MFHAS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Identified in a human 8p amplicon, this gene is a potential oncogene whose expression is enhanced in some malignant fibrous histiocytomas (MFH). The primary structure of its product includes an ATP/GTP-binding site, three leucine zipper domains, and a leucine-rich tandem repeat, which are structural or functional elements for interactions among proteins related to the cell cycle, and which suggest that overexpression might be oncogenic with respect to MFH. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)4.75144641
2pre-miRNA processing (GO:0031054)4.70106169
3heterochromatin organization (GO:0070828)4.41803709
4cellular protein complex localization (GO:0034629)4.22621800
5nuclear pore organization (GO:0006999)4.05920102
6mitotic sister chromatid cohesion (GO:0007064)3.97263801
7mitotic chromosome condensation (GO:0007076)3.91017751
8DNA unwinding involved in DNA replication (GO:0006268)3.89722318
9protein localization to chromosome, centromeric region (GO:0071459)3.78716911
10regulation of histone H3-K9 methylation (GO:0051570)3.78045451
11protein complex localization (GO:0031503)3.75970011
12protein localization to kinetochore (GO:0034501)3.75280773
13negative regulation of histone methylation (GO:0031061)3.74742818
14pore complex assembly (GO:0046931)3.73736898
15branching involved in labyrinthine layer morphogenesis (GO:0060670)3.66106208
16regulation of cytokine secretion involved in immune response (GO:0002739)3.64956352
17regulation of vitamin D biosynthetic process (GO:0060556)3.61676921
18DNA topological change (GO:0006265)3.42053653
19regulation of RNA export from nucleus (GO:0046831)3.29713350
20folic acid-containing compound biosynthetic process (GO:0009396)3.29156531
21DNA strand elongation involved in DNA replication (GO:0006271)3.25620011
22regulation of chronic inflammatory response (GO:0002676)3.18779560
23DNA strand elongation (GO:0022616)3.16331867
24DNA replication checkpoint (GO:0000076)3.14384392
25mitotic metaphase plate congression (GO:0007080)3.12359058
26CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.11210657
27regulation of NFAT protein import into nucleus (GO:0051532)3.05650407
28protoporphyrinogen IX metabolic process (GO:0046501)3.05405834
29mitotic G2/M transition checkpoint (GO:0044818)3.05353548
30positive regulation of chromosome segregation (GO:0051984)3.04853317
31cardiac myofibril assembly (GO:0055003)3.02959598
32L-alpha-amino acid transmembrane transport (GO:1902475)2.99737025
33T cell lineage commitment (GO:0002360)2.97645511
34regulation of nucleobase-containing compound transport (GO:0032239)2.96085326
35cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92020694
36positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.90503124
37regulation of interferon-alpha production (GO:0032647)2.86843872
38mitotic nuclear envelope disassembly (GO:0007077)2.86056199
39plasma membrane repair (GO:0001778)2.84833018
40histone H3-K36 demethylation (GO:0070544)2.84320658
41nuclear envelope disassembly (GO:0051081)2.83327053
42membrane disassembly (GO:0030397)2.83327053
43DNA replication initiation (GO:0006270)2.81374657
44regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.79708341
45negative regulation of translation, ncRNA-mediated (GO:0040033)2.79573194
46regulation of translation, ncRNA-mediated (GO:0045974)2.79573194
47negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79573194
48regulation of vitamin metabolic process (GO:0030656)2.79039321
49negative regulation of DNA repair (GO:0045738)2.78411386
50dicarboxylic acid biosynthetic process (GO:0043650)2.76851509
51mitotic G2 DNA damage checkpoint (GO:0007095)2.76780968
52telomere maintenance via semi-conservative replication (GO:0032201)2.75169875
53sister chromatid segregation (GO:0000819)2.74294538
54negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.74247044
55mitotic sister chromatid segregation (GO:0000070)2.74232594
56antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.74181866
57positive regulation of natural killer cell differentiation (GO:0032825)2.73517701
58growth hormone receptor signaling pathway (GO:0060396)2.73433370
59establishment of integrated proviral latency (GO:0075713)2.72220072
60cell communication involved in cardiac conduction (GO:0086065)2.70174145
61regulation of podosome assembly (GO:0071801)2.67783510
62modulation by symbiont of host cellular process (GO:0044068)2.67136617
63cellular response to virus (GO:0098586)2.64906099
64regulation of stem cell maintenance (GO:2000036)2.64169447
65chromatin remodeling at centromere (GO:0031055)2.64148104
66trophoblast giant cell differentiation (GO:0060707)2.63137907
67positive regulation of SMAD protein import into nucleus (GO:0060391)2.62685947
68regulation of chromatin binding (GO:0035561)2.62503116
69regulation of interleukin-2 biosynthetic process (GO:0045076)2.61529329
70IMP biosynthetic process (GO:0006188)2.61004358
71myofibril assembly (GO:0030239)2.58272239
72metaphase plate congression (GO:0051310)2.55494949
73regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.55118747
74regulation of mitotic metaphase/anaphase transition (GO:0030071)2.55118747
75cell communication by electrical coupling (GO:0010644)2.54889041
76sarcomere organization (GO:0045214)2.54162416
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.54104261
78regulation of fever generation (GO:0031620)2.53989860
79regulation of posttranscriptional gene silencing (GO:0060147)2.51807326
80regulation of gene silencing by miRNA (GO:0060964)2.51807326
81regulation of gene silencing by RNA (GO:0060966)2.51807326
82activation of MAPKKK activity (GO:0000185)2.50556478
83cardiac muscle contraction (GO:0060048)2.50510723
84CENP-A containing nucleosome assembly (GO:0034080)2.49309311
85telomere maintenance via recombination (GO:0000722)2.49167284
86negative regulation of chromosome segregation (GO:0051985)2.49050353
87negative regulation of interleukin-12 production (GO:0032695)2.48991083
88regulation of sister chromatid cohesion (GO:0007063)2.48286928
89DNA duplex unwinding (GO:0032508)2.48237005
90regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.48133777
91DNA replication-independent nucleosome assembly (GO:0006336)2.48000474
92DNA replication-independent nucleosome organization (GO:0034724)2.48000474
932-oxoglutarate metabolic process (GO:0006103)2.47814277
94regulation of nuclear cell cycle DNA replication (GO:0033262)2.46179140
95regulation of chromosome segregation (GO:0051983)2.45829164
96regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.45737124
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.45335549
98mitotic recombination (GO:0006312)2.44786569
99positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.44392842
