MFSD14A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)8.01274042
2axon ensheathment in central nervous system (GO:0032291)8.01274042
3fatty acid elongation (GO:0030497)6.18612699
4nuclear pore complex assembly (GO:0051292)5.57945988
5nuclear pore organization (GO:0006999)5.10593427
6ensheathment of neurons (GO:0007272)4.88478986
7axon ensheathment (GO:0008366)4.88478986
8pore complex assembly (GO:0046931)4.88348556
9myelination (GO:0042552)4.84470134
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.74610900
11cholesterol biosynthetic process (GO:0006695)4.40047148
12long-chain fatty acid biosynthetic process (GO:0042759)4.18811499
13ribosome assembly (GO:0042255)4.18408471
14sterol biosynthetic process (GO:0016126)4.00462548
15myelin maintenance (GO:0043217)3.98273866
16mitotic metaphase plate congression (GO:0007080)3.93096137
17negative regulation of neurotransmitter secretion (GO:0046929)3.83290441
18glycerophospholipid catabolic process (GO:0046475)3.82564056
19regulation of exit from mitosis (GO:0007096)3.72884680
20preassembly of GPI anchor in ER membrane (GO:0016254)3.68818346
21magnesium ion transport (GO:0015693)3.68283226
22monoubiquitinated protein deubiquitination (GO:0035520)3.62568096
23regulation of meiosis I (GO:0060631)3.60802265
24isoprenoid biosynthetic process (GO:0008299)3.56071563
25somatic hypermutation of immunoglobulin genes (GO:0016446)3.50731118
26somatic diversification of immune receptors via somatic mutation (GO:0002566)3.50731118
27histone H2B ubiquitination (GO:0033523)3.43930189
28microtubule polymerization or depolymerization (GO:0031109)3.40275972
29negative regulation of neurotransmitter transport (GO:0051589)3.38045796
30negative regulation of meiosis (GO:0045835)3.31211433
31DNA double-strand break processing (GO:0000729)3.30460158
32somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.29988245
33isotype switching (GO:0045190)3.29988245
34somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.29988245
35positive regulation of chromosome segregation (GO:0051984)3.24937204
36GPI anchor biosynthetic process (GO:0006506)3.22755017
37double-strand break repair via nonhomologous end joining (GO:0006303)3.18987683
38non-recombinational repair (GO:0000726)3.18987683
39negative regulation of inclusion body assembly (GO:0090084)3.18813223
40regulation of spindle organization (GO:0090224)3.18311293
41purine nucleobase biosynthetic process (GO:0009113)3.16316046
42regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.14888683
43metaphase plate congression (GO:0051310)3.14835407
44regulation of spindle checkpoint (GO:0090231)3.13282660
45regulation of RNA export from nucleus (GO:0046831)3.12158103
46oligodendrocyte differentiation (GO:0048709)3.08364187
47L-amino acid import (GO:0043092)3.08283645
48GPI anchor metabolic process (GO:0006505)3.05588094
49asymmetric protein localization (GO:0008105)3.05217988
50spindle assembly involved in mitosis (GO:0090307)3.05050761
51long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.05050341
52spermatid nucleus differentiation (GO:0007289)3.03286780
53regulation of collateral sprouting (GO:0048670)2.99272856
54regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.98255720
55regulation of T cell chemotaxis (GO:0010819)2.95487215
56positive regulation of T cell chemotaxis (GO:0010820)2.95487215
57mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.91417736
58positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.91417736
59regulation of mRNA 3-end processing (GO:0031440)2.90896618
60response to lipoprotein particle (GO:0055094)2.88387277
61response to redox state (GO:0051775)2.88167179
62establishment of mitochondrion localization (GO:0051654)2.88051186
63cellular protein complex localization (GO:0034629)2.87347705
64negative regulation of DNA recombination (GO:0045910)2.85759791
65transcription elongation from RNA polymerase III promoter (GO:0006385)2.85637529
66termination of RNA polymerase III transcription (GO:0006386)2.85637529
67mitochondrial DNA replication (GO:0006264)2.84700373
68sphingosine metabolic process (GO:0006670)2.83986547
69piRNA metabolic process (GO:0034587)2.83871685
70regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.83266817
71regulation of mitotic spindle checkpoint (GO:1903504)2.83266817
72alditol phosphate metabolic process (GO:0052646)2.83064893
73regulation of centriole replication (GO:0046599)2.82152086
74mitotic sister chromatid cohesion (GO:0007064)2.81043151
75somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.79380371
76somatic cell DNA recombination (GO:0016444)2.79380371
77synapsis (GO:0007129)2.78464658
78RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.77876952
79response to methylmercury (GO:0051597)2.77807827
80N-terminal protein amino acid modification (GO:0031365)2.77234958
81positive regulation of autophagy (GO:0010508)2.77013708
82histone mRNA catabolic process (GO:0071044)2.75168090
83negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.74225458
84negative regulation of macroautophagy (GO:0016242)2.73881093
85germ cell migration (GO:0008354)2.73698800
86CENP-A containing nucleosome assembly (GO:0034080)2.72911485
87glycosylceramide metabolic process (GO:0006677)2.72608858
88DNA replication initiation (GO:0006270)2.71180592
89nucleobase biosynthetic process (GO:0046112)2.71130626
90positive regulation of mRNA 3-end processing (GO:0031442)2.70268493
91regulation of T-helper 1 cell differentiation (GO:0045625)2.69830518
92positive regulation of macroautophagy (GO:0016239)2.69609611
93somatic diversification of immune receptors (GO:0002200)2.69054070
94transcription elongation from RNA polymerase I promoter (GO:0006362)2.68909566
95postreplication repair (GO:0006301)2.68363518
96regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.68083524
97lung-associated mesenchyme development (GO:0060484)2.68039624
98long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.67871891
99somatic recombination of immunoglobulin gene segments (GO:0016447)2.65934925
100negative regulation of execution phase of apoptosis (GO:1900118)2.64907737
