MFGE8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1aminoglycoside antibiotic metabolic process (GO:0030647)6.65388912
2regulation of response to osmotic stress (GO:0047484)6.03365099
3protein heterotrimerization (GO:0070208)5.57454687
4negative regulation of telomerase activity (GO:0051974)5.50432285
5notochord development (GO:0030903)5.24828420
6planar cell polarity pathway involved in neural tube closure (GO:0090179)5.19897313
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.92414845
8maintenance of protein location in nucleus (GO:0051457)4.90871949
9collagen fibril organization (GO:0030199)4.84388230
10negative regulation of epidermis development (GO:0045683)4.80208480
11paraxial mesoderm development (GO:0048339)4.80204646
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.77226595
13endodermal cell differentiation (GO:0035987)4.71590523
14response to dietary excess (GO:0002021)4.69121369
15somite rostral/caudal axis specification (GO:0032525)4.67379141
16hormone catabolic process (GO:0042447)4.54537655
17vitamin A metabolic process (GO:0006776)4.45810330
18cellular response to cholesterol (GO:0071397)4.32801211
19skin morphogenesis (GO:0043589)4.32108587
20nucleoside transmembrane transport (GO:1901642)4.27075977
21basement membrane organization (GO:0071711)4.23393984
22positive regulation of histone deacetylation (GO:0031065)4.22852064
23cellular modified amino acid catabolic process (GO:0042219)4.21638598
24regulation of apoptotic process involved in morphogenesis (GO:1902337)4.17276935
25negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.13167548
26regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.07944720
27phenol-containing compound catabolic process (GO:0019336)4.07533907
28muscle organ morphogenesis (GO:0048644)4.07377083
29nucleoside transport (GO:0015858)4.07282018
30endothelial cell morphogenesis (GO:0001886)4.00311679
31adherens junction assembly (GO:0034333)3.98795978
32positive regulation of protein deacetylation (GO:0090312)3.97366400
33convergent extension (GO:0060026)3.96243026
34negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.96162153
35branching involved in mammary gland duct morphogenesis (GO:0060444)3.92225886
36extracellular matrix assembly (GO:0085029)3.92197772
37L-serine transport (GO:0015825)3.90359566
38protein retention in ER lumen (GO:0006621)3.88315858
39chondroitin sulfate catabolic process (GO:0030207)3.87999368
40cell migration involved in heart development (GO:0060973)3.86903011
41proline transport (GO:0015824)3.86657125
42histone H4-K8 acetylation (GO:0043982)3.86106160
43histone H4-K5 acetylation (GO:0043981)3.86106160
44establishment of apical/basal cell polarity (GO:0035089)3.84426468
45ovulation cycle (GO:0042698)3.84368486
46chondrocyte proliferation (GO:0035988)3.83885427
47cell-substrate adherens junction assembly (GO:0007045)3.80371597
48focal adhesion assembly (GO:0048041)3.80371597
49cell-substrate junction assembly (GO:0007044)3.78700151
50negative regulation of smoothened signaling pathway (GO:0045879)3.72316580
51collagen metabolic process (GO:0032963)3.71818230
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.71390879
53regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.69787196
54alanine transport (GO:0032328)3.68054852
55type B pancreatic cell proliferation (GO:0044342)3.66561210
56Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.63605842
57regulation of telomere maintenance via telomerase (GO:0032210)3.61283021
58kidney mesenchyme development (GO:0072074)3.60170591
59negative regulation of cell cycle G2/M phase transition (GO:1902750)3.57814254
60negative regulation of chondrocyte differentiation (GO:0032331)3.57463475
61positive regulation of macrophage cytokine production (GO:0060907)3.52723150
62collagen catabolic process (GO:0030574)3.52284172
63tooth mineralization (GO:0034505)3.48311723
64extracellular fibril organization (GO:0043206)3.46606747
65regulation of establishment of planar polarity (GO:0090175)3.44427643
66multicellular organismal macromolecule metabolic process (GO:0044259)3.43888981
67regulation of MHC class I biosynthetic process (GO:0045343)3.42492317
68epithelial cell-cell adhesion (GO:0090136)3.42443816
69virion attachment to host cell (GO:0019062)3.41630890
70adhesion of symbiont to host cell (GO:0044650)3.41630890
71heart trabecula morphogenesis (GO:0061384)3.40200506
72cellular response to sterol (GO:0036315)3.39612074
73serine transport (GO:0032329)3.39518036
74regulation of hippo signaling (GO:0035330)3.35796737
75apoptotic cell clearance (GO:0043277)3.34289653
76negative regulation of epidermal cell differentiation (GO:0045605)3.33790574
77trabecula morphogenesis (GO:0061383)3.30919396
78protein localization to kinetochore (GO:0034501)3.30201660
79epoxygenase P450 pathway (GO:0019373)3.28759613
80bone trabecula formation (GO:0060346)3.25854063
81positive regulation of endothelial cell apoptotic process (GO:2000353)3.24369249
82positive regulation of SMAD protein import into nucleus (GO:0060391)3.23195934
83cellular response to vitamin (GO:0071295)3.23008802
84multicellular organismal metabolic process (GO:0044236)3.22614069
85biotin metabolic process (GO:0006768)3.21742092
86extracellular matrix disassembly (GO:0022617)3.21543676
87multicellular organismal catabolic process (GO:0044243)3.21148172
88sequestering of extracellular ligand from receptor (GO:0035581)3.21118647
89metanephric mesenchyme development (GO:0072075)3.19372429
90keratan sulfate catabolic process (GO:0042340)3.16952518
91stress fiber assembly (GO:0043149)3.16244429
92negative regulation of smooth muscle cell migration (GO:0014912)3.15385339
93cell migration involved in sprouting angiogenesis (GO:0002042)3.14847576
94blood vessel maturation (GO:0001955)3.12683722
95rRNA transcription (GO:0009303)3.12613742
96positive regulation of triglyceride biosynthetic process (GO:0010867)3.11891149
97non-canonical Wnt signaling pathway (GO:0035567)3.10985161
