MFN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.82358142
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.66166221
3cardiac myofibril assembly (GO:0055003)5.46386140
4tricarboxylic acid cycle (GO:0006099)5.34658263
5positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)5.28163492
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.24653211
7carnitine shuttle (GO:0006853)4.99301698
8regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.94212322
9plasma membrane repair (GO:0001778)4.93978806
10myofibril assembly (GO:0030239)4.90669858
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.88785715
12cardiac muscle contraction (GO:0060048)4.69730127
13actin-myosin filament sliding (GO:0033275)4.65431977
14muscle filament sliding (GO:0030049)4.65431977
15fatty acid transmembrane transport (GO:1902001)4.54403828
16cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.50334385
17regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.49003878
18regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)4.43749925
19regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.43509991
20regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.29370766
21ventricular cardiac muscle cell action potential (GO:0086005)4.12219251
22regulation of acyl-CoA biosynthetic process (GO:0050812)4.11829610
23cell communication involved in cardiac conduction (GO:0086065)4.11780016
24regulation of skeletal muscle contraction (GO:0014819)4.10574270
25cell-substrate adherens junction assembly (GO:0007045)4.07262414
26focal adhesion assembly (GO:0048041)4.07262414
27response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.04532014
28regulation of actin filament-based movement (GO:1903115)4.02591805
29skeletal muscle contraction (GO:0003009)4.02133984
30sarcoplasmic reticulum calcium ion transport (GO:0070296)4.01242891
31cell communication by electrical coupling (GO:0010644)3.99512663
32carnitine transmembrane transport (GO:1902603)3.94638824
332-oxoglutarate metabolic process (GO:0006103)3.89005839
34NADH metabolic process (GO:0006734)3.87421320
35regulation of membrane repolarization (GO:0060306)3.86277228
36striated muscle contraction (GO:0006941)3.84391761
37adherens junction assembly (GO:0034333)3.83609528
38cardiac muscle cell development (GO:0055013)3.81549153
39regulation of cell communication by electrical coupling (GO:0010649)3.78586787
40regulation of cofactor metabolic process (GO:0051193)3.78426405
41regulation of coenzyme metabolic process (GO:0051196)3.78426405
42actin-mediated cell contraction (GO:0070252)3.78403730
43actomyosin structure organization (GO:0031032)3.77794662
44cell-substrate junction assembly (GO:0007044)3.75023630
45regulation of relaxation of muscle (GO:1901077)3.74892138
46carnitine transport (GO:0015879)3.71271022
47amino-acid betaine transport (GO:0015838)3.71271022
48cardiac muscle hypertrophy (GO:0003300)3.69590075
49lysine metabolic process (GO:0006553)3.63461452
50lysine catabolic process (GO:0006554)3.63461452
51striated muscle hypertrophy (GO:0014897)3.54698846
52aspartate family amino acid catabolic process (GO:0009068)3.53318840
53cardiac cell development (GO:0055006)3.53171515
54adult heart development (GO:0007512)3.50924038
55cytoskeletal anchoring at plasma membrane (GO:0007016)3.47041534
56regulation of sequestering of triglyceride (GO:0010889)3.46139340
57bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44674533
58regulation of striated muscle contraction (GO:0006942)3.42467132
59regulation of fatty acid oxidation (GO:0046320)3.41084171
60succinate metabolic process (GO:0006105)3.39587127
61positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.39532552
62regulation of sarcomere organization (GO:0060297)3.36939786
63heart trabecula formation (GO:0060347)3.33063561
64regulation of the force of heart contraction (GO:0002026)3.32202569
65membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.31110691
66cardiac muscle tissue morphogenesis (GO:0055008)3.26898215
67fatty acid beta-oxidation (GO:0006635)3.25945514
68desmosome organization (GO:0002934)3.25018565
69oxaloacetate metabolic process (GO:0006107)3.24464650
70muscle contraction (GO:0006936)3.23443044
71protein localization to endosome (GO:0036010)3.23012138
72Golgi transport vesicle coating (GO:0048200)3.22307878
73COPI coating of Golgi vesicle (GO:0048205)3.22307878
74regulation of calcium ion transmembrane transport (GO:1903169)3.18679743
75regulation of calcium ion transmembrane transporter activity (GO:1901019)3.18679743
76skeletal muscle adaptation (GO:0043501)3.18316992
77positive regulation of myotube differentiation (GO:0010831)3.16339799
78striated muscle adaptation (GO:0014888)3.16004134
79negative regulation of potassium ion transport (GO:0043267)3.15659995
80regulation of early endosome to late endosome transport (GO:2000641)3.14699600
81regulation of NFAT protein import into nucleus (GO:0051532)3.12768188
82cardiac muscle cell action potential involved in contraction (GO:0086002)3.12482555
83ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.11951231
84creatine metabolic process (GO:0006600)3.10906456
85cardiac muscle cell action potential (GO:0086001)3.08628965
86muscle hypertrophy (GO:0014896)3.07848913
87regulation of sulfur metabolic process (GO:0042762)3.06640667
88negative regulation of necroptotic process (GO:0060546)3.06090909