100IMP metabolic process (GO:0046040)2.42458294
101RNA stabilization (GO:0043489)2.42384093
102mRNA stabilization (GO:0048255)2.42384093
103ribosomal small subunit biogenesis (GO:0042274)2.42274004
104protoporphyrinogen IX biosynthetic process (GO:0006782)2.42229497
105purine nucleobase biosynthetic process (GO:0009113)2.41483143
106positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.41204075
107positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.41204075
108positive regulation of mitotic sister chromatid separation (GO:1901970)2.41204075
109regulation of sister chromatid segregation (GO:0033045)2.40127188
110regulation of mitotic sister chromatid separation (GO:0010965)2.40127188
111regulation of mitotic sister chromatid segregation (GO:0033047)2.40127188
112negative regulation of potassium ion transmembrane transport (GO:1901380)2.39929843
113negative regulation of DNA-dependent DNA replication (GO:2000104)2.37771615
114lysine catabolic process (GO:0006554)2.37627357
115lysine metabolic process (GO:0006553)2.37627357
116negative regulation of fibroblast apoptotic process (GO:2000270)2.37017652
117negative regulation of mitotic sister chromatid segregation (GO:0033048)2.36019670
118regulation of interleukin-12 biosynthetic process (GO:0045075)2.33381033
119sodium ion export (GO:0071436)2.31048557
120regulation of dendritic cell antigen processing and presentation (GO:0002604)2.29880909
121cardiac muscle hypertrophy (GO:0003300)2.25302814
122phospholipid homeostasis (GO:0055091)2.24952702
123negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.24317014
124bundle of His cell to Purkinje myocyte communication (GO:0086069)2.23994721
125cellular response to growth hormone stimulus (GO:0071378)2.23933163
126fatty acid transmembrane transport (GO:1902001)2.22710985
127muscle hypertrophy (GO:0014896)2.21923646
128negative regulation of cell killing (GO:0031342)2.21885706
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.21885706
130JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.17959989
131cell adhesion mediated by integrin (GO:0033627)2.13468256
132striated muscle hypertrophy (GO:0014897)2.12457934
133negative thymic T cell selection (GO:0045060)2.11075394
134cellular response to prostaglandin stimulus (GO:0071379)2.10729051
135regulation of actin filament-based movement (GO:1903115)2.08932113
136positive regulation of muscle hypertrophy (GO:0014742)2.07568430
137positive regulation of cardiac muscle hypertrophy (GO:0010613)2.07568430
138negative T cell selection (GO:0043383)2.06960595
139regulation of relaxation of muscle (GO:1901077)2.06589116
140regulation of the force of heart contraction (GO:0002026)2.06223843
141positive regulation of macrophage cytokine production (GO:0060907)2.04570002
142carnitine shuttle (GO:0006853)2.04349876
143kynurenine metabolic process (GO:0070189)2.04252181
144regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.03904342
145regulation of cholesterol storage (GO:0010885)2.03396643
146antigen processing and presentation of endogenous antigen (GO:0019883)2.02367541
147membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.02098056
148positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.01963080
149ventricular cardiac muscle cell action potential (GO:0086005)2.01691830
150regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.01299553
151relaxation of cardiac muscle (GO:0055119)1.99835566
152response to prostaglandin E (GO:0034695)1.97384378
153regulation of cell communication by electrical coupling (GO:0010649)1.97020770
154positive regulation of gamma-delta T cell activation (GO:0046645)1.97003610
155negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.96696767
156locomotory exploration behavior (GO:0035641)1.96512349
157regulation of T-helper 1 cell differentiation (GO:0045625)1.95973492
158triglyceride-rich lipoprotein particle remodeling (GO:0034370)1.95746596
159positive regulation of glycogen biosynthetic process (GO:0045725)1.93368726
160desmosome organization (GO:0002934)1.93055292
161regulation of vascular endothelial growth factor signaling pathway (GO:1900746)1.92237317
162cellular ketone body metabolic process (GO:0046950)1.91345673
163regulation of p38MAPK cascade (GO:1900744)1.89734860
164neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)1.89344087
165thymic T cell selection (GO:0045061)1.88694685
166regulation of ARF protein signal transduction (GO:0032012)1.88495223
167positive regulation of lipid storage (GO:0010884)1.87431273
168positive regulation of humoral immune response (GO:0002922)1.86818250
169substrate-dependent cell migration (GO:0006929)1.86724073
170NIK/NF-kappaB signaling (GO:0038061)1.86410207
171regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)1.86314413
172regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)1.86029307
173regulation of synapse structural plasticity (GO:0051823)1.85287001
174oxaloacetate metabolic process (GO:0006107)1.84096353
175myeloid dendritic cell differentiation (GO:0043011)1.83871096
176activation of protein kinase A activity (GO:0034199)1.83612330
177I-kappaB phosphorylation (GO:0007252)1.83302455
178positive regulation of membrane protein ectodomain proteolysis (GO:0051044)1.82978533
179cardiac muscle hypertrophy in response to stress (GO:0014898)1.82978126
180muscle hypertrophy in response to stress (GO:0003299)1.82978126
181cardiac muscle adaptation (GO:0014887)1.82978126
182synaptic vesicle maturation (GO:0016188)1.82836728
183insulin-like growth factor receptor signaling pathway (GO:0048009)1.82747400
184antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.82623685
185antigen processing and presentation of endogenous peptide antigen (GO:0002483)1.82623685
186positive regulation of antigen processing and presentation (GO:0002579)1.82025569
187positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.81381111
188positive regulation of fatty acid beta-oxidation (GO:0032000)1.81378208
189endocytic recycling (GO:0032456)1.81376813
190T cell selection (GO:0045058)1.80416469
191positive regulation of p38MAPK cascade (GO:1900745)1.80298212
192actomyosin structure organization (GO:0031032)1.80140532
193cardiac conduction (GO:0061337)1.80077781
194phospholipid efflux (GO:0033700)1.79553856
195urea metabolic process (GO:0019627)1.79511926
196urea cycle (GO:0000050)1.79511926

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.70988188
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.35718016
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.64973181
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63723695
5MYC_22102868_ChIP-Seq_BL_Human3.22477220
6MYC_18555785_ChIP-Seq_MESCs_Mouse2.84868226
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.81272057
8AR_21909140_ChIP-Seq_LNCAP_Human2.58931263
