MFSD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.70422399
2positive regulation of mast cell activation (GO:0033005)4.30386840
3positive regulation of mast cell degranulation (GO:0043306)4.00248082
4positive regulation of mast cell activation involved in immune response (GO:0033008)4.00248082
5cellular response to thyroid hormone stimulus (GO:0097067)3.99803867
6positive regulation of gamma-delta T cell activation (GO:0046645)3.97600961
7regulation of mast cell degranulation (GO:0043304)3.91259123
8negative regulation of interleukin-12 production (GO:0032695)3.88924577
9glycosphingolipid catabolic process (GO:0046479)3.80203380
10regulation of interferon-beta biosynthetic process (GO:0045357)3.73866482
11regulation of mast cell activation involved in immune response (GO:0033006)3.68117416
12positive regulation by symbiont of host defense response (GO:0052509)3.64062113
13modulation by symbiont of host defense response (GO:0052031)3.64062113
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.64062113
15modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.64062113
16positive regulation by organism of defense response of other organism involved in symbiotic interact3.64062113
17modulation by symbiont of host immune response (GO:0052553)3.64062113
18positive regulation of leukocyte degranulation (GO:0043302)3.63377454
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.62929950
20regulation of mast cell activation (GO:0033003)3.59359272
21neutrophil activation (GO:0042119)3.56465163
22granulocyte activation (GO:0036230)3.54497617
23detection of other organism (GO:0098543)3.53299759
24positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.47754322
25cysteine metabolic process (GO:0006534)3.47448385
26cellular extravasation (GO:0045123)3.47133471
27glycolipid catabolic process (GO:0019377)3.47051554
28regulation of leukocyte degranulation (GO:0043300)3.42762007
29detection of molecule of bacterial origin (GO:0032490)3.38919162
30sulfur amino acid catabolic process (GO:0000098)3.38887354
31myeloid cell activation involved in immune response (GO:0002275)3.38012044
32peptidyl-glutamic acid carboxylation (GO:0017187)3.36575890
33protein carboxylation (GO:0018214)3.36575890
34oligosaccharide catabolic process (GO:0009313)3.35456307
35regulation of myeloid leukocyte mediated immunity (GO:0002886)3.35262904
36erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30964178
37L-phenylalanine metabolic process (GO:0006558)3.30964178
38positive regulation of interferon-alpha production (GO:0032727)3.29541861
39urate metabolic process (GO:0046415)3.28399640
40low-density lipoprotein particle clearance (GO:0034383)3.27960992
41glyoxylate metabolic process (GO:0046487)3.23065988
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.20301113
43L-phenylalanine catabolic process (GO:0006559)3.19203378
44erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.19203378
45microglial cell activation (GO:0001774)3.17244373
46detection of external biotic stimulus (GO:0098581)3.17089867
47detection of bacterium (GO:0016045)3.15335476
48positive regulation of cellular amide metabolic process (GO:0034250)3.12424860
49plasma lipoprotein particle clearance (GO:0034381)3.12336948
50regulation of platelet activation (GO:0010543)3.11591649
51B cell mediated immunity (GO:0019724)3.11141690
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.10283514
53glycine metabolic process (GO:0006544)3.09922233
54regulation of interferon-alpha production (GO:0032647)3.09918079
55fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09457297
56aromatic amino acid family catabolic process (GO:0009074)3.08078844
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06364773
58mature B cell differentiation involved in immune response (GO:0002313)3.06164043
59negative regulation of erythrocyte differentiation (GO:0045647)3.04606137
60alpha-linolenic acid metabolic process (GO:0036109)3.03963224
61homocysteine metabolic process (GO:0050667)3.03930901
62regulation of cholesterol storage (GO:0010885)3.03268157
63positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01345620
64negative regulation of interleukin-17 production (GO:0032700)3.01131064
65positive regulation of monocyte chemotaxis (GO:0090026)3.00983367
66ceramide catabolic process (GO:0046514)3.00947934
67serine family amino acid catabolic process (GO:0009071)2.99993357
68regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.98899981
69macrophage activation (GO:0042116)2.98276813
70urea cycle (GO:0000050)2.97424875
71urea metabolic process (GO:0019627)2.97424875
72folic acid metabolic process (GO:0046655)2.95124971
73lysine catabolic process (GO:0006554)2.94371642
74lysine metabolic process (GO:0006553)2.94371642
75serine family amino acid biosynthetic process (GO:0009070)2.94256571
76indole-containing compound catabolic process (GO:0042436)2.93859228
77indolalkylamine catabolic process (GO:0046218)2.93859228
78tryptophan catabolic process (GO:0006569)2.93859228
79negative regulation of fibrinolysis (GO:0051918)2.93851775
80serine family amino acid metabolic process (GO:0009069)2.93379545
81tryptophan metabolic process (GO:0006568)2.92473260
82peptide catabolic process (GO:0043171)2.90983925
83phagocytosis, engulfment (GO:0006911)2.90764376
84interferon-gamma-mediated signaling pathway (GO:0060333)2.90385319
85pinocytosis (GO:0006907)2.89977836
86positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89522055
87lipoxygenase pathway (GO:0019372)2.89491214
88kynurenine metabolic process (GO:0070189)2.88726088
89positive regulation of antigen processing and presentation (GO:0002579)2.88220084
90regulation of hypersensitivity (GO:0002883)2.88151587
91amino-acid betaine metabolic process (GO:0006577)2.87955624
92folic acid transport (GO:0015884)2.85982386
93positive regulation of B cell differentiation (GO:0045579)2.85790711
94positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.84242650
95regulation of protein activation cascade (GO:2000257)2.82336345
96negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.82139730
97negative regulation of cell killing (GO:0031342)2.82139730
98regulation of platelet aggregation (GO:0090330)2.80674007
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80180965
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.80180965
101complement activation, alternative pathway (GO:0006957)2.79062333
102regulation of macrophage chemotaxis (GO:0010758)2.77135334
103amino sugar catabolic process (GO:0046348)2.76537271
104regulation of T-helper 2 cell differentiation (GO:0045628)2.76526479
105Arp2/3 complex-mediated actin nucleation (GO:0034314)2.76493233
106regulation of antigen processing and presentation (GO:0002577)2.76056842
107detection of biotic stimulus (GO:0009595)2.73899077
108bile acid biosynthetic process (GO:0006699)2.73764807
109regulation of complement activation (GO:0030449)2.73367764
110regulation of mononuclear cell migration (GO:0071675)2.73095103
111positive regulation of tumor necrosis factor production (GO:0032760)2.69862935
112nitrogen cycle metabolic process (GO:0071941)2.69200371
113regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.68197309
114aldehyde catabolic process (GO:0046185)2.67407795
115cell adhesion mediated by integrin (GO:0033627)2.65810172
116regulation of macrophage cytokine production (GO:0010935)2.65678945
117drug transport (GO:0015893)2.65199569
118regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.63434428
119regulation of B cell receptor signaling pathway (GO:0050855)2.62652859
120regulation of regulated secretory pathway (GO:1903305)2.62611762
121regulation of gamma-delta T cell activation (GO:0046643)2.62453560
122positive regulation of macrophage differentiation (GO:0045651)2.62182177
123positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.61452984
124response to muramyl dipeptide (GO:0032495)2.61096995
125positive regulation of type 2 immune response (GO:0002830)2.60900903
126fibrinolysis (GO:0042730)2.60794442
127thrombin receptor signaling pathway (GO:0070493)2.60578723
128immunoglobulin mediated immune response (GO:0016064)2.60450894
129apoptotic cell clearance (GO:0043277)2.59499057
130negative regulation of nitric oxide biosynthetic process (GO:0045019)2.59354888
131response to host immune response (GO:0052572)2.58870964
132response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.58870964
133leukocyte degranulation (GO:0043299)2.58737750
134positive regulation of regulated secretory pathway (GO:1903307)2.58623822
135regulation of monocyte chemotaxis (GO:0090025)2.58459979
136drug transmembrane transport (GO:0006855)2.57522876
137respiratory burst (GO:0045730)2.56851720
138regulation of fibrinolysis (GO:0051917)2.56667930
139T-helper 1 type immune response (GO:0042088)2.54515055
140positive regulation of macrophage cytokine production (GO:0060907)2.53749618
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.53728850
142barbed-end actin filament capping (GO:0051016)2.53281157
143cellular modified amino acid catabolic process (GO:0042219)2.52609155
144regulation of cholesterol homeostasis (GO:2000188)2.52024527
145negative regulation of cholesterol transport (GO:0032375)2.52014528
146negative regulation of sterol transport (GO:0032372)2.52014528
147positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.51758278
148high-density lipoprotein particle remodeling (GO:0034375)2.50103889
149positive regulation of toll-like receptor signaling pathway (GO:0034123)2.49965087
150positive regulation of interferon-beta production (GO:0032728)2.49581620
151myeloid leukocyte activation (GO:0002274)2.49088397
152macrophage activation involved in immune response (GO:0002281)2.48878794
153angiogenesis involved in wound healing (GO:0060055)2.47084026
154regulation of T-helper 1 cell differentiation (GO:0045625)2.46346685
155positive regulation of interleukin-6 production (GO:0032755)2.46123455
156regulation of interleukin-17 production (GO:0032660)2.46069445
157lipoprotein metabolic process (GO:0042157)2.45831443
158phospholipid efflux (GO:0033700)2.42788289
159response to thyroid hormone (GO:0097066)2.42745762
160positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.42709591
161aromatic amino acid family metabolic process (GO:0009072)2.41279988
162cellular glucuronidation (GO:0052695)2.40720795
163protein-lipid complex assembly (GO:0065005)2.39613873
164plasma lipoprotein particle assembly (GO:0034377)2.39224005
165positive regulation of hemostasis (GO:1900048)2.37548912
166positive regulation of blood coagulation (GO:0030194)2.37548912
167antigen processing and presentation of endogenous antigen (GO:0019883)2.37327809
168pentose-phosphate shunt (GO:0006098)2.36517475
1694-hydroxyproline metabolic process (GO:0019471)2.35992308
170reverse cholesterol transport (GO:0043691)2.35479352
171regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.34550929
172positive regulation of coagulation (GO:0050820)2.33675832
173NADPH regeneration (GO:0006740)2.33512054
174glucuronate metabolic process (GO:0019585)2.33487573
175uronic acid metabolic process (GO:0006063)2.33487573
176bile acid metabolic process (GO:0008206)2.32622809
177valine metabolic process (GO:0006573)2.31715969
178neutrophil activation involved in immune response (GO:0002283)2.31394617
179phospholipid homeostasis (GO:0055091)2.30961736
180cellular response to interferon-alpha (GO:0035457)2.29315581
181regulation of interleukin-8 biosynthetic process (GO:0045414)2.27880533
182carnitine metabolic process (GO:0009437)2.27808420
183folic acid-containing compound biosynthetic process (GO:0009396)2.26221082
184sterol homeostasis (GO:0055092)2.24346554
185macromolecular complex remodeling (GO:0034367)2.23661686

