MFN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a mediator of mitochondrial fusion. This protein and mitofusin 2 are homologs of the Drosophila protein fuzzy onion (Fzo). They are mitochondrial membrane proteins that interact with each other to facilitate mitochondrial targeting. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to lipoprotein particle (GO:0055094)8.32106643
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.18663786
3branching involved in labyrinthine layer morphogenesis (GO:0060670)6.06198001
4spindle assembly involved in mitosis (GO:0090307)5.76932491
5sarcomere organization (GO:0045214)5.69907854
6regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.49254150
7negative regulation of potassium ion transmembrane transport (GO:1901380)5.38608661
8cardiac myofibril assembly (GO:0055003)5.37721121
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.37543355
10positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.20204144
11carnitine shuttle (GO:0006853)5.13452083
12myofibril assembly (GO:0030239)5.11207452
13prostate gland growth (GO:0060736)5.07328332
14tricarboxylic acid cycle (GO:0006099)5.03114242
15regulation of actin filament-based movement (GO:1903115)4.91133822
16regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.85973853
17microtubule cytoskeleton organization involved in mitosis (GO:1902850)4.82481502
18muscle filament sliding (GO:0030049)4.80623876
19actin-myosin filament sliding (GO:0033275)4.80623876
20nuclear pore organization (GO:0006999)4.79740662
21regulation of skeletal muscle contraction (GO:0014819)4.79094512
22cardiac muscle contraction (GO:0060048)4.73164478
23fatty acid transmembrane transport (GO:1902001)4.66325979
24regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.64792406
25response to caffeine (GO:0031000)4.63255224
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.60828604
27centrosome duplication (GO:0051298)4.59306208
28sarcoplasmic reticulum calcium ion transport (GO:0070296)4.58631058
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.51414405
30ventricular cardiac muscle cell action potential (GO:0086005)4.47378532
31plasma membrane repair (GO:0001778)4.38528292
32regulation of relaxation of muscle (GO:1901077)4.37826042
33nuclear pore complex assembly (GO:0051292)4.33717717
34cell communication involved in cardiac conduction (GO:0086065)4.23443546
35cardiac muscle cell development (GO:0055013)4.22041782
36snRNA transcription (GO:0009301)4.20425886
37interkinetic nuclear migration (GO:0022027)4.17453070
38regulation of acyl-CoA biosynthetic process (GO:0050812)4.15820093
39carnitine transmembrane transport (GO:1902603)4.15376048
40cell communication by electrical coupling (GO:0010644)4.11948636
41aspartate family amino acid catabolic process (GO:0009068)4.10803830
42creatine metabolic process (GO:0006600)4.10478123
43oocyte development (GO:0048599)4.09578624
44regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.09550350
45actin-mediated cell contraction (GO:0070252)4.07616119
46regulation of cell communication by electrical coupling (GO:0010649)4.06717007
47positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.05108064
48positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.05108064
49positive regulation of mitotic sister chromatid separation (GO:1901970)4.05108064
502-oxoglutarate metabolic process (GO:0006103)4.04116167
51cardiac muscle hypertrophy (GO:0003300)4.02148136
52bundle of His cell to Purkinje myocyte communication (GO:0086069)3.99561741
53striated muscle contraction (GO:0006941)3.98629420
54regulation of membrane repolarization (GO:0060306)3.98381984
55amino-acid betaine transport (GO:0015838)3.98027525
56carnitine transport (GO:0015879)3.98027525
57cardiac cell development (GO:0055006)3.91660868
58lysine catabolic process (GO:0006554)3.91129927
59lysine metabolic process (GO:0006553)3.91129927
60positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.90990012
61regulation of cardiac muscle cell contraction (GO:0086004)3.90806155
62striated muscle hypertrophy (GO:0014897)3.90123913
63inner cell mass cell proliferation (GO:0001833)3.81686418
64actomyosin structure organization (GO:0031032)3.79312610
65adult heart development (GO:0007512)3.77080271
66negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.76079248
67cytoplasmic mRNA processing body assembly (GO:0033962)3.73589309
68white fat cell differentiation (GO:0050872)3.73039759
69regulation of hippo signaling (GO:0035330)3.69196656
70regulation of striated muscle contraction (GO:0006942)3.68787695
71regulation of coenzyme metabolic process (GO:0051196)3.65766644
72regulation of cofactor metabolic process (GO:0051193)3.65766644
73regulation of sarcomere organization (GO:0060297)3.58773554
74fatty acid beta-oxidation (GO:0006635)3.58695782
75positive regulation of oligodendrocyte differentiation (GO:0048714)3.57228095
76protein K11-linked deubiquitination (GO:0035871)3.57038657
77response to UV-C (GO:0010225)3.56092504
78response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.55377896
79NADH metabolic process (GO:0006734)3.52948749
80cardiac muscle cell action potential (GO:0086001)3.51090316
81negative regulation of telomerase activity (GO:0051974)3.50757275
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48567550
83negative regulation of acute inflammatory response (GO:0002674)3.48566736
84regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.48338459
85synapsis (GO:0007129)3.47619401
86cardiac muscle cell action potential involved in contraction (GO:0086002)3.45220224
87negative regulation of protein localization to cell surface (GO:2000009)3.44174391
88relaxation of cardiac muscle (GO:0055119)3.39511781
89cardiac muscle tissue morphogenesis (GO:0055008)3.37266075
90branched-chain amino acid catabolic process (GO:0009083)3.34895378
91regulation of sequestering of triglyceride (GO:0010889)3.34753669
92muscle hypertrophy (GO:0014896)3.32637306
93regulation of sulfur metabolic process (GO:0042762)3.31127813
94biotin metabolic process (GO:0006768)3.30866009
95T cell lineage commitment (GO:0002360)3.30692692
96glycogen catabolic process (GO:0005980)3.29427554
97mitotic sister chromatid cohesion (GO:0007064)3.29040169
98short-chain fatty acid metabolic process (GO:0046459)3.25224981
99regulation of cardiac muscle contraction (GO:0055117)3.25205347
100regulation of the force of heart contraction (GO:0002026)3.24990091
101acetyl-CoA metabolic process (GO:0006084)3.24852767
102keratinocyte development (GO:0003334)3.24152273
103regulation of retinoic acid receptor signaling pathway (GO:0048385)3.23658361
104heart trabecula formation (GO:0060347)3.23474407
