MFSD1P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mast cell activation involved in immune response (GO:0002279)4.33378017
2mast cell degranulation (GO:0043303)4.33378017
3mast cell activation (GO:0045576)4.33121560
4protein K63-linked deubiquitination (GO:0070536)4.19239996
5negative regulation of mast cell activation (GO:0033004)3.97219177
6neutrophil activation involved in immune response (GO:0002283)3.96580222
7protein K11-linked deubiquitination (GO:0035871)3.77228994
8negative regulation of thymocyte apoptotic process (GO:0070244)3.61286373
9immunoglobulin mediated immune response (GO:0016064)3.59176332
10protein K48-linked deubiquitination (GO:0071108)3.53326944
11lysosome localization (GO:0032418)3.50828823
12centriole replication (GO:0007099)3.49311003
13purine deoxyribonucleotide catabolic process (GO:0009155)3.47561005
14B cell mediated immunity (GO:0019724)3.46536311
15positive regulation of granulocyte differentiation (GO:0030854)3.45986051
16phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.37383827
17negative regulation of calcium ion-dependent exocytosis (GO:0045955)3.35269887
18histone mRNA catabolic process (GO:0071044)3.33070639
19regulation of establishment of cell polarity (GO:2000114)3.28287959
20L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.26411877
21hepatocyte apoptotic process (GO:0097284)3.23416355
22regulation of glucokinase activity (GO:0033131)3.22164818
23regulation of hexokinase activity (GO:1903299)3.22164818
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.21502355
25rRNA modification (GO:0000154)3.19983564
26G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.19298675
27rRNA methylation (GO:0031167)3.18145341
28purinergic nucleotide receptor signaling pathway (GO:0035590)3.16036685
29interferon-gamma-mediated signaling pathway (GO:0060333)3.15216034
30hepatocyte differentiation (GO:0070365)3.13209887
31regulation of B cell receptor signaling pathway (GO:0050855)3.11522054
32positive regulation of chemokine secretion (GO:0090197)3.11481767
33adenosine metabolic process (GO:0046085)3.07203287
34negative regulation of heart rate (GO:0010459)3.06323150
35tryptophan metabolic process (GO:0006568)3.01495525
36negative regulation of calcium ion transport into cytosol (GO:0010523)2.97825132
37leukotriene biosynthetic process (GO:0019370)2.95455545
38negative regulation of neurotransmitter secretion (GO:0046929)2.90164985
39regulation of chemokine secretion (GO:0090196)2.88420088
40leukocyte degranulation (GO:0043299)2.87595137
41regulation of mast cell activation (GO:0033003)2.87116877
42negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.80977867
43regulation of pigment cell differentiation (GO:0050932)2.80095597
44neural tube formation (GO:0001841)2.79620410
45monoubiquitinated protein deubiquitination (GO:0035520)2.78005584
46negative regulation of neurotransmitter transport (GO:0051589)2.77892075
47platelet dense granule organization (GO:0060155)2.76505495
48neutrophil activation (GO:0042119)2.76399192
49positive regulation of vasculogenesis (GO:2001214)2.76106232
50base-excision repair, AP site formation (GO:0006285)2.74785699
51cullin deneddylation (GO:0010388)2.74560959
52positive regulation of antigen processing and presentation (GO:0002579)2.74219203
53definitive hemopoiesis (GO:0060216)2.72174679
54tyrosine phosphorylation of STAT protein (GO:0007260)2.70707470
55negative regulation of T cell apoptotic process (GO:0070233)2.70151200
56myeloid cell activation involved in immune response (GO:0002275)2.68360446
57positive regulation of type 2 immune response (GO:0002830)2.66679712
58energy homeostasis (GO:0097009)2.66589152