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.79351409
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.40674275
3IRF8_22096565_ChIP-ChIP_GC-B_Human3.21959066
4PPARA_22158963_ChIP-Seq_LIVER_Mouse3.20220080
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.00683198
6SCL_19346495_ChIP-Seq_HPC-7_Human2.98836097
7E2F7_22180533_ChIP-Seq_HELA_Human2.93660308
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.92325792
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.62190065
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.61965562
11EGR1_23403033_ChIP-Seq_LIVER_Mouse2.60796462
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.58587839
13CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.50347010
14* LXR_22158963_ChIP-Seq_LIVER_Mouse2.49702303
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.48220842
16SPI1_23127762_ChIP-Seq_K562_Human2.41707234
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.38494142
18LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.34037589
19CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.31968019
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26528696
21VDR_24787735_ChIP-Seq_THP-1_Human2.18836842
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14731764
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13428882
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.11121951
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.07207612
26* IRF8_27001747_Chip-Seq_BMDM_Mouse2.04022853
27SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.00584267
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.99510750
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.95566106
30LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.95254993
31SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94312656
32GATA2_21666600_ChIP-Seq_HMVEC_Human1.91286166
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.80904995
34* CLOCK_20551151_ChIP-Seq_293T_Human1.79572550
35RUNX_20019798_ChIP-Seq_JUKART_Human1.78240882
36Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76200041
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.75918444
38BRD4_27068464_Chip-Seq_AML-cells_Mouse1.73993857
39AR_21909140_ChIP-Seq_LNCAP_Human1.72122187
40RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.71841003
41GATA1_19941826_ChIP-Seq_K562_Human1.71276952
42FOXM1_23109430_ChIP-Seq_U2OS_Human1.69461365
43TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68989070
44FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.67975422
45STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.67010721
46GATA1_19941827_ChIP-Seq_MEL_Mouse1.66594695
47IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64428884
48MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60882396
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58298278
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56197199
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.55825213
52GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.54756228
53FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.53499466
54HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53075819
55MYC_18555785_ChIP-Seq_MESCs_Mouse1.52978781
56* TFEB_21752829_ChIP-Seq_HELA_Human1.52768946
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.48771945
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.48137834
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.43912165
60* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43897841
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.42935739
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.39751458
63* GATA2_19941826_ChIP-Seq_K562_Human1.39603220
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38542739
65SPI1_23547873_ChIP-Seq_NB4_Human1.37681589
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.36277645
67SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31189335
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.30803174
69STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.30412313
70VDR_21846776_ChIP-Seq_THP-1_Human1.26439342
71NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24441587
72NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.21930083
73GATA3_27048872_Chip-Seq_THYMUS_Human1.18868842
74PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18097585
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.17788625
76POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17234605
77CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16831949
78CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16078984
79MYC_22102868_ChIP-Seq_BL_Human1.15900307
80GATA1_22025678_ChIP-Seq_K562_Human1.13599786
81SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13088606
82UTX_26944678_Chip-Seq_JUKART_Human1.12992186
83KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.11781069
84PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11633141
85ELK3_25401928_ChIP-Seq_HUVEC_Human1.11134215
86ATF3_27146783_Chip-Seq_COLON_Human1.09483633
87GATA3_26560356_Chip-Seq_TH2_Human1.08733288
88E2F1_18555785_ChIP-Seq_MESCs_Mouse1.07887905
89TRIM28_21343339_ChIP-Seq_HEK293_Human1.06579934
90CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04697548
91MAF_26560356_Chip-Seq_TH1_Human1.04664670
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.04596957
93ESR1_21235772_ChIP-Seq_MCF-7_Human1.04298792
94TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03062888
95PU_27001747_Chip-Seq_BMDM_Mouse1.02647320
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.02202348
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01877505
98CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01670154
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.01378955
100* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.01275175
101MYC_18358816_ChIP-ChIP_MESCs_Mouse1.00527972
102TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.99955975
103PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99848209
104TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99457072
105CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98286403
106NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.98226659
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97953515
108MYC_19030024_ChIP-ChIP_MESCs_Mouse0.97297139
109ELF1_17652178_ChIP-ChIP_JURKAT_Human0.95602593
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.95441330
111GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95159762
112GATA4_25053715_ChIP-Seq_YYC3_Human0.94834789
113TCF7_22412390_ChIP-Seq_EML_Mouse0.94638879
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.94542604
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.94539688
116RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.94520697
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.94281570
118FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.93380766
119KLF4_18555785_ChIP-Seq_MESCs_Mouse0.92772716
120VDR_24763502_ChIP-Seq_THP-1_Human0.92651628
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.92577519
122DCP1A_22483619_ChIP-Seq_HELA_Human0.92376306
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.92037735
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.92037735
125MYB_26560356_Chip-Seq_TH1_Human0.91764368
126TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91698433
127KDM2B_26808549_Chip-Seq_SUP-B15_Human0.91540354
128GATA1_22383799_ChIP-Seq_G1ME_Mouse0.90739489
129HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90627651
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.90543013
131E2F4_17652178_ChIP-ChIP_JURKAT_Human0.90215620
132TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90165888
133ZNF263_19887448_ChIP-Seq_K562_Human0.90028054
134ESR1_15608294_ChIP-ChIP_MCF-7_Human0.89450158
135ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89442301
136MYB_26560356_Chip-Seq_TH2_Human0.89226842
137GATA6_25053715_ChIP-Seq_YYC3_Human0.88697197
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.88628854
139JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88435034
140STAT6_21828071_ChIP-Seq_BEAS2B_Human0.87657113
141STAT1_20625510_ChIP-Seq_HELA_Human0.86613445
142JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.86162804
143SOX2_20726797_ChIP-Seq_SW620_Human0.85901770
144GATA1_19941827_ChIP-Seq_MEL86_Mouse0.84917673
145IKZF1_21737484_ChIP-ChIP_HCT116_Human0.82876353
146SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.80003852
147SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.80003852
148NCOR1_26117541_ChIP-Seq_K562_Human0.79168179
149THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.76275604

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system3.84030321
2MP0005360_urolithiasis3.69463608
3MP0009840_abnormal_foam_cell3.44342353
4MP0005058_abnormal_lysosome_morphology3.03699654
5MP0003705_abnormal_hypodermis_morpholog2.87108147
6MP0005365_abnormal_bile_salt2.50576366
7MP0003191_abnormal_cellular_cholesterol2.50195245
8MP0005085_abnormal_gallbladder_physiolo2.32734708
9MP0003806_abnormal_nucleotide_metabolis2.30403747
10MP0005671_abnormal_response_to2.19574829
11MP0008875_abnormal_xenobiotic_pharmacok2.15106879
12MP0008438_abnormal_cutaneous_collagen2.13181708
13MP0008004_abnormal_stomach_pH2.05367923
14MP0003436_decreased_susceptibility_to1.99480295
15MP0003195_calcinosis1.92698346
16MP0003828_pulmonary_edema1.88993117
17MP0003172_abnormal_lysosome_physiology1.87680887
18MP0010352_gastrointestinal_tract_polyps1.80659946
19MP0003252_abnormal_bile_duct1.69259655
20MP0010329_abnormal_lipoprotein_level1.66604626
21MP0004019_abnormal_vitamin_homeostasis1.65094395
22MP0005332_abnormal_amino_acid1.61686651
23MP0001835_abnormal_antigen_presentation1.59707534
24MP0005083_abnormal_biliary_tract1.59428255
25MP0003186_abnormal_redox_activity1.58849539
26MP0006082_CNS_inflammation1.57042599
27MP0003300_gastrointestinal_ulcer1.56690540
28MP0003566_abnormal_cell_adhesion1.53094445
29MP0002138_abnormal_hepatobiliary_system1.48411516
30MP0003303_peritoneal_inflammation1.46925730
31MP0002419_abnormal_innate_immunity1.46487773
32MP0004510_myositis1.44519177
33MP0000609_abnormal_liver_physiology1.43271524
34MP0010307_abnormal_tumor_latency1.43001847
35MP0009643_abnormal_urine_homeostasis1.37353603
36MP0005023_abnormal_wound_healing1.34674143
37MP0005319_abnormal_enzyme/_coenzyme1.30558627
38MP0004947_skin_inflammation1.27968287
39MP0005164_abnormal_response_to1.27829362
40MP0005167_abnormal_blood-brain_barrier1.25151120
41MP0008469_abnormal_protein_level1.24983660
42MP0000604_amyloidosis1.24588991
43MP0000716_abnormal_immune_system1.23897317
44MP0005464_abnormal_platelet_physiology1.21748915
45MP0001533_abnormal_skeleton_physiology1.21668959
46MP0001666_abnormal_nutrient_absorption1.21650370
47MP0003183_abnormal_peptide_metabolism1.20577076
48MP0009785_altered_susceptibility_to1.19692165
49MP0003690_abnormal_glial_cell1.19608328
50MP0002398_abnormal_bone_marrow1.18559129
51MP0005025_abnormal_response_to1.17521822
52MP0002254_reproductive_system_inflammat1.16644726
53MP0005166_decreased_susceptibility_to1.16387261
54MP0004883_abnormal_blood_vessel1.15655485
55MP0010234_abnormal_vibrissa_follicle1.15496324
56MP0005165_increased_susceptibility_to1.15242704
57MP0000598_abnormal_liver_morphology1.14486623
58MP0006054_spinal_hemorrhage1.14459989
59MP0001851_eye_inflammation1.11534758
60MP0008260_abnormal_autophagy1.09961932
61MP0000685_abnormal_immune_system1.08795320
62MP0005000_abnormal_immune_tolerance1.08699849
63MP0003693_abnormal_embryo_hatching1.08368357
64MP0001958_emphysema1.07612237
65MP0005275_abnormal_skin_tensile1.07439035
66MP0002136_abnormal_kidney_physiology1.07271557
67MP0000249_abnormal_blood_vessel1.07096051
68MP0003724_increased_susceptibility_to1.07053248