105potassium ion import (GO:0010107)3.22923103
106iron ion import (GO:0097286)3.20906267
107regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.19535618
108cellular ketone body metabolic process (GO:0046950)3.18837792
109cellular response to lithium ion (GO:0071285)3.18580663
110positive regulation of fatty acid oxidation (GO:0046321)3.18265529
111peripheral nervous system axon ensheathment (GO:0032292)3.15587357
112myelination in peripheral nervous system (GO:0022011)3.15587357
113cell adhesion mediated by integrin (GO:0033627)3.15311592
114anterior/posterior axis specification, embryo (GO:0008595)3.14793768
115regulation of cholesterol storage (GO:0010885)3.13418772
116carnitine metabolic process (GO:0009437)3.12286016
117quaternary ammonium group transport (GO:0015697)3.11519742
118regulation of fatty acid oxidation (GO:0046320)3.10235274
119glucan catabolic process (GO:0009251)3.09876405
120negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.09509969
121actin filament-based movement (GO:0030048)3.09317237
122fatty acid catabolic process (GO:0009062)3.09070425
123positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07898446
124muscle tissue morphogenesis (GO:0060415)3.07726183
125fatty acid oxidation (GO:0019395)3.07381787
126lipid oxidation (GO:0034440)3.05676032
127cardiac muscle hypertrophy in response to stress (GO:0014898)3.05601981
128muscle hypertrophy in response to stress (GO:0003299)3.05601981
129cardiac muscle adaptation (GO:0014887)3.05601981
130positive regulation of chromosome segregation (GO:0051984)3.04800614
131ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.01666251
132pore complex assembly (GO:0046931)3.01559470
133skeletal muscle contraction (GO:0003009)3.00185913
134gland morphogenesis (GO:0022612)2.98977661
135amino-acid betaine metabolic process (GO:0006577)2.95709152
136succinate metabolic process (GO:0006105)2.94685781
137regulation of heart rate (GO:0002027)2.94002503
138branched-chain amino acid metabolic process (GO:0009081)2.92503197
139dicarboxylic acid biosynthetic process (GO:0043650)2.92104620
140regulation of transforming growth factor beta2 production (GO:0032909)2.91127741
141CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.90862898
142positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87258216
143UDP-N-acetylglucosamine metabolic process (GO:0006047)2.87026939
144RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.86720933
145monoubiquitinated protein deubiquitination (GO:0035520)2.86175755
146cellular polysaccharide catabolic process (GO:0044247)2.85664831
147negative regulation of cytosolic calcium ion concentration (GO:0051481)2.85437975
148cardiac conduction (GO:0061337)2.84794909
149glycerol ether metabolic process (GO:0006662)2.83845574
150regulation of tight junction assembly (GO:2000810)2.82855550
151regulation of calcium ion transmembrane transport (GO:1903169)2.81894561
152regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81894561
153germinal center formation (GO:0002467)2.80929928
154magnesium ion transport (GO:0015693)2.80065795
155nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.78390194
156cell differentiation involved in embryonic placenta development (GO:0060706)2.75906893
157replicative senescence (GO:0090399)2.75029357
158intestinal epithelial cell development (GO:0060576)2.74512576
159regulation of DNA endoreduplication (GO:0032875)2.73096263
160ectoderm development (GO:0007398)2.71426559
161organ formation (GO:0048645)2.70957694
162regulation of DNA methylation (GO:0044030)2.69051896
163regulation of histone H3-K9 methylation (GO:0051570)2.68135637
164protein K48-linked deubiquitination (GO:0071108)2.66954279
165positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66627293
166negative regulation of TOR signaling (GO:0032007)2.65408265
167positive regulation of cAMP-mediated signaling (GO:0043950)2.63211635
168striated muscle atrophy (GO:0014891)2.63114712
169protein K6-linked ubiquitination (GO:0085020)2.62713025
170monocyte differentiation (GO:0030224)2.61752635
171negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.59263386
172negative regulation of mast cell activation (GO:0033004)2.59005600
173ether metabolic process (GO:0018904)2.58052204
174gene silencing by RNA (GO:0031047)2.57641509
175lateral sprouting from an epithelium (GO:0060601)2.56824955
176sister chromatid cohesion (GO:0007062)2.56712266
177regulation of energy homeostasis (GO:2000505)2.56205836
178nucleotide transmembrane transport (GO:1901679)2.52142608
179regulation of RNA export from nucleus (GO:0046831)2.51048167
180vesicle transport along microtubule (GO:0047496)2.49778903
181protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.49485330
182mitochondrion morphogenesis (GO:0070584)2.49073586
183mRNA modification (GO:0016556)2.47445106
184protein localization to microtubule cytoskeleton (GO:0072698)2.47105760
185embryonic epithelial tube formation (GO:0001838)2.46424728
186regulation of receptor binding (GO:1900120)2.45473690
187phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.44753806
188negative regulation of keratinocyte proliferation (GO:0010839)2.44613125
189lymphangiogenesis (GO:0001946)2.44020406
190microtubule anchoring (GO:0034453)2.44009273
191regulation of cell proliferation involved in kidney development (GO:1901722)2.42698035
192negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.42585045
193labyrinthine layer development (GO:0060711)2.42230380
194lipoprotein transport (GO:0042953)2.42145936
195positive regulation of glomerulus development (GO:0090193)2.41993519
196wound healing, spreading of epidermal cells (GO:0035313)2.41800821

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.30024372
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.89402092
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.59225670
4ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46141844
5SALL1_21062744_ChIP-ChIP_HESCs_Human3.15722339
6CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.11691122
7EZH2_22144423_ChIP-Seq_EOC_Human2.95604929
8EP300_21415370_ChIP-Seq_HL-1_Mouse2.83824997
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.71065037
10* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.55293889
11RXR_22158963_ChIP-Seq_LIVER_Mouse2.39319449
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30499628
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.25622610
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.20164786
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.19972499
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13082938
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.07026371