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57423068
10KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.51953899
11KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.51953899
12KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.51953899
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.45293465
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.32923496
15ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.32028110
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.25929111
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.18116191
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.17601583
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.11049798
20KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.06096036
21NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03076265
22PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.02375523
23SMAD_19615063_ChIP-ChIP_OVARY_Human2.00532943
24POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90143016
25NELFA_20434984_ChIP-Seq_ESCs_Mouse1.88208130
26IRF8_22096565_ChIP-ChIP_GC-B_Human1.87518756
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.81844410
28RXR_22158963_ChIP-Seq_LIVER_Mouse1.81685925
29* LXR_22158963_ChIP-Seq_LIVER_Mouse1.78012050
30* SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74283956
31EP300_21415370_ChIP-Seq_HL-1_Mouse1.71629195
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.63211521
33CDX2_19796622_ChIP-Seq_MESCs_Mouse1.62789755
34MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60981763
35TP63_17297297_ChIP-ChIP_HaCaT_Human1.60843640
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.59699655
37CREB1_15753290_ChIP-ChIP_HEK293T_Human1.58954883
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.57723256
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54429144
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.54300908
41MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.53344545
42IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.53136756
43* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.52263675
44* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51246770
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.50834416
46* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.50493601
47RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.50233225
48SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.50217727
49ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48420154
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48284215
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.48266823
52RNF2_18974828_ChIP-Seq_MESCs_Mouse1.48266823
53* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.48089997
54FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.47652687
55* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.47479670
56AR_21572438_ChIP-Seq_LNCaP_Human1.46250115
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.44205172
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.43742884
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43530676
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.43196290
61DROSHA_22980978_ChIP-Seq_HELA_Human1.42782428
62ESR1_20079471_ChIP-ChIP_T-47D_Human1.42614248
63KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40581476
64TCF7_22412390_ChIP-Seq_EML_Mouse1.40182260
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40007440
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39235747
67* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.38752157
68TRIM28_21343339_ChIP-Seq_HEK293_Human1.38724134
69TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.38568590
70ESR2_21235772_ChIP-Seq_MCF-7_Human1.38179253
71* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.38153944
72* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.37722365
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36905658
74TCF3_18692474_ChIP-Seq_MEFs_Mouse1.36503203
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36483466
76BP1_19119308_ChIP-ChIP_Hs578T_Human1.35668219
77VDR_24787735_ChIP-Seq_THP-1_Human1.33836123
78EST1_17652178_ChIP-ChIP_JURKAT_Human1.33634768
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32881328
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32777953
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.32663465
82SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.32574586
83CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30149773
84STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30085727
85* IRF8_27001747_Chip-Seq_BMDM_Mouse1.28855650
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.28155416
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.27621855
88* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.27168407
89TFEB_21752829_ChIP-Seq_HELA_Human1.27061806
90KDM2B_26808549_Chip-Seq_K562_Human1.26317797
91RUNX_20019798_ChIP-Seq_JUKART_Human1.26195532
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25886436
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.23864137
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.23501008
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.22117030
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21760415
97NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21706651
98E2F1_18555785_ChIP-Seq_MESCs_Mouse1.21143760
99NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.21020542
100BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21007839
101CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.20300285
102TBX20_22080862_ChIP-Seq_HEART_Mouse1.20293751
103TBX20_22328084_ChIP-Seq_HEART_Mouse1.20293751
104AHR_22903824_ChIP-Seq_MCF-7_Human1.19923736
105BRD4_27068464_Chip-Seq_AML-cells_Mouse1.19367678
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17006829
107SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16906227
108ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15480982
109EZH2_27294783_Chip-Seq_ESCs_Mouse1.15379572
110VDR_21846776_ChIP-Seq_THP-1_Human1.15095389
111* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14741373
112GATA2_21666600_ChIP-Seq_HMVEC_Human1.14605108
113MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14554777
114CLOCK_20551151_ChIP-Seq_293T_Human1.14390821
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14248288
116SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.11794502
117IKZF1_21737484_ChIP-ChIP_HCT116_Human1.11635824
118SUZ12_27294783_Chip-Seq_ESCs_Mouse1.11381656
119CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.10619152
120THAP11_20581084_ChIP-Seq_MESCs_Mouse1.10445639
121TP63_19390658_ChIP-ChIP_HaCaT_Human1.09700350
122EZH2_22144423_ChIP-Seq_EOC_Human1.09593426
123EED_16625203_ChIP-ChIP_MESCs_Mouse1.08889679