98barbed-end actin filament capping (GO:0051016)3.10756161
99epithelial cell differentiation involved in prostate gland development (GO:0060742)3.10493877
100maintenance of protein localization in organelle (GO:0072595)3.10475652
101regulation of cell fate specification (GO:0042659)3.08776950
102negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.08494366
103glomerular visceral epithelial cell development (GO:0072015)3.08098986
104cardiac myofibril assembly (GO:0055003)3.07840488
105cochlea morphogenesis (GO:0090103)3.07515178
106regulation of telomerase activity (GO:0051972)3.07374756
107adhesion of symbiont to host (GO:0044406)3.07205849
108regulation of nuclear cell cycle DNA replication (GO:0033262)3.06571787
109glial cell proliferation (GO:0014009)3.06354369
110mesenchymal-epithelial cell signaling (GO:0060638)3.05735657
111vascular endothelial growth factor signaling pathway (GO:0038084)3.05399449
112cytidine catabolic process (GO:0006216)3.04521131
113cytidine deamination (GO:0009972)3.04521131
114cytidine metabolic process (GO:0046087)3.04521131
115establishment or maintenance of monopolar cell polarity (GO:0061339)3.04514708
116establishment of monopolar cell polarity (GO:0061162)3.04514708
117endocardial cushion development (GO:0003197)3.03647906
118cell proliferation involved in metanephros development (GO:0072203)3.02607077
119substrate adhesion-dependent cell spreading (GO:0034446)2.99323354
120regulation of cilium movement (GO:0003352)2.98397480
121hemidesmosome assembly (GO:0031581)2.97963559
122regulation of glucose import in response to insulin stimulus (GO:2001273)2.97584649
123histone H4-K12 acetylation (GO:0043983)2.97235565
124negative regulation of osteoblast proliferation (GO:0033689)2.96561608
125Golgi transport vesicle coating (GO:0048200)2.95100656
126COPI coating of Golgi vesicle (GO:0048205)2.95100656
127negative regulation of potassium ion transmembrane transport (GO:1901380)2.94618239
128fibril organization (GO:0097435)2.94032003
129atrioventricular valve morphogenesis (GO:0003181)2.92732833
130G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.92150252
131heterochromatin organization (GO:0070828)2.91094500
132sulfur amino acid catabolic process (GO:0000098)2.90992679
133positive regulation of osteoblast proliferation (GO:0033690)2.89470027
134dermatan sulfate biosynthetic process (GO:0030208)2.89395958
135establishment of endothelial barrier (GO:0061028)2.88975911
136negative regulation of astrocyte differentiation (GO:0048712)2.88236189
137polarized epithelial cell differentiation (GO:0030859)2.87820621
138positive regulation of tissue remodeling (GO:0034105)2.86771672
139regulation of gene silencing by RNA (GO:0060966)2.85987250
140regulation of posttranscriptional gene silencing (GO:0060147)2.85987250
141regulation of gene silencing by miRNA (GO:0060964)2.85987250
142quinone metabolic process (GO:1901661)2.85857791
143positive regulation of cellular amide metabolic process (GO:0034250)2.85153505
144primitive streak formation (GO:0090009)2.84519721
145muscle cell migration (GO:0014812)2.84166178
146negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.83833347
147cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.83161312
148mammary gland development (GO:0030879)2.83158970
149heparan sulfate proteoglycan biosynthetic process (GO:0015012)2.81472262
150branching involved in salivary gland morphogenesis (GO:0060445)2.81415760
151regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.80833716
152regulation of macrophage cytokine production (GO:0010935)2.79561745
153hypotonic response (GO:0006971)2.79202446
154trabecula formation (GO:0060343)2.78916723
155negative regulation of DNA biosynthetic process (GO:2000279)2.78489002
156extracellular matrix organization (GO:0030198)2.78377749
157extracellular structure organization (GO:0043062)2.77198743
158dermatan sulfate metabolic process (GO:0030205)2.76017712
159cardiovascular system development (GO:0072358)2.75931281
160regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.75238472
161outer ear morphogenesis (GO:0042473)2.74971547
162coenzyme catabolic process (GO:0009109)2.74506033
163intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.74450034
164positive regulation of DNA-dependent DNA replication (GO:2000105)2.73332938
165cell adhesion mediated by integrin (GO:0033627)2.73232686
166transepithelial transport (GO:0070633)2.72701132
167regulation of osteoblast proliferation (GO:0033688)2.69918069
168maternal placenta development (GO:0001893)2.69762916
169semaphorin-plexin signaling pathway (GO:0071526)2.69455426
170intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)2.67399878
171vagina development (GO:0060068)2.66992567
172negative regulation of cartilage development (GO:0061037)2.65150421
173modified amino acid transport (GO:0072337)2.64000390
174positive regulation of blood vessel endothelial cell migration (GO:0043536)2.63843215
175negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.63305544
176neuron projection extension involved in neuron projection guidance (GO:1902284)2.62995499
177axon extension involved in axon guidance (GO:0048846)2.62995499
178regulation of tight junction assembly (GO:2000810)2.62982647
179regulation of phospholipid biosynthetic process (GO:0071071)2.61571006
180cellular response to vitamin D (GO:0071305)2.61351560
181retinoic acid receptor signaling pathway (GO:0048384)2.61023196
182hippo signaling (GO:0035329)2.60978288
183histone H4-K16 acetylation (GO:0043984)2.60702097
184C4-dicarboxylate transport (GO:0015740)2.60358915
185regulation of SMAD protein import into nucleus (GO:0060390)2.60276147
186glomerular basement membrane development (GO:0032836)2.60233833
187glomerular epithelial cell development (GO:0072310)2.59824873
188positive regulation of catenin import into nucleus (GO:0035413)2.59197999
189positive regulation of odontogenesis (GO:0042482)2.58699094
190response to cholesterol (GO:0070723)2.58548880
