MFRP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the frizzled-related protein family. The encoded protein plays an important role in eye development and mutations in this gene have been associated with nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen. The protein is encoded by a bicistronic transcript which also encodes C1q and tumor necrosis factor related protein 5 (C1QTNF5). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1short-term memory (GO:0007614)7.83965773
2regulation of apoptotic cell clearance (GO:2000425)7.68850314
3diterpenoid biosynthetic process (GO:0016102)7.66240506
4regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)7.60711397
5regulation of lipoprotein metabolic process (GO:0050746)7.34122825
6positive regulation of osteoblast proliferation (GO:0033690)6.91187485
7regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)6.74967107
8regulation of antigen processing and presentation of peptide antigen (GO:0002583)6.32675440
9antigen processing and presentation via MHC class Ib (GO:0002475)6.16808504
10modulation by symbiont of host cellular process (GO:0044068)6.03353069
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.97412576
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.97412576
13regulation of clathrin-mediated endocytosis (GO:2000369)5.34512134
14terpenoid biosynthetic process (GO:0016114)5.10611455
15righting reflex (GO:0060013)4.98699262
16cellular response to electrical stimulus (GO:0071257)4.87248280
17phototransduction, visible light (GO:0007603)4.74283019
18retinol metabolic process (GO:0042572)4.73279492
19antigen processing and presentation of endogenous antigen (GO:0019883)4.71877086
20melanin biosynthetic process (GO:0042438)4.69545709
21negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.60492146
22retinal metabolic process (GO:0042574)4.54970720
23detection of light stimulus (GO:0009583)4.50265971
24retinoid metabolic process (GO:0001523)4.38192782
25detection of visible light (GO:0009584)4.35625671
26keratan sulfate catabolic process (GO:0042340)4.12248062
27melanin metabolic process (GO:0006582)4.11427494
28diterpenoid metabolic process (GO:0016101)4.10470129
29visual perception (GO:0007601)4.02120493
30polyol transport (GO:0015791)3.97045846
31sensory perception of light stimulus (GO:0050953)3.96884814
32modified amino acid transport (GO:0072337)3.90682175
33protein-chromophore linkage (GO:0018298)3.90230330
34quaternary ammonium group transport (GO:0015697)3.86585010
35secondary metabolite biosynthetic process (GO:0044550)3.76871462
36melanocyte differentiation (GO:0030318)3.76023615
37positive regulation of chemokine secretion (GO:0090197)3.74305322
38ketone body metabolic process (GO:1902224)3.69921811
39pigment cell differentiation (GO:0050931)3.58430066
40negative regulation of lipid storage (GO:0010888)3.57268236
41microglial cell activation (GO:0001774)3.55817627
42terpenoid metabolic process (GO:0006721)3.53679241
43negative chemotaxis (GO:0050919)3.52646379
44regulation of osteoblast proliferation (GO:0033688)3.50738383
45viral entry into host cell (GO:0046718)3.48876171
46sodium ion export (GO:0071436)3.48506726
47negative regulation of catenin import into nucleus (GO:0035414)3.47477104
48regulation of acrosome reaction (GO:0060046)3.45639632
49detection of external stimulus (GO:0009581)3.42531496
50camera-type eye morphogenesis (GO:0048593)3.36318921
51detection of abiotic stimulus (GO:0009582)3.34404269
52cellular sodium ion homeostasis (GO:0006883)3.32850273
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.29532791
54fat-soluble vitamin metabolic process (GO:0006775)3.29476643
55cell-cell junction maintenance (GO:0045217)3.26284210
56potassium ion import (GO:0010107)3.24635284
57ERK1 and ERK2 cascade (GO:0070371)3.24113475
58positive regulation of antigen processing and presentation (GO:0002579)3.20807351
59transepithelial transport (GO:0070633)3.19037712
60negative regulation of receptor-mediated endocytosis (GO:0048261)3.18632836
61smooth muscle tissue development (GO:0048745)3.17034329
62chondroitin sulfate catabolic process (GO:0030207)3.13105564
63glycerophospholipid catabolic process (GO:0046475)3.10489010
64locomotory exploration behavior (GO:0035641)3.08334245
65regulation of ARF protein signal transduction (GO:0032012)3.04922835
66cellular potassium ion homeostasis (GO:0030007)3.00454443
67regulation of extracellular matrix disassembly (GO:0010715)2.93287861
68face development (GO:0060324)2.92725430
69response to pheromone (GO:0019236)2.92719954
70regulation of rhodopsin mediated signaling pathway (GO:0022400)2.91668379
71retinoic acid metabolic process (GO:0042573)2.89712646
72primary alcohol metabolic process (GO:0034308)2.89019218
73nerve growth factor signaling pathway (GO:0038180)2.88125269
74synaptic vesicle maturation (GO:0016188)2.88080019
75isoprenoid metabolic process (GO:0006720)2.88000842
76bicarbonate transport (GO:0015701)2.82888111
77negative regulation of hormone biosynthetic process (GO:0032353)2.81377911
78negative regulation of hormone metabolic process (GO:0032351)2.81377911
79cellular component maintenance (GO:0043954)2.77764086
80mitochondrion distribution (GO:0048311)2.77569375
81regulation of chemokine secretion (GO:0090196)2.77158209
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.76104539
83inositol metabolic process (GO:0006020)2.74953531
84heterotypic cell-cell adhesion (GO:0034113)2.74459807
85cell junction maintenance (GO:0034331)2.73166949
86convergent extension (GO:0060026)2.73135118
87rhodopsin mediated signaling pathway (GO:0016056)2.71291256
88protein localization to endosome (GO:0036010)2.71232218
89endodermal cell differentiation (GO:0035987)2.70639091
90establishment of nucleus localization (GO:0040023)2.69941361
