MFSD2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transmembrane protein and sodium-dependent lysophosphatidylcholine transporter. The encoded protein is involved in the establishment of the blood-brain barrier and is required for brain growth and function. Defects in this gene are a cause of a progressive microcephaly syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.74338932
2L-phenylalanine catabolic process (GO:0006559)6.74338932
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.47492178
4L-phenylalanine metabolic process (GO:0006558)6.32894119
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.32894119
6alpha-linolenic acid metabolic process (GO:0036109)6.03913970
7aromatic amino acid family catabolic process (GO:0009074)5.98413650
8regulation of vitamin D biosynthetic process (GO:0060556)5.47383898
9high-density lipoprotein particle remodeling (GO:0034375)5.37650533
10indole-containing compound catabolic process (GO:0042436)5.20436606
11indolalkylamine catabolic process (GO:0046218)5.20436606
12tryptophan catabolic process (GO:0006569)5.20436606
13glyoxylate metabolic process (GO:0046487)5.06750298
14bile acid biosynthetic process (GO:0006699)5.06704421
15kynurenine metabolic process (GO:0070189)5.06621662
16epoxygenase P450 pathway (GO:0019373)4.96513182
17regulation of cholesterol esterification (GO:0010872)4.95193400
18tryptophan metabolic process (GO:0006568)4.90270076
19reverse cholesterol transport (GO:0043691)4.85607924
20cysteine metabolic process (GO:0006534)4.85000013
21urea metabolic process (GO:0019627)4.84889926
22urea cycle (GO:0000050)4.84889926
23regulation of podosome assembly (GO:0071801)4.81081555
24regulation of vitamin metabolic process (GO:0030656)4.79774689
25positive regulation of heterotypic cell-cell adhesion (GO:0034116)4.78781269
26sulfur amino acid catabolic process (GO:0000098)4.75251766
27negative regulation of fibrinolysis (GO:0051918)4.61100452
28plasma lipoprotein particle remodeling (GO:0034369)4.58662168
29protein-lipid complex remodeling (GO:0034368)4.58662168
30macromolecular complex remodeling (GO:0034367)4.58662168
31regulation of triglyceride catabolic process (GO:0010896)4.57694120
32negative regulation of sterol transport (GO:0032372)4.56842591
33negative regulation of cholesterol transport (GO:0032375)4.56842591
34omega-hydroxylase P450 pathway (GO:0097267)4.51944472
35positive regulation of chemokine biosynthetic process (GO:0045080)4.50696152
36phospholipid efflux (GO:0033700)4.50416142
37regulation of fibrinolysis (GO:0051917)4.48315258
38protein carboxylation (GO:0018214)4.47190935
39peptidyl-glutamic acid carboxylation (GO:0017187)4.47190935
40nitrogen cycle metabolic process (GO:0071941)4.44315557
41serine family amino acid catabolic process (GO:0009071)4.41264355
42cellular ketone body metabolic process (GO:0046950)4.40403306
43bile acid metabolic process (GO:0008206)4.39616562
44tyrosine metabolic process (GO:0006570)4.33620377
45fat-soluble vitamin biosynthetic process (GO:0042362)4.31961061
46fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.28543073
47aromatic amino acid family metabolic process (GO:0009072)4.24644589
48regulation of cytokine secretion involved in immune response (GO:0002739)4.24306948
49amino-acid betaine metabolic process (GO:0006577)4.21053712
50regulation of fever generation (GO:0031620)4.16919573
51regulation of protein activation cascade (GO:2000257)4.15493792
52alpha-amino acid catabolic process (GO:1901606)4.12075607
53triglyceride homeostasis (GO:0070328)4.11276839
54acylglycerol homeostasis (GO:0055090)4.11276839
55glutamate metabolic process (GO:0006536)4.11195140
56lysine metabolic process (GO:0006553)4.07236498
57lysine catabolic process (GO:0006554)4.07236498
58amine catabolic process (GO:0009310)4.06749260
59cellular biogenic amine catabolic process (GO:0042402)4.06749260
60drug catabolic process (GO:0042737)4.05771459
61complement activation, alternative pathway (GO:0006957)4.03950006
62low-density lipoprotein particle remodeling (GO:0034374)4.01805940
63plasma lipoprotein particle clearance (GO:0034381)3.98803404
64cholesterol efflux (GO:0033344)3.98292469
65negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.88557748
66short-chain fatty acid metabolic process (GO:0046459)3.88477041
67cellular modified amino acid catabolic process (GO:0042219)3.88288626
68arginine metabolic process (GO:0006525)3.87957480
69regulation of chemokine biosynthetic process (GO:0045073)3.86800770
70cellular amino acid catabolic process (GO:0009063)3.85675569
71ketone body metabolic process (GO:1902224)3.84232332
72regulation of chronic inflammatory response (GO:0002676)3.83637600
73homocysteine metabolic process (GO:0050667)3.82945595
74regulation of complement activation (GO:0030449)3.82317780
75plasma lipoprotein particle assembly (GO:0034377)3.82219151
76positive regulation of heat generation (GO:0031652)3.81586797
77cellular glucuronidation (GO:0052695)3.81382048
78ethanol oxidation (GO:0006069)3.79714553
79acute-phase response (GO:0006953)3.79650211
80linoleic acid metabolic process (GO:0043651)3.79146426
81very long-chain fatty acid metabolic process (GO:0000038)3.78374852
82negative regulation of lipase activity (GO:0060192)3.75881555
83acetyl-CoA metabolic process (GO:0006084)3.70248725
84bile acid and bile salt transport (GO:0015721)3.69684593