191regulation of catenin import into nucleus (GO:0035412)2.56623125
192polyketide metabolic process (GO:0030638)10.4480235
193doxorubicin metabolic process (GO:0044598)10.4480235
194daunorubicin metabolic process (GO:0044597)10.4480235

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.75712710
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.31007711
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.31007711
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.31007711
5POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.23019968
6SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.09858139
7HIF1A_21447827_ChIP-Seq_MCF-7_Human2.96752938
8NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.96270365
9SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.94241674
10TCF3_18692474_ChIP-Seq_MEFs_Mouse2.75235697
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.71378381
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.71082484
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.58110434
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56392478
15TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.43483557
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.34573797
17ESR2_21235772_ChIP-Seq_MCF-7_Human2.25100015
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.17276538
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16616429
20ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.11213276
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.02226156
22TP63_19390658_ChIP-ChIP_HaCaT_Human1.96006111
23NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.94089347
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89528175
25WT1_19549856_ChIP-ChIP_CCG9911_Human1.86454063
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86318457
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77823778
28UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.76166806
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75908546
30ESR1_15608294_ChIP-ChIP_MCF-7_Human1.74311495
31* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.71616499
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.70959581
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.69262053
34POU5F1_16518401_ChIP-PET_MESCs_Mouse1.68332557
35KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.68103958
36NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.65490633
37* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60365339
38NANOG_18692474_ChIP-Seq_MEFs_Mouse1.59385312
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55835444
40ZFP281_27345836_Chip-Seq_ESCs_Mouse1.54991903
41* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.52919788
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.50438423
43SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.49185842
44RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45430769
45CDX2_20551321_ChIP-Seq_CACO-2_Human1.45258299
46NFIB_24661679_ChIP-Seq_LUNG_Mouse1.45160432
47KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44715660
48NANOG_18692474_ChIP-Seq_MESCs_Mouse1.42275140
49ZNF263_19887448_ChIP-Seq_K562_Human1.40917129
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.40762619
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.40762619
52RACK7_27058665_Chip-Seq_MCF-7_Human1.39938672
53* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.39390507
54WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.39215975
55SMC3_22415368_ChIP-Seq_MEFs_Mouse1.38472910
56ESR1_21235772_ChIP-Seq_MCF-7_Human1.37006700
57BRD4_25478319_ChIP-Seq_HGPS_Human1.35948256
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.34737849
59IKZF1_21737484_ChIP-ChIP_HCT116_Human1.33779598
60PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.32534535
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32319897
62SMC1_22415368_ChIP-Seq_MEFs_Mouse1.31775321
63* TP53_23651856_ChIP-Seq_MEFs_Mouse1.31497029
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.31440916
65* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.31289969
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.30630785
67DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27527355
68TET1_21490601_ChIP-Seq_MESCs_Mouse1.26363860
69CLOCK_20551151_ChIP-Seq_293T_Human1.26138912
70LXR_22292898_ChIP-Seq_THP-1_Human1.26053625
71RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25601292
72EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25601292
73KDM2B_26808549_Chip-Seq_DND41_Human1.24536174
74ISL1_27105846_Chip-Seq_CPCs_Mouse1.24249974
75STAT6_21828071_ChIP-Seq_BEAS2B_Human1.24095504
76EED_16625203_ChIP-ChIP_MESCs_Mouse1.23971829
77OCT4_18692474_ChIP-Seq_MEFs_Mouse1.23833769
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23313570
79SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.22882177
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.22379556
81UBF1/2_26484160_Chip-Seq_HMECs_Human1.21731017
82KDM2B_26808549_Chip-Seq_K562_Human1.20466104
83SOX2_18692474_ChIP-Seq_MEFs_Mouse1.19154011
84* ATF3_27146783_Chip-Seq_COLON_Human1.16055596
85SA1_22415368_ChIP-Seq_MEFs_Mouse1.14328995
86TP53_22127205_ChIP-Seq_IMR90_Human1.14023339
87* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13723895
88TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12101160
89EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10934290
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10554053
91NANOG_16518401_ChIP-PET_MESCs_Mouse1.10488378
92CTCF_27219007_Chip-Seq_Bcells_Human1.08686776
93SOX2_18555785_ChIP-Seq_MESCs_Mouse1.07154394
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06207012
95ERG_21242973_ChIP-ChIP_JURKAT_Human1.06072563
96E2F1_17053090_ChIP-ChIP_MCF-7_Human1.05362255
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.05199140
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.04791181
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04178275
100SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04165704