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.08588581
125RXR_22108803_ChIP-Seq_LS180_Human1.08463161
126EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08012871
127RNF2_27304074_Chip-Seq_ESCs_Mouse1.07804666
128NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07670874
129NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07670874
130CJUN_26792858_Chip-Seq_BT549_Human1.06911444
131DCP1A_22483619_ChIP-Seq_HELA_Human1.06879329
132FOXP3_21729870_ChIP-Seq_TREG_Human1.06608079
133STAT6_21828071_ChIP-Seq_BEAS2B_Human1.05537218
134TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05485511
135MAF_26560356_Chip-Seq_TH1_Human1.05376943
136* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05067906
137MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04819650
138KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04534759
139TP53_18474530_ChIP-ChIP_U2OS_Human1.03446900
140GATA1_19941826_ChIP-Seq_K562_Human1.03396955
141KDM2B_26808549_Chip-Seq_DND41_Human1.02421800
142PU_27001747_Chip-Seq_BMDM_Mouse1.02006950
143CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01494608
144SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01248176
145WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01239076
146POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.00010658
147TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99741356
148ARNT_22903824_ChIP-Seq_MCF-7_Human0.99590285
149* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98997493
150TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98982254
151FOXO3_23340844_ChIP-Seq_DLD1_Human0.98839326
152PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98120758
153WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.97822484
154TP53_16413492_ChIP-PET_HCT116_Human0.97227757
155TCF3_18692474_ChIP-Seq_MESCs_Mouse0.97079135
156CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96436534
157EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95962050
158XRN2_22483619_ChIP-Seq_HELA_Human0.95806254
159* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95787997
160* FOXA2_19822575_ChIP-Seq_HepG2_Human0.95031110
161MYB_26560356_Chip-Seq_TH1_Human0.94813097
162NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94318161
163* SMAD4_21741376_ChIP-Seq_HESCs_Human0.94301524
164E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93172200
165NANOG_21062744_ChIP-ChIP_HESCs_Human0.93058901
166SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.92009071
167EZH2_27304074_Chip-Seq_ESCs_Mouse0.91971768
168GATA1_22025678_ChIP-Seq_K562_Human0.91611708
169SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90982754
170KDM2B_26808549_Chip-Seq_JURKAT_Human0.90536036
171GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89771029
172SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89562139
173SOX2_18555785_ChIP-Seq_MESCs_Mouse0.89321955
174SMAD3_21741376_ChIP-Seq_HESCs_Human0.88819649
175ESR1_21235772_ChIP-Seq_MCF-7_Human0.88592688
176SMAD4_21799915_ChIP-Seq_A2780_Human0.88298925
177GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87445261
178ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87043198
179ZNF263_19887448_ChIP-Seq_K562_Human0.86294481
180OCT4_18692474_ChIP-Seq_MEFs_Mouse0.86122408
181* LXR_22292898_ChIP-Seq_THP-1_Human0.86059739
182GBX2_23144817_ChIP-Seq_PC3_Human0.85431544
183NCOR1_26117541_ChIP-Seq_K562_Human0.85159415
184GATA2_19941826_ChIP-Seq_K562_Human0.84208961
185BCAT_22108803_ChIP-Seq_LS180_Human0.83861184
186EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83676309

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004510_myositis3.98013075
2MP0008057_abnormal_DNA_replication3.86111569
3MP0003693_abnormal_embryo_hatching3.04661449
4MP0003111_abnormal_nucleus_morphology2.99945898
5MP0003941_abnormal_skin_development2.92482939
6MP0010352_gastrointestinal_tract_polyps2.79548023
7MP0003890_abnormal_embryonic-extraembry2.71935899
8MP0002138_abnormal_hepatobiliary_system2.62597432
9MP0004957_abnormal_blastocyst_morpholog2.61636289
10MP0003656_abnormal_erythrocyte_physiolo2.55467536
11MP0004084_abnormal_cardiac_muscle2.53667456
12MP0005360_urolithiasis2.53054119
13MP0010094_abnormal_chromosome_stability2.44669555
14MP0002837_dystrophic_cardiac_calcinosis2.42811161
15MP0003453_abnormal_keratinocyte_physiol2.36968743
16MP0005076_abnormal_cell_differentiation2.27946302
17MP0003303_peritoneal_inflammation2.23616890
18MP0003705_abnormal_hypodermis_morpholog2.21943894
19MP0003077_abnormal_cell_cycle2.11751135
20MP0002254_reproductive_system_inflammat2.07372996
21MP0002139_abnormal_hepatobiliary_system2.05844844
22MP0004858_abnormal_nervous_system2.00907673
23MP0004859_abnormal_synaptic_plasticity1.99288703
24MP0008775_abnormal_heart_ventricle1.96456202
25MP0000751_myopathy1.95078805
26MP0004215_abnormal_myocardial_fiber1.91119903
27MP0002972_abnormal_cardiac_muscle1.87004971
28MP0001730_embryonic_growth_arrest1.86225507
29MP0004130_abnormal_muscle_cell1.84002573
30MP0010307_abnormal_tumor_latency1.83172100
31MP0001835_abnormal_antigen_presentation1.82197778
32MP0009278_abnormal_bone_marrow1.81272737
33MP0005085_abnormal_gallbladder_physiolo1.79270515
34MP0003436_decreased_susceptibility_to1.77912596
35MP0009333_abnormal_splenocyte_physiolog1.74089340
36MP0003646_muscle_fatigue1.71036229
37MP0003252_abnormal_bile_duct1.67871451
38MP0004185_abnormal_adipocyte_glucose1.65415088
39MP0004808_abnormal_hematopoietic_stem1.64384039
40MP0000685_abnormal_immune_system1.63965749
41MP0004036_abnormal_muscle_relaxation1.59440636
42MP0001348_abnormal_lacrimal_gland1.57900460
43MP0000490_abnormal_crypts_of1.57228111
44MP0000350_abnormal_cell_proliferation1.56073888
45MP0003763_abnormal_thymus_physiology1.55747755
46MP0002735_abnormal_chemical_nociception1.55098241
47MP0000604_amyloidosis1.54381637
48MP0001790_abnormal_immune_system1.53833995
49MP0005387_immune_system_phenotype1.53833995
50MP0005310_abnormal_salivary_gland1.53701378
51MP0009672_abnormal_birth_weight1.51771866
52MP0000569_abnormal_digit_pigmentation1.50382519
53MP0003300_gastrointestinal_ulcer1.49237721
54MP0005330_cardiomyopathy1.48701727
55MP0005083_abnormal_biliary_tract1.47908736
56MP0001544_abnormal_cardiovascular_syste1.46737737
57MP0005385_cardiovascular_system_phenoty1.46737737
58MP0001545_abnormal_hematopoietic_system1.43959489
59MP0005397_hematopoietic_system_phenotyp1.43959489
60MP0002796_impaired_skin_barrier1.40746919
61MP0005671_abnormal_response_to1.38179609
62MP0008007_abnormal_cellular_replicative1.37820583
63MP0006138_congestive_heart_failure1.35308817
64MP0004087_abnormal_muscle_fiber1.33798018
65MP0003123_paternal_imprinting1.32168854
66MP0003566_abnormal_cell_adhesion1.32005045
67MP0002398_abnormal_bone_marrow1.31870614
68MP0005167_abnormal_blood-brain_barrier1.30855830
69MP0004484_altered_response_of1.30509501
