ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.42164456
2	respiratory chain complex IV assembly (GO:0008535)	5.11209034
3	cytochrome complex assembly (GO:0017004)	4.56508084
4	regulation of nuclear cell cycle DNA replication (GO:0033262)	4.18564755
5	DNA deamination (GO:0045006)	3.84959913
6	detection of light stimulus involved in sensory perception (GO:0050962)	3.78392314
7	detection of light stimulus involved in visual perception (GO:0050908)	3.78392314
8	fucose catabolic process (GO:0019317)	3.68841815
9	L-fucose metabolic process (GO:0042354)	3.68841815
10	L-fucose catabolic process (GO:0042355)	3.68841815
11	cellular response to ATP (GO:0071318)	3.68342534
12	regulation of neurotransmitter uptake (GO:0051580)	3.62527945
13	protein complex biogenesis (GO:0070271)	3.58370906
14	response to pheromone (GO:0019236)	3.57485631
15	platelet dense granule organization (GO:0060155)	3.54394867
16	water-soluble vitamin biosynthetic process (GO:0042364)	3.47598247
17	mitochondrial respiratory chain complex assembly (GO:0033108)	3.44384416
18	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.39266025
19	protein import into peroxisome matrix (GO:0016558)	3.28297231
20	NADH dehydrogenase complex assembly (GO:0010257)	3.27257295
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.27257295
22	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.27257295
23	regulation of cilium movement (GO:0003352)	3.23779806
24	piRNA metabolic process (GO:0034587)	3.08624101
25	negative regulation of telomere maintenance (GO:0032205)	3.08504758
26	mannosylation (GO:0097502)	3.04929136
27	cellular ketone body metabolic process (GO:0046950)	3.02694002
28	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.97441055
29	regulation of action potential (GO:0098900)	2.93710722
30	ubiquinone biosynthetic process (GO:0006744)	2.92846606
31	indole-containing compound catabolic process (GO:0042436)	2.90932242
32	indolalkylamine catabolic process (GO:0046218)	2.90932242
33	tryptophan catabolic process (GO:0006569)	2.90932242
34	protein-cofactor linkage (GO:0018065)	2.90510903
35	DNA strand renaturation (GO:0000733)	2.90405875
36	negative regulation of mast cell activation (GO:0033004)	2.86457396
37	indolalkylamine metabolic process (GO:0006586)	2.86253314
38	peptidyl-histidine modification (GO:0018202)	2.80323266
39	cellular biogenic amine catabolic process (GO:0042402)	2.79999806
40	amine catabolic process (GO:0009310)	2.79999806
41	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.76523505
42	negative regulation of cell aging (GO:0090344)	2.74489390
43	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73535749
44	inositol phosphate catabolic process (GO:0071545)	2.72137856
45	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.70249735
46	protein K6-linked ubiquitination (GO:0085020)	2.69911081
47	arginine metabolic process (GO:0006525)	2.68155447
48	ketone body metabolic process (GO:1902224)	2.66813289
49	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.66481002
50	polyol catabolic process (GO:0046174)	2.66402768
51	adaptation of signaling pathway (GO:0023058)	2.65803842
52	positive regulation of guanylate cyclase activity (GO:0031284)	2.65263133
53	DNA methylation involved in gamete generation (GO:0043046)	2.61579500
54	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.61477358
55	reciprocal DNA recombination (GO:0035825)	2.60684112
56	reciprocal meiotic recombination (GO:0007131)	2.60684112
57	tRNA modification (GO:0006400)	2.60343754
58	protein polyglutamylation (GO:0018095)	2.59900263
59	preassembly of GPI anchor in ER membrane (GO:0016254)	2.59858428
60	negative regulation of protein oligomerization (GO:0032460)	2.59204407
61	positive regulation of prostaglandin secretion (GO:0032308)	2.59094186