101SMC4_20622854_ChIP-Seq_HELA_Human1.04033384
102NANOG_16153702_ChIP-ChIP_HESCs_Human1.03821630
103POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.03639101
104TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03413433
105POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.03346243
106MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03207027
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02824526
108NCOR1_26117541_ChIP-Seq_K562_Human1.02726481
109SA1_27219007_Chip-Seq_ERYTHROID_Human1.01710581
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00487848
111PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99096449
112KDM2B_26808549_Chip-Seq_JURKAT_Human0.98343068
113OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.98143277
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97036366
115NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96574813
116TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.96533003
117TBX3_20139965_ChIP-Seq_ESCs_Mouse0.96492237
118POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.95916149
119* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95092119
120P300_27058665_Chip-Seq_ZR-75-30cells_Human0.95091009
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.94817925
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.94171434
123EGR1_19374776_ChIP-ChIP_THP-1_Human0.94119185
124NANOG_21062744_ChIP-ChIP_HESCs_Human0.94091525
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93973396
126* CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93433975
127HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93221252
128CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.93035606
129SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.92600574
130EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.91562878
131* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90252633
132* KLF5_25053715_ChIP-Seq_YYC3_Human0.90131614
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.88554718
134TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.88474830
135ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.88219144
136* P63_26484246_Chip-Seq_KERATINOCYTES_Human0.86710408
137TP63_22573176_ChIP-Seq_HFKS_Human0.84569878
138* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.83060460
139TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.81979403
140EOMES_21245162_ChIP-Seq_HESCs_Human0.80536033
141CSB_26484114_Chip-Seq_FIBROBLAST_Human0.80308972
142RUNX1_27514584_Chip-Seq_MCF-7_Human0.77387915
143IRF1_19129219_ChIP-ChIP_H3396_Human0.76257182
144PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.75614976
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.75290828
146ELF1_20517297_ChIP-Seq_JURKAT_Human0.75266027
147* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74156075
148* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73795522
149KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.73537626

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation5.84931003
2MP0004858_abnormal_nervous_system4.37697370
3MP0003705_abnormal_hypodermis_morpholog4.18232164
4MP0005503_abnormal_tendon_morphology4.07366008
5MP0004264_abnormal_extraembryonic_tissu3.28934528
6MP0000751_myopathy2.97169273
7MP0003279_aneurysm2.73104778
8MP0005257_abnormal_intraocular_pressure2.68055298
9MP0003941_abnormal_skin_development2.49883658
10MP0006292_abnormal_olfactory_placode2.42355278
11MP0002332_abnormal_exercise_endurance2.37360014
12MP0010030_abnormal_orbit_morphology2.31118440
13MP0004272_abnormal_basement_membrane2.16767133
14MP0008438_abnormal_cutaneous_collagen2.12204877
15MP0002653_abnormal_ependyma_morphology2.04858726
16MP0000750_abnormal_muscle_regeneration2.04787630
17MP0002127_abnormal_cardiovascular_syste1.94642051
18MP0010352_gastrointestinal_tract_polyps1.94227697
19MP0006054_spinal_hemorrhage1.88624913
20MP0003890_abnormal_embryonic-extraembry1.82474661
21MP0010368_abnormal_lymphatic_system1.82132341
22MP0002060_abnormal_skin_morphology1.78027554
23MP0001542_abnormal_bone_strength1.77822056
24MP0001849_ear_inflammation1.76065010
25MP0001299_abnormal_eye_distance/1.73721322
26MP0005499_abnormal_olfactory_system1.73410836
27MP0005394_taste/olfaction_phenotype1.73410836
28MP0003183_abnormal_peptide_metabolism1.72748014
29MP0009384_cardiac_valve_regurgitation1.70737674
30MP0005508_abnormal_skeleton_morphology1.68542751
31MP0000049_abnormal_middle_ear1.63103176
32MP0005171_absent_coat_pigmentation1.57883423
33MP0005075_abnormal_melanosome_morpholog1.53544919
34MP0003122_maternal_imprinting1.51516826
35MP0000428_abnormal_craniofacial_morphol1.46287530
36MP0005623_abnormal_meninges_morphology1.45453938
37MP0000013_abnormal_adipose_tissue1.44536209
38MP0000762_abnormal_tongue_morphology1.38159480
39MP0000343_altered_response_to1.35573112
40MP0003136_yellow_coat_color1.32989008
41MP0003091_abnormal_cell_migration1.31995749
42MP0005248_abnormal_Harderian_gland1.29676629
43MP0001853_heart_inflammation1.28676224
44* MP0001881_abnormal_mammary_gland1.26270711
45MP0003137_abnormal_impulse_conducting1.26120621
46MP0005023_abnormal_wound_healing1.25475231
47MP0003690_abnormal_glial_cell1.25230878
48MP0002932_abnormal_joint_morphology1.25060962
49MP0002092_abnormal_eye_morphology1.24630905
50MP0001243_abnormal_dermal_layer1.24360086
51MP0000163_abnormal_cartilage_morphology1.20819080
52MP0004883_abnormal_blood_vessel1.20740059
53MP0002233_abnormal_nose_morphology1.20221813
54MP0006138_congestive_heart_failure1.20122856
55MP0003385_abnormal_body_wall1.18889010
56MP0008961_abnormal_basal_metabolism1.18515413
57MP0004036_abnormal_muscle_relaxation1.16881830
58MP0001293_anophthalmia1.16274393
59MP0004087_abnormal_muscle_fiber1.14500056
60MP0009840_abnormal_foam_cell1.13362815
61MP0000767_abnormal_smooth_muscle1.13306964
62MP0000759_abnormal_skeletal_muscle1.12713390
63MP0002896_abnormal_bone_mineralization1.12626851
64MP0002249_abnormal_larynx_morphology1.11869347
65MP0005380_embryogenesis_phenotype1.11236078