70MP0010630_abnormal_cardiac_muscle1.29178197
71MP0005365_abnormal_bile_salt1.27930448
72MP0000749_muscle_degeneration1.26619696
73MP0009840_abnormal_foam_cell1.26527009
74MP0008058_abnormal_DNA_repair1.26130454
75MP0003828_pulmonary_edema1.25959581
76MP0002405_respiratory_system_inflammati1.24559997
77MP0009764_decreased_sensitivity_to1.23154159
78MP0003279_aneurysm1.22914779
79MP0002148_abnormal_hypersensitivity_rea1.21646693
80MP0001697_abnormal_embryo_size1.21002121
81MP0001672_abnormal_embryogenesis/_devel1.20341567
82MP0005380_embryogenesis_phenotype1.20341567
83MP0008961_abnormal_basal_metabolism1.20142338
84MP0003091_abnormal_cell_migration1.19398602
85MP0000313_abnormal_cell_death1.18221558
86MP0008004_abnormal_stomach_pH1.17895192
87MP0005000_abnormal_immune_tolerance1.17421050
88MP0003984_embryonic_growth_retardation1.16079786
89MP0000689_abnormal_spleen_morphology1.15898411
90MP0005620_abnormal_muscle_contractility1.15582616
91MP0008932_abnormal_embryonic_tissue1.14822316
92MP0002088_abnormal_embryonic_growth/wei1.14681262
93MP0000703_abnormal_thymus_morphology1.13284449
94MP0003191_abnormal_cellular_cholesterol1.12683188
95MP0004947_skin_inflammation1.11299330
96MP0003448_altered_tumor_morphology1.10757436
97MP0002877_abnormal_melanocyte_morpholog1.10500166
98MP0002722_abnormal_immune_system1.10359849
99MP0010368_abnormal_lymphatic_system1.08273509
100MP0005058_abnormal_lysosome_morphology1.06623628
101MP0004085_abnormal_heartbeat1.06094969
102MP0002166_altered_tumor_susceptibility1.04085376
103MP0001968_abnormal_touch/_nociception1.03774359
104MP0002998_abnormal_bone_remodeling1.01128844
105MP0000343_altered_response_to1.01058359
106MP0002080_prenatal_lethality1.00311518
107MP0002086_abnormal_extraembryonic_tissu0.99944345
108MP0003137_abnormal_impulse_conducting0.99344551
109MP0003075_altered_response_to0.97932653
110MP0000716_abnormal_immune_system0.97495300
111MP0000767_abnormal_smooth_muscle0.97269198
112MP0001819_abnormal_immune_cell0.97247976
113MP0005166_decreased_susceptibility_to0.96507570
114MP0002420_abnormal_adaptive_immunity0.96320202
115MP0001879_abnormal_lymphatic_vessel0.96022388
116MP0002396_abnormal_hematopoietic_system0.95948390
117MP0010329_abnormal_lipoprotein_level0.95090904
118MP0002429_abnormal_blood_cell0.95077860
119MP0008874_decreased_physiological_sensi0.94121432
120MP0008877_abnormal_DNA_methylation0.93738628
121MP0002009_preneoplasia0.93288540
122MP0002419_abnormal_innate_immunity0.91965089
123MP0002736_abnormal_nociception_after0.91854911
124MP0005647_abnormal_sex_gland0.91626910
125MP0005332_abnormal_amino_acid0.91371353
126MP0006082_CNS_inflammation0.90605035
127MP0003635_abnormal_synaptic_transmissio0.90507341
128MP0009785_altered_susceptibility_to0.90357162
129MP0010155_abnormal_intestine_physiology0.90092790
130MP0003329_amyloid_beta_deposits0.89444526
131MP0001849_ear_inflammation0.89363239
132MP0001800_abnormal_humoral_immune0.88855001
133MP0002085_abnormal_embryonic_tissue0.87575616
134MP0009703_decreased_birth_body0.86606222
135MP0005621_abnormal_cell_physiology0.86594821
136MP0005275_abnormal_skin_tensile0.86267871
137MP0003690_abnormal_glial_cell0.85294941
138MP0005535_abnormal_body_temperature0.85019892
139MP0001533_abnormal_skeleton_physiology0.84946633
140MP0001216_abnormal_epidermal_layer0.83668145
141MP0008875_abnormal_xenobiotic_pharmacok0.82991077
142MP0003045_fibrosis0.81644278
143MP0001915_intracranial_hemorrhage0.81037678
144MP0002084_abnormal_developmental_patter0.80187288
145MP0002452_abnormal_antigen_presenting0.79967148
146MP0005025_abnormal_response_to0.79070091
147MP0010234_abnormal_vibrissa_follicle0.78639435
148MP0002006_tumorigenesis0.78592047
149MP0004264_abnormal_extraembryonic_tissu0.78526760
150MP0002933_joint_inflammation0.78213065
151MP0003567_abnormal_fetal_cardiomyocyte0.77991935
152MP0005501_abnormal_skin_physiology0.77787227
153MP0005584_abnormal_enzyme/coenzyme_acti0.77427248
154MP0009046_muscle_twitch0.77061958
155MP0004270_analgesia0.76669219
156MP0001845_abnormal_inflammatory_respons0.75064976
157MP0001853_heart_inflammation0.75063229
158MP0001958_emphysema0.74914900
159MP0000609_abnormal_liver_physiology0.74617365
160MP0002063_abnormal_learning/memory/cond0.74558293
161MP0002019_abnormal_tumor_incidence0.74204923
162MP0002909_abnormal_adrenal_gland0.71882139
163MP0003172_abnormal_lysosome_physiology0.71566199
164MP0002118_abnormal_lipid_homeostasis0.70710704
165MP0000858_altered_metastatic_potential0.70469330
166MP0005451_abnormal_body_composition0.70463705
167MP0003633_abnormal_nervous_system0.69893263
168MP0005666_abnormal_adipose_tissue0.69276876
169MP0001756_abnormal_urination0.69215201
170MP0002723_abnormal_immune_serum0.68990831
171MP0000249_abnormal_blood_vessel0.68938503

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)4.68311562
2Multiple enchondromatosis (HP:0005701)3.63733362
3Right ventricular cardiomyopathy (HP:0011663)3.36844890
4Ventricular tachycardia (HP:0004756)3.24036221
5Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21920786
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.21731009
7Myocardial infarction (HP:0001658)3.09115542
8Chromsome breakage (HP:0040012)3.06493562
9Atrial fibrillation (HP:0005110)3.06116140
10Disinhibition (HP:0000734)3.05909811
11Cortical dysplasia (HP:0002539)3.02128934
12Gastrointestinal carcinoma (HP:0002672)2.91991499
13Malignant gastrointestinal tract tumors (HP:0006749)2.91991499
14Nephroblastoma (Wilms tumor) (HP:0002667)2.90940648
15Primary atrial arrhythmia (HP:0001692)2.89724385
16Deep venous thrombosis (HP:0002625)2.86291986
17Syncope (HP:0001279)2.81831849
18IgA deficiency (HP:0002720)2.78741626
19Leiomyosarcoma (HP:0100243)2.78270316
20Uterine leiomyosarcoma (HP:0002891)2.78270316
21Poikilocytosis (HP:0004447)2.76339819
22Transitional cell carcinoma of the bladder (HP:0006740)2.75250036
23Eczematoid dermatitis (HP:0000976)2.73884840
24Embryonal renal neoplasm (HP:0011794)2.70376460
25Hyporeflexia of lower limbs (HP:0002600)2.69941571
26Supraventricular tachycardia (HP:0004755)2.64557186
27Asymmetric septal hypertrophy (HP:0001670)2.64005963
28Reticulocytopenia (HP:0001896)2.63861290
29Abnormality of chromosome stability (HP:0003220)2.61779697
30Agnosia (HP:0010524)2.61250625
31Supraventricular arrhythmia (HP:0005115)2.61170983
32Recurrent gram-negative bacterial infections (HP:0005420)2.55460607
33Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.53816454
34Xanthomatosis (HP:0000991)2.53201148
35Systemic lupus erythematosus (HP:0002725)2.51204897
36Bladder carcinoma (HP:0002862)2.50425407
37Bladder neoplasm (HP:0009725)2.50425407
38Abnormality of the fingertips (HP:0001211)2.50167782
39Complement deficiency (HP:0004431)2.46335254
40Exercise-induced muscle cramps (HP:0003710)2.44793227