91response to auditory stimulus (GO:0010996)2.69694424
92sodium-independent organic anion transport (GO:0043252)2.68918626
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.67330037
94negative regulation of heart growth (GO:0061117)2.66573673
95negative regulation of cardiac muscle tissue growth (GO:0055022)2.66573673
96layer formation in cerebral cortex (GO:0021819)2.65715306
97negative regulation of granulocyte differentiation (GO:0030853)2.63813756
98detection of temperature stimulus (GO:0016048)2.62597469
99positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.59979753
100macroautophagy (GO:0016236)2.59072646
101negative regulation of JUN kinase activity (GO:0043508)2.58253089
102L-amino acid import (GO:0043092)2.58234536
103gamma-aminobutyric acid transport (GO:0015812)2.56678472
104embryonic eye morphogenesis (GO:0048048)2.56415231
105regulation of microtubule polymerization (GO:0031113)2.54657924
106L-serine transport (GO:0015825)2.54375666
107interkinetic nuclear migration (GO:0022027)2.53525774
108regulation of calcium ion-dependent exocytosis (GO:0017158)2.53455832
109peripheral nervous system axon ensheathment (GO:0032292)2.53188719
110myelination in peripheral nervous system (GO:0022011)2.53188719
111zinc ion transmembrane transport (GO:0071577)2.52625931
112regulation of non-canonical Wnt signaling pathway (GO:2000050)2.52620700
113entry into host cell (GO:0030260)2.51882092
114movement in environment of other organism involved in symbiotic interaction (GO:0052192)2.51882092
115entry into cell of other organism involved in symbiotic interaction (GO:0051806)2.51882092
116entry into host (GO:0044409)2.51882092
117entry into other organism involved in symbiotic interaction (GO:0051828)2.51882092
118movement in host environment (GO:0052126)2.51882092
119regulation of macrophage derived foam cell differentiation (GO:0010743)2.51007260
120glomerular visceral epithelial cell development (GO:0072015)2.50261358
121response to electrical stimulus (GO:0051602)2.49275841
122regulation of Cdc42 GTPase activity (GO:0043088)2.49115065
123regulation of cytokine production involved in inflammatory response (GO:1900015)2.48256394
124mannose metabolic process (GO:0006013)2.47691691
125regulation of receptor biosynthetic process (GO:0010869)2.46712155
126positive regulation of guanylate cyclase activity (GO:0031284)2.46517862
127modification by symbiont of host morphology or physiology (GO:0044003)2.44556857
128phagocytosis, recognition (GO:0006910)2.44075415
129regulation of ARF GTPase activity (GO:0032312)2.43964705
130cytoskeletal anchoring at plasma membrane (GO:0007016)2.42392373
131glycine transport (GO:0015816)2.42268148
132regulation of short-term neuronal synaptic plasticity (GO:0048172)2.42008276
133chemical homeostasis within a tissue (GO:0048875)2.40489586
134hyaluronan catabolic process (GO:0030214)2.39920458
135regulation of synapse structural plasticity (GO:0051823)2.39156961
136ear development (GO:0043583)2.38786011
137macrophage activation involved in immune response (GO:0002281)2.37969490
138neuroepithelial cell differentiation (GO:0060563)2.37863092
139stress fiber assembly (GO:0043149)2.36234032
140detection of light stimulus involved in visual perception (GO:0050908)2.35141534
141detection of light stimulus involved in sensory perception (GO:0050962)2.35141534
142positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.34642112
143negative regulation of lipid transport (GO:0032369)2.34460594
144positive regulation of pseudopodium assembly (GO:0031274)2.34267873
145tyrosine metabolic process (GO:0006570)2.33412909
146regulation of antigen processing and presentation (GO:0002577)2.33197146
147myotube differentiation (GO:0014902)2.33093968
148amino acid import (GO:0043090)2.33079012
149regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.31501201
150negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.31427586
151ovulation cycle (GO:0042698)2.31286608
152regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.29714951
153fusion of sperm to egg plasma membrane (GO:0007342)2.29649011
154proline transport (GO:0015824)2.28823806
155membrane repolarization (GO:0086009)2.28044052
156lung epithelium development (GO:0060428)2.25421754
157CDP-diacylglycerol biosynthetic process (GO:0016024)2.24242354
158positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.23347595
159alanine transport (GO:0032328)2.21698447
160adaptation of signaling pathway (GO:0023058)2.19515099
161neuromuscular process controlling balance (GO:0050885)2.19012218
162negative regulation of inclusion body assembly (GO:0090084)2.15783707
163serine transport (GO:0032329)2.14757746
164pathway-restricted SMAD protein phosphorylation (GO:0060389)2.14596475
165membrane repolarization during action potential (GO:0086011)2.11715529
166keratan sulfate metabolic process (GO:0042339)2.11560301
167CDP-diacylglycerol metabolic process (GO:0046341)2.09531532
168ruffle organization (GO:0031529)2.08844727
169cortical actin cytoskeleton organization (GO:0030866)2.08199051
170long-term memory (GO:0007616)2.05951445
171negative regulation of stress fiber assembly (GO:0051497)2.05922723
172synaptic vesicle endocytosis (GO:0048488)2.05441949
173peptidyl-threonine modification (GO:0018210)2.05413970
174positive regulation of Rap GTPase activity (GO:0032854)2.04462722
175glial cell migration (GO:0008347)2.04248203
176negative regulation of endocytosis (GO:0045806)2.03821870
177phototransduction (GO:0007602)2.03307685
178apoptotic cell clearance (GO:0043277)2.03091518
179vitamin A metabolic process (GO:0006776)11.9477057

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.29332973
2PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.66517084