101establishment of integrated proviral latency (GO:0075713)2.64540034
102microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.64383934
103phosphatidylserine acyl-chain remodeling (GO:0036150)2.63649879
104amyloid precursor protein metabolic process (GO:0042982)2.60791393
105maturation of 5.8S rRNA (GO:0000460)2.60764284
106male meiosis I (GO:0007141)2.60079236
107regulation of nucleobase-containing compound transport (GO:0032239)2.59772805
108ER overload response (GO:0006983)2.59541749
109UDP-N-acetylglucosamine metabolic process (GO:0006047)2.59409409
110spindle checkpoint (GO:0031577)2.58388115
111L-serine metabolic process (GO:0006563)2.58171252
112positive regulation of mitotic sister chromatid separation (GO:1901970)2.57754364
113positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.57754364
114positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57754364
115response to X-ray (GO:0010165)2.57553554
116intestinal epithelial cell development (GO:0060576)2.57441364
117microtubule depolymerization (GO:0007019)2.56925961
118DNA ligation (GO:0006266)2.56526187
119response to pheromone (GO:0019236)2.56497023
120protein palmitoylation (GO:0018345)2.56051796
121regulation of chromosome segregation (GO:0051983)2.55935824
122histone H2A ubiquitination (GO:0033522)2.55254029
123protein K6-linked ubiquitination (GO:0085020)2.54974584
124DNA replication checkpoint (GO:0000076)2.54547818
125pyrimidine-containing compound transmembrane transport (GO:0072531)2.54462352
126vitamin transmembrane transport (GO:0035461)2.53943070
127somatic diversification of immunoglobulins (GO:0016445)2.53188368
128autophagic vacuole assembly (GO:0000045)2.52935369
129DNA replication-dependent nucleosome assembly (GO:0006335)2.52737348
130DNA replication-dependent nucleosome organization (GO:0034723)2.52737348
131phosphatidylserine metabolic process (GO:0006658)2.52082623
132chromatin remodeling at centromere (GO:0031055)2.51937495
133L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.51494953
134meiotic cell cycle (GO:0051321)2.50387784
135mRNA modification (GO:0016556)2.49832252
136neural tube formation (GO:0001841)2.49111426
137meiosis I (GO:0007127)2.48816834
138fusion of sperm to egg plasma membrane (GO:0007342)2.48784626
139positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.48242763
140attachment of spindle microtubules to kinetochore (GO:0008608)2.47594807
141regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47171719
142regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47171719
143fatty-acyl-CoA biosynthetic process (GO:0046949)2.47060893
144COPII vesicle coating (GO:0048208)2.46986773
145C-terminal protein lipidation (GO:0006501)2.46975813
146rRNA modification (GO:0000154)2.46946974
147transcription initiation from RNA polymerase I promoter (GO:0006361)2.46942545
148histone H2A acetylation (GO:0043968)2.46204655
149termination of RNA polymerase I transcription (GO:0006363)2.46088375
150cell wall macromolecule catabolic process (GO:0016998)2.45645890
151protein K11-linked ubiquitination (GO:0070979)2.45478993
152rRNA catabolic process (GO:0016075)2.45385704
153establishment of chromosome localization (GO:0051303)2.44817106
154regulation of helicase activity (GO:0051095)2.43459689
155photoreceptor cell differentiation (GO:0046530)2.43335128
156eye photoreceptor cell differentiation (GO:0001754)2.43335128
157pre-miRNA processing (GO:0031054)2.43328985
158negative regulation of meiotic cell cycle (GO:0051447)2.43009556
159mitotic spindle checkpoint (GO:0071174)2.42885213
160mitotic nuclear envelope disassembly (GO:0007077)2.42106699
161regulation of fibroblast apoptotic process (GO:2000269)2.41354476
162IMP biosynthetic process (GO:0006188)2.41165309
163protein K11-linked deubiquitination (GO:0035871)2.40816821
164platelet dense granule organization (GO:0060155)2.39804527
165regulation of memory T cell differentiation (GO:0043380)2.36482346
166membrane disassembly (GO:0030397)2.35969305
167nuclear envelope disassembly (GO:0051081)2.35969305
168regulation of translation in response to stress (GO:0043555)2.33352137
169negative regulation of thymocyte apoptotic process (GO:0070244)2.32425468
170negative regulation of mitotic sister chromatid separation (GO:2000816)2.32076513
171negative regulation of sister chromatid segregation (GO:0033046)2.32076513
172negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.32076513
173negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.32076513
174negative regulation of mitotic sister chromatid segregation (GO:0033048)2.32076513
175negative regulation of chromosome segregation (GO:0051985)2.29948007
176histone mRNA metabolic process (GO:0008334)2.29225933
177regulation of mitotic sister chromatid separation (GO:0010965)2.29202565
178regulation of mitotic sister chromatid segregation (GO:0033047)2.29202565
179regulation of sister chromatid segregation (GO:0033045)2.29202565
180mitotic G2/M transition checkpoint (GO:0044818)2.29062509
181regulation of chromatin silencing (GO:0031935)2.27897272
182energy homeostasis (GO:0097009)2.26228420
183DNA catabolic process, exonucleolytic (GO:0000738)2.24931237
184NIK/NF-kappaB signaling (GO:0038061)2.24537947
185regulation of RIG-I signaling pathway (GO:0039535)2.23979821
186histone exchange (GO:0043486)2.23900951
187female gonad development (GO:0008585)2.21274779
188establishment of viral latency (GO:0019043)2.21117074
189histone ubiquitination (GO:0016574)2.19970126
190regulation of sister chromatid cohesion (GO:0007063)2.19936511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.69598335
2E2F7_22180533_ChIP-Seq_HELA_Human4.65818004
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.72104019
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.32662216
5AR_21909140_ChIP-Seq_LNCAP_Human2.95459175
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.88923833
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.79331549
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77142710
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.74629020
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65881307