59B cell receptor signaling pathway (GO:0050853)2.65086940
60positive regulation of developmental pigmentation (GO:0048087)2.64775760
61positive regulation of mast cell activation (GO:0033005)2.64463296
62interkinetic nuclear migration (GO:0022027)2.63844037
63prenylation (GO:0097354)2.61213454
64protein prenylation (GO:0018342)2.61213454
65histone H3-K4 trimethylation (GO:0080182)2.58937354
66protein deneddylation (GO:0000338)2.58281135
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.58010979
68positive regulation of interleukin-17 production (GO:0032740)2.57582321
69antigen receptor-mediated signaling pathway (GO:0050851)2.57574596
70nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.57429456
71nerve growth factor signaling pathway (GO:0038180)2.57055477
72positive regulation of interleukin-1 beta secretion (GO:0050718)2.56940339
73regulation of establishment or maintenance of cell polarity (GO:0032878)2.56823792
74response to X-ray (GO:0010165)2.56712930
75antigen processing and presentation via MHC class Ib (GO:0002475)2.56089854
76positive regulation of alpha-beta T cell proliferation (GO:0046641)2.54935803
77serotonin receptor signaling pathway (GO:0007210)2.54856896
78exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.54738708
79positive regulation of mast cell degranulation (GO:0043306)2.53221830
80positive regulation of mast cell activation involved in immune response (GO:0033008)2.53221830
81methionine biosynthetic process (GO:0009086)2.53210076
82T cell costimulation (GO:0031295)2.52707352
83mature B cell differentiation (GO:0002335)2.52027100
84regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.49905865
85positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.49905865
86amino acid salvage (GO:0043102)2.49884651
87L-methionine salvage (GO:0071267)2.49884651
88L-methionine biosynthetic process (GO:0071265)2.49884651
89positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.49764920
90regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.49764920
91positive regulation of interleukin-1 beta production (GO:0032731)2.49545297
92cytoplasmic mRNA processing body assembly (GO:0033962)2.49281644
93negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.49113293
94lymphocyte costimulation (GO:0031294)2.49000601
95deoxyribose phosphate catabolic process (GO:0046386)2.47622545
96indolalkylamine metabolic process (GO:0006586)2.47431312
97positive regulation of circadian rhythm (GO:0042753)2.47208319
98deoxyribonucleotide catabolic process (GO:0009264)2.46736277
99histone mRNA metabolic process (GO:0008334)2.45953547
100activated T cell proliferation (GO:0050798)2.43629262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.07941025
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.42850689
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.03772850
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.67884390
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.63786147
6TAF15_26573619_Chip-Seq_HEK293_Human2.51159550
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.37697816
8CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33065437
9IGF1R_20145208_ChIP-Seq_DFB_Human2.31076154
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.30522026
11IRF8_21731497_ChIP-ChIP_J774_Mouse2.16465390
12VDR_22108803_ChIP-Seq_LS180_Human2.10302987
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.09411303
14ZNF274_21170338_ChIP-Seq_K562_Hela2.02722317
15EWS_26573619_Chip-Seq_HEK293_Human2.01018066
16SCL_19346495_ChIP-Seq_HPC-7_Human1.99914777
17RUNX_20019798_ChIP-Seq_JUKART_Human1.89535982
18VDR_23849224_ChIP-Seq_CD4+_Human1.88399813