66MP0001672_abnormal_embryogenesis/_devel1.11236078
67MP0002088_abnormal_embryonic_growth/wei1.11090561
68MP0000432_abnormal_head_morphology1.10714444
69MP0003075_altered_response_to1.10189484
70MP0005275_abnormal_skin_tensile1.10082715
71MP0003938_abnormal_ear_development1.09666504
72MP0005595_abnormal_vascular_smooth1.09622222
73MP0003984_embryonic_growth_retardation1.09562660
74MP0005330_cardiomyopathy1.08661556
75MP0004084_abnormal_cardiac_muscle1.08189028
76MP0000003_abnormal_adipose_tissue1.07445222
77MP0002909_abnormal_adrenal_gland1.06470830
78MP0004233_abnormal_muscle_weight1.06188583
79MP0003121_genomic_imprinting1.05361857
80MP0006035_abnormal_mitochondrial_morpho1.04254012
81MP0003283_abnormal_digestive_organ1.04229613
82MP0005164_abnormal_response_to1.02151084
83MP0005670_abnormal_white_adipose1.01704708
84MP0001270_distended_abdomen1.01067305
85MP0000678_abnormal_parathyroid_gland1.00885135
86MP0003942_abnormal_urinary_system0.98701627
87MP0000733_abnormal_muscle_development0.98430219
88MP0002877_abnormal_melanocyte_morpholog0.97290549
89MP0000749_muscle_degeneration0.96882963
90MP0002089_abnormal_postnatal_growth/wei0.95637357
91MP0009250_abnormal_appendicular_skeleto0.94920724
92MP0002970_abnormal_white_adipose0.93555203
93MP0009115_abnormal_fat_cell0.92968696
94MP0003935_abnormal_craniofacial_develop0.92388913
95MP0001915_intracranial_hemorrhage0.92320130
96MP0009053_abnormal_anal_canal0.91978519
97MP0000462_abnormal_digestive_system0.91593542
98MP0002086_abnormal_extraembryonic_tissu0.91547810
99MP0003755_abnormal_palate_morphology0.91395845
100MP0005197_abnormal_uvea_morphology0.91147355
101MP0005620_abnormal_muscle_contractility0.91055032
102MP0002128_abnormal_blood_circulation0.90188994
103* MP0002925_abnormal_cardiovascular_devel0.89669132
104MP0002116_abnormal_craniofacial_bone0.88693344
105MP0003115_abnormal_respiratory_system0.88399111
106MP0002114_abnormal_axial_skeleton0.87976608
107MP0000647_abnormal_sebaceous_gland0.86692614
108MP0002697_abnormal_eye_size0.86369683
109MP0005076_abnormal_cell_differentiation0.86276365
110MP0001958_emphysema0.85692401
111MP0005391_vision/eye_phenotype0.85350268
112MP0005165_increased_susceptibility_to0.84463129
113MP0003329_amyloid_beta_deposits0.83966172
114MP0003950_abnormal_plasma_membrane0.83796141
115MP0005369_muscle_phenotype0.83336576
116MP0005666_abnormal_adipose_tissue0.82278591
117MP0002295_abnormal_pulmonary_circulatio0.81351193
118MP0000537_abnormal_urethra_morphology0.80701245
119MP0002108_abnormal_muscle_morphology0.80505163
120MP0009672_abnormal_birth_weight0.80326376
121MP0002972_abnormal_cardiac_muscle0.79783391
122MP0003937_abnormal_limbs/digits/tail_de0.78663430
123MP0003634_abnormal_glial_cell0.77112443
124* MP0001614_abnormal_blood_vessel0.76706490
125MP0002269_muscular_atrophy0.75904539
126MP0003172_abnormal_lysosome_physiology0.75863631
127* MP0003566_abnormal_cell_adhesion0.75470278
128MP0010630_abnormal_cardiac_muscle0.74534834
129MP0009780_abnormal_chondrocyte_physiolo0.74182482
130MP0002109_abnormal_limb_morphology0.73861476
131MP0008770_decreased_survivor_rate0.73471317
132MP0005390_skeleton_phenotype0.72762183
133MP0005409_darkened_coat_color0.71749893
134MP0001348_abnormal_lacrimal_gland0.71555140
135MP0005193_abnormal_anterior_eye0.71097915
136MP0000534_abnormal_ureter_morphology0.70786024
137MP0003186_abnormal_redox_activity0.70752342
138MP0004133_heterotaxia0.70297760
139MP0003878_abnormal_ear_physiology0.70274934
140MP0005377_hearing/vestibular/ear_phenot0.70274934
141MP0000266_abnormal_heart_morphology0.70259454
142MP0000467_abnormal_esophagus_morphology0.69722617
143MP0001661_extended_life_span0.68026379
144MP0000747_muscle_weakness0.67399634
145MP0002106_abnormal_muscle_physiology0.67368501
146MP0001175_abnormal_lung_morphology0.66344264
147MP0005375_adipose_tissue_phenotype0.66297462
148MP0002085_abnormal_embryonic_tissue0.65550110
149MP0002115_abnormal_skeleton_extremities0.65061579
150MP0005058_abnormal_lysosome_morphology0.64546900
151MP0002933_joint_inflammation0.62985237
152MP0002113_abnormal_skeleton_development0.62953707
153MP0002111_abnormal_tail_morphology0.59664123
154MP0002998_abnormal_bone_remodeling0.59373431

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.84913835
2Hepatoblastoma (HP:0002884)4.95626218
3Type 1 muscle fiber predominance (HP:0003803)4.45254417
4Multiple enchondromatosis (HP:0005701)4.42407549
5Aortic aneurysm (HP:0004942)4.21227818
6Aortic dissection (HP:0002647)4.14019394
7Shallow orbits (HP:0000586)4.06122460
8Bladder diverticulum (HP:0000015)3.83407611
9Soft skin (HP:0000977)3.82898402
10Hypochromic microcytic anemia (HP:0004840)3.80008267
11Spinal rigidity (HP:0003306)3.75764777
12Abnormality of dentin (HP:0010299)3.70965211
13Vascular tortuosity (HP:0004948)3.69952279
14Ependymoma (HP:0002888)3.63775579
15Atrophic scars (HP:0001075)3.45555924
16Follicular hyperkeratosis (HP:0007502)3.42275223
17Rib fusion (HP:0000902)3.38883644
18Increased variability in muscle fiber diameter (HP:0003557)3.29984185
19Genu recurvatum (HP:0002816)3.28546329
20Fragile skin (HP:0001030)3.28149104
21Wormian bones (HP:0002645)3.20863730
22Arterial tortuosity (HP:0005116)3.19387429
23Biconcave vertebral bodies (HP:0004586)3.14808074
24Slender build (HP:0001533)3.11003239
25Abnormality of the lower motor neuron (HP:0002366)3.08782937
26Pseudobulbar signs (HP:0002200)3.05233959
27Increased connective tissue (HP:0009025)2.96166296
28Bowel diverticulosis (HP:0005222)2.94571041
29Blue sclerae (HP:0000592)2.94048217
30Aplasia involving bones of the extremities (HP:0009825)2.92325570
31Aplasia involving bones of the upper limbs (HP:0009823)2.92325570
32Aplasia of the phalanges of the hand (HP:0009802)2.92325570
33Protrusio acetabuli (HP:0003179)2.89643387
34Abnormality of skeletal muscle fiber size (HP:0012084)2.88360129
35Dilatation of the ascending aorta (HP:0005111)2.86177199
36Testicular atrophy (HP:0000029)2.83827311