89response to inactivity (GO:0014854)3.04447415
90epithelial cell-cell adhesion (GO:0090136)3.01839665
91cellular response to epinephrine stimulus (GO:0071872)3.01392774
92cardiac conduction (GO:0061337)2.98819775
93regulation of heart rate (GO:0002027)2.96971593
94muscle tissue morphogenesis (GO:0060415)2.96014608
95actin filament-based movement (GO:0030048)2.95780186
96negative regulation of erythrocyte differentiation (GO:0045647)2.95761849
97hemidesmosome assembly (GO:0031581)2.95423369
98muscle hypertrophy in response to stress (GO:0003299)2.95252966
99cardiac muscle adaptation (GO:0014887)2.95252966
100cardiac muscle hypertrophy in response to stress (GO:0014898)2.95252966
101glycogen catabolic process (GO:0005980)2.93237269
102negative regulation of cytosolic calcium ion concentration (GO:0051481)2.93070756
103gluconeogenesis (GO:0006094)2.92971346
104regulation of cardiac muscle contraction (GO:0055117)2.92900391
105retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.92874018
106tricarboxylic acid metabolic process (GO:0072350)2.92409931
107relaxation of cardiac muscle (GO:0055119)2.92396556
108regulation of synapse structural plasticity (GO:0051823)2.91623196
109sodium ion export (GO:0071436)2.90668067
110muscle system process (GO:0003012)2.90600946
111regulation of heart rate by cardiac conduction (GO:0086091)2.89617526
112positive regulation of potassium ion transmembrane transport (GO:1901381)2.89603988
113regulation of cardiac muscle cell contraction (GO:0086004)2.88741788
114regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.87975546
115cellular ketone body metabolic process (GO:0046950)2.87016825
116positive regulation of cation channel activity (GO:2001259)2.86029312
117fatty acid catabolic process (GO:0009062)2.83929337
118activation of protein kinase A activity (GO:0034199)2.83500242
119detection of calcium ion (GO:0005513)2.82175971
120positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.80422133
121acetyl-CoA metabolic process (GO:0006084)2.80036269
122quaternary ammonium group transport (GO:0015697)2.79768697
123response to muscle activity (GO:0014850)2.79376127
124positive regulation of fatty acid oxidation (GO:0046321)2.79198137
125glucan catabolic process (GO:0009251)2.78040315
126regulation of heart contraction (GO:0008016)2.76596680
127stress fiber assembly (GO:0043149)2.75415696
128potassium ion import (GO:0010107)2.74300509
129fatty acid oxidation (GO:0019395)2.74244311
130positive regulation of receptor recycling (GO:0001921)2.71655568
131hexose biosynthetic process (GO:0019319)2.70528982
132glycolytic process (GO:0006096)2.67665096
133response to epinephrine (GO:0071871)2.62078869
134muscle adaptation (GO:0043500)2.60735090
1353-UTR-mediated mRNA stabilization (GO:0070935)2.58476396
136negative regulation of myotube differentiation (GO:0010832)2.57393379
137heart process (GO:0003015)2.54676788
138heart contraction (GO:0060047)2.54676788
139monosaccharide biosynthetic process (GO:0046364)2.51790687
140negative regulation of cell size (GO:0045792)2.51244886
141regulation of cardioblast differentiation (GO:0051890)2.49695091
142barbed-end actin filament capping (GO:0051016)2.49636595
143cellular polysaccharide catabolic process (GO:0044247)2.46140330
144fructose metabolic process (GO:0006000)2.46066300

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.95413745
2EZH2_22144423_ChIP-Seq_EOC_Human3.51472324
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42334955
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.28165836
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.20521935
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.94000659
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.55520395
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.51773590
9ELK3_25401928_ChIP-Seq_HUVEC_Human2.20864447
10RXR_22158963_ChIP-Seq_LIVER_Mouse2.19503538
11ZNF263_19887448_ChIP-Seq_K562_Human2.18793397
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.10682433
13* RACK7_27058665_Chip-Seq_MCF-7_Human2.08272189
14DROSHA_22980978_ChIP-Seq_HELA_Human2.07686336
15* TBX20_22328084_ChIP-Seq_HEART_Mouse2.06768571
16* TBX20_22080862_ChIP-Seq_HEART_Mouse2.06768571
17* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.01908682
18MYC_22102868_ChIP-Seq_BL_Human1.99799675
19TCF7_22412390_ChIP-Seq_EML_Mouse1.99517857
20PPARA_22158963_ChIP-Seq_LIVER_Mouse1.98649235
21* LXR_22158963_ChIP-Seq_LIVER_Mouse1.98528296
22ESR1_20079471_ChIP-ChIP_T-47D_Human1.96951307
23TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96067504
24VDR_21846776_ChIP-Seq_THP-1_Human1.87506056
25EGR1_19374776_ChIP-ChIP_THP-1_Human1.86319510
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.84343481
27SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.84078575
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.82026287
29RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.80657745
30* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.79326664
31* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.77862466
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.77554383
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.74257410
34NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71497421
35KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.71179851