3GATA1_22025678_ChIP-Seq_K562_Human2.49724132
4RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31753264
5AR_21572438_ChIP-Seq_LNCaP_Human2.16880981
6IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12800898
7RBPJ_22232070_ChIP-Seq_NCS_Mouse2.09383906
8GATA2_21666600_ChIP-Seq_HMVEC_Human1.94699156
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89517923
10SMAD_19615063_ChIP-ChIP_OVARY_Human1.88775906
11EZH2_18974828_ChIP-Seq_MESCs_Mouse1.87624918
12RNF2_18974828_ChIP-Seq_MESCs_Mouse1.87624918
13ESR2_21235772_ChIP-Seq_MCF-7_Human1.87058553
14NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.86379082
15CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.80644977
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.79169890
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.79060754
18DROSHA_22980978_ChIP-Seq_HELA_Human1.76747835
19ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71825753
20MTF2_20144788_ChIP-Seq_MESCs_Mouse1.69510295
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.65669714
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.63680911
23NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63629284
24NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63629284
25ZNF217_24962896_ChIP-Seq_MCF-7_Human1.62254129
26SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.62109722
27SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.59495241
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.59485402
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.58417546
30SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.57800848
31CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57508235
32JARID2_20064375_ChIP-Seq_MESCs_Mouse1.51942392
33* KDM2B_26808549_Chip-Seq_K562_Human1.48542497
34EZH2_22144423_ChIP-Seq_EOC_Human1.47660483
35WT1_25993318_ChIP-Seq_PODOCYTE_Human1.46279044
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45775832
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.44351396
38CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41881712
39FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.41549667
40TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.40236799
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.39077994
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37279770
43SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36745154
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.35614874
45RNF2_27304074_Chip-Seq_ESCs_Mouse1.32777469
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.29442077
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28851053
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.28289965
49ISL1_27105846_Chip-Seq_CPCs_Mouse1.27993179
50PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.26952871
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.26381536
52TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26348010
53DNAJC2_21179169_ChIP-ChIP_NT2_Human1.25698833
54EZH2_27294783_Chip-Seq_ESCs_Mouse1.25619247
55NR3C1_23031785_ChIP-Seq_PC12_Mouse1.24608293
56TP53_16413492_ChIP-PET_HCT116_Human1.23578032
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22041311
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.21314542
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.21279477
60EED_16625203_ChIP-ChIP_MESCs_Mouse1.20087721
61PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20053193
62TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19041305
63SUZ12_27294783_Chip-Seq_ESCs_Mouse1.16164569
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.15775905
65SALL4_18804426_ChIP-ChIP_XEN_Mouse1.15119849
66DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.14835786
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14755455
68VDR_24787735_ChIP-Seq_THP-1_Human1.14337291
69SMAD4_21741376_ChIP-Seq_HESCs_Human1.13802143
70SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13242496
71TAL1_26923725_Chip-Seq_HPCs_Mouse1.12670621
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.12207661
73ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12174453
74SMAD3_21741376_ChIP-Seq_HESCs_Human1.11036661
75GBX2_23144817_ChIP-Seq_PC3_Human1.10546946
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.09799197
77IGF1R_20145208_ChIP-Seq_DFB_Human1.09712719
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.09637853
79AHR_22903824_ChIP-Seq_MCF-7_Human1.09536587
80BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09519964
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08810960
82YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08456021
83NFIB_24661679_ChIP-Seq_LUNG_Mouse1.07750761
84TCF4_23295773_ChIP-Seq_U87_Human1.06863866
85LXR_22158963_ChIP-Seq_LIVER_Mouse1.06470748
86SMAD4_21799915_ChIP-Seq_A2780_Human1.05743142
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.05279820
88MITF_21258399_ChIP-Seq_MELANOMA_Human1.04811206
89REST_21632747_ChIP-Seq_MESCs_Mouse1.04778675
90SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.04750147
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03054395
92CJUN_26792858_Chip-Seq_BT549_Human1.00554706
93* KDM2B_26808549_Chip-Seq_JURKAT_Human1.00092519
94PIAS1_25552417_ChIP-Seq_VCAP_Human0.99167478
95FOXO3_23340844_ChIP-Seq_DLD1_Human0.98492530
96KDM2B_26808549_Chip-Seq_DND41_Human0.98421088
97* LXR_22292898_ChIP-Seq_THP-1_Human0.98403218
98GATA1_19941826_ChIP-Seq_K562_Human0.97953507
99PPAR_26484153_Chip-Seq_NCI-H1993_Human0.97689548
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97684310
101EZH2_27304074_Chip-Seq_ESCs_Mouse0.97540356
102SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97530761
103ERG_21242973_ChIP-ChIP_JURKAT_Human0.97510796
104RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96608329