37Vertebral compression fractures (HP:0002953)2.81090730
38Fused cervical vertebrae (HP:0002949)2.79978315
39Abnormality of the astrocytes (HP:0100707)2.79270794
40Astrocytoma (HP:0009592)2.79270794
41Abnormality of the salivary glands (HP:0010286)2.78143758
42Abnormal cartilage morphology (HP:0002763)2.77626070
43Selective tooth agenesis (HP:0001592)2.77578851
44Difficulty running (HP:0009046)2.74718662
45Partial duplication of thumb phalanx (HP:0009944)2.73034363
46Neonatal short-limb short stature (HP:0008921)2.72174587
47Premature rupture of membranes (HP:0001788)2.66487618
48Ragged-red muscle fibers (HP:0003200)2.62498700
49Hypoventilation (HP:0002791)2.58788680
50Disproportionate tall stature (HP:0001519)2.58060549
51Joint laxity (HP:0001388)2.54975670
52Mitral regurgitation (HP:0001653)2.51136636
53Hypoplastic scapulae (HP:0000882)2.50340500
54Aplasia/Hypoplasia of the scapulae (HP:0006713)2.50340500
55Partial duplication of the phalanx of hand (HP:0009999)2.47357920
56Hyperextensible skin (HP:0000974)2.46146735
57Turricephaly (HP:0000262)2.44694449
58Elbow flexion contracture (HP:0002987)2.43141093
59Mildly elevated creatine phosphokinase (HP:0008180)2.42957542
60Ectopia lentis (HP:0001083)2.41801011
61Back pain (HP:0003418)2.41582711
62Coronal craniosynostosis (HP:0004440)2.39234971
63Trismus (HP:0000211)2.38574093
64Preauricular skin tag (HP:0000384)2.38152945
65Peritonitis (HP:0002586)2.38082990
66Short humerus (HP:0005792)2.37612542
67Abnormality of liposaccharide metabolism (HP:0010968)2.36322054
68Abnormality of glycosphingolipid metabolism (HP:0004343)2.36322054
69Abnormality of glycolipid metabolism (HP:0010969)2.36322054
70Abnormality of the pubic bones (HP:0003172)2.36046397
71Nasolacrimal duct obstruction (HP:0000579)2.34391282
72Neoplasm of striated muscle (HP:0009728)2.32548539
73Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.32432190
74Wide anterior fontanel (HP:0000260)2.32247618
75Aneurysm (HP:0002617)2.31367304
76Abnormal delivery (HP:0001787)2.30525355
77Short 5th finger (HP:0009237)2.27633664
78Round ear (HP:0100830)2.27021869
79Overgrowth (HP:0001548)2.26500773
80Aplasia/hypoplasia of the humerus (HP:0006507)2.25255298
81Aplasia/Hypoplasia of the fovea (HP:0008060)2.22655768
82Hypoplasia of the fovea (HP:0007750)2.22655768
83Premature skin wrinkling (HP:0100678)2.22521492
84Aortic regurgitation (HP:0001659)2.22397719
85Abnormality of the distal phalanx of the thumb (HP:0009617)2.22218785
86Hyperinsulinemic hypoglycemia (HP:0000825)2.21325833
87Bifid tongue (HP:0010297)2.17429636
88Hyperacusis (HP:0010780)2.16421049
89Multifactorial inheritance (HP:0001426)2.16244581
90Radial bowing (HP:0002986)2.12731498
91Breech presentation (HP:0001623)2.12045321
92Skin tags (HP:0010609)2.11781325
93Nephroblastoma (Wilms tumor) (HP:0002667)2.10045858
94Broad alveolar ridges (HP:0000187)2.09935246
95Distal lower limb amyotrophy (HP:0008944)2.09711708
96Ulnar bowing (HP:0003031)2.08863796
97Horizontal nystagmus (HP:0000666)2.08576268
98Glossoptosis (HP:0000162)2.05872399
99Spondylolisthesis (HP:0003302)2.05651169
100Distal lower limb muscle weakness (HP:0009053)2.05621749
101Embryonal renal neoplasm (HP:0011794)2.05295813
102Absent frontal sinuses (HP:0002688)2.05287129
103Abnormality of the acetabulum (HP:0003170)2.03559120
104Nonimmune hydrops fetalis (HP:0001790)2.01895023
105Joint stiffness (HP:0001387)2.01496803
106Mild short stature (HP:0003502)2.01267267
107Generalized amyotrophy (HP:0003700)2.00336075
108Hand muscle atrophy (HP:0009130)1.98942323
109Aortic valve stenosis (HP:0001650)1.98936415
110Wrist flexion contracture (HP:0001239)1.98816120
111Megalencephaly (HP:0001355)1.98624890
112Camptodactyly of toe (HP:0001836)1.97828473
113Hemiparesis (HP:0001269)1.97401201
114Lower limb amyotrophy (HP:0007210)1.96529229
115Short middle phalanx of the 5th finger (HP:0004220)1.96268059
116Limb-girdle muscle weakness (HP:0003325)1.95379603
117Osteolytic defects of the hand bones (HP:0009699)1.94058403
118Osteolytic defects of the phalanges of the hand (HP:0009771)1.94058403
119Large earlobe (HP:0009748)1.92977610
120Thin ribs (HP:0000883)1.92796119
121Rhabdomyosarcoma (HP:0002859)1.91971007
122Mesangial abnormality (HP:0001966)1.91647553
123Generalized hypotonia (HP:0001290)1.91516275
124Natal tooth (HP:0000695)1.91408874
125Glioma (HP:0009733)1.90769210
126Broad long bones (HP:0005622)1.88913675
127Protruding ear (HP:0000411)1.88144281
128Stridor (HP:0010307)1.87957336
129Obstructive sleep apnea (HP:0002870)1.87831000
130Deviation of the hallux (HP:0010051)1.87305056
131Cervical subluxation (HP:0003308)1.86820050
132Long toe (HP:0010511)1.85415315
133Bowing of the arm (HP:0006488)1.85238965
134Bowed forearm bones (HP:0003956)1.85238965
135Neoplasm of the heart (HP:0100544)1.84443301
136Shawl scrotum (HP:0000049)1.84360501
137Persistence of primary teeth (HP:0006335)1.83424666
138Broad metatarsal (HP:0001783)1.82114011
139Broad ribs (HP:0000885)1.81251791
140Anomalous pulmonary venous return (HP:0010772)1.80800168
141Abnormality of chromosome segregation (HP:0002916)1.80641293
142Mitral valve prolapse (HP:0001634)1.79972127
143Achilles tendon contracture (HP:0001771)1.79813817
144Short middle phalanx of finger (HP:0005819)1.79646992
145Cerebral aneurysm (HP:0004944)1.79033608
146Skin nodule (HP:0200036)1.78391553
147Inguinal hernia (HP:0000023)1.77966374
148Flat capital femoral epiphysis (HP:0003370)1.77512454
149Upper limb amyotrophy (HP:0009129)1.77020413
150Distal upper limb amyotrophy (HP:0007149)1.77020413
151Hyperglycinuria (HP:0003108)1.76656330
152Lymphangioma (HP:0100764)1.76362161
153Ankle contracture (HP:0006466)1.75887647
154Hypopigmentation of the fundus (HP:0007894)1.75848091
155Preaxial foot polydactyly (HP:0001841)1.75831390
156Arnold-Chiari malformation (HP:0002308)1.75474381
157Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.75383022
158Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.74892698
159Abnormality of the Achilles tendon (HP:0005109)1.74366950