19GBX2_23144817_ChIP-Seq_PC3_Human1.84882415
20CIITA_25753668_ChIP-Seq_RAJI_Human1.83948946
21ELK1_19687146_ChIP-ChIP_HELA_Human1.78358130
22FUS_26573619_Chip-Seq_HEK293_Human1.76241453
23MYB_26560356_Chip-Seq_TH2_Human1.76098620
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.75352801
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73554405
26RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70472452
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67453557
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.66337251
29ER_23166858_ChIP-Seq_MCF-7_Human1.63545785
30PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61634035
31E2F4_17652178_ChIP-ChIP_JURKAT_Human1.60068928
32GATA3_26560356_Chip-Seq_TH2_Human1.56716287
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.56447018
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56395255
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.55000792
36SALL1_21062744_ChIP-ChIP_HESCs_Human1.54026933
37IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.52105611
38CBP_20019798_ChIP-Seq_JUKART_Human1.52105611
39GABP_17652178_ChIP-ChIP_JURKAT_Human1.51840443
40ELF1_17652178_ChIP-ChIP_JURKAT_Human1.49422165
41IRF1_19129219_ChIP-ChIP_H3396_Human1.48861035
42RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48024312
43PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47928202
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42699492
45P300_19829295_ChIP-Seq_ESCs_Human1.41246308
46EZH2_27294783_Chip-Seq_NPCs_Mouse1.39769887
47GATA3_27048872_Chip-Seq_THYMUS_Human1.35692103
48FOXP3_21729870_ChIP-Seq_TREG_Human1.34027995
49FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32146625
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30933237
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30885271
52EGR1_23403033_ChIP-Seq_LIVER_Mouse1.29681330
53MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.28513935
54CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.27676344
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.27582907
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27195180
57KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26489956
58SMAD_19615063_ChIP-ChIP_OVARY_Human1.25146909
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24229196
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.24195967
61BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.22859282
62SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22392279
63SALL4_22934838_ChIP-ChIP_CD34+_Human1.22311903
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.22180053
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.20898101
66FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20242129
67PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19613261
68SPI1_23547873_ChIP-Seq_NB4_Human1.19608590
69EST1_17652178_ChIP-ChIP_JURKAT_Human1.19046893
70STAT3_23295773_ChIP-Seq_U87_Human1.18968849
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.17508201
72HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.17086352
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.16325195
74NFE2_27457419_Chip-Seq_LIVER_Mouse1.16015114
75SMAD4_21799915_ChIP-Seq_A2780_Human1.14761356
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.14005276
77STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10720231
78SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.09011164
79NANOG_19829295_ChIP-Seq_ESCs_Human1.08073349
80SOX2_19829295_ChIP-Seq_ESCs_Human1.08073349
81PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07775350
82FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.07672532