18ZFP57_27257070_Chip-Seq_ESCs_Mouse2.04909958
19ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.04762062
20E2F7_22180533_ChIP-Seq_HELA_Human2.01658890
21FUS_26573619_Chip-Seq_HEK293_Human2.01497207
22ESR1_20079471_ChIP-ChIP_T-47D_Human2.00141959
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.99991746
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.99991746
25KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97116853
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.93230916
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.90240781
28FOXM1_26456572_ChIP-Seq_MCF-7_Human1.82490502
29RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.78717035
30ZNF263_19887448_ChIP-Seq_K562_Human1.73231744
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.69998375
32IGF1R_20145208_ChIP-Seq_DFB_Human1.63071944
33NANOG_18555785_Chip-Seq_ESCs_Mouse1.62801920
34ER_23166858_ChIP-Seq_MCF-7_Human1.62038568
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.59828470
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58863517
37PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57928697
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.57014150
39DROSHA_22980978_ChIP-Seq_HELA_Human1.56348578
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.56269954
41CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.56069637
42SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46133610
43MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.45229314
44TP53_18474530_ChIP-ChIP_U2OS_Human1.42435020
45AR_21572438_ChIP-Seq_LNCaP_Human1.41784076
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.39638465
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39088252
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38882994
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38882994
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.38424985
51NFE2_27457419_Chip-Seq_LIVER_Mouse1.38314215
52GBX2_23144817_ChIP-Seq_PC3_Human1.37567324
53FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.35405020
54CMYC_18555785_Chip-Seq_ESCs_Mouse1.34943701
55E2F1_18555785_Chip-Seq_ESCs_Mouse1.34303160
56FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34303106
57IRF1_19129219_ChIP-ChIP_H3396_Human1.33915455
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33375917
59SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.32517551
60SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32194860
61ZNF274_21170338_ChIP-Seq_K562_Hela1.32147320
62EWS_26573619_Chip-Seq_HEK293_Human1.31883897
63CDX2_22108803_ChIP-Seq_LS180_Human1.31848433
64TAF15_26573619_Chip-Seq_HEK293_Human1.31434349
65EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31148337
66FOXA2_19822575_ChIP-Seq_HepG2_Human1.30712056
67GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29356412
68P300_19829295_ChIP-Seq_ESCs_Human1.28357104
69MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.27692006
70BRD4_25478319_ChIP-Seq_HGPS_Human1.27515389
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.26989101
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26556877
73FOXO3_23340844_ChIP-Seq_DLD1_Human1.26380385
74GATA1_22025678_ChIP-Seq_K562_Human1.25099982
75E2F4_17652178_ChIP-ChIP_JURKAT_Human1.24912893
76OCT4_18555785_Chip-Seq_ESCs_Mouse1.23803388
77PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23345568
78P53_22387025_ChIP-Seq_ESCs_Mouse1.22696204
79* P300_18555785_Chip-Seq_ESCs_Mouse1.22367588
80CJUN_26792858_Chip-Seq_BT549_Human1.21702377
81SUZ12_18555785_Chip-Seq_ESCs_Mouse1.21698274
82SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.20442029
83SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.19790448
84SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.19790448
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19318522
86EZH2_27294783_Chip-Seq_ESCs_Mouse1.16730828
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16517378
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.15021299
89TP63_23658742_ChIP-Seq_EP156T_Human1.14053566
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.13187400
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.13087369
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13071514
93JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12648547
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12064222
95AR_25329375_ChIP-Seq_VCAP_Human1.11698007
96NMYC_18555785_Chip-Seq_ESCs_Mouse1.11184822
97FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.10550607
98PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.09904825
99PIAS1_25552417_ChIP-Seq_VCAP_Human1.09715529
100* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.09612748
101Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09562923
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.09066879
103SMAD3_21741376_ChIP-Seq_HESCs_Human1.08399464
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.07930427
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07891013
106BCAT_22108803_ChIP-Seq_LS180_Human1.07275560
107STAT6_21828071_ChIP-Seq_BEAS2B_Human1.06463546
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06291695
109TOP2B_26459242_ChIP-Seq_MCF-7_Human1.06118625
110TP63_19390658_ChIP-ChIP_HaCaT_Human1.05940823
111CBP_20019798_ChIP-Seq_JUKART_Human1.03061206
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.03061206
113CTNNB1_20460455_ChIP-Seq_HCT116_Human1.02737760
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.02637792
115ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.00899414
116TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00531204
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.00336821
118AR_21909140_ChIP-Seq_LNCAP_Human1.00196942
119SMAD4_21741376_ChIP-Seq_HESCs_Human0.99949118
120FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98869877
121PPAR_26484153_Chip-Seq_NCI-H1993_Human0.98466872
122SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.98442672
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98279400
124SMAD4_21799915_ChIP-Seq_A2780_Human0.96929664
125RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96027481
126AUTS2_25519132_ChIP-Seq_293T-REX_Human0.95330962
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94726020
128EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94572264
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.94255592
130JARID2_20075857_ChIP-Seq_MESCs_Mouse0.94128646
131TBL1_22424771_ChIP-Seq_293T_Human0.93977517
132WT1_25993318_ChIP-Seq_PODOCYTE_Human0.93793176
133AHR_22903824_ChIP-Seq_MCF-7_Human0.93380521
134GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92680667
135SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.92292832
136THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91959261
137EGR1_23403033_ChIP-Seq_LIVER_Mouse0.91330487
138CTCF_27219007_Chip-Seq_Bcells_Human0.90416375
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89906836
140AR_19668381_ChIP-Seq_PC3_Human0.89439579
141HTT_18923047_ChIP-ChIP_STHdh_Human0.89124303
142SUZ12_27294783_Chip-Seq_ESCs_Mouse0.88167338
143STAT3_23295773_ChIP-Seq_U87_Human0.87978134
144* ISL1_27105846_Chip-Seq_CPCs_Mouse0.87848549
145SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.87784495
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.87254619
147ERG_21242973_ChIP-ChIP_JURKAT_Human0.86437313
148AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86044830
149SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.84626558
150TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84379158
151ESR1_21235772_ChIP-Seq_MCF-7_Human0.84366536
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.82457390
153PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.82243732
154ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81757569
155ARNT_22903824_ChIP-Seq_MCF-7_Human0.81724522
156NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.81660054
157MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81268786
158TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.80647110
159KLF4_19829295_ChIP-Seq_ESCs_Human0.79747786
160TP53_16413492_ChIP-PET_HCT116_Human0.79429750
161ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78111754
162UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.78076156
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.77660891
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.77124069
165TCF4_23295773_ChIP-Seq_U87_Human0.76077455
166NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75218766
167NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75218766
168CBP_21632823_ChIP-Seq_H3396_Human0.74832988

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.28470575
2MP0010234_abnormal_vibrissa_follicle5.04844662
3MP0002837_dystrophic_cardiac_calcinosis4.86856536
4MP0000751_myopathy4.58842080
5MP0004084_abnormal_cardiac_muscle4.21520962
6MP0004215_abnormal_myocardial_fiber4.14106794
7MP0000013_abnormal_adipose_tissue4.06237564
8MP0008057_abnormal_DNA_replication3.76523646
9MP0004036_abnormal_muscle_relaxation3.51255891
10MP0000749_muscle_degeneration3.47122690
11MP0010678_abnormal_skin_adnexa3.35887853
12MP0005330_cardiomyopathy3.26813035
13MP0004145_abnormal_muscle_electrophysio3.07173751
14MP0004130_abnormal_muscle_cell2.91185253
15MP0000383_abnormal_hair_follicle2.83811950
16MP0003693_abnormal_embryo_hatching2.78162134
17MP0003137_abnormal_impulse_conducting2.75059373
18MP0004087_abnormal_muscle_fiber2.73207024
19MP0002138_abnormal_hepatobiliary_system2.68713477
20MP0010352_gastrointestinal_tract_polyps2.58189222
21MP0002972_abnormal_cardiac_muscle2.42382020
22MP0005620_abnormal_muscle_contractility2.42255485
23MP0000747_muscle_weakness2.41569273
24MP0000537_abnormal_urethra_morphology2.37343774
25MP0000427_abnormal_hair_cycle2.37242920
26MP0002269_muscular_atrophy2.36447338
27MP0008775_abnormal_heart_ventricle2.36037556
28MP0002106_abnormal_muscle_physiology2.32622606
29MP0004484_altered_response_of2.27616343
30MP0000750_abnormal_muscle_regeneration2.24255655
31MP0005367_renal/urinary_system_phenotyp2.23068185
32MP0000516_abnormal_urinary_system2.23068185
33MP0003724_increased_susceptibility_to2.17382900
34MP0005076_abnormal_cell_differentiation2.08537976
35MP0010630_abnormal_cardiac_muscle2.02679899
36MP0005385_cardiovascular_system_phenoty1.97582239
37MP0001544_abnormal_cardiovascular_syste1.97582239
38MP0006138_congestive_heart_failure1.93916967
39MP0005369_muscle_phenotype1.93878957
40MP0002139_abnormal_hepatobiliary_system1.88440543
41MP0005085_abnormal_gallbladder_physiolo1.85818956
42MP0004085_abnormal_heartbeat1.82115938
43MP0000759_abnormal_skeletal_muscle1.81788052
44MP0002009_preneoplasia1.78485663
45MP0000569_abnormal_digit_pigmentation1.77447541
46MP0002160_abnormal_reproductive_system1.72642409
47MP0003890_abnormal_embryonic-extraembry1.71210587
48MP0003950_abnormal_plasma_membrane1.70616567
49MP0003718_maternal_effect1.70399693
50MP0004233_abnormal_muscle_weight1.66319148
51MP0009053_abnormal_anal_canal1.64771025
52MP0005646_abnormal_pituitary_gland1.63685916
53MP0005666_abnormal_adipose_tissue1.58850537
54MP0003315_abnormal_perineum_morphology1.55839288
55MP0005360_urolithiasis1.55748305
56MP0003221_abnormal_cardiomyocyte_apopto1.54460327
57* MP0006036_abnormal_mitochondrial_physio1.51988487
58MP0010094_abnormal_chromosome_stability1.51768880
59MP0005310_abnormal_salivary_gland1.51417904
60MP0002332_abnormal_exercise_endurance1.43616956
61MP0004043_abnormal_pH_regulation1.42425164
62MP0003806_abnormal_nucleotide_metabolis1.41781843
63MP0003937_abnormal_limbs/digits/tail_de1.37771828
64MP0003183_abnormal_peptide_metabolism1.37607784
65MP0005670_abnormal_white_adipose1.36343559
66MP0005365_abnormal_bile_salt1.34592173
67MP0002127_abnormal_cardiovascular_syste1.34257715
68MP0000377_abnormal_hair_follicle1.33301334
69MP0004957_abnormal_blastocyst_morpholog1.30336175
70MP0002166_altered_tumor_susceptibility1.28772893
71MP0001727_abnormal_embryo_implantation1.28495053
72MP0005332_abnormal_amino_acid1.26732620
73MP0003828_pulmonary_edema1.26716323
74MP0003119_abnormal_digestive_system1.25528908
75MP0000627_abnormal_mammary_gland1.23956216
76MP0009840_abnormal_foam_cell1.23588391
77MP0005389_reproductive_system_phenotype1.21103538
78MP0002006_tumorigenesis1.20586659
79MP0005451_abnormal_body_composition1.19756936
80MP0010307_abnormal_tumor_latency1.15552349
81MP0003936_abnormal_reproductive_system1.13084879
82MP0000467_abnormal_esophagus_morphology1.12807894
83MP0002060_abnormal_skin_morphology1.11645588
84MP0001849_ear_inflammation1.11277251
85MP0000613_abnormal_salivary_gland1.11132440
86MP0003195_calcinosis1.09425669
87* MP0001697_abnormal_embryo_size1.05801866
88MP0004381_abnormal_hair_follicle1.03936226
89MP0002108_abnormal_muscle_morphology1.03809076
90MP0004185_abnormal_adipocyte_glucose1.03692479
91MP0005395_other_phenotype1.01855518
92MP0003045_fibrosis1.01695835
93MP0006054_spinal_hemorrhage1.00968558
94MP0005375_adipose_tissue_phenotype0.98713212
95MP0002282_abnormal_trachea_morphology0.98699087
96MP0008875_abnormal_xenobiotic_pharmacok0.98524292
97MP0000647_abnormal_sebaceous_gland0.96287080
98MP0003252_abnormal_bile_duct0.96260022
99MP0005220_abnormal_exocrine_pancreas0.96245213
100MP0005379_endocrine/exocrine_gland_phen0.96045538
101MP0000428_abnormal_craniofacial_morphol0.95352299
102MP0002971_abnormal_brown_adipose0.94820274