69MP0005310_abnormal_salivary_gland1.06127742
70MP0009764_decreased_sensitivity_to1.05238522
71MP0002429_abnormal_blood_cell1.05044277
72MP0001845_abnormal_inflammatory_respons1.04832390
73MP0002452_abnormal_antigen_presenting1.04758352
74MP0000858_altered_metastatic_potential0.98759975
75MP0005076_abnormal_cell_differentiation0.98662327
76MP0003453_abnormal_keratinocyte_physiol0.97860946
77MP0001853_heart_inflammation0.97828696
78MP0005390_skeleton_phenotype0.96574779
79MP0002148_abnormal_hypersensitivity_rea0.96516713
80MP0002722_abnormal_immune_system0.96423771
81MP0001756_abnormal_urination0.96007054
82MP0000343_altered_response_to0.95492668
83MP0005408_hypopigmentation0.94647149
84MP0003448_altered_tumor_morphology0.94510655
85MP0002118_abnormal_lipid_homeostasis0.93558628
86MP0001542_abnormal_bone_strength0.92357720
87MP0000015_abnormal_ear_pigmentation0.91340487
88MP0003279_aneurysm0.91204327
89MP0005397_hematopoietic_system_phenotyp0.91109318
90MP0001545_abnormal_hematopoietic_system0.91109318
91MP0009763_increased_sensitivity_to0.90572313
92MP0009278_abnormal_bone_marrow0.90417167
93MP0003795_abnormal_bone_structure0.90247821
94MP0000569_abnormal_digit_pigmentation0.90040379
95MP0001800_abnormal_humoral_immune0.89801960
96MP0005451_abnormal_body_composition0.88415688
97MP0002166_altered_tumor_susceptibility0.87952258
98MP0002723_abnormal_immune_serum0.87446777
99MP0002060_abnormal_skin_morphology0.86150136
100MP0003763_abnormal_thymus_physiology0.85283964
101MP0002132_abnormal_respiratory_system0.84836298
102MP0005387_immune_system_phenotype0.84535309
103MP0001790_abnormal_immune_system0.84535309
104MP0002877_abnormal_melanocyte_morpholog0.84467683
105MP0002396_abnormal_hematopoietic_system0.84455816
106MP0003656_abnormal_erythrocyte_physiolo0.84356271
107MP0005584_abnormal_enzyme/coenzyme_acti0.82745010
108MP0001663_abnormal_digestive_system0.82096745
109MP0004808_abnormal_hematopoietic_stem0.81831560
110MP0000371_diluted_coat_color0.80690984
111MP0001915_intracranial_hemorrhage0.80247470
112MP0000490_abnormal_crypts_of0.80022081
113MP0000465_gastrointestinal_hemorrhage0.79501514
114MP0003866_abnormal_defecation0.79470943
115MP0002405_respiratory_system_inflammati0.78120928
116MP0009333_abnormal_splenocyte_physiolog0.77830687
117MP0009053_abnormal_anal_canal0.77716745
118MP0000689_abnormal_spleen_morphology0.77201040
119MP0002998_abnormal_bone_remodeling0.77157801
120MP0001819_abnormal_immune_cell0.76443373
121MP0002420_abnormal_adaptive_immunity0.75655803
122MP0002135_abnormal_kidney_morphology0.74818700
123MP0009384_cardiac_valve_regurgitation0.74790480
124MP0010155_abnormal_intestine_physiology0.74634406
125MP0005257_abnormal_intraocular_pressure0.74442815
126MP0004957_abnormal_blastocyst_morpholog0.74133694
127MP0001764_abnormal_homeostasis0.72272194
128MP0003091_abnormal_cell_migration0.72204250
129MP0001243_abnormal_dermal_layer0.71942299
130MP0003075_altered_response_to0.69179159
131MP0009765_abnormal_xenobiotic_induced0.66349319
132MP0000920_abnormal_myelination0.63507540
133MP0008874_decreased_physiological_sensi0.63061796
134MP0002006_tumorigenesis0.61836385
135MP0010386_abnormal_urinary_bladder0.57780692
136MP0002332_abnormal_exercise_endurance0.54233974
137MP0005647_abnormal_sex_gland0.53228177

Predicted human phenotypes

RankGene SetZ-score
1Petechiae (HP:0000967)4.43132149
2Prolonged bleeding time (HP:0003010)4.38816942
3Purpura (HP:0000979)4.38024884
4Vacuolated lymphocytes (HP:0001922)4.15822186
5Xanthomatosis (HP:0000991)3.98258129
6Systemic lupus erythematosus (HP:0002725)3.88164921
7Epistaxis (HP:0000421)3.76400412
8Deep venous thrombosis (HP:0002625)3.52800718
9Myocardial infarction (HP:0001658)3.46655492
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42459299
11Increased cerebral lipofuscin (HP:0011813)3.41944236
12Spontaneous hematomas (HP:0007420)3.34509017
13Loss of speech (HP:0002371)3.34214521
14Complement deficiency (HP:0004431)3.31175579
15Dysostosis multiplex (HP:0000943)3.28980347
16Abnormal platelet volume (HP:0011876)3.28406170
17Recurrent gram-negative bacterial infections (HP:0005420)3.25560289
18Increased mean platelet volume (HP:0011877)3.22204300
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.19151885
20Abnormality of aromatic amino acid family metabolism (HP:0004338)3.14124184
21Intrahepatic cholestasis (HP:0001406)3.13252422
22Menorrhagia (HP:0000132)3.04746877
23Chronic obstructive pulmonary disease (HP:0006510)3.04249215
24Obstructive lung disease (HP:0006536)3.04249215
25Glomerulonephritis (HP:0000099)3.02649303
26Mucopolysacchariduria (HP:0008155)3.01025170
27Urinary glycosaminoglycan excretion (HP:0003541)3.01025170
28Abnormality of macrophages (HP:0004311)2.95717020
29Abnormality of complement system (HP:0005339)2.93073419
30Increased neuronal autofluorescent lipopigment (HP:0002074)2.92443832
31Recurrent abscess formation (HP:0002722)2.89345581
32Hyperlipoproteinemia (HP:0010980)2.89255671
33Hypobetalipoproteinemia (HP:0003563)2.89001084
34Mediastinal lymphadenopathy (HP:0100721)2.86504137
35Hepatosplenomegaly (HP:0001433)2.84833259
36Stomatitis (HP:0010280)2.83122030
37Amyloidosis (HP:0011034)2.80182357
38Recurrent bacterial skin infections (HP:0005406)2.79882102
39Eczematoid dermatitis (HP:0000976)2.78699786
40Orchitis (HP:0100796)2.78690532
41Recurrent skin infections (HP:0001581)2.75526677
42Abnormality of mucopolysaccharide metabolism (HP:0011020)2.75192107
43Abnormality of polysaccharide metabolism (HP:0011012)2.75192107
44Abnormality of glycosaminoglycan metabolism (HP:0004371)2.75192107
45Joint hemorrhage (HP:0005261)2.73726858
46Elevated erythrocyte sedimentation rate (HP:0003565)2.66617159
47Impaired platelet aggregation (HP:0003540)2.64849755
48Abnormal platelet function (HP:0011869)2.64849755
49Abnormality of the common coagulation pathway (HP:0010990)2.62990639