83MYB_26560356_Chip-Seq_TH1_Human1.07557861
84MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.07352701
85OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07235989
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06623837
87SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06437192
88CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.06372619
89AR_25329375_ChIP-Seq_VCAP_Human1.06265454
90VDR_24787735_ChIP-Seq_THP-1_Human1.05542403
91HOXB4_20404135_ChIP-ChIP_EML_Mouse1.05532292
92NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05434228
93NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05434228
94FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02760168
95GATA3_26560356_Chip-Seq_TH1_Human1.01715108
96TCF4_23295773_ChIP-Seq_U87_Human0.99599670
97AR_21572438_ChIP-Seq_LNCaP_Human0.98415691
98TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98272344
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.98024982
100AR_20517297_ChIP-Seq_VCAP_Human0.97921933

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002166_altered_tumor_susceptibility3.89334361
2MP0003724_increased_susceptibility_to3.81633201
3MP0001835_abnormal_antigen_presentation3.81148291
4MP0002006_tumorigenesis3.23776933
5MP0002009_preneoplasia3.05648656
6MP0000569_abnormal_digit_pigmentation3.03646821
7MP0008057_abnormal_DNA_replication2.81187415
8MP0005464_abnormal_platelet_physiology2.71573484
9MP0003763_abnormal_thymus_physiology2.33344560
10MP0005671_abnormal_response_to2.19342325
11MP0002148_abnormal_hypersensitivity_rea2.15679387
12MP0003183_abnormal_peptide_metabolism2.15368810
13MP0009697_abnormal_copulation2.15072052
14MP0002396_abnormal_hematopoietic_system2.12859019
15MP0008058_abnormal_DNA_repair2.11780732
16MP0001800_abnormal_humoral_immune2.10355230
17MP0005075_abnormal_melanosome_morpholog2.06617025
18MP0005397_hematopoietic_system_phenotyp1.92486449
19MP0001545_abnormal_hematopoietic_system1.92486449
20MP0009764_decreased_sensitivity_to1.91924175
21MP0005000_abnormal_immune_tolerance1.87939017
22MP0008961_abnormal_basal_metabolism1.83922198
23MP0010094_abnormal_chromosome_stability1.77733629
24MP0002452_abnormal_antigen_presenting1.72035424
25MP0002723_abnormal_immune_serum1.70942484
26MP0001853_heart_inflammation1.68998373
27MP0002420_abnormal_adaptive_immunity1.66132489
28MP0001819_abnormal_immune_cell1.65257386
29MP0006072_abnormal_retinal_apoptosis1.58012516
30MP0000689_abnormal_spleen_morphology1.54656448
31MP0002398_abnormal_bone_marrow1.54400021
32MP0009785_altered_susceptibility_to1.50557415
33MP0000716_abnormal_immune_system1.41578260
34MP0003195_calcinosis1.40028649
35MP0004084_abnormal_cardiac_muscle1.37126718
36MP0005387_immune_system_phenotype1.32530935
37MP0001790_abnormal_immune_system1.32530935
38MP0003646_muscle_fatigue1.30768111
39MP0000516_abnormal_urinary_system1.26582108
40MP0005367_renal/urinary_system_phenotyp1.26582108
41MP0010155_abnormal_intestine_physiology1.24044801
42MP0002722_abnormal_immune_system1.22196914
43MP0000858_altered_metastatic_potential1.22101642
44MP0000685_abnormal_immune_system1.21167598
45MP0008875_abnormal_xenobiotic_pharmacok1.20216303
46MP0000015_abnormal_ear_pigmentation1.19792892
47MP0002405_respiratory_system_inflammati1.19479698
48MP0002429_abnormal_blood_cell1.17237875
49MP0002019_abnormal_tumor_incidence1.16847921
50MP0004215_abnormal_myocardial_fiber1.16431496
51MP0002419_abnormal_innate_immunity1.15479921
52MP0004808_abnormal_hematopoietic_stem1.15245879
53MP0002095_abnormal_skin_pigmentation1.12945142
54MP0004145_abnormal_muscle_electrophysio1.12779020
55MP0008872_abnormal_physiological_respon1.08742891