62	regulation of microtubule-based movement (GO:0060632)	2.57840602
63	replication fork processing (GO:0031297)	2.57697898
64	synapsis (GO:0007129)	2.57287471
65	ubiquinone metabolic process (GO:0006743)	2.57021108
66	nucleotide transmembrane transport (GO:1901679)	2.54209366
67	intracellular protein transmembrane import (GO:0044743)	2.52549098
68	nucleoside transmembrane transport (GO:1901642)	2.51739399
69	positive regulation of defense response to virus by host (GO:0002230)	2.51054926
70	phosphorylated carbohydrate dephosphorylation (GO:0046838)	2.50801982
71	inositol phosphate dephosphorylation (GO:0046855)	2.50801982
72	tRNA processing (GO:0008033)	2.50084891
73	termination of RNA polymerase III transcription (GO:0006386)	2.49282410
74	transcription elongation from RNA polymerase III promoter (GO:0006385)	2.49282410
75	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.47643883
76	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.47643883
77	rRNA modification (GO:0000154)	2.46978942
78	pseudouridine synthesis (GO:0001522)	2.46749438
79	protein localization to cilium (GO:0061512)	2.46707899
80	maturation of 5.8S rRNA (GO:0000460)	2.46002221
81	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.44941146
82	meiotic chromosome segregation (GO:0045132)	2.43774372
83	cornea development in camera-type eye (GO:0061303)	2.43286750
84	recombinational repair (GO:0000725)	2.43054752
85	mitotic cell cycle arrest (GO:0071850)	2.42366001
86	rRNA methylation (GO:0031167)	2.42075307
87	arginine catabolic process (GO:0006527)	2.41551994
88	exogenous drug catabolic process (GO:0042738)	2.41353864
89	regulation of synapse structural plasticity (GO:0051823)	2.41136265
90	phosphatidylglycerol biosynthetic process (GO:0006655)	2.41024637
91	regulation of memory T cell differentiation (GO:0043380)	2.40385260
92	S-adenosylmethionine metabolic process (GO:0046500)	2.39176947
93	double-strand break repair via homologous recombination (GO:0000724)	2.38887642
94	negative regulation of calcium ion transport into cytosol (GO:0010523)	2.38479747
95	tryptophan metabolic process (GO:0006568)	2.38129949
96	regulation of guanylate cyclase activity (GO:0031282)	2.37968235
97	neuronal action potential (GO:0019228)	2.36776828
98	synaptic transmission, cholinergic (GO:0007271)	2.36739495
99	glycerophospholipid catabolic process (GO:0046475)	2.33847800
100	regulation of synaptic transmission, dopaminergic (GO:0032225)	2.33490875

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.41817832
2	EZH2_22144423_ChIP-Seq_EOC_Human	3.57477558
3	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.82169466
4	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	2.69304190
5	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.62578599
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.60249902
7	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.50357364
8	GABP_17652178_ChIP-ChIP_JURKAT_Human	2.48375694
9	VDR_22108803_ChIP-Seq_LS180_Human	2.35574683
10	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.33083435
11	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.30984336
12	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.18019684
13	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.16827835
14	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	2.11736544
15	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.01996318
16	ERA_21632823_ChIP-Seq_H3396_Human	1.94974936
17	TP53_22573176_ChIP-Seq_HFKS_Human	1.94523299
18	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.93343895
19	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.85795990
20	VDR_23849224_ChIP-Seq_CD4+_Human	1.80843933
21	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.76000140
22	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.73970989
