MFAP5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 25-kD microfibril-associated glycoprotein which is a component of microfibrils of the extracellular matrix. The encoded protein promotes attachment of cells to microfibrils via alpha-V-beta-3 integrin. Deficiency of this gene in mice results in neutropenia. Alternate splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.14307879
2peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)7.51408845
3collagen fibril organization (GO:0030199)7.34740679
4positive regulation of osteoblast proliferation (GO:0033690)7.04860039
5dermatan sulfate biosynthetic process (GO:0030208)6.79142266
6keratan sulfate catabolic process (GO:0042340)6.51934672
7sequestering of extracellular ligand from receptor (GO:0035581)6.38518988
8dermatan sulfate metabolic process (GO:0030205)6.22096144
9bone trabecula formation (GO:0060346)6.07699046
10* extracellular fibril organization (GO:0043206)5.54495805
11opsonization (GO:0008228)5.24225210
12nucleotide-sugar biosynthetic process (GO:0009226)5.10703154
13UDP-N-acetylglucosamine metabolic process (GO:0006047)5.04516717
14negative regulation of complement activation (GO:0045916)4.92753263
15* fibril organization (GO:0097435)4.92217110
16venous blood vessel morphogenesis (GO:0048845)4.80831477
17negative regulation of chondrocyte differentiation (GO:0032331)4.52731398
18hemidesmosome assembly (GO:0031581)4.52531231
19kidney mesenchyme development (GO:0072074)4.46090902
20collagen metabolic process (GO:0032963)4.46055428
21cell migration involved in heart development (GO:0060973)4.41064014
22skin morphogenesis (GO:0043589)4.40785300
23chondroitin sulfate catabolic process (GO:0030207)4.40568714
24extracellular matrix assembly (GO:0085029)4.39990658
25regulation of macrophage cytokine production (GO:0010935)4.32311725
26collagen catabolic process (GO:0030574)4.25133941
27regulation of integrin-mediated signaling pathway (GO:2001044)4.25094212
28regulation of cardiac muscle cell apoptotic process (GO:0010665)4.22108381
29multicellular organismal macromolecule metabolic process (GO:0044259)4.19988965
30positive regulation of macrophage cytokine production (GO:0060907)4.19567730
31protein retention in ER lumen (GO:0006621)4.13242785
32type B pancreatic cell proliferation (GO:0044342)4.12228759
33negative regulation of cartilage development (GO:0061037)4.08976040
34multicellular organismal metabolic process (GO:0044236)4.02418252
35mesenchymal-epithelial cell signaling (GO:0060638)3.99371101
36cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.96016925
37negative regulation of protein activation cascade (GO:2000258)3.92991959
38multicellular organismal catabolic process (GO:0044243)3.92859102
39lymph vessel development (GO:0001945)3.91945953
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.86093231
41polyketide metabolic process (GO:0030638)3.82403900
42doxorubicin metabolic process (GO:0044598)3.82403900
43daunorubicin metabolic process (GO:0044597)3.82403900
44endothelial cell morphogenesis (GO:0001886)3.80385167
45extracellular matrix disassembly (GO:0022617)3.77982118
46chondroitin sulfate biosynthetic process (GO:0030206)3.75855264
47regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.72380514
48chondrocyte proliferation (GO:0035988)3.70522602
49regulation of striated muscle cell apoptotic process (GO:0010662)3.70021194
50cell adhesion mediated by integrin (GO:0033627)3.68393566
51regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.62499949
52regulation of osteoblast proliferation (GO:0033688)3.56511246
53protein localization to cell surface (GO:0034394)3.55601061
54negative regulation of heart growth (GO:0061117)3.54145953
55negative regulation of cardiac muscle tissue growth (GO:0055022)3.54145953
56negative regulation of smooth muscle cell migration (GO:0014912)3.53388077
57atrioventricular valve morphogenesis (GO:0003181)3.49943264
58establishment of planar polarity (GO:0001736)3.45619501
59establishment of tissue polarity (GO:0007164)3.45619501
60cellular response to vitamin (GO:0071295)3.44165003
61negative regulation of muscle hypertrophy (GO:0014741)3.42940447
62retina vasculature morphogenesis in camera-type eye (GO:0061299)3.41310369
63endodermal cell differentiation (GO:0035987)3.40987292
64chondrocyte development (GO:0002063)3.40534629
65* extracellular matrix organization (GO:0030198)3.40223654
66* extracellular structure organization (GO:0043062)3.38877829
67negative regulation of humoral immune response (GO:0002921)3.37519602
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.37016967
69cell-substrate junction assembly (GO:0007044)3.36629240
70substrate adhesion-dependent cell spreading (GO:0034446)3.35321195
71negative regulation of nitric-oxide synthase activity (GO:0051001)3.35161797
72endocardial cushion morphogenesis (GO:0003203)3.33493202
73regulation of cell migration involved in sprouting angiogenesis (GO:0090049)3.32051060
74extracellular negative regulation of signal transduction (GO:1900116)3.31277088
75extracellular regulation of signal transduction (GO:1900115)3.31277088