36RARB_27405468_Chip-Seq_BRAIN_Mouse1.70348073
37MTF2_20144788_ChIP-Seq_MESCs_Mouse1.68098493
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67760981
39SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65201218
40EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.62647523
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.62549088
42RNF2_18974828_ChIP-Seq_MESCs_Mouse1.62549088
43RARG_19884340_ChIP-ChIP_MEFs_Mouse1.60331522
44SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.56726121
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56165897
46NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.50067356
47SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49440730
48* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.47126342
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.45807147
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.45463255
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44842304
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.42664936
53* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.39774533
54TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.39112232
55EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38250132
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.37267964
57KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33772022
58CLOCK_20551151_ChIP-Seq_293T_Human1.33570230
59SUZ12_27294783_Chip-Seq_ESCs_Mouse1.32710660
60JARID2_20075857_ChIP-Seq_MESCs_Mouse1.32499050
61SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31631506
62* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30202557
63* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.29754809
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28205508
65JARID2_20064375_ChIP-Seq_MESCs_Mouse1.27765316
66REST_18959480_ChIP-ChIP_MESCs_Mouse1.26846961
67SOX9_24532713_ChIP-Seq_HFSC_Mouse1.25985380
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.25634703
69CTCF_27219007_Chip-Seq_Bcells_Human1.25309752
70* ATF3_27146783_Chip-Seq_COLON_Human1.25084412
71BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24354796
72ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.24101827
73EZH2_27304074_Chip-Seq_ESCs_Mouse1.22992526
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22901023
75TRIM28_21343339_ChIP-Seq_HEK293_Human1.22865833
76NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22429484
77SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.21894440
78REST_21632747_ChIP-Seq_MESCs_Mouse1.21894239
79GATA4_21415370_ChIP-Seq_HL-1_Mouse1.20773851
80* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20643122
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.20534372
82LXR_22292898_ChIP-Seq_THP-1_Human1.19561426
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.19378616
84TET1_21451524_ChIP-Seq_MESCs_Mouse1.18452389
85KDM2B_26808549_Chip-Seq_K562_Human1.17614113
86GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.16893645
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16846319
88CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.15895723
89* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15564525
90* NCOR1_26117541_ChIP-Seq_K562_Human1.15259500
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15075372
92ZNF274_21170338_ChIP-Seq_K562_Hela1.14784477
93MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.14673757
94SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.13596388
95* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13440213
96* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.12868629
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12833114
98FOXA2_19822575_ChIP-Seq_HepG2_Human1.12714228
99* SA1_27219007_Chip-Seq_ERYTHROID_Human1.11988682
100BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11423545
101NFIB_24661679_ChIP-Seq_LUNG_Mouse1.11391058
102TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11281151
103EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10273911
104GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09426382
105* UBF1/2_26484160_Chip-Seq_HMECs_Human1.07519484
106ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.07485538
107DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07191548
108* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06812125
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06527204
110WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06470680
111RNF2_27304074_Chip-Seq_ESCs_Mouse1.05185792
112ZFP281_27345836_Chip-Seq_ESCs_Mouse1.04834571
113SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04824148
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.04582997
115E2F7_22180533_ChIP-Seq_HELA_Human1.02928374
116* MAF_26560356_Chip-Seq_TH1_Human1.01921937
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01454351
118* SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.01037859
119HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00131846
120SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00067380
121GBX2_23144817_ChIP-Seq_PC3_Human0.99575603
122SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.97720692
123FOXM1_23109430_ChIP-Seq_U2OS_Human0.97003258
124ERG_21242973_ChIP-ChIP_JURKAT_Human0.95169896
125SMAD4_21741376_ChIP-Seq_HESCs_Human0.94335682
126* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.94119987