160Abnormality of the musculature of the hand (HP:0001421)1.74260561
161Morphological abnormality of the middle ear (HP:0008609)1.74108617
162Abnormality of the fovea (HP:0000493)1.73901298
163Hip contracture (HP:0003273)1.73773940
164Flat cornea (HP:0007720)1.73428727
165Preauricular pit (HP:0004467)1.72988121
166Periauricular skin pits (HP:0100277)1.72988121
167Choanal stenosis (HP:0000452)1.72029275
168Short hallux (HP:0010109)1.71966611
169Missing ribs (HP:0000921)1.71619972
170Abnormality of the distal phalanges of the toes (HP:0010182)1.71525549
171Abnormality of the lacrimal duct (HP:0011481)1.71052548
172Renal duplication (HP:0000075)1.70719789
173Scotoma (HP:0000575)1.70367160
174Supernumerary nipples (HP:0002558)1.70312233
175Ventricular tachycardia (HP:0004756)1.70035492
176Delayed cranial suture closure (HP:0000270)1.69767289
177Hallux valgus (HP:0001822)1.69368559
178Arachnodactyly (HP:0001166)1.67292332
179Muscle fiber splitting (HP:0003555)1.66490682
180Limited hip movement (HP:0008800)1.65563066
181Redundant skin (HP:0001582)1.65154177

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.31245107
2ERN15.29178827
3GRK53.54550389
4MATK3.38377430
5GRK63.07542303
6SIK13.07330648
7TGFBR22.99392292
8LMTK22.86287704
9TRIB32.77872289
10TYRO32.56713906
11SMG12.45181983
12MAPK72.41671339
13EPHA22.36415795
14CSF1R2.22216302
15GRK12.08613332
16TESK12.07824744
17EEF2K2.01885283
18STK101.92997663
19CDC42BPA1.83064290
20LIMK11.74119132
21MOS1.73174486
22ADRBK21.66809324
23PHKG21.64220262
24PHKG11.64220262
25ICK1.58406956
26DDR21.55884831
27NTRK11.55547122
28FGFR41.52979809
29PDGFRA1.49284952
30PRKG21.44089621
31PAK41.43410576
32FGFR31.43014928
33WNK11.41960939
34GRK71.41835136
35TTK1.37489892
36MAP3K61.30597240
37FLT31.27926046
38NEK91.21826979
39BMX1.20935941
40PRKD31.20839928
41EPHA41.19871630
42RIPK11.18901325
43MAPK121.17514234
44DAPK31.17194723
45CAMK41.14665090
46ERBB41.11792835
47PIK3CG1.09100037
48ADRBK11.07428520
49RPS6KA21.06981089
50TTN1.01233558
51ROCK10.96616338
52ROCK20.95638246
53MARK20.93424153
54PTK20.87964609
55CDK70.86396757
56LATS20.83858659
57ILK0.83243637
58MAP3K70.82230990
59PRPF4B0.79827552
60HIPK20.79416007
61PAK30.75283804
62CAMK1D0.73895140
63ERBB20.68458367
64AKT20.67579563
65RPS6KC10.67025543
66RPS6KL10.67025543
67IGF1R0.65885060
68TRPM70.65163437
69EPHB10.61554600
70KSR20.60900314
71PKN20.59701859
72LATS10.59319835
73CSK0.58732835
74PDK30.58052526
75PDK40.58052526
76KDR0.57549750
77MTOR0.55458839
78LRRK20.55443637
79PDK20.55174344
80TAOK20.52296872
81STK38L0.51384883
82ABL20.50693360
83NTRK20.49549317
84ARAF0.48871765
85MAP3K80.48039249
86PRKD20.45813058
87RPS6KA60.44785970
88MUSK0.44343766
89MET0.43957347
90NEK20.42488451
91PDGFRB0.41806658
92KIT0.41711734
93PTK60.41042136
94MAP2K30.40781686
95CAMK1G0.40726485
96PAK20.40602277
97MAP2K40.39641020
98CAMK2G0.39483067
99CHEK20.39276620
100INSR0.39117634
101MAP3K100.38268988
102FER0.37601500
103DYRK1B0.36517857
104STK380.36087944
105BCKDK0.34686526
106ALK0.34657907
107PTK2B0.34052136
108CLK10.32568326
109STK40.32205952
110CDK90.32054750
111CAMK2D0.30127567
112RPS6KB20.29546125
113BRAF0.29522523
114MST40.29393002
115MAP2K60.29099014
116FGFR20.29006509
117MELK0.28787866
118AKT30.28317144
119SRC0.28025861
120EPHB20.27342656
121EGFR0.24310778
122DMPK0.23686480
123DYRK1A0.23520051
124MAPK40.23512485
125PRKD10.23358066
126MAPKAPK20.23318265
127FGFR10.23187856
128CDK11A0.22992935
129CAMK10.22947515
130PRKCD0.22749048
131PAK10.22330521
132MYLK0.22295932
133PRKAA20.22242840
134PLK10.21543178
135PRKACG0.20827251
136MAPKAPK30.19698319
137PRKAA10.18970671
138MAPK10.18546232
139CHEK10.18427386
140FGR0.18405175
141STK30.17975821
142GSK3A0.17330629
143CDK40.14468788
144TIE10.14210797
145MAP3K30.13638093

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.69589399
2Fatty acid biosynthesis_Homo sapiens_hsa000614.51137625
3Vitamin B6 metabolism_Homo sapiens_hsa007503.56020350
4Fructose and mannose metabolism_Homo sapiens_hsa000513.53144215
5Galactose metabolism_Homo sapiens_hsa000522.96405741
6Nitrogen metabolism_Homo sapiens_hsa009102.13729457
7Fatty acid metabolism_Homo sapiens_hsa012121.91399046
8ECM-receptor interaction_Homo sapiens_hsa045121.87966654
9Glycosaminoglycan degradation_Homo sapiens_hsa005311.80105562
10PPAR signaling pathway_Homo sapiens_hsa033201.75508070
11Arachidonic acid metabolism_Homo sapiens_hsa005901.64537109
12Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.58256726
13Basal cell carcinoma_Homo sapiens_hsa052171.56743036
14Other glycan degradation_Homo sapiens_hsa005111.43212350
15Caffeine metabolism_Homo sapiens_hsa002321.42339116
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.42031557
17Fatty acid degradation_Homo sapiens_hsa000711.41272189
18Focal adhesion_Homo sapiens_hsa045101.39448746
19Melanogenesis_Homo sapiens_hsa049161.38313701
20Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.36880190
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33922868
22Proteoglycans in cancer_Homo sapiens_hsa052051.33685827
23Bladder cancer_Homo sapiens_hsa052191.33288671
24Malaria_Homo sapiens_hsa051441.29319559
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.26683093
26Pentose phosphate pathway_Homo sapiens_hsa000301.26573652
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.26112534
28Melanoma_Homo sapiens_hsa052181.23251959
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22323957
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.21018261
31Chronic myeloid leukemia_Homo sapiens_hsa052201.20262544
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19399749
33Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.19205393
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.18390099
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12413927
36Hippo signaling pathway_Homo sapiens_hsa043901.11360418
37Adherens junction_Homo sapiens_hsa045201.10919411
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.10636729