76positive regulation of blood vessel endothelial cell migration (GO:0043536)3.28634238
77glomerular basement membrane development (GO:0032836)3.25812784
78regulation of establishment of planar polarity (GO:0090175)3.25788732
79regulation of plasminogen activation (GO:0010755)3.24864079
80protein trimerization (GO:0070206)3.24084834
81smooth muscle tissue development (GO:0048745)3.22113834
82stress fiber assembly (GO:0043149)3.20436463
83negative regulation of BMP signaling pathway (GO:0030514)3.19961370
84negative regulation of biomineral tissue development (GO:0070168)3.19310255
85negative regulation of protein localization to cell surface (GO:2000009)3.18765184
86vitamin A metabolic process (GO:0006776)3.18474456
87glycosaminoglycan catabolic process (GO:0006027)3.16921268
88peptidyl-proline hydroxylation (GO:0019511)3.15765038
89positive regulation of Rho protein signal transduction (GO:0035025)3.14698979
90substrate-dependent cell migration (GO:0006929)3.12591240
91vascular endothelial growth factor signaling pathway (GO:0038084)3.12554467
92cyclooxygenase pathway (GO:0019371)3.12379842
93regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.08947241
94embryonic cranial skeleton morphogenesis (GO:0048701)3.08803642
95sulfur compound catabolic process (GO:0044273)3.07455004
96negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.07362482
97negative regulation of nitric oxide biosynthetic process (GO:0045019)3.05712158
98actin-mediated cell contraction (GO:0070252)3.05569740
99trabecula formation (GO:0060343)3.04717760
100cardiac epithelial to mesenchymal transition (GO:0060317)3.04535211
101positive regulation of endothelial cell apoptotic process (GO:2000353)3.00327798
102glomerulus development (GO:0032835)3.00120753
103regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.99729507
104basement membrane organization (GO:0071711)2.99705681
105virion attachment to host cell (GO:0019062)2.99006369
106adhesion of symbiont to host cell (GO:0044650)2.99006369
107aminoglycan catabolic process (GO:0006026)2.98620185
108craniofacial suture morphogenesis (GO:0097094)2.98456421
109barbed-end actin filament capping (GO:0051016)2.98428520
110blood vessel maturation (GO:0001955)2.96638008
111pericardium development (GO:0060039)2.95474413
112regulation of SMAD protein import into nucleus (GO:0060390)2.95260000
113cranial suture morphogenesis (GO:0060363)2.95161977
114negative regulation of cardiac muscle hypertrophy (GO:0010614)2.92091293
115positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.91848295
116actin-myosin filament sliding (GO:0033275)2.90626608
117muscle filament sliding (GO:0030049)2.90626608
118mesenchyme morphogenesis (GO:0072132)2.90084835
119regulation of chondrocyte differentiation (GO:0032330)2.89778607
120non-canonical Wnt signaling pathway (GO:0035567)2.89663473
121fibroblast migration (GO:0010761)2.89582444
122regulation of cardiac muscle cell differentiation (GO:2000725)2.89016959
123regulation of cartilage development (GO:0061035)2.88758553
124regulation of muscle hypertrophy (GO:0014743)2.87886558
125gonadal mesoderm development (GO:0007506)2.86516869
126regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.86436834
127negative regulation of cardiac muscle tissue development (GO:0055026)2.86275314
128protein targeting to plasma membrane (GO:0072661)2.85763648
129cellular response to amino acid stimulus (GO:0071230)2.83695039
130wound healing (GO:0042060)2.83567561
131metanephric mesenchyme development (GO:0072075)2.81737128
132peptide cross-linking (GO:0018149)2.80508295
133positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.79915458
134middle ear morphogenesis (GO:0042474)2.79490997
135positive regulation of fatty acid oxidation (GO:0046321)2.79467156
136wound healing, spreading of epidermal cells (GO:0035313)2.78787048
137cardiac myofibril assembly (GO:0055003)2.78405430
138cochlea morphogenesis (GO:0090103)2.78362536
139regulation of odontogenesis (GO:0042481)2.77626709
140ovulation from ovarian follicle (GO:0001542)2.77244684
141glycosaminoglycan biosynthetic process (GO:0006024)2.76990154
142response to gravity (GO:0009629)2.76744397
143keratan sulfate metabolic process (GO:0042339)2.76554422
144cell-matrix adhesion (GO:0007160)2.75463337
145nucleotide-sugar metabolic process (GO:0009225)2.74743747
146aminoglycan biosynthetic process (GO:0006023)2.74375772
147negative regulation of fatty acid transport (GO:2000192)2.73323137
148membrane raft organization (GO:0031579)2.72855233
149plasma membrane repair (GO:0001778)2.72262109
150lymphangiogenesis (GO:0001946)2.70752264
151cell-substrate adhesion (GO:0031589)2.69013159
152sprouting angiogenesis (GO:0002040)2.68856000
153regulation of phospholipase A2 activity (GO:0032429)2.68744538
154regulation of cardiac muscle hypertrophy (GO:0010611)2.68167471
155negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway (GO:2.67956730
156regulation of apoptotic process involved in morphogenesis (GO:1902337)2.67934750
157pathway-restricted SMAD protein phosphorylation (GO:0060389)2.67833849
158positive regulation of fibroblast migration (GO:0010763)2.65588893
159dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65578727
160regulation of smooth muscle cell migration (GO:0014910)2.62465654
161regulation of chemokine-mediated signaling pathway (GO:0070099)2.61352433
162actin filament depolymerization (GO:0030042)2.60322499
163positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)2.60167653

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.67779055
2RARG_19884340_ChIP-ChIP_MEFs_Mouse5.06633158
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.34019894
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.28859765
5TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human3.19175015
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.89463151
7CJUN_26792858_Chip-Seq_BT549_Human2.87824087
8CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.78482456
9CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.77148767
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.70601323
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.53163149
12KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.47903847
13KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.47903847
14KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.47903847
15BP1_19119308_ChIP-ChIP_Hs578T_Human2.43588870
16CLOCK_20551151_ChIP-Seq_293T_Human2.41878020
17WT1_19549856_ChIP-ChIP_CCG9911_Human2.37596781
18ESR1_21235772_ChIP-Seq_MCF-7_Human2.34920781
19HIF1A_21447827_ChIP-Seq_MCF-7_Human2.26274323
20EP300_21415370_ChIP-Seq_HL-1_Mouse2.10592204
21BRD4_25478319_ChIP-Seq_HGPS_Human2.01724733
22GATA2_21666600_ChIP-Seq_HMVEC_Human1.98787694
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.97461413
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.94837948
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.93698215
26NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.90466561
27NRF2_20460467_ChIP-Seq_MEFs_Mouse1.90466561
28ESR2_21235772_ChIP-Seq_MCF-7_Human1.88177627
29GBX2_23144817_ChIP-Seq_PC3_Human1.79518575
30PPAR_26484153_Chip-Seq_NCI-H1993_Human1.77986685
31JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69833483
32TP53_16413492_ChIP-PET_HCT116_Human1.69532957
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.61843605
34JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.61415160
35PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.60735002
36* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.58812113
37RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.55440097
38AR_21572438_ChIP-Seq_LNCaP_Human1.53679863
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52671756
40ZFP57_27257070_Chip-Seq_ESCs_Mouse1.51620895
41BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44924699
42SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.43326436
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.42929888
44TP53_20018659_ChIP-ChIP_R1E_Mouse1.42753128
45CSB_26484114_Chip-Seq_FIBROBLAST_Human1.42617990
46SMC1_22415368_ChIP-Seq_MEFs_Mouse1.40282252
47SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38538699
48STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.38121797
49SOX2_20726797_ChIP-Seq_SW620_Human1.37319566
50TP53_18474530_ChIP-ChIP_U2OS_Human1.35036117
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.34088208
52RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31881581
53FOXO3_23340844_ChIP-Seq_DLD1_Human1.31335979
54TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31284475
55SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30630783
56SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.30563233
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.29796547
58STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29579946
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29211822
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.28699217
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.28158458
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27899322
63HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.26529783
64MTF2_20144788_ChIP-Seq_MESCs_Mouse1.22346725
65POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.22160744
66TCF3_18692474_ChIP-Seq_MEFs_Mouse1.21772846
67TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.20319169
68AHR_22903824_ChIP-Seq_MCF-7_Human1.16949930
69NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.16229819
70SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.16169785
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.15913944
72AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15755239
73EZH2_18974828_ChIP-Seq_MESCs_Mouse1.13693527
74RNF2_18974828_ChIP-Seq_MESCs_Mouse1.13693527
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.12787690
76SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.12787690
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.11311589
78PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10253621
79CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.09998231
80ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.09535629
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.09121502
82SMAD4_21799915_ChIP-Seq_A2780_Human1.06849438
83RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.05185815
84ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05123751
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.05074506
86NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04606069
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.04582454
88NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.04542671
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.03057391
90EZH2_27294783_Chip-Seq_NPCs_Mouse1.02810182
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.02699456
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.01392538
93* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.00448499
94P63_26484246_Chip-Seq_KERATINOCYTES_Human1.00277747
95SA1_22415368_ChIP-Seq_MEFs_Mouse1.00141094
96MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.99445582
97PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99204483
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.98588569
99SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98280661
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.98026391
101SALL1_21062744_ChIP-ChIP_HESCs_Human0.97813893
102TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97734544
103EOMES_21245162_ChIP-Seq_HESCs_Human0.97238551
104TCF3_18692474_ChIP-Seq_MESCs_Mouse0.96624449
105SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96515321
106OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96378687
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.96332250
108ARNT_22903824_ChIP-Seq_MCF-7_Human0.96250007
109SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.96113696
110NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96045896
111PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.95109244
112SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.94540454
113TP53_23651856_ChIP-Seq_MEFs_Mouse0.94049856
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91338842
115EZH2_27304074_Chip-Seq_ESCs_Mouse0.90415202
116ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89858051
117* TP63_23658742_ChIP-Seq_EP156T_Human0.89561509
118TBX20_22080862_ChIP-Seq_HEART_Mouse0.89543483
119TBX20_22328084_ChIP-Seq_HEART_Mouse0.89543483
120ZNF217_24962896_ChIP-Seq_MCF-7_Human0.89276723
121WT1_25993318_ChIP-Seq_PODOCYTE_Human0.88065344
122TBX3_20139965_ChIP-Seq_ESCs_Mouse0.87969164
123RBPJ_22232070_ChIP-Seq_NCS_Mouse0.87484957
124CRX_20693478_ChIP-Seq_RETINA_Mouse0.87422355
125BCAT_22108803_ChIP-Seq_LS180_Human0.87284573
126NR3C1_21868756_ChIP-Seq_MCF10A_Human0.87046504
127TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86682299
128KDM2B_26808549_Chip-Seq_REH_Human0.86323088
129NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.86279123
130SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.86159267
131PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84924087
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.84755220
133TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83172939
134CDX2_20551321_ChIP-Seq_CACO-2_Human0.82896823
135P300_27058665_Chip-Seq_ZR-75-30cells_Human0.82888714
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.81960840

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology7.81073337
2MP0005275_abnormal_skin_tensile7.05413256
3MP0003705_abnormal_hypodermis_morpholog4.02660552
4MP0003279_aneurysm3.83256001
5MP0001958_emphysema3.68908382
6MP0010368_abnormal_lymphatic_system3.12045564
7MP0005508_abnormal_skeleton_morphology2.58011566
8MP0006054_spinal_hemorrhage2.51038081
9MP0002060_abnormal_skin_morphology2.44100724
10MP0002108_abnormal_muscle_morphology2.39358035
11MP0004272_abnormal_basement_membrane2.16951602
12MP0008438_abnormal_cutaneous_collagen10.0224798
13MP0001542_abnormal_bone_strength1.97739355
14MP0009384_cardiac_valve_regurgitation1.97671796
15MP0002295_abnormal_pulmonary_circulatio1.77551153
16MP0005257_abnormal_intraocular_pressure1.76243374
17MP0009780_abnormal_chondrocyte_physiolo1.75529929
18MP0003566_abnormal_cell_adhesion1.69126909
19MP0005023_abnormal_wound_healing1.68550347
20MP0001243_abnormal_dermal_layer1.65572805
21MP0010030_abnormal_orbit_morphology1.63644377
22MP0005171_absent_coat_pigmentation1.60487997
23MP0009250_abnormal_appendicular_skeleto1.52524513
24MP0005390_skeleton_phenotype1.51261053
25MP0003941_abnormal_skin_development1.46228754
26MP0004084_abnormal_cardiac_muscle1.44629075
27MP0003011_delayed_dark_adaptation1.35038479
28MP0001879_abnormal_lymphatic_vessel1.32318549
29MP0002933_joint_inflammation1.29443268
30MP0000749_muscle_degeneration1.25029070
31MP0004134_abnormal_chest_morphology1.22335518
32MP0002282_abnormal_trachea_morphology1.14062033
33MP0005623_abnormal_meninges_morphology1.11602243
34MP0003724_increased_susceptibility_to1.08666310
35MP0000343_altered_response_to1.05388708
36MP0002932_abnormal_joint_morphology1.05336430
37MP0000751_myopathy1.05030257
38MP0000750_abnormal_muscle_regeneration1.02292320
39MP0000163_abnormal_cartilage_morphology1.00160384
40MP0004858_abnormal_nervous_system0.99918956
41MP0005670_abnormal_white_adipose0.97978373
42MP0004036_abnormal_muscle_relaxation0.95280705
43MP0000767_abnormal_smooth_muscle0.94427219