127KDM2B_26808549_Chip-Seq_DND41_Human0.93141001
128WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.92519518
129CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.92277287
130EED_16625203_ChIP-ChIP_MESCs_Mouse0.91760006
131TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.90786194
132PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.90781321
133SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90424949
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.89529998
135SMC4_20622854_ChIP-Seq_HELA_Human0.89513662
136* TP63_22573176_ChIP-Seq_HFKS_Human0.89371260
137KLF4_19829295_ChIP-Seq_ESCs_Human0.89168227
138TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87085215
139AR_19668381_ChIP-Seq_PC3_Human0.86815845
140AHR_22903824_ChIP-Seq_MCF-7_Human0.86301268
141AR_21572438_ChIP-Seq_LNCaP_Human0.85942405
142BCAT_22108803_ChIP-Seq_LS180_Human0.85762093
143SMAD3_21741376_ChIP-Seq_HESCs_Human0.85010611
144GATA1_19941826_ChIP-Seq_K562_Human0.84849314
145SMAD4_21799915_ChIP-Seq_A2780_Human0.84006132
146RING1B_27294783_Chip-Seq_ESCs_Mouse0.83486557
147SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.78846876
148TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.78444913
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.78353095
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.78116735
151TET1_21490601_ChIP-Seq_MESCs_Mouse0.78080965
152P68_20966046_ChIP-Seq_HELA_Human0.78010328
153* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.77787041
154PPAR_26484153_Chip-Seq_NCI-H1993_Human0.77322738
155* CREB1_26743006_Chip-Seq_LNCaP_Human0.76818939
156SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.76648581
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.75774704
158NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.75015815
159ZNF217_24962896_ChIP-Seq_MCF-7_Human0.74860334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.03304726
2MP0003646_muscle_fatigue4.86632980
3MP0000751_myopathy4.70386673
4MP0004084_abnormal_cardiac_muscle4.28326380
5MP0004215_abnormal_myocardial_fiber3.84657727
6MP0005451_abnormal_body_composition3.82051683
7MP0004036_abnormal_muscle_relaxation3.61375584
8MP0000749_muscle_degeneration3.31958956
9MP0005330_cardiomyopathy3.09316437
10MP0004130_abnormal_muscle_cell3.01371247
11MP0004087_abnormal_muscle_fiber2.68630133
12MP0002972_abnormal_cardiac_muscle2.48798253
13MP0004145_abnormal_muscle_electrophysio2.45992674
14MP0005620_abnormal_muscle_contractility2.43324269
15MP0003137_abnormal_impulse_conducting2.33227402
16MP0008775_abnormal_heart_ventricle2.30265273
17MP0003566_abnormal_cell_adhesion2.18765837
18MP0002269_muscular_atrophy2.17097607
19MP0002106_abnormal_muscle_physiology2.15667558
20MP0000750_abnormal_muscle_regeneration2.10541192
21MP0000747_muscle_weakness2.08989415
22MP0005385_cardiovascular_system_phenoty2.04131933
23MP0001544_abnormal_cardiovascular_syste2.04131933
24MP0004859_abnormal_synaptic_plasticity2.01137239
25MP0004484_altered_response_of1.99396344
26MP0002877_abnormal_melanocyte_morpholog1.98496457
27MP0006138_congestive_heart_failure1.93836697
28MP0005670_abnormal_white_adipose1.93529371
29MP0010630_abnormal_cardiac_muscle1.93198510
30MP0004085_abnormal_heartbeat1.87962428
31MP0000759_abnormal_skeletal_muscle1.84605870
32MP0005409_darkened_coat_color1.80282705
33MP0004233_abnormal_muscle_weight1.77265253
34MP0005369_muscle_phenotype1.76240345
35MP0005666_abnormal_adipose_tissue1.72973234
36MP0000733_abnormal_muscle_development1.59902110
37MP0010234_abnormal_vibrissa_follicle1.59860261
38MP0003221_abnormal_cardiomyocyte_apopto1.49388407
39MP0002822_catalepsy1.49264781
40MP0002909_abnormal_adrenal_gland1.48045989
41* MP0006036_abnormal_mitochondrial_physio1.47561255
42MP0008260_abnormal_autophagy1.43726053
43MP0004510_myositis1.37101182
44MP0001661_extended_life_span1.36378616
45MP0008438_abnormal_cutaneous_collagen1.36130922
46MP0005085_abnormal_gallbladder_physiolo1.32432331
47MP0005360_urolithiasis1.31725263
48MP0000013_abnormal_adipose_tissue1.31635172
49MP0002332_abnormal_exercise_endurance1.31608057
50MP0002139_abnormal_hepatobiliary_system1.31553962
51MP0005375_adipose_tissue_phenotype1.26046609
52MP0000579_abnormal_nail_morphology1.23717220
53MP0001849_ear_inflammation1.23271568
54MP0009780_abnormal_chondrocyte_physiolo1.21977195
55MP0003453_abnormal_keratinocyte_physiol1.21541107
56MP0004185_abnormal_adipocyte_glucose1.20199171
57MP0003191_abnormal_cellular_cholesterol1.17661093
58MP0003091_abnormal_cell_migration1.17653182
59MP0008961_abnormal_basal_metabolism1.17330541
60MP0004270_analgesia1.16862813
61MP0003828_pulmonary_edema1.16708521
62MP0003635_abnormal_synaptic_transmissio1.15690686
63MP0005058_abnormal_lysosome_morphology1.13866526
64MP0004272_abnormal_basement_membrane1.13331171
65MP0005076_abnormal_cell_differentiation1.11856416
66MP0005365_abnormal_bile_salt1.10208835
67MP0010352_gastrointestinal_tract_polyps1.09847418
68MP0003329_amyloid_beta_deposits1.09711220
69MP0003705_abnormal_hypodermis_morpholog1.07428292
70MP0005535_abnormal_body_temperature1.06370904
71MP0010329_abnormal_lipoprotein_level1.05056163
72MP0002971_abnormal_brown_adipose1.03961779
73MP0002234_abnormal_pharynx_morphology1.02147830
74MP0002127_abnormal_cardiovascular_syste1.01318797
75MP0002796_impaired_skin_barrier0.99770906
76MP0004043_abnormal_pH_regulation0.97973780