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60079660
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.56531638
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.53211358
14NOTCH1_21737748_ChIP-Seq_TLL_Human2.49315284
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.31822039
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.29955024
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.28588884
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.20721049
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.20614378
20IGF1R_20145208_ChIP-Seq_DFB_Human2.17940352
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.09333108
22SMAD_19615063_ChIP-ChIP_OVARY_Human2.03524277
23VDR_23849224_ChIP-Seq_CD4+_Human2.00830135
24MYCN_18555785_ChIP-Seq_MESCs_Mouse2.00002196
25FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.97820391
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.93889558
27MYC_19030024_ChIP-ChIP_MESCs_Mouse1.91356529
28KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.88249116
29KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.88249116
30KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.88249116
31TAF15_26573619_Chip-Seq_HEK293_Human1.85841599
32FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.83745315
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82808769
34MYC_19079543_ChIP-ChIP_MESCs_Mouse1.82446590
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.76111728
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.73634145
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.72346430
38MYC_18358816_ChIP-ChIP_MESCs_Mouse1.69666588
39GATA1_26923725_Chip-Seq_HPCs_Mouse1.68814679
40CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.68550896
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.66150425
42STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66069893
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.63811408
44FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.60727931
45MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.60222325
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.59453322
47FLI1_27457419_Chip-Seq_LIVER_Mouse1.57791450
48GATA1_22025678_ChIP-Seq_K562_Human1.47971944
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.47825282
50ELK1_19687146_ChIP-ChIP_HELA_Human1.46774740
51IRF8_21731497_ChIP-ChIP_J774_Mouse1.46287099
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.41929937
53LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.40126985
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.38497914
55ZNF274_21170338_ChIP-Seq_K562_Hela1.37484016
56KAP1_22055183_ChIP-Seq_ESCs_Mouse1.35367171
57MYB_26560356_Chip-Seq_TH2_Human1.34705471
58P300_19829295_ChIP-Seq_ESCs_Human1.34162365
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33440209
60IRF1_19129219_ChIP-ChIP_H3396_Human1.32913198
61SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.31017418
62KDM5A_27292631_Chip-Seq_BREAST_Human1.30888142
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30780820
64PCGF2_27294783_Chip-Seq_ESCs_Mouse1.30302365
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26452942
66SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24886712
67E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24812453
68GABP_19822575_ChIP-Seq_HepG2_Human1.24239170
69POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23868876
70ZFP57_27257070_Chip-Seq_ESCs_Mouse1.23515897
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.22335373
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21813158
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.21751575
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.20790796
75FOXP3_21729870_ChIP-Seq_TREG_Human1.19116978
76E2F1_21310950_ChIP-Seq_MCF-7_Human1.18562025
77RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.18287685
78BP1_19119308_ChIP-ChIP_Hs578T_Human1.18147725
79VDR_22108803_ChIP-Seq_LS180_Human1.17013885
80Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.16973303
81DCP1A_22483619_ChIP-Seq_HELA_Human1.16294676
82STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13183833
83ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.12851120
84EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.12778874
85SOX17_20123909_ChIP-Seq_XEN_Mouse1.12470958
86FUS_26573619_Chip-Seq_HEK293_Human1.11333138
87TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11185255
88BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10713188
89TFEB_21752829_ChIP-Seq_HELA_Human1.10019857
90HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09398540
91EWS_26573619_Chip-Seq_HEK293_Human1.09359072
92FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.08748447
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07534901
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07033269
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.07028522
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.05584001
97CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.05583693
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05521643
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04689056
100SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.04516087
101XRN2_22483619_ChIP-Seq_HELA_Human1.03926759
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03886646
103TCF3_18692474_ChIP-Seq_MESCs_Mouse1.03667297
104SALL4_22934838_ChIP-ChIP_CD34+_Human1.03638659
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.03413771
106CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02737888
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.02535510
108ER_23166858_ChIP-Seq_MCF-7_Human1.01296988
109PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00217994
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.00166071
111GATA3_26560356_Chip-Seq_TH2_Human0.99869861
112MYC_18940864_ChIP-ChIP_HL60_Human0.99345483
113PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98648058
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97980792
115MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.95733996
116PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.94938578
117MYB_21317192_ChIP-Seq_ERMYB_Mouse0.94829929
118AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94597012
119NANOG_18692474_ChIP-Seq_MEFs_Mouse0.94313790
120ZFX_18555785_ChIP-Seq_MESCs_Mouse0.94122172
121TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.94101562
122ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93417369
123SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.92934490
124FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.92821685
125MYB_26560356_Chip-Seq_TH1_Human0.92255382
126NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92006599
127HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91161024
128CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90657323
129NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.89919834
130CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.89500291
131GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88838128
132UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88137096
133SPI1_23547873_ChIP-Seq_NB4_Human0.88092889
134CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87755218
135STAT4_19710469_ChIP-ChIP_TH1__Mouse0.87588095
136MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87415084
137NFE2_27457419_Chip-Seq_LIVER_Mouse0.87368774
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.87368433
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.85853739
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.85569236
141SUZ12_27294783_Chip-Seq_NPCs_Mouse0.85509927
142GATA3_27048872_Chip-Seq_THYMUS_Human0.84853247
143SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.82996570
144NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82449192
145TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80151780
146PHF8_20622853_ChIP-Seq_HELA_Human0.79708975

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.28769586
2MP0000920_abnormal_myelination3.99411472
3MP0006054_spinal_hemorrhage3.40988279
4MP0003693_abnormal_embryo_hatching3.33186079
5MP0003890_abnormal_embryonic-extraembry3.25653757
6MP0003950_abnormal_plasma_membrane3.09201393
7MP0008260_abnormal_autophagy3.04405113
8MP0003136_yellow_coat_color3.03484618
9MP0005410_abnormal_fertilization2.98012808
10MP0000569_abnormal_digit_pigmentation2.89295683
11MP0010352_gastrointestinal_tract_polyps2.73929053
12MP0004885_abnormal_endolymph2.66932260
13MP0005451_abnormal_body_composition2.60858609
14MP0010678_abnormal_skin_adnexa2.60764192
15MP0003718_maternal_effect2.57844479
16MP0000383_abnormal_hair_follicle2.53321248
17MP0003111_abnormal_nucleus_morphology2.46960331
18MP0004957_abnormal_blastocyst_morpholog2.44459177
19MP0003690_abnormal_glial_cell2.41175136
20MP0010094_abnormal_chromosome_stability2.35043738
21MP0003724_increased_susceptibility_to2.33276110
22MP0000462_abnormal_digestive_system2.13873195
23MP0003077_abnormal_cell_cycle2.11700798
24MP0003329_amyloid_beta_deposits2.06379664
25MP0001485_abnormal_pinna_reflex1.96640300
26MP0001929_abnormal_gametogenesis1.91339661
27MP0005171_absent_coat_pigmentation1.90169857
28MP0002166_altered_tumor_susceptibility1.89767520
29MP0008877_abnormal_DNA_methylation1.85657666
30MP0003221_abnormal_cardiomyocyte_apopto1.82280435
31MP0009840_abnormal_foam_cell1.81178856
32MP0001529_abnormal_vocalization1.80486057
33MP0002006_tumorigenesis1.75515154
34MP0001661_extended_life_span1.73954323
35MP0005671_abnormal_response_to1.71524485
36MP0003937_abnormal_limbs/digits/tail_de1.69973276
37MP0003632_abnormal_nervous_system1.66439158
38MP0008932_abnormal_embryonic_tissue1.64418458
39MP0000372_irregular_coat_pigmentation1.64187761
40MP0003634_abnormal_glial_cell1.64100397
41MP0002102_abnormal_ear_morphology1.64065221
42MP0003698_abnormal_male_reproductive1.62131474
43MP0005075_abnormal_melanosome_morpholog1.59370275
44MP0001730_embryonic_growth_arrest1.55265501
45MP0002210_abnormal_sex_determination1.54554630
46MP0001145_abnormal_male_reproductive1.52844410
47MP0003763_abnormal_thymus_physiology1.49251535
48MP0001293_anophthalmia1.49239528
49MP0006082_CNS_inflammation1.49238418
50MP0000465_gastrointestinal_hemorrhage1.47795299
51MP0008058_abnormal_DNA_repair1.45596448
52MP0005058_abnormal_lysosome_morphology1.45236799
53MP0004742_abnormal_vestibular_system1.41936000
54MP0003943_abnormal_hepatobiliary_system1.41100527
55MP0000647_abnormal_sebaceous_gland1.40752792
56MP0006035_abnormal_mitochondrial_morpho1.37518745
57MP0001851_eye_inflammation1.35630139
58MP0001835_abnormal_antigen_presentation1.35522764
59MP0003195_calcinosis1.32471257
60MP0003806_abnormal_nucleotide_metabolis1.30703312
61MP0004264_abnormal_extraembryonic_tissu1.29223117
62MP0003300_gastrointestinal_ulcer1.28692516
63MP0000653_abnormal_sex_gland1.28396992
64MP0005000_abnormal_immune_tolerance1.28107405
65MP0004808_abnormal_hematopoietic_stem1.27209136
66MP0004270_analgesia1.26824588
67MP0003121_genomic_imprinting1.26154870
68MP0002148_abnormal_hypersensitivity_rea1.25890865
69MP0003303_peritoneal_inflammation1.25526744
70MP0003172_abnormal_lysosome_physiology1.24110644
71MP0001905_abnormal_dopamine_level1.24036597
72MP0003123_paternal_imprinting1.22460497
73MP0003938_abnormal_ear_development1.18311584
74MP0008995_early_reproductive_senescence1.17689001
75MP0009697_abnormal_copulation1.17391610
76MP0001299_abnormal_eye_distance/1.17088734
77MP0002398_abnormal_bone_marrow1.16866537
78MP0004043_abnormal_pH_regulation1.16401299
79MP0009785_altered_susceptibility_to1.15140620
80MP0002138_abnormal_hepatobiliary_system1.13857203
81MP0008007_abnormal_cellular_replicative1.13822075
82MP0000689_abnormal_spleen_morphology1.12485353
83MP0000604_amyloidosis1.09749235
84MP0000358_abnormal_cell_content/1.09617421
85MP0009333_abnormal_splenocyte_physiolog1.09553866
86MP0005409_darkened_coat_color1.08546936
87MP0008789_abnormal_olfactory_epithelium1.08445447
88MP0002722_abnormal_immune_system1.07818492
89MP0002723_abnormal_immune_serum1.07323448
90MP0003567_abnormal_fetal_cardiomyocyte1.06987011
91MP0002088_abnormal_embryonic_growth/wei1.06508978
92MP0000703_abnormal_thymus_morphology1.06100626