44MP0002998_abnormal_bone_remodeling0.93134233
45MP0005164_abnormal_response_to0.91874346
46MP0003950_abnormal_plasma_membrane0.91514590
47MP0005388_respiratory_system_phenotype0.90331442
48MP0002133_abnormal_respiratory_system0.90331442
49MP0004233_abnormal_muscle_weight0.88772856
50MP0000534_abnormal_ureter_morphology0.87809322
51MP0005369_muscle_phenotype0.87182668
52MP0005595_abnormal_vascular_smooth0.86489875
53MP0004145_abnormal_muscle_electrophysio0.86147311
54MP0001533_abnormal_skeleton_physiology0.83411642
55MP0004883_abnormal_blood_vessel0.83037015
56MP0003385_abnormal_body_wall0.82763648
57MP0002249_abnormal_larynx_morphology0.81912933
58MP0002837_dystrophic_cardiac_calcinosis0.80906225
59MP0002269_muscular_atrophy0.80278702
60MP0003448_altered_tumor_morphology0.79631291
61MP0003091_abnormal_cell_migration0.79361499
62MP0002113_abnormal_skeleton_development0.77673109
63MP0000747_muscle_weakness0.77407143
64MP0003115_abnormal_respiratory_system0.77217595
65MP0001661_extended_life_span0.76936059
66MP0002168_other_aberrant_phenotype0.75610120
67MP0002896_abnormal_bone_mineralization0.75357762
68MP0005375_adipose_tissue_phenotype0.75209797
69MP0004130_abnormal_muscle_cell0.74946706
70MP0001175_abnormal_lung_morphology0.74797887
71MP0005330_cardiomyopathy0.74735247
72MP0002115_abnormal_skeleton_extremities0.74429110
73MP0003795_abnormal_bone_structure0.74142338
74MP0003045_fibrosis0.72434595
75MP0010352_gastrointestinal_tract_polyps0.69958379
76MP0000467_abnormal_esophagus_morphology0.69253473
77MP0002128_abnormal_blood_circulation0.69059970
78MP0002877_abnormal_melanocyte_morpholog0.67218204
79MP0000049_abnormal_middle_ear0.66175754
80MP0000538_abnormal_urinary_bladder0.64807032
81MP0003959_abnormal_lean_body0.64796015
82MP0003828_pulmonary_edema0.64488926
83MP0000230_abnormal_systemic_arterial0.64483797
84MP0000733_abnormal_muscle_development0.64159780
85MP0010771_integument_phenotype0.63585383
86MP0000759_abnormal_skeletal_muscle0.62805237
87MP0009053_abnormal_anal_canal0.62323608
88MP0001348_abnormal_lacrimal_gland0.61825217
89MP0001614_abnormal_blood_vessel0.60840587
90MP0002971_abnormal_brown_adipose0.60838702
91MP0000428_abnormal_craniofacial_morphol0.58439605
92MP0005165_increased_susceptibility_to0.57857006
93MP0008775_abnormal_heart_ventricle0.56918461
94MP0010386_abnormal_urinary_bladder0.56553525
95MP0000249_abnormal_blood_vessel0.55880820
96MP0003252_abnormal_bile_duct0.55147152
97MP0000432_abnormal_head_morphology0.55098605
98MP0002254_reproductive_system_inflammat0.54731108
99MP0000013_abnormal_adipose_tissue0.54274143
100MP0000569_abnormal_digit_pigmentation0.53162916
101MP0001299_abnormal_eye_distance/0.52827739
102MP0003283_abnormal_digestive_organ0.51635289
103MP0002972_abnormal_cardiac_muscle0.51527696
104MP0005620_abnormal_muscle_contractility0.51320588
105MP0008004_abnormal_stomach_pH0.50953976
106MP0002114_abnormal_axial_skeleton0.50925629
107MP0002925_abnormal_cardiovascular_devel0.50792363
108MP0006138_congestive_heart_failure0.50162609
109MP0004087_abnormal_muscle_fiber0.50112423
110MP0000003_abnormal_adipose_tissue0.49872357
111MP0005197_abnormal_uvea_morphology0.48788046
112MP0002116_abnormal_craniofacial_bone0.48450799
113MP0001177_atelectasis0.48041064
114MP0002233_abnormal_nose_morphology0.47628664
115MP0003942_abnormal_urinary_system0.47339787
116MP0005193_abnormal_anterior_eye0.46860867
117MP0001544_abnormal_cardiovascular_syste0.46464177
118MP0005385_cardiovascular_system_phenoty0.46464177
119MP0002106_abnormal_muscle_physiology0.46433163
120MP0003755_abnormal_palate_morphology0.44827472
121MP0002127_abnormal_cardiovascular_syste0.44785429
122MP0000762_abnormal_tongue_morphology0.44379020
123MP0000266_abnormal_heart_morphology0.44299818

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)8.28626590
2Broad metatarsal (HP:0001783)5.66425252
3Soft skin (HP:0000977)5.45690921
4Aortic dissection (HP:0002647)5.38058407
5Aortic aneurysm (HP:0004942)4.91545919
6Cerebral aneurysm (HP:0004944)4.43488410
7Dilatation of the ascending aorta (HP:0005111)4.39812209
8Bladder diverticulum (HP:0000015)4.31826055
9Vertebral compression fractures (HP:0002953)4.28851103
10Shallow orbits (HP:0000586)4.08172610
11Ankle contracture (HP:0006466)4.07262327
12Fragile skin (HP:0001030)4.04588467
13Atrophic scars (HP:0001075)4.03234919
14Increased connective tissue (HP:0009025)3.98427864
15Wormian bones (HP:0002645)3.90085710
16Biconcave vertebral bodies (HP:0004586)3.88995696
17Spondylolisthesis (HP:0003302)3.81522809
18Blue sclerae (HP:0000592)3.77556683
19Round ear (HP:0100830)3.60616833
20Cervical subluxation (HP:0003308)3.57052662
21Wrist flexion contracture (HP:0001239)3.48507796
22Abnormality of dentin (HP:0010299)3.47820355
23Mitral valve prolapse (HP:0001634)3.46911007
24Genu recurvatum (HP:0002816)3.46470990
25Peritonitis (HP:0002586)3.45352689
26Spinal rigidity (HP:0003306)3.34405433
27Abnormal delivery (HP:0001787)3.33526402
28Hyperextensible skin (HP:0000974)3.32683825
29Neonatal short-limb short stature (HP:0008921)3.25429504
30Vascular tortuosity (HP:0004948)3.24407463
31Overgrowth (HP:0001548)3.20807747
