MFAP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.23787292
2regulation of dendritic spine morphogenesis (GO:0061001)4.64165577
3protein localization to microtubule (GO:0035372)4.39121281
4RNA destabilization (GO:0050779)4.29177583
5metaphase plate congression (GO:0051310)4.27607854
6nuclear pore complex assembly (GO:0051292)4.07102494
7retina vasculature morphogenesis in camera-type eye (GO:0061299)4.04423867
8phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.89759202
9response to pheromone (GO:0019236)3.74330697
10ribosomal small subunit assembly (GO:0000028)3.69324859
11ganglion development (GO:0061548)3.64001715
12NLS-bearing protein import into nucleus (GO:0006607)3.59975476
13COPII vesicle coating (GO:0048208)3.56670894
14positive regulation of dendritic spine morphogenesis (GO:0061003)3.43191236
15establishment of chromosome localization (GO:0051303)3.39747201
16negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.39274204
17fatty acid elongation (GO:0030497)3.38494872
18regulation of transforming growth factor beta2 production (GO:0032909)3.38404558
19phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.36796173
20alpha-linolenic acid metabolic process (GO:0036109)3.35644756
21negative regulation of RNA splicing (GO:0033119)3.35240908
22IMP biosynthetic process (GO:0006188)3.34565983
23cell adhesion mediated by integrin (GO:0033627)3.25587701
24protein deneddylation (GO:0000338)3.24061718
25histone H2A acetylation (GO:0043968)3.16496275
26lymphoid progenitor cell differentiation (GO:0002320)3.15147221
27gastrulation with mouth forming second (GO:0001702)3.14779445
28DNA unwinding involved in DNA replication (GO:0006268)3.13018313
29glycosphingolipid biosynthetic process (GO:0006688)3.11758125
30regulation of dendritic spine development (GO:0060998)3.11733906
31cullin deneddylation (GO:0010388)3.11214056
32DNA strand elongation involved in DNA replication (GO:0006271)3.09856270
33DNA strand elongation (GO:0022616)3.08071934
34regulation of Rap GTPase activity (GO:0032317)3.07987807
35pore complex assembly (GO:0046931)3.02826215
36dosage compensation (GO:0007549)3.00562138
37positive regulation of Rap GTPase activity (GO:0032854)2.99865244
38histone mRNA metabolic process (GO:0008334)2.98487821
39axonal fasciculation (GO:0007413)2.96952267
40intra-S DNA damage checkpoint (GO:0031573)2.93213628
41ganglioside metabolic process (GO:0001573)2.92777895
42UDP-N-acetylglucosamine metabolic process (GO:0006047)2.92192881
43substrate-independent telencephalic tangential migration (GO:0021826)2.90932293
44substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.90932293
45IMP metabolic process (GO:0046040)2.90859847
46vesicle coating (GO:0006901)2.90840837
47neuron projection extension involved in neuron projection guidance (GO:1902284)2.89437856
48axon extension involved in axon guidance (GO:0048846)2.89437856
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.88583908
50ephrin receptor signaling pathway (GO:0048013)2.88541200
51spliceosomal snRNP assembly (GO:0000387)2.87398553
52definitive hemopoiesis (GO:0060216)2.86633965
53telomere maintenance via semi-conservative replication (GO:0032201)2.86365903
54cellular response to gamma radiation (GO:0071480)2.86074594
55mitotic spindle organization (GO:0007052)2.83135948
56spindle checkpoint (GO:0031577)2.80058530
57myelin assembly (GO:0032288)2.79403836
58CENP-A containing nucleosome assembly (GO:0034080)2.78132799
59zinc ion transport (GO:0006829)2.77186034
60Golgi transport vesicle coating (GO:0048200)2.75712029
61COPI coating of Golgi vesicle (GO:0048205)2.75712029
62DNA replication initiation (GO:0006270)2.75607257
63regulation of hippo signaling (GO:0035330)2.73064947
64regulation of keratinocyte proliferation (GO:0010837)2.72330772
65peptidyl-cysteine modification (GO:0018198)2.71840172
66DNA demethylation (GO:0080111)2.71557994
67telomere maintenance via recombination (GO:0000722)2.70957152
68deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.68880744
69histone mRNA catabolic process (GO:0071044)2.67468323
70morphogenesis of an epithelial sheet (GO:0002011)2.67432945
71spliceosomal tri-snRNP complex assembly (GO:0000244)2.65924668
72regulation of sarcomere organization (GO:0060297)2.65815137
73DNA replication-independent nucleosome organization (GO:0034724)2.65607476
74DNA replication-independent nucleosome assembly (GO:0006336)2.65607476
75protein-DNA complex disassembly (GO:0032986)2.65167877
76nucleosome disassembly (GO:0006337)2.65167877
77termination of RNA polymerase II transcription (GO:0006369)2.64389187
78negative regulation of mRNA processing (GO:0050686)2.64333524
79kinetochore organization (GO:0051383)2.63486625
80ribosome assembly (GO:0042255)2.63049215
81substrate-dependent cell migration (GO:0006929)2.61975228
82kinetochore assembly (GO:0051382)2.60611676
83regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.59683993
84negative regulation of systemic arterial blood pressure (GO:0003085)2.58446671
85G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.58093983
86postreplication repair (GO:0006301)2.57912276
87clathrin coat assembly (GO:0048268)2.57473647
88double-strand break repair via nonhomologous end joining (GO:0006303)2.55829511
89non-recombinational repair (GO:0000726)2.55829511
90chromatin remodeling at centromere (GO:0031055)2.55792358
91spermatid nucleus differentiation (GO:0007289)2.55549151
92mitotic recombination (GO:0006312)2.54949141
93regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54634129
94positive regulation of mitotic sister chromatid separation (GO:1901970)2.54620486
95positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54620486
96positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54620486
97peroxisome fission (GO:0016559)2.53754585
98linoleic acid metabolic process (GO:0043651)2.52152896
99stress granule assembly (GO:0034063)2.50723333
100poly(A)+ mRNA export from nucleus (GO:0016973)2.50510356
101exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49893828
102negative regulation of keratinocyte proliferation (GO:0010839)2.49885586
103cerebral cortex cell migration (GO:0021795)2.48682670
104positive regulation by symbiont of host defense response (GO:0052509)2.47231211
105modulation by symbiont of host defense response (GO:0052031)2.47231211
106modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47231211
107modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47231211
108positive regulation by organism of defense response of other organism involved in symbiotic interact2.47231211
109modulation by symbiont of host immune response (GO:0052553)2.47231211
110protein localization to microtubule cytoskeleton (GO:0072698)2.47230005
111RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.46360744
112mRNA splicing, via spliceosome (GO:0000398)2.46360744
113histone H4-K16 acetylation (GO:0043984)2.46312077
114N-terminal protein amino acid modification (GO:0031365)2.46236667
115RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.45772545
116RNA export from nucleus (GO:0006405)2.45641387
117branch elongation of an epithelium (GO:0060602)2.45420591
118DNA deamination (GO:0045006)2.45106641
119negative regulation of axon guidance (GO:1902668)2.45074116
120DNA double-strand break processing (GO:0000729)2.44964427
121regulation of chemokine-mediated signaling pathway (GO:0070099)2.44703876
122RNA splicing, via transesterification reactions (GO:0000375)2.44658245
123cell migration involved in sprouting angiogenesis (GO:0002042)2.43336925
124nucleotide-excision repair, DNA gap filling (GO:0006297)2.43083746
125substrate adhesion-dependent cell spreading (GO:0034446)2.42956881
126polyketide metabolic process (GO:0030638)2.42511219
127doxorubicin metabolic process (GO:0044598)2.42511219
128daunorubicin metabolic process (GO:0044597)2.42511219
129presynaptic membrane assembly (GO:0097105)2.42356548
130mRNA export from nucleus (GO:0006406)2.41857235
131maturation of 5.8S rRNA (GO:0000460)2.41556673
132maturation of SSU-rRNA (GO:0030490)2.41548440
133positive regulation of muscle hypertrophy (GO:0014742)2.41414044
134positive regulation of cardiac muscle hypertrophy (GO:0010613)2.41414044
135DNA replication checkpoint (GO:0000076)2.40107003
136telomere maintenance via telomere lengthening (GO:0010833)2.38756039
137spliceosomal complex assembly (GO:0000245)2.38746727
138mitotic sister chromatid cohesion (GO:0007064)2.37989850
139ether lipid metabolic process (GO:0046485)2.36882128
140artery development (GO:0060840)2.36682348
141vascular endothelial growth factor signaling pathway (GO:0038084)2.36287469
142nuclear pore organization (GO:0006999)2.34275907
143positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.32737588
144axis elongation (GO:0003401)2.32232923
145negative regulation of axon extension involved in axon guidance (GO:0048843)2.31763796
146ATP-dependent chromatin remodeling (GO:0043044)2.31676001
147megakaryocyte development (GO:0035855)2.31136849
148neuron recognition (GO:0008038)2.31046325
149negative regulation of phagocytosis (GO:0050765)2.30644144
150neural tube formation (GO:0001841)2.30622242
151histamine secretion (GO:0001821)2.30457305
152hemidesmosome assembly (GO:0031581)2.29629779
153histone H4 acetylation (GO:0043967)2.29626374
154cellular response to arsenic-containing substance (GO:0071243)2.29445949
155mRNA modification (GO:0016556)2.29177489
156asymmetric protein localization (GO:0008105)2.28887441
157Arp2/3 complex-mediated actin nucleation (GO:0034314)2.28871817
158positive regulation of male gonad development (GO:2000020)2.28829574
159regulation of establishment of cell polarity (GO:2000114)2.27951633
160sphingoid metabolic process (GO:0046519)2.27763786
161positive regulation of interleukin-1 beta secretion (GO:0050718)2.27658185
162negative regulation of protein localization to cell surface (GO:2000009)2.27545971
163DNA dealkylation (GO:0035510)2.26242730
164actin cytoskeleton reorganization (GO:0031532)2.25844331
165ectoderm development (GO:0007398)2.25362889
166nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.24742686
167regulation of mitotic metaphase/anaphase transition (GO:0030071)2.24534692
168positive regulation of histone H3-K4 methylation (GO:0051571)2.24510006
169mitotic nuclear envelope disassembly (GO:0007077)2.24501380
170regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.24407612
171negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.24305211
172negative regulation of sister chromatid segregation (GO:0033046)2.24305211
173negative regulation of mitotic sister chromatid separation (GO:2000816)2.24305211
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.24305211
175negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.24147504
176tRNA methylation (GO:0030488)2.23818937
177mitotic spindle assembly checkpoint (GO:0007094)2.23789655
178retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22736381
179embryonic hemopoiesis (GO:0035162)2.22597316
180positive regulation of DNA-dependent DNA replication (GO:2000105)2.22519501
181regulation of nuclear cell cycle DNA replication (GO:0033262)2.22402384
182mitotic cytokinesis (GO:0000281)2.21792312
183response to interferon-beta (GO:0035456)2.21433755
184spindle assembly checkpoint (GO:0071173)2.21226283
185germ cell migration (GO:0008354)2.20326610
186regulation of interferon-beta biosynthetic process (GO:0045357)2.20211193
187regulation of sulfur metabolic process (GO:0042762)2.19937371
188urogenital system development (GO:0001655)2.19853961
189blood vessel maturation (GO:0001955)2.19665391
190DNA-templated transcription, termination (GO:0006353)2.19238647
191protein localization to chromosome (GO:0034502)2.19159012
192negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.17538550
193cranial nerve morphogenesis (GO:0021602)2.17099750
194paraxial mesoderm development (GO:0048339)2.15404105
195viral mRNA export from host cell nucleus (GO:0046784)2.15287452
196negative regulation of chromosome segregation (GO:0051985)2.14167213
197DNA duplex unwinding (GO:0032508)2.13253379

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.74564795
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.92977537
3SMAD_19615063_ChIP-ChIP_OVARY_Human3.47036442
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.23379278
5RBPJ_22232070_ChIP-Seq_NCS_Mouse3.20262993
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.14113608
7CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.05227104
8TP63_19390658_ChIP-ChIP_HaCaT_Human2.76231693
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.71537023
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.69432845
11FUS_26573619_Chip-Seq_HEK293_Human2.66756450
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.66404127
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.62151114
14SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.47979815
15ELF1_17652178_ChIP-ChIP_JURKAT_Human2.47430831
16WT1_19549856_ChIP-ChIP_CCG9911_Human2.44452422
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.41065693
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.39593191
19CIITA_25753668_ChIP-Seq_RAJI_Human2.33289666
20ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.28391559
21* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.27944038
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.25275360
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.23119079
24* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.21563320
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.21091261
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.21090257
27TAF15_26573619_Chip-Seq_HEK293_Human2.20011122
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19057811
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.16016766
30NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15898311
31SCL_19346495_ChIP-Seq_HPC-7_Human2.13234149
32TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.12974928
33GBX2_23144817_ChIP-Seq_PC3_Human2.12872742
34ELK1_19687146_ChIP-ChIP_HELA_Human2.11900020
35EWS_26573619_Chip-Seq_HEK293_Human2.10992895
36HOXB4_20404135_ChIP-ChIP_EML_Mouse2.10675638
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08863797
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.08415119
39KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.06619650
40VDR_23849224_ChIP-Seq_CD4+_Human2.05763747
41MYC_19079543_ChIP-ChIP_MESCs_Mouse2.05563338
42FOXM1_23109430_ChIP-Seq_U2OS_Human2.05397165
43CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05238230
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04971067
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.04461639
46* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.02097206
47AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.01449013
48ZNF274_21170338_ChIP-Seq_K562_Hela2.01238879
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.00910557
50MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.00647352
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.99951483
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.98591474
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.96422516
54FOXP3_21729870_ChIP-Seq_TREG_Human1.95768951
55* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.94210388
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.92813932
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.92779993
58* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.90144798
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.89703845
60ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88983294
61MYC_22102868_ChIP-Seq_BL_Human1.88859360
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87351944
63* XRN2_22483619_ChIP-Seq_HELA_Human1.85226702
64MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82896457
65* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.78604496
66ER_23166858_ChIP-Seq_MCF-7_Human1.76362667
67NOTCH1_21737748_ChIP-Seq_TLL_Human1.76248775
68* ETS1_20019798_ChIP-Seq_JURKAT_Human1.74792228
69HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.73277190
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72670683
71SPI1_23547873_ChIP-Seq_NB4_Human1.70871551
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.70432626
73GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.70139123
74SMAD4_21799915_ChIP-Seq_A2780_Human1.68832506
75MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66441918
76EP300_21415370_ChIP-Seq_HL-1_Mouse1.66048642
77P300_19829295_ChIP-Seq_ESCs_Human1.65099572
78CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62180750
79SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.61755672
80IRF8_22096565_ChIP-ChIP_GC-B_Human1.61296068
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.61086218
82TP53_18474530_ChIP-ChIP_U2OS_Human1.60942716
83CREB1_15753290_ChIP-ChIP_HEK293T_Human1.59464614
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59027356
85* DCP1A_22483619_ChIP-Seq_HELA_Human1.56933929
86BRD4_25478319_ChIP-Seq_HGPS_Human1.56210429
87E2F1_18555785_ChIP-Seq_MESCs_Mouse1.55930662
88GABP_19822575_ChIP-Seq_HepG2_Human1.52910905
89* TTF2_22483619_ChIP-Seq_HELA_Human1.52757474
90TCF4_18268006_ChIP-ChIP_LS174T_Human1.52604569
91* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.51823851
92CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.51042501
93SALL1_21062744_ChIP-ChIP_HESCs_Human1.50549607
94CJUN_26792858_Chip-Seq_BT549_Human1.48895061
95PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.47548726
96MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.46799812
97AR_21909140_ChIP-Seq_LNCAP_Human1.45644160
98SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45395873
99THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45220437
100TP63_17297297_ChIP-ChIP_HaCaT_Human1.44494213
101CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.41870780
102CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.39960241
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.39112016
104AR_21572438_ChIP-Seq_LNCaP_Human1.39035977
105FLI1_27457419_Chip-Seq_LIVER_Mouse1.38878366
106TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38548033
107FOXM1_26456572_ChIP-Seq_MCF-7_Human1.37941334
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37087558
109NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36559750
110TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.33750539
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.33187717
112TP53_16413492_ChIP-PET_HCT116_Human1.32516595
113SOX9_26525672_Chip-Seq_HEART_Mouse1.31790353
114STAT3_23295773_ChIP-Seq_U87_Human1.31516672
115NANOG_18555785_Chip-Seq_ESCs_Mouse1.30277254
116CBP_20019798_ChIP-Seq_JUKART_Human1.29381502
117IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.29381502
118PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28838647
119PADI4_21655091_ChIP-ChIP_MCF-7_Human1.27796013
120* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.26734857
121POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.26553698
122TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26553698
123* SMAD3_21741376_ChIP-Seq_EPCs_Human1.25942236
124EZH2_27294783_Chip-Seq_NPCs_Mouse1.25184037
125AHR_22903824_ChIP-Seq_MCF-7_Human1.23178984
126ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22428692
127SALL4_18804426_ChIP-ChIP_XEN_Mouse1.20225095
128PCGF2_27294783_Chip-Seq_NPCs_Mouse1.20190436
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19914134
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.17945454
131CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17452758
132TOP2B_26459242_ChIP-Seq_MCF-7_Human1.17335908
133SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16735660
134SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16735660
135STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.15472244
136TP63_23658742_ChIP-Seq_EP156T_Human1.15439181
137NR3C1_21868756_ChIP-Seq_MCF10A_Human1.15432785
138SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14731701
139NFE2_27457419_Chip-Seq_LIVER_Mouse1.14513316
140FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.14448279
141CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12115990
142NRF2_20460467_ChIP-Seq_MEFs_Mouse1.12106829
143NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.12106829
144* CDX2_22108803_ChIP-Seq_LS180_Human1.12004126
145IGF1R_20145208_ChIP-Seq_DFB_Human1.11970838
146EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.11826287
147HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11492935
148TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11098837
149PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10960827
150TCF4_23295773_ChIP-Seq_U87_Human1.10383947
151GATA1_22025678_ChIP-Seq_K562_Human1.10355910
152TBX3_20139965_ChIP-Seq_MESCs_Mouse1.10055800
153* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09733443
154TRIM28_21343339_ChIP-Seq_HEK293_Human1.08051318
155* FLI1_21867929_ChIP-Seq_TH2_Mouse1.07355951
156SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.07307327
157UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.06867902
158RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.06335661
159DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06185503
160VDR_21846776_ChIP-Seq_THP-1_Human1.05550185
161MYB_26560356_Chip-Seq_TH2_Human1.04142283
162MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03962240
163STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.03831963
164P300_18555785_Chip-Seq_ESCs_Mouse1.03162869
165VDR_22108803_ChIP-Seq_LS180_Human1.01848003
166MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.01603757
167E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01110464
168CRX_20693478_ChIP-Seq_RETINA_Mouse0.99786707
169CMYC_18555785_Chip-Seq_ESCs_Mouse0.99752716
170KDM5A_27292631_Chip-Seq_BREAST_Human0.98864117
171* RUNX2_22187159_ChIP-Seq_PCA_Human0.98798536
172ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97924212
173NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.97291562
174KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97243014
175IRF8_27001747_Chip-Seq_BMDM_Mouse0.95559113
176SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95483060
177STAT4_19710469_ChIP-ChIP_TH1__Mouse0.93916493
178STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92601190
179NANOG_18555785_ChIP-Seq_MESCs_Mouse0.91397617
180TFEB_21752829_ChIP-Seq_HELA_Human0.90149567
181MYC_18940864_ChIP-ChIP_HL60_Human0.89882365
182RUNX1_22412390_ChIP-Seq_EML_Mouse0.87983010
183POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87302803
184CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.85846881
185SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85612890

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system2.65924352
2MP0008007_abnormal_cellular_replicative2.61245454
3MP0010030_abnormal_orbit_morphology2.56553181
4MP0010094_abnormal_chromosome_stability2.50628723
5MP0004233_abnormal_muscle_weight2.28419888
6MP0005248_abnormal_Harderian_gland2.17721466
7MP0003221_abnormal_cardiomyocyte_apopto2.07464360
8MP0003121_genomic_imprinting2.05676171
9MP0000015_abnormal_ear_pigmentation2.02028618
10MP0008058_abnormal_DNA_repair2.01943582
11MP0002095_abnormal_skin_pigmentation1.98539881
12MP0002938_white_spotting1.93341448
13MP0003077_abnormal_cell_cycle1.91279008
14MP0004808_abnormal_hematopoietic_stem1.87858379
15MP0005623_abnormal_meninges_morphology1.86895824
16MP0001835_abnormal_antigen_presentation1.85953483
17MP0003693_abnormal_embryo_hatching1.85244441
18MP0003941_abnormal_skin_development1.81205723
19MP0005174_abnormal_tail_pigmentation1.80734424
20MP0008057_abnormal_DNA_replication1.75041580
21MP0004133_heterotaxia1.73565701
22MP0003385_abnormal_body_wall1.71825735
23MP0003950_abnormal_plasma_membrane1.70459441
24MP0000566_synostosis1.69870955
25MP0000490_abnormal_crypts_of1.69698815
26MP0003111_abnormal_nucleus_morphology1.64268413
27MP0006054_spinal_hemorrhage1.62613890
28MP0003315_abnormal_perineum_morphology1.59273172
29MP0008438_abnormal_cutaneous_collagen1.57069366
30MP0004084_abnormal_cardiac_muscle1.56802171
31MP0004957_abnormal_blastocyst_morpholog1.54855390
32MP0002127_abnormal_cardiovascular_syste1.47139395
33MP0001293_anophthalmia1.46926403
34MP0003566_abnormal_cell_adhesion1.46167264
35MP0010678_abnormal_skin_adnexa1.43782598
36MP0005275_abnormal_skin_tensile1.42244864
37MP0000383_abnormal_hair_follicle1.41870295
38MP0001879_abnormal_lymphatic_vessel1.40951079
39MP0003786_premature_aging1.40389294
40MP0003943_abnormal_hepatobiliary_system1.40076146
41MP0000569_abnormal_digit_pigmentation1.37699621
42MP0001915_intracranial_hemorrhage1.37657397
43MP0002009_preneoplasia1.37159751
44MP0004134_abnormal_chest_morphology1.35292958
45MP0006292_abnormal_olfactory_placode1.34827767
46MP0002638_abnormal_pupillary_reflex1.33624248
47MP0000427_abnormal_hair_cycle1.33190475
48MP0000681_abnormal_thyroid_gland1.32708442
49MP0003763_abnormal_thymus_physiology1.32047238
50MP0008932_abnormal_embryonic_tissue1.31909151
51MP0000465_gastrointestinal_hemorrhage1.31309717
52MP0002282_abnormal_trachea_morphology1.30290510
53MP0001661_extended_life_span1.30010091
54MP0001299_abnormal_eye_distance/1.28395943
55MP0002168_other_aberrant_phenotype1.28376574
56MP0000537_abnormal_urethra_morphology1.27837253
57MP0002088_abnormal_embryonic_growth/wei1.26971201
58MP0002090_abnormal_vision1.26758279
59MP0003122_maternal_imprinting1.26523326
60MP0005671_abnormal_response_to1.25423778
61MP0010368_abnormal_lymphatic_system1.25416037
62MP0005075_abnormal_melanosome_morpholog1.24937588
63MP0004883_abnormal_blood_vessel1.24614035
64MP0003123_paternal_imprinting1.24151897
65MP0002452_abnormal_antigen_presenting1.23841347
66MP0005409_darkened_coat_color1.23670072
67MP0003942_abnormal_urinary_system1.23661560
68MP0000049_abnormal_middle_ear1.23281508
69MP0000350_abnormal_cell_proliferation1.22766489
70MP0002398_abnormal_bone_marrow1.22130948
71MP0002102_abnormal_ear_morphology1.21913683
72MP0002697_abnormal_eye_size1.21072043
73MP0001177_atelectasis1.19378191
74MP0001188_hyperpigmentation1.18816950
75MP0000751_myopathy1.18346176
76MP0008877_abnormal_DNA_methylation1.18085621
77MP0003011_delayed_dark_adaptation1.16661419
78MP0002166_altered_tumor_susceptibility1.15946762
79MP0002249_abnormal_larynx_morphology1.15932209
80MP0000647_abnormal_sebaceous_gland1.15652305
81MP0002972_abnormal_cardiac_muscle1.15649295
82MP0010234_abnormal_vibrissa_follicle1.12380205
83MP0005187_abnormal_penis_morphology1.11316664
84MP0002877_abnormal_melanocyte_morpholog1.10328724
85MP0005171_absent_coat_pigmentation1.09632830
86MP0003868_abnormal_feces_composition1.09546264
87MP0002420_abnormal_adaptive_immunity1.08241262
88MP0001819_abnormal_immune_cell1.07584783
89MP0000358_abnormal_cell_content/1.06870797
90MP0002006_tumorigenesis1.06627631
91MP0002233_abnormal_nose_morphology1.06252386
92MP0002177_abnormal_outer_ear1.06057906
93MP0000534_abnormal_ureter_morphology1.05957033
94MP0000778_abnormal_nervous_system1.05816967
95MP0003755_abnormal_palate_morphology1.05573963
96MP0009053_abnormal_anal_canal1.05136111
97MP0003787_abnormal_imprinting1.04419374
98MP0002332_abnormal_exercise_endurance1.03497727
99MP0000013_abnormal_adipose_tissue1.03492725
100MP0005503_abnormal_tendon_morphology1.03362728
101MP0003937_abnormal_limbs/digits/tail_de1.01651172
102MP0000428_abnormal_craniofacial_morphol1.01637189
103MP0002419_abnormal_innate_immunity1.01544824
104MP0001800_abnormal_humoral_immune1.00742890
105MP0009697_abnormal_copulation1.00209320
106MP0000685_abnormal_immune_system1.00183488
107MP0009333_abnormal_splenocyte_physiolog0.99724556
108MP0002234_abnormal_pharynx_morphology0.99207333
109MP0000689_abnormal_spleen_morphology0.98643959
110MP0001958_emphysema0.98431189
111MP0000703_abnormal_thymus_morphology0.97839403
112MP0010352_gastrointestinal_tract_polyps0.97443176
113MP0003183_abnormal_peptide_metabolism0.96966550
114MP0000678_abnormal_parathyroid_gland0.96930727
115MP0002269_muscular_atrophy0.96558369
116MP0000313_abnormal_cell_death0.96166374
117MP0000716_abnormal_immune_system0.95416191
118MP0001697_abnormal_embryo_size0.95375837
119MP0003567_abnormal_fetal_cardiomyocyte0.95332567
120MP0009785_altered_susceptibility_to0.95049136
121MP0002925_abnormal_cardiovascular_devel0.94226404
122MP0003935_abnormal_craniofacial_develop0.94121589
123MP0002085_abnormal_embryonic_tissue0.94111757
124MP0000749_muscle_degeneration0.94101075
125MP0005620_abnormal_muscle_contractility0.93643264
126MP0000767_abnormal_smooth_muscle0.92557226
127MP0002429_abnormal_blood_cell0.92458072
128MP0003724_increased_susceptibility_to0.92122175
129MP0003890_abnormal_embryonic-extraembry0.92001726
130MP0003705_abnormal_hypodermis_morpholog0.91812967
131MP0002092_abnormal_eye_morphology0.91611834
132MP0005395_other_phenotype0.91370816
133MP0005076_abnormal_cell_differentiation0.90451094
134MP0003436_decreased_susceptibility_to0.90177532
135MP0004272_abnormal_basement_membrane0.90111076
136MP0001545_abnormal_hematopoietic_system0.89788138
137MP0005397_hematopoietic_system_phenotyp0.89788138
138MP0004197_abnormal_fetal_growth/weight/0.89680514
139MP0004782_abnormal_surfactant_physiolog0.89302584
140MP0002084_abnormal_developmental_patter0.89216497
141MP0002722_abnormal_immune_system0.87728158
142MP0005647_abnormal_sex_gland0.86866888
143MP0002723_abnormal_immune_serum0.86314864
144MP0000266_abnormal_heart_morphology0.85690939
145MP0003115_abnormal_respiratory_system0.85389814
146MP0004484_altered_response_of0.84654865
147MP0001119_abnormal_female_reproductive0.84534015
148MP0002896_abnormal_bone_mineralization0.84017398
149MP0002086_abnormal_extraembryonic_tissu0.83942525
150MP0002837_dystrophic_cardiac_calcinosis0.83748852
151MP0006035_abnormal_mitochondrial_morpho0.83670055
152MP0005000_abnormal_immune_tolerance0.83420406
153MP0003045_fibrosis0.83397993
154MP0000733_abnormal_muscle_development0.82830208
155MP0003984_embryonic_growth_retardation0.82670666
156MP0001730_embryonic_growth_arrest0.82434253
157MP0005645_abnormal_hypothalamus_physiol0.82339309
158MP0010307_abnormal_tumor_latency0.82269843
159MP0002751_abnormal_autonomic_nervous0.82085708
160MP0005380_embryogenesis_phenotype0.82031214
161MP0001672_abnormal_embryogenesis/_devel0.82031214
162MP0002113_abnormal_skeleton_development0.81715184
163MP0003646_muscle_fatigue0.78759670
164MP0002080_prenatal_lethality0.78473645
165MP0000377_abnormal_hair_follicle0.77813938
166MP0005621_abnormal_cell_physiology0.77707001
167MP0005384_cellular_phenotype0.77402886
168MP0005391_vision/eye_phenotype0.76454232
169MP0001175_abnormal_lung_morphology0.76135253
170MP0003091_abnormal_cell_migration0.76064988
171MP0005197_abnormal_uvea_morphology0.75570256
172MP0000516_abnormal_urinary_system0.74928099

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)6.00931819
2Back pain (HP:0003418)5.18719684
3Abnormal umbilical cord blood vessels (HP:0011403)4.33038741
4Single umbilical artery (HP:0001195)4.33038741
5Abnormality of the fetal cardiovascular system (HP:0010948)4.33038741
6Thyroid carcinoma (HP:0002890)4.05153449
7Diastasis recti (HP:0001540)3.89772361
8B lymphocytopenia (HP:0010976)3.87732145
9Myelomeningocele (HP:0002475)3.50291905
10Thyroiditis (HP:0100646)3.46015848
1111 pairs of ribs (HP:0000878)3.32422411
12Overlapping toe (HP:0001845)3.29866021
13Curly hair (HP:0002212)3.19742501
14Insidious onset (HP:0003587)3.19634076
15Termporal pattern (HP:0011008)3.19634076
16Vertebral arch anomaly (HP:0008438)3.07674496
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.05457716
18Short 4th metacarpal (HP:0010044)3.05457716
19Abnormality of B cell number (HP:0010975)3.04047535
20Aplastic anemia (HP:0001915)2.91732887
21Cortical dysplasia (HP:0002539)2.88501603
22Abnormality of the lower motor neuron (HP:0002366)2.82520236
23Abnormality of the umbilical cord (HP:0010881)2.79425218
24Stenosis of the external auditory canal (HP:0000402)2.75876654
25Bifid tongue (HP:0010297)2.71708238
26Spinal cord lesions (HP:0100561)2.70801329
27Syringomyelia (HP:0003396)2.70801329
28Cutaneous melanoma (HP:0012056)2.70753613
29Reticulocytopenia (HP:0001896)2.60449306
30Chromsome breakage (HP:0040012)2.59989076
31Hypoplasia of the thymus (HP:0000778)2.57822207
32Birth length less than 3rd percentile (HP:0003561)2.52821325
33Severe combined immunodeficiency (HP:0004430)2.50847221
34Large earlobe (HP:0009748)2.46075146
35Absent speech (HP:0001344)2.44665980
36Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.41721954
37Subacute progressive viral hepatitis (HP:0006572)2.39948039
38Poikiloderma (HP:0001029)2.36589631
39Transitional cell carcinoma of the bladder (HP:0006740)2.33545239
40Calcaneovalgus deformity (HP:0001848)2.32447164
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.31795757
42Abnormality of the nasal septum (HP:0000419)2.31680637
43Bladder neoplasm (HP:0009725)2.31546149
44Bladder carcinoma (HP:0002862)2.31546149
45Abnormal ventriculo-arterial connection (HP:0011563)2.29187871
46Transposition of the great arteries (HP:0001669)2.29187871
47Abnormal connection of the cardiac segments (HP:0011545)2.29187871
48Abnormality of the columella (HP:0009929)2.25975858
49High anterior hairline (HP:0009890)2.25085877
50True hermaphroditism (HP:0010459)2.25046394
51Ectopic kidney (HP:0000086)2.24347157
52Selective tooth agenesis (HP:0001592)2.24168083
53Asymmetry of the thorax (HP:0001555)2.23362538
54Abnormal lung lobation (HP:0002101)2.15310794
55Abnormal number of erythroid precursors (HP:0012131)2.14687632
56Colon cancer (HP:0003003)2.14669498
57Patellar aplasia (HP:0006443)2.14587197
58Entropion (HP:0000621)2.12957012
59Combined immunodeficiency (HP:0005387)2.12442822
60Ectopic anus (HP:0004397)2.11811525
61Hypoproteinemia (HP:0003075)2.11697519
62Chin dimple (HP:0010751)2.11057806
63Abnormality of the musculature of the pelvis (HP:0001469)2.09880187
64Abnormality of the hip-girdle musculature (HP:0001445)2.09880187
65Delayed gross motor development (HP:0002194)2.08665750
66Uterine leiomyosarcoma (HP:0002891)2.08607277
67Leiomyosarcoma (HP:0100243)2.08607277
68Short middle phalanx of the 5th finger (HP:0004220)2.07854356
69Aplasia/Hypoplasia of the sternum (HP:0006714)2.05464996
70Arnold-Chiari malformation (HP:0002308)2.04811374
71Long eyelashes (HP:0000527)2.04279368
72Arterial tortuosity (HP:0005116)2.03991480
73Abnormalities of placenta or umbilical cord (HP:0001194)2.03166573
74Vitreoretinal degeneration (HP:0000655)2.01378254
75Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.01225490
76Maternal diabetes (HP:0009800)2.01115117
77Abnormality of the anterior horn cell (HP:0006802)1.98436752
78Degeneration of anterior horn cells (HP:0002398)1.98436752
79Mitral stenosis (HP:0001718)1.98295142
80Lower limb hyperreflexia (HP:0002395)1.98112504
81Aplasia/Hypoplasia of the patella (HP:0006498)1.97063011
82Deformed tarsal bones (HP:0008119)1.97021254
83Pulmonic stenosis (HP:0001642)1.96023028
84Abnormality of the fingertips (HP:0001211)1.95924137
85Hepatoblastoma (HP:0002884)1.95303671
86Disinhibition (HP:0000734)1.95136219
87Limited elbow extension (HP:0001377)1.93911360
88Capillary hemangiomas (HP:0005306)1.93798477
89Abnormality of cells of the erythroid lineage (HP:0012130)1.93038045
90Absent frontal sinuses (HP:0002688)1.92803149
91Fibular hypoplasia (HP:0003038)1.92460787
92Abnormality of the intervertebral disk (HP:0005108)1.92122702
93Volvulus (HP:0002580)1.90932179
94Cystic hygroma (HP:0000476)1.90711115
95Abnormal auditory evoked potentials (HP:0006958)1.89360605
96Medulloblastoma (HP:0002885)1.88643464
97Microglossia (HP:0000171)1.88248524
98Myelodysplasia (HP:0002863)1.87778463
99Malignant gastrointestinal tract tumors (HP:0006749)1.86863177
100Gastrointestinal carcinoma (HP:0002672)1.86863177
101Optic nerve coloboma (HP:0000588)1.86167372
102Cubitus valgus (HP:0002967)1.83323011
103Abnormality of the calcaneus (HP:0008364)1.81410392
104Abnormality of the 4th metacarpal (HP:0010012)1.81342820
105Recurrent abscess formation (HP:0002722)1.80272833
106Abnormality of the left ventricular outflow tract (HP:0011103)1.78700254
107Subaortic stenosis (HP:0001682)1.78700254
108Eosinophilia (HP:0001880)1.77908625
109IgM deficiency (HP:0002850)1.76914307
110Missing ribs (HP:0000921)1.75453042
111Vascular tortuosity (HP:0004948)1.74586375
112Thrombocytosis (HP:0001894)1.74323091
113Neoplasm of the thyroid gland (HP:0100031)1.74146549
114Hypoplasia of the iris (HP:0007676)1.73601974
115Drooling (HP:0002307)1.72755376
116Urethral obstruction (HP:0000796)1.72343053
117Aplasia/Hypoplasia of the sacrum (HP:0008517)1.70395488
118Myositis (HP:0100614)1.69986888
119Bilateral sensorineural hearing impairment (HP:0008619)1.69927168
120Meningocele (HP:0002435)1.68949981
121Renal duplication (HP:0000075)1.66285953
122Abnormality of chromosome stability (HP:0003220)1.66061810
123Long clavicles (HP:0000890)1.65991663
124Hammertoe (HP:0001765)1.65527000
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.65336565
126Neoplasm of the adrenal cortex (HP:0100641)1.65199092
127Aplasia/Hypoplasia of the fibula (HP:0006492)1.65114080
128Ulnar bowing (HP:0003031)1.65011842
129Ankle contracture (HP:0006466)1.64981451
130Abnormality of the astrocytes (HP:0100707)1.64817168
131Astrocytoma (HP:0009592)1.64817168
132Deviation of the thumb (HP:0009603)1.64148325
133Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.63790224
134Nephroblastoma (Wilms tumor) (HP:0002667)1.63638574
135Acute myeloid leukemia (HP:0004808)1.63613633
136Thick nail (HP:0001805)1.62067136
137Deep philtrum (HP:0002002)1.61182508
138Mediastinal lymphadenopathy (HP:0100721)1.60551044
139Enlarged kidneys (HP:0000105)1.60336333
140Abnormality of DNA repair (HP:0003254)1.58706743
141Spondylolisthesis (HP:0003302)1.58373365
142Elevated erythrocyte sedimentation rate (HP:0003565)1.58150515
143Breast hypoplasia (HP:0003187)1.58141835
144Pelvic girdle muscle weakness (HP:0003749)1.57791160
145Facial diplegia (HP:0001349)1.57770515
146Arthropathy (HP:0003040)1.56987354
147Broad thumb (HP:0011304)1.56757307
148Amyotrophic lateral sclerosis (HP:0007354)1.56699773
149Exercise-induced myalgia (HP:0003738)1.56436912
150Proximal placement of thumb (HP:0009623)1.55970201
151Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.55186682
152Pancreatic fibrosis (HP:0100732)1.55135728
153Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.54959929
154Heterochromia iridis (HP:0001100)1.54907179
155Duodenal stenosis (HP:0100867)1.54050092
156Small intestinal stenosis (HP:0012848)1.54050092
157Abnormality of the phalanges of the 5th finger (HP:0004213)1.53278483
158Meckel diverticulum (HP:0002245)1.53018986
159Inappropriate behavior (HP:0000719)1.52691582
160Embryonal renal neoplasm (HP:0011794)1.52375854
161Pendular nystagmus (HP:0012043)1.51594607
162Agnosia (HP:0010524)1.50756708
163Excessive salivation (HP:0003781)1.50497852
164Progressive inability to walk (HP:0002505)1.50358325
165Glossoptosis (HP:0000162)1.50104243
166Pulmonary fibrosis (HP:0002206)1.49800716
167Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.49677080
168Lymphoma (HP:0002665)1.49523596
169Hypoplastic iliac wings (HP:0002866)1.49324666
170Bone marrow hypocellularity (HP:0005528)1.49116713
171Prominent nose (HP:0000448)1.48826057
172Abnormality of the phalanges of the hallux (HP:0010057)1.48677762
173Short palpebral fissure (HP:0012745)1.48616535
174Clubbing of toes (HP:0100760)1.48543763
175Pallor (HP:0000980)1.48529048
176Abnormality of the carotid arteries (HP:0005344)1.48346643
177Short 5th finger (HP:0009237)1.47597541
178Increased nuchal translucency (HP:0010880)1.46318002
179Spontaneous hematomas (HP:0007420)1.45097709
180Vertebral hypoplasia (HP:0008417)1.43915011
181Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.43915011
182Abnormal number of incisors (HP:0011064)1.42935180
183Broad phalanges of the hand (HP:0009768)1.42710920
184Abnormal hair whorl (HP:0010721)1.42523595
185Aseptic necrosis (HP:0010885)1.42299448
186Lymphopenia (HP:0001888)1.42165748
187Atresia of the external auditory canal (HP:0000413)1.42093910
188Abnormality of cells of the lymphoid lineage (HP:0012140)1.41298618
189Abnormality of the parietal bone (HP:0002696)1.41115429
190Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.40527997
191Abnormality of the prostate (HP:0008775)1.40162990

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMK1G4.18596705
2MKNK14.12209969
3CAMK1D4.09213631
4PNCK3.91996017
5SRPK13.45070761
6TGFBR13.28595928
7PRKD32.98423935
8ACVR1B2.88659407
9MAP4K22.73803251
10LATS12.71729675
11CDC72.57456873
12KIT2.50093216
13EIF2AK12.31135456
14ERBB32.30355732
15MKNK22.28382047
16CDK122.16604799
17TGFBR22.10576674
18VRK12.08580329
19SIK32.08066794
20PASK2.06836734
21TRIM281.99705428
22BMPR1B1.98533080
23STK38L1.88290954
24FRK1.87110226
25ATR1.84594388
26BTK1.71417871
27ERBB41.70883082
28WEE11.66569495
29EPHB21.55856583
30PDGFRA1.55441875
31CAMKK21.52667441
32CSF1R1.50984424
33DYRK31.45702099
34TLK11.40438567
35IRAK41.39978467
36MST41.37822326
37CDK81.37628572
38CDK71.36524979
39BRSK21.34564859
40FLT31.30853980
41RPS6KA41.29989580
42CLK11.28769116
43FER1.28206026
44MATK1.26494623
45TEC1.23952890
46SCYL21.21881903
47CASK1.20512808
48YES11.19238444
49BCR1.18062552
50BRD41.17890891
51NUAK11.17848323
52CCNB11.17574601
53DYRK21.17546071
54MET1.14986976
55PAK41.12581512
56CSNK1A1L1.10935963
57MELK1.10601598
58PLK41.10527911
59TSSK61.09919885
60CDK91.08317768
61PLK21.05875860
62INSRR1.05691894
63TYK21.04044191
64BLK0.98085060
65PAK30.96424545
66STK30.95984686
67PLK30.95802750
68PIK3CG0.94064200
69EPHA30.93897692
70MAP3K40.92207383
71PIM10.88599843
72TAF10.88293794
73CSNK1G10.87207874
74CDK40.87145034
75LATS20.85722593
76LYN0.84303164
77TNIK0.82769840
78CHUK0.82248619
79NEK10.82244646
80MAP4K10.79206663
81ZAP700.78769422
82CHEK20.77300623
83PTK60.76376870
84WNK30.76319940
85CSNK1G30.75947582
86TIE10.75776062
87STK100.74828008
88SGK20.74014649
89MYLK0.73539388
90NEK90.73016240
91MAPK130.71918491
92EIF2AK30.71721467
93CSNK1G20.70223948
94ATM0.69995045
95BUB10.68199864
96MST1R0.68061609
97EEF2K0.67821872
98NLK0.66539249
99PTK20.65840698
100OBSCN0.63702640
101JAK30.63131723
102PRKAA10.62405513
103RPS6KB10.62170582
104RPS6KB20.61672271
105CDK60.61225846
106KDR0.61197941
107PDGFRB0.61173537
108TXK0.60735689
109NEK60.60517521
110PLK10.59918773
111IKBKE0.59313640
112MARK10.58347795
113CAMK40.58225100
114MAP2K70.58197281
115AURKB0.57866636
116PRKCE0.57543604
117CHEK10.57103029
118PTK2B0.53869345
119PBK0.51787415
120AKT30.51261510
121CDK20.50178315
122LCK0.49984664
123EIF2AK20.48046202
124CDK50.47508533
125TAOK20.47203012
126SYK0.46746333
127PINK10.45175580
128IKBKB0.44569449
129NEK20.44289431
130DYRK1B0.43831685
131PDK20.43663614
132MAP3K120.40091076
133KSR10.40019210
134UHMK10.39283858
135PRKAA20.38523784
136RPS6KA50.38231812
137FGFR10.38083615
138ZAK0.37948406
139SGK30.37361451
140FGFR30.37292448
141PRKD20.36972827
142CDK10.36739095
143CAMK10.36573109
144NTRK10.36534557
145MAP3K50.36521933
146PIM20.36150647
147PRPF4B0.35790149
148CSNK2A10.35702634
149MAPK30.35027890
150CSNK2A20.34568045
151MINK10.34182032
152MAPK40.34008712
153ROCK10.33309895
154TTK0.32318378

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.32213886
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.18819142
3Spliceosome_Homo sapiens_hsa030402.68608042
4Base excision repair_Homo sapiens_hsa034102.61948900
5Mismatch repair_Homo sapiens_hsa034302.49265730
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.47461969
7Steroid biosynthesis_Homo sapiens_hsa001002.25132417
8Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.17109322
9Cell cycle_Homo sapiens_hsa041102.10741542
10Non-homologous end-joining_Homo sapiens_hsa034501.99437840
11RNA polymerase_Homo sapiens_hsa030201.98717511
12RNA transport_Homo sapiens_hsa030131.94457257
13Homologous recombination_Homo sapiens_hsa034401.87881845
14Ribosome_Homo sapiens_hsa030101.87341091
15Nucleotide excision repair_Homo sapiens_hsa034201.85699874
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.82437032
17RNA degradation_Homo sapiens_hsa030181.70945605
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69284599
19mRNA surveillance pathway_Homo sapiens_hsa030151.68582280
20Fanconi anemia pathway_Homo sapiens_hsa034601.66212976
21Herpes simplex infection_Homo sapiens_hsa051681.59757122
22Phosphatidylinositol signaling system_Homo sapiens_hsa040701.58310236
23Pyrimidine metabolism_Homo sapiens_hsa002401.57292572
24Selenocompound metabolism_Homo sapiens_hsa004501.54930544
25Basal transcription factors_Homo sapiens_hsa030221.54643758
26Axon guidance_Homo sapiens_hsa043601.53582977
27Propanoate metabolism_Homo sapiens_hsa006401.46242879
28Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42790874
29One carbon pool by folate_Homo sapiens_hsa006701.33332947
30Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.33194888
31Protein export_Homo sapiens_hsa030601.29858421
32Focal adhesion_Homo sapiens_hsa045101.28913259
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27755169
34Leishmaniasis_Homo sapiens_hsa051401.26184292
35Legionellosis_Homo sapiens_hsa051341.25746068
36ECM-receptor interaction_Homo sapiens_hsa045121.25255682
37Proteasome_Homo sapiens_hsa030501.24651746
38Antigen processing and presentation_Homo sapiens_hsa046121.24302139
39Fatty acid metabolism_Homo sapiens_hsa012121.24144649
40Measles_Homo sapiens_hsa051621.22499556
41Inositol phosphate metabolism_Homo sapiens_hsa005621.22255272
42Notch signaling pathway_Homo sapiens_hsa043301.21214018
43N-Glycan biosynthesis_Homo sapiens_hsa005101.19074718
44Other glycan degradation_Homo sapiens_hsa005111.17938655
45Transcriptional misregulation in cancer_Homo sapiens_hsa052021.17716000
46Shigellosis_Homo sapiens_hsa051311.13318040
47Sulfur metabolism_Homo sapiens_hsa009201.10528745
48Hepatitis B_Homo sapiens_hsa051611.09193218
49Epstein-Barr virus infection_Homo sapiens_hsa051691.08120337
50Influenza A_Homo sapiens_hsa051641.07467848
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06600033
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05075378
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.04727620
54Regulation of actin cytoskeleton_Homo sapiens_hsa048101.04486024
55p53 signaling pathway_Homo sapiens_hsa041151.04388888
56Small cell lung cancer_Homo sapiens_hsa052221.03917300
57Thyroid cancer_Homo sapiens_hsa052161.03865220
58HTLV-I infection_Homo sapiens_hsa051661.02975324
59Basal cell carcinoma_Homo sapiens_hsa052171.02843833
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.01638625
61Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01379193
62Central carbon metabolism in cancer_Homo sapiens_hsa052300.99351023
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.99299819
64Hematopoietic cell lineage_Homo sapiens_hsa046400.98193251
65Colorectal cancer_Homo sapiens_hsa052100.97535864
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.95839081
67TGF-beta signaling pathway_Homo sapiens_hsa043500.95652515
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95593032
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.95392193
70B cell receptor signaling pathway_Homo sapiens_hsa046620.94184258
71Wnt signaling pathway_Homo sapiens_hsa043100.92581233
72Renal cell carcinoma_Homo sapiens_hsa052110.91089144
73MicroRNAs in cancer_Homo sapiens_hsa052060.89977364
74Viral carcinogenesis_Homo sapiens_hsa052030.89175294
75Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88464447
76Jak-STAT signaling pathway_Homo sapiens_hsa046300.88055285
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.86777500
78Hedgehog signaling pathway_Homo sapiens_hsa043400.86663592
79Fatty acid elongation_Homo sapiens_hsa000620.86308255
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85616136
81Oocyte meiosis_Homo sapiens_hsa041140.85593175
82Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85461627
83Viral myocarditis_Homo sapiens_hsa054160.84766632
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84734251
85Alcoholism_Homo sapiens_hsa050340.84558135
86Chronic myeloid leukemia_Homo sapiens_hsa052200.83893518
87Choline metabolism in cancer_Homo sapiens_hsa052310.82958078
88Purine metabolism_Homo sapiens_hsa002300.79589265
89Toxoplasmosis_Homo sapiens_hsa051450.77829999
90Apoptosis_Homo sapiens_hsa042100.77568817
91Primary immunodeficiency_Homo sapiens_hsa053400.77543697
92Systemic lupus erythematosus_Homo sapiens_hsa053220.76967322
93Fatty acid biosynthesis_Homo sapiens_hsa000610.74988173
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.74982626
95Glioma_Homo sapiens_hsa052140.74446078
96Malaria_Homo sapiens_hsa051440.73859014
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73710188
98Melanoma_Homo sapiens_hsa052180.73696592
99Pancreatic cancer_Homo sapiens_hsa052120.73693321
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73232014
101Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70902456
102Sphingolipid signaling pathway_Homo sapiens_hsa040710.70884861
103Acute myeloid leukemia_Homo sapiens_hsa052210.70727621
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.70113133
105Pertussis_Homo sapiens_hsa051330.69564700
106Osteoclast differentiation_Homo sapiens_hsa043800.68954403
107Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.68808926
108NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68352426
109Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66861689
110Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.65479742
111Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.65134557
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65015144
113Pathways in cancer_Homo sapiens_hsa052000.64864243
114Amoebiasis_Homo sapiens_hsa051460.64194505
115Hippo signaling pathway_Homo sapiens_hsa043900.64108621
116Dilated cardiomyopathy_Homo sapiens_hsa054140.63787449
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62143327
118Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.61890021
119Lysine degradation_Homo sapiens_hsa003100.61482498
120Long-term depression_Homo sapiens_hsa047300.61343653
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.59968076
122FoxO signaling pathway_Homo sapiens_hsa040680.59826438
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59057229
124Dorso-ventral axis formation_Homo sapiens_hsa043200.58441073
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.57798964
126Cysteine and methionine metabolism_Homo sapiens_hsa002700.57248163
127Platelet activation_Homo sapiens_hsa046110.57158439
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56880590
129Hepatitis C_Homo sapiens_hsa051600.56533361
130Tight junction_Homo sapiens_hsa045300.56309138
131mTOR signaling pathway_Homo sapiens_hsa041500.56299130
132Renin secretion_Homo sapiens_hsa049240.56263582
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.56243056
134Rap1 signaling pathway_Homo sapiens_hsa040150.56073390
135Allograft rejection_Homo sapiens_hsa053300.55923355
136Vitamin B6 metabolism_Homo sapiens_hsa007500.55800941
137Estrogen signaling pathway_Homo sapiens_hsa049150.55784271
138Vibrio cholerae infection_Homo sapiens_hsa051100.55411623
139Endometrial cancer_Homo sapiens_hsa052130.55215022
140Glycerolipid metabolism_Homo sapiens_hsa005610.54980292
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54836644
142Non-small cell lung cancer_Homo sapiens_hsa052230.54636192
143Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53413122
144PI3K-Akt signaling pathway_Homo sapiens_hsa041510.53408125
145Circadian rhythm_Homo sapiens_hsa047100.52995404
146Salmonella infection_Homo sapiens_hsa051320.52950661
147Proteoglycans in cancer_Homo sapiens_hsa052050.52651280
148Prostate cancer_Homo sapiens_hsa052150.52580974
149TNF signaling pathway_Homo sapiens_hsa046680.52301495
150Leukocyte transendothelial migration_Homo sapiens_hsa046700.52069403
151Tuberculosis_Homo sapiens_hsa051520.51652264
152Adherens junction_Homo sapiens_hsa045200.50986928
153Sphingolipid metabolism_Homo sapiens_hsa006000.50769296
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50506156
155Insulin signaling pathway_Homo sapiens_hsa049100.49684952
156Gap junction_Homo sapiens_hsa045400.49316315
157cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48171929
158Melanogenesis_Homo sapiens_hsa049160.44883859
159AMPK signaling pathway_Homo sapiens_hsa041520.43043806
160Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41212078
161HIF-1 signaling pathway_Homo sapiens_hsa040660.40466350
162Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39732269

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