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96431752
106ZFP281_18757296_ChIP-ChIP_E14_Mouse0.96133400
107ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95738866
108CTNNB1_20460455_ChIP-Seq_HCT116_Human0.94573516
109REST_18959480_ChIP-ChIP_MESCs_Mouse0.94551766
110TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.94338453
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.94123578
112SOX2_21211035_ChIP-Seq_LN229_Gbm0.93636923
113AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93163573
114TBX20_22328084_ChIP-Seq_HEART_Mouse0.92802495
115TBX20_22080862_ChIP-Seq_HEART_Mouse0.92802495
116AR_19668381_ChIP-Seq_PC3_Human0.92050037
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.91880508
118STAT3_23295773_ChIP-Seq_U87_Human0.91790400
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91177717
120FUS_26573619_Chip-Seq_HEK293_Human0.91026310
121NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89814665
122ZNF263_19887448_ChIP-Seq_K562_Human0.89458065
123VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88267572
124RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.88060975
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88012625
126SMAD3_21741376_ChIP-Seq_ESCs_Human0.87888835
127TP63_23658742_ChIP-Seq_EP156T_Human0.87775249
128TBX3_20139965_ChIP-Seq_MESCs_Mouse0.86946194
129RXR_22158963_ChIP-Seq_LIVER_Mouse0.86863308
130GATA2_19941826_ChIP-Seq_K562_Human0.86727944
131SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86532775
132TBX3_20139965_ChIP-Seq_ESCs_Mouse0.86497055
133ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86356450
134CLOCK_20551151_ChIP-Seq_293T_Human0.86267840
135MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.85937110
136FOXM1_26456572_ChIP-Seq_MCF-7_Human0.85931242
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.85266295
138TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.84279867
139SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.84221390
140RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.83450977
141SMC1_22415368_ChIP-Seq_MEFs_Mouse0.81807406
142ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81200442
143ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.81034836
144RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.80931912
145LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.80750562
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.80538888

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005257_abnormal_intraocular_pressure3.44273226
2MP0004019_abnormal_vitamin_homeostasis3.20890354
3MP0005058_abnormal_lysosome_morphology3.14675123
4MP0004859_abnormal_synaptic_plasticity3.07072617
5MP0005248_abnormal_Harderian_gland2.95200709
6MP0000372_irregular_coat_pigmentation2.92018609
7MP0008004_abnormal_stomach_pH2.55317560
8MP0002090_abnormal_vision2.43504030
9MP0001324_abnormal_eye_pigmentation2.38008300
10MP0005551_abnormal_eye_electrophysiolog2.36388162
11MP0008438_abnormal_cutaneous_collagen2.09173657
12MP0000465_gastrointestinal_hemorrhage2.03296415
13MP0003011_delayed_dark_adaptation10.6711435
14MP0005171_absent_coat_pigmentation1.99836192
15MP0004185_abnormal_adipocyte_glucose1.93892998
16MP0003172_abnormal_lysosome_physiology1.92237138
17MP0003690_abnormal_glial_cell1.88570649
18MP0005253_abnormal_eye_physiology1.83705227
19MP0005666_abnormal_adipose_tissue1.78301357
20MP0004885_abnormal_endolymph1.75296581
21MP0003300_gastrointestinal_ulcer1.68507817
22MP0003191_abnormal_cellular_cholesterol1.68197179
23MP0009384_cardiac_valve_regurgitation1.65633400
24MP0002638_abnormal_pupillary_reflex1.62817853
25MP0001958_emphysema1.59610055
26MP0003705_abnormal_hypodermis_morpholog1.59608856
27MP0003075_altered_response_to1.55641968
28MP0005408_hypopigmentation1.46922854
29MP0004858_abnormal_nervous_system1.46914203
30MP0005423_abnormal_somatic_nervous1.43735088
31MP0004270_analgesia1.43178835
32MP0009780_abnormal_chondrocyte_physiolo1.31715387
33MP0003635_abnormal_synaptic_transmissio1.31386528
34MP0000371_diluted_coat_color1.29975914
35MP0003303_peritoneal_inflammation1.29574585
36MP0001986_abnormal_taste_sensitivity1.29509679
37MP0000569_abnormal_digit_pigmentation1.29389533
38MP0001879_abnormal_lymphatic_vessel1.28165598
39MP0003045_fibrosis1.27602457
40MP0003136_yellow_coat_color1.27387645
41MP0003279_aneurysm1.27269415
42MP0006082_CNS_inflammation1.26770686
43MP0002653_abnormal_ependyma_morphology1.26322896
44MP0008961_abnormal_basal_metabolism1.25549087
45MP0005375_adipose_tissue_phenotype1.24098297
46MP0009840_abnormal_foam_cell1.22241793
47MP0005391_vision/eye_phenotype1.17520596
48MP0002877_abnormal_melanocyte_morpholog1.16723558
49MP0004130_abnormal_muscle_cell1.12165876
50MP0003633_abnormal_nervous_system1.11058202
51MP0003329_amyloid_beta_deposits1.06926033
52MP0005670_abnormal_white_adipose1.06209919
53MP0002928_abnormal_bile_duct1.05878149
54MP0002064_seizures1.04945792
55MP0002092_abnormal_eye_morphology1.04480755
56MP0004043_abnormal_pH_regulation1.04403400
57MP0005174_abnormal_tail_pigmentation1.00928704
58MP0005167_abnormal_blood-brain_barrier1.00449336
59MP0003646_muscle_fatigue0.99295485
60MP0003091_abnormal_cell_migration0.98993675
61MP0002089_abnormal_postnatal_growth/wei0.97782830
62MP0003634_abnormal_glial_cell0.97046434
63MP0004381_abnormal_hair_follicle0.96840855
64MP0003183_abnormal_peptide_metabolism0.95665410
65MP0002168_other_aberrant_phenotype0.94530877
66MP0001186_pigmentation_phenotype0.94018851
67MP0003566_abnormal_cell_adhesion0.93899244
68MP0005275_abnormal_skin_tensile0.92415041
69MP0002063_abnormal_learning/memory/cond0.91914053
70* MP0005195_abnormal_posterior_eye0.90521986
71MP0005187_abnormal_penis_morphology0.88351112
72MP0003283_abnormal_digestive_organ0.87832525
73MP0003631_nervous_system_phenotype0.85262918