77MP0002118_abnormal_lipid_homeostasis0.93029180
78MP0000003_abnormal_adipose_tissue0.90697572
79MP0000230_abnormal_systemic_arterial0.90450956
80MP0002078_abnormal_glucose_homeostasis0.86853687
81MP0010368_abnormal_lymphatic_system0.86376652
82MP0009745_abnormal_behavioral_response0.85248922
83MP0003656_abnormal_erythrocyte_physiolo0.84863958
84MP0002108_abnormal_muscle_morphology0.84145930
85MP0002063_abnormal_learning/memory/cond0.83732852
86MP0004858_abnormal_nervous_system0.82920235
87MP0005275_abnormal_skin_tensile0.81162905
88MP0000467_abnormal_esophagus_morphology0.80717063
89MP0005332_abnormal_amino_acid0.80245707
90MP0004924_abnormal_behavior0.79867348
91MP0005386_behavior/neurological_phenoty0.79867348
92MP0000678_abnormal_parathyroid_gland0.79061010
93MP0001730_embryonic_growth_arrest0.78954635
94MP0009046_muscle_twitch0.78936877
95MP0001958_emphysema0.78854283
96MP0003950_abnormal_plasma_membrane0.78330066
97MP0002060_abnormal_skin_morphology0.78314212
98MP0003806_abnormal_nucleotide_metabolis0.78150141
99MP0003045_fibrosis0.78098682
100MP0002064_seizures0.77980503
101MP0008875_abnormal_xenobiotic_pharmacok0.77206914
102MP0003300_gastrointestinal_ulcer0.77130646
103MP0005266_abnormal_metabolism0.76518641
104MP0005165_increased_susceptibility_to0.76461380
105MP0000266_abnormal_heart_morphology0.76226849
106MP0001348_abnormal_lacrimal_gland0.75797408
107MP0005023_abnormal_wound_healing0.75751668
108MP0005319_abnormal_enzyme/_coenzyme0.75532211
109MP0008569_lethality_at_weaning0.75462421
110MP0005584_abnormal_enzyme/coenzyme_acti0.75173414
111MP0003252_abnormal_bile_duct0.74140209
112MP0005083_abnormal_biliary_tract0.73996493
113MP0003879_abnormal_hair_cell0.72086746
114MP0009840_abnormal_foam_cell0.71226394
115MP0002272_abnormal_nervous_system0.69557792
116* MP0006035_abnormal_mitochondrial_morpho0.69501458
117MP0003880_abnormal_central_pattern0.69315346
118MP0009672_abnormal_birth_weight0.68726106
119MP0003279_aneurysm0.68446002
120MP0000343_altered_response_to0.68174954
121MP0005623_abnormal_meninges_morphology0.68084602
122MP0000762_abnormal_tongue_morphology0.66399480
123MP0001440_abnormal_grooming_behavior0.65990364
124MP0003195_calcinosis0.64629873
125MP0005334_abnormal_fat_pad0.63934781
126MP0008874_decreased_physiological_sensi0.62908455
127MP0002128_abnormal_blood_circulation0.62332744
128MP0002896_abnormal_bone_mineralization0.62300331
129MP0005501_abnormal_skin_physiology0.61784972
130MP0000858_altered_metastatic_potential0.61009317
131MP0005187_abnormal_penis_morphology0.60928705
132MP0001915_intracranial_hemorrhage0.60570535
133MP0008004_abnormal_stomach_pH0.59906647
134MP0002735_abnormal_chemical_nociception0.59834657
135MP0003633_abnormal_nervous_system0.59709646
136MP0000767_abnormal_smooth_muscle0.58174988
137MP0004947_skin_inflammation0.58004473
138MP0003984_embryonic_growth_retardation0.57873329
139MP0005448_abnormal_energy_balance0.57806037
140MP0002572_abnormal_emotion/affect_behav0.55625284
141MP0002734_abnormal_mechanical_nocicepti0.53232203
142MP0005167_abnormal_blood-brain_barrier0.53229735
143MP0003075_altered_response_to0.52849604

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.52216323
2Exercise-induced myalgia (HP:0003738)5.89654237
3Exercise-induced muscle cramps (HP:0003710)5.25128467
4Calf muscle hypertrophy (HP:0008981)5.20676416
5Ventricular tachycardia (HP:0004756)4.92459269
6Muscle hypertrophy of the lower extremities (HP:0008968)4.90583744
7Myoglobinuria (HP:0002913)4.88698874
8Muscle fiber splitting (HP:0003555)4.78461296
9Atrial fibrillation (HP:0005110)4.61715067
10Hyporeflexia of lower limbs (HP:0002600)4.60853259
11Centrally nucleated skeletal muscle fibers (HP:0003687)4.56818362
12Primary atrial arrhythmia (HP:0001692)4.35263355
13Abnormality of the calf musculature (HP:0001430)4.33751017
14Bundle branch block (HP:0011710)4.23071594
15Supraventricular tachycardia (HP:0004755)4.15831818
16Supraventricular arrhythmia (HP:0005115)4.08196218
17Syncope (HP:0001279)4.01226079
18Lipoatrophy (HP:0100578)3.93027648
19Right ventricular cardiomyopathy (HP:0011663)3.89721216
20Abnormality of the left ventricular outflow tract (HP:0011103)3.89248332
21Subaortic stenosis (HP:0001682)3.89248332
22Difficulty running (HP:0009046)3.79143007
23Myopathic facies (HP:0002058)3.69581926
24EMG: myopathic abnormalities (HP:0003458)3.68555602
25Prolonged QT interval (HP:0001657)3.67555064
26Palpitations (HP:0001962)3.65279751
27Asymmetric septal hypertrophy (HP:0001670)3.63233314
28Ventricular fibrillation (HP:0001663)3.57848106
29Increased connective tissue (HP:0009025)3.56821716
30Ventricular arrhythmia (HP:0004308)3.48454738
31Rhabdomyolysis (HP:0003201)3.46733685
32Myotonia (HP:0002486)3.42304816
33Heart block (HP:0012722)3.41095245
34Atrioventricular block (HP:0001678)3.35192013
35Dilated cardiomyopathy (HP:0001644)3.32510845
36Abnormal atrioventricular conduction (HP:0005150)3.21130675
37Ketoacidosis (HP:0001993)3.20729626
38Type 1 muscle fiber predominance (HP:0003803)2.91941271
39Difficulty climbing stairs (HP:0003551)2.90823694
40Abnormal EKG (HP:0003115)2.83635408
41Muscle stiffness (HP:0003552)2.81159774
42Ketosis (HP:0001946)2.80351130
43Increased variability in muscle fiber diameter (HP:0003557)2.76136856
44Round ear (HP:0100830)2.75681507
45Muscle fiber inclusion bodies (HP:0100299)2.72119309