41Supranuclear gaze palsy (HP:0000605)2.43544773
42Abnormality of glutamine family amino acid metabolism (HP:0010902)2.42509502
43Conjunctival hamartoma (HP:0100780)2.38074740
44Exercise-induced myalgia (HP:0003738)2.37739766
45Lipoatrophy (HP:0100578)2.35988282
46Septo-optic dysplasia (HP:0100842)2.34575915
47Abnormality of the calf musculature (HP:0001430)2.34264952
48Bundle branch block (HP:0011710)2.34238089
49Cerebral aneurysm (HP:0004944)2.33822693
50Prolonged QT interval (HP:0001657)2.32368953
51Limb hypertonia (HP:0002509)2.31248080
52Spastic diplegia (HP:0001264)2.30718876
53Meckel diverticulum (HP:0002245)2.30700103
54Hydroxyprolinuria (HP:0003080)2.30572460
55Abnormality of proline metabolism (HP:0010907)2.30572460
56Progressive external ophthalmoplegia (HP:0000590)2.30087931
57Ventricular arrhythmia (HP:0004308)2.25235272
58Abnormality of the heme biosynthetic pathway (HP:0010472)2.24944152
59Thick nail (HP:0001805)2.24541294
60Calf muscle hypertrophy (HP:0008981)2.22635731
61T lymphocytopenia (HP:0005403)2.21865732
62Mitral stenosis (HP:0001718)2.21804200
63Axonal loss (HP:0003447)2.21415239
64Inappropriate behavior (HP:0000719)2.20496082
65Esophageal varix (HP:0002040)2.19559862
66Subacute progressive viral hepatitis (HP:0006572)2.18998706
67Deep palmar crease (HP:0006191)2.18911786
68Myokymia (HP:0002411)2.18601822
69Dysmetric saccades (HP:0000641)2.18404864
70Ventricular fibrillation (HP:0001663)2.16623819
71Lymphangioma (HP:0100764)2.16514631
72Abnormality of the ileum (HP:0001549)2.16285873
73Cerebral hemorrhage (HP:0001342)2.15878137
74Recurrent viral infections (HP:0004429)2.13954684
75Uterine neoplasm (HP:0010784)2.12329730
76Dysphonia (HP:0001618)2.09641031
77IgM deficiency (HP:0002850)2.09375305
78Autoimmune hemolytic anemia (HP:0001890)2.08914279
79Increased connective tissue (HP:0009025)2.08182400
80Abnormal hair whorl (HP:0010721)2.06448239
81Colon cancer (HP:0003003)2.05463715
82Action tremor (HP:0002345)2.05203554
83Ketoacidosis (HP:0001993)2.01962444
84Homocystinuria (HP:0002156)2.01450591
85Abnormality of homocysteine metabolism (HP:0010919)2.01450591
86Birth length less than 3rd percentile (HP:0003561)2.00940502
87Embryonal neoplasm (HP:0002898)1.99248684
88Polycythemia (HP:0001901)1.98921308
89Increased IgM level (HP:0003496)1.98907516
90Abnormality of the preputium (HP:0100587)1.98714322
91Acute lymphatic leukemia (HP:0006721)1.98518453
92Aortic aneurysm (HP:0004942)1.98392453
93Mitral valve prolapse (HP:0001634)1.96183502
94Hepatoblastoma (HP:0002884)1.95953006
95Bilateral sensorineural hearing impairment (HP:0008619)1.95145708
96Ankyloglossia (HP:0010296)1.94133996
97Myotonia (HP:0002486)1.93730686
98Abnormality of T cell number (HP:0011839)1.93674392
99Long palpebral fissure (HP:0000637)1.93633031
100Hematochezia (HP:0002573)1.93331870
101Pheochromocytoma (HP:0002666)1.92918714
102Abnormal atrioventricular conduction (HP:0005150)1.92682947
103Acanthocytosis (HP:0001927)1.92544760
104Hamartoma of the eye (HP:0010568)1.92261900
105Heart block (HP:0012722)1.91632065
106EMG: myopathic abnormalities (HP:0003458)1.91621296
107Nephritis (HP:0000123)1.91403712
108Atrioventricular block (HP:0001678)1.91262003
109Combined immunodeficiency (HP:0005387)1.91245092
110Subaortic stenosis (HP:0001682)1.90551130
111Abnormality of the left ventricular outflow tract (HP:0011103)1.90551130
112Choanal stenosis (HP:0000452)1.89454843
113Short middle phalanx of the 5th finger (HP:0004220)1.89355591
114Skull defect (HP:0001362)1.88997104
115Autoimmune thrombocytopenia (HP:0001973)1.88079193
116Asymmetry of the thorax (HP:0001555)1.87321175
117Increased nuchal translucency (HP:0010880)1.86805918
118Cafe-au-lait spot (HP:0000957)1.86764654
119Abnormality of reticulocytes (HP:0004312)1.86141228
120Peritonitis (HP:0002586)1.85741799
121Amaurosis fugax (HP:0100576)1.85622982
122Long toe (HP:0010511)1.85451134
123Hyperlipoproteinemia (HP:0010980)1.85376535
124Sudden cardiac death (HP:0001645)1.85257329
125Neoplasm of the adrenal cortex (HP:0100641)1.84774720
126Paralysis (HP:0003470)1.84758676
127Hypoalphalipoproteinemia (HP:0003233)1.84159970
128Abnormality of complement system (HP:0005339)1.81974083
129Selective tooth agenesis (HP:0001592)1.81873695
130Cellular immunodeficiency (HP:0005374)1.81501210
131Abnormality of the salivary glands (HP:0010286)1.81322859
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.80969850
133Wide nose (HP:0000445)1.80862290
134Abnormality of cells of the lymphoid lineage (HP:0012140)1.80726526
135Abnormality of the septum pellucidum (HP:0007375)1.80365323
136Lymphopenia (HP:0001888)1.80172252
137Carpal bone hypoplasia (HP:0001498)1.79639888
138Hepatocellular carcinoma (HP:0001402)1.79501223
139Myoglobinuria (HP:0002913)1.78579153
140Abnormality of the lumbar spine (HP:0100712)1.78504891
141Palpitations (HP:0001962)1.78464519
142Abnormality of the vasculature of the conjunctiva (HP:0008054)1.77649941
143Ketosis (HP:0001946)1.77513811
144Long eyelashes (HP:0000527)1.77505581
145Neonatal hypoglycemia (HP:0001998)1.77207847
146Skin nodule (HP:0200036)1.76222808
147Osteomyelitis (HP:0002754)1.75933312
148Thoracic kyphosis (HP:0002942)1.75799738
149Muscle hypertrophy of the lower extremities (HP:0008968)1.74836900
150Renal cell carcinoma (HP:0005584)1.74800154
151Maternal diabetes (HP:0009800)1.74233431
152Rhabdomyosarcoma (HP:0002859)1.74158627
153Thickened helices (HP:0000391)1.73864011
154Pallor (HP:0000980)1.73767628
155Recurrent bacterial skin infections (HP:0005406)1.72769784
156Epidermoid cyst (HP:0200040)1.72479684
157Cleft eyelid (HP:0000625)1.71485993
158Intrahepatic cholestasis (HP:0001406)1.70720161
159Abnormality of the thoracic spine (HP:0100711)1.70362484
160Optic neuritis (HP:0100653)1.70061643
161Retrobulbar optic neuritis (HP:0100654)1.70061643
162Anal stenosis (HP:0002025)1.69074551
163Dilated cardiomyopathy (HP:0001644)1.66845386
164Aneurysm (HP:0002617)1.66590702
165Urethral obstruction (HP:0000796)1.66139212
166Abnormality of the Achilles tendon (HP:0005109)1.65825654
167Arterial thrombosis (HP:0004420)1.65477583
168Stroke (HP:0001297)1.65397339
169Joint hemorrhage (HP:0005261)1.64855032
170Lower limb amyotrophy (HP:0007210)1.64399892
171Lymphoma (HP:0002665)1.64355374
172Abnormal lung lobation (HP:0002101)1.64326830
173Glomerulonephritis (HP:0000099)1.63345706
174Short middle phalanx of finger (HP:0005819)1.63089793
175Hypochromic microcytic anemia (HP:0004840)1.62950055
176Abnormality of glycosphingolipid metabolism (HP:0004343)1.62799828
177Cavernous hemangioma (HP:0001048)1.62576566
178Overgrowth (HP:0001548)1.61253955
179Recurrent fungal infections (HP:0002841)1.60522842
180Increased cerebral lipofuscin (HP:0011813)1.59368603
181Persistence of primary teeth (HP:0006335)1.58815534
