MFAP3L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1thrombin receptor signaling pathway (GO:0070493)5.73254666
2regulation of lipoprotein metabolic process (GO:0050746)5.01190989
3blood coagulation, intrinsic pathway (GO:0007597)4.96951634
4adenosine receptor signaling pathway (GO:0001973)4.62182872
5regulation of platelet aggregation (GO:0090330)4.57701244
6regulation of platelet activation (GO:0010543)4.27336650
7locomotory exploration behavior (GO:0035641)4.26744831
8positive regulation of endothelial cell differentiation (GO:0045603)4.25458873
9regulation of short-term neuronal synaptic plasticity (GO:0048172)4.25074045
10cellular potassium ion homeostasis (GO:0030007)4.16212734
11neutrophil activation involved in immune response (GO:0002283)4.13825030
12regulation of integrin-mediated signaling pathway (GO:2001044)4.05155381
13synaptic vesicle maturation (GO:0016188)4.03655054
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.03457520
15platelet aggregation (GO:0070527)3.99998349
16negative regulation of norepinephrine secretion (GO:0010700)3.93948183
17long-chain fatty acid biosynthetic process (GO:0042759)3.87507221
18vocalization behavior (GO:0071625)3.86166800
19glutamate secretion (GO:0014047)3.84569991
20protein neddylation (GO:0045116)3.83919223
21plasma membrane fusion (GO:0045026)3.81747728
22leukocyte migration involved in inflammatory response (GO:0002523)3.78606227
23sodium ion export (GO:0071436)3.75342967
24negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.73994980
25positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.65751049
26synaptic vesicle docking involved in exocytosis (GO:0016081)3.63582918
27positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.62996378
28negative regulation of platelet activation (GO:0010544)3.61757552
29synaptic vesicle exocytosis (GO:0016079)3.61357498
30positive regulation of mast cell activation (GO:0033005)3.61321635
31layer formation in cerebral cortex (GO:0021819)3.60571287
32microtubule depolymerization (GO:0007019)3.58710855
33platelet degranulation (GO:0002576)3.58613705
34regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.56080100
35regulation of female receptivity (GO:0045924)3.54966959
36negative regulation of protein localization to cell surface (GO:2000009)3.51378114
37regulation of synaptic vesicle exocytosis (GO:2000300)3.45391413
38angiogenesis involved in wound healing (GO:0060055)3.44944997
39regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.42937056
40neuronal action potential propagation (GO:0019227)3.42241923
41negative regulation of heart contraction (GO:0045822)3.40235498
42relaxation of smooth muscle (GO:0044557)3.38790965
43positive regulation of blood coagulation (GO:0030194)3.37664983
44positive regulation of hemostasis (GO:1900048)3.37664983
45triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.36294221
46negative regulation of inclusion body assembly (GO:0090084)3.36228939
47proline transport (GO:0015824)3.31327358
48regulation of synapse structural plasticity (GO:0051823)3.29511868
49L-amino acid import (GO:0043092)3.28915769
50regulation of glutamate receptor signaling pathway (GO:1900449)3.18798011
51exploration behavior (GO:0035640)3.18341918
52protein localization to synapse (GO:0035418)3.18116212
53neurotransmitter secretion (GO:0007269)3.17962823
54membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.10477725
55neurotransmitter-gated ion channel clustering (GO:0072578)3.09533142
56positive regulation of coagulation (GO:0050820)3.09284023
57polyamine biosynthetic process (GO:0006596)3.06118828
58positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.05905283
59positive regulation of receptor recycling (GO:0001921)3.05884421
60platelet activation (GO:0030168)3.05270982
61regulation of long-term neuronal synaptic plasticity (GO:0048169)3.04105513
62negative regulation of heart rate (GO:0010459)3.02819098
63regulation of synaptic vesicle transport (GO:1902803)3.00511790
64regulation of neuronal synaptic plasticity (GO:0048168)2.97856252
65cerebellar granule cell differentiation (GO:0021707)2.97152860
66ionotropic glutamate receptor signaling pathway (GO:0035235)2.96619137
67microtubule polymerization or depolymerization (GO:0031109)2.95594165
68dendrite morphogenesis (GO:0048813)2.95436901
69cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93937515
70fibrinolysis (GO:0042730)2.93422140
71cell communication by electrical coupling (GO:0010644)2.93143045
72female mating behavior (GO:0060180)2.92406874
73termination of G-protein coupled receptor signaling pathway (GO:0038032)2.91942616
74G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.88953224
75regulation of endothelial cell differentiation (GO:0045601)2.88157792
76regulation of homotypic cell-cell adhesion (GO:0034110)2.87748987
77retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85109516
78lipoxygenase pathway (GO:0019372)2.85106306
79termination of signal transduction (GO:0023021)2.85071769
80potassium ion import (GO:0010107)2.84758273
81beta-amyloid metabolic process (GO:0050435)2.83832065
82cellular sodium ion homeostasis (GO:0006883)2.82325153
83neuron cell-cell adhesion (GO:0007158)2.82180344
84gamma-aminobutyric acid transport (GO:0015812)2.81791212
85amino acid import (GO:0043090)2.80245281
86fatty acid elongation (GO:0030497)2.80232913
87potassium ion homeostasis (GO:0055075)2.77719066
88dendritic spine morphogenesis (GO:0060997)2.77630311
89glutamate receptor signaling pathway (GO:0007215)2.77452053
90regulation of Golgi to plasma membrane protein transport (GO:0042996)2.77232798
91regulation of blood coagulation (GO:0030193)2.76660508
92regulation of hemostasis (GO:1900046)2.76660508
93negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75795153
94homotypic cell-cell adhesion (GO:0034109)2.74853675