50Osteolytic defects of the hand bones (HP:0009699)2.61456479
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.61456479
52Esophageal varix (HP:0002040)2.57977535
53Abnormality of glycolipid metabolism (HP:0010969)2.57181070
54Abnormality of liposaccharide metabolism (HP:0010968)2.57181070
55Abnormality of glycosphingolipid metabolism (HP:0004343)2.57181070
56Hypolipoproteinemia (HP:0010981)2.56425013
57Hyperglycinuria (HP:0003108)2.55388360
58Recurrent fungal infections (HP:0002841)2.54631377
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.53725717
60Axonal loss (HP:0003447)2.51570255
61Hypoalphalipoproteinemia (HP:0003233)2.50043971
62Retrobulbar optic neuritis (HP:0100654)2.47816314
63Optic neuritis (HP:0100653)2.47816314
64Hypoglycemic coma (HP:0001325)2.46895929
65Hyperammonemia (HP:0001987)2.46817767
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.44430461
67Prolonged partial thromboplastin time (HP:0003645)2.44010838
68Peritonitis (HP:0002586)2.43703662
69Gingivitis (HP:0000230)2.43578142
70Abnormality of sulfur amino acid metabolism (HP:0004339)2.40887018
71Nausea (HP:0002018)2.39362607
72Abnormality of proline metabolism (HP:0010907)2.39212133
73Hydroxyprolinuria (HP:0003080)2.39212133
74Abnormality of serine family amino acid metabolism (HP:0010894)2.38461360
75Abnormality of glycine metabolism (HP:0010895)2.38461360
76Hematochezia (HP:0002573)2.38032865
77Spastic diplegia (HP:0001264)2.35443537
78Hyperglycinemia (HP:0002154)2.33548072
79Hypercholesterolemia (HP:0003124)2.32924046
80Cervical subluxation (HP:0003308)2.32499328
81Premature rupture of membranes (HP:0001788)2.32011202
82Arterial thrombosis (HP:0004420)2.31406783
83Pustule (HP:0200039)2.28830154
84Abnormality of pyrimidine metabolism (HP:0004353)2.28470329
85Nephritis (HP:0000123)2.26558102
86Vertebral compression fractures (HP:0002953)2.25977094
87Progressive neurologic deterioration (HP:0002344)2.23643529
88Pulmonary infiltrates (HP:0002113)2.21684507
89Abnormality of nucleobase metabolism (HP:0010932)2.21502360
90Urticaria (HP:0001025)2.20143697
91Keratoconjunctivitis sicca (HP:0001097)2.19428531
92Basal ganglia calcification (HP:0002135)2.19010631
93Chest pain (HP:0100749)2.19005914
94Spondylolisthesis (HP:0003302)2.18317416
95Abnormality of purine metabolism (HP:0004352)2.18018375
96Disinhibition (HP:0000734)2.17586708
97Recurrent cutaneous fungal infections (HP:0011370)2.16573816
98Chronic mucocutaneous candidiasis (HP:0002728)2.16573816
99Meningitis (HP:0001287)2.14116293
100Abnormality of the intrinsic pathway (HP:0010989)2.13983556
101Recurrent viral infections (HP:0004429)2.13376090
102Conjunctival telangiectasia (HP:0000524)2.12330720
103Fat malabsorption (HP:0002630)2.12198843
104Thrombocytosis (HP:0001894)2.11682454
105Protrusio acetabuli (HP:0003179)2.08043593
106Mutism (HP:0002300)2.07260883
107Hemoptysis (HP:0002105)2.06589536
108Abnormality of the prostate (HP:0008775)2.05432474
109Vasculitis (HP:0002633)2.02309437
110Abnormality of iron homeostasis (HP:0011031)2.02152714
111Hepatocellular carcinoma (HP:0001402)2.01251257
112Abnormality of fatty-acid metabolism (HP:0004359)2.01210863
113Autoimmune thrombocytopenia (HP:0001973)2.00736630
114Cardiovascular calcification (HP:0011915)2.00646420
115Cellulitis (HP:0100658)2.00567131
116Interstitial pulmonary disease (HP:0006530)1.99919251
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.99671155
118Abnormality of transition element cation homeostasis (HP:0011030)1.99407376
119Pathologic fracture (HP:0002756)1.99224565
120Tetraparesis (HP:0002273)1.98773683
121Vascular calcification (HP:0004934)1.98334119
122Keratoconjunctivitis (HP:0001096)1.97855084
123Mucosal telangiectasiae (HP:0100579)1.94240943
124Polycythemia (HP:0001901)1.93647622
125Increased serum ferritin (HP:0003281)1.93167699
126Proximal tubulopathy (HP:0000114)1.92385239
127T lymphocytopenia (HP:0005403)1.91700468
128Mitral stenosis (HP:0001718)1.91079402
129Bruising susceptibility (HP:0000978)1.90709074
130Gout (HP:0001997)1.90283652
131Ketosis (HP:0001946)1.89925761
132Neurofibrillary tangles (HP:0002185)1.89800856
133Pulmonary embolism (HP:0002204)1.88272889
134Gingival bleeding (HP:0000225)1.87524468
135Epidermoid cyst (HP:0200040)1.86444471
136Skin nodule (HP:0200036)1.86418727
137Abnormal cartilage morphology (HP:0002763)1.85035389
138Upper motor neuron abnormality (HP:0002127)1.84688785
139Generalized aminoaciduria (HP:0002909)1.82956322
140Asymmetric septal hypertrophy (HP:0001670)1.81783111
141Leukocytosis (HP:0001974)1.81673361
142Thrombophlebitis (HP:0004418)1.81130339
143Vertigo (HP:0002321)1.81064291
144Osteomyelitis (HP:0002754)1.80837918
145Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.80157787
146Episodic fever (HP:0001954)1.79288174
147Protuberant abdomen (HP:0001538)1.78736718
148Abnormality of T cell number (HP:0011839)1.78591652
149Amaurosis fugax (HP:0100576)1.78588194
150Polyneuropathy (HP:0001271)1.78231125
151J-shaped sella turcica (HP:0002680)1.77874735
152Encephalitis (HP:0002383)1.77508261
153Global brain atrophy (HP:0002283)1.76742002
154Thoracic kyphosis (HP:0002942)1.75746963
155Myositis (HP:0100614)1.75680415
156Steatorrhea (HP:0002570)1.75520162
157Autoimmune hemolytic anemia (HP:0001890)1.75217555
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.71971107
159Abnormality of methionine metabolism (HP:0010901)1.71827778
160Abnormality of the distal phalanges of the toes (HP:0010182)1.71643892
161Joint swelling (HP:0001386)1.71506727
162Hypergammaglobulinemia (HP:0010702)1.70796570

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.02002857
2ERN13.25784794
3SCYL22.73395862
4TRIB32.41061710
5TYK22.37845379
6BMPR22.37700914
7BCKDK2.25442748
8TBK12.24187865
9PKN22.14680743
10NME22.11638451
11TGFBR22.07413495
12BLK2.04103003
13NEK91.96254533
14FES1.92607466
15SYK1.91341628
16STK101.89860931
17TEC1.79718532
18GRK71.78878602