23	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.70915568
24	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.67169461
25	IGF1R_20145208_ChIP-Seq_DFB_Human	1.66230501
26	MYC_18940864_ChIP-ChIP_HL60_Human	1.65965692
27	REST_21632747_ChIP-Seq_MESCs_Mouse	1.61166835
28	TAF2_19829295_ChIP-Seq_ESCs_Human	1.58791603
29	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.58167766
30	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.57383939
31	EWS_26573619_Chip-Seq_HEK293_Human	1.56393400
32	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.54592743
33	FOXP3_21729870_ChIP-Seq_TREG_Human	1.53735017
34	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.53060395
35	NANOG_20526341_ChIP-Seq_ESCs_Human	1.51207716
36	E2F1_20622854_ChIP-Seq_HELA_Human	1.50153722
37	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.47744697
38	MYC_19829295_ChIP-Seq_ESCs_Human	1.46563641
39	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.44646930
40	OCT4_20526341_ChIP-Seq_ESCs_Human	1.44645700
41	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.43971696
42	BCL6_27268052_Chip-Seq_Bcells_Human	1.42798193
43	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.40746727
44	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.37929479
45	PHF8_20622854_ChIP-Seq_HELA_Human	1.33521518
46	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.32023262
47	P53_21459846_ChIP-Seq_SAOS-2_Human	1.31835740
48	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.31415369
49	RAC3_21632823_ChIP-Seq_H3396_Human	1.29374616
50	NCOR_22424771_ChIP-Seq_293T_Human	1.29332146
51	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27548754
52	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27548754
53	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.26254217
54	BCOR_27268052_Chip-Seq_Bcells_Human	1.26179951
55	P68_20966046_ChIP-Seq_HELA_Human	1.25851921
56	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.22565597
57	GABP_19822575_ChIP-Seq_HepG2_Human	1.22190754
58	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.21993473
59	KDM5A_27292631_Chip-Seq_BREAST_Human	1.21146986
60	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	1.21138898
61	FUS_26573619_Chip-Seq_HEK293_Human	1.19948786
62	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.17059727
63	HOXB7_26014856_ChIP-Seq_BT474_Human	1.15348884
64	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13494182
65	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.12747977
66	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.12517857
67	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	1.10664788
68	P300_27268052_Chip-Seq_Bcells_Human	1.10432861
69	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10173804
70	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10173804
71	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.08510998
72	GBX2_23144817_ChIP-Seq_PC3_Human	1.07965164
73	CTCF_20526341_ChIP-Seq_ESCs_Human	1.07496492
74	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.06824961
75	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.06119581
76	AR_20517297_ChIP-Seq_VCAP_Human	1.03494514
77	GATA3_26560356_Chip-Seq_TH2_Human	1.01999491
78	BCAT_22108803_ChIP-Seq_LS180_Human	1.01246290
79	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.00216562
80	IRF1_19129219_ChIP-ChIP_H3396_Human	0.98016348
81	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97823931
82	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.97315539
83	OCT4_19829295_ChIP-Seq_ESCs_Human	0.96635177
84	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.96219216
85	FOXP1_21924763_ChIP-Seq_HESCs_Human	0.95997881
86	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.95028621
87	TAF15_26573619_Chip-Seq_HEK293_Human	0.94289254
88	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	0.93834928