74MP0005377_hearing/vestibular/ear_phenot0.84224871
75MP0003878_abnormal_ear_physiology0.84224871
76MP0004272_abnormal_basement_membrane0.81752833
77* MP0002229_neurodegeneration0.81153953
78MP0000003_abnormal_adipose_tissue0.80724760
79MP0001501_abnormal_sleep_pattern0.79754029
80MP0008569_lethality_at_weaning0.78474176
81MP0006072_abnormal_retinal_apoptosis0.77477881
82MP0005197_abnormal_uvea_morphology0.76749914
83MP0002095_abnormal_skin_pigmentation0.75495241
84MP0005075_abnormal_melanosome_morpholog0.73285693
85MP0001486_abnormal_startle_reflex0.73031586
86MP0000015_abnormal_ear_pigmentation0.71876845
87MP0003252_abnormal_bile_duct0.71104533
88MP0001299_abnormal_eye_distance/0.70748642
89MP0010234_abnormal_vibrissa_follicle0.70465971
90MP0002075_abnormal_coat/hair_pigmentati0.70005635
91MP0005166_decreased_susceptibility_to0.67939067
92MP0004484_altered_response_of0.67837735
93MP0002998_abnormal_bone_remodeling0.67486758
94MP0004145_abnormal_muscle_electrophysio0.67178058
95MP0000604_amyloidosis0.65136222
96MP0001177_atelectasis0.65127537
97MP0003632_abnormal_nervous_system0.64125041
98MP0000462_abnormal_digestive_system0.63896333
99MP0000920_abnormal_myelination0.62421427
100MP0002736_abnormal_nociception_after0.61423011
101MP0000534_abnormal_ureter_morphology0.61341848
102MP0005503_abnormal_tendon_morphology0.59153914
103MP0003950_abnormal_plasma_membrane0.59131258
104MP0010030_abnormal_orbit_morphology0.57950781
105MP0002102_abnormal_ear_morphology0.57784745
106MP0001915_intracranial_hemorrhage0.57434183
107MP0002734_abnormal_mechanical_nocicepti0.57407867
108MP0000685_abnormal_immune_system0.56827389
109* MP0002882_abnormal_neuron_morphology0.56689177
110MP0004510_myositis0.55681604
111MP0008874_decreased_physiological_sensi0.55068732
112MP0002572_abnormal_emotion/affect_behav0.54983244
113MP0001502_abnormal_circadian_rhythm0.54785814
114MP0003879_abnormal_hair_cell0.54764781
115MP0000566_synostosis0.54497310
116MP0009745_abnormal_behavioral_response0.54172929
117MP0010368_abnormal_lymphatic_system0.53429670
118MP0002557_abnormal_social/conspecific_i0.53236273
119MP0002933_joint_inflammation0.52516547
120MP0004233_abnormal_muscle_weight0.52051129
121MP0008775_abnormal_heart_ventricle0.51317424
122MP0004084_abnormal_cardiac_muscle0.48346496
123MP0000751_myopathy0.46753845
124MP0005193_abnormal_anterior_eye0.45460961
125MP0001661_extended_life_span0.45091770
126* MP0002752_abnormal_somatic_nervous0.44651288
127MP0010386_abnormal_urinary_bladder0.42786438
128MP0000747_muscle_weakness0.42050908
129MP0003385_abnormal_body_wall0.40611069
130MP0005220_abnormal_exocrine_pancreas0.40398621
131MP0004036_abnormal_muscle_relaxation0.37273282
132MP0002938_white_spotting0.37037358
133MP0005409_darkened_coat_color0.36999305
134MP0002971_abnormal_brown_adipose0.34782032
135MP0010352_gastrointestinal_tract_polyps0.33913438
136MP0005023_abnormal_wound_healing0.33293445
137MP0000383_abnormal_hair_follicle0.33206647
138MP0005508_abnormal_skeleton_morphology0.32879846
139MP0006138_congestive_heart_failure0.32834876
140MP0005623_abnormal_meninges_morphology0.31390482
141MP0000749_muscle_degeneration0.30394899
142MP0002295_abnormal_pulmonary_circulatio0.29057239
143MP0000367_abnormal_coat/_hair0.28432724
144MP0000013_abnormal_adipose_tissue0.28031905
145MP0002233_abnormal_nose_morphology0.27708782
146MP0003828_pulmonary_edema0.27058773
147MP0001485_abnormal_pinna_reflex0.25872164

Predicted human phenotypes

RankGene SetZ-score
1Decreased electroretinogram (ERG) amplitude (HP:0000654)8.16432613
2Ulnar claw (HP:0001178)6.92275855
3* Choroideremia (HP:0001139)5.55209531
4Segmental peripheral demyelination/remyelination (HP:0003481)5.27572780
5Vertebral compression fractures (HP:0002953)5.26569120
6Termporal pattern (HP:0011008)5.09811298
7Insidious onset (HP:0003587)5.09811298
8Peripheral hypomyelination (HP:0007182)4.84036895
9Upper limb muscle weakness (HP:0003484)4.79721734
10Arterial tortuosity (HP:0005116)4.76297500
11Abnormal pupillary function (HP:0007686)4.63294668
12Complement deficiency (HP:0004431)4.63260968
13Congenital stationary night blindness (HP:0007642)4.55296616
14Vascular tortuosity (HP:0004948)4.48271398
15Biconcave vertebral bodies (HP:0004586)4.33647117
16Systemic lupus erythematosus (HP:0002725)4.27594119
17Attenuation of retinal blood vessels (HP:0007843)4.24625572
18Mutism (HP:0002300)4.24156525
19Cerebral aneurysm (HP:0004944)4.16852455
20Beaking of vertebral bodies (HP:0004568)4.16792344
21Decreased central vision (HP:0007663)4.16733332
22* Hypopigmentation of the fundus (HP:0007894)3.96808525
23Aortic aneurysm (HP:0004942)3.94527924
24Dyschromatopsia (HP:0007641)3.94374066
25Action tremor (HP:0002345)3.88889252
26Abnormality of liposaccharide metabolism (HP:0010968)3.79948295
27Abnormality of glycosphingolipid metabolism (HP:0004343)3.79948295
28Abnormality of glycolipid metabolism (HP:0010969)3.79948295
29Nonprogressive disorder (HP:0003680)3.47460837
30Glomerulonephritis (HP:0000099)3.38323428
31Aortic dissection (HP:0002647)3.31697805
32Bilateral sensorineural hearing impairment (HP:0008619)3.23150516
33Dysostosis multiplex (HP:0000943)3.22996944
34Increased corneal curvature (HP:0100692)3.11679636
35Keratoconus (HP:0000563)3.11679636
36Scotoma (HP:0000575)3.11336121
37Abnormality of complement system (HP:0005339)3.05268796
38Hypoplasia of the iris (HP:0007676)3.03943526
39Intention tremor (HP:0002080)3.03913455
40Neurofibrillary tangles (HP:0002185)3.01186634
41Orthostatic hypotension (HP:0001278)3.00873331
42Progressive sensorineural hearing impairment (HP:0000408)2.98086339
43Abolished electroretinogram (ERG) (HP:0000550)2.96970738
44Subcapsular cataract (HP:0000523)2.93966857
45White forelock (HP:0002211)2.93275512