32Follicular hyperkeratosis (HP:0007502)3.15199407
33Osteolytic defects of the phalanges of the hand (HP:0009771)3.14471267
34Osteolytic defects of the hand bones (HP:0009699)3.14471267
35Mitral stenosis (HP:0001718)3.07186958
36Neoplasm of head and neck (HP:0012288)2.91211991
37Esophageal neoplasm (HP:0100751)2.91211991
38Type 1 muscle fiber predominance (HP:0003803)2.85656650
39Abnormality of the acetabulum (HP:0003170)2.81593806
40Joint stiffness (HP:0001387)2.81253770
41Mitral regurgitation (HP:0001653)2.80790199
42Popliteal pterygium (HP:0009756)2.75723788
43Ulnar deviation of the wrist (HP:0003049)2.75417564
44Alopecia of scalp (HP:0002293)2.74211577
45Striae distensae (HP:0001065)2.73518161
46Mildly elevated creatine phosphokinase (HP:0008180)2.71595469
47Nemaline bodies (HP:0003798)2.68815010
48Pulmonary artery stenosis (HP:0004415)2.65924694
49Aneurysm (HP:0002617)2.53701705
50Bowel diverticulosis (HP:0005222)2.53504695
51Ovoid vertebral bodies (HP:0003300)2.51146510
52Thin bony cortex (HP:0002753)2.49416992
53Wide anterior fontanel (HP:0000260)2.47237116
54Aortic valve stenosis (HP:0001650)2.45923526
55Subacute progressive viral hepatitis (HP:0006572)2.44378661
56Mesomelia (HP:0003027)2.41827898
57Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.40609710
58Arterial tortuosity (HP:0005116)2.36231975
59Joint laxity (HP:0001388)2.33396329
60Breech presentation (HP:0001623)2.32026643
61Fused cervical vertebrae (HP:0002949)2.31321186
62Increased variability in muscle fiber diameter (HP:0003557)2.31060976
63Camptodactyly of toe (HP:0001836)2.29776892
64Beaking of vertebral bodies (HP:0004568)2.27547753
65Distal lower limb muscle weakness (HP:0009053)2.25784359
66Limited hip movement (HP:0008800)2.23992981
67Decreased subcutaneous fat (HP:0001002)2.23418498
68Muscle fiber inclusion bodies (HP:0100299)2.23072020
69Delayed cranial suture closure (HP:0000270)2.17004229
70Cardiovascular calcification (HP:0011915)2.13785892
71Osteoarthritis (HP:0002758)2.12633151
72Generalized amyotrophy (HP:0003700)2.10398503
73Delayed closure of the anterior fontanelle (HP:0001476)2.10380016
74Deformed tarsal bones (HP:0008119)2.09752515
75Broad ribs (HP:0000885)2.08564725
76Distal arthrogryposis (HP:0005684)2.07895239
77Short nail (HP:0001799)2.07880558
78Hip contracture (HP:0003273)2.05886303
79Inguinal hernia (HP:0000023)2.04226682
80Calcaneovalgus deformity (HP:0001848)2.04117336
81Delayed gross motor development (HP:0002194)2.04042490
82Abnormality of skeletal muscle fiber size (HP:0012084)2.02235484
83Hyporeflexia of lower limbs (HP:0002600)2.01255309
84Flat cornea (HP:0007720)2.00072449
85Protrusio acetabuli (HP:0003179)10.0703901
86Slender build (HP:0001533)1.99991660
87Aortic regurgitation (HP:0001659)1.98621399
88Redundant skin (HP:0001582)1.98366895
89Pterygium (HP:0001059)1.97619207
90Elbow flexion contracture (HP:0002987)1.96891116
91Ectopia lentis (HP:0001083)1.95711882
92Abnormal cartilage morphology (HP:0002763)1.95658331
93Coronal craniosynostosis (HP:0004440)1.93888731
94Knee flexion contracture (HP:0006380)1.93483380
95Bell-shaped thorax (HP:0001591)1.93303338
96Right ventricular cardiomyopathy (HP:0011663)1.93302416
97Mild short stature (HP:0003502)1.92647501
98Keratoconus (HP:0000563)1.91501286
99Coxa vara (HP:0002812)1.89928856
100Disproportionate tall stature (HP:0001519)1.89431202
101Gowers sign (HP:0003391)1.89206992
102Trismus (HP:0000211)1.88038100
103Fatigable weakness (HP:0003473)1.86431330
104Abnormality of the neuromuscular junction (HP:0003398)1.86431330
105Malignant hyperthermia (HP:0002047)1.86227396
106Venous abnormality (HP:0002624)1.85013251
107Patent foramen ovale (HP:0001655)1.84811487
108Corneal dystrophy (HP:0001131)1.83524132
109Abnormality of the distal phalanges of the toes (HP:0010182)1.80668393
110Lipoatrophy (HP:0100578)1.80173624
111Emphysema (HP:0002097)1.80118520
112Hypoplastic ischia (HP:0003175)1.79716425
113Neck muscle weakness (HP:0000467)1.79175359
114Short hallux (HP:0010109)1.79143893
115Abnormality of placental membranes (HP:0011409)1.78851091
116Amniotic constriction ring (HP:0009775)1.78851091
117Absent frontal sinuses (HP:0002688)1.76474107
118Hypoplasia of the iris (HP:0007676)1.74802204
119Decreased skull ossification (HP:0004331)1.74375504
120Narrow nasal bridge (HP:0000446)1.74227167
121Platyspondyly (HP:0000926)1.72457298
122Venous insufficiency (HP:0005293)1.70414866
123Osteopenia (HP:0000938)1.68743092
124Flexion contracture of toe (HP:0005830)1.67735094
125Joint contractures involving the joints of the feet (HP:0100492)1.67735094
126Thin skin (HP:0000963)1.67540822
127Persistence of primary teeth (HP:0006335)1.64332573
128Infantile muscular hypotonia (HP:0008947)1.64191467
129Tracheal stenosis (HP:0002777)1.63211158
130Increased corneal curvature (HP:0100692)1.63126418

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.17344970
2TGFBR24.12259694
3MUSK3.73205960
4DDR23.34786513
5ERBB33.18581420
6PDGFRA2.88907137
7PIM22.88643763
8LATS22.75099183
9CDK122.53405419
10GRK52.36836446
11STK38L2.30919690
12EPHB22.26203441
13EPHA32.08317180
14MOS1.83433637
15PAK41.79804152