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.09562611
40Protein digestion and absorption_Homo sapiens_hsa049741.09507251
41Axon guidance_Homo sapiens_hsa043601.08419058
42Prion diseases_Homo sapiens_hsa050201.07799104
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.06970234
44Prostate cancer_Homo sapiens_hsa052151.06747930
45Carbon metabolism_Homo sapiens_hsa012001.06111281
46mTOR signaling pathway_Homo sapiens_hsa041501.06053698
47Regulation of actin cytoskeleton_Homo sapiens_hsa048101.03843640
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01745626
49Lysosome_Homo sapiens_hsa041421.00419837
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.99634513
51Dilated cardiomyopathy_Homo sapiens_hsa054140.98765303
52Thyroid hormone signaling pathway_Homo sapiens_hsa049190.98247235
53Small cell lung cancer_Homo sapiens_hsa052220.97397749
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95897420
55cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95788024
56Notch signaling pathway_Homo sapiens_hsa043300.91643443
57Pathways in cancer_Homo sapiens_hsa052000.91460319
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.90137088
59Glioma_Homo sapiens_hsa052140.89432815
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89248278
61Hedgehog signaling pathway_Homo sapiens_hsa043400.88780309
62Gap junction_Homo sapiens_hsa045400.88416430
63Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.87724623
64Longevity regulating pathway - mammal_Homo sapiens_hsa042110.87544002
65Biosynthesis of amino acids_Homo sapiens_hsa012300.86887978
66Rap1 signaling pathway_Homo sapiens_hsa040150.86858367
67Lysine degradation_Homo sapiens_hsa003100.86395673
68MicroRNAs in cancer_Homo sapiens_hsa052060.85255120
69Thyroid cancer_Homo sapiens_hsa052160.84913115
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84775358
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.80575748
72Pancreatic cancer_Homo sapiens_hsa052120.80378711
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.80111820
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79188778
75African trypanosomiasis_Homo sapiens_hsa051430.76883880
76Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.76810968
77Steroid biosynthesis_Homo sapiens_hsa001000.76370758
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.76051555
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75795909
80Insulin signaling pathway_Homo sapiens_hsa049100.74285156
81Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.72264001
82Insulin resistance_Homo sapiens_hsa049310.71635577
83N-Glycan biosynthesis_Homo sapiens_hsa005100.71171822
84Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67259521
85Estrogen signaling pathway_Homo sapiens_hsa049150.67072578
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67029558
87Glycerolipid metabolism_Homo sapiens_hsa005610.64373050
88Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64080459
89Tight junction_Homo sapiens_hsa045300.63555770
90Neurotrophin signaling pathway_Homo sapiens_hsa047220.61004689
91AMPK signaling pathway_Homo sapiens_hsa041520.58866583
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58497459
93Non-small cell lung cancer_Homo sapiens_hsa052230.57703444
94Propanoate metabolism_Homo sapiens_hsa006400.56884488
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56506156
96Sulfur relay system_Homo sapiens_hsa041220.56166834
97GnRH signaling pathway_Homo sapiens_hsa049120.55997014
98Linoleic acid metabolism_Homo sapiens_hsa005910.55659727
99TGF-beta signaling pathway_Homo sapiens_hsa043500.53808930
100Thyroid hormone synthesis_Homo sapiens_hsa049180.53467919
101Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52990355
102Ovarian steroidogenesis_Homo sapiens_hsa049130.51435845
103Renal cell carcinoma_Homo sapiens_hsa052110.51130207
104ErbB signaling pathway_Homo sapiens_hsa040120.49903030
105Amoebiasis_Homo sapiens_hsa051460.49454618
106Glucagon signaling pathway_Homo sapiens_hsa049220.48974399
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48657827
108HIF-1 signaling pathway_Homo sapiens_hsa040660.48583307
109p53 signaling pathway_Homo sapiens_hsa041150.48136607
110Ras signaling pathway_Homo sapiens_hsa040140.47980941
111Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.47666675
112Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47479924
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.47237307
114Vibrio cholerae infection_Homo sapiens_hsa051100.47112554
115Sphingolipid signaling pathway_Homo sapiens_hsa040710.46520515
116Shigellosis_Homo sapiens_hsa051310.46228105
117Choline metabolism in cancer_Homo sapiens_hsa052310.43755098
118Acute myeloid leukemia_Homo sapiens_hsa052210.43572434
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.43013518
120MAPK signaling pathway_Homo sapiens_hsa040100.42841796
121Selenocompound metabolism_Homo sapiens_hsa004500.42683619
122Wnt signaling pathway_Homo sapiens_hsa043100.38372752
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38062547
124cAMP signaling pathway_Homo sapiens_hsa040240.37979169
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37890251
126Endocytosis_Homo sapiens_hsa041440.37845894
127Toxoplasmosis_Homo sapiens_hsa051450.37457390
128Apoptosis_Homo sapiens_hsa042100.36254417
129Starch and sucrose metabolism_Homo sapiens_hsa005000.34776671
130Ether lipid metabolism_Homo sapiens_hsa005650.34042146
131Platelet activation_Homo sapiens_hsa046110.32599407
132VEGF signaling pathway_Homo sapiens_hsa043700.31876256
133Chemical carcinogenesis_Homo sapiens_hsa052040.31369262
134Renin-angiotensin system_Homo sapiens_hsa046140.30055949
135Endometrial cancer_Homo sapiens_hsa052130.29924178
136HTLV-I infection_Homo sapiens_hsa051660.28762357
137Dorso-ventral axis formation_Homo sapiens_hsa043200.27779528
138Inositol phosphate metabolism_Homo sapiens_hsa005620.27368654
139Colorectal cancer_Homo sapiens_hsa052100.27068386

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »