal_chromosome_stability1.28372160
52MP0003787_abnormal_imprinting1.26602977
53MP0002233_abnormal_nose_morphology1.25741157
54MP0000163_abnormal_cartilage_morphology1.24022308
55MP0002114_abnormal_axial_skeleton1.21315708
56MP0004134_abnormal_chest_morphology1.21029083
57MP0005257_abnormal_intraocular_pressure1.20665587
58MP0002115_abnormal_skeleton_extremities1.16983746
59MP0003136_yellow_coat_color1.15707091
60MP0000767_abnormal_smooth_muscle1.15217771
61MP0003941_abnormal_skin_development1.14034067
62MP0003567_abnormal_fetal_cardiomyocyte1.13894780
63MP0002111_abnormal_tail_morphology1.13503703
64MP0000516_abnormal_urinary_system1.12230345
65MP0005367_renal/urinary_system_phenotyp1.12230345
66MP0001286_abnormal_eye_development1.11487535
67MP0008007_abnormal_cellular_replicative1.11449676
68MP0000762_abnormal_tongue_morphology1.08558519
69MP0003718_maternal_effect1.07472203
70MP0000432_abnormal_head_morphology1.06702270
71MP0002177_abnormal_outer_ear1.04913560
72MP0009379_abnormal_foot_pigmentation1.04448773
73MP0002092_abnormal_eye_morphology1.03830123
74MP0002084_abnormal_developmental_patter1.03473695
75MP0001542_abnormal_bone_strength1.03425215
76MP0008932_abnormal_embryonic_tissue1.02543278
77MP0000751_myopathy1.01007248
78MP0003890_abnormal_embryonic-extraembry1.00992363
79MP0001270_distended_abdomen0.98726635
80MP0002697_abnormal_eye_size0.98118714
81MP0002102_abnormal_ear_morphology0.97110980
82MP0001529_abnormal_vocalization0.96400211
83MP0006072_abnormal_retinal_apoptosis0.96299275
84MP0002113_abnormal_skeleton_development0.95866225
85MP0005197_abnormal_uvea_morphology0.95090685
86MP0003186_abnormal_redox_activity0.94447582
87MP0002085_abnormal_embryonic_tissue0.93625231
88MP0003077_abnormal_cell_cycle0.92132762
89MP0009672_abnormal_birth_weight0.91962529
90MP0008877_abnormal_DNA_methylation0.91772975
91MP0001293_anophthalmia0.91708884
92MP0001849_ear_inflammation0.90781445
93MP0009697_abnormal_copulation0.90701556
94MP0002060_abnormal_skin_morphology0.89727773
95MP0001243_abnormal_dermal_layer0.89670674
96MP0001175_abnormal_lung_morphology0.87665821
97MP0008789_abnormal_olfactory_epithelium0.86435402
98MP0005623_abnormal_meninges_morphology0.85447914
99MP0006292_abnormal_olfactory_placode0.84529905
100MP0002751_abnormal_autonomic_nervous0.84143731
101MP0004197_abnormal_fetal_growth/weight/0.83907150
102MP0000778_abnormal_nervous_system0.83229045
103MP0005391_vision/eye_phenotype0.82751416
104MP0009703_decreased_birth_body0.81762311
105MP0002896_abnormal_bone_mineralization0.81683523
106MP0005171_absent_coat_pigmentation0.80992770
107MP0000733_abnormal_muscle_development0.79770538
108MP0002127_abnormal_cardiovascular_syste0.78693893
109MP0001340_abnormal_eyelid_morphology0.78660592
110MP0001346_abnormal_lacrimal_gland0.77851171
111MP0003111_abnormal_nucleus_morphology0.76023720
112MP0002081_perinatal_lethality0.75849491
113MP0003861_abnormal_nervous_system0.74917658
114MP0002234_abnormal_pharynx_morphology0.73447546
115MP0005390_skeleton_phenotype0.73443382
116MP0001119_abnormal_female_reproductive0.72603862
117MP0003943_abnormal_hepatobiliary_system0.72127813
118MP0005023_abnormal_wound_healing0.69495071
119MP0000462_abnormal_digestive_system0.68761174
120MP0004957_abnormal_blastocyst_morpholog0.68022768
121MP0003878_abnormal_ear_physiology0.67074536
122MP0005377_hearing/vestibular/ear_phenot0.67074536
123MP0001697_abnormal_embryo_size0.65875396
124MP0000026_abnormal_inner_ear0.65824858
125MP0002925_abnormal_cardiovascular_devel0.65804214
126MP0002160_abnormal_reproductive_system0.65620854
127MP0008057_abnormal_DNA_replication0.65357890
128MP0001299_abnormal_eye_distance/0.64231445
129MP0001177_atelectasis0.63942148
130MP0003283_abnormal_digestive_organ0.63817221

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.62562373
2Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.58173828
3Short 4th metacarpal (HP:0010044)4.58173828
4Hepatoblastoma (HP:0002884)4.17025496
5Renal duplication (HP:0000075)3.97085943
6Shallow orbits (HP:0000586)3.54731776
7Abnormality of the 4th metacarpal (HP:0010012)3.49269713
8Premature rupture of membranes (HP:0001788)3.42327196
9Bladder diverticulum (HP:0000015)3.41592317
10Diastasis recti (HP:0001540)3.32992545
11Broad metatarsal (HP:0001783)3.25975269
12Soft skin (HP:0000977)3.17803687
13Septo-optic dysplasia (HP:0100842)3.13200927
14Abnormality of dentin (HP:0010299)3.05449394
15Abnormality of the phalanges of the hallux (HP:0010057)3.04016072
16Abnormality of the labia minora (HP:0012880)3.00098977
17Broad toe (HP:0001837)2.94666434
18Embryonal renal neoplasm (HP:0011794)2.91659132
19Ankle contracture (HP:0006466)2.87397014
20Morphological abnormality of the middle ear (HP:0008609)2.86248435
21Aortic dissection (HP:0002647)2.84816985
22Colon cancer (HP:0003003)2.84043116
23Follicular hyperkeratosis (HP:0007502)2.81287172
24Nephroblastoma (Wilms tumor) (HP:0002667)2.72200488
25Coronal craniosynostosis (HP:0004440)2.69043175
26Neonatal short-limb short stature (HP:0008921)2.67754094
27Abnormality of the aortic arch (HP:0012303)2.66630216
28Pulmonary artery stenosis (HP:0004415)2.63972705
29Abnormality of the parietal bone (HP:0002696)2.62094188
30Midline defect of the nose (HP:0004122)2.61186199
31Reticulocytopenia (HP:0001896)2.52562171
32Wide anterior fontanel (HP:0000260)2.46470173
33Biconcave vertebral bodies (HP:0004586)2.44747658
34Anophthalmia (HP:0000528)2.42217888
35Partial duplication of thumb phalanx (HP:0009944)2.40995745
36Mesomelia (HP:0003027)2.38971366
37Hypoplastic pelvis (HP:0008839)2.37422152
38Asymmetry of the thorax (HP:0001555)2.35263277
39Abnormality of the distal phalanx of the thumb (HP:0009617)2.32251778
40Calcaneovalgus deformity (HP:0001848)2.31636441
41Stenosis of the external auditory canal (HP:0000402)2.31080615
42Short middle phalanx of the 5th finger (HP:0004220)2.27887544
43Atrophic scars (HP:0001075)2.25191740
44Bilateral microphthalmos (HP:0007633)2.22893594
45Type 1 muscle fiber predominance (HP:0003803)2.22531027
46Abnormality of the phalanges of the 2nd finger (HP:0009541)2.21394318
47Preaxial foot polydactyly (HP:0001841)2.18022716
48Hypoplastic left heart (HP:0004383)2.15647834
49Broad long bones (HP:0005622)2.14523194
50Deformed tarsal bones (HP:0008119)2.13632665
51Maternal diabetes (HP:0009800)2.11584757
52Broad thumb (HP:0011304)2.10064111
53Blue sclerae (HP:0000592)2.09331768
54Vitreoretinal degeneration (HP:0000655)2.08694363
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.08103109
56Absent septum pellucidum (HP:0001331)2.04601137
57Deviation of the hallux (HP:0010051)2.03395954
58Irregular epiphyses (HP:0010582)2.03254579
59Partial duplication of the phalanx of hand (HP:0009999)2.02864048
60True hermaphroditism (HP:0010459)2.02814149
61Aplasia/Hypoplasia of the sacrum (HP:0008517)2.01391970
62Short 5th finger (HP:0009237)2.00689313
63Broad hallux (HP:0010055)2.00510059
64Camptodactyly of toe (HP:0001836)1.99922837
65Bell-shaped thorax (HP:0001591)1.99788579
66Wormian bones (HP:0002645)1.98709302
67Broad phalanx (HP:0006009)1.97864014
68Acute necrotizing encephalopathy (HP:0006965)1.97678747
69Broad finger (HP:0001500)1.96917956
70Broad phalanges of the hand (HP:0009768)1.96606960
71Facial cleft (HP:0002006)1.96191253
72Renal hypoplasia (HP:0000089)1.96069858
73Abnormal lung lobation (HP:0002101)1.95610322
74Spinal cord lesions (HP:0100561)1.95516420
75Syringomyelia (HP:0003396)1.95516420
76Aplasia/Hypoplasia of the breasts (HP:0010311)1.95321059
77Aortic aneurysm (HP:0004942)1.93132583
78Broad palm (HP:0001169)1.93062923
79Joint laxity (HP:0001388)1.92986717
80Absent eyelashes (HP:0000561)1.92453843
81Patent foramen ovale (HP:0001655)1.91014769
82Single umbilical artery (HP:0001195)1.90632043
83Abnormality of the fetal cardiovascular system (HP:0010948)1.90632043
84Abnormal umbilical cord blood vessels (HP:0011403)1.90632043
85Vascular tortuosity (HP:0004948)1.89124801
86Cutaneous finger syndactyly (HP:0010554)1.89044788
87Abnormality of the middle phalanges of the toes (HP:0010183)1.88655330
88Duplication of thumb phalanx (HP:0009942)1.88637023
89Turricephaly (HP:0000262)1.88413737
90Occipital encephalocele (HP:0002085)1.88095846
91Flared iliac wings (HP:0002869)1.87906954
92Overgrowth (HP:0001548)1.87681764
93Microglossia (HP:0000171)1.87650588
94Pancreatic fibrosis (HP:0100732)1.87616979
95Trigonocephaly (HP:0000243)1.87375021
96High anterior hairline (HP:0009890)1.87298544
97Down-sloping shoulders (HP:0200021)1.85630619
98Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85400053
99Abnormality of abdominal situs (HP:0011620)1.85318690
100Abdominal situs inversus (HP:0003363)1.85318690
101Hallux valgus (HP:0001822)1.85175876
102Adrenal hypoplasia (HP:0000835)1.84854755
103Abnormality of the nasolacrimal system (HP:0000614)1.84784815
104Acute encephalopathy (HP:0006846)1.84740510
105Choanal stenosis (HP:0000452)1.83391508
106Supernumerary ribs (HP:0005815)1.82888644
107Fragile skin (HP:0001030)1.82491275
108Renovascular hypertension (HP:0100817)1.82313313
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.82011808
110Absent epiphyses (HP:0010577)1.82011808
111Flat cornea (HP:0007720)1.81265565
112Supernumerary spleens (HP:0009799)1.81180473
113Wrist flexion contracture (HP:0001239)1.81047629
114Triphalangeal thumb (HP:0001199)1.80795404
115Anencephaly (HP:0002323)1.80732136
116Preaxial hand polydactyly (HP:0001177)1.79723966
117Sclerocornea (HP:0000647)1.79190843
118Abnormal number of incisors (HP:0011064)1.78966052
119Arterial tortuosity (HP:0005116)1.78736106
120Short hallux (HP:0010109)1.78074533
121Bifid tongue (HP:0010297)1.77333476
122Delayed cranial suture closure (HP:0000270)1.76855035
123Preauricular pit (HP:0004467)1.76605566
124Periauricular skin pits (HP:0100277)1.76605566
125Natal tooth (HP:0000695)1.76552858
126Meckel diverticulum (HP:0002245)1.75541168
127Cutaneous syndactyly (HP:0012725)1.75215459
128Breast aplasia (HP:0100783)1.74958391
129Selective tooth agenesis (HP:0001592)1.72699439
130Dislocated radial head (HP:0003083)1.72117664
131Abnormality of the radial head (HP:0003995)1.72007758
132Mitral valve prolapse (HP:0001634)1.71635674
133Shawl scrotum (HP:0000049)1.71632352
134Dental crowding (HP:0000678)1.70645783
135Aplasia/Hypoplasia of the hallux (HP:0008362)1.70635019
136Slender build (HP:0001533)1.70362818
137Omphalocele (HP:0001539)1.69691817
138Bowel diverticulosis (HP:0005222)1.69323446
139Inguinal hernia (HP:0000023)1.68718416
140Patellar aplasia (HP:0006443)1.68681071
141Abnormality of the septum pellucidum (HP:0007375)1.68650033
142Dilatation of the ascending aorta (HP:0005111)1.68447057
143Breech presentation (HP:0001623)1.67650216
144Cervical subluxation (HP:0003308)1.67512983
145Aplasia/Hypoplasia of the sternum (HP:0006714)1.67412735
146Hyperextensible skin (HP:0000974)1.66764766
147Abnormal mitochondria in muscle tissue (HP:0008316)1.66208009
148Myelomeningocele (HP:0002475)1.62933393
149Hemivertebrae (HP:0002937)1.61979862
150Mitochondrial inheritance (HP:0001427)1.61307362
151Abnormal number of erythroid precursors (HP:0012131)1.61165269
152Abnormality of the ileum (HP:0001549)1.60487669
153Ectopic kidney (HP:0000086)1.57845097
154Hyperglycinemia (HP:0002154)1.57671087
155Rib fusion (HP:0000902)1.57442878
156Hepatocellular necrosis (HP:0001404)1.57120876
157Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.57020888
158Keratoconus (HP:0000563)1.56215203
159Increased corneal curvature (HP:0100692)1.56215203
160Postaxial foot polydactyly (HP:0001830)1.55236524
161Absent radius (HP:0003974)1.54041586
162Holoprosencephaly (HP:0001360)1.53754736
163Short tibia (HP:0005736)1.53223315
164Broad foot (HP:0001769)1.53044776
165Optic nerve hypoplasia (HP:0000609)1.52402864
166Delayed gross motor development (HP:0002194)1.52176666
167Vaginal atresia (HP:0000148)1.51446044
168Hypoplasia of the capital femoral epiphysis (HP:0003090)1.50754797

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.47563946
2LATS13.62155565
3LATS23.61141283
4EPHB23.27130456
5DDR23.00548786
6STK38L2.90151035
7CDC72.55622615
8ERBB32.42298507
9MKNK12.26749089
10PRKD32.26385656
11BUB12.16300865
12PDGFRA2.15124538
13STK162.10274060
14PBK2.07695819
15TNIK2.05836307
16CDK192.05049709
17DYRK21.96310132
18RPS6KA41.92815734
19EPHA31.85759101
20MYLK1.84687138
21TIE11.84368801
22TAF11.72042444
23MAP3K101.71070018
24MAPK131.70685550
25TGFBR11.70172142
26SRPK11.63377842
27PLK31.60656129
28MKNK21.55017164
29TSSK61.49412284
30BCKDK1.48052997
31CDK81.47995330
32EPHA41.46728140
33DYRK31.44978408
34TRIB31.44144981
35TRIM281.43651337
36CDK71.39615457
37STK31.38781476
38PLK21.36032951
39NEK11.35891755
40PASK1.31833554
41TTK1.25723652
42PLK11.24279498
43NME11.24017352
44WEE11.23203962
45FGFR11.21906650
46NUAK11.21864872
47NME21.20780436
48CSNK1G11.20402276
49KSR11.19675721
50MAP4K21.18961001
51YES11.18470202
52LIMK11.16097466
53AURKB1.15814818
54ILK1.13293255
55BMX1.12261303
56BRSK11.11940374
57BCR1.10870763
58BRAF1.07533382
59BMPR1B1.06476167
60FLT31.05837661
61ZAK1.04138962
62CSNK1G31.03812123
63BRD40.96092140
64KDR0.93457065
65PLK40.93018939
66CHEK20.92584956
67FER0.92021701
68AKT30.90749593
69PTK2B0.89477462
70ATR0.88742714
71CSNK1G20.87700371
72ROCK10.84073845
73PKN10.84058834
74UHMK10.83247091
75NEK90.83163374
76ERBB20.83027795
77AURKA0.81059921
78OBSCN0.79907219
79MAP2K70.79018841
80PRKD20.78069815
81PRKCI0.77158802
82PAK20.71930930
83BRSK20.69191441
84STK240.68264631
85MAP3K40.68204096
86PAK30.66746889
87VRK10.66444005
88MELK0.65698433
89PNCK0.65281141
90INSRR0.64988122
91CHEK10.64974408
92FRK0.64002649
93PAK40.61956346
94MET0.61549759
95BMPR20.58836439
96CDK10.58575281
97TESK20.58374314
98FGFR20.57828174
99TESK10.55930902
100TAOK20.55864689
101MST40.54314728
102STK40.53727259
103ACVR1B0.53272944
104DAPK30.53184291
105SIK30.53014795
106EPHA20.51938493
107CLK10.51175277
108ADRBK10.50420062
109ERBB40.50312083
110CASK0.50083822
111GRK10.49789837
112PTK60.48653893
113ABL20.48083515
114NEK20.47608697
115PTK20.47573859
116NTRK10.47045308
117AKT20.45808284
118CDK20.45593055
119DAPK10.44553275
120WNK30.44549972
121DMPK0.43377096
122PIK3CA0.42380901
123CDK11A0.41658628
124CSNK2A10.41289265
125ROCK20.41225567
126PDGFRB0.40544168
127MAP3K60.39708029
128CDC42BPA0.39412849
129PRKCE0.39128341
130PAK10.38182452
131PRKCG0.37656582
132CDK180.37112473
133CSNK2A20.36681939
134ATM0.36028008
135CDK150.35256875
136MAP3K80.34206204
137DYRK1A0.34133026
138CSNK1A1L0.32593057
139EIF2AK20.32313292
140CAMK40.32073150
141PRPF4B0.31733304

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.05181481
2Hedgehog signaling pathway_Homo sapiens_hsa043403.38383188
3Cell cycle_Homo sapiens_hsa041103.07441958
4Hippo signaling pathway_Homo sapiens_hsa043902.64798098
5Spliceosome_Homo sapiens_hsa030402.63168639
6Base excision repair_Homo sapiens_hsa034102.55190133
7DNA replication_Homo sapiens_hsa030302.53246362
8TGF-beta signaling pathway_Homo sapiens_hsa043502.24663442
9Oxidative phosphorylation_Homo sapiens_hsa001902.23146903
10Mismatch repair_Homo sapiens_hsa034302.20990099
11ECM-receptor interaction_Homo sapiens_hsa045122.20567182
12Parkinsons disease_Homo sapiens_hsa050122.16756879
13Protein digestion and absorption_Homo sapiens_hsa049741.87696872
14Adherens junction_Homo sapiens_hsa045201.86341732
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.85567118
16Wnt signaling pathway_Homo sapiens_hsa043101.81671727
17Notch signaling pathway_Homo sapiens_hsa043301.81200999
18MicroRNAs in cancer_Homo sapiens_hsa052061.81088022
19Huntingtons disease_Homo sapiens_hsa050161.79915895
20Homologous recombination_Homo sapiens_hsa034401.79412258
21RNA transport_Homo sapiens_hsa030131.74672696
22Nucleotide excision repair_Homo sapiens_hsa034201.69601397
23Focal adhesion_Homo sapiens_hsa045101.63911515
24mRNA surveillance pathway_Homo sapiens_hsa030151.63594599
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.61688054
26RNA degradation_Homo sapiens_hsa030181.59282901
27Cysteine and methionine metabolism_Homo sapiens_hsa002701.59225565
28Fatty acid elongation_Homo sapiens_hsa000621.53991813
29Proteoglycans in cancer_Homo sapiens_hsa052051.53845172
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.52594279
31Axon guidance_Homo sapiens_hsa043601.49722677
32Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.48739377
33RNA polymerase_Homo sapiens_hsa030201.48578318
34Basal transcription factors_Homo sapiens_hsa030221.46490530
35Steroid biosynthesis_Homo sapiens_hsa001001.44511242
36Melanogenesis_Homo sapiens_hsa049161.43477046
37Biosynthesis of amino acids_Homo sapiens_hsa012301.42908746
38Propanoate metabolism_Homo sapiens_hsa006401.40457257
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.40025438
40Pyruvate metabolism_Homo sapiens_hsa006201.34279981
41Alzheimers disease_Homo sapiens_hsa050101.33915738
42Pathways in cancer_Homo sapiens_hsa052001.33844188
43Sulfur relay system_Homo sapiens_hsa041221.31824642
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.31235143
45Fanconi anemia pathway_Homo sapiens_hsa034601.27447159
46HTLV-I infection_Homo sapiens_hsa051661.26885761
47Small cell lung cancer_Homo sapiens_hsa052221.26668097
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25981381
49Prostate cancer_Homo sapiens_hsa052151.23928096
50Pyrimidine metabolism_Homo sapiens_hsa002401.23788375
51Colorectal cancer_Homo sapiens_hsa052101.20709542
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.18046153
53Dilated cardiomyopathy_Homo sapiens_hsa054141.17114177
54Endometrial cancer_Homo sapiens_hsa052131.16434673
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.14903489
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14168958
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13034039
58Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.12950813
59Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.12806870
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11964142
61Oocyte meiosis_Homo sapiens_hsa041141.09209939
62Melanoma_Homo sapiens_hsa052181.08483227
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.07643464
64Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06123482
65p53 signaling pathway_Homo sapiens_hsa041151.05105665
66Folate biosynthesis_Homo sapiens_hsa007901.03632327
67Chronic myeloid leukemia_Homo sapiens_hsa052201.01948880
68Arachidonic acid metabolism_Homo sapiens_hsa005901.01635627
69Bladder cancer_Homo sapiens_hsa052190.99155622
70Carbon metabolism_Homo sapiens_hsa012000.96969017
71Cardiac muscle contraction_Homo sapiens_hsa042600.94590841
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.94263600
73Thyroid cancer_Homo sapiens_hsa052160.93261451
74Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.92194642
75Protein export_Homo sapiens_hsa030600.91687301
76Vitamin B6 metabolism_Homo sapiens_hsa007500.90108531
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89562557
78Ovarian steroidogenesis_Homo sapiens_hsa049130.88058728
79Selenocompound metabolism_Homo sapiens_hsa004500.86413500
80Tight junction_Homo sapiens_hsa045300.85493614
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.84377233
82Proteasome_Homo sapiens_hsa030500.82287800
83Pancreatic cancer_Homo sapiens_hsa052120.80782711
84Ribosome_Homo sapiens_hsa030100.80562436
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78670212
86Lysine degradation_Homo sapiens_hsa003100.78157818
87Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.74405299
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.74402539
89Rap1 signaling pathway_Homo sapiens_hsa040150.73861883
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71011383
91Arginine and proline metabolism_Homo sapiens_hsa003300.69280090
92Metabolic pathways_Homo sapiens_hsa011000.68031504
93Amoebiasis_Homo sapiens_hsa051460.67833278
94Viral myocarditis_Homo sapiens_hsa054160.66602590
95One carbon pool by folate_Homo sapiens_hsa006700.66029258
96Non-homologous end-joining_Homo sapiens_hsa034500.63578987
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.62121343
98Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.60908667
99Galactose metabolism_Homo sapiens_hsa000520.60063280
100Purine metabolism_Homo sapiens_hsa002300.59555213
101Linoleic acid metabolism_Homo sapiens_hsa005910.59019622
102Epstein-Barr virus infection_Homo sapiens_hsa051690.58836460
103Glioma_Homo sapiens_hsa052140.56947467
104Viral carcinogenesis_Homo sapiens_hsa052030.56542614
105Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53705531
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.53336970
107Gap junction_Homo sapiens_hsa045400.52881126
108N-Glycan biosynthesis_Homo sapiens_hsa005100.52753161
109Phototransduction_Homo sapiens_hsa047440.50608960
110alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.50172154
111Non-small cell lung cancer_Homo sapiens_hsa052230.48773890
112Renal cell carcinoma_Homo sapiens_hsa052110.46493237
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46460565
114Hepatitis B_Homo sapiens_hsa051610.46292591
115Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44138247
116Herpes simplex infection_Homo sapiens_hsa051680.43886407
117Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43208167
118FoxO signaling pathway_Homo sapiens_hsa040680.40157368
119Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.40063743
120Malaria_Homo sapiens_hsa051440.38244967
121Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37559778
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.37149021
123Fatty acid metabolism_Homo sapiens_hsa012120.36918461
124Alcoholism_Homo sapiens_hsa050340.36721177
125Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36344805
126Vitamin digestion and absorption_Homo sapiens_hsa049770.35815514
127Peroxisome_Homo sapiens_hsa041460.32620697
128Pentose phosphate pathway_Homo sapiens_hsa000300.29730410
129Primary bile acid biosynthesis_Homo sapiens_hsa001200.29291102
130Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28181934
131Glutathione metabolism_Homo sapiens_hsa004800.27295651
132Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.25696258
133Ras signaling pathway_Homo sapiens_hsa040140.25347660
134Fatty acid degradation_Homo sapiens_hsa000710.25005828
135Cyanoamino acid metabolism_Homo sapiens_hsa004600.24983495
136beta-Alanine metabolism_Homo sapiens_hsa004100.23872322
137Sulfur metabolism_Homo sapiens_hsa009200.22704601
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.22601619
139Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22037264
140Longevity regulating pathway - mammal_Homo sapiens_hsa042110.20675739
141Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.20304199
142GnRH signaling pathway_Homo sapiens_hsa049120.20213752
143cGMP-PKG signaling pathway_Homo sapiens_hsa040220.20019469
144Aldosterone synthesis and secretion_Homo sapiens_hsa049250.19610225

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