16STK241.78741571
17TTN1.78366814
18FER1.73699915
19TRPM71.72680584
20PDK21.61249885
21ZAK1.57175163
22PLK21.52864893
23NEK91.52010833
24NME21.48742731
25MAP3K121.46399940
26TRIB31.45327966
27PRPF4B1.44542113
28STK31.33345195
29MYLK1.28521791
30MAPKAPK31.27518122
31PAK31.27295461
32LIMK11.20153699
33STK381.19208289
34BMX1.18836015
35ADRBK21.16354710
36PTK2B1.14763266
37WNK11.14102323
38MAPK71.08440609
39TESK11.07095016
40MAP3K31.04224627
41BMPR21.03176290
42PAK21.02446931
43RIPK11.01932070
44TIE11.01903105
45PRKD21.00957652
46LATS10.95807919
47PRKCH0.94342249
48RPS6KA40.90083807
49NTRK10.85262754
50ROCK10.84827285
51ADRBK10.84371180
52FLT30.81035437
53PDGFRB0.80166150
54MAPKAPK50.78501545
55PTK20.78213955
56STK100.76671627
57PIK3CA0.75005884
58GRK10.74714137
59CDC42BPA0.73366689
60GRK70.73018905
61MAP3K60.72854743
62CSF1R0.72264744
63MAP2K10.71976404
64DMPK0.71178291
65EIF2AK20.70374542
66AKT30.67441711
67TYRO30.66509546
68PIK3CG0.65278626
69ABL20.64962547
70JAK10.64288719
71RPS6KA20.63344986
72CAMK2G0.63069192
73ILK0.61844137
74BCKDK0.60470198
75CAMK10.60156420
76PRKD30.59510036
77HIPK20.59258529
78DAPK30.59041655
79SIK10.58242108
80FRK0.57115402
81ABL10.56538849
82MST1R0.56503308
83FGFR30.55530304
84IGF1R0.54939476
85NLK0.54649204
86CAMK40.54343392
87INSR0.54110306
88PRKD10.54002785
89MELK0.53674226
90TGFBR10.53633866
91ARAF0.52772649
92BRAF0.51833180
93ERBB40.51509734
94TYK20.51131714
95MAP3K70.50093407
96EPHB10.49875279
97CAMK2D0.49545305
98PBK0.49207108
99KIT0.49076933
100PDK30.48307163
101PDK40.48307163
102ROCK20.48147703
103PKN10.47214452
104MET0.46637221
105PAK10.46607138
106PRKG10.46375248
107IRAK30.46240398
108MAPK120.46161617
109GSK3A0.45442011
110MTOR0.44472553
111PRKG20.43858771
112IKBKB0.42915960
113MAPK40.42580933
114PNCK0.41748110
115MAP2K20.41736889
116TTK0.39312603
117OBSCN0.38657106
118MAPK10.38563845
119PINK10.37601366
120PRKCE0.36564224
121ERBB20.35717117
122CAMK2B0.35227626
123CSK0.35220388
124CDK60.34990320
125MARK10.32513003
126MARK20.32372253
127PRKAA20.30866488
128JAK30.28963732
129PAK60.27715321
130CAMK2A0.20670712
131SRC0.20583747

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045123.81504686
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.55111977
3Malaria_Homo sapiens_hsa051443.02631987
4Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005202.97401542
5Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.95306377
6Protein digestion and absorption_Homo sapiens_hsa049742.78266393
7Arachidonic acid metabolism_Homo sapiens_hsa005902.64386815
8Galactose metabolism_Homo sapiens_hsa000522.58639569
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.56021244
10Amoebiasis_Homo sapiens_hsa051462.48563264
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.42829175
12Dilated cardiomyopathy_Homo sapiens_hsa054142.33791493
13Focal adhesion_Homo sapiens_hsa045102.30284969
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.30070158
15TGF-beta signaling pathway_Homo sapiens_hsa043502.11875640
16Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.03405320
17Proteoglycans in cancer_Homo sapiens_hsa052051.87543791
18Starch and sucrose metabolism_Homo sapiens_hsa005001.75325195
19Glycosaminoglycan degradation_Homo sapiens_hsa005311.70366746
20TNF signaling pathway_Homo sapiens_hsa046681.50499473
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.49114587
22Pentose and glucuronate interconversions_Homo sapiens_hsa000401.43943942
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.43416673
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.41769105
25Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.34999618
26Rheumatoid arthritis_Homo sapiens_hsa053231.29583454
27Bladder cancer_Homo sapiens_hsa052191.29580516
28Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.22462003
29Complement and coagulation cascades_Homo sapiens_hsa046101.21272133
30Viral myocarditis_Homo sapiens_hsa054161.14981114
31Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12491649
32Small cell lung cancer_Homo sapiens_hsa052221.11633189
33Fructose and mannose metabolism_Homo sapiens_hsa000511.10788674
34Hedgehog signaling pathway_Homo sapiens_hsa043401.10217096
35PPAR signaling pathway_Homo sapiens_hsa033201.09911528
36Adherens junction_Homo sapiens_hsa045201.09692115
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.07509867
38Sulfur metabolism_Homo sapiens_hsa009201.07305948
39Legionellosis_Homo sapiens_hsa051341.05894428
40Melanoma_Homo sapiens_hsa052181.04894968
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03093818
42Hippo signaling pathway_Homo sapiens_hsa043901.02243376
43Pathways in cancer_Homo sapiens_hsa052001.00096337
44Chronic myeloid leukemia_Homo sapiens_hsa052200.97028300
45Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95543605
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.94567487
47MicroRNAs in cancer_Homo sapiens_hsa052060.93279212
48Basal cell carcinoma_Homo sapiens_hsa052170.93252007
49Axon guidance_Homo sapiens_hsa043600.92292337
50Renin secretion_Homo sapiens_hsa049240.91919540
51Toxoplasmosis_Homo sapiens_hsa051450.89215927
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.88489382