46Hypoglycemic coma (HP:0001325)2.69945645
47Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.62539644
48Pheochromocytoma (HP:0002666)2.62329502
49Abnormality of fatty-acid metabolism (HP:0004359)2.58555504
50Spinal rigidity (HP:0003306)2.54798762
51Abnormality of skeletal muscle fiber size (HP:0012084)2.50485912
52Ulnar deviation of the wrist (HP:0003049)2.38242487
53Left ventricular hypertrophy (HP:0001712)2.36887581
54Progressive muscle weakness (HP:0003323)2.32258064
55* Abnormality of the foot musculature (HP:0001436)2.29870212
56Distal arthrogryposis (HP:0005684)2.29407253
57Limb-girdle muscle atrophy (HP:0003797)2.26984858
58* Foot dorsiflexor weakness (HP:0009027)2.25419237
59Neuroendocrine neoplasm (HP:0100634)2.23680345
60Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23585217
61Dicarboxylic aciduria (HP:0003215)2.23585217
62EMG: neuropathic changes (HP:0003445)2.23158289
63Hyperammonemia (HP:0001987)2.21255269
64Ragged-red muscle fibers (HP:0003200)2.16949828
65Bulbar palsy (HP:0001283)2.16570731
66Achilles tendon contracture (HP:0001771)2.16341938
67Conjunctival hamartoma (HP:0100780)2.14592935
68Hyperglycinuria (HP:0003108)2.10917846
69Hepatic necrosis (HP:0002605)2.10789709
70Neck muscle weakness (HP:0000467)2.08842191
71Cholelithiasis (HP:0001081)2.08836498
72Increased muscle lipid content (HP:0009058)2.07084103
73Hamartoma of the eye (HP:0010568)2.06136403
74Calcaneovalgus deformity (HP:0001848)2.04606890
75Nemaline bodies (HP:0003798)2.03154071
76Mildly elevated creatine phosphokinase (HP:0008180)2.01175870
77Abnormality of the Achilles tendon (HP:0005109)2.00352684
78Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.98499455
79Abnormal mitochondria in muscle tissue (HP:0008316)1.98182517
80Abnormality of the salivary glands (HP:0010286)1.97256808
81Cholecystitis (HP:0001082)1.96941186
82Abnormal gallbladder physiology (HP:0012438)1.96941186
83Areflexia of lower limbs (HP:0002522)1.96912981
84Distal lower limb muscle weakness (HP:0009053)1.94204818
85Cerebral edema (HP:0002181)1.94126977
86Protrusio acetabuli (HP:0003179)1.92184042
87Hypoalphalipoproteinemia (HP:0003233)1.89608071
88Facial diplegia (HP:0001349)1.88814908
89Distal lower limb amyotrophy (HP:0008944)1.88574323
90Abnormality of serine family amino acid metabolism (HP:0010894)1.87272256
91Abnormality of glycine metabolism (HP:0010895)1.87272256
92Lower limb amyotrophy (HP:0007210)1.86835019
93Abnormal gallbladder morphology (HP:0012437)1.86768171
94Testicular atrophy (HP:0000029)1.86646967
95Cerebral aneurysm (HP:0004944)1.86579760
96Sudden cardiac death (HP:0001645)1.86120302
97Abnormality of the tricuspid valve (HP:0001702)1.85868895
98Myokymia (HP:0002411)1.85340157
99Palmoplantar keratoderma (HP:0000982)1.84763911
100Abnormality of the calcaneus (HP:0008364)1.84677806
101Hyperinsulinemic hypoglycemia (HP:0000825)1.83746459
102Rimmed vacuoles (HP:0003805)1.82748328
103Acute encephalopathy (HP:0006846)1.81737139
104Athetosis (HP:0002305)1.81645059
105Hyperacusis (HP:0010780)1.80056537
106Rapidly progressive (HP:0003678)1.79328996
107Acute necrotizing encephalopathy (HP:0006965)1.76130938
108Back pain (HP:0003418)1.75875322
109Lymphangioma (HP:0100764)1.75623809
110Frequent falls (HP:0002359)1.74672265
111Muscular dystrophy (HP:0003560)1.74622757
112Gowers sign (HP:0003391)1.74272833
113Congestive heart failure (HP:0001635)1.73648084
114Distal upper limb amyotrophy (HP:0007149)1.73571598
115Upper limb amyotrophy (HP:0009129)1.73571598
116Obstructive sleep apnea (HP:0002870)1.73078038
117Skin nodule (HP:0200036)1.72371552
118Polycythemia (HP:0001901)1.71924305
119Gout (HP:0001997)1.70682704
120Slender build (HP:0001533)1.69772731
121Scapular winging (HP:0003691)1.69748653
122Premature rupture of membranes (HP:0001788)1.69679565
123Generalized muscle weakness (HP:0003324)1.69446474
124Deformed tarsal bones (HP:0008119)1.67186875
125Broad metatarsal (HP:0001783)1.67001060
126Reticulocytosis (HP:0001923)1.66205241
127Neoplasm of the adrenal gland (HP:0100631)1.65552706
128Oligomenorrhea (HP:0000876)1.64545107
129Visual hallucinations (HP:0002367)1.63555362
130Hepatocellular necrosis (HP:0001404)1.63408109
131Generalized amyotrophy (HP:0003700)1.63094359
132Ankyloglossia (HP:0010296)1.62272848
133Aneurysm (HP:0002617)1.61533965
134Fatigue (HP:0012378)1.59457294
135Resting tremor (HP:0002322)1.57668440
136Progressive external ophthalmoplegia (HP:0000590)1.56541489
137Advanced eruption of teeth (HP:0006288)1.54686307
138Abnormality of the shoulder girdle musculature (HP:0001435)1.48852308
139Cerebral inclusion bodies (HP:0100314)1.47411103
140Osteolytic defects of the hand bones (HP:0009699)1.47251606
141Osteolytic defects of the phalanges of the hand (HP:0009771)1.47251606

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.25572607
2PHKG13.69183782
3PHKG23.69183782
4PDK43.44627923
5PDK33.44627923
6LMTK23.28410453
7OBSCN3.18073254
8TRIB33.06326957
9PRPF4B2.86730767
10EEF2K2.81983642
11PKN22.61244438
12BCKDK2.27936405
13DMPK2.21032162
14MYLK2.20845230
15NEK12.15951942
16PINK11.99070927
17PDK21.98292182
18SMG11.98237171
19CDK121.97377517
20PRKD31.68447364
21IRAK31.53281979
22RIPK11.41591251
23PIK3CA1.39671475
24PAK31.39302540
25MAP2K41.38632152
26STK381.35601754
27PAK61.33235798
28MUSK1.32645719
29MAP3K41.31948823