89	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.93593355
90	GATA3_21867929_ChIP-Seq_TH1_Mouse	0.92722991
91	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.92158560
92	CBP_20019798_ChIP-Seq_JUKART_Human	0.92158560
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.92140098
94	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.92135834
95	DROSHA_22980978_ChIP-Seq_HELA_Human	0.90023159
96	ER_23166858_ChIP-Seq_MCF-7_Human	0.89629072
97	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	0.88435675
98	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.87912021
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.87882953
100	ELF1_20517297_ChIP-Seq_JURKAT_Human	0.86389908

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0001986_abnormal_taste_sensitivity	3.87373989
2	MP0005174_abnormal_tail_pigmentation	3.04833911
3	MP0001968_abnormal_touch/_nociception	2.69683928
4	MP0008877_abnormal_DNA_methylation	2.61110446
5	MP0003195_calcinosis	2.54776208
6	MP0003646_muscle_fatigue	2.47137591
7	MP0004043_abnormal_pH_regulation	2.28536243
8	MP0003136_yellow_coat_color	2.27709402
9	MP0005423_abnormal_somatic_nervous	2.24447551
10	MP0005551_abnormal_eye_electrophysiolog	2.19466373
11	MP0009046_muscle_twitch	2.17658685
12	MP0002254_reproductive_system_inflammat	2.07766576
13	MP0005645_abnormal_hypothalamus_physiol	2.06135809
14	MP0002837_dystrophic_cardiac_calcinosis	2.03144714
15	MP0008875_abnormal_xenobiotic_pharmacok	2.02600711
16	MP0009745_abnormal_behavioral_response	1.94757674
17	MP0002736_abnormal_nociception_after	1.93743253
18	MP0002638_abnormal_pupillary_reflex	1.90119707
19	MP0002876_abnormal_thyroid_physiology	1.88580384
20	MP0008872_abnormal_physiological_respon	1.80501014
21	MP0006082_CNS_inflammation	1.73582138
22	MP0003787_abnormal_imprinting	1.67406998
23	MP0000015_abnormal_ear_pigmentation	1.60835006
24	MP0001919_abnormal_reproductive_system	1.60237698
25	MP0005167_abnormal_blood-brain_barrier	1.59649577
26	MP0006072_abnormal_retinal_apoptosis	1.55344656
27	MP0001501_abnormal_sleep_pattern	1.53061183
28	MP0002909_abnormal_adrenal_gland	1.50691593
29	MP0002272_abnormal_nervous_system	1.48743672
30	MP0001529_abnormal_vocalization	1.48437021
31	MP0002064_seizures	1.47569077
32	MP0003718_maternal_effect	1.46581747
33	MP0003806_abnormal_nucleotide_metabolis	1.44455873
34	MP0002735_abnormal_chemical_nociception	1.42599154
35	MP0001970_abnormal_pain_threshold	1.42210009
36	MP0005253_abnormal_eye_physiology	1.41678522
37	MP0001905_abnormal_dopamine_level	1.39147107
38	MP0001756_abnormal_urination	1.38366610
39	MP0002163_abnormal_gland_morphology	1.34961084
40	MP0002277_abnormal_respiratory_mucosa	1.33581362
41	MP0004142_abnormal_muscle_tone	1.32682225
42	MP0004133_heterotaxia	1.30836603
43	MP0005646_abnormal_pituitary_gland	1.28040079
44	MP0008995_early_reproductive_senescence	1.26747235
45	MP0001188_hyperpigmentation	1.24823702
46	MP0005389_reproductive_system_phenotype	1.24549965
47	MP0002234_abnormal_pharynx_morphology	1.22865886
48	MP0005332_abnormal_amino_acid	1.22174429
49	MP0002572_abnormal_emotion/affect_behav	1.19754981
50	MP0001486_abnormal_startle_reflex	1.17327471
51	MP0002693_abnormal_pancreas_physiology	1.16333439
52	MP0005171_absent_coat_pigmentation	1.16245825
53	MP0008058_abnormal_DNA_repair	1.16005830
54	MP0004885_abnormal_endolymph	1.15690736
55	MP0003011_delayed_dark_adaptation	1.14674638
56	MP0001764_abnormal_homeostasis	1.13555635
57	MP0002557_abnormal_social/conspecific_i	1.13196869
58	MP0000631_abnormal_neuroendocrine_gland	1.12531013
59	MP0004147_increased_porphyrin_level	1.11583551
60	MP0006036_abnormal_mitochondrial_physio	1.09614713
61	MP0005671_abnormal_response_to	1.08885239
62	MP0006035_abnormal_mitochondrial_morpho	1.08691035
63	MP0003635_abnormal_synaptic_transmissio	1.08563189
64	MP0001873_stomach_inflammation	1.07821172
65	MP0005084_abnormal_gallbladder_morpholo	1.06657257
66	MP0002063_abnormal_learning/memory/cond	1.04238171
67	MP0006292_abnormal_olfactory_placode	1.03794277
68	MP0001984_abnormal_olfaction	1.03554794
69	MP0000569_abnormal_digit_pigmentation	1.01326836
70	MP0005379_endocrine/exocrine_gland_phen	0.99622842
71	MP0002102_abnormal_ear_morphology	0.99223170
72	MP0003786_premature_aging	0.98079196
73	MP0002733_abnormal_thermal_nociception	0.95919967
74	MP0006276_abnormal_autonomic_nervous	0.94836191
75	MP0003283_abnormal_digestive_organ	0.94008888
76	MP0002160_abnormal_reproductive_system	0.93976657
77	MP0001502_abnormal_circadian_rhythm	0.92938886
78	MP0003878_abnormal_ear_physiology	0.92640852
79	MP0005377_hearing/vestibular/ear_phenot	0.92640852
80	MP0004742_abnormal_vestibular_system	0.92545438
81	MP0004924_abnormal_behavior	0.91496338
82	MP0005386_behavior/neurological_phenoty	0.91496338
83	MP0002928_abnormal_bile_duct	0.88920080
84	MP0010386_abnormal_urinary_bladder	0.86895609
85	MP0002067_abnormal_sensory_capabilities	0.86301928
86	MP0005410_abnormal_fertilization	0.86232755
87	MP0002229_neurodegeneration	0.84424177
88	MP0000538_abnormal_urinary_bladder	0.81724273
89	MP0001485_abnormal_pinna_reflex	0.80655532
90	MP0000372_irregular_coat_pigmentation	0.79817954
91	MP0010329_abnormal_lipoprotein_level	0.79776621
92	MP0002734_abnormal_mechanical_nocicepti	0.79537592
93	MP0000470_abnormal_stomach_morphology	0.79104462
94	MP0003121_genomic_imprinting	0.78549710
95	MP0001944_abnormal_pancreas_morphology	0.77663647
96	MP0009764_decreased_sensitivity_to	0.77328810
97	MP0003698_abnormal_male_reproductive	0.76432814
98	MP0000427_abnormal_hair_cycle	0.76142046
99	MP0004019_abnormal_vitamin_homeostasis	0.75195725
100	MP0002210_abnormal_sex_determination	0.74067381

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Congenital stationary night blindness (HP:0007642)	4.46353025
2	Attenuation of retinal blood vessels (HP:0007843)	3.74787585
3	Pancreatic cysts (HP:0001737)	3.39348672
4	Abnormal drinking behavior (HP:0030082)	3.26716825
5	Polydipsia (HP:0001959)	3.26716825
6	Pancreatic fibrosis (HP:0100732)	3.15006908
7	Bony spicule pigmentary retinopathy (HP:0007737)	3.10738023
8	Molar tooth sign on MRI (HP:0002419)	3.04284748
9	Abnormality of midbrain morphology (HP:0002418)	3.04284748
10	Rib fusion (HP:0000902)	2.89292484
11	Abnormal rod and cone electroretinograms (HP:0008323)	2.86932474
12	Nephronophthisis (HP:0000090)	2.86558248
13	Pendular nystagmus (HP:0012043)	2.73686153
14	Type II lissencephaly (HP:0007260)	2.68804115
15	Mitochondrial inheritance (HP:0001427)	2.67650472
16	True hermaphroditism (HP:0010459)	2.65737728
17	Absent thumb (HP:0009777)	2.60215493
18	Increased CSF lactate (HP:0002490)	2.59040238
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.58490206
20	Abolished electroretinogram (ERG) (HP:0000550)	2.54661348
21	Intestinal fistula (HP:0100819)	2.53202702
22	Chronic hepatic failure (HP:0100626)	2.47914181
23	Mesangial abnormality (HP:0001966)	2.45767165
24	Ketoacidosis (HP:0001993)	2.44155870
25	Polyuria (HP:0000103)	2.42969103
26	Acute necrotizing encephalopathy (HP:0006965)	2.42192841
27	Hepatocellular necrosis (HP:0001404)	2.40853186
28	Lipid accumulation in hepatocytes (HP:0006561)	2.40713787
29	Ketosis (HP:0001946)	2.36809212
30	Tubular atrophy (HP:0000092)	2.36195415
31	Autoimmune thrombocytopenia (HP:0001973)	2.30903005
32	Abnormality of the renal medulla (HP:0100957)	2.29138567
33	Hepatic necrosis (HP:0002605)	2.29054592
34	Abnormality of alanine metabolism (HP:0010916)	2.24050754
35	Hyperalaninemia (HP:0003348)	2.24050754
36	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.24050754
37	Decreased central vision (HP:0007663)	2.23924280
38	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.22484716
39	Optic disc pallor (HP:0000543)	2.21897985
40	Hypoplasia of the pons (HP:0012110)	2.21390329
41	Hyperinsulinemic hypoglycemia (HP:0000825)	2.20218215
42	Acute encephalopathy (HP:0006846)	2.16835782
43	Hypoalbuminemia (HP:0003073)	2.16629762
44	Abnormal albumin level (HP:0012116)	2.16629762
45	Progressive macrocephaly (HP:0004481)	2.15612163
46	Hypothermia (HP:0002045)	2.15573367
47	Increased hepatocellular lipid droplets (HP:0006565)	2.15085296
48	Medial flaring of the eyebrow (HP:0010747)	2.13954005
49	Abnormality of the renal cortex (HP:0011035)	2.13829554
50	Patellar aplasia (HP:0006443)	2.12981946
51	Renal Fanconi syndrome (HP:0001994)	2.12568372
52	Cerebellar dysplasia (HP:0007033)	2.12197239
53	Abnormal mitochondria in muscle tissue (HP:0008316)	2.11056755
54	Methylmalonic aciduria (HP:0012120)	2.10288361
55	Abnormality of the pons (HP:0007361)	2.10001534
56	Abnormal biliary tract physiology (HP:0012439)	2.06446854
57	Bile duct proliferation (HP:0001408)	2.06446854
58	Testicular atrophy (HP:0000029)	2.00701946
59	Aplasia/Hypoplasia of the patella (HP:0006498)	1.98148459
60	Increased serum lactate (HP:0002151)	1.96690697
61	Stomatitis (HP:0010280)	1.95156251
62	Hyperventilation (HP:0002883)	1.93877352
63	Progressive microcephaly (HP:0000253)	1.93863199
64	Severe muscular hypotonia (HP:0006829)	1.93638007
65	Cystic liver disease (HP:0006706)	1.93177394
66	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.93085746
67	Methylmalonic acidemia (HP:0002912)	1.91845709
68	Abnormal urine output (HP:0012590)	1.91229787
69	Sclerocornea (HP:0000647)	1.87049495
70	Severe visual impairment (HP:0001141)	1.86805977
71	Chorioretinal atrophy (HP:0000533)	1.86725664
72	Congenital hepatic fibrosis (HP:0002612)	1.86402869
73	Ectopic kidney (HP:0000086)	1.85846229
74	Intestinal atresia (HP:0011100)	1.85259713
75	Abnormal protein glycosylation (HP:0012346)	1.84607656
76	Abnormal glycosylation (HP:0012345)	1.84607656
77	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.84607656
78	Abnormal protein N-linked glycosylation (HP:0012347)	1.84607656
79	Lactic acidosis (HP:0003128)	1.83097314
80	Large for gestational age (HP:0001520)	1.82252857
81	Birth length less than 3rd percentile (HP:0003561)	1.81767266
82	Lissencephaly (HP:0001339)	1.81312916
83	Poor head control (HP:0002421)	1.81297205
84	Gaze-evoked nystagmus (HP:0000640)	1.80854533
85	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.78328955
86	Inability to walk (HP:0002540)	1.77357331
87	Polyphagia (HP:0002591)	1.74739635
88	Type I transferrin isoform profile (HP:0003642)	1.73808596
89	Tachypnea (HP:0002789)	1.72498785
90	Hypomagnesemia (HP:0002917)	1.71724705
91	Lethargy (HP:0001254)	1.69390495
92	Concave nail (HP:0001598)	1.68868554
93	Rectovaginal fistula (HP:0000143)	1.67925488
94	Rectal fistula (HP:0100590)	1.67925488
95	Retinitis pigmentosa (HP:0000510)	1.66915934
96	3-Methylglutaconic aciduria (HP:0003535)	1.66414031
97	Progressive inability to walk (HP:0002505)	1.65951968
98	Hemiparesis (HP:0001269)	1.64719006
99	Male pseudohermaphroditism (HP:0000037)	1.64299483
100	Neoplasm of the adrenal cortex (HP:0100641)	1.63678051

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.58943108
2	WNK4	4.06941099
3	ZAK	3.54687962
4	ADRBK2	3.19778678
5	PINK1	2.97838543
6	BMPR1B	2.73441557
7	TLK1	2.73350378
8	MAP4K2	2.53948606
9	WNK3	2.49021679
10	GRK1	2.44929636
11	DAPK2	2.40664319
12	ACVR1B	2.23342411
13	STK39	2.15364663
14	MAPK15	1.94407965
15	BCKDK	1.93061471
16	INSRR	1.72521035
17	CCNB1	1.66940407
18	MAPK13	1.61213576
19	NUAK1	1.43255726
20	TRIM28	1.40549049
21	CSNK1G3	1.36187981
22	NTRK3	1.27128471
23	CSNK1G2	1.21623607
24	STK24	1.19734305
25	PHKG1	1.18225864
26	PHKG2	1.18225864
27	OXSR1	1.13428777
28	CSNK1G1	1.10429622
29	CAMKK2	1.09428326
30	PAK3	1.07882759
31	CSNK1A1L	1.06551137
32	CASK	1.04773816
33	DYRK2	1.03662274
34	TNK2	0.99561132
35	ADRBK1	0.97776338
36	PRKCQ	0.96621118
37	MST4	0.95437489
38	PRKCG	0.94791097
39	TXK	0.91247696
40	CAMK1D	0.89146248
41	WNK1	0.88827278
42	MAP2K6	0.88384064
43	CAMK1	0.88284347
44	TAOK3	0.87352662
45	MKNK2	0.86763121
46	PDK2	0.84542570
47	CHEK2	0.83260204
48	STK16	0.81556017
49	VRK2	0.72789731
50	PASK	0.71266121
51	MAP2K7	0.71233598
52	IKBKB	0.70915555
53	TGFBR1	0.70224651
54	PRKCI	0.69605432
55	VRK1	0.68784458
56	TNIK	0.68271928
57	CAMKK1	0.67976660
58	MAP3K4	0.66626873
59	MUSK	0.65656388
60	BLK	0.63822625
61	CAMK4	0.62962095
62	MAP3K2	0.57735544
63	MAPKAPK3	0.57487332
64	STK11	0.56799299
65	GRK6	0.56742250
66	NTRK2	0.54645989
67	MAPKAPK5	0.54399437
68	PRKCE	0.53627563
69	RPS6KA5	0.52298807
70	MINK1	0.50721214
71	DYRK3	0.49797874
72	CSNK1A1	0.46450649
73	PLK3	0.46314194
74	ATR	0.45415390
75	RPS6KA6	0.45311667
76	PLK2	0.43679571
77	SYK	0.43243793
78	DAPK1	0.42176290
79	PRKCZ	0.41753191
80	CSNK1D	0.40165494
81	CAMK1G	0.39819567
82	MAP3K11	0.38942521
83	PLK1	0.38302850
84	SIK2	0.37628208
85	PRKACA	0.36566992
86	CDC7	0.36190674
87	KIT	0.35511358
88	NME1	0.35270009
89	PKN1	0.35059944
90	GRK7	0.33790035
91	PAK6	0.33530306
92	PRKCH	0.32642721
93	MARK1	0.31686143
94	PRKCA	0.30946315
95	ITK	0.30192593
96	MARK3	0.29917681
97	EPHA4	0.29375859
98	LYN	0.28794414
99	FGFR2	0.26701429
100	PRKAA1	0.25691584

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	3.35490453
2	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.34057665
3	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	3.22776378
4	Phototransduction_Homo sapiens_hsa04744	2.75755058
5	Selenocompound metabolism_Homo sapiens_hsa00450	2.57003850
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.55467789
7	RNA polymerase_Homo sapiens_hsa03020	2.38890378
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.36409432
9	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.27825943
10	Fanconi anemia pathway_Homo sapiens_hsa03460	2.07497444
11	Sulfur relay system_Homo sapiens_hsa04122	2.03871838
12	Nitrogen metabolism_Homo sapiens_hsa00910	2.01439392
13	Homologous recombination_Homo sapiens_hsa03440	1.91163079
14	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.88613749
15	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.86543421
16	Parkinsons disease_Homo sapiens_hsa05012	1.85237004
17	Nicotine addiction_Homo sapiens_hsa05033	1.78012466
18	Linoleic acid metabolism_Homo sapiens_hsa00591	1.77148222
19	One carbon pool by folate_Homo sapiens_hsa00670	1.69876814
20	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.67410773
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.53160595
22	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50424802
23	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.47551217
24	Butanoate metabolism_Homo sapiens_hsa00650	1.42844536
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40633842
26	Peroxisome_Homo sapiens_hsa04146	1.31108819
27	Basal transcription factors_Homo sapiens_hsa03022	1.30847738
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.28245109
29	Pyrimidine metabolism_Homo sapiens_hsa00240	1.27824886
30	Regulation of autophagy_Homo sapiens_hsa04140	1.25535189
31	Alzheimers disease_Homo sapiens_hsa05010	1.24000812
32	Huntingtons disease_Homo sapiens_hsa05016	1.23670572
33	Taste transduction_Homo sapiens_hsa04742	1.18875425
34	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.13479836
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.12043416
36	Caffeine metabolism_Homo sapiens_hsa00232	1.09836825
37	Non-homologous end-joining_Homo sapiens_hsa03450	1.07165123
38	Insulin secretion_Homo sapiens_hsa04911	1.07043291
39	Proteasome_Homo sapiens_hsa03050	1.06888836