182Mediastinal lymphadenopathy (HP:0100721)1.58247056
183Muscle fiber splitting (HP:0003555)1.57989500
184Lower limb asymmetry (HP:0100559)1.57488441
185Neuroendocrine neoplasm (HP:0100634)1.56788327
186Striae distensae (HP:0001065)1.55604965
187Sensorimotor neuropathy (HP:0007141)1.55342743
188Focal seizures (HP:0007359)1.55176415
189Frequent falls (HP:0002359)1.55142081
190Distal lower limb muscle weakness (HP:0009053)1.54423210
191Ectopia lentis (HP:0001083)1.54226066
192Abnormal EKG (HP:0003115)1.53848913
193Dilatation of the ascending aorta (HP:0005111)1.53783848

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B3.40821088
2CDC72.82326554
3MAP3K142.67119847
4TRIB32.61115728
5IRAK32.60572733
6PKN22.15968688
7TTK2.13361255
8TAOK22.09996674
9BUB12.06821922
10TTN2.06566419
11JAK12.04346450
12EEF2K2.02594366
13CDK121.99466175
14SMG11.98704073
15TYK21.98567641
16RIPK11.90915157
17TSSK61.90020502
18EIF2AK11.87764402
19RIPK41.87712517
20FGFR41.87410116
21MST41.85264549
22JAK31.80381644
23NME21.77202213
24TAF11.66537688
25TBK11.62349839
26MAP3K91.61063839
27SIK11.58511264
28ACVR1B1.56130658
29CLK11.55503218
30DYRK31.54250781
31SIK21.52549500
32MAP3K131.52539857
33EPHA31.50045591
34DMPK1.48806244
35MKNK21.48667131
36STK241.42789716
37LMTK21.42690770
38PHKG11.41834919
39PHKG21.41834919
40FGFR31.41397478
41EIF2AK31.36060942
42PASK1.35696141
43CDK41.35547183
44MKNK11.34813072
45TYRO31.34537578
46PLK41.31524852
47RET1.30479419
48SGK31.29518028
49BRAF1.28010491
50PTK61.26921975
51PLK31.26226261
52NLK1.23641560
53ICK1.21133061
54STK41.20302087
55MAP3K71.18379986
56DAPK21.17895771
57KSR21.17626269
58MAP3K81.15310554
59TGFBR21.14301986
60MYLK1.13389832
61MINK11.09878582
62PRKCH1.09470894
63NTRK31.07522399
64SGK21.07274016
65TNIK1.07074978
66PIM11.06110459
67JAK21.05994506
68FGR1.04827230
69SRPK11.04587645
70MELK1.02421632
71STK101.01766522
72MAP2K40.99437814
73IKBKE0.98835101
74CAMK1G0.98055628
75CHUK0.97444095
76MAP4K10.97440188
77BRD40.97304910
78PBK0.96141270
79EPHB10.93357412
80ERN10.92596614
81CHEK20.91755785
82WEE10.91466561
83NTRK20.90124939
84CAMK1D0.89927659
85CAMKK10.89307479
86STK160.88153611
87OBSCN0.86451380
88IKBKB0.85367478
89NTRK10.84442646
90PIK3CA0.84160464
91NEK90.83575299
92STK380.83368873
93CDK60.83206247
94MARK30.83043196
95PTK2B0.82836000
96MARK10.82160805
97PAK30.80003481
98STK30.79922493
99ALK0.79619744
100MST1R0.79394019
101TAOK10.78373381
102PKN10.77859809
103CHEK10.77830417
104MATK0.77282484
105MAPK120.76833824
106PDGFRA0.76235667
107GRK50.75152331
108ZAK0.74770013
109LRRK20.73771424
110SIK30.73070953
111PLK10.72220269
112BMX0.71745009
113PAK60.71739442
114GRK70.71230154
115PRKCQ0.70597865
116IRAK40.70595168
117CAMK40.70064896
118MAP3K20.69432995
119MAP3K50.68943650
120HCK0.68587588
121RPS6KA20.68191683
122EPHB20.68190664
123SGK4940.67447867
124SGK2230.67447867
125ARAF0.67424250
126DDR20.66761020
127CDC42BPA0.65643825
128WNK10.65231755
129IRAK20.64637446
130TRPM70.64426611
131ROCK10.64373389
132ATR0.61968281
133MAP3K10.60817685
134PRKD10.58895252
135MTOR0.58846488
136PNCK0.58385190
137YES10.58326204
138SGK10.58124830
139MAP3K100.57797181
140CDK70.57645660
141EGFR0.57069705
142PDK10.56590600
143NEK10.56435339
144ATM0.56189587
145FGFR20.55776565
146ITK0.55566494
147INSRR0.55417870
148PRKAA20.55105108
149EIF2AK20.53280252
150FER0.53196179
151MAP2K30.53052932
152MAP3K40.52288889
153FGFR10.51527096
154STK110.51342331
155BLK0.51297921
156LATS20.50580385
157PDPK10.50038341
158PDGFRB0.49583522
159PRKCZ0.49153090
160TGFBR10.48845829
161MAP3K30.47982816
162PLK20.47103327
163SYK0.45757388
164TXK0.45166620
165PRKCE0.44131155
166DAPK30.43998385
167CDK50.43671747
168CDK20.42933740
169CSK0.39588592
170MAP3K110.38817245
171CDK90.37750269
172RPS6KB20.37122666
173PAK40.36881991
174KSR10.34890853

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.44381918
2DNA replication_Homo sapiens_hsa030303.11420030
3Cell cycle_Homo sapiens_hsa041102.61774303
4Mismatch repair_Homo sapiens_hsa034302.58499083
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.49409293
6Nitrogen metabolism_Homo sapiens_hsa009102.27006581
7Non-homologous end-joining_Homo sapiens_hsa034501.85164187
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.83755478
9Spliceosome_Homo sapiens_hsa030401.79957082
10Arginine biosynthesis_Homo sapiens_hsa002201.74259376
11mRNA surveillance pathway_Homo sapiens_hsa030151.56712348
12RNA transport_Homo sapiens_hsa030131.56351736
13MicroRNAs in cancer_Homo sapiens_hsa052061.53845246
14Herpes simplex infection_Homo sapiens_hsa051681.52551130
15Staphylococcus aureus infection_Homo sapiens_hsa051501.51070394
16Epstein-Barr virus infection_Homo sapiens_hsa051691.49561432
17Thyroid cancer_Homo sapiens_hsa052161.49408645
18Dilated cardiomyopathy_Homo sapiens_hsa054141.48555998
19Prostate cancer_Homo sapiens_hsa052151.45292689
20Hepatitis B_Homo sapiens_hsa051611.44525944
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.43365290
22Influenza A_Homo sapiens_hsa051641.42367100
23Base excision repair_Homo sapiens_hsa034101.36614193
24Bladder cancer_Homo sapiens_hsa052191.35833186
25Primary bile acid biosynthesis_Homo sapiens_hsa001201.34451043
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32596261
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31221628
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28358618
29Ribosome_Homo sapiens_hsa030101.27857685
30Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25400774
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24238861
32Apoptosis_Homo sapiens_hsa042101.24089698
33Hepatitis C_Homo sapiens_hsa051601.23019493
34Fatty acid degradation_Homo sapiens_hsa000711.21947316
35Complement and coagulation cascades_Homo sapiens_hsa046101.18917224
36Bile secretion_Homo sapiens_hsa049761.17414776
37Osteoclast differentiation_Homo sapiens_hsa043801.16633714
38Homologous recombination_Homo sapiens_hsa034401.15339154
39HTLV-I infection_Homo sapiens_hsa051661.11584367
40Viral myocarditis_Homo sapiens_hsa054161.10664659
41One carbon pool by folate_Homo sapiens_hsa006701.10406605
42Leishmaniasis_Homo sapiens_hsa051401.09506020
43p53 signaling pathway_Homo sapiens_hsa041151.06120712
44Viral carcinogenesis_Homo sapiens_hsa052031.05591303
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.05193444
46Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.04158886
47Renal cell carcinoma_Homo sapiens_hsa052111.03587580
48Type II diabetes mellitus_Homo sapiens_hsa049301.02921269
49Notch signaling pathway_Homo sapiens_hsa043301.00464924
50PPAR signaling pathway_Homo sapiens_hsa033201.00391660
51Tryptophan metabolism_Homo sapiens_hsa003800.99459118
52Toll-like receptor signaling pathway_Homo sapiens_hsa046200.98745703
53Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98454010
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.96729640