95positive regulation of Rho protein signal transduction (GO:0035025)2.74391734
96positive regulation of muscle hypertrophy (GO:0014742)2.74159703
97positive regulation of cardiac muscle hypertrophy (GO:0010613)2.74159703
98response to auditory stimulus (GO:0010996)2.72543589
99regulation of T-helper 2 cell differentiation (GO:0045628)2.70704700
100positive regulation of vesicle fusion (GO:0031340)2.70680884
101regulation of clathrin-mediated endocytosis (GO:2000369)2.70619881
102cytoskeletal anchoring at plasma membrane (GO:0007016)2.68878041
103synaptic transmission, glutamatergic (GO:0035249)2.67611785
104membrane depolarization during action potential (GO:0086010)2.67513366
105neurotransmitter transport (GO:0006836)2.67148384
106negative regulation of blood circulation (GO:1903523)2.65346696
107megakaryocyte development (GO:0035855)2.64446998
108activation of protein kinase A activity (GO:0034199)2.64276941
109protein targeting to Golgi (GO:0000042)2.63594533
110calcium ion-dependent exocytosis (GO:0017156)2.63578196
111regulation of sensory perception of pain (GO:0051930)2.63482449
112regulation of sensory perception (GO:0051931)2.63482449
113regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.63361225
114long-term memory (GO:0007616)2.62161630
115vesicle transport along microtubule (GO:0047496)2.61594649
116negative regulation of catecholamine secretion (GO:0033604)2.60739806
117regulation of synaptic transmission, glutamatergic (GO:0051966)2.60552231
118regulation of cAMP-dependent protein kinase activity (GO:2000479)2.59620663
119positive regulation of systemic arterial blood pressure (GO:0003084)2.59552439
120axonal fasciculation (GO:0007413)2.59547964
121neuron-neuron synaptic transmission (GO:0007270)2.59362432
122mesodermal cell differentiation (GO:0048333)2.59051871
123regulation of dendritic spine morphogenesis (GO:0061001)2.58766385
124relaxation of muscle (GO:0090075)2.58714331
125G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.58193296
126positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.58176123
127negative regulation of hemostasis (GO:1900047)2.58084386
128negative regulation of blood coagulation (GO:0030195)2.58084386
129multicellular organism reproduction (GO:0032504)2.57249655
130establishment of nucleus localization (GO:0040023)2.56948438
131erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.56529358
132L-phenylalanine catabolic process (GO:0006559)2.56529358
133C4-dicarboxylate transport (GO:0015740)2.56336100
134regulation of macrophage derived foam cell differentiation (GO:0010743)2.56281837
135regulation of protein localization to cell surface (GO:2000008)2.55479902
136membrane repolarization (GO:0086009)2.55285324
137acrosome assembly (GO:0001675)2.55233520
138negative regulation of muscle contraction (GO:0045932)2.54892448
139neuron recognition (GO:0008038)2.52739272
140neuromuscular process controlling balance (GO:0050885)2.52494258
141establishment of protein localization to Golgi (GO:0072600)2.52078965
142regulation of synaptic plasticity (GO:0048167)2.51623038
143auditory behavior (GO:0031223)2.51579385
144negative regulation of response to food (GO:0032096)2.51457244
145negative regulation of appetite (GO:0032099)2.51457244
146long-term synaptic potentiation (GO:0060291)2.51258289
147regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.50817284
148neurotransmitter uptake (GO:0001504)2.50063614
149cell communication involved in cardiac conduction (GO:0086065)2.50012467
150postsynaptic membrane organization (GO:0001941)2.49116861
151regulation of coagulation (GO:0050818)2.48936174
152acrosome reaction (GO:0007340)2.48833609
153negative regulation of neural precursor cell proliferation (GO:2000178)2.47885756
154fusion of sperm to egg plasma membrane (GO:0007342)2.47663667
155regulation of excitatory postsynaptic membrane potential (GO:0060079)2.47418023
156alanine transport (GO:0032328)2.47413236
157regulation of vesicle fusion (GO:0031338)2.46757851
158organic cation transport (GO:0015695)2.46379706
159negative regulation of protein localization to plasma membrane (GO:1903077)2.45943076
160negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.45079268
161positive regulation of potassium ion transmembrane transport (GO:1901381)2.44769452
162regulation of norepinephrine secretion (GO:0014061)2.41492587
163regulation of postsynaptic membrane potential (GO:0060078)2.41348255
164positive regulation of wound healing (GO:0090303)2.40977853
165cell wall macromolecule metabolic process (GO:0044036)2.40269746
166cell wall macromolecule catabolic process (GO:0016998)2.40269746
167peripheral nervous system axon ensheathment (GO:0032292)2.40119748
168myelination in peripheral nervous system (GO:0022011)2.40119748
169platelet formation (GO:0030220)2.38826684
170positive regulation of synapse maturation (GO:0090129)2.38443754
171innervation (GO:0060384)2.37411336
172sperm motility (GO:0030317)2.36848203
173regulation of neurotransmitter levels (GO:0001505)2.36778589
174regulation of early endosome to late endosome transport (GO:2000641)2.35932865
175positive regulation of membrane potential (GO:0045838)2.35836626
176purinergic nucleotide receptor signaling pathway (GO:0035590)2.35782310
177chemosensory behavior (GO:0007635)2.35591878
178neuronal ion channel clustering (GO:0045161)2.35163524
179membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.35111354
180glycine transport (GO:0015816)2.34265192
181transmission of nerve impulse (GO:0019226)2.33649461
182regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.32559774
183synapse assembly (GO:0007416)2.31537591
184regulation of neurotransmitter secretion (GO:0046928)2.31020699
185prepulse inhibition (GO:0060134)2.30848693
186synapse organization (GO:0050808)2.30740931
187positive regulation of potassium ion transport (GO:0043268)2.29580843