103MP0002086_abnormal_extraembryonic_tissu0.93915229
104MP0002118_abnormal_lipid_homeostasis0.91795460
105* MP0006035_abnormal_mitochondrial_morpho0.91779007
106MP0004270_analgesia0.91483267
107MP0003941_abnormal_skin_development0.91310389
108MP0003690_abnormal_glial_cell0.90617352
109MP0000579_abnormal_nail_morphology0.90319697
110MP0004510_myositis0.89123062
111MP0003567_abnormal_fetal_cardiomyocyte0.88596530
112MP0005248_abnormal_Harderian_gland0.86983760
113MP0009046_muscle_twitch0.86645817
114MP0002163_abnormal_gland_morphology0.86121527
115MP0004197_abnormal_fetal_growth/weight/0.84452234
116MP0010329_abnormal_lipoprotein_level0.83971874
117MP0002234_abnormal_pharynx_morphology0.83875353
118MP0005165_increased_susceptibility_to0.83714534
119MP0005266_abnormal_metabolism0.83547090
120MP0000015_abnormal_ear_pigmentation0.82568571
121MP0004885_abnormal_endolymph0.81069272
122MP0004147_increased_porphyrin_level0.80859584
123MP0003077_abnormal_cell_cycle0.80257431
124MP0002751_abnormal_autonomic_nervous0.79694055
125MP0002098_abnormal_vibrissa_morphology0.78262698
126MP0000266_abnormal_heart_morphology0.77038516
127MP0002876_abnormal_thyroid_physiology0.76257848
128MP0000230_abnormal_systemic_arterial0.75290376
129MP0002102_abnormal_ear_morphology0.75123834
130MP0001216_abnormal_epidermal_layer0.73472634
131MP0002177_abnormal_outer_ear0.73298616
132MP0005275_abnormal_skin_tensile0.72030101
133MP0005647_abnormal_sex_gland0.70943391
134MP0000049_abnormal_middle_ear0.70835724
135MP0002084_abnormal_developmental_patter0.70819239
136MP0003566_abnormal_cell_adhesion0.70441563
137MP0008789_abnormal_olfactory_epithelium0.69872481
138* MP0002088_abnormal_embryonic_growth/wei0.69733968
139MP0002254_reproductive_system_inflammat0.69318345
140MP0005319_abnormal_enzyme/_coenzyme0.68872636
141MP0009765_abnormal_xenobiotic_induced0.68711679
142MP0004134_abnormal_chest_morphology0.68174218
143MP0004859_abnormal_synaptic_plasticity0.68063241
144* MP0003984_embryonic_growth_retardation0.67999986
145MP0010771_integument_phenotype0.67018402
146MP0003329_amyloid_beta_deposits0.66911948
147MP0005083_abnormal_biliary_tract0.64849080
148MP0002168_other_aberrant_phenotype0.64717144
149MP0005584_abnormal_enzyme/coenzyme_acti0.64364007
150MP0008877_abnormal_DNA_methylation0.63428390
151MP0008569_lethality_at_weaning0.63100054
152MP0002796_impaired_skin_barrier0.62330344
153MP0001919_abnormal_reproductive_system0.62221400
154* MP0001672_abnormal_embryogenesis/_devel0.61832635
155* MP0005380_embryogenesis_phenotype0.61832635
156MP0005423_abnormal_somatic_nervous0.61683367
157MP0005535_abnormal_body_temperature0.61523982
158MP0001486_abnormal_startle_reflex0.60997184
159MP0004924_abnormal_behavior0.59652447
160MP0005386_behavior/neurological_phenoty0.59652447
161MP0002078_abnormal_glucose_homeostasis0.59267167
162MP0003136_yellow_coat_color0.58930073
163MP0001440_abnormal_grooming_behavior0.57726440
164MP0005187_abnormal_penis_morphology0.57565528
165MP0000920_abnormal_myelination0.57504081
166MP0005623_abnormal_meninges_morphology0.56479119
167MP0000733_abnormal_muscle_development0.56084201
168MP0002272_abnormal_nervous_system0.56071182
169MP0004142_abnormal_muscle_tone0.55382105
170MP0000003_abnormal_adipose_tissue0.54333394
171MP0002067_abnormal_sensory_capabilities0.53732063
172MP0002909_abnormal_adrenal_gland0.52385348
173MP0001661_extended_life_span0.51971788
174MP0001485_abnormal_pinna_reflex0.50694184
175MP0003635_abnormal_synaptic_transmissio0.48846255
176MP0005377_hearing/vestibular/ear_phenot0.48754950
177MP0003878_abnormal_ear_physiology0.48754950
178MP0003656_abnormal_erythrocyte_physiolo0.47374091
179MP0009780_abnormal_chondrocyte_physiolo0.47305485
180MP0002128_abnormal_blood_circulation0.46230727
181MP0002822_catalepsy0.46134228

Predicted human phenotypes

RankGene SetZ-score
1Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)7.48687395
2Short 1st metacarpal (HP:0010034)7.48687395
3Abnormality of the 1st metacarpal (HP:0010009)6.48822121
4Sudden death (HP:0001699)6.19643754
5Exercise-induced myalgia (HP:0003738)5.99684560
6Exercise-induced muscle cramps (HP:0003710)5.47248513
7Stenosis of the external auditory canal (HP:0000402)5.41720388
8Calf muscle hypertrophy (HP:0008981)5.37164640
9Muscle fiber splitting (HP:0003555)5.23575113
10Muscle hypertrophy of the lower extremities (HP:0008968)5.20711673
11Ventricular tachycardia (HP:0004756)5.02666597
12Myoglobinuria (HP:0002913)4.79887191
13Atrial fibrillation (HP:0005110)4.73648158
14Hyporeflexia of lower limbs (HP:0002600)4.51760340
15Bundle branch block (HP:0011710)4.45271332
16Abnormality of the calf musculature (HP:0001430)4.37828588
17Primary atrial arrhythmia (HP:0001692)4.37237665
18Short phalanx of the thumb (HP:0009660)4.36591063
19Ectopic kidney (HP:0000086)4.30290631
20Syncope (HP:0001279)4.25182289
21Fused cervical vertebrae (HP:0002949)4.19649535
22Supraventricular tachycardia (HP:0004755)4.15964348
23Supraventricular arrhythmia (HP:0005115)4.05799730
24Right ventricular cardiomyopathy (HP:0011663)3.93445935
25Atrioventricular block (HP:0001678)3.86739381
26Heart block (HP:0012722)3.83154495
27Difficulty running (HP:0009046)3.80011087
28Lipoatrophy (HP:0100578)3.75338389
29Carpal bone hypoplasia (HP:0001498)3.75296275
30Subaortic stenosis (HP:0001682)3.70733706
31Abnormality of the left ventricular outflow tract (HP:0011103)3.70733706
32Oligomenorrhea (HP:0000876)3.67486326
33Chromosomal breakage induced by crosslinking agents (HP:0003221)3.61777091
34EMG: myopathic abnormalities (HP:0003458)3.57153889
35Ventricular arrhythmia (HP:0004308)3.56837449
36Abnormal atrioventricular conduction (HP:0005150)3.55772428
37Rhabdomyolysis (HP:0003201)3.55572081
38Chromsome breakage (HP:0040012)3.50861093
39Prolonged QT interval (HP:0001657)3.47106200
40Hyperglycinuria (HP:0003108)3.46919686
41Dilated cardiomyopathy (HP:0001644)3.43844914
42Hematochezia (HP:0002573)3.43703073
43Short humerus (HP:0005792)3.39806298
44Muscle fiber inclusion bodies (HP:0100299)3.34330871
45Palpitations (HP:0001962)3.34231094
46Ventricular fibrillation (HP:0001663)3.34122068
47Abnormality of the nasal septum (HP:0000419)3.28308385
48Ketoacidosis (HP:0001993)3.27151436
49Short hallux (HP:0010109)3.24428138
50Aplasia/Hypoplasia involving the musculature (HP:0001460)3.22688369
51Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.21550337
52Abnormality of the proximal phalanges of the hand (HP:0009834)3.18606078
53Increased connective tissue (HP:0009025)3.18231763
54Toxemia of pregnancy (HP:0100603)3.13826302
55Reduced subcutaneous adipose tissue (HP:0003758)3.12131386
56Aplasia/hypoplasia of the humerus (HP:0006507)3.11747082
57Insulin-resistant diabetes mellitus (HP:0000831)3.11061446
58Abnormality of the renal collecting system (HP:0004742)3.10566557
59Abnormality of glycine metabolism (HP:0010895)3.06544910
60Abnormality of serine family amino acid metabolism (HP:0010894)3.06544910
61Myotonia (HP:0002486)3.01551730
62Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.99982273
63Hypoglycemic coma (HP:0001325)2.97104225
64Aplasia/Hypoplasia of the hallux (HP:0008362)2.96792862
65Rectovaginal fistula (HP:0000143)2.95008663
66Rectal fistula (HP:0100590)2.95008663
67Abnormality of fatty-acid metabolism (HP:0004359)2.86987443
68Ketosis (HP:0001946)2.84829260
69Asymmetric septal hypertrophy (HP:0001670)2.83434815
70Muscle stiffness (HP:0003552)2.81618993
71Hyperammonemia (HP:0001987)2.76293550
72Duplicated collecting system (HP:0000081)2.75705219
73Hyperglycinemia (HP:0002154)2.74620736
74Hypoalphalipoproteinemia (HP:0003233)2.72927399
75Nemaline bodies (HP:0003798)2.71778189
76Dicarboxylic aciduria (HP:0003215)2.70433254
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.70433254
78Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.68868766
79Submucous cleft hard palate (HP:0000176)2.67108587
80Absent thumb (HP:0009777)2.64132120
81Curly hair (HP:0002212)2.61706644
82Absent radius (HP:0003974)2.60626857
83Abnormal EKG (HP:0003115)2.57367813
84Abnormality of DNA repair (HP:0003254)2.52467324
85Difficulty climbing stairs (HP:0003551)2.49780492
86Intestinal fistula (HP:0100819)2.48035448
87Type 1 muscle fiber predominance (HP:0003803)2.45851002
88Synostosis of carpal bones (HP:0005048)2.43707191
89Abnormality of alanine metabolism (HP:0010916)2.43112809
90Hyperalaninemia (HP:0003348)2.43112809
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.43112809
92Decreased subcutaneous fat (HP:0001002)2.42342185
93Congenital sensorineural hearing impairment (HP:0008527)2.39468955
94Vaginal fistula (HP:0004320)2.39450774
95Aplasia involving forearm bones (HP:0009822)2.39197679
96Absent forearm bone (HP:0003953)2.39197679
97Left ventricular hypertrophy (HP:0001712)2.38456830
98Increased variability in muscle fiber diameter (HP:0003557)2.38179077
99Sandal gap (HP:0001852)2.34884691
100Rimmed vacuoles (HP:0003805)2.34756643
101Abnormality of the distal phalanges of the toes (HP:0010182)2.34586757
102Absent phalangeal crease (HP:0006109)2.27890286
103Distal lower limb muscle weakness (HP:0009053)2.24931348
104Areflexia of lower limbs (HP:0002522)2.24485642
105Short thumb (HP:0009778)2.21148110
106Abnormal finger flexion creases (HP:0006143)2.18938670
107Hyperlipoproteinemia (HP:0010980)2.18719104
108Hepatic necrosis (HP:0002605)2.17890099
109Osteomalacia (HP:0002749)2.17818774
110Abnormality of the carotid arteries (HP:0005344)2.16214539
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.14555742
112Abnormality of skeletal muscle fiber size (HP:0012084)2.14187956
113Wide intermamillary distance (HP:0006610)2.13986733
114Subacute progressive viral hepatitis (HP:0006572)2.13931771
115Gout (HP:0001997)2.13829040
116Dysmetric saccades (HP:0000641)2.13151041
117Neck muscle weakness (HP:0000467)2.12119512
118Hamartoma of the eye (HP:0010568)2.11550153
119Abnormality of subcutaneous fat tissue (HP:0001001)2.10652156
120Abnormality of the parathyroid morphology (HP:0011766)2.09567642
121Chorioretinal atrophy (HP:0000533)2.09332984
122Thick nail (HP:0001805)2.08873900
123Papillary thyroid carcinoma (HP:0002895)2.08859342
124Hyperinsulinemic hypoglycemia (HP:0000825)2.08622995
125Hyperglycemia (HP:0003074)2.07643201
126Cutaneous finger syndactyly (HP:0010554)2.07025265
127Overlapping toe (HP:0001845)2.05909910
128Cerebral edema (HP:0002181)2.03848087
129Abnormality of serum amino acid levels (HP:0003112)2.03560423
130Long nose (HP:0003189)2.03156153
131Gowers sign (HP:0003391)2.01093541
132Pheochromocytoma (HP:0002666)2.01038229
133Palmoplantar keratoderma (HP:0000982)2.00928557
134Gonadotropin excess (HP:0000837)2.00648629
135Abnormality of chromosome stability (HP:0003220)1.99765177
136Gaze-evoked nystagmus (HP:0000640)1.98906653
137Anal stenosis (HP:0002025)1.98599140
138Hypoplastic ischia (HP:0003175)1.98466487
139Severe muscular hypotonia (HP:0006829)1.95993074
140Morphological abnormality of the middle ear (HP:0008609)1.95079147
141Cubitus valgus (HP:0002967)1.94744497
142Horseshoe kidney (HP:0000085)1.94221304
143Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.93241988
144Ureteral duplication (HP:0000073)1.92771910
145Metabolic acidosis (HP:0001942)1.90835444
146Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.90792338
147Increased muscle lipid content (HP:0009058)1.89627830
148Lethargy (HP:0001254)1.89513427
149Proximal tubulopathy (HP:0000114)1.89258547
150Muscular dystrophy (HP:0003560)1.88033378
151Transitional cell carcinoma of the bladder (HP:0006740)1.87810259
152Abnormal pancreas size (HP:0012094)1.87664942
153Athetosis (HP:0002305)1.87203733
154Increased purine levels (HP:0004368)1.85881290
155Hyperuricemia (HP:0002149)1.85881290
156Fair hair (HP:0002286)1.85851639
157Lip pit (HP:0100267)1.82933170
158Foot dorsiflexor weakness (HP:0009027)1.82429250
159Acute encephalopathy (HP:0006846)1.82173583
160Abnormality of the foot musculature (HP:0001436)1.81935620
161Testicular atrophy (HP:0000029)1.81096138
162Short chin (HP:0000331)1.80931454
163Bladder neoplasm (HP:0009725)1.78837951
164Bladder carcinoma (HP:0002862)1.78837951
165Hypolipoproteinemia (HP:0010981)1.78175980
166Abnormality of the ischium (HP:0003174)1.78115679
167Neoplasm of the adrenal cortex (HP:0100641)1.77784759
168EMG: neuropathic changes (HP:0003445)1.75001879
169Abnormality of the labia majora (HP:0012881)1.74619218
170Sudden cardiac death (HP:0001645)1.73079540
171Ragged-red muscle fibers (HP:0003200)1.72593999
172Xanthomatosis (HP:0000991)1.72218522
173Limb-girdle muscle atrophy (HP:0003797)1.71767967
174Intrahepatic cholestasis (HP:0001406)1.71324608
175Central scotoma (HP:0000603)1.71214696
176Cholelithiasis (HP:0001081)1.70646064
177Neuroendocrine neoplasm (HP:0100634)1.70548029
178Poikiloderma (HP:0001029)1.69817922
179Preaxial foot polydactyly (HP:0001841)1.67378537
180Tented upper lip vermilion (HP:0010804)1.66068484
181Insidious onset (HP:0003587)1.65216520
182Termporal pattern (HP:0011008)1.65216520
183Uterine leiomyosarcoma (HP:0002891)1.63912579
184Leiomyosarcoma (HP:0100243)1.63912579
185Meningioma (HP:0002858)1.63548345
186Aplasia/Hypoplasia of the uvula (HP:0010293)1.63478573
187Relative macrocephaly (HP:0004482)1.62872560
188Blepharitis (HP:0000498)1.62130185
189Astrocytoma (HP:0009592)1.62058592
190Abnormality of the astrocytes (HP:0100707)1.62058592
191Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.61568714
192Menstrual irregularities (HP:0000858)1.61294562
193Increased corneal curvature (HP:0100692)1.59651727

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.29769624
2PHKG24.31935751
3PHKG14.31935751
4OBSCN4.27143571
5TTN4.24651033
6CDK93.83719721
7PDK43.61400810
8PDK33.61400810
9PINK13.03204582
10EIF2AK32.97785652
11LMTK22.96056349
12BRSK22.58635989
13BMPR1B2.49375804
14MUSK2.39483010
15PDK22.34243593
16BCKDK2.28786718
17GRK12.24420426
18NEK12.15036742
19PLK22.00422384
20DMPK1.99168078
21ERBB31.96674279
22STK31.86418068
23MELK1.80903542
24MAP2K11.80161297
25TRIB31.75682783
26STK391.68528760
27MYLK1.67231055
28LATS11.65681712
29PIK3CA1.63472538
30WNK41.55157470
31STK381.50668690
32BMPR21.47332332
33PKN21.44870753
34PBK1.43698621
35WNK11.41635666
36TAF11.40501497
37TIE11.38120167
38STK38L1.30875832
39MKNK21.28957737
40NLK1.24428011
41PRKAA11.23310249
42CAMK2D1.22954795
43PAK31.21358201
44PRKAA21.21145629
45EEF2K1.17435262
46TRIM281.17049135
47DYRK31.16918472
48PKN11.16765070
49CASK1.16466820
50BCR1.14713412
51WNK31.14022085
52STK241.13605813
53GRK71.12963022
54TGFBR11.12873689
55MAP3K71.11899613
56BRD41.09716471
57EIF2AK11.09690904
58PRKD11.09044275
59INSRR1.06205607
60LATS21.05810426
61MAP3K131.05748026
62MAPK121.04310377
63MAP2K41.04155139
64SRPK10.98952299
65EPHA30.98909223
66CDK120.96416194
67CDK80.95917430
68ZAK0.94295881
69TTK0.93867098
70ADRBK20.93193349
71PAK60.91036530
72ICK0.90805873
73SIK10.88382006
74CAMK2G0.87688727
75RPS6KB20.86617764
76CDC70.85898687
77CSNK1A1L0.82574349
78CDC42BPA0.81947274
79SGK30.81546335
80MARK10.79960217
81OXSR10.78642782
82CAMK2A0.78371202
83ROCK10.78008740
84SGK4940.77855233
85SGK2230.77855233
86PLK10.77287021
87CSNK1G10.76343013
88NUAK10.76306297
89MST40.75836479
90PNCK0.75816487
91IRAK10.75212781
92MAP3K40.75150516
93ACVR1B0.74917277
94FGFR30.74312317
95MAP3K90.73717379
96MAP3K140.73459790
97CLK10.72147739
98RIPK10.71756806
99RPS6KB10.69477203
100BLK0.68280095
101SGK20.67182752
102YES10.66222488
103MKNK10.66051427
104TNIK0.65578326
105PRKCI0.65299354
106PDGFRA0.65027663
107PDPK10.64865878
108EPHB10.64158878
109RPS6KA40.62335153
110CAMK40.61948640
111ATM0.61783117
112CSNK1G30.61170006
113MAPK130.59547304
114PRKACB0.58989609
115CAMK1G0.58313783
116CAMKK20.57496094
117CHEK10.57356972
118AKT20.57139336
119PRKCE0.56461282
120MAP2K70.56014282
121EIF2AK20.55798228
122PRKD30.54848472
123MST1R0.53946943
124PLK30.53388596
125EPHA40.52535114
126NTRK20.52353237
127MAPKAPK50.52329646
128ROCK20.50179372
129CAMK10.50105225
130CSNK1G20.49804556
131ERBB40.49035202
132ATR0.48612689
133STK110.48169222
134PRKACA0.48095704
135SGK10.47837825
136TRPM70.46672761
137CDK60.46470590
138PRKACG0.45697361
139CAMK2B0.43115156
140ILK0.42838755
141PTK20.42636293
142JAK10.42365382
143FER0.42233669
144PDK10.41336123
145EGFR0.40474146
146RPS6KA30.39845558
147MAP4K20.39612310
148NEK90.39426132
149AKT30.39205282
150NEK60.38315847
151PIK3CG0.37852539
152KSR10.35655380
153TYRO30.35171647
154FLT30.34492107
155MAPKAPK30.33169950
156MAP3K60.33078775
157PRKG10.32963148
158PRKCH0.32595069
159MAPK110.32442678
160CHUK0.32304872
161RET0.31147661
162MAP3K50.30395859
163MTOR0.28197982
164PRKD20.27064049
165MAPK70.26563210
166CAMK1D0.25728995
167MET0.25191574
168NTRK30.24682942
169ALK0.24085822
170CSNK1D0.23178043
171CAMKK10.22746395
172PTK60.22598949
173CSNK1E0.21962074

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.85841057
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.57238384
3Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.48086398
4Propanoate metabolism_Homo sapiens_hsa006403.27162839
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19516738
6Fatty acid degradation_Homo sapiens_hsa000713.17030258
7Thyroid cancer_Homo sapiens_hsa052163.05800130
8Nitrogen metabolism_Homo sapiens_hsa009103.01286523
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.82295503
10Selenocompound metabolism_Homo sapiens_hsa004502.70226401
11Fatty acid metabolism_Homo sapiens_hsa012122.66099029
12Cardiac muscle contraction_Homo sapiens_hsa042602.45115826
13p53 signaling pathway_Homo sapiens_hsa041152.35300370
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30917524
15Butanoate metabolism_Homo sapiens_hsa006502.29392928
16Dilated cardiomyopathy_Homo sapiens_hsa054142.20379910
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.14131590
18Carbon metabolism_Homo sapiens_hsa012002.04600313
19Arginine biosynthesis_Homo sapiens_hsa002201.99548886
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.97379269
21Fanconi anemia pathway_Homo sapiens_hsa034601.90714149
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81909160
23Basal transcription factors_Homo sapiens_hsa030221.78478132
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.74855753
25Non-homologous end-joining_Homo sapiens_hsa034501.74431596
26Pyruvate metabolism_Homo sapiens_hsa006201.69973497
27RNA degradation_Homo sapiens_hsa030181.69173763
28PPAR signaling pathway_Homo sapiens_hsa033201.69059217
29Fatty acid elongation_Homo sapiens_hsa000621.69016336
30Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.60201921
31Tryptophan metabolism_Homo sapiens_hsa003801.53726698
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49555794
33Cell cycle_Homo sapiens_hsa041101.48465517
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46801267
35Fatty acid biosynthesis_Homo sapiens_hsa000611.46753012
36Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.45544690
37beta-Alanine metabolism_Homo sapiens_hsa004101.44063411
38Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.43421340
39mTOR signaling pathway_Homo sapiens_hsa041501.41036397
40Adherens junction_Homo sapiens_hsa045201.38606105
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.36545283
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.36310365
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.36008740
44TGF-beta signaling pathway_Homo sapiens_hsa043501.35941433
45Renin-angiotensin system_Homo sapiens_hsa046141.34717491
46Prostate cancer_Homo sapiens_hsa052151.31139049
47Small cell lung cancer_Homo sapiens_hsa052221.28838794
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.27588981
49RNA transport_Homo sapiens_hsa030131.26267702
50Peroxisome_Homo sapiens_hsa041461.25877881
51Vitamin B6 metabolism_Homo sapiens_hsa007501.23760238
52Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.23672523
53Biosynthesis of amino acids_Homo sapiens_hsa012301.23178010
54Starch and sucrose metabolism_Homo sapiens_hsa005001.20500404
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18774578