30MAP3K91.30101864
31KSR21.28351393
32EPHA41.25667036
33MAP3K71.25070274
34NTRK31.21793800
35MST1R1.21404151
36MAP3K61.20742333
37TIE11.16639912
38RIPK41.11913816
39ARAF1.08260303
40DAPK21.07173788
41TAOK21.04024165
42MAP3K131.03497608
43WNK41.02382950
44MAPK121.00436865
45MARK10.99243804
46NEK90.98269304
47TRPM70.98132976
48MTOR0.96799778
49PRKD10.96269087
50SCYL20.95886329
51PTK2B0.94423425
52CAMKK10.94011837
53MINK10.93589050
54CAMK2D0.93570037
55PRKAA10.93514459
56STK240.91423303
57TAOK10.90018177
58EPHA20.89472088
59LATS20.87786563
60PDGFRA0.87733484
61SIK10.87272863
62CAMK1G0.84626347
63ICK0.83655645
64MOS0.83572885
65RET0.82877748
66CDC42BPA0.82355343
67PTK20.81887988
68MAP3K100.80346705
69RAF10.79119891
70ROCK10.78816412
71PRKCH0.77182468
72PDPK10.76055433
73PIK3CG0.75625878
74MET0.74650911
75PRKAA20.74563528
76INSRR0.74153655
77PDK10.71868347
78CAMK10.71143264
79CAMK1D0.70107867
80BMX0.69994863
81CAMK2A0.69852434
82MAPK110.68223847
83CAMK40.68220500
84GRK70.67869216
85SGK30.66085666
86NTRK10.64839525
87ILK0.64802639
88MAP3K50.64663969
89PAK40.64416113
90AKT20.64213764
91WNK10.63372925
92MAP2K30.62395031
93MAPKAPK30.57576380
94DAPK30.57043322
95NME10.55619156
96FER0.55395860
97CDK50.54111726
98MAP3K10.53676300
99MAP3K80.53228236
100PRKACG0.52211668
101RPS6KL10.51445522
102RPS6KC10.51445522
103CAMK2G0.49542712
104ZAP700.48919959
105STK110.47868981
106NTRK20.47290832
107MAP2K10.46917073
108KSR10.46795062
109PTK60.46705828
110PAK20.45416310
111EPHA30.45135592
112ERN10.43923790
113MAPK100.43783145
114BRAF0.43478811
115FGFR30.43452189
116SGK4940.43254872
117SGK2230.43254872
118PRKACB0.42050027
119PKN10.41953490
120STK40.41806524
121ROCK20.41322181
122TESK10.41181886
123SGK20.39229744
124MAPK40.39212087
125FGFR40.38967752
126SGK10.38246714
127MAPK70.38190087
128GRK50.38095363
129RPS6KA30.37880677
130PRKD20.37864061
131RPS6KA20.37819495
132MAP3K110.36924616
133PRKG20.36840792
134RPS6KB20.36706117
135PRKACA0.36404938
136PRKCE0.36081126
137MAP2K60.35904914
138CAMK2B0.35413920
139ALK0.35315552
140CAMKK20.32045493
141MAP3K20.30219233
142MAP3K30.30109797
143EPHB10.29654150
144MARK20.29359406
145PRKCG0.28548217

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.40287641
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.51500955
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.37133992
4Propanoate metabolism_Homo sapiens_hsa006402.88115852
5Cardiac muscle contraction_Homo sapiens_hsa042602.65342607
6Fatty acid degradation_Homo sapiens_hsa000712.64220027
7Dilated cardiomyopathy_Homo sapiens_hsa054142.32718224
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.20494354
9Fatty acid metabolism_Homo sapiens_hsa012122.17058630
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.12139289
11Carbon metabolism_Homo sapiens_hsa012002.01428104
12Pyruvate metabolism_Homo sapiens_hsa006201.83348295
13Butanoate metabolism_Homo sapiens_hsa006501.79698031
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77880405
15Nitrogen metabolism_Homo sapiens_hsa009101.71059921
16Pentose phosphate pathway_Homo sapiens_hsa000301.69403569
17Arginine biosynthesis_Homo sapiens_hsa002201.65715677
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.61565688
19PPAR signaling pathway_Homo sapiens_hsa033201.59438707
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50778526
21Parkinsons disease_Homo sapiens_hsa050121.42454924
22VEGF signaling pathway_Homo sapiens_hsa043701.39647155
23Chronic myeloid leukemia_Homo sapiens_hsa052201.38494992
24Non-small cell lung cancer_Homo sapiens_hsa052231.26942262
25Oxidative phosphorylation_Homo sapiens_hsa001901.26577534
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25068907
27Prion diseases_Homo sapiens_hsa050201.24740498
28Tryptophan metabolism_Homo sapiens_hsa003801.23892632
29Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22651291
30Glucagon signaling pathway_Homo sapiens_hsa049221.19584423
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.19336878
32Endometrial cancer_Homo sapiens_hsa052131.17451634
33Adherens junction_Homo sapiens_hsa045201.16306146
34Renal cell carcinoma_Homo sapiens_hsa052111.16262865
35Alzheimers disease_Homo sapiens_hsa050101.15540457
36Glioma_Homo sapiens_hsa052141.14094103
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11189149
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.10973172
39Biosynthesis of amino acids_Homo sapiens_hsa012301.10843437
40Acute myeloid leukemia_Homo sapiens_hsa052211.09625781
41Starch and sucrose metabolism_Homo sapiens_hsa005001.08126702
42Pancreatic cancer_Homo sapiens_hsa052121.08090217
43Fatty acid biosynthesis_Homo sapiens_hsa000611.08040040
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.04217145
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.04020296
46Bladder cancer_Homo sapiens_hsa052191.02398904
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.01274763
48Circadian entrainment_Homo sapiens_hsa047131.01133949
49Thyroid cancer_Homo sapiens_hsa052161.01083128
50Amoebiasis_Homo sapiens_hsa051460.99515184
51Adipocytokine signaling pathway_Homo sapiens_hsa049200.99423920
52Insulin resistance_Homo sapiens_hsa049310.98096548
53Primary bile acid biosynthesis_Homo sapiens_hsa001200.97391047
54Bile secretion_Homo sapiens_hsa049760.97017539
55beta-Alanine metabolism_Homo sapiens_hsa004100.96991033