55Insulin resistance_Homo sapiens_hsa049310.96386275
56Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96124387
57Non-small cell lung cancer_Homo sapiens_hsa052230.95256169
58Toxoplasmosis_Homo sapiens_hsa051450.93524865
59Adherens junction_Homo sapiens_hsa045200.93377521
60Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.93366933
61Cardiac muscle contraction_Homo sapiens_hsa042600.92785061
62RNA degradation_Homo sapiens_hsa030180.92237217
63Nucleotide excision repair_Homo sapiens_hsa034200.91930936
64TNF signaling pathway_Homo sapiens_hsa046680.91520505
65Legionellosis_Homo sapiens_hsa051340.90163057
66Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88112653
67Basal transcription factors_Homo sapiens_hsa030220.85951630
68Other glycan degradation_Homo sapiens_hsa005110.85686151
69Steroid biosynthesis_Homo sapiens_hsa001000.84789412
70Chemokine signaling pathway_Homo sapiens_hsa040620.84185749
71Small cell lung cancer_Homo sapiens_hsa052220.83931211
72Pancreatic cancer_Homo sapiens_hsa052120.83795472
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.83536797
74Tuberculosis_Homo sapiens_hsa051520.83363953
75Asthma_Homo sapiens_hsa053100.82778025
76Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82730061
77Primary immunodeficiency_Homo sapiens_hsa053400.82626218
78Gastric acid secretion_Homo sapiens_hsa049710.82599676
79NF-kappa B signaling pathway_Homo sapiens_hsa040640.82144240
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82042870
81Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82040300
82Dorso-ventral axis formation_Homo sapiens_hsa043200.81684571
83Fatty acid metabolism_Homo sapiens_hsa012120.80946461
84Renin secretion_Homo sapiens_hsa049240.80455812
85Autoimmune thyroid disease_Homo sapiens_hsa053200.80395988
86Hematopoietic cell lineage_Homo sapiens_hsa046400.80290357
87Prolactin signaling pathway_Homo sapiens_hsa049170.79996079
88Circadian entrainment_Homo sapiens_hsa047130.78528598
89B cell receptor signaling pathway_Homo sapiens_hsa046620.77952178
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76604065
91FoxO signaling pathway_Homo sapiens_hsa040680.76436876
92Colorectal cancer_Homo sapiens_hsa052100.76162582
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.73821769
94Amoebiasis_Homo sapiens_hsa051460.73769935
95TGF-beta signaling pathway_Homo sapiens_hsa043500.73726504
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.72531677
97Fanconi anemia pathway_Homo sapiens_hsa034600.72409141
98Glioma_Homo sapiens_hsa052140.71970126
99Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71958465
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.71636312
101Long-term potentiation_Homo sapiens_hsa047200.71321191
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71240062
103Olfactory transduction_Homo sapiens_hsa047400.71130945
104Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70974419
105Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70516451
106Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70511941
107Butanoate metabolism_Homo sapiens_hsa006500.70303918
108Cholinergic synapse_Homo sapiens_hsa047250.69189968
109Salivary secretion_Homo sapiens_hsa049700.68973721
110Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68827381
111T cell receptor signaling pathway_Homo sapiens_hsa046600.68096289
112Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67719405
113Pertussis_Homo sapiens_hsa051330.67006688
114Lysosome_Homo sapiens_hsa041420.66450925
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.66159937
116Lysine degradation_Homo sapiens_hsa003100.65216434
117Caffeine metabolism_Homo sapiens_hsa002320.63584954
118RNA polymerase_Homo sapiens_hsa030200.63484799
119Shigellosis_Homo sapiens_hsa051310.63158934
120Oxytocin signaling pathway_Homo sapiens_hsa049210.62729057
121Glutamatergic synapse_Homo sapiens_hsa047240.62647475
122Allograft rejection_Homo sapiens_hsa053300.62522557
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.62363380
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62316675
125Proteasome_Homo sapiens_hsa030500.62050745
126Graft-versus-host disease_Homo sapiens_hsa053320.62025738
127Fatty acid biosynthesis_Homo sapiens_hsa000610.60525153
128Proteoglycans in cancer_Homo sapiens_hsa052050.60243672
129Phenylalanine metabolism_Homo sapiens_hsa003600.59502632
130Chronic myeloid leukemia_Homo sapiens_hsa052200.59340223
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.59314623
132GnRH signaling pathway_Homo sapiens_hsa049120.58924339
133Synaptic vesicle cycle_Homo sapiens_hsa047210.58705339
134Insulin signaling pathway_Homo sapiens_hsa049100.58345952
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58012972
136Propanoate metabolism_Homo sapiens_hsa006400.57746130
137Measles_Homo sapiens_hsa051620.57634618
138Focal adhesion_Homo sapiens_hsa045100.57402591
139Salmonella infection_Homo sapiens_hsa051320.57105095
140Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.55738102
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.55526262
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55485216
143Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55404871
144Malaria_Homo sapiens_hsa051440.55313614
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54602562
146Prion diseases_Homo sapiens_hsa050200.54422874
147African trypanosomiasis_Homo sapiens_hsa051430.53472110
148Endometrial cancer_Homo sapiens_hsa052130.53178526
149cAMP signaling pathway_Homo sapiens_hsa040240.53042108
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52511122
151HIF-1 signaling pathway_Homo sapiens_hsa040660.52246348
152VEGF signaling pathway_Homo sapiens_hsa043700.52168424
153Intestinal immune network for IgA production_Homo sapiens_hsa046720.52131505
154Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.51872445
155Systemic lupus erythematosus_Homo sapiens_hsa053220.51871443
156Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.51452847
157Morphine addiction_Homo sapiens_hsa050320.50653396
158Rheumatoid arthritis_Homo sapiens_hsa053230.50643245
159Acute myeloid leukemia_Homo sapiens_hsa052210.50541630
160Insulin secretion_Homo sapiens_hsa049110.50476736
161Wnt signaling pathway_Homo sapiens_hsa043100.49765079
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48963027
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48628110
164GABAergic synapse_Homo sapiens_hsa047270.48033255
165Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47948505
166mTOR signaling pathway_Homo sapiens_hsa041500.47624036
167Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47506823
168MAPK signaling pathway_Homo sapiens_hsa040100.47166934
169Estrogen signaling pathway_Homo sapiens_hsa049150.47111907

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »