MFSD10

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.09511459
2ribosomal small subunit assembly (GO:0000028)5.89005674
3DNA strand elongation involved in DNA replication (GO:0006271)5.07483198
4telomere maintenance via semi-conservative replication (GO:0032201)4.97395808
5viral transcription (GO:0019083)4.96645353
6DNA strand elongation (GO:0022616)4.88916909
7translational termination (GO:0006415)4.80128165
8negative regulation of erythrocyte differentiation (GO:0045647)4.66806860
9DNA unwinding involved in DNA replication (GO:0006268)4.66528899
10DNA replication initiation (GO:0006270)4.53161441
11maturation of SSU-rRNA (GO:0030490)4.37219476
12translational elongation (GO:0006414)4.36936071
13SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.35535906
14ribosomal small subunit biogenesis (GO:0042274)4.34302948
15telomere maintenance via recombination (GO:0000722)4.28426237
16mannose metabolic process (GO:0006013)4.27804684
17cotranslational protein targeting to membrane (GO:0006613)4.22720543
18protein targeting to ER (GO:0045047)4.21778527
19protein retention in ER lumen (GO:0006621)4.05117286
20response to peptidoglycan (GO:0032494)4.03103907
21establishment of protein localization to endoplasmic reticulum (GO:0072599)4.00064054
22protein localization to endoplasmic reticulum (GO:0070972)3.97229533
23translational initiation (GO:0006413)3.92335419
24nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.92257270
25mitotic recombination (GO:0006312)3.91526802
26formation of translation preinitiation complex (GO:0001731)3.91085751
27telomere maintenance via telomere lengthening (GO:0010833)3.86799063
28maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.84392202
29viral life cycle (GO:0019058)3.76796618
30COPI coating of Golgi vesicle (GO:0048205)3.76719488
31Golgi transport vesicle coating (GO:0048200)3.76719488
32response to muramyl dipeptide (GO:0032495)3.72133094
33barbed-end actin filament capping (GO:0051016)3.70355842
34cellular protein complex disassembly (GO:0043624)3.68443300
35pinocytosis (GO:0006907)3.67697809
36pentose-phosphate shunt (GO:0006098)3.62149891
37deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.57461791
38nucleobase biosynthetic process (GO:0046112)3.57376884
39DNA replication checkpoint (GO:0000076)3.57192305
40ribosomal large subunit biogenesis (GO:0042273)3.47777833
41nucleotide-excision repair, DNA gap filling (GO:0006297)3.47536864
42IMP biosynthetic process (GO:0006188)3.46916707
43ribonucleoprotein complex biogenesis (GO:0022613)3.45331313
44pseudouridine synthesis (GO:0001522)3.38929048
45protein complex disassembly (GO:0043241)3.37540352
46negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.36457464
47NIK/NF-kappaB signaling (GO:0038061)3.35582117
48protein localization to kinetochore (GO:0034501)3.29033041
49activation of Rac GTPase activity (GO:0032863)3.28843841
50glucose catabolic process (GO:0006007)3.28415090
51positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.26354329
52negative regulation of cell size (GO:0045792)3.25459453
53folic acid-containing compound biosynthetic process (GO:0009396)3.20940018
54IMP metabolic process (GO:0046040)3.18081535
55ribosome biogenesis (GO:0042254)3.17639065
56macromolecular complex disassembly (GO:0032984)3.17016310
57purine nucleobase biosynthetic process (GO:0009113)3.15320366
58nuclear-transcribed mRNA catabolic process (GO:0000956)3.14866118
59regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12932103
60translation (GO:0006412)3.08025752
61rRNA processing (GO:0006364)3.07120240
62CENP-A containing nucleosome assembly (GO:0034080)3.03743123
63antigen processing and presentation of endogenous antigen (GO:0019883)3.02514516
64NADPH regeneration (GO:0006740)3.02511235
65mRNA catabolic process (GO:0006402)3.00816000
66modulation by symbiont of host cellular process (GO:0044068)2.98740769
67protein localization to endosome (GO:0036010)2.98727430
68modulation by virus of host process (GO:0019054)2.97377536
69RNA catabolic process (GO:0006401)2.96305453
70rRNA metabolic process (GO:0016072)2.95007409
71regulation of chromatin binding (GO:0035561)2.95003204
72chromatin remodeling at centromere (GO:0031055)2.94020799
73positive regulation of gamma-delta T cell activation (GO:0046645)2.92921675
74positive regulation of B cell differentiation (GO:0045579)2.89981355
75mitotic nuclear envelope disassembly (GO:0007077)2.89264549
76negative regulation of RNA splicing (GO:0033119)2.89104141
77negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.88120096
78telomere maintenance (GO:0000723)2.86042671
79telomere organization (GO:0032200)2.86013100
80positive regulation of Cdc42 GTPase activity (GO:0043089)2.85025787
81regulation of mammary gland epithelial cell proliferation (GO:0033599)2.84140469
82antigen processing and presentation via MHC class Ib (GO:0002475)2.83886839
83negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82350126
84protein localization to chromosome, centromeric region (GO:0071459)2.81716184
85positive regulation of histone deacetylation (GO:0031065)2.79337433
86spliceosomal snRNP assembly (GO:0000387)2.78415374
87apoptotic process involved in morphogenesis (GO:0060561)2.77431057
88regulation of protein heterodimerization activity (GO:0043497)2.76946760
89DNA duplex unwinding (GO:0032508)2.76063552
90protein targeting to membrane (GO:0006612)2.75798090
91DNA replication-independent nucleosome organization (GO:0034724)2.75696581
92DNA replication-independent nucleosome assembly (GO:0006336)2.75696581
93DNA replication-dependent nucleosome assembly (GO:0006335)2.75210691
94DNA replication-dependent nucleosome organization (GO:0034723)2.75210691
95UV protection (GO:0009650)2.74670790
96GDP-mannose metabolic process (GO:0019673)2.74020457
97DNA geometric change (GO:0032392)2.72696231
98regulation of nuclear cell cycle DNA replication (GO:0033262)2.71983783
99antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.71562139
100antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.71562139
101antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.71523745
102establishment of integrated proviral latency (GO:0075713)2.71380655
103retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70717613
104regulation of leukocyte degranulation (GO:0043300)2.68073521
105protein maturation by protein folding (GO:0022417)2.68018769
106intracellular estrogen receptor signaling pathway (GO:0030520)2.67758485
107cellular response to virus (GO:0098586)2.67741731
108positive regulation of cell adhesion mediated by integrin (GO:0033630)2.67359246
109negative regulation of interleukin-8 production (GO:0032717)2.66274974
110activation of MAPKKK activity (GO:0000185)2.66046899
111thymic T cell selection (GO:0045061)2.65904397
112detection of bacterium (GO:0016045)2.65875548
113exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.65659102
114transcription-coupled nucleotide-excision repair (GO:0006283)2.65493545
115somatic diversification of immune receptors via somatic mutation (GO:0002566)2.63545967
116somatic hypermutation of immunoglobulin genes (GO:0016446)2.63545967
117positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63533141
118immunoglobulin mediated immune response (GO:0016064)2.62040139
119nuclear envelope disassembly (GO:0051081)2.61325092
120membrane disassembly (GO:0030397)2.61325092
121regulation of double-strand break repair via homologous recombination (GO:0010569)2.60599509
122stress fiber assembly (GO:0043149)2.60283474
123response to interferon-beta (GO:0035456)2.59951665
124B cell mediated immunity (GO:0019724)2.59947263
125translesion synthesis (GO:0019985)2.58608838
126base-excision repair (GO:0006284)2.57055833
127somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.55482417
128somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.55482417
129isotype switching (GO:0045190)2.55482417
130positive thymic T cell selection (GO:0045059)2.55462750
131cell cycle G1/S phase transition (GO:0044843)2.55159495
132G1/S transition of mitotic cell cycle (GO:0000082)2.55159495
133cellular component biogenesis (GO:0044085)2.54325938
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.54084655
135pteridine-containing compound biosynthetic process (GO:0042559)2.53724625
136negative regulation of phagocytosis (GO:0050765)2.53538849
137ribosome assembly (GO:0042255)2.53403995
138regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53262912
139leukocyte aggregation (GO:0070486)2.53230853
140regulation of mast cell degranulation (GO:0043304)2.52511571
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.52368530
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.52368530
143modulation by symbiont of host immune response (GO:0052553)2.52368530
144positive regulation by symbiont of host defense response (GO:0052509)2.52368530
145modulation by symbiont of host defense response (GO:0052031)2.52368530
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.52368530
147hemidesmosome assembly (GO:0031581)2.52255144
148nucleobase-containing small molecule interconversion (GO:0015949)2.51028479
149regulation of myeloid leukocyte mediated immunity (GO:0002886)2.50993780
1503-UTR-mediated mRNA stabilization (GO:0070935)2.50142605
151nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.50051175
152negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.49463242
153negative regulation of cell killing (GO:0031342)2.49463242
154detection of other organism (GO:0098543)2.49419765
155pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.48562592
156Arp2/3 complex-mediated actin nucleation (GO:0034314)2.47331743
157termination of RNA polymerase II transcription (GO:0006369)2.47324638
158antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.47323412
159tRNA methylation (GO:0030488)2.47062674
160viral mRNA export from host cell nucleus (GO:0046784)2.46798124
161semaphorin-plexin signaling pathway (GO:0071526)2.46247922
162embryonic process involved in female pregnancy (GO:0060136)2.46057826
163response to laminar fluid shear stress (GO:0034616)2.44298103
164regulation of necrotic cell death (GO:0010939)2.43792695
165mature B cell differentiation involved in immune response (GO:0002313)2.42510983
166proline biosynthetic process (GO:0006561)2.41903959
167respiratory burst (GO:0045730)2.41229351
168snRNA metabolic process (GO:0016073)2.40400593
169regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.40176501
170neutrophil activation involved in immune response (GO:0002283)2.39194773
171cellular extravasation (GO:0045123)2.39020074
172endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.38931409
173amyloid precursor protein catabolic process (GO:0042987)2.38888571
174lipopolysaccharide-mediated signaling pathway (GO:0031663)2.38855787
175regulation of extracellular matrix disassembly (GO:0010715)2.38491395
176regulation of B cell differentiation (GO:0045577)2.38100508
177activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.35790220
178planar cell polarity pathway involved in neural tube closure (GO:0090179)2.35625124
179response to progesterone (GO:0032570)2.34047751
180protein kinase C signaling (GO:0070528)2.33877864
181regulation of monocyte differentiation (GO:0045655)2.31300523
182hypotonic response (GO:0006971)2.31215049
183maternal placenta development (GO:0001893)2.31103760
184positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.30019088
185regulation of chemokine biosynthetic process (GO:0045073)2.29745324
186regulation of defense response to virus by virus (GO:0050690)2.29577840
187positive regulation of nuclease activity (GO:0032075)2.27062820
188glial cell migration (GO:0008347)2.25840683
189germinal center formation (GO:0002467)2.25727838
190cell-substrate junction assembly (GO:0007044)2.25451428
191negative regulation of granulocyte differentiation (GO:0030853)2.24443448
192regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.23076053
193negative regulation of viral release from host cell (GO:1902187)2.22794953
194positive regulation of protein deacetylation (GO:0090312)2.22501245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53552806