56MP0002332_abnormal_exercise_endurance1.07425127
57MP0003866_abnormal_defecation1.07311693
58MP0003436_decreased_susceptibility_to1.05409123
59MP0008995_early_reproductive_senescence1.05160441
60MP0004142_abnormal_muscle_tone1.04971847
61MP0000703_abnormal_thymus_morphology1.03616019
62MP0001845_abnormal_inflammatory_respons1.01202914
63MP0004036_abnormal_muscle_relaxation0.97481465
64MP0008775_abnormal_heart_ventricle0.95524952
65MP0005025_abnormal_response_to0.94280780
66MP0002837_dystrophic_cardiac_calcinosis0.93679820
67MP0004484_altered_response_of0.92630051
68MP0003221_abnormal_cardiomyocyte_apopto0.91195911
69MP0003806_abnormal_nucleotide_metabolis0.83797179
70MP0000230_abnormal_systemic_arterial0.83399558
71MP0004043_abnormal_pH_regulation0.81388765
72MP0000249_abnormal_blood_vessel0.80400430
73MP0006036_abnormal_mitochondrial_physio0.79335331
74MP0000465_gastrointestinal_hemorrhage0.79313117
75MP0009763_increased_sensitivity_to0.79233181
76MP0005165_increased_susceptibility_to0.78756300
77MP0001191_abnormal_skin_condition0.78751364
78MP0009333_abnormal_splenocyte_physiolog0.76166664
79MP0005266_abnormal_metabolism0.75934007
80MP0001986_abnormal_taste_sensitivity0.73167526
81MP0003786_premature_aging0.72952744
82MP0005084_abnormal_gallbladder_morpholo0.72775130
83MP0005174_abnormal_tail_pigmentation0.72373599
84MP0003828_pulmonary_edema0.72028337
85MP0001873_stomach_inflammation0.71931379
86MP0005253_abnormal_eye_physiology0.70706849
87MP0006035_abnormal_mitochondrial_morpho0.69217989
88MP0009765_abnormal_xenobiotic_induced0.69005756
89MP0002102_abnormal_ear_morphology0.68221620
90MP0005551_abnormal_eye_electrophysiolog0.66900286
91MP0001756_abnormal_urination0.66024758
92MP0005670_abnormal_white_adipose0.65605284
93MP0008877_abnormal_DNA_methylation0.65598926
94MP0003075_altered_response_to0.64807076
95MP0001666_abnormal_nutrient_absorption0.62203068
96MP0001919_abnormal_reproductive_system0.61819636
97MP0000372_irregular_coat_pigmentation0.59965945
98MP0006292_abnormal_olfactory_placode0.59507677
99MP0004147_increased_porphyrin_level0.59346215
100MP0006054_spinal_hemorrhage0.58620722

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.58219646
2Abnormality of alanine metabolism (HP:0010916)3.58219646
3Hyperalaninemia (HP:0003348)3.58219646
4Abnormality of the prostate (HP:0008775)3.30205149
5Volvulus (HP:0002580)3.11724973
6Abnormality of midbrain morphology (HP:0002418)3.04622060
7Molar tooth sign on MRI (HP:0002419)3.04622060
8Nemaline bodies (HP:0003798)2.92504148
9Clubbing of toes (HP:0100760)2.87349511
10Abolished electroretinogram (ERG) (HP:0000550)2.84900485
11Abnormality of the left ventricular outflow tract (HP:0011103)2.83915528
12Subaortic stenosis (HP:0001682)2.83915528
13Abnormality of the renal cortex (HP:0011035)2.81513006
14Elevated erythrocyte sedimentation rate (HP:0003565)2.79234404
15Hypoproteinemia (HP:0003075)2.68825849
16IgM deficiency (HP:0002850)2.67655982
17Tubulointerstitial nephritis (HP:0001970)2.58670280
18Type 2 muscle fiber atrophy (HP:0003554)2.52826459
19Stomatitis (HP:0010280)2.52691604
20IgG deficiency (HP:0004315)2.47618986
21Acute myeloid leukemia (HP:0004808)2.46671916
22Abnormality of the renal medulla (HP:0100957)2.46138868
23Decreased electroretinogram (ERG) amplitude (HP:0000654)2.45616732
24Aplastic anemia (HP:0001915)2.45209799
25Renal cortical cysts (HP:0000803)2.43699950
26Neoplasm of the tracheobronchial system (HP:0100552)2.42381425
27Dyschromatopsia (HP:0007641)2.36905335
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.34959273
29Alveolar cell carcinoma (HP:0006519)2.34683218