93MP0001800_abnormal_humoral_immune1.05822928
94MP0002452_abnormal_antigen_presenting1.05628197
95MP0002405_respiratory_system_inflammati1.04725931
96MP0000350_abnormal_cell_proliferation1.04655461
97MP0002090_abnormal_vision1.01649322
98MP0005379_endocrine/exocrine_gland_phen1.01366943
99MP0002229_neurodegeneration1.01316578
100MP0002751_abnormal_autonomic_nervous1.01262048
101MP0004185_abnormal_adipocyte_glucose1.01167151
102MP0005408_hypopigmentation1.00371589
103MP0002420_abnormal_adaptive_immunity0.99291057
104MP0001819_abnormal_immune_cell0.99161721
105MP0005387_immune_system_phenotype0.98265732
106MP0001790_abnormal_immune_system0.98265732
107MP0005367_renal/urinary_system_phenotyp0.98211037
108MP0000516_abnormal_urinary_system0.98211037
109MP0002161_abnormal_fertility/fecundity0.97550011
110MP0002085_abnormal_embryonic_tissue0.97520987
111MP0004947_skin_inflammation0.97312093
112MP0002877_abnormal_melanocyte_morpholog0.96070426
113MP0002009_preneoplasia0.95912620
114MP0002092_abnormal_eye_morphology0.93606470
115MP0005084_abnormal_gallbladder_morpholo0.93050012
116MP0006072_abnormal_retinal_apoptosis0.92542701
117MP0005220_abnormal_exocrine_pancreas0.91928208
118MP0005395_other_phenotype0.91707731
119MP0005310_abnormal_salivary_gland0.90783503
120MP0002019_abnormal_tumor_incidence0.90399725
121MP0001191_abnormal_skin_condition0.90355320
122MP0010307_abnormal_tumor_latency0.89161592
123MP0003936_abnormal_reproductive_system0.88739058
124MP0010234_abnormal_vibrissa_follicle0.87754566
125MP0003787_abnormal_imprinting0.87548236
126MP0001697_abnormal_embryo_size0.87352044
127MP0009384_cardiac_valve_regurgitation0.86788181
128MP0005499_abnormal_olfactory_system0.86633858
129MP0005394_taste/olfaction_phenotype0.86633858
130MP0000613_abnormal_salivary_gland0.86617100
131MP0003941_abnormal_skin_development0.86503205
132MP0002084_abnormal_developmental_patter0.85775135
133MP0000716_abnormal_immune_system0.84914051
134MP0003448_altered_tumor_morphology0.84065834
135MP0000313_abnormal_cell_death0.83700764
136MP0001672_abnormal_embryogenesis/_devel0.83076676
137MP0005380_embryogenesis_phenotype0.83076676
138MP0002080_prenatal_lethality0.83021780
139MP0003656_abnormal_erythrocyte_physiolo0.82719146
140MP0004381_abnormal_hair_follicle0.81805727
141MP0005464_abnormal_platelet_physiology0.81492169
142MP0009703_decreased_birth_body0.81393946
143MP0002163_abnormal_gland_morphology0.81294618
144MP0002429_abnormal_blood_cell0.81282071
145MP0000627_abnormal_mammary_gland0.79557218
146MP0000747_muscle_weakness0.78512806
147MP0005423_abnormal_somatic_nervous0.77057276
148MP0001486_abnormal_startle_reflex0.76284981
149MP0002396_abnormal_hematopoietic_system0.74894180
150MP0000428_abnormal_craniofacial_morphol0.74054271
151MP0003786_premature_aging0.72872015
152MP0005621_abnormal_cell_physiology0.70870587
153MP0005391_vision/eye_phenotype0.70578976
154MP0004134_abnormal_chest_morphology0.67451994
155MP0003631_nervous_system_phenotype0.65892503
156MP0000377_abnormal_hair_follicle0.65118552
157MP0009672_abnormal_birth_weight0.63680065
158MP0003699_abnormal_female_reproductive0.62074506
159MP0003984_embryonic_growth_retardation0.61565996
160MP0005384_cellular_phenotype0.61498464
161MP0004142_abnormal_muscle_tone0.60153503
162MP0000778_abnormal_nervous_system0.59548363
163MP0000490_abnormal_crypts_of0.58728403
164MP0001963_abnormal_hearing_physiology0.57686580

Predicted human phenotypes

RankGene SetZ-score
1Cerebral hypomyelination (HP:0006808)4.63510918
2Neurofibrillary tangles (HP:0002185)4.42234962
3Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)4.39848813
4Degeneration of the lateral corticospinal tracts (HP:0002314)4.39848813
5Peripheral hypomyelination (HP:0007182)4.09025594
6Segmental peripheral demyelination/remyelination (HP:0003481)3.88318641
7Birth length less than 3rd percentile (HP:0003561)3.74001791
8Breast hypoplasia (HP:0003187)3.63409900
9CNS hypomyelination (HP:0003429)3.60588159
10Parakeratosis (HP:0001036)3.47799268
11Abnormality of T cell number (HP:0011839)3.47356951
12Hypoplastic pelvis (HP:0008839)3.46765040
13Papillary thyroid carcinoma (HP:0002895)3.34477878
14T lymphocytopenia (HP:0005403)3.27219156
15Thyroid carcinoma (HP:0002890)3.24334576
16Split foot (HP:0001839)3.20702092
17B lymphocytopenia (HP:0010976)3.12298261
18Autoimmune hemolytic anemia (HP:0001890)3.08256224
19Abnormality of the corticospinal tract (HP:0002492)3.04403832
20Cerebral inclusion bodies (HP:0100314)3.03599413
21Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.95391582
22Hematochezia (HP:0002573)2.95389977
23Abnormality of B cell number (HP:0010975)2.90584351
24Anteriorly placed anus (HP:0001545)2.83427917
25Severe combined immunodeficiency (HP:0004430)2.78686430
26Morphological abnormality of the inner ear (HP:0011390)2.76843033
27Onion bulb formation (HP:0003383)2.75567548
28Adrenal hypoplasia (HP:0000835)2.75130452
29Thyroiditis (HP:0100646)2.73003975
30Stomatitis (HP:0010280)2.71822318
31Progressive inability to walk (HP:0002505)2.69748248
32Combined immunodeficiency (HP:0005387)2.69544754
33Termporal pattern (HP:0011008)2.69107980
34Insidious onset (HP:0003587)2.69107980
35Medulloblastoma (HP:0002885)2.66508025
36Eosinophilia (HP:0001880)2.66372301
37Duplicated collecting system (HP:0000081)2.65791948
38Increased IgM level (HP:0003496)2.65300943
39Abnormal auditory evoked potentials (HP:0006958)2.64305523
40Oligodactyly (hands) (HP:0001180)2.60485786
41Amyotrophic lateral sclerosis (HP:0007354)2.60430434
42Carpal bone hypoplasia (HP:0001498)2.59195578
43Autoamputation (HP:0001218)2.57206648
44Spastic tetraparesis (HP:0001285)2.56466116
45Small epiphyses (HP:0010585)2.52603608
46Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.52410603
47Pancreatic islet-cell hyperplasia (HP:0004510)2.51201715
48Postnatal microcephaly (HP:0005484)2.47424934
49Short tibia (HP:0005736)2.47162904
50Barrel-shaped chest (HP:0001552)2.46492730
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.44786446
52Abnormality of methionine metabolism (HP:0010901)2.44351044
53Ureteral duplication (HP:0000073)2.43989676
54Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.42911359
55Aplasia involving forearm bones (HP:0009822)2.41740121
56Absent forearm bone (HP:0003953)2.41740121
57Abnormality of eosinophils (HP:0001879)2.41212096
58Chronic hepatic failure (HP:0100626)2.40333885
59Colon cancer (HP:0003003)2.39552101
60Hypoproteinemia (HP:0003075)2.38874444
61Abnormal lung lobation (HP:0002101)2.38837492
62Confusion (HP:0001289)2.38361320
63Irregular epiphyses (HP:0010582)2.33844036
64Impulsivity (HP:0100710)2.31826271
65Intestinal atresia (HP:0011100)2.28813142
66Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27497181
67Premature skin wrinkling (HP:0100678)2.27284185
68Spastic paraparesis (HP:0002313)2.26937060
69Abnormality of the umbilical cord (HP:0010881)2.26097402
70Aqueductal stenosis (HP:0002410)2.25012920
71Stomach cancer (HP:0012126)2.24195889
72Aplasia/Hypoplasia of the uvula (HP:0010293)2.22393443
73Sensory axonal neuropathy (HP:0003390)2.21894429
74Absent radius (HP:0003974)2.21439944
75Intention tremor (HP:0002080)2.19142944
76Abnormality of chromosome stability (HP:0003220)2.18815742
77Cortical dysplasia (HP:0002539)2.18201179
78Gonadotropin excess (HP:0000837)2.15474770
79Embryonal renal neoplasm (HP:0011794)2.15302911
80Spastic gait (HP:0002064)2.14595690
81Abnormality of the renal collecting system (HP:0004742)2.14310790
82Absent septum pellucidum (HP:0001331)2.13692051
83Shoulder girdle muscle weakness (HP:0003547)2.12895368
84Albinism (HP:0001022)2.12775491
85Volvulus (HP:0002580)2.12738157
86Transitional cell carcinoma of the bladder (HP:0006740)2.12020782
87Hypomagnesemia (HP:0002917)2.11676038
88Dyschromatopsia (HP:0007641)2.11620028
89Facial hemangioma (HP:0000329)2.11610440
90Dynein arm defect of respiratory motile cilia (HP:0012255)2.11325809
91Absent/shortened dynein arms (HP:0200106)2.11325809
92Sparse lateral eyebrow (HP:0005338)2.10310023
93Granulocytopenia (HP:0001913)2.09965680
94Abnormal hair whorl (HP:0010721)2.09327732
95Clitoromegaly (HP:0000057)2.08477009
96IgG deficiency (HP:0004315)2.06076895
97Rhabdomyosarcoma (HP:0002859)2.04835331
98Abnormality of the anterior horn cell (HP:0006802)2.04446381
99Degeneration of anterior horn cells (HP:0002398)2.04446381
100Agnosia (HP:0010524)2.04263922
101Rough bone trabeculation (HP:0100670)2.04038068
102Aplasia/Hypoplasia of the tibia (HP:0005772)2.03353699
103Stenosis of the external auditory canal (HP:0000402)2.02234664
104Abnormality of the clitoris (HP:0000056)2.00205077
105Abnormality of T cells (HP:0002843)1.99235278
106Abnormality of cochlea (HP:0000375)1.98677326
107Flat capital femoral epiphysis (HP:0003370)1.97676243
108Abnormality of endocrine pancreas physiology (HP:0012093)1.97564315
109Abnormality of the pancreatic islet cells (HP:0006476)1.97564315
110Absent epiphyses (HP:0010577)1.96802404
111Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.96802404
112Gastrointestinal carcinoma (HP:0002672)1.96264651
113Malignant gastrointestinal tract tumors (HP:0006749)1.96264651
114Bifid tongue (HP:0010297)1.95505064
115Capillary hemangiomas (HP:0005306)1.95498017
116Abnormality of the labia minora (HP:0012880)1.95434359
117Abnormality of the phalanges of the 2nd finger (HP:0009541)1.93407639
118Bladder neoplasm (HP:0009725)1.91454530
119Bladder carcinoma (HP:0002862)1.91454530
120Ovarian neoplasm (HP:0100615)1.90965479
121Biliary tract neoplasm (HP:0100574)1.90824984
122Cutaneous melanoma (HP:0012056)1.90749165
123Nephrogenic diabetes insipidus (HP:0009806)1.90398081
124Meckel diverticulum (HP:0002245)1.90021662
125Aplasia/hypoplasia of the humerus (HP:0006507)1.89976317
126Hypoplasia of the capital femoral epiphysis (HP:0003090)1.89474165
127Synostosis involving the elbow (HP:0003938)1.88967930
128Humeroradial synostosis (HP:0003041)1.88967930
129Abnormality of the septum pellucidum (HP:0007375)1.88465484
130Autoimmune thrombocytopenia (HP:0001973)1.87645494
131Nephroblastoma (Wilms tumor) (HP:0002667)1.87593356
132Delayed epiphyseal ossification (HP:0002663)1.86631198
133Aplasia/hypoplasia of the uterus (HP:0008684)1.85449886
134Abnormal trabecular bone morphology (HP:0100671)1.85125684
135Abnormality of the fetal cardiovascular system (HP:0010948)1.83448579
136Abnormal umbilical cord blood vessels (HP:0011403)1.83448579
137Single umbilical artery (HP:0001195)1.83448579
138Menstrual irregularities (HP:0000858)1.83017142
139Gonadal dysgenesis (HP:0000133)1.82370372
140Short clavicles (HP:0000894)1.82359206
141Paraparesis (HP:0002385)1.82263050
142Congenital ichthyosiform erythroderma (HP:0007431)1.81894093
143Ependymoma (HP:0002888)1.81187106
144Abnormal spermatogenesis (HP:0008669)1.81122829
145Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80084343
146Duodenal stenosis (HP:0100867)1.79614399
147Small intestinal stenosis (HP:0012848)1.79614399
148Abnormality of the ileum (HP:0001549)1.79550123
149Aplasia/Hypoplasia of the clavicles (HP:0006710)1.79053519
150Fatigue (HP:0012378)1.78962663
151Secondary amenorrhea (HP:0000869)1.78630735
152Amaurosis fugax (HP:0100576)1.78588893
153Leiomyosarcoma (HP:0100243)1.78511656
154Uterine leiomyosarcoma (HP:0002891)1.78511656
155Deep philtrum (HP:0002002)1.78247873
156Oligodactyly (HP:0012165)1.77503557
157Congenital primary aphakia (HP:0007707)1.77478678
158Increased circulating renin level (HP:0000848)1.77274110
159Pelvic girdle muscle weakness (HP:0003749)1.76618993
160Male infertility (HP:0003251)1.76138477
161Osteolytic defects of the phalanges of the hand (HP:0009771)1.75975383
162Osteolytic defects of the hand bones (HP:0009699)1.75975383
163Clumsiness (HP:0002312)1.75776400
164Retinal dysplasia (HP:0007973)1.74997631
165Neoplasm of the small intestine (HP:0100833)1.73904422
166Supernumerary spleens (HP:0009799)1.73819477
167Curly hair (HP:0002212)1.73706915
168Abnormality of the musculature of the pelvis (HP:0001469)1.73218834
169Abnormality of the hip-girdle musculature (HP:0001445)1.73218834
170Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73168022
171Abnormal protein N-linked glycosylation (HP:0012347)1.73168022
172Abnormal protein glycosylation (HP:0012346)1.73168022
173Abnormal glycosylation (HP:0012345)1.73168022
174Panhypogammaglobulinemia (HP:0003139)1.73152349
175Hepatosplenomegaly (HP:0001433)1.73112653
176Breast carcinoma (HP:0003002)1.71988582
177Broad foot (HP:0001769)1.71585521
178Leukocytosis (HP:0001974)1.70383861
179Short humerus (HP:0005792)1.70272334
180Dysmetria (HP:0001310)1.69836280
181Brittle hair (HP:0002299)1.69373849
182Neoplasm of the oral cavity (HP:0100649)1.69269360
183Median cleft lip (HP:0000161)1.69107028
184Progressive neurologic deterioration (HP:0002344)1.67903643
185Slow saccadic eye movements (HP:0000514)1.66050041
186Increased serum pyruvate (HP:0003542)1.64510503
187Abnormality of glycolysis (HP:0004366)1.64510503
188Overlapping toe (HP:0001845)1.64168944
189Prolonged neonatal jaundice (HP:0006579)1.62583633

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK395.14064729
2TRIM283.64460223
3BUB13.62437923
4MAP4K23.16733612
5OXSR13.14309910
6SIK32.96748866
7EPHB12.66962027
8WEE12.66000551
9TESK22.50885389
10ERBB32.44555620
11MST42.26081515
12LATS12.05166434
13EIF2AK31.98386674
14MKNK11.94653716
15BRSK21.91636198
16PNCK1.89756916
17MAPKAPK51.89481376
18ACVR1B1.87232920
19BCR1.80617242
20NEK21.80196155
21EPHA31.76247479
22MKNK21.74631311
23IRAK11.69989287
24TNIK1.62598752
25WNK41.62543134
26MET1.62139149
27CSNK1G31.60668065
28CSNK1G11.58806984
29CSNK1A1L1.58489182
30PLK41.56623977
31TXK1.50838215
32STK31.47737457
33CDC71.42582844
34MAP3K141.38900630
35AKT31.32327079
36FER1.28882908
37YES11.25892189
38PBK1.24867650
39STK161.23828225
40EPHA21.22360687
41DYRK31.20194052
42WNK31.19583864
43NEK11.19556901
44CLK11.19430944
45RPS6KA51.16336142
46CSNK1G21.15253986
47IKBKE1.13473650
48MELK1.12386372
49BMPR1B1.12321495
50NEK61.11614843
51DYRK21.11465468
52EIF2AK21.10439352
53TTK1.10380557
54CAMKK21.08955824
55TEC1.08157936
56CHEK21.07958261
57STK101.07898034
58ZAK1.04035948
59PKN11.03785961
60BCKDK1.02248089
61SRPK11.00532743
62KSR10.98921419
63CAMK1D0.95850028
64TGFBR10.95800171
65FGFR30.94117233
66WNK10.93476606
67CDK60.92914924
68TAF10.91878673
69FGR0.91316230
70EIF2AK10.91176655
71IRAK20.90051407
72PIM20.88580637
73PLK20.87227558
74TGFBR20.85397490
75MAP3K50.84469952
76PLK10.83795856
77PLK30.82927733
78TSSK60.82703584
79NEK90.80213858
80CHEK10.79061928
81MAP3K80.78781579
82NUAK10.78634152
83PIM10.76445589
84VRK10.76293089
85IRAK40.75262130
86CDK190.74488281
87FGFR20.73991116
88FRK0.73884158
89CAMK1G0.73045134
90MATK0.71870128
91BRD40.70394086
92MAP3K40.64687800
93ICK0.63531159
94CAMK2B0.62864306
95MAP2K20.62774395
96BRSK10.61810087
97ERBB40.61329641
98CDK70.59895365
99KSR20.59876033
100PDK20.59798668
101MARK30.58893150
102JAK10.56283213
103JAK30.55755637
104NLK0.55132713
105MUSK0.54363323
106BRAF0.54239411
107NTRK10.53950556
108PAK60.53148501
109IKBKB0.52792397
110AURKA0.52626071
111ADRBK20.52284095
112AURKB0.51637013
113BMPR20.51630466
114FLT30.49121843
115PRKD30.47411638
116PAK10.46903754
117ATR0.45624827
118ATM0.45578916
119CSNK1D0.45412031
120ITK0.44939153
121CDK120.44487395
122GSK3A0.44405584
123CSNK1A10.44167459
124CDK10.43936964
125TIE10.43739258
126LIMK10.43510272
127PASK0.42337970
128STK38L0.42306615
129FES0.41828755
130MARK20.41497641
131MAPK100.41187355
132CDK20.40939912
133CDK30.40015712
134GRK70.39991400
135JAK20.39205300
136RPS6KA40.39170510
137PDGFRB0.38649904
138ALK0.37355258
139ROCK20.37160129
140MAPK150.36552914
141CCNB10.35240814
142SCYL20.34863771
143PRKCE0.34457117
144RAF10.34399270
145PDPK10.33962657
146ABL10.33268600
147EGFR0.31981047
148SGK4940.31940007
149SGK2230.31940007
150PRKCI0.31174808
151CSNK1E0.31092778
152TYK20.29394913

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.75468306
2Vitamin B6 metabolism_Homo sapiens_hsa007504.67783395
3Steroid biosynthesis_Homo sapiens_hsa001004.20545436
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.02564123
5RNA polymerase_Homo sapiens_hsa030202.94930436
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80213272
7Ether lipid metabolism_Homo sapiens_hsa005652.66185249
8Protein export_Homo sapiens_hsa030602.52422544
9Fatty acid elongation_Homo sapiens_hsa000622.47574128
10Basal transcription factors_Homo sapiens_hsa030222.34956689
11Folate biosynthesis_Homo sapiens_hsa007902.15967549
12RNA transport_Homo sapiens_hsa030131.97712863
13Cell cycle_Homo sapiens_hsa041101.96860390
14Sphingolipid metabolism_Homo sapiens_hsa006001.96012587
15Measles_Homo sapiens_hsa051621.79363324
16Legionellosis_Homo sapiens_hsa051341.72793447
17Propanoate metabolism_Homo sapiens_hsa006401.71378493
18Glycerophospholipid metabolism_Homo sapiens_hsa005641.69745431
19Regulation of autophagy_Homo sapiens_hsa041401.69350483
20Sulfur metabolism_Homo sapiens_hsa009201.68581427
21DNA replication_Homo sapiens_hsa030301.60571627
22Non-homologous end-joining_Homo sapiens_hsa034501.56876508
23Spliceosome_Homo sapiens_hsa030401.55528528
24Linoleic acid metabolism_Homo sapiens_hsa005911.55090127
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.50462429
26Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.42295288
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41810662
28Homologous recombination_Homo sapiens_hsa034401.41421235
29Mismatch repair_Homo sapiens_hsa034301.39474205
30Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.35456414
31Fanconi anemia pathway_Homo sapiens_hsa034601.34073559
32RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.30718005
33Hepatitis B_Homo sapiens_hsa051611.29520855
34Vitamin digestion and absorption_Homo sapiens_hsa049771.27245319
35p53 signaling pathway_Homo sapiens_hsa041151.25885470
36Nucleotide excision repair_Homo sapiens_hsa034201.19479343
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.17693521
38Pyrimidine metabolism_Homo sapiens_hsa002401.10460651
39Jak-STAT signaling pathway_Homo sapiens_hsa046301.07829789
40Colorectal cancer_Homo sapiens_hsa052101.05834859
41N-Glycan biosynthesis_Homo sapiens_hsa005101.05092686
42mRNA surveillance pathway_Homo sapiens_hsa030151.00502217
43Influenza A_Homo sapiens_hsa051640.97869597
44Oocyte meiosis_Homo sapiens_hsa041140.95374333