53Glutathione metabolism_Homo sapiens_hsa004800.86243534
54Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.86114707
55Thyroid cancer_Homo sapiens_hsa052160.85448882
56Leishmaniasis_Homo sapiens_hsa051400.85216901
57Ovarian steroidogenesis_Homo sapiens_hsa049130.85092664
58Circadian rhythm_Homo sapiens_hsa047100.82161134
59Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.81949788
60Apoptosis_Homo sapiens_hsa042100.81488523
61Pancreatic cancer_Homo sapiens_hsa052120.80940304
62AMPK signaling pathway_Homo sapiens_hsa041520.80810208
63Gap junction_Homo sapiens_hsa045400.74349435
64NOD-like receptor signaling pathway_Homo sapiens_hsa046210.73853194
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.73589921
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.72532884
67Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71540001
68Rap1 signaling pathway_Homo sapiens_hsa040150.70303893
69Prostate cancer_Homo sapiens_hsa052150.70226799
70Salmonella infection_Homo sapiens_hsa051320.69930370
71HIF-1 signaling pathway_Homo sapiens_hsa040660.69336511
72Renin-angiotensin system_Homo sapiens_hsa046140.68001919
73Platelet activation_Homo sapiens_hsa046110.66129495
74Pertussis_Homo sapiens_hsa051330.65999111
75Other glycan degradation_Homo sapiens_hsa005110.64639795
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.64569846
77Ras signaling pathway_Homo sapiens_hsa040140.63943293
78Vitamin B6 metabolism_Homo sapiens_hsa007500.63445157
79p53 signaling pathway_Homo sapiens_hsa041150.63430158
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62903394
81Wnt signaling pathway_Homo sapiens_hsa043100.62739626
82Oxytocin signaling pathway_Homo sapiens_hsa049210.62396269
83Acute myeloid leukemia_Homo sapiens_hsa052210.61813596
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60920366
85African trypanosomiasis_Homo sapiens_hsa051430.60634842
86Thyroid hormone synthesis_Homo sapiens_hsa049180.60163239
87Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60161967
88Calcium signaling pathway_Homo sapiens_hsa040200.58310232
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57525809
90Phagosome_Homo sapiens_hsa041450.55596548
91Vascular smooth muscle contraction_Homo sapiens_hsa042700.55432141
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54923260
93Prion diseases_Homo sapiens_hsa050200.54902514
94Chemical carcinogenesis_Homo sapiens_hsa052040.53364495
95Glycerolipid metabolism_Homo sapiens_hsa005610.53044798
96Cardiac muscle contraction_Homo sapiens_hsa042600.52861916
97HTLV-I infection_Homo sapiens_hsa051660.51082891
98Mineral absorption_Homo sapiens_hsa049780.50885671
99Dorso-ventral axis formation_Homo sapiens_hsa043200.50473230
100Adipocytokine signaling pathway_Homo sapiens_hsa049200.48872749
101ABC transporters_Homo sapiens_hsa020100.48274678
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.47842664
103Linoleic acid metabolism_Homo sapiens_hsa005910.47229505
104Fatty acid degradation_Homo sapiens_hsa000710.47016959
105Hepatitis B_Homo sapiens_hsa051610.46260842
106Tryptophan metabolism_Homo sapiens_hsa003800.43896418
107Lysosome_Homo sapiens_hsa041420.43249145
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43040946
109Glucagon signaling pathway_Homo sapiens_hsa049220.42077077
110Selenocompound metabolism_Homo sapiens_hsa004500.41936134
111SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41581094
112Insulin resistance_Homo sapiens_hsa049310.41117291
113NF-kappa B signaling pathway_Homo sapiens_hsa040640.41059594
114alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.40881678
115Glioma_Homo sapiens_hsa052140.40349977
116FoxO signaling pathway_Homo sapiens_hsa040680.38781544
117Endocytosis_Homo sapiens_hsa041440.38762411
118N-Glycan biosynthesis_Homo sapiens_hsa005100.38729127
119Colorectal cancer_Homo sapiens_hsa052100.37813439
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36989980
121Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.36599857
122Histidine metabolism_Homo sapiens_hsa003400.33092855
123Tight junction_Homo sapiens_hsa045300.32736520
124cAMP signaling pathway_Homo sapiens_hsa040240.32685485
125Sphingolipid metabolism_Homo sapiens_hsa006000.31738447
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31696002
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.31623465
128Tyrosine metabolism_Homo sapiens_hsa003500.31031865
129mTOR signaling pathway_Homo sapiens_hsa041500.30046457
130Arginine and proline metabolism_Homo sapiens_hsa003300.30031937
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28597753
132Melanogenesis_Homo sapiens_hsa049160.27795280
133Shigellosis_Homo sapiens_hsa051310.26274798
134Retinol metabolism_Homo sapiens_hsa008300.25849287
135GnRH signaling pathway_Homo sapiens_hsa049120.25798977
136Insulin signaling pathway_Homo sapiens_hsa049100.25649503
137MAPK signaling pathway_Homo sapiens_hsa040100.23385948
138Lysine degradation_Homo sapiens_hsa003100.23349654
139Salivary secretion_Homo sapiens_hsa049700.22609397
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.21611082

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