46Retinal atrophy (HP:0001105)2.90365321
47Aplasia/Hypoplasia of the fovea (HP:0008060)2.87777474
48Hypoplasia of the fovea (HP:0007750)2.87777474
49Impaired proprioception (HP:0010831)2.87438854
50Postural tremor (HP:0002174)2.70643862
51Photophobia (HP:0000613)2.69703782
52Cardiovascular calcification (HP:0011915)2.67116861
53Hand muscle atrophy (HP:0009130)2.65817426
54Shallow orbits (HP:0000586)2.65224680
55Vascular calcification (HP:0004934)2.65122160
56* Bony spicule pigmentary retinopathy (HP:0007737)2.64039413
57Cerebral inclusion bodies (HP:0100314)2.62176198
58Neuronal loss in central nervous system (HP:0002529)2.61198637
59Striae distensae (HP:0001065)2.59265308
60* Abnormality of the fovea (HP:0000493)2.56306342
61Patchy hypopigmentation of hair (HP:0011365)2.55090844
62Subacute progressive viral hepatitis (HP:0006572)2.51630091
63Cone-rod dystrophy (HP:0000548)2.47717036
64Pendular nystagmus (HP:0012043)2.46735388
65Steppage gait (HP:0003376)2.45720014
66Blue irides (HP:0000635)2.45676060
67Ocular albinism (HP:0001107)2.44606413
68Myokymia (HP:0002411)2.43886754
69Distal upper limb amyotrophy (HP:0007149)2.42813475
70Upper limb amyotrophy (HP:0009129)2.42813475
71Abnormality of polysaccharide metabolism (HP:0011012)2.42704073
72Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42704073
73Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42704073
74Spondylolisthesis (HP:0003302)2.42199969
75Hemorrhage of the eye (HP:0011885)2.41846171
76Mucopolysacchariduria (HP:0008155)2.40978428
77Urinary glycosaminoglycan excretion (HP:0003541)2.40978428
78Hemiparesis (HP:0001269)2.39613846
79Increased cerebral lipofuscin (HP:0011813)2.39380769
80Increased CSF protein (HP:0002922)2.38645816
81Supranuclear gaze palsy (HP:0000605)2.38109793
82Hepatoblastoma (HP:0002884)2.38051531
83Mitral valve prolapse (HP:0001634)2.37739223
84Constricted visual fields (HP:0001133)2.37278799
85Disproportionate tall stature (HP:0001519)2.36597106
86Ventricular fibrillation (HP:0001663)2.36037562
87Postural instability (HP:0002172)2.35660197
88Macular degeneration (HP:0000608)2.32726345
89Obstructive sleep apnea (HP:0002870)2.32587001
90Hemiplegia (HP:0002301)2.28578708
91Severe visual impairment (HP:0001141)2.27134839
92Aplasia/Hypoplasia of the macula (HP:0008059)2.26161221
93Aplasia/Hypoplasia affecting the retina (HP:0008061)2.25892598
94Central scotoma (HP:0000603)2.20624857
95Annular pancreas (HP:0001734)2.19799706
96Cardiomegaly (HP:0001640)2.19178624
97Onion bulb formation (HP:0003383)2.18534421
98Nephritis (HP:0000123)2.18159708
99Hammertoe (HP:0001765)2.11999027
100Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.11476639
101Abnormality of macular pigmentation (HP:0008002)2.10377654
102Foot dorsiflexor weakness (HP:0009027)2.08086954
103Aneurysm (HP:0002617)2.07698196
104Progressive neurologic deterioration (HP:0002344)2.07356799
105Coxa vara (HP:0002812)2.05241530
106Decreased motor nerve conduction velocity (HP:0003431)2.04326603
107Arnold-Chiari malformation (HP:0002308)2.03880086
108Iris hypopigmentation (HP:0007730)2.03490257
109Protrusio acetabuli (HP:0003179)1.99017561
110Peripheral demyelination (HP:0011096)1.97422371
111Polar cataract (HP:0010696)1.96940631
112Facial shape deformation (HP:0011334)1.96803139
113Potter facies (HP:0002009)1.96803139
114Hematochezia (HP:0002573)1.95998112
115Aplasia involving bones of the upper limbs (HP:0009823)1.95364351
116Aplasia of the phalanges of the hand (HP:0009802)1.95364351
117Aplasia involving bones of the extremities (HP:0009825)1.95364351
118Epidermoid cyst (HP:0200040)1.92392967
119Hyperphosphatemia (HP:0002905)1.87004578
120Abnormality of the foot musculature (HP:0001436)1.86281652
121Amyloidosis (HP:0011034)1.85589884
122Clumsiness (HP:0002312)1.84931702
123Absent frontal sinuses (HP:0002688)1.84720082
124Urethral obstruction (HP:0000796)1.84429067
125Increased neuronal autofluorescent lipopigment (HP:0002074)1.84174854
126Stereotypic behavior (HP:0000733)1.83975553
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.83234955
128Urinary incontinence (HP:0000020)1.81695374
129Soft skin (HP:0000977)1.78406630
130Erectile abnormalities (HP:0100639)1.76713031
131Cervical subluxation (HP:0003308)1.75470957
132Achilles tendon contracture (HP:0001771)1.74657322
133Type II diabetes mellitus (HP:0005978)1.73224654
134Asymmetric septal hypertrophy (HP:0001670)1.72296732
135Dementia (HP:0000726)1.71520068
136Dilatation of the ascending aorta (HP:0005111)1.70076454
137Abnormality of the acetabulum (HP:0003170)1.68071614
138Horizontal nystagmus (HP:0000666)1.67563443
139Diplopia (HP:0000651)1.66603857
140Abnormality of binocular vision (HP:0011514)1.66603857
141Thyroiditis (HP:0100646)1.66434470
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.66203564
143Lower limb asymmetry (HP:0100559)1.65698523
144Zonular cataract (HP:0010920)1.65696156
145Camptodactyly of toe (HP:0001836)1.64215087
146Bell-shaped thorax (HP:0001591)1.63915965
147Pigmentary retinal degeneration (HP:0001146)1.63238957
148Facial diplegia (HP:0001349)1.61778210
149Premature graying of hair (HP:0002216)1.61525522
150Interstitial pulmonary disease (HP:0006530)1.61285611
151Abnormality of the pupil (HP:0000615)1.59917933
152Generalized hypopigmentation (HP:0007513)1.59467906
153Osteolytic defects of the phalanges of the hand (HP:0009771)1.59415290
154Osteolytic defects of the hand bones (HP:0009699)1.59415290
155Progressive hearing impairment (HP:0001730)1.56897024
156Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.56816706
157Persistence of primary teeth (HP:0006335)1.55903834
158Congenital sensorineural hearing impairment (HP:0008527)1.52924201
159Syringomyelia (HP:0003396)1.52414241
160Spinal cord lesions (HP:0100561)1.52414241
161Retinitis pigmentosa (HP:0000510)1.52006490
162Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.46709787
163Flared iliac wings (HP:0002869)1.46095909

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR24.35742172
2GRK13.42011559
3MET3.39033148
4MAPK152.95975648
5MAP3K92.74070601
6KSR22.52641229
7TRPM72.44568995
8TRIB32.41616931
9PRKD32.33882126
10LATS12.15308180
11LATS22.13263581
12EEF2K2.07639498
13BLK2.03804776
14PKN22.03403837
15MYLK1.97198437
16STK241.92460902
17CAMK1D1.87421879
18PAK61.83593502
19MARK31.82102054
20TGFBR11.77225783
21CAMK1G1.73230747
22MAP3K61.65437957
23CSF1R1.62898587
24RIPK11.57853221
25RET1.53852216
26TIE11.52750032
27DMPK1.44082127
28LMTK21.41572192
29CAMKK11.38995994
30STK381.35329952
31PTK61.33598919
32BRD41.33108515
33TEC1.32475888
34TAOK11.30501100
35MUSK1.29081894
36SIK11.27028262
37ERN11.26308308
38NTRK21.20814318
39NEK91.11825992
40PAK41.11629706
41WNK41.08214981
42MOS1.07328172
43TYRO31.07292492
44GRK71.07015866
45TAOK31.06738193
46EPHA31.06301856
47PAK21.05720313
48KSR11.05307154
49PDGFRA1.04931504
50TSSK61.04377026
51EPHB21.03992572
52CSNK1A1L1.03801060
53MAP3K41.03402027
54PDK11.02876232
55ABL21.01653072
56DDR21.01539271
57FGFR21.01106003
58WNK11.00609243
59OBSCN0.98699075
60EPHA40.97582084
61MAP3K130.95141681
62DYRK1A0.94960292
63MINK10.94405787
64PRKCH0.94323492
65PHKG20.90967077
66PHKG10.90967077
67JAK20.90878405
68PDPK10.88869390
69NTRK10.88116967
70NTRK30.87448419
71PDK20.87324193
72ERBB40.85669859
73JAK10.85113315
74MAPK120.84971872
75RIPK40.84223464
76STK390.83943421
77CSNK1G20.83240435
78MAPK70.82688869
79MAP3K20.82084314
80STK100.79518337
81CSNK1G10.79043875
82MAP2K40.78628963
83MAPKAPK50.75680002
84SGK30.73413334
85FRK0.71290824
86MELK0.69931381
87EPHB10.69174415
88CSNK1G30.68223820
89DYRK1B0.66708574
90STK30.65521152
91STK38L0.63555904
92PTK2B0.63545055
93SGK4940.63197064
94SGK2230.63197064
95BMX0.62984006
96TYK20.62823651
97CAMK40.62669759
98CDK50.61896307
99STK110.61403465
100RAF10.61129459
101MARK20.59238206
102BTK0.58036475
103UHMK10.57596244
104GRK50.57420707
105SGK20.56641207
106PDGFRB0.56153782
107CCNB10.56089092
108CAMKK20.55971098
109PRKD10.55788031
110SYK0.55328034
111ICK0.53909533
112PINK10.52973981
113ADRBK10.52351657
114PRKAA10.51725435
115PRKCZ0.50446807
116PAK30.48410092
117PRKCE0.47688512
118PRKD20.47437639
119MAPKAPK30.47087980
120MST1R0.46660796
121MARK10.46389657
122ROCK20.45941956
123CSK0.45588423
124CAMK10.44118683
125PRKAA20.43836802
126GSK3A0.43406528
127INSR0.43257385
128CDK120.42686574
129OXSR10.42436666
130TTN0.42290268
131MAP3K70.42045986
132TTK0.41968307
133FER0.41384498
134TESK20.41191706
135HCK0.39880612
136SGK10.39791389
137MAPK130.37505921
138PTK20.37132967
139PKN10.36742910
140SIK20.36646873
141MTOR0.36560377
142CSNK1D0.34763452
143CDK90.34221094
144AKT20.33917005
145PRKCD0.32049637
146ABL10.30808432
147PRKACA0.30003962
148MAP2K70.29695106
149FES0.28913932
150DYRK30.28475980
151MAPK30.24412241
152IRAK10.23969456
153ROCK10.23456580

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.18310045
2Histidine metabolism_Homo sapiens_hsa003403.13111942
3Phenylalanine metabolism_Homo sapiens_hsa003603.01319536
4Other glycan degradation_Homo sapiens_hsa005112.27892807
5Complement and coagulation cascades_Homo sapiens_hsa046102.24876570
6beta-Alanine metabolism_Homo sapiens_hsa004102.22378911
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.21806405
8Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13175571
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.08484762
10Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.86254426
11Salivary secretion_Homo sapiens_hsa049701.82752508
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.69324414
13Circadian rhythm_Homo sapiens_hsa047101.66690316
14Lysosome_Homo sapiens_hsa041421.57115591
15Gastric acid secretion_Homo sapiens_hsa049711.56901208
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51521036
17Prion diseases_Homo sapiens_hsa050201.51257615
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.44826662
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43094439
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.37091042
21Retinol metabolism_Homo sapiens_hsa008301.34537290
22Estrogen signaling pathway_Homo sapiens_hsa049151.29214350
23Staphylococcus aureus infection_Homo sapiens_hsa051501.27599396
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.27401897
25GnRH signaling pathway_Homo sapiens_hsa049121.24481986
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.23510984
27Olfactory transduction_Homo sapiens_hsa047401.21712401
28Long-term potentiation_Homo sapiens_hsa047201.21514316
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.19306794
30Bile secretion_Homo sapiens_hsa049761.16271190
31Renin secretion_Homo sapiens_hsa049241.14970028
32Glioma_Homo sapiens_hsa052141.14029969
33Circadian entrainment_Homo sapiens_hsa047131.13826594
34Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10019948
35Glutamatergic synapse_Homo sapiens_hsa047241.08163768
36Dorso-ventral axis formation_Homo sapiens_hsa043201.07252118
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07109127
38Wnt signaling pathway_Homo sapiens_hsa043101.06152223
39ABC transporters_Homo sapiens_hsa020101.05651311
40Phosphatidylinositol signaling system_Homo sapiens_hsa040701.03533695
41cAMP signaling pathway_Homo sapiens_hsa040241.02652331
42Melanoma_Homo sapiens_hsa052181.02378314
43Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.00691789
44Synaptic vesicle cycle_Homo sapiens_hsa047210.97066859
45Renal cell carcinoma_Homo sapiens_hsa052110.95811486
46Small cell lung cancer_Homo sapiens_hsa052220.95178551
47mTOR signaling pathway_Homo sapiens_hsa041500.94992942
48Basal cell carcinoma_Homo sapiens_hsa052170.94928023
49Melanogenesis_Homo sapiens_hsa049160.94642038
50Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94008461
51Tyrosine metabolism_Homo sapiens_hsa003500.93861988
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92448709
53Choline metabolism in cancer_Homo sapiens_hsa052310.90747786
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.90685769
55GABAergic synapse_Homo sapiens_hsa047270.90392910
56Amphetamine addiction_Homo sapiens_hsa050310.89331728
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.88665955
58Pancreatic cancer_Homo sapiens_hsa052120.88264484
59Thyroid hormone synthesis_Homo sapiens_hsa049180.87966500
60Type II diabetes mellitus_Homo sapiens_hsa049300.87937334
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.87756509
62Oxytocin signaling pathway_Homo sapiens_hsa049210.86939114
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.86577166
64Regulation of actin cytoskeleton_Homo sapiens_hsa048100.85368454
65Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85086228
66Vitamin digestion and absorption_Homo sapiens_hsa049770.85081441
67Mineral absorption_Homo sapiens_hsa049780.84036869
68Phototransduction_Homo sapiens_hsa047440.83458451
69Malaria_Homo sapiens_hsa051440.82591250
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.81680965
71Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81276010
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.80288638
73Sphingolipid metabolism_Homo sapiens_hsa006000.80176374
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.79895288
75Endocytosis_Homo sapiens_hsa041440.79544663
76Osteoclast differentiation_Homo sapiens_hsa043800.77704322
77Cholinergic synapse_Homo sapiens_hsa047250.77563357
78Thyroid hormone signaling pathway_Homo sapiens_hsa049190.75583969
79Dilated cardiomyopathy_Homo sapiens_hsa054140.74987531
80Insulin secretion_Homo sapiens_hsa049110.72897664
81Colorectal cancer_Homo sapiens_hsa052100.72760223
82Focal adhesion_Homo sapiens_hsa045100.72126718
83Ether lipid metabolism_Homo sapiens_hsa005650.72121699
84Long-term depression_Homo sapiens_hsa047300.71508180
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.70560219
86Cocaine addiction_Homo sapiens_hsa050300.69523090
87Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.69066513
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68252139
89Calcium signaling pathway_Homo sapiens_hsa040200.68073867
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67953571
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67702480
92VEGF signaling pathway_Homo sapiens_hsa043700.66485372
93Inositol phosphate metabolism_Homo sapiens_hsa005620.66296264
94TGF-beta signaling pathway_Homo sapiens_hsa043500.65886133
95Rap1 signaling pathway_Homo sapiens_hsa040150.64911345
96Ovarian steroidogenesis_Homo sapiens_hsa049130.64680145
97Gap junction_Homo sapiens_hsa045400.63348133
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62991872
99AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62397475
100Morphine addiction_Homo sapiens_hsa050320.62370597
101Non-small cell lung cancer_Homo sapiens_hsa052230.62070384
102Dopaminergic synapse_Homo sapiens_hsa047280.61889565
103Arachidonic acid metabolism_Homo sapiens_hsa005900.60942889
104Tryptophan metabolism_Homo sapiens_hsa003800.60587604
105ErbB signaling pathway_Homo sapiens_hsa040120.60018185
106Pathways in cancer_Homo sapiens_hsa052000.59515504
107Chronic myeloid leukemia_Homo sapiens_hsa052200.59085306
108Glycerophospholipid metabolism_Homo sapiens_hsa005640.58862544
109ECM-receptor interaction_Homo sapiens_hsa045120.57846952
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57633467
111Platelet activation_Homo sapiens_hsa046110.57315451
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57202878
113Adherens junction_Homo sapiens_hsa045200.57161787
114Fatty acid metabolism_Homo sapiens_hsa012120.57154669
115Axon guidance_Homo sapiens_hsa043600.57120338
116Proteoglycans in cancer_Homo sapiens_hsa052050.57074523
117Nicotine addiction_Homo sapiens_hsa050330.56779321
118Pancreatic secretion_Homo sapiens_hsa049720.55476219
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.54500351
120PPAR signaling pathway_Homo sapiens_hsa033200.53698213
121Ras signaling pathway_Homo sapiens_hsa040140.53622448
122Hippo signaling pathway_Homo sapiens_hsa043900.53073597
123Cyanoamino acid metabolism_Homo sapiens_hsa004600.52933163
124Fatty acid biosynthesis_Homo sapiens_hsa000610.52907097
125Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.52746610
126Pertussis_Homo sapiens_hsa051330.52680562
127Steroid hormone biosynthesis_Homo sapiens_hsa001400.52616559
128Endometrial cancer_Homo sapiens_hsa052130.52464630
129Glycerolipid metabolism_Homo sapiens_hsa005610.52084470
130Phagosome_Homo sapiens_hsa041450.50078783
1312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49085167
132FoxO signaling pathway_Homo sapiens_hsa040680.47651996
133Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46276349
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.46121607
135Tight junction_Homo sapiens_hsa045300.45107462
136MicroRNAs in cancer_Homo sapiens_hsa052060.42180087
137Fatty acid degradation_Homo sapiens_hsa000710.40876116
138Adipocytokine signaling pathway_Homo sapiens_hsa049200.39651674
139Arginine biosynthesis_Homo sapiens_hsa002200.38918696
140Lysine degradation_Homo sapiens_hsa003100.37402584
141Taste transduction_Homo sapiens_hsa047420.36654229
142Chemical carcinogenesis_Homo sapiens_hsa052040.34447748
143Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33624245
144Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30593245
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29858366

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