45Maturity onset diabetes of the young_Homo sapiens_hsa049500.94704459
46Renal cell carcinoma_Homo sapiens_hsa052110.92911047
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.92234611
48RNA degradation_Homo sapiens_hsa030180.91532744
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.91369618
50Apoptosis_Homo sapiens_hsa042100.91117793
51TNF signaling pathway_Homo sapiens_hsa046680.91016825
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.88110215
53Purine metabolism_Homo sapiens_hsa002300.88052850
54Lysosome_Homo sapiens_hsa041420.87367309
55Arginine and proline metabolism_Homo sapiens_hsa003300.86894329
56Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.86125299
57Toll-like receptor signaling pathway_Homo sapiens_hsa046200.85388560
58Thyroid cancer_Homo sapiens_hsa052160.82253928
59Pancreatic cancer_Homo sapiens_hsa052120.80605294
60Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78405703
61Arachidonic acid metabolism_Homo sapiens_hsa005900.77211980
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77138546
63Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75978981
64Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.73709193
65Pancreatic secretion_Homo sapiens_hsa049720.72907512
66Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.72215787
67Endocytosis_Homo sapiens_hsa041440.71393859
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70212915
69Hematopoietic cell lineage_Homo sapiens_hsa046400.69696806
70Dorso-ventral axis formation_Homo sapiens_hsa043200.69018369
71Mineral absorption_Homo sapiens_hsa049780.68880794
72Fatty acid metabolism_Homo sapiens_hsa012120.68722172
73Glutathione metabolism_Homo sapiens_hsa004800.66930647
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.65894536
75Small cell lung cancer_Homo sapiens_hsa052220.65494475
76Histidine metabolism_Homo sapiens_hsa003400.64447844
77Rheumatoid arthritis_Homo sapiens_hsa053230.64186140
78Inositol phosphate metabolism_Homo sapiens_hsa005620.64113934
79Glycerolipid metabolism_Homo sapiens_hsa005610.62552556
80Proteasome_Homo sapiens_hsa030500.60617553
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.60360309
82Hepatitis C_Homo sapiens_hsa051600.58998966
83Systemic lupus erythematosus_Homo sapiens_hsa053220.56780134
84Other glycan degradation_Homo sapiens_hsa005110.55784024
85Non-small cell lung cancer_Homo sapiens_hsa052230.55517795
86Prolactin signaling pathway_Homo sapiens_hsa049170.54907258
87Osteoclast differentiation_Homo sapiens_hsa043800.54065359
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53947535
89Pentose phosphate pathway_Homo sapiens_hsa000300.53536052
90mTOR signaling pathway_Homo sapiens_hsa041500.53510502
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53106751
92Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52749613
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.52462117
94Allograft rejection_Homo sapiens_hsa053300.51734220
95Hedgehog signaling pathway_Homo sapiens_hsa043400.51720096
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.51619492
97Tight junction_Homo sapiens_hsa045300.50967439
98HTLV-I infection_Homo sapiens_hsa051660.50207733
99Epstein-Barr virus infection_Homo sapiens_hsa051690.49581330
100Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48786673
101Fatty acid biosynthesis_Homo sapiens_hsa000610.48613142
102Prostate cancer_Homo sapiens_hsa052150.48306251
103Chronic myeloid leukemia_Homo sapiens_hsa052200.47934937
104Choline metabolism in cancer_Homo sapiens_hsa052310.47907565
105Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.47523701
106Endometrial cancer_Homo sapiens_hsa052130.47386172
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.47045963
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.45995577
109Viral carcinogenesis_Homo sapiens_hsa052030.45782287
110FoxO signaling pathway_Homo sapiens_hsa040680.44862225
111Acute myeloid leukemia_Homo sapiens_hsa052210.44739291
112Sulfur relay system_Homo sapiens_hsa041220.44734954
113Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44409895
114Graft-versus-host disease_Homo sapiens_hsa053320.43447778
115Toxoplasmosis_Homo sapiens_hsa051450.42863462
116Autoimmune thyroid disease_Homo sapiens_hsa053200.42127440
117NOD-like receptor signaling pathway_Homo sapiens_hsa046210.40621692
118Metabolic pathways_Homo sapiens_hsa011000.40376919
119African trypanosomiasis_Homo sapiens_hsa051430.39831000
120Type I diabetes mellitus_Homo sapiens_hsa049400.39676049
121TGF-beta signaling pathway_Homo sapiens_hsa043500.39324914
122Salmonella infection_Homo sapiens_hsa051320.38743026
123Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37492337
124Base excision repair_Homo sapiens_hsa034100.36527554
125Renin-angiotensin system_Homo sapiens_hsa046140.33468411
126Ovarian steroidogenesis_Homo sapiens_hsa049130.32164548
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31026933
128MicroRNAs in cancer_Homo sapiens_hsa052060.29237353
129Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.28752530
130Phospholipase D signaling pathway_Homo sapiens_hsa040720.24307606
131T cell receptor signaling pathway_Homo sapiens_hsa046600.24023331
132Herpes simplex infection_Homo sapiens_hsa051680.23768520
133Asthma_Homo sapiens_hsa053100.23088516
134Selenocompound metabolism_Homo sapiens_hsa004500.21613597
135Protein digestion and absorption_Homo sapiens_hsa049740.21367876
136Circadian rhythm_Homo sapiens_hsa047100.21112178
137Hippo signaling pathway_Homo sapiens_hsa043900.21068312
138Alcoholism_Homo sapiens_hsa050340.19885375
139Antigen processing and presentation_Homo sapiens_hsa046120.19804910
140Shigellosis_Homo sapiens_hsa051310.19631203
141Malaria_Homo sapiens_hsa051440.18748936
142Ras signaling pathway_Homo sapiens_hsa040140.18375095
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.17172192
144One carbon pool by folate_Homo sapiens_hsa006700.16994558
145Axon guidance_Homo sapiens_hsa043600.16621173
146Primary immunodeficiency_Homo sapiens_hsa053400.16158933
147NF-kappa B signaling pathway_Homo sapiens_hsa040640.16023717

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