30Acute hepatic failure (HP:0006554)2.34452611
31Facial diplegia (HP:0001349)2.32436746
32Abnormality of chromosome stability (HP:0003220)2.32054142
33Aplasia/Hypoplasia of the uvula (HP:0010293)2.29811934
34T lymphocytopenia (HP:0005403)2.29175587
35Stomach cancer (HP:0012126)2.26120415
36Panhypogammaglobulinemia (HP:0003139)2.25123967
37Epistaxis (HP:0000421)2.23541334
38Chest pain (HP:0100749)2.23135006
39Abnormality of B cell number (HP:0010975)2.23011829
40Pulmonary fibrosis (HP:0002206)2.21812201
41Agammaglobulinemia (HP:0004432)2.20804637
42Fair hair (HP:0002286)2.19267547
43Muscle fiber inclusion bodies (HP:0100299)2.18979098
44Amaurosis fugax (HP:0100576)2.16582774
45Myelodysplasia (HP:0002863)2.15898133
46Hip dysplasia (HP:0001385)2.15713155
47Pancreatic cysts (HP:0001737)2.15348809
48Acute lymphatic leukemia (HP:0006721)2.13642920
49Thyroiditis (HP:0100646)2.13475283
50Ureteral obstruction (HP:0006000)2.12209522
51Opisthotonus (HP:0002179)2.11856583
52Exertional dyspnea (HP:0002875)2.11616245
53Aplasia/Hypoplasia of the tibia (HP:0005772)2.10744392
54Prolonged bleeding time (HP:0003010)2.10334854
55Abnormality of T cell number (HP:0011839)2.09298990
56Ureteral stenosis (HP:0000071)2.03924345
57Prostate neoplasm (HP:0100787)2.00659455
58Dyskinesia (HP:0100660)2.00600921
59Gaze-evoked nystagmus (HP:0000640)1.98966641
60B lymphocytopenia (HP:0010976)1.97682501
61Neonatal respiratory distress (HP:0002643)1.96050331
62Adactyly (HP:0009776)1.95887558
63Central scotoma (HP:0000603)1.95239892
64Meckel diverticulum (HP:0002245)1.93481338
65Nephronophthisis (HP:0000090)1.92720971
66Abnormality of the preputium (HP:0100587)1.92388391
67Abnormality of the ileum (HP:0001549)1.92342628
68Eosinophilia (HP:0001880)1.91844416
69Thyroid-stimulating hormone excess (HP:0002925)1.89554912
70True hermaphroditism (HP:0010459)1.84657327
71Tubulointerstitial abnormality (HP:0001969)1.82316558
72Severe combined immunodeficiency (HP:0004430)1.82063845
73Tinnitus (HP:0000360)1.79937125
74Pulmonary infiltrates (HP:0002113)1.79738042
75Medulloblastoma (HP:0002885)1.78652070
76Arterial thrombosis (HP:0004420)1.78491981
77Colon cancer (HP:0003003)1.78474555
78Acanthocytosis (HP:0001927)1.78087271
79Nephrogenic diabetes insipidus (HP:0009806)1.78006938
80Congenital stationary night blindness (HP:0007642)1.77629963
81Pancreatic fibrosis (HP:0100732)1.77610005
82Abnormality of eosinophils (HP:0001879)1.77482946
83Abnormality of male internal genitalia (HP:0000022)1.75256280
84Encephalitis (HP:0002383)1.75213603
85Verrucae (HP:0200043)1.72345266
86Papilloma (HP:0012740)1.72345266
87Mediastinal lymphadenopathy (HP:0100721)1.72207044
88Long clavicles (HP:0000890)1.71498419
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70908903
90Muscle fiber atrophy (HP:0100295)1.70512385
91Papilledema (HP:0001085)1.70256270
92Prominent nose (HP:0000448)1.70216366
93Choroideremia (HP:0001139)1.69400128
94Meningitis (HP:0001287)1.67758083
95Abnormality of lateral ventricle (HP:0030047)1.67427477
96Hypoplastic iliac wings (HP:0002866)1.66797335
97Fatigue (HP:0012378)1.66207685
98Progressive inability to walk (HP:0002505)1.66103286
99Genetic anticipation (HP:0003743)1.66102649
100Hypokalemic alkalosis (HP:0001949)1.65783410

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.59704786
2TAOK34.18028844
3NUAK14.16795182
4CDK193.00078143
5BMPR22.86473703
6MAP3K122.84646267
7PIK3CG2.17797909
8TLK12.17626827
9MST42.01885345
10KIT2.00642832
11OBSCN1.99279776
12TEC1.95563864
13ZAK1.86372154
14TXK1.86164792
15FLT31.85701044
16LATS11.76854269
17ERBB31.65539917
18TRPM71.60176330
19WNK31.56059756
20MKNK11.48278417