40	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.05779887
41	Tryptophan metabolism_Homo sapiens_hsa00380	1.05317482
42	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.01922864
43	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.01479174
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.00513603
45	Folate biosynthesis_Homo sapiens_hsa00790	0.94379477
46	Protein export_Homo sapiens_hsa03060	0.93149248
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92567491
48	Olfactory transduction_Homo sapiens_hsa04740	0.92424954
49	Purine metabolism_Homo sapiens_hsa00230	0.92359267
50	Type I diabetes mellitus_Homo sapiens_hsa04940	0.91469942
51	RNA degradation_Homo sapiens_hsa03018	0.90905652
52	Sphingolipid metabolism_Homo sapiens_hsa00600	0.90153077
53	Morphine addiction_Homo sapiens_hsa05032	0.89550017
54	Sulfur metabolism_Homo sapiens_hsa00920	0.89373401
55	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.87905169
56	Circadian entrainment_Homo sapiens_hsa04713	0.82643202
57	Lysosome_Homo sapiens_hsa04142	0.81022593
58	Mineral absorption_Homo sapiens_hsa04978	0.80471179
59	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80089197
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.78096359
61	Metabolic pathways_Homo sapiens_hsa01100	0.74672653
62	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.74372573
63	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.74332996
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.72165975
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.71217822
66	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.70823386
67	Asthma_Homo sapiens_hsa05310	0.69286400
68	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.69014123
69	Primary immunodeficiency_Homo sapiens_hsa05340	0.68174469
70	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.59109066
71	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.58678725
72	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.57963025
73	ABC transporters_Homo sapiens_hsa02010	0.57145221
74	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.56836925
75	GABAergic synapse_Homo sapiens_hsa04727	0.55356450
76	Chemical carcinogenesis_Homo sapiens_hsa05204	0.51229646
77	Calcium signaling pathway_Homo sapiens_hsa04020	0.51204772
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.51069946
79	Arginine biosynthesis_Homo sapiens_hsa00220	0.49305709
80	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.49185636
81	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.48351025
82	Glycerolipid metabolism_Homo sapiens_hsa00561	0.47971911
83	Dopaminergic synapse_Homo sapiens_hsa04728	0.46450165
84	Propanoate metabolism_Homo sapiens_hsa00640	0.46006083
85	Glutamatergic synapse_Homo sapiens_hsa04724	0.45851830
86	Salivary secretion_Homo sapiens_hsa04970	0.45366744
87	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.43412832
88	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.43212853
89	Amphetamine addiction_Homo sapiens_hsa05031	0.41057228
90	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.40451159
91	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.40321268
92	Rheumatoid arthritis_Homo sapiens_hsa05323	0.39485184
93	Steroid biosynthesis_Homo sapiens_hsa00100	0.38912255
94	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.37146711
95	Allograft rejection_Homo sapiens_hsa05330	0.36259729
96	Circadian rhythm_Homo sapiens_hsa04710	0.36096852
97	Cocaine addiction_Homo sapiens_hsa05030	0.36041164
98	Serotonergic synapse_Homo sapiens_hsa04726	0.35517315
99	Retinol metabolism_Homo sapiens_hsa00830	0.34916163
100	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.34183796

MFSD13A

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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