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17458417
57Arginine and proline metabolism_Homo sapiens_hsa003301.17315143
58MicroRNAs in cancer_Homo sapiens_hsa052061.16810860
59FoxO signaling pathway_Homo sapiens_hsa040681.14845476
60Parkinsons disease_Homo sapiens_hsa050121.12850738
61Melanoma_Homo sapiens_hsa052181.10028016
62Bile secretion_Homo sapiens_hsa049761.08936693
63Jak-STAT signaling pathway_Homo sapiens_hsa046301.08840778
64Oxidative phosphorylation_Homo sapiens_hsa001901.08351622
65Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06579761
66Maturity onset diabetes of the young_Homo sapiens_hsa049501.03697319
67Hippo signaling pathway_Homo sapiens_hsa043901.02607525
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.02539671
69Sphingolipid metabolism_Homo sapiens_hsa006000.99629410
70Oocyte meiosis_Homo sapiens_hsa041140.98864341
71Inositol phosphate metabolism_Homo sapiens_hsa005620.98841670
72mRNA surveillance pathway_Homo sapiens_hsa030150.95863247
73Lysine degradation_Homo sapiens_hsa003100.95786372
74Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.94326933
75Homologous recombination_Homo sapiens_hsa034400.93895245
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92535334
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92086375
78Ether lipid metabolism_Homo sapiens_hsa005650.89855634
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.89213265
80Glucagon signaling pathway_Homo sapiens_hsa049220.89146890
81Alzheimers disease_Homo sapiens_hsa050100.89029144
82Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88395068
83Prolactin signaling pathway_Homo sapiens_hsa049170.88227629
84Renal cell carcinoma_Homo sapiens_hsa052110.87290188
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.86486893
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.86174735
87Proteoglycans in cancer_Homo sapiens_hsa052050.85106016
88Axon guidance_Homo sapiens_hsa043600.84321129
89Regulation of autophagy_Homo sapiens_hsa041400.83713167
90Pancreatic cancer_Homo sapiens_hsa052120.83019124
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.82832263
92Insulin resistance_Homo sapiens_hsa049310.80601107
93Endometrial cancer_Homo sapiens_hsa052130.80224801
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79738946
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76927474
96Circadian rhythm_Homo sapiens_hsa047100.76830096
97Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.74983322
98Viral carcinogenesis_Homo sapiens_hsa052030.74512960
99Cysteine and methionine metabolism_Homo sapiens_hsa002700.74385946
100N-Glycan biosynthesis_Homo sapiens_hsa005100.73602545
101Hepatitis B_Homo sapiens_hsa051610.72409525
102Insulin signaling pathway_Homo sapiens_hsa049100.70610264
103Systemic lupus erythematosus_Homo sapiens_hsa053220.69493071
104Colorectal cancer_Homo sapiens_hsa052100.69277676
105AMPK signaling pathway_Homo sapiens_hsa041520.68464006
106Calcium signaling pathway_Homo sapiens_hsa040200.67724510
107Steroid biosynthesis_Homo sapiens_hsa001000.67643525
108Glycerolipid metabolism_Homo sapiens_hsa005610.66451232
109ABC transporters_Homo sapiens_hsa020100.66239234
110Pathways in cancer_Homo sapiens_hsa052000.65060958
111Phenylalanine metabolism_Homo sapiens_hsa003600.63183835
112Huntingtons disease_Homo sapiens_hsa050160.60554903
113cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60082625
114Gastric acid secretion_Homo sapiens_hsa049710.59695802
115B cell receptor signaling pathway_Homo sapiens_hsa046620.59338361
116Hepatitis C_Homo sapiens_hsa051600.58999508
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58608644
118Nucleotide excision repair_Homo sapiens_hsa034200.58336684
119Fructose and mannose metabolism_Homo sapiens_hsa000510.58120199
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57939979
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56958827
122Pentose and glucuronate interconversions_Homo sapiens_hsa000400.56443257
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56393860
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.54150735
125Oxytocin signaling pathway_Homo sapiens_hsa049210.52930443
126GABAergic synapse_Homo sapiens_hsa047270.51548593
127Tyrosine metabolism_Homo sapiens_hsa003500.49291159
128TNF signaling pathway_Homo sapiens_hsa046680.49261993
129Focal adhesion_Homo sapiens_hsa045100.48823870
130Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47850415
131Insulin secretion_Homo sapiens_hsa049110.47700858
132Fat digestion and absorption_Homo sapiens_hsa049750.47567523
133PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47558907
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.44998128
135Tight junction_Homo sapiens_hsa045300.44889912
136Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.43399313
137Dorso-ventral axis formation_Homo sapiens_hsa043200.42982343
138Complement and coagulation cascades_Homo sapiens_hsa046100.42682568
139Circadian entrainment_Homo sapiens_hsa047130.41165868
140Type II diabetes mellitus_Homo sapiens_hsa049300.40410538
141Salivary secretion_Homo sapiens_hsa049700.40277137
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.40184028
143Glutamatergic synapse_Homo sapiens_hsa047240.39502782
144Renin secretion_Homo sapiens_hsa049240.38998957
145Retinol metabolism_Homo sapiens_hsa008300.38419642
146cAMP signaling pathway_Homo sapiens_hsa040240.38348416
147alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38148861
148Sphingolipid signaling pathway_Homo sapiens_hsa040710.38079349
149Metabolic pathways_Homo sapiens_hsa011000.37764697
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37652812
151Sulfur metabolism_Homo sapiens_hsa009200.36626366
152Viral myocarditis_Homo sapiens_hsa054160.36396550
153Alcoholism_Homo sapiens_hsa050340.35749977
154Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34861188
155Ovarian steroidogenesis_Homo sapiens_hsa049130.33787606
156NF-kappa B signaling pathway_Homo sapiens_hsa040640.32859971
157Chemical carcinogenesis_Homo sapiens_hsa052040.32696261
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32675309
159Galactose metabolism_Homo sapiens_hsa000520.32631498
160Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31820034
161Vitamin digestion and absorption_Homo sapiens_hsa049770.31756767
162Caffeine metabolism_Homo sapiens_hsa002320.30841971
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.30442950
164Steroid hormone biosynthesis_Homo sapiens_hsa001400.29178729
165Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.27952882
166Histidine metabolism_Homo sapiens_hsa003400.27723878
167Olfactory transduction_Homo sapiens_hsa047400.27270135

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