21BMPR1B1.39585008
22BTK1.22992541
23IKBKE1.22749524
24CDK31.20709577
25IKBKB1.19077152
26SRPK11.16310633
27GRK61.14220427
28SYK1.13284321
29ACVR1B1.13158216
30PLK41.12976640
31MYLK1.12893376
32MKNK21.12618862
33MUSK1.09989392
34JAK11.09178512
35MAP4K11.07657332
36MAP3K61.04234755
37PIK3CA1.01286535
38SIK30.98656807
39NLK0.97948576
40MAP4K20.97671939
41CSF1R0.96240567
42OXSR10.94208941
43PIM10.90824648
44CDK80.90421885
45ITK0.83776166
46MAPK130.81683338
47BLK0.81011145
48FGFR30.80593077
49LYN0.79211805
50CSNK1G10.78551052
51WNK10.77861805
52YES10.77013161
53BRD40.76576441
54PLK20.72199309
55CDK60.72178364
56VRK10.71443253
57MAP2K60.68123212
58ATR0.65182002
59LCK0.62793921
60JAK20.61331755
61MAP2K30.59936891
62ZAP700.59418180
63CDK120.58429844
64CDC70.57879946
65CSNK1A1L0.56052119
66MAPK120.55985599
67HCK0.55694120
68RPS6KA40.55692929
69FES0.55534551
70RPS6KA50.54884461
71MAPK110.53583746
72CAMKK20.53525660
73PHKG20.52472224
74PHKG10.52472224
75PRKG10.51764115
76MAP3K140.51231446
77STK30.50064281
78MARK30.49657583
79RPS6KB20.48360752
80CCNB10.47012032
81IRAK10.46665588
82EGFR0.46605638
83ADRBK20.46088377
84IGF1R0.45422967
85CHUK0.44337143
86NEK60.44312945
87AKT30.42838121
88MAP3K50.42542209
89ABL10.41352680
90CSNK1G30.40505796
91MAPK70.39597809
92BRSK20.39183715
93INSRR0.38385827
94MAP3K70.38071025
95JAK30.36978975
96KDR0.36917737
97AURKB0.36523296
98ATM0.36210106
99PDK20.36138996
100EIF2AK30.35252978

Predicted pathways (KEGG)

RankGene SetZ-score
1Asthma_Homo sapiens_hsa053105.57709597
2Graft-versus-host disease_Homo sapiens_hsa053324.26903665
3Allograft rejection_Homo sapiens_hsa053304.19906373
4Intestinal immune network for IgA production_Homo sapiens_hsa046724.02197136
5Autoimmune thyroid disease_Homo sapiens_hsa053204.00907390
6Type I diabetes mellitus_Homo sapiens_hsa049403.46078977
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053213.02179581
8Leishmaniasis_Homo sapiens_hsa051402.56182362
9Antigen processing and presentation_Homo sapiens_hsa046122.41685246
10Staphylococcus aureus infection_Homo sapiens_hsa051502.29284214
11Viral myocarditis_Homo sapiens_hsa054162.27282662
12Proteasome_Homo sapiens_hsa030501.94829260
13Systemic lupus erythematosus_Homo sapiens_hsa053221.80027527
14Non-homologous end-joining_Homo sapiens_hsa034501.79473974
15Rheumatoid arthritis_Homo sapiens_hsa053231.73984008
16Fanconi anemia pathway_Homo sapiens_hsa034601.66520912
17Hematopoietic cell lineage_Homo sapiens_hsa046401.63049380
18Herpes simplex infection_Homo sapiens_hsa051681.46339088
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.44826262
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.39034855
21Platelet activation_Homo sapiens_hsa046111.36750034
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33310731
23Toxoplasmosis_Homo sapiens_hsa051451.33119508
24Primary immunodeficiency_Homo sapiens_hsa053401.30083042
25Caffeine metabolism_Homo sapiens_hsa002321.18231660
26Influenza A_Homo sapiens_hsa051641.16847237
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15119030
28Circadian rhythm_Homo sapiens_hsa047101.14034236
29Phototransduction_Homo sapiens_hsa047441.13262097
30Tuberculosis_Homo sapiens_hsa051521.08943614
31RNA degradation_Homo sapiens_hsa030181.08227393
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.99006217
33Epstein-Barr virus infection_Homo sapiens_hsa051690.93385808
34Propanoate metabolism_Homo sapiens_hsa006400.88027876
35Jak-STAT signaling pathway_Homo sapiens_hsa046300.80705071
36Homologous recombination_Homo sapiens_hsa034400.77146358
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.76982023
38NF-kappa B signaling pathway_Homo sapiens_hsa040640.74624973