188G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29098405
189regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.27822592
190cerebellar Purkinje cell differentiation (GO:0021702)2.27546066

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.91790140
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.37243924
3GBX2_23144817_ChIP-Seq_PC3_Human2.65164349
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47766067
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.39969873
6SCL_19346495_ChIP-Seq_HPC-7_Human2.19112984
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18247711
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18247711
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.17947914
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11794216
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11745075
12GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.10977117
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.07307509
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.04104260
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02995611
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95279883
17JARID2_20075857_ChIP-Seq_MESCs_Mouse1.93980629
18DROSHA_22980978_ChIP-Seq_HELA_Human1.91455870
19GATA1_19941826_ChIP-Seq_K562_Human1.90112887
20EZH2_27304074_Chip-Seq_ESCs_Mouse1.86545682
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.82985563
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.78504715
23AR_21572438_ChIP-Seq_LNCaP_Human1.77818401
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.77794135
25EZH2_27294783_Chip-Seq_ESCs_Mouse1.77160641
26RNF2_27304074_Chip-Seq_ESCs_Mouse1.75957561
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.72487522
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71663589
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.71148190
30ESR1_20079471_ChIP-ChIP_T-47D_Human1.70103440
31REST_21632747_ChIP-Seq_MESCs_Mouse1.69778777
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.69598575
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.64522588
34* GATA2_19941826_ChIP-Seq_K562_Human1.63581963
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.61298897
36ZNF217_24962896_ChIP-Seq_MCF-7_Human1.56009911
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.53519898
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.48444690
39GATA1_19941827_ChIP-Seq_MEL_Mouse1.47696135
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.47264364
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.45701611
42GATA1_22025678_ChIP-Seq_K562_Human1.36874826
43PIAS1_25552417_ChIP-Seq_VCAP_Human1.36584344
44IKZF1_21737484_ChIP-ChIP_HCT116_Human1.35014943
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34612748
46* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34557761
47AHR_22903824_ChIP-Seq_MCF-7_Human1.33557737
48ARNT_22903824_ChIP-Seq_MCF-7_Human1.32973913
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32444976
50GATA1_19941827_ChIP-Seq_MEL86_Mouse1.32433244
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.29710355
52CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28945990
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28512947
54HTT_18923047_ChIP-ChIP_STHdh_Human1.28345511
55REST_18959480_ChIP-ChIP_MESCs_Mouse1.27316488
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.27050908
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26356131
58ZNF274_21170338_ChIP-Seq_K562_Hela1.26022446
59AR_25329375_ChIP-Seq_VCAP_Human1.25096334
60EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24822576
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24773397
62KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.24768721
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24745869
64TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.21402988
65CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20405835
66PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.19952614
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.19475253
68TP53_18474530_ChIP-ChIP_U2OS_Human1.18884801
69P300_19829295_ChIP-Seq_ESCs_Human1.18852446
70SPI1_23127762_ChIP-Seq_K562_Human1.18413707
71EP300_21415370_ChIP-Seq_HL-1_Mouse1.18038885
72TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16422510
73PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15751445
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.15473255
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15248610
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.14611286
77RING1B_27294783_Chip-Seq_ESCs_Mouse1.14256491
78RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14188378
79TAF15_26573619_Chip-Seq_HEK293_Human1.14155691
80GF1_26923725_Chip-Seq_HPCs_Mouse1.13564411
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13211774
82SMAD_19615063_ChIP-ChIP_OVARY_Human1.12722653
83NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12704372
84SOX2_21211035_ChIP-Seq_LN229_Gbm1.12323107
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.09258649
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09172809
87TP53_16413492_ChIP-PET_HCT116_Human1.08790410
88ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08478753
89SMAD3_21741376_ChIP-Seq_HESCs_Human1.07754068
90STAT3_23295773_ChIP-Seq_U87_Human1.07620053
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.07283125
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07283125
93AR_19668381_ChIP-Seq_PC3_Human1.06672828
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06370906
95BCAT_22108803_ChIP-Seq_LS180_Human1.04073292
96* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03992346
97TP63_23658742_ChIP-Seq_EP156T_Human1.03416354
98RXR_22108803_ChIP-Seq_LS180_Human1.02184219
99MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02047557
100ER_23166858_ChIP-Seq_MCF-7_Human1.01890810
101ESR2_21235772_ChIP-Seq_MCF-7_Human1.01144161
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00022439
103TBL1_22424771_ChIP-Seq_293T_Human0.99428552
104WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99096959
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98839818
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98669683
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98495162
108YAP1_20516196_ChIP-Seq_MESCs_Mouse0.98176478
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.97891855
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.97099374
111LXR_22158963_ChIP-Seq_LIVER_Mouse0.97020102
112FOXO3_23340844_ChIP-Seq_DLD1_Human0.96648244
113SMAD4_21741376_ChIP-Seq_EPCs_Human0.96527270
114RUNX_20019798_ChIP-Seq_JUKART_Human0.96036724
115E2F1_18555785_Chip-Seq_ESCs_Mouse0.96009992
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95780210
117MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.95738800
118VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.95301553
119BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.94674816
120* MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94470354
121TCF4_23295773_ChIP-Seq_U87_Human0.94352426
122RING1B_27294783_Chip-Seq_NPCs_Mouse0.93880428
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93841770
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.93497514
125P53_22387025_ChIP-Seq_ESCs_Mouse0.92354986
126OCT1_27270436_Chip-Seq_PROSTATE_Human0.92185497
127PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91462986
128NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91026891
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91026891
130BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90721010
131IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90714572
132CBP_20019798_ChIP-Seq_JUKART_Human0.90714572
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.90668576
134CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.90363459
135LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89758855
136P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89539562
137RNF2_27304074_Chip-Seq_NSC_Mouse0.88974843
138TCF4_18268006_ChIP-ChIP_LS174T_Human0.88968539
139GF1B_26923725_Chip-Seq_HPCs_Mouse0.88836423
140EZH2_27294783_Chip-Seq_NPCs_Mouse0.88834831
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.87434324
142KDM2B_26808549_Chip-Seq_K562_Human0.87004894
143NANOG_18555785_Chip-Seq_ESCs_Mouse0.86067288
144POU3F2_20337985_ChIP-ChIP_501MEL_Human0.86049050
145* KDM2B_26808549_Chip-Seq_REH_Human0.86027676
146RUNX2_22187159_ChIP-Seq_PCA_Human0.85931068
147* SALL4_22934838_ChIP-ChIP_CD34+_Human0.85607909
148KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85367231
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84899268
150PPAR_26484153_Chip-Seq_NCI-H1993_Human0.84220725

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology7.41235750
2MP0004859_abnormal_synaptic_plasticity4.90643268
3MP0008004_abnormal_stomach_pH4.51297926
4MP0004510_myositis3.63048045
5MP0000465_gastrointestinal_hemorrhage3.31297326
6MP0004270_analgesia3.20150374
7MP0003635_abnormal_synaptic_transmissio3.05901090
8MP0004084_abnormal_cardiac_muscle2.87560191
9MP0009046_muscle_twitch2.69991050
10MP0009780_abnormal_chondrocyte_physiolo2.63053741
11MP0004858_abnormal_nervous_system2.59294726
12MP0002063_abnormal_learning/memory/cond2.48376691
13MP0001968_abnormal_touch/_nociception2.47259488
14MP0009745_abnormal_behavioral_response2.45338548
15MP0002734_abnormal_mechanical_nocicepti2.31757090
16MP0004036_abnormal_muscle_relaxation2.29372055
17MP0003880_abnormal_central_pattern2.28633910
18MP0002064_seizures2.28056668
19MP0005410_abnormal_fertilization2.26837093
20MP0004885_abnormal_endolymph2.15605220
21MP0004043_abnormal_pH_regulation2.14489537
22MP0003329_amyloid_beta_deposits2.09790831
23MP0001486_abnormal_startle_reflex2.06736302
24MP0003566_abnormal_cell_adhesion2.02909943
25MP0001984_abnormal_olfaction2.02898509
26MP0002572_abnormal_emotion/affect_behav2.02659032
27MP0003724_increased_susceptibility_to1.98116564
28MP0005670_abnormal_white_adipose1.95029148
29MP0002735_abnormal_chemical_nociception1.93649728
30MP0005409_darkened_coat_color1.87334978
31MP0002272_abnormal_nervous_system1.81417511
32MP0002736_abnormal_nociception_after1.79663067
33MP0001440_abnormal_grooming_behavior1.77584677
34MP0000230_abnormal_systemic_arterial1.74640194
35MP0002822_catalepsy1.68976903
36MP0000751_myopathy1.66639672
37MP0005167_abnormal_blood-brain_barrier1.64924160
38MP0008775_abnormal_heart_ventricle1.62246357
39MP0002733_abnormal_thermal_nociception1.62214052
40MP0008569_lethality_at_weaning1.62179411
41MP0002067_abnormal_sensory_capabilities1.58480704
42MP0010234_abnormal_vibrissa_follicle1.58167176
43MP0005623_abnormal_meninges_morphology1.56465993
44MP0001970_abnormal_pain_threshold1.53163033
45MP0001879_abnormal_lymphatic_vessel1.49591913
46MP0001501_abnormal_sleep_pattern1.49253356
47MP0003828_pulmonary_edema1.47083301
48MP0001299_abnormal_eye_distance/1.46729998
49MP0000778_abnormal_nervous_system1.46086102
50MP0005083_abnormal_biliary_tract1.45319674
51MP0005423_abnormal_somatic_nervous1.44921950
52MP0003303_peritoneal_inflammation1.44485052
53MP0002909_abnormal_adrenal_gland1.42797485
54MP0001851_eye_inflammation1.42092155
55MP0000015_abnormal_ear_pigmentation1.40333205
56MP0001958_emphysema1.40170766
57MP0002557_abnormal_social/conspecific_i1.39852651
58MP0003879_abnormal_hair_cell1.36181726
59MP0003633_abnormal_nervous_system1.35666322
60MP0005377_hearing/vestibular/ear_phenot1.34498988
61MP0003878_abnormal_ear_physiology1.34498988
62MP0003638_abnormal_response/metabolism_1.30674816
63MP0001765_abnormal_ion_homeostasis1.30323673
64MP0002184_abnormal_innervation1.30127246
65MP0005646_abnormal_pituitary_gland1.29634792
66MP0000343_altered_response_to1.28273875
67MP0004811_abnormal_neuron_physiology1.24799374
68MP0000569_abnormal_digit_pigmentation1.24210956
69MP0008874_decreased_physiological_sensi1.22779144
70MP0001177_atelectasis1.21295198
71MP0005171_absent_coat_pigmentation1.20867745
72MP0003634_abnormal_glial_cell1.20717047
73MP0003045_fibrosis1.18499245
74MP0002882_abnormal_neuron_morphology1.18344251
75MP0005551_abnormal_eye_electrophysiolog1.17338053
76MP0005386_behavior/neurological_phenoty1.15526439
77MP0004924_abnormal_behavior1.15526439
78MP0003631_nervous_system_phenotype1.15318790
79MP0010329_abnormal_lipoprotein_level1.14540371
80MP0010368_abnormal_lymphatic_system1.12480121
81MP0009384_cardiac_valve_regurgitation1.11499541
82MP0005666_abnormal_adipose_tissue1.11218882
83MP0005248_abnormal_Harderian_gland1.08843656
84MP0001756_abnormal_urination1.08641864
85MP0000955_abnormal_spinal_cord1.07720221
86MP0003300_gastrointestinal_ulcer1.06445547
87MP0000013_abnormal_adipose_tissue1.05033623
88MP0004233_abnormal_muscle_weight1.05014895
89MP0003690_abnormal_glial_cell1.03775009
90MP0000249_abnormal_blood_vessel1.03627953
91MP0004742_abnormal_vestibular_system1.03586267
92MP0002066_abnormal_motor_capabilities/c1.02742237
93MP0003091_abnormal_cell_migration1.02734817
94MP0005174_abnormal_tail_pigmentation1.02140926
95MP0000534_abnormal_ureter_morphology1.01186473
96MP0002796_impaired_skin_barrier0.98618075
97MP0003453_abnormal_keratinocyte_physiol0.98222336
98MP0002090_abnormal_vision0.97253815
99MP0003183_abnormal_peptide_metabolism0.95682328
100MP0008961_abnormal_basal_metabolism0.95391707
101MP0004019_abnormal_vitamin_homeostasis0.94810174
102MP0001502_abnormal_circadian_rhythm0.94283994
103MP0006276_abnormal_autonomic_nervous0.93676147
104MP0005023_abnormal_wound_healing0.92329069
105MP0003656_abnormal_erythrocyte_physiolo0.92037908
106MP0010386_abnormal_urinary_bladder0.91715535
107MP0003632_abnormal_nervous_system0.91540203
108MP0001485_abnormal_pinna_reflex0.89882835
109MP0000920_abnormal_myelination0.89469510
110MP0002972_abnormal_cardiac_muscle0.88094919
111MP0004947_skin_inflammation0.86591036
112MP0004381_abnormal_hair_follicle0.85494975
113MP0000604_amyloidosis0.84590773
114MP0005058_abnormal_lysosome_morphology0.84421797
115MP0008872_abnormal_physiological_respon0.83964910
116MP0004484_altered_response_of0.83948513
117MP0003698_abnormal_male_reproductive0.83476274
118MP0002229_neurodegeneration0.83193069
119MP0003283_abnormal_digestive_organ0.82299339
120MP0002234_abnormal_pharynx_morphology0.82273798
121MP0004215_abnormal_myocardial_fiber0.82105687
122MP0005535_abnormal_body_temperature0.82097762
123MP0002152_abnormal_brain_morphology0.81821973
124MP0005275_abnormal_skin_tensile0.81784016
125MP0003011_delayed_dark_adaptation0.80509484
126MP0001929_abnormal_gametogenesis0.79983781
127MP0001963_abnormal_hearing_physiology0.79458013
128MP0003718_maternal_effect0.79418061
129MP0002896_abnormal_bone_mineralization0.78926732
130MP0000747_muscle_weakness0.78004738
131MP0004272_abnormal_basement_membrane0.77474508
132MP0004145_abnormal_muscle_electrophysio0.77192763
133MP0002118_abnormal_lipid_homeostasis0.73557066
134MP0005620_abnormal_muscle_contractility0.72749418
135MP0006138_congestive_heart_failure0.72453137
136MP0005499_abnormal_olfactory_system0.70823647
137MP0005394_taste/olfaction_phenotype0.70823647
138MP0005187_abnormal_penis_morphology0.69719593
139MP0009053_abnormal_anal_canal0.69690881
140MP0002752_abnormal_somatic_nervous0.69469005
141MP0003075_altered_response_to0.68801066
142MP0010678_abnormal_skin_adnexa0.68406688
143MP0009697_abnormal_copulation0.65596348
144MP0004085_abnormal_heartbeat0.65032497
145MP0001905_abnormal_dopamine_level0.64830874
146MP0003136_yellow_coat_color0.64579689
147MP0005165_increased_susceptibility_to0.64063687
148MP0000579_abnormal_nail_morphology0.64052376
149MP0002089_abnormal_postnatal_growth/wei0.63381991
150MP0002998_abnormal_bone_remodeling0.62497052
151MP0000749_muscle_degeneration0.62166407
152MP0004130_abnormal_muscle_cell0.61781381
153MP0000631_abnormal_neuroendocrine_gland0.60612139
154MP0002168_other_aberrant_phenotype0.60256369

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)9.27627969
2Prolonged bleeding time (HP:0003010)9.04224015
3Menorrhagia (HP:0000132)8.95383292
4Abnormal platelet volume (HP:0011876)8.60411490
5Petechiae (HP:0000967)7.70789898
6Purpura (HP:0000979)7.55620479
7Gingival bleeding (HP:0000225)6.45521911
8Epistaxis (HP:0000421)6.09501236
9Abnormal platelet function (HP:0011869)4.86744737
10Impaired platelet aggregation (HP:0003540)4.86744737
11Hyperlipoproteinemia (HP:0010980)4.60677148
12Focal motor seizures (HP:0011153)4.47770171
13Action tremor (HP:0002345)4.07354486
14Poikilocytosis (HP:0004447)3.92281976
15Myokymia (HP:0002411)3.91788263
16Spontaneous hematomas (HP:0007420)3.82138819
17Acanthocytosis (HP:0001927)3.57208712
18Increased circulating renin level (HP:0000848)3.52984951
19Ulnar claw (HP:0001178)3.52703513
20Conjunctival telangiectasia (HP:0000524)3.45021474
21Focal seizures (HP:0007359)3.42272724
22Aplasia involving bones of the extremities (HP:0009825)3.34593914
23Aplasia involving bones of the upper limbs (HP:0009823)3.34593914
24Aplasia of the phalanges of the hand (HP:0009802)3.34593914
25Metabolic alkalosis (HP:0200114)3.30263502
26Abnormality of the common coagulation pathway (HP:0010990)3.29793497
27Insidious onset (HP:0003587)3.23535068
28Termporal pattern (HP:0011008)3.23535068
29Papillary thyroid carcinoma (HP:0002895)3.20726297
30Hypokalemic alkalosis (HP:0001949)3.09553471
31Absent/shortened dynein arms (HP:0200106)2.99872603
32Dynein arm defect of respiratory motile cilia (HP:0012255)2.99872603
33Hypomagnesemia (HP:0002917)2.95698300
34Abnormal pupillary function (HP:0007686)2.90504684
35Abnormal auditory evoked potentials (HP:0006958)2.89415960
36Abnormality of the vasculature of the conjunctiva (HP:0008054)2.83431124
37Progressive cerebellar ataxia (HP:0002073)2.75188237
38Bruising susceptibility (HP:0000978)2.73814528
39Visual hallucinations (HP:0002367)2.73091191
40Epileptic encephalopathy (HP:0200134)2.72670815
41Polyuria (HP:0000103)2.68966594
42Abnormality of renal excretion (HP:0011036)2.63751291
43Megalencephaly (HP:0001355)2.62737979
44Hyperactive renin-angiotensin system (HP:0000841)2.60752515
45Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.60688704
46Abnormal urine output (HP:0012590)2.60061437
47Polydipsia (HP:0001959)2.59573794
48Abnormal drinking behavior (HP:0030082)2.59573794
49Dyschromatopsia (HP:0007641)2.58556290
50Fetal akinesia sequence (HP:0001989)2.53108808
51Segmental peripheral demyelination/remyelination (HP:0003481)2.48383943
52Upper limb muscle weakness (HP:0003484)2.43548399
53Neurofibrillary tangles (HP:0002185)2.38888890
54Joint hemorrhage (HP:0005261)2.38666463
55Dysdiadochokinesis (HP:0002075)2.35818335
56Abnormality of magnesium homeostasis (HP:0004921)2.35304765
57Supranuclear gaze palsy (HP:0000605)2.33888019
58Abnormal eating behavior (HP:0100738)2.31602304
59Absence seizures (HP:0002121)2.30337578
60Cerebral inclusion bodies (HP:0100314)2.29782284
61Male infertility (HP:0003251)2.28031264
62Gout (HP:0001997)2.26867685
63Spontaneous abortion (HP:0005268)2.26817060
64Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.24063761
65Atonic seizures (HP:0010819)2.23364644
66Hyperventilation (HP:0002883)2.23269655
67Generalized tonic-clonic seizures (HP:0002069)2.20593226
68Abnormality of chloride homeostasis (HP:0011422)2.18560725
69Abnormal respiratory motile cilium physiology (HP:0012261)2.16152323
70Truncal ataxia (HP:0002078)2.15523981
71Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.14554844
72Ankle clonus (HP:0011448)2.10800222
73Hyperaldosteronism (HP:0000859)2.10083348
74Postural instability (HP:0002172)2.09782470
75Febrile seizures (HP:0002373)2.06865347
76Dialeptic seizures (HP:0011146)2.02737389
77Resting tremor (HP:0002322)2.02432613
78Broad-based gait (HP:0002136)2.00176113
79Intention tremor (HP:0002080)1.98262843
80Decreased central vision (HP:0007663)1.96560223
81Urinary urgency (HP:0000012)1.96048226
82Tubular atrophy (HP:0000092)1.95346753
83Paralysis (HP:0003470)1.94748518
84Xanthomatosis (HP:0000991)1.93411264
85Onion bulb formation (HP:0003383)1.93010697
86Abnormality of renin-angiotensin system (HP:0000847)1.92791249
87Depression (HP:0000716)1.92140569
88Hyporeflexia of lower limbs (HP:0002600)1.91502706
89Generalized aminoaciduria (HP:0002909)1.89358210
90Impaired vibration sensation in the lower limbs (HP:0002166)1.88454451
91Increased density of long bones (HP:0006392)1.87329197
92Tubulointerstitial fibrosis (HP:0005576)1.86441135
93Hypoplasia of the iris (HP:0007676)1.86147618
94Hammertoe (HP:0001765)1.85426401
95Bronchomalacia (HP:0002780)1.85330120
96Gaze-evoked nystagmus (HP:0000640)1.84894218
97Menstrual irregularities (HP:0000858)1.83623448
98Papilledema (HP:0001085)1.81312095
99Degeneration of the lateral corticospinal tracts (HP:0002314)1.81021056
100Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.81021056
101Leiomyosarcoma (HP:0100243)1.80509252
102Uterine leiomyosarcoma (HP:0002891)1.80509252
103Akinesia (HP:0002304)1.79168902
104Abnormal ciliary motility (HP:0012262)1.79034779
105Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.78434913
106Genetic anticipation (HP:0003743)1.78373247
107Urinary bladder sphincter dysfunction (HP:0002839)1.78113870
108Choroideremia (HP:0001139)1.77925538
109Renal salt wasting (HP:0000127)1.77870614
110Mitral stenosis (HP:0001718)1.77674297
111Peripheral hypomyelination (HP:0007182)1.77582680
112Postural tremor (HP:0002174)1.77230198
113Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.76753443
114Hemiparesis (HP:0001269)1.76358577
115Potter facies (HP:0002009)1.75979507
116Facial shape deformation (HP:0011334)1.75979507
117Infertility (HP:0000789)1.75539100
118Steppage gait (HP:0003376)1.74644121
119Mutism (HP:0002300)1.74416982
120Transitional cell carcinoma of the bladder (HP:0006740)1.74311395
121Abnormality of the fovea (HP:0000493)1.73579951
122Diplopia (HP:0000651)1.73423696
123Abnormality of binocular vision (HP:0011514)1.73423696
124Abnormality of lateral ventricle (HP:0030047)1.72405705
125Thyroid carcinoma (HP:0002890)1.70863167
126Excessive salivation (HP:0003781)1.70693365
127Drooling (HP:0002307)1.70693365
128Abnormal large intestine physiology (HP:0012700)1.70320539
129Spastic gait (HP:0002064)1.69735740
130Tetany (HP:0001281)1.69684627
131Blue irides (HP:0000635)1.68598619
132Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68369936
133Dysmetria (HP:0001310)1.67376297
134Ventricular fibrillation (HP:0001663)1.67236743
135Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.66258445
136Overgrowth (HP:0001548)1.65620676
137Bundle branch block (HP:0011710)1.65378282
138Hyperkalemia (HP:0002153)1.65061058
139Neonatal short-limb short stature (HP:0008921)1.63824954
140Abnormality of potassium homeostasis (HP:0011042)1.63296152
141Adrenal overactivity (HP:0002717)1.63126064
142Increased CSF protein (HP:0002922)1.62893898
143Abnormality of calcium-phosphate metabolism (HP:0100530)1.62195817
144Decreased motor nerve conduction velocity (HP:0003431)1.62058068
145Anxiety (HP:0000739)1.61607216
146Impaired vibratory sensation (HP:0002495)1.61593072
147Impaired social interactions (HP:0000735)1.60627311
148Abnormal social behavior (HP:0012433)1.60627311
149Atrophic scars (HP:0001075)1.60173532
150Obstructive sleep apnea (HP:0002870)1.59904920
151Foot dorsiflexor weakness (HP:0009027)1.59477445
152Portal hypertension (HP:0001409)1.58212029
153Bladder carcinoma (HP:0002862)1.58078406
154Bladder neoplasm (HP:0009725)1.58078406
155Hyperthyroidism (HP:0000836)1.57530287
156Scotoma (HP:0000575)1.55946344
157Hypophosphatemic rickets (HP:0004912)1.55777986
158Lower limb amyotrophy (HP:0007210)1.55287581
159Tinnitus (HP:0000360)1.53774442
160Joint swelling (HP:0001386)1.52958967
161Arterial thrombosis (HP:0004420)1.52754167
162Abnormality of the corticospinal tract (HP:0002492)1.52369621
163Bowel incontinence (HP:0002607)1.52292992
164Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.50880583
165Abnormality of the heme biosynthetic pathway (HP:0010472)1.50727968
166Distal lower limb amyotrophy (HP:0008944)1.46342810
167Testicular neoplasm (HP:0010788)1.45748679
168Vertigo (HP:0002321)1.45242078
169Abnormality of sodium homeostasis (HP:0010931)1.44059478
170Myocardial infarction (HP:0001658)1.43852837
171Rickets (HP:0002748)1.42800160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BMX3.27609311
2NTRK33.07884338
3EPHA43.07765968
4PRKD32.80215453
5MST42.73635668
6MAP3K92.72474682
7PIK3CG2.69986454
8MYLK2.67198960
9WNK42.54434660
10PDK32.50777130
11PDK42.50777130
12MARK12.35289828
13OXSR12.32464702
14EIF2AK12.23455544
15MINK12.12263973
16MAP3K42.10342218
17STK392.02735098
18TEC1.88576922
19PAK61.87112075
20STK381.84212478
21NTRK21.83975308
22LMTK21.83148665
23NTRK11.78643149
24WNK31.72735754
25STK31.68671832
26DAPK21.67352497
27MAP3K21.64279372
28BMPR21.61136198
29PDK21.57476971
30KSR21.47846199
31CAMKK11.47516113
32LATS21.47175221
33SYK1.43245504
34MAP2K71.39775323
35CASK1.37549823
36PHKG21.34261640
37PHKG11.34261640
38RIPK41.33907476
39BTK1.33400697
40TRIB31.31082499
41PAK31.28817478
42MAP2K41.27467245
43PTK2B1.25896865
44CDK51.24875259
45FER1.23490006
46PLK41.23472174
47FGR1.22936434
48TESK11.18261552
49PLK21.11894203
50LATS11.11841495
51RIPK11.11765371
52ZAP701.08514773
53WNK11.07562725
54SGK4941.06909878
55SGK2231.06909878
56CSF1R1.04353305
57TYRO31.03589721
58ARAF1.01763012
59KSR10.98530571
60INSRR0.96658179
61RET0.96441374
62NEK60.94754312
63DDR20.92895464
64PINK10.92199093
65FRK0.91689988
66HCK0.90603478
67MUSK0.88174970
68PRKCG0.88116661
69PKN10.87451414
70MAPK120.86704203
71PDGFRB0.85596882
72MAP3K120.83291269
73SGK30.83266946
74ILK0.80835146
75TAOK30.80574935
76GRK50.80222768
77SGK20.79925245
78FGFR20.79799040
79DMPK0.79711722
80CAMKK20.79424178
81PDPK10.78975010
82MARK20.78553246
83CAMK2A0.77960711
84ERBB20.76998804
85MET0.75366237
86GRK60.75107351
87MAP2K10.74597196
88FES0.74564239
89TNIK0.74115327
90MAP3K10.73683384
91CDK140.73108394
92CDK150.71274607
93PRKG10.70708205
94CDK180.70501768
95STK38L0.70070390
96PDK10.69487198
97STK110.69372293
98MOS0.68433157
99SGK10.68065570
100ROCK10.67383467
101SCYL20.67146114
102PAK10.64483238
103PTK20.64366055
104MAP3K30.63899933
105CSNK1G20.63449743
106PRKD10.63297985
107MAPK130.61355503
108MST1R0.60101579
109CAMK1G0.59701143
110TAOK10.58794428
111MAP3K70.57501860
112YES10.57360387
113CDK11A0.57307938
114BLK0.57235593
115PRKCE0.57091668
116ROCK20.55585814
117PNCK0.54927389
118PRKCH0.54874997
119MARK30.54419466
120NEK10.53923661
121TTN0.53018685
122TNK20.52783407
123PRPF4B0.52766713
124JAK20.52317918
125MAP3K50.51722368
126CDC42BPA0.49554047
127CAMK10.49128812
128DAPK10.48062160
129CDK190.47994679
130EPHB20.47333436
131ERBB30.45794679
132PDGFRA0.45387834
133RAF10.44480915
134ICK0.44273447
135DYRK1A0.43928909
136LIMK10.43691937
137PRKACG0.42922412
138NEK90.42089714
139PRKCZ0.41741167
140FYN0.41601755
141DAPK30.41526409
142STK240.39439243
143AKT30.39386777
144SIK20.38790282
145CAMK2G0.37942319
146CAMK2B0.37438155
147PRKCB0.36992562

Predicted pathways (KEGG)

RankGene SetZ-score
1Platelet activation_Homo sapiens_hsa046113.59403141
2Synaptic vesicle cycle_Homo sapiens_hsa047212.56348658
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.37757744
4Nicotine addiction_Homo sapiens_hsa050332.30407645
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28321594
6Salivary secretion_Homo sapiens_hsa049702.00506362
7Olfactory transduction_Homo sapiens_hsa047401.98847806
8Gastric acid secretion_Homo sapiens_hsa049711.96965610
9Circadian entrainment_Homo sapiens_hsa047131.91988834
10Long-term potentiation_Homo sapiens_hsa047201.91084324
11Glutamatergic synapse_Homo sapiens_hsa047241.84896529
12Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.84323480
13GABAergic synapse_Homo sapiens_hsa047271.79875971
14Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.79602579
15Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.73414822
16Collecting duct acid secretion_Homo sapiens_hsa049661.71754110
17Nitrogen metabolism_Homo sapiens_hsa009101.70244379
18Amphetamine addiction_Homo sapiens_hsa050311.68159809
19Morphine addiction_Homo sapiens_hsa050321.58411503
20Insulin secretion_Homo sapiens_hsa049111.51619772
21Dopaminergic synapse_Homo sapiens_hsa047281.48483579
22Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48145695
23Renin secretion_Homo sapiens_hsa049241.45651669
24Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.41278496
25Fatty acid biosynthesis_Homo sapiens_hsa000611.39405229
26SNARE interactions in vesicular transport_Homo sapiens_hsa041301.39014483
27Cholinergic synapse_Homo sapiens_hsa047251.38706669
28Taste transduction_Homo sapiens_hsa047421.26453349
29Oxytocin signaling pathway_Homo sapiens_hsa049211.24880799
30Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24099878
31GnRH signaling pathway_Homo sapiens_hsa049121.21985681
32Dorso-ventral axis formation_Homo sapiens_hsa043201.18616296
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.17541775
34Arachidonic acid metabolism_Homo sapiens_hsa005901.16085589
35Calcium signaling pathway_Homo sapiens_hsa040201.16012137
36Long-term depression_Homo sapiens_hsa047301.15765354
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.15330263
38beta-Alanine metabolism_Homo sapiens_hsa004101.12489740
39Mineral absorption_Homo sapiens_hsa049781.10882849
40Cocaine addiction_Homo sapiens_hsa050301.10504090
41Serotonergic synapse_Homo sapiens_hsa047261.09365707
42Axon guidance_Homo sapiens_hsa043601.09057658
43Phototransduction_Homo sapiens_hsa047441.08113408
44Gap junction_Homo sapiens_hsa045401.07494518
45cAMP signaling pathway_Homo sapiens_hsa040241.06763451
46Glioma_Homo sapiens_hsa052141.04405223
47Thyroid hormone synthesis_Homo sapiens_hsa049181.03123682
48Chemokine signaling pathway_Homo sapiens_hsa040621.02896432
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.02862014
50Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02604111
51Dilated cardiomyopathy_Homo sapiens_hsa054141.01967022
52Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01124578
53Estrogen signaling pathway_Homo sapiens_hsa049151.00446308
54Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96309461
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95506001
56cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93594496
57Histidine metabolism_Homo sapiens_hsa003400.93472798
58Bile secretion_Homo sapiens_hsa049760.93384730
59Melanogenesis_Homo sapiens_hsa049160.92451481
60Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92303554
61Vibrio cholerae infection_Homo sapiens_hsa051100.90359811
62Non-small cell lung cancer_Homo sapiens_hsa052230.90219073
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.88569304
64Complement and coagulation cascades_Homo sapiens_hsa046100.87645280
65Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85909377
66Adherens junction_Homo sapiens_hsa045200.85779211
67ErbB signaling pathway_Homo sapiens_hsa040120.85495586
68Pancreatic secretion_Homo sapiens_hsa049720.82286755
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.79825360
70Butanoate metabolism_Homo sapiens_hsa006500.78697252
71Tight junction_Homo sapiens_hsa045300.78342302
72Phospholipase D signaling pathway_Homo sapiens_hsa040720.78254776
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78199569
74Cardiac muscle contraction_Homo sapiens_hsa042600.77913299
75Glycerophospholipid metabolism_Homo sapiens_hsa005640.75728530
76Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75685542
77Type II diabetes mellitus_Homo sapiens_hsa049300.75084087
78Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.73968594
79Choline metabolism in cancer_Homo sapiens_hsa052310.72669510
80Glucagon signaling pathway_Homo sapiens_hsa049220.71852979
81Retinol metabolism_Homo sapiens_hsa008300.70991371
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70861783
83Alcoholism_Homo sapiens_hsa050340.70771171
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.70594868
85Primary bile acid biosynthesis_Homo sapiens_hsa001200.69095763
86B cell receptor signaling pathway_Homo sapiens_hsa046620.68814851
87Rap1 signaling pathway_Homo sapiens_hsa040150.68574360
88Hematopoietic cell lineage_Homo sapiens_hsa046400.68402419
89PPAR signaling pathway_Homo sapiens_hsa033200.66595360
90VEGF signaling pathway_Homo sapiens_hsa043700.66517088
91Linoleic acid metabolism_Homo sapiens_hsa005910.65134340
92Arginine and proline metabolism_Homo sapiens_hsa003300.64909098
93Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.63795524
94Steroid hormone biosynthesis_Homo sapiens_hsa001400.63021842
95Pancreatic cancer_Homo sapiens_hsa052120.62990614
96Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62839289
97Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61811185
98Renal cell carcinoma_Homo sapiens_hsa052110.61769601
99Amoebiasis_Homo sapiens_hsa051460.61561056
100ABC transporters_Homo sapiens_hsa020100.60161816
101Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.60045520
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.59380645
103Tyrosine metabolism_Homo sapiens_hsa003500.58441155
104Ras signaling pathway_Homo sapiens_hsa040140.57027910
105Endometrial cancer_Homo sapiens_hsa052130.56210255
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56081003
107Focal adhesion_Homo sapiens_hsa045100.56050010
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55878829
109Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55499251
110Phenylalanine metabolism_Homo sapiens_hsa003600.53737186
111ECM-receptor interaction_Homo sapiens_hsa045120.53225363
112Endocytosis_Homo sapiens_hsa041440.52083874
113Circadian rhythm_Homo sapiens_hsa047100.51624699
114MAPK signaling pathway_Homo sapiens_hsa040100.51012050
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.50905684
116Caffeine metabolism_Homo sapiens_hsa002320.50264948
117Protein digestion and absorption_Homo sapiens_hsa049740.49936224
118Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49871698
119Hedgehog signaling pathway_Homo sapiens_hsa043400.49589913
120Hippo signaling pathway_Homo sapiens_hsa043900.49178481
121Ovarian steroidogenesis_Homo sapiens_hsa049130.48973335
122Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48713029
123Proteoglycans in cancer_Homo sapiens_hsa052050.48629186
124Fatty acid metabolism_Homo sapiens_hsa012120.48570571
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48161866
126Inositol phosphate metabolism_Homo sapiens_hsa005620.47864699
127Pyruvate metabolism_Homo sapiens_hsa006200.46745401
128mTOR signaling pathway_Homo sapiens_hsa041500.45831591
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44882170
130Melanoma_Homo sapiens_hsa052180.44588793
131Oocyte meiosis_Homo sapiens_hsa041140.43924344
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.43300240
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.42595150
134Glycerolipid metabolism_Homo sapiens_hsa005610.42552006
135Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.42241121

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