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.96615043
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.89359679
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.96045604
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.75548423
6* LXR_22292898_ChIP-Seq_THP-1_Human2.75497100
7MYC_18358816_ChIP-ChIP_MESCs_Mouse2.66630331
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.59202835
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59052446
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.54351502
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.53711432
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.50773235
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.48909949
14MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45741561
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.44029942
16GABP_17652178_ChIP-ChIP_JURKAT_Human2.43665517
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.42006730
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.41371886
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.36096514
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.35745002
21* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.35297384
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.32065604
23KDM2B_26808549_Chip-Seq_SUP-B15_Human2.28748414
24MYC_22102868_ChIP-Seq_BL_Human2.27846433
25HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.24269909
26XRN2_22483619_ChIP-Seq_HELA_Human2.15339792
27TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.14454136
28THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.08955771
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.04327855
30RACK7_27058665_Chip-Seq_MCF-7_Human2.01973355
31KDM2B_26808549_Chip-Seq_DND41_Human2.01120009
32CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98244674
33VDR_23849224_ChIP-Seq_CD4+_Human1.98239432
34* VDR_21846776_ChIP-Seq_THP-1_Human1.97049087
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.94901532
36NELFA_20434984_ChIP-Seq_ESCs_Mouse1.94057328
37FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.90267751
38NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83843834
39E2F1_18555785_ChIP-Seq_MESCs_Mouse1.83392575
40FOXP3_21729870_ChIP-Seq_TREG_Human1.81073032
41PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77121345
42CIITA_25753668_ChIP-Seq_RAJI_Human1.74005319
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73132029
44DCP1A_22483619_ChIP-Seq_HELA_Human1.72967932
45SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.72553148
46MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.69212457
47* GABP_19822575_ChIP-Seq_HepG2_Human1.69171545
48E2F1_21310950_ChIP-Seq_MCF-7_Human1.66301424
49BP1_19119308_ChIP-ChIP_Hs578T_Human1.66242355
50P68_20966046_ChIP-Seq_HELA_Human1.64327059
51SCL_19346495_ChIP-Seq_HPC-7_Human1.64136022
52ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63903709
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63385360
54TTF2_22483619_ChIP-Seq_HELA_Human1.61035913
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.59969538
56ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57277568
57HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57133468
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.56586190
59ZNF263_19887448_ChIP-Seq_K562_Human1.55638700
60* TET1_21451524_ChIP-Seq_MESCs_Mouse1.55459574
61SPI1_23547873_ChIP-Seq_NB4_Human1.53717277
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.52226189
63CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52137175
64E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52091971
65MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.50437686
66IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.49115579
67HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47034006
68* SA1_27219007_Chip-Seq_ERYTHROID_Human1.46986630
69YY1_21170310_ChIP-Seq_MESCs_Mouse1.46677251
70ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46588958
71KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.46554526
72NANOG_18555785_ChIP-Seq_MESCs_Mouse1.45797349
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.45701537
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44818885
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.44553778
76MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44425096
77IRF8_22096565_ChIP-ChIP_GC-B_Human1.43741450
78AR_21909140_ChIP-Seq_LNCAP_Human1.42581570
79ELF1_20517297_ChIP-Seq_JURKAT_Human1.41848668
80MYCN_18555785_ChIP-Seq_MESCs_Mouse1.41207153
81CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.40917305
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.38206507
83BCL6_27268052_Chip-Seq_Bcells_Human1.37179341
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.35788893
85* BCOR_27268052_Chip-Seq_Bcells_Human1.34192445
86POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.32509190
87KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.31692317
88* NCOR1_26117541_ChIP-Seq_K562_Human1.31061731
89KDM2B_26808549_Chip-Seq_K562_Human1.30664202
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.30524281
91EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29960370
92KDM2B_26808549_Chip-Seq_JURKAT_Human1.29289541
93CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.28781228
94ZFP281_18757296_ChIP-ChIP_E14_Mouse1.27586735
95EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.27112653
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26962067
97KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.26085777
98SMC4_20622854_ChIP-Seq_HELA_Human1.24591468
99SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24239791
100NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23902145
101PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23826834
102PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22952058
103NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22265993
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.21934125
105ELK1_19687146_ChIP-ChIP_HELA_Human1.21555433
106ATF3_27146783_Chip-Seq_COLON_Human1.21083677
107ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.20009104
108RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.19733524
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19546895
110IRF8_21731497_ChIP-ChIP_J774_Mouse1.17751114
111MAF_26560356_Chip-Seq_TH1_Human1.17267654
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16971097
113CREB1_26743006_Chip-Seq_LNCaP_Human1.16279089
114TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16116200
115GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15846891
116TFEB_21752829_ChIP-Seq_HELA_Human1.15416941
117TP53_22127205_ChIP-Seq_IMR90_Human1.15211016
118RUNX1_22412390_ChIP-Seq_EML_Mouse1.15191039
119ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.15047250
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14727839
121KDM5A_27292631_Chip-Seq_BREAST_Human1.14192738
122STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13884886
123CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13711372
124* VDR_24763502_ChIP-Seq_THP-1_Human1.13625936
125* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.11903025
126UTX_26944678_Chip-Seq_JUKART_Human1.11029336
127STAT6_21828071_ChIP-Seq_BEAS2B_Human1.11004451
128POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10340801
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10049980
130ERG_21242973_ChIP-ChIP_JURKAT_Human1.09834655
131CLOCK_20551151_ChIP-Seq_293T_Human1.09631435
132TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09340865
133TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09340445
134SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07842413
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07745172
136P300_27058665_Chip-Seq_ZR-75-30cells_Human1.07422026
137ESR2_21235772_ChIP-Seq_MCF-7_Human1.07352287
138DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07252463
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07213540
140MYB_26560356_Chip-Seq_TH2_Human1.07204888
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.06365132
142CTCF_26484167_Chip-Seq_Bcells_Mouse1.06109582
143CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04888031
144KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04650574
145* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.04147558
146NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02576105
147VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02243170
148DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02174193
149BRD4_27068464_Chip-Seq_AML-cells_Mouse1.01701366
150CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01607576
151MYB_26560356_Chip-Seq_TH1_Human1.01559550
152CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98795729
153KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98499960
154MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97701628
155MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97230471
156GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92875517
157MAF_26560356_Chip-Seq_TH2_Human0.91753959
158HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.91183702
159TCF7_22412390_ChIP-Seq_EML_Mouse0.91027908
160ELK3_25401928_ChIP-Seq_HUVEC_Human0.90041499
161BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.89253017
162TP63_19390658_ChIP-ChIP_HaCaT_Human0.87891814
163POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87421426

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.18293474
2MP0002396_abnormal_hematopoietic_system3.77321018
3MP0005058_abnormal_lysosome_morphology3.57368088
4MP0010094_abnormal_chromosome_stability3.35088808
5MP0004957_abnormal_blastocyst_morpholog3.22061262
6MP0003111_abnormal_nucleus_morphology3.14439400
7MP0003077_abnormal_cell_cycle2.93407182
8MP0008057_abnormal_DNA_replication2.86287987
9MP0003705_abnormal_hypodermis_morpholog2.85280940
10MP0008260_abnormal_autophagy2.61804222
11MP0000490_abnormal_crypts_of2.45754679
12MP0008058_abnormal_DNA_repair2.45025810
13MP0005451_abnormal_body_composition2.40550405
14MP0008007_abnormal_cellular_replicative2.39026776
15MP0001835_abnormal_antigen_presentation2.33479931
16MP0001545_abnormal_hematopoietic_system2.28848406
17MP0005397_hematopoietic_system_phenotyp2.28848406
18MP0001849_ear_inflammation2.26166668
19MP0003191_abnormal_cellular_cholesterol2.25206987
20MP0004808_abnormal_hematopoietic_stem2.18595315
21MP0009333_abnormal_splenocyte_physiolog2.16738321
22MP0003763_abnormal_thymus_physiology2.15635443
23MP0000685_abnormal_immune_system2.12600721
24MP0009785_altered_susceptibility_to2.09662396
25MP0006054_spinal_hemorrhage2.09539786
26MP0010352_gastrointestinal_tract_polyps2.08031198
27MP0005671_abnormal_response_to2.02134908
28MP0002398_abnormal_bone_marrow1.96704636
29MP0009840_abnormal_foam_cell1.94367348
30MP0003436_decreased_susceptibility_to1.85183365
31MP0002722_abnormal_immune_system1.77471897
32MP0008932_abnormal_embryonic_tissue1.72965349
33MP0005025_abnormal_response_to1.72481350
34MP0000689_abnormal_spleen_morphology1.70565433
35MP0005075_abnormal_melanosome_morpholog1.70487116
36MP0003300_gastrointestinal_ulcer1.66116658
37MP0005174_abnormal_tail_pigmentation1.65356901
38MP0002420_abnormal_adaptive_immunity1.64199056
39MP0000465_gastrointestinal_hemorrhage1.63400943
40MP0001819_abnormal_immune_cell1.62239749
41MP0000350_abnormal_cell_proliferation1.62086909
42MP0005464_abnormal_platelet_physiology1.61087717
43MP0002019_abnormal_tumor_incidence1.60388517
44MP0002429_abnormal_blood_cell1.59200741
45MP0001800_abnormal_humoral_immune1.59066270
46MP0000716_abnormal_immune_system1.58542419
47MP0008438_abnormal_cutaneous_collagen1.57617912
48MP0002166_altered_tumor_susceptibility1.57129588
49MP0004185_abnormal_adipocyte_glucose1.56844744
50MP0003453_abnormal_keratinocyte_physiol1.55757556
51MP0002452_abnormal_antigen_presenting1.55421865
52MP0000858_altered_metastatic_potential1.54703851
53MP0002877_abnormal_melanocyte_morpholog1.54676593
54MP0004858_abnormal_nervous_system1.54564992
55MP0000703_abnormal_thymus_morphology1.52987602
56MP0005000_abnormal_immune_tolerance1.51297104
57MP0002723_abnormal_immune_serum1.51198565