56Insulin secretion_Homo sapiens_hsa049110.96281532
57ErbB signaling pathway_Homo sapiens_hsa040120.95621252
58Renin secretion_Homo sapiens_hsa049240.94599060
59Insulin signaling pathway_Homo sapiens_hsa049100.94571494
60Gastric acid secretion_Homo sapiens_hsa049710.93916970
61cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93871653
62Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.92843910
63AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92715310
64Oxytocin signaling pathway_Homo sapiens_hsa049210.92491693
65Calcium signaling pathway_Homo sapiens_hsa040200.91587212
66Type II diabetes mellitus_Homo sapiens_hsa049300.91398147
67Fatty acid elongation_Homo sapiens_hsa000620.90589175
68ECM-receptor interaction_Homo sapiens_hsa045120.90284155
69Olfactory transduction_Homo sapiens_hsa047400.89988378
70Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86667544
71GABAergic synapse_Homo sapiens_hsa047270.82168525
72Proteoglycans in cancer_Homo sapiens_hsa052050.81005855
73Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80776968
74AMPK signaling pathway_Homo sapiens_hsa041520.79270043
75Other glycan degradation_Homo sapiens_hsa005110.78302366
76Leukocyte transendothelial migration_Homo sapiens_hsa046700.78281619
77Long-term potentiation_Homo sapiens_hsa047200.76090101
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75934742
79Phenylalanine metabolism_Homo sapiens_hsa003600.75442863
80Peroxisome_Homo sapiens_hsa041460.75325918
81Salivary secretion_Homo sapiens_hsa049700.75228633
82Synaptic vesicle cycle_Homo sapiens_hsa047210.74860424
83Tight junction_Homo sapiens_hsa045300.72744809
84Small cell lung cancer_Homo sapiens_hsa052220.72724165
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.72460906
86Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72166455
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.71425926
88Huntingtons disease_Homo sapiens_hsa050160.71407004
89Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70675562
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.70543497
91Inositol phosphate metabolism_Homo sapiens_hsa005620.68550890
92Morphine addiction_Homo sapiens_hsa050320.65885376
93Cholinergic synapse_Homo sapiens_hsa047250.65708986
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.64817397
95Amphetamine addiction_Homo sapiens_hsa050310.64367211
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.63532899
97Glycerolipid metabolism_Homo sapiens_hsa005610.63327984
98cAMP signaling pathway_Homo sapiens_hsa040240.62901936
99Glutamatergic synapse_Homo sapiens_hsa047240.61848183
100Lysine degradation_Homo sapiens_hsa003100.61830934
101Platelet activation_Homo sapiens_hsa046110.59985508
102Notch signaling pathway_Homo sapiens_hsa043300.59720445
103Viral myocarditis_Homo sapiens_hsa054160.59554581
104Dopaminergic synapse_Homo sapiens_hsa047280.58922239
105Fat digestion and absorption_Homo sapiens_hsa049750.58627549
106B cell receptor signaling pathway_Homo sapiens_hsa046620.57945818
107GnRH signaling pathway_Homo sapiens_hsa049120.55898040
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.55025986
109Nicotine addiction_Homo sapiens_hsa050330.54787636
110Choline metabolism in cancer_Homo sapiens_hsa052310.54560122
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.53959763
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52985707
113Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51816976
114Fructose and mannose metabolism_Homo sapiens_hsa000510.51027164
115Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50886662
116Endocytosis_Homo sapiens_hsa041440.50193095
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49697543
118Prolactin signaling pathway_Homo sapiens_hsa049170.49590387
119FoxO signaling pathway_Homo sapiens_hsa040680.49297728
120Galactose metabolism_Homo sapiens_hsa000520.47679642
121Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.47304105
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.46242016
123Melanogenesis_Homo sapiens_hsa049160.45686127
124Taste transduction_Homo sapiens_hsa047420.45480857
125Gap junction_Homo sapiens_hsa045400.45461051
126Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44718284
127Prostate cancer_Homo sapiens_hsa052150.44548659
128Arginine and proline metabolism_Homo sapiens_hsa003300.44100316
129Dorso-ventral axis formation_Homo sapiens_hsa043200.41503698
130Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41346198
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41182293
132MicroRNAs in cancer_Homo sapiens_hsa052060.41110518
133MAPK signaling pathway_Homo sapiens_hsa040100.40813096
134Tyrosine metabolism_Homo sapiens_hsa003500.38243638
135Estrogen signaling pathway_Homo sapiens_hsa049150.38222143
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36442939
137HIF-1 signaling pathway_Homo sapiens_hsa040660.36331433
138Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34830045
139Circadian rhythm_Homo sapiens_hsa047100.34541221
140Focal adhesion_Homo sapiens_hsa045100.34155918
141Cysteine and methionine metabolism_Homo sapiens_hsa002700.33362967
142Cocaine addiction_Homo sapiens_hsa050300.33314092
143mTOR signaling pathway_Homo sapiens_hsa041500.33259807
144ABC transporters_Homo sapiens_hsa020100.32685227
145Pancreatic secretion_Homo sapiens_hsa049720.29130204

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