19MAP3K31.76075844
20LRRK21.73016143
21EPHA21.72392165
22FGFR41.64532306
23KIT1.60726118
24PIM21.56502489
25MAP2K31.54566060
26FGR1.54437843
27PAK41.54063300
28MAP3K141.46029626
29RPS6KA41.45063815
30IRAK31.43429340
31MST1R1.43235722
32PRPF4B1.38245778
33MYLK1.36974735
34PBK1.36708069
35CAMKK21.35444346
36WEE11.33697788
37FLT31.33590549
38CSF1R1.32301985
39TAOK21.29441074
40SIK11.29003067
41IKBKB1.27799500
42MAP4K11.27753660
43ZAP701.26012444
44TTN1.25086518
45EIF2AK11.24199226
46PTK61.22749719
47JAK31.20505986
48MAP3K131.19658849
49MAP3K81.16129429
50KDR1.14754039
51TXK1.12027080
52PIM11.09616362
53NEK21.09519973
54CDK61.09320751
55IRAK41.09190612
56RIPK11.08041329
57JAK11.07443174
58ABL21.06906183
59STK31.06526226
60EIF2AK31.05751394
61MAP3K111.01610642
62LATS10.99084654
63FRK0.98902735
64TAOK30.95077209
65CSK0.94848206
66CAMK1D0.94608842
67LCK0.91979608
68MST40.90998472
69IKBKE0.90114185
70BUB10.90110633
71TESK20.89285577
72MAP3K60.88596580
73MAP3K10.87630594
74ITK0.86775808
75TAOK10.84882969
76CHUK0.83647920
77BRSK20.83337562
78NEK10.83221912
79STK40.82168439
80PDPK10.82096122
81TNK20.80804783
82DDR20.77856355
83MOS0.77587340
84JAK20.76917873
85PTK2B0.76025130
86CDK40.75870928
87MET0.74929050
88TGFBR10.74702048
89MATK0.74392209
90IRAK10.73435424
91PDGFRA0.72984190
92PDK10.72596120
93EEF2K0.72348471
94BMX0.71344270
95CDC42BPA0.70791658
96IRAK20.70301518
97ACVR1B0.69849508
98EPHB10.69529920
99MAP3K100.69107746
100TTK0.69006248
101PDK20.68090863
102GRK60.68036447
103TRPM70.67903486
104ADRBK20.67480756
105BTK0.65858692
106MAP2K20.63818292
107PAK20.62761422
108MAP3K50.61072036
109DYRK1B0.60621028
110MAPK120.60485195
111MAPKAPK30.58525863
112RPS6KB20.57495450
113PTK20.56088638
114LYN0.55203522
115MAPK110.54538988
116MARK30.54261827
117MAPK70.54166839
118HCK0.54047068
119ERBB40.52709544
120EGFR0.52676913
121NUAK10.52235998
122FGFR30.51832796
123ARAF0.50776037
124TESK10.49667583
125PIK3CG0.49238394
126MTOR0.48392677
127AURKB0.48038157
128CDK120.48002137
129YES10.47612277
130FER0.45948504
131EPHA30.45705538
132ABL10.45695638
133FYN0.45216261
134DYRK30.44744510
135MAP3K120.44254052
136MAP3K20.43943291
137MAPKAPK20.43091954
138PRKD10.42125492
139MAPK40.40929913
140HIPK20.40853973
141SIK30.39492772
142RPS6KL10.39406577
143RPS6KC10.39406577
144PRKCD0.38917000
145PDGFRB0.36414471
146DAPK30.36382861
147RPS6KA20.36233526
148GRK50.35874671
149IGF1R0.34960578
150ILK0.33813207

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053102.96542211
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79984055
3Staphylococcus aureus infection_Homo sapiens_hsa051502.70802541
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.70670340
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.58527312
6Allograft rejection_Homo sapiens_hsa053302.50084896
7Graft-versus-host disease_Homo sapiens_hsa053322.34949208
8Rheumatoid arthritis_Homo sapiens_hsa053232.32998154
9Nitrogen metabolism_Homo sapiens_hsa009102.28883164
10Complement and coagulation cascades_Homo sapiens_hsa046102.24640844
11Autoimmune thyroid disease_Homo sapiens_hsa053202.22784301
12Intestinal immune network for IgA production_Homo sapiens_hsa046722.16769444
13Glycosaminoglycan degradation_Homo sapiens_hsa005312.00151211
14Caffeine metabolism_Homo sapiens_hsa002321.96995310
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.92177469
16Hematopoietic cell lineage_Homo sapiens_hsa046401.91802925
17Lysosome_Homo sapiens_hsa041421.89344386
18Arginine biosynthesis_Homo sapiens_hsa002201.86385385
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.85498720
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82278357
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.81961104
22Type I diabetes mellitus_Homo sapiens_hsa049401.80404017
23Other glycan degradation_Homo sapiens_hsa005111.76190347
24Platelet activation_Homo sapiens_hsa046111.74721132
25Selenocompound metabolism_Homo sapiens_hsa004501.68283642
26Fatty acid degradation_Homo sapiens_hsa000711.67093677
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.65824097
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.65591567
29Tryptophan metabolism_Homo sapiens_hsa003801.58835713
30Folate biosynthesis_Homo sapiens_hsa007901.52500041
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49236906
32Peroxisome_Homo sapiens_hsa041461.48905494
33B cell receptor signaling pathway_Homo sapiens_hsa046621.44067152
34Viral myocarditis_Homo sapiens_hsa054161.42857937
35One carbon pool by folate_Homo sapiens_hsa006701.39250326
36Salmonella infection_Homo sapiens_hsa051321.30791462
37PPAR signaling pathway_Homo sapiens_hsa033201.27517815
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25241257
39Leishmaniasis_Homo sapiens_hsa051401.24735598
40Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24189872
41Histidine metabolism_Homo sapiens_hsa003401.23774411
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.23536299
43Chemical carcinogenesis_Homo sapiens_hsa052041.22041367
44Pentose phosphate pathway_Homo sapiens_hsa000301.21246774
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.21102513
46Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.19752445
47SNARE interactions in vesicular transport_Homo sapiens_hsa041301.18757066
482-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.17422246
49Legionellosis_Homo sapiens_hsa051341.17249767
50Chemokine signaling pathway_Homo sapiens_hsa040621.15066395
51Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.14023980
52beta-Alanine metabolism_Homo sapiens_hsa004101.10997695
53Vitamin digestion and absorption_Homo sapiens_hsa049771.10243816
54Collecting duct acid secretion_Homo sapiens_hsa049661.08443782
55Starch and sucrose metabolism_Homo sapiens_hsa005001.07327037
56Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.03892363
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.03517950
58Antigen processing and presentation_Homo sapiens_hsa046121.02776273
59Carbon metabolism_Homo sapiens_hsa012001.01969315
60Fatty acid metabolism_Homo sapiens_hsa012120.99220912
61Biosynthesis of amino acids_Homo sapiens_hsa012300.98117251
62Retinol metabolism_Homo sapiens_hsa008300.97765732
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96492838
64Glutathione metabolism_Homo sapiens_hsa004800.94844146
65Steroid hormone biosynthesis_Homo sapiens_hsa001400.94616269
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93775323
67Sulfur relay system_Homo sapiens_hsa041220.93314195
68Amoebiasis_Homo sapiens_hsa051460.92880292
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91367655
70Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.91226806
71Propanoate metabolism_Homo sapiens_hsa006400.90345941
72Toll-like receptor signaling pathway_Homo sapiens_hsa046200.90004989
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89508147
74Proteasome_Homo sapiens_hsa030500.88715455
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87423177
76Sphingolipid metabolism_Homo sapiens_hsa006000.87006762
77Pertussis_Homo sapiens_hsa051330.86734735
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.83883135
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.83433468
80Butanoate metabolism_Homo sapiens_hsa006500.83378877
81Malaria_Homo sapiens_hsa051440.80494411
82Steroid biosynthesis_Homo sapiens_hsa001000.79882571
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.77565869
84Phenylalanine metabolism_Homo sapiens_hsa003600.76794389
85Acute myeloid leukemia_Homo sapiens_hsa052210.75502617
86Tuberculosis_Homo sapiens_hsa051520.74281688
87Vitamin B6 metabolism_Homo sapiens_hsa007500.73678708
88Apoptosis_Homo sapiens_hsa042100.72778480
89Phagosome_Homo sapiens_hsa041450.72760713
90Bile secretion_Homo sapiens_hsa049760.72073036
91Osteoclast differentiation_Homo sapiens_hsa043800.71906970
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70310975
93T cell receptor signaling pathway_Homo sapiens_hsa046600.68950010
94Arginine and proline metabolism_Homo sapiens_hsa003300.68792604
95Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68780904
96ABC transporters_Homo sapiens_hsa020100.68697899
97Fat digestion and absorption_Homo sapiens_hsa049750.68200624
98Hepatitis B_Homo sapiens_hsa051610.66917088
99Arachidonic acid metabolism_Homo sapiens_hsa005900.66669627
100Galactose metabolism_Homo sapiens_hsa000520.66636696
101African trypanosomiasis_Homo sapiens_hsa051430.65275218
102Renin-angiotensin system_Homo sapiens_hsa046140.64656604
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63944736
104p53 signaling pathway_Homo sapiens_hsa041150.62264667
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60234552
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59688700
107DNA replication_Homo sapiens_hsa030300.59411933
108Shigellosis_Homo sapiens_hsa051310.59403191
109Primary immunodeficiency_Homo sapiens_hsa053400.58638039
110Systemic lupus erythematosus_Homo sapiens_hsa053220.58497945
111Pancreatic cancer_Homo sapiens_hsa052120.57910358
112Endocytosis_Homo sapiens_hsa041440.57683870
113Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.57646803
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57240074
115Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55747989
116Toxoplasmosis_Homo sapiens_hsa051450.55360739
117Measles_Homo sapiens_hsa051620.55232367
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.55203243
119Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54650417
120Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54537965
121RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54284253
122Small cell lung cancer_Homo sapiens_hsa052220.53152633
123Sulfur metabolism_Homo sapiens_hsa009200.51979815
124Vibrio cholerae infection_Homo sapiens_hsa051100.51704758
125Lysine degradation_Homo sapiens_hsa003100.51406359
126Bladder cancer_Homo sapiens_hsa052190.50651153
127Fructose and mannose metabolism_Homo sapiens_hsa000510.50018751
128Herpes simplex infection_Homo sapiens_hsa051680.48894871
129Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48777585
130Tyrosine metabolism_Homo sapiens_hsa003500.48534566
131Influenza A_Homo sapiens_hsa051640.48515367
132NOD-like receptor signaling pathway_Homo sapiens_hsa046210.48464030
133Adipocytokine signaling pathway_Homo sapiens_hsa049200.47021522
134Pyruvate metabolism_Homo sapiens_hsa006200.46198892
135Glycerolipid metabolism_Homo sapiens_hsa005610.44411413
136Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.44104043
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43937214
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42940458
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.42534416
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41578631
141TNF signaling pathway_Homo sapiens_hsa046680.41135618
142Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39055188
143Hepatitis C_Homo sapiens_hsa051600.38585757
144Viral carcinogenesis_Homo sapiens_hsa052030.37471470
145Chronic myeloid leukemia_Homo sapiens_hsa052200.33381431
146VEGF signaling pathway_Homo sapiens_hsa043700.33342630
147Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33112882
148Non-small cell lung cancer_Homo sapiens_hsa052230.33110045
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.32584283
150Neurotrophin signaling pathway_Homo sapiens_hsa047220.32448849
151Prolactin signaling pathway_Homo sapiens_hsa049170.31792007
152Prion diseases_Homo sapiens_hsa050200.28563007
153Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.28461215
154HIF-1 signaling pathway_Homo sapiens_hsa040660.28386247
155Renal cell carcinoma_Homo sapiens_hsa052110.25279946
156Glycerophospholipid metabolism_Homo sapiens_hsa005640.23937164
157Mineral absorption_Homo sapiens_hsa049780.21800108

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