58MP0001853_heart_inflammation1.48026180
59MP0003279_aneurysm1.46236885
60MP0010307_abnormal_tumor_latency1.40946784
61MP0003091_abnormal_cell_migration1.40238229
62MP0000313_abnormal_cell_death1.40228447
63MP0002405_respiratory_system_inflammati1.38826789
64MP0001730_embryonic_growth_arrest1.38499700
65MP0010155_abnormal_intestine_physiology1.38286231
66MP0002796_impaired_skin_barrier1.37721696
67MP0003724_increased_susceptibility_to1.37145040
68MP0002148_abnormal_hypersensitivity_rea1.34540476
69MP0002998_abnormal_bone_remodeling1.34191350
70MP0002419_abnormal_innate_immunity1.33863918
71MP0009278_abnormal_bone_marrow1.32942906
72MP0003786_premature_aging1.32479310
73MP0002006_tumorigenesis1.32427462
74MP0005501_abnormal_skin_physiology1.28263077
75MP0001958_emphysema1.26333995
76MP0002060_abnormal_skin_morphology1.21658803
77MP0000678_abnormal_parathyroid_gland1.21224188
78MP0003866_abnormal_defecation1.20068178
79MP0005390_skeleton_phenotype1.19062334
80MP0005666_abnormal_adipose_tissue1.18410758
81MP0003123_paternal_imprinting1.17267485
82MP0002254_reproductive_system_inflammat1.17155775
83MP0003183_abnormal_peptide_metabolism1.16037016
84MP0003329_amyloid_beta_deposits1.14532984
85MP0003075_altered_response_to1.13120029
86MP0002132_abnormal_respiratory_system1.12296001
87MP0002080_prenatal_lethality1.11810893
88MP0004510_myositis1.11434647
89MP0005387_immune_system_phenotype1.10947454
90MP0001790_abnormal_immune_system1.10947454
91MP0006082_CNS_inflammation1.10253906
92MP0003172_abnormal_lysosome_physiology1.09438806
93MP0001873_stomach_inflammation1.09137451
94MP0010234_abnormal_vibrissa_follicle1.08463059
95MP0002095_abnormal_skin_pigmentation1.06047347
96MP0009379_abnormal_foot_pigmentation1.05569086
97MP0001697_abnormal_embryo_size1.04475157
98MP0003567_abnormal_fetal_cardiomyocyte1.02734639
99MP0005375_adipose_tissue_phenotype1.02357682
100MP0001845_abnormal_inflammatory_respons1.00018052
101MP0005257_abnormal_intraocular_pressure0.98128696
102MP0005023_abnormal_wound_healing0.97357680
103MP0002933_joint_inflammation0.97199552
104MP0001542_abnormal_bone_strength0.96887673
105MP0000681_abnormal_thyroid_gland0.95423107
106MP0009384_cardiac_valve_regurgitation0.92014302
107MP0009931_abnormal_skin_appearance0.91855165
108MP0004782_abnormal_surfactant_physiolog0.91670135
109MP0001672_abnormal_embryogenesis/_devel0.90331845
110MP0005380_embryogenesis_phenotype0.90331845
111MP0004147_increased_porphyrin_level0.90294791
112MP0003795_abnormal_bone_structure0.90262766
113MP0000733_abnormal_muscle_development0.90036954
114MP0000358_abnormal_cell_content/0.88787382
115MP0000604_amyloidosis0.88035101
116MP0000477_abnormal_intestine_morphology0.87362762
117MP0001216_abnormal_epidermal_layer0.87062683
118MP0001851_eye_inflammation0.86436688
119MP0003984_embryonic_growth_retardation0.86158892
120MP0000767_abnormal_smooth_muscle0.86144678
121MP0000003_abnormal_adipose_tissue0.86015575
122MP0003186_abnormal_redox_activity0.85561846
123MP0002086_abnormal_extraembryonic_tissu0.85376371
124MP0003656_abnormal_erythrocyte_physiolo0.82704020
125MP0003303_peritoneal_inflammation0.82631590
126MP0003566_abnormal_cell_adhesion0.82479853
127MP0003448_altered_tumor_morphology0.82374282
128MP0002088_abnormal_embryonic_growth/wei0.82352934
129MP0005083_abnormal_biliary_tract0.81180970
130MP0000343_altered_response_to0.80447591
131MP0001533_abnormal_skeleton_physiology0.80066986
132MP0004264_abnormal_extraembryonic_tissu0.79888220
133MP0004272_abnormal_basement_membrane0.77571254
134MP0002085_abnormal_embryonic_tissue0.77264569
135MP0008469_abnormal_protein_level0.76999356
136MP0006292_abnormal_olfactory_placode0.70108142
137MP0005076_abnormal_cell_differentiation0.68002564
138MP0004947_skin_inflammation0.67846615
139MP0001986_abnormal_taste_sensitivity0.67568478
140MP0001348_abnormal_lacrimal_gland0.67207184
141MP0000015_abnormal_ear_pigmentation0.65983379
142MP0004197_abnormal_fetal_growth/weight/0.65310334
143MP0002084_abnormal_developmental_patter0.63919862
144MP0005384_cellular_phenotype0.63395978
145MP0000371_diluted_coat_color0.62720245
146MP0002075_abnormal_coat/hair_pigmentati0.62370145
147MP0001293_anophthalmia0.61971124
148MP0005621_abnormal_cell_physiology0.61448376

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.08462599
2Abnormal number of erythroid precursors (HP:0012131)5.04287321
3Aplastic anemia (HP:0001915)4.97726007
4Reticulocytopenia (HP:0001896)4.81320774
5Thrombocytosis (HP:0001894)4.58415822
6Colon cancer (HP:0003003)3.41112953
7Type I transferrin isoform profile (HP:0003642)3.38262105
8Elevated erythrocyte sedimentation rate (HP:0003565)3.33488046
9Pallor (HP:0000980)3.27121218
10Petechiae (HP:0000967)3.25777839
11Broad face (HP:0000283)3.18174702
12IgM deficiency (HP:0002850)3.17512071
13Selective tooth agenesis (HP:0001592)3.11592556
14Oral leukoplakia (HP:0002745)3.09791949
15Dysostosis multiplex (HP:0000943)3.05958451
16Birth length less than 3rd percentile (HP:0003561)3.05855292
17Thoracic kyphosis (HP:0002942)3.03625815
18Reduced antithrombin III activity (HP:0001976)2.98918047
19Cervical subluxation (HP:0003308)2.95302407
20Premature rupture of membranes (HP:0001788)2.91770078
21Chronic otitis media (HP:0000389)2.91269249
22Distal upper limb amyotrophy (HP:0007149)2.88413158
23Upper limb amyotrophy (HP:0009129)2.88413158
24Recurrent abscess formation (HP:0002722)2.87717299
25J-shaped sella turcica (HP:0002680)2.87031009
26Abnormality of the thoracic spine (HP:0100711)2.80904987
27Myositis (HP:0100614)2.78201160
28Macrocytic anemia (HP:0001972)2.76591841
29Hyperacusis (HP:0010780)2.74500283
30Aplasia/Hypoplasia of the sacrum (HP:0008517)2.74102288
31Distal lower limb amyotrophy (HP:0008944)2.71304569
32Microretrognathia (HP:0000308)2.70201065
33Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.70193815
34Abnormal protein N-linked glycosylation (HP:0012347)2.70193815
35Abnormal protein glycosylation (HP:0012346)2.70193815
36Abnormal glycosylation (HP:0012345)2.70193815
37Agnosia (HP:0010524)2.69964927
38Vertebral compression fractures (HP:0002953)2.68411851
3911 pairs of ribs (HP:0000878)2.68091977
40Myelodysplasia (HP:0002863)2.64635744
41Loss of speech (HP:0002371)2.56181778
42Interstitial pulmonary disease (HP:0006530)2.55759088
43Abnormality of T cell physiology (HP:0011840)2.53915764
44Rough bone trabeculation (HP:0100670)2.52285175
45Distal lower limb muscle weakness (HP:0009053)2.52228432
46Pancytopenia (HP:0001876)2.50332002
47Protrusio acetabuli (HP:0003179)2.49526798
48Obstructive lung disease (HP:0006536)2.48594791
49Chronic obstructive pulmonary disease (HP:0006510)2.48594791
50Poikiloderma (HP:0001029)2.47559488
51B lymphocytopenia (HP:0010976)2.46453918
52Abnormality of B cell number (HP:0010975)2.46453918
53Amaurosis fugax (HP:0100576)2.44599360
54Joint stiffness (HP:0001387)2.39624268
55Achilles tendon contracture (HP:0001771)2.39563063
56Pustule (HP:0200039)2.39443034
57Increased cerebral lipofuscin (HP:0011813)2.38110590
58Lymphoma (HP:0002665)2.37404712
59Stridor (HP:0010307)2.36556056
60Polygenic inheritance (HP:0010982)2.36236488
61Abnormality of liposaccharide metabolism (HP:0010968)2.35243922
62Abnormality of glycosphingolipid metabolism (HP:0004343)2.35243922
63Abnormality of glycolipid metabolism (HP:0010969)2.35243922
64Basal cell carcinoma (HP:0002671)2.34651242
65Atrophic scars (HP:0001075)2.34620727
66Prolonged bleeding time (HP:0003010)2.31155976
67Premature graying of hair (HP:0002216)2.29614416
68Absent thumb (HP:0009777)2.29182337
69Chromsome breakage (HP:0040012)2.28698931
70Hand muscle atrophy (HP:0009130)2.28449468
71Bone marrow hypocellularity (HP:0005528)2.25834945
72Degeneration of anterior horn cells (HP:0002398)2.25749806
73Abnormality of the anterior horn cell (HP:0006802)2.25749806
74Ependymoma (HP:0002888)2.24019147
75Urinary glycosaminoglycan excretion (HP:0003541)2.23113520
76Mucopolysacchariduria (HP:0008155)2.23113520
77Medulloblastoma (HP:0002885)2.22489794
78Increased connective tissue (HP:0009025)2.22441238
79Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21229622
80Abnormality of polysaccharide metabolism (HP:0011012)2.21229622
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21229622
82Recurrent bacterial skin infections (HP:0005406)2.20950143
83Increased neuronal autofluorescent lipopigment (HP:0002074)2.20900051
84Long palpebral fissure (HP:0000637)2.20178476
85Hepatosplenomegaly (HP:0001433)2.19669737
86Thin bony cortex (HP:0002753)2.18425381
87Trismus (HP:0000211)2.16501338
88Spinal cord lesions (HP:0100561)2.16452735
89Syringomyelia (HP:0003396)2.16452735
90Breast hypoplasia (HP:0003187)2.15622502
91Increased IgE level (HP:0003212)2.14399218
92Amyloidosis (HP:0011034)2.14278562
93Acute lymphatic leukemia (HP:0006721)2.13487036
94Abnormality of the preputium (HP:0100587)2.11387564
95Pulmonary fibrosis (HP:0002206)2.10221301
96Gastrointestinal inflammation (HP:0004386)2.08301660
97Abnormality of T cells (HP:0002843)2.07839110
98Spondylolisthesis (HP:0003302)2.06724596
99Abnormality of the distal phalanges of the toes (HP:0010182)2.06478262
100Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06273239
101Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06273239
102Cholecystitis (HP:0001082)2.05551460
103Abnormal gallbladder physiology (HP:0012438)2.05551460
104Muscle fiber atrophy (HP:0100295)2.04649624
105Hypertriglyceridemia (HP:0002155)2.04609152
106Chromosomal breakage induced by crosslinking agents (HP:0003221)2.04280956
107Recurrent viral infections (HP:0004429)2.02962808
108Abnormality of the heme biosynthetic pathway (HP:0010472)2.01534219
109Multiple enchondromatosis (HP:0005701)2.01300317
110Flat acetabular roof (HP:0003180)2.00891071
111Colitis (HP:0002583)2.00732035
112Neoplasm of the pancreas (HP:0002894)2.00580903
113Hypertensive crisis (HP:0100735)2.00143222
114Cerebral aneurysm (HP:0004944)1.99815642
115Panhypogammaglobulinemia (HP:0003139)1.97996788
116Abnormality of DNA repair (HP:0003254)1.97923902
117Slender long bone (HP:0003100)1.97909611
118Recurrent bronchitis (HP:0002837)1.97119708
119Meckel diverticulum (HP:0002245)1.96990622
120Abnormality of the Achilles tendon (HP:0005109)1.96542641
121Severe visual impairment (HP:0001141)1.96513976
122Abnormality of chromosome stability (HP:0003220)1.96152695
123Mitral regurgitation (HP:0001653)1.95855281
124Abnormality of reticulocytes (HP:0004312)1.94362392
125Fragile skin (HP:0001030)1.93489147
126Abnormality of the ileum (HP:0001549)1.93343108
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.92187643
128Biconcave vertebral bodies (HP:0004586)1.91771187
129Abnormality of cells of the lymphoid lineage (HP:0012140)1.91706240
130Ulnar bowing (HP:0003031)1.91031087
131Poor head control (HP:0002421)1.90773751
132Emphysema (HP:0002097)1.89773933
133Gastrointestinal stroma tumor (HP:0100723)1.89636901
134Agammaglobulinemia (HP:0004432)1.89599690
135Eczematoid dermatitis (HP:0000976)1.89474719
136Epistaxis (HP:0000421)1.87644994
137IgG deficiency (HP:0004315)1.87635978
138Flattened epiphyses (HP:0003071)1.87389604
139Entropion (HP:0000621)1.87206147
140Squamous cell carcinoma (HP:0002860)1.87098025
141Obstructive sleep apnea (HP:0002870)1.86994873
142Difficulty climbing stairs (HP:0003551)1.86180153
143Short clavicles (HP:0000894)1.85761342
144Blue sclerae (HP:0000592)1.84520159
145Type 2 muscle fiber atrophy (HP:0003554)1.84467587
146Mediastinal lymphadenopathy (HP:0100721)1.84337663
147Lymphopenia (HP:0001888)1.84274509
148Premature loss of primary teeth (HP:0006323)1.84126766
149Carpal bone hypoplasia (HP:0001498)1.83291381
150Abnormal platelet function (HP:0011869)1.83066065
151Impaired platelet aggregation (HP:0003540)1.83066065
152Tracheoesophageal fistula (HP:0002575)1.82985128
153Albinism (HP:0001022)1.81175754
154Acute myeloid leukemia (HP:0004808)1.80996878
155Cellulitis (HP:0100658)1.80699657
156Recurrent fungal infections (HP:0002841)1.79796686
157Abnormality of the lumbar spine (HP:0100712)1.79675902
158Inflammation of the large intestine (HP:0002037)1.79347308
159Easy fatigability (HP:0003388)1.78941276
160Abnormality of macrophages (HP:0004311)1.78652139
161Neuronal loss in central nervous system (HP:0002529)1.78645070
162Nuclear cataract (HP:0100018)1.78337694
163Fatigue (HP:0012378)1.77945677
164Aplasia/Hypoplasia of the uvula (HP:0010293)1.77566229
165Abnormality of the nasal mucosa (HP:0000433)1.77147392
166Abnormality of the columella (HP:0009929)1.77005311
167Patellar aplasia (HP:0006443)1.75844247
168Abnormality of the prostate (HP:0008775)1.74953781
169Short nail (HP:0001799)1.74179946
170Nasal polyposis (HP:0100582)1.74150370
171Cellular immunodeficiency (HP:0005374)1.73828590
172Abnormal number of incisors (HP:0011064)1.73379152
173Gingivitis (HP:0000230)1.73302119
174Asplenia (HP:0001746)1.73072139
175Aplasia/Hypoplasia of the clavicles (HP:0006710)1.72183199
176Hypergammaglobulinemia (HP:0010702)1.72156348
177Chest pain (HP:0100749)1.72044025
178Optic nerve coloboma (HP:0000588)1.71641647
179Elbow flexion contracture (HP:0002987)1.71513993
180Meningitis (HP:0001287)1.70937115
181Gastrointestinal dysmotility (HP:0002579)1.70824942
182Axonal loss (HP:0003447)1.70095333
183Growth hormone excess (HP:0000845)1.69101863
184Abnormal trabecular bone morphology (HP:0100671)1.68723027
185Disproportionate tall stature (HP:0001519)1.68666859
186Vacuolated lymphocytes (HP:0001922)1.67893973

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WEE13.48409199
2PRPF4B3.18138497
3BUB12.97328984
4CDC72.93465405
5SMG12.88571479
6SIK12.81192455
7NME22.79213280
8STK162.58906482
9MAP4K12.56916254
10EEF2K2.41922972
11PIM22.25320393
12TESK22.14006884
13NEK22.10365974
14FLT32.06608066
15EIF2AK31.94385835
16KIT1.89422531
17EIF2AK11.84874416
18ACVR1B1.80436870
19RPS6KB21.80133327
20ICK1.79524710
21KDR1.75093159
22SCYL21.69811039
23VRK11.69657866
24BTK1.69561873
25CDK71.68685153
26ERN11.66334925
27RIPK41.62992159
28BRSK21.59172094
29MAP2K31.57862948
30TEC1.55898684
31TGFBR11.52501121
32MAP3K111.52442517
33ARAF1.48984205
34ZAP701.45273371
35PAK41.43766586
36PASK1.43746958
37DYRK31.43405465
38PKN21.43158280
39MAP3K131.43129307
40SRPK11.40548716
41RPS6KA41.40513646
42ATR1.36008494
43MAPKAPK31.34095191
44LRRK21.28677305
45STK101.25744333
46PRKD21.25433035
47TSSK61.23364157
48TTN1.21324781
49TLK11.21066603
50JAK31.19728807
51BLK1.19529852
52IRAK41.17756904
53MAP3K81.17538457
54EPHB11.17342529
55TNK21.16439584
56PLK11.16409792
57TYK21.14745987
58PTK61.13142362
59AURKB1.13047543
60MST1R1.10606424
61CSF1R1.09754501
62CDK41.07845285
63MAP3K141.07043320
64NEK11.06676639
65RPS6KA21.05641329
66MAP3K61.03344196
67TBK11.02892156
68BCKDK1.01765775
69MAP3K100.99972600
70PIM10.96743196
71PLK40.95040783
72TTK0.94910218
73SIK30.94801348
74RIPK10.94372309
75RPS6KL10.94246139
76RPS6KC10.94246139
77MATK0.92860558
78MKNK10.91819668
79HIPK20.89031042
80TXK0.85595180
81MARK20.85002145
82PTK20.82458784
83FGFR40.81563938
84LMTK20.81021251
85DAPK10.79875506
86MAP2K20.79508821
87LIMK10.77619296
88CDC42BPA0.77269427
89MAP3K10.76619268
90SYK0.76024443
91CCNB10.75331929
92AURKA0.75170706
93TESK10.74504865
94BRSK10.73816985
95CDK80.73453263
96IRAK20.72410360
97CSK0.72264842
98CHEK20.71878474
99BMX0.70500231
100CDK190.70440851
101MOS0.70000963
102TGFBR20.66908104
103SIK20.66321037
104IKBKB0.66300188
105TAOK20.66257238
106PDGFRA0.65622624
107LYN0.65014912
108MTOR0.64393948
109STK40.59685878
110BRAF0.59257644
111PDPK10.58844871
112LCK0.58740363
113GRK60.58679971
114IRAK30.58645817
115PRKG20.58536544
116CLK10.58470886
117NLK0.56973111
118TRIB30.56274350
119NTRK10.55763497
120ILK0.54557358
121CHEK10.54254992
122VRK20.54215591
123MAPKAPK20.53615949
124DAPK30.53614431
125PAK10.52208886
126CDK120.51850975
127CSNK2A20.50640400
128CSNK2A10.50496477
129ABL20.49314283
130DYRK1B0.49279882
131MAPK150.48979365
132RAF10.47586722
133MAP2K60.47376463
134IKBKE0.46866831
135EPHA20.46865454
136EIF2AK20.46767356
137MAPK70.46562793
138TAOK10.46518538
139MAP3K120.45780419
140MAPK110.44814553
141CDK20.44258314
142MAP3K30.42967310
143MAP3K70.42919065
144MAPK40.42362025
145FES0.41440178
146ITK0.41324785
147CDK60.40323494
148RPS6KA60.38547789
149CAMKK20.38533494
150HCK0.38025190

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.37551655
2Mismatch repair_Homo sapiens_hsa034304.13590410
3Ribosome_Homo sapiens_hsa030104.12876978
4Base excision repair_Homo sapiens_hsa034103.21283047
5Spliceosome_Homo sapiens_hsa030402.75311549
6Homologous recombination_Homo sapiens_hsa034402.72534734
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.60613373
8Nucleotide excision repair_Homo sapiens_hsa034202.56358244
9RNA polymerase_Homo sapiens_hsa030202.51834144
10Proteasome_Homo sapiens_hsa030502.51641553
11Pyrimidine metabolism_Homo sapiens_hsa002402.38320737
12RNA transport_Homo sapiens_hsa030132.12517605
13One carbon pool by folate_Homo sapiens_hsa006702.06115794
14Cell cycle_Homo sapiens_hsa041102.05625038
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.94082381
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75855165
17Fanconi anemia pathway_Homo sapiens_hsa034601.75419399
18Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.75338691
19Non-homologous end-joining_Homo sapiens_hsa034501.55580157
20Antigen processing and presentation_Homo sapiens_hsa046121.53401917
21RNA degradation_Homo sapiens_hsa030181.51054373
22Lysosome_Homo sapiens_hsa041421.50905470
23Primary immunodeficiency_Homo sapiens_hsa053401.48382738
24VEGF signaling pathway_Homo sapiens_hsa043701.47527813
25p53 signaling pathway_Homo sapiens_hsa041151.43983277
26Central carbon metabolism in cancer_Homo sapiens_hsa052301.40939664
27Pancreatic cancer_Homo sapiens_hsa052121.29196054
28N-Glycan biosynthesis_Homo sapiens_hsa005101.28570130
29Salmonella infection_Homo sapiens_hsa051321.27208448
30Herpes simplex infection_Homo sapiens_hsa051681.26885943
31Protein export_Homo sapiens_hsa030601.23774823
32Non-small cell lung cancer_Homo sapiens_hsa052231.23657846
33TNF signaling pathway_Homo sapiens_hsa046681.16896536
34Sulfur relay system_Homo sapiens_hsa041221.16272353
35Purine metabolism_Homo sapiens_hsa002301.15462261
36Pentose phosphate pathway_Homo sapiens_hsa000301.12746262
37Basal transcription factors_Homo sapiens_hsa030221.08228023
38Hepatitis C_Homo sapiens_hsa051601.06813882
39Neurotrophin signaling pathway_Homo sapiens_hsa047221.06193502
40Epstein-Barr virus infection_Homo sapiens_hsa051691.05276496
41Other glycan degradation_Homo sapiens_hsa005111.04798184
42Folate biosynthesis_Homo sapiens_hsa007901.03476239
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01867089
44Leishmaniasis_Homo sapiens_hsa051401.00168891
45Legionellosis_Homo sapiens_hsa051340.99015910
46Measles_Homo sapiens_hsa051620.96735218
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.96509434
48T cell receptor signaling pathway_Homo sapiens_hsa046600.95678109
49Autoimmune thyroid disease_Homo sapiens_hsa053200.95661877
50Graft-versus-host disease_Homo sapiens_hsa053320.93585217
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92685776
52Endocytosis_Homo sapiens_hsa041440.90168645
53Hematopoietic cell lineage_Homo sapiens_hsa046400.89971515
54mRNA surveillance pathway_Homo sapiens_hsa030150.88076905
55Amoebiasis_Homo sapiens_hsa051460.86850655
56Thyroid cancer_Homo sapiens_hsa052160.83163004
57Systemic lupus erythematosus_Homo sapiens_hsa053220.83139573
58Shigellosis_Homo sapiens_hsa051310.81791986
59Endometrial cancer_Homo sapiens_hsa052130.81639312
60Focal adhesion_Homo sapiens_hsa045100.81498022
61Viral carcinogenesis_Homo sapiens_hsa052030.79533013
62Apoptosis_Homo sapiens_hsa042100.77849617
63Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77790257
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76658643
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76627534
66NF-kappa B signaling pathway_Homo sapiens_hsa040640.76625660
67HTLV-I infection_Homo sapiens_hsa051660.75645397
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.73687164
69Phagosome_Homo sapiens_hsa041450.73663814
70Vibrio cholerae infection_Homo sapiens_hsa051100.73100763
71Intestinal immune network for IgA production_Homo sapiens_hsa046720.72862982
72mTOR signaling pathway_Homo sapiens_hsa041500.72846451
73ErbB signaling pathway_Homo sapiens_hsa040120.70945854
74Acute myeloid leukemia_Homo sapiens_hsa052210.69920219
75Galactose metabolism_Homo sapiens_hsa000520.67661672
76Chemokine signaling pathway_Homo sapiens_hsa040620.67570346
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.67434459
78Hepatitis B_Homo sapiens_hsa051610.65953953
79Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.65806678
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.64806967
81Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.64696665
82Proteoglycans in cancer_Homo sapiens_hsa052050.64279247
83Prolactin signaling pathway_Homo sapiens_hsa049170.63686100
84Prion diseases_Homo sapiens_hsa050200.63484130
85B cell receptor signaling pathway_Homo sapiens_hsa046620.63200348
86Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.62405239
87Choline metabolism in cancer_Homo sapiens_hsa052310.61969508
88Small cell lung cancer_Homo sapiens_hsa052220.61732141
89Insulin signaling pathway_Homo sapiens_hsa049100.61300028
90Renal cell carcinoma_Homo sapiens_hsa052110.60777883
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.60724567
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.60011060
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59373452
94Influenza A_Homo sapiens_hsa051640.58936684
95GnRH signaling pathway_Homo sapiens_hsa049120.58202592
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56019122
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.55071776
98Biosynthesis of amino acids_Homo sapiens_hsa012300.55051316
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55013688
100Cysteine and methionine metabolism_Homo sapiens_hsa002700.54899733
101Glycosaminoglycan degradation_Homo sapiens_hsa005310.54521663
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.54195884
103Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53737102
104Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53001132
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.52320183
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.52021367
107Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51871932
108Renin-angiotensin system_Homo sapiens_hsa046140.51260251
109Asthma_Homo sapiens_hsa053100.50024861
110NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47116795
111Allograft rejection_Homo sapiens_hsa053300.45600978
112Toxoplasmosis_Homo sapiens_hsa051450.44402017
113Chronic myeloid leukemia_Homo sapiens_hsa052200.43774707
114Toll-like receptor signaling pathway_Homo sapiens_hsa046200.42856018
115Viral myocarditis_Homo sapiens_hsa054160.42285553
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41010521
117Notch signaling pathway_Homo sapiens_hsa043300.39062327
118Glutathione metabolism_Homo sapiens_hsa004800.38414589
119Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38344692
120Malaria_Homo sapiens_hsa051440.37928247
121Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37919387
122Fructose and mannose metabolism_Homo sapiens_hsa000510.37846365
123Osteoclast differentiation_Homo sapiens_hsa043800.37772143
124Pertussis_Homo sapiens_hsa051330.37261261
125Colorectal cancer_Homo sapiens_hsa052100.37161114
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36832060
127Selenocompound metabolism_Homo sapiens_hsa004500.36531118
128Bladder cancer_Homo sapiens_hsa052190.35131328
129Leukocyte transendothelial migration_Homo sapiens_hsa046700.34242816
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33955061
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.33307019
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.32955955
133Platelet activation_Homo sapiens_hsa046110.32534855
134Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31007943
135Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.30787940
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30624694
137Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29290141
138Tuberculosis_Homo sapiens_hsa051520.28855193
139HIF-1 signaling pathway_Homo sapiens_hsa040660.27806829

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