39Mismatch repair_Homo sapiens_hsa034300.72761964
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70573399
41One carbon pool by folate_Homo sapiens_hsa006700.70120177
42Base excision repair_Homo sapiens_hsa034100.69255141
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69059078
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68347068
45SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68336348
46Linoleic acid metabolism_Homo sapiens_hsa005910.66242716
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65660001
48Tryptophan metabolism_Homo sapiens_hsa003800.61738212
49RNA polymerase_Homo sapiens_hsa030200.61507900
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.61240125
51Salivary secretion_Homo sapiens_hsa049700.60699177
52Measles_Homo sapiens_hsa051620.59238638
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.58460700
54T cell receptor signaling pathway_Homo sapiens_hsa046600.55461538
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50528040
56RNA transport_Homo sapiens_hsa030130.49283500
57Nitrogen metabolism_Homo sapiens_hsa009100.49166483
58Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.47124592
59Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46931529
60Olfactory transduction_Homo sapiens_hsa047400.46261810
61Arachidonic acid metabolism_Homo sapiens_hsa005900.45799903
62Legionellosis_Homo sapiens_hsa051340.45248580
63Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41774259
64Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41763090
65Cysteine and methionine metabolism_Homo sapiens_hsa002700.41734767
66Ether lipid metabolism_Homo sapiens_hsa005650.41045230
67Basal transcription factors_Homo sapiens_hsa030220.40185121
68B cell receptor signaling pathway_Homo sapiens_hsa046620.40079871
69Oocyte meiosis_Homo sapiens_hsa041140.37132082
70Phagosome_Homo sapiens_hsa041450.36906294
71Osteoclast differentiation_Homo sapiens_hsa043800.36888295
72Pancreatic secretion_Homo sapiens_hsa049720.35437221
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35329837
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34491484
75Pertussis_Homo sapiens_hsa051330.33767371
76Peroxisome_Homo sapiens_hsa041460.32843744
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.32293669
78Steroid hormone biosynthesis_Homo sapiens_hsa001400.30684688
79Protein export_Homo sapiens_hsa030600.29402462
80Taste transduction_Homo sapiens_hsa047420.29187376
81HTLV-I infection_Homo sapiens_hsa051660.28412839
82TNF signaling pathway_Homo sapiens_hsa046680.26716520
83Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26218119
84Butanoate metabolism_Homo sapiens_hsa006500.26068799
85Vascular smooth muscle contraction_Homo sapiens_hsa042700.26056635
86Nucleotide excision repair_Homo sapiens_hsa034200.25552526
87Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25039944
88Regulation of autophagy_Homo sapiens_hsa041400.23492875
89Cell cycle_Homo sapiens_hsa041100.22984000
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.22867540
91DNA replication_Homo sapiens_hsa030300.22231795
92Purine metabolism_Homo sapiens_hsa002300.21780101
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.21733727
94Chemical carcinogenesis_Homo sapiens_hsa052040.21547169
95mRNA surveillance pathway_Homo sapiens_hsa030150.20999360
96Long-term depression_Homo sapiens_hsa047300.20741653
97Calcium signaling pathway_Homo sapiens_hsa040200.19266044
98Lysine degradation_Homo sapiens_hsa003100.19168906
99Alcoholism_Homo sapiens_hsa050340.18623355
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.18304290

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