85fibrinolysis (GO:0042730)3.69217526
86coenzyme catabolic process (GO:0009109)3.67524036
87regulation of bile acid biosynthetic process (GO:0070857)3.66050654
88indolalkylamine metabolic process (GO:0006586)3.63191555
89positive regulation of lipid catabolic process (GO:0050996)3.62193267
90urate metabolic process (GO:0046415)3.61203429
91dicarboxylic acid biosynthetic process (GO:0043650)3.56930534
92phospholipid homeostasis (GO:0055091)3.53282785
93glycosphingolipid catabolic process (GO:0046479)3.53160985
94very-low-density lipoprotein particle assembly (GO:0034379)3.52047175
95regulation of cholesterol homeostasis (GO:2000188)3.52001723
96serine family amino acid metabolic process (GO:0009069)3.51671349
97cholesterol homeostasis (GO:0042632)3.50675549
98regulation of heterotypic cell-cell adhesion (GO:0034114)3.50214479
99adhesion of symbiont to host cell (GO:0044650)3.49967600
100virion attachment to host cell (GO:0019062)3.49967600
101heme transport (GO:0015886)3.49928274
102plasma lipoprotein particle organization (GO:0071827)3.49751078
103glucuronate metabolic process (GO:0019585)3.48001280
104uronic acid metabolic process (GO:0006063)3.48001280
105benzene-containing compound metabolic process (GO:0042537)3.47235358
106sterol homeostasis (GO:0055092)3.47054194
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.46927888
108regulation of immunoglobulin secretion (GO:0051023)3.43664478
109protein-lipid complex assembly (GO:0065005)3.43470312
110drug transmembrane transport (GO:0006855)3.42736129
111flavonoid metabolic process (GO:0009812)3.42709395
112positive regulation of lipoprotein lipase activity (GO:0051006)3.40888082
113positive regulation of triglyceride lipase activity (GO:0061365)3.40888082
114activation of MAPKKK activity (GO:0000185)3.40712008
115carboxylic acid catabolic process (GO:0046395)3.39148969
116organic acid catabolic process (GO:0016054)3.39148969
117positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.38466326
118exogenous drug catabolic process (GO:0042738)3.38201180
119serine family amino acid biosynthetic process (GO:0009070)3.35784841
120lipoprotein metabolic process (GO:0042157)3.35569657
121regulation of cholesterol biosynthetic process (GO:0045540)3.35498561
122regulation of mononuclear cell migration (GO:0071675)3.32881772
123imidazole-containing compound metabolic process (GO:0052803)3.32758051
124response to peptidoglycan (GO:0032494)3.31128809
125negative regulation of interleukin-12 production (GO:0032695)3.23293333
126lipopolysaccharide-mediated signaling pathway (GO:0031663)3.22728570
127drug metabolic process (GO:0017144)3.21417335
128regulation of membrane protein ectodomain proteolysis (GO:0051043)3.19269937
129glycolipid catabolic process (GO:0019377)3.17521854
130positive regulation of nitric oxide biosynthetic process (GO:0045429)3.16534637
131adhesion of symbiont to host (GO:0044406)3.15499262
132branching involved in labyrinthine layer morphogenesis (GO:0060670)3.14496854
133positive regulation of fatty acid biosynthetic process (GO:0045723)3.14352297
134regulation of retinoic acid receptor signaling pathway (GO:0048385)3.14084092
135oligosaccharide catabolic process (GO:0009313)3.11773063
136regulation of nitric oxide biosynthetic process (GO:0045428)3.09595177
137regulation of heat generation (GO:0031650)3.06155233
138complement activation (GO:0006956)3.03322593
139negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.98231391
140T-helper 1 type immune response (GO:0042088)2.97055065
141positive regulation of extracellular matrix organization (GO:1903055)2.95956266
142positive regulation of humoral immune response (GO:0002922)2.95335838
143angiotensin maturation (GO:0002003)2.91207889
144monocyte chemotaxis (GO:0002548)2.87835004
145regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.87601012
146negative regulation of blood coagulation (GO:0030195)2.83743296
147negative regulation of hemostasis (GO:1900047)2.83743296
148cellular response to thyroid hormone stimulus (GO:0097067)2.82424562
149NIK/NF-kappaB signaling (GO:0038061)2.81663888
150protein activation cascade (GO:0072376)2.80946451
151negative regulation of nitric oxide biosynthetic process (GO:0045019)2.80571540
152negative regulation of growth of symbiont in host (GO:0044130)2.76043695
153negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.76043695
154modulation of growth of symbiont involved in interaction with host (GO:0044144)2.76043695
155regulation of growth of symbiont in host (GO:0044126)2.76043695
156hydrogen peroxide biosynthetic process (GO:0050665)2.74533731
157positive regulation of NF-kappaB import into nucleus (GO:0042346)2.73435505
158CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.70675908
159regulation of humoral immune response (GO:0002920)2.70483917
160negative regulation of coagulation (GO:0050819)2.67525859
161negative regulation of fatty acid biosynthetic process (GO:0045717)2.67459975
162ceramide catabolic process (GO:0046514)2.67292787
163positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.66614167
164complement activation, classical pathway (GO:0006958)2.66462794
165positive regulation of acute inflammatory response (GO:0002675)2.65536154
166response to protozoan (GO:0001562)2.65297643
167macrophage activation involved in immune response (GO:0002281)2.64452892
168myeloid dendritic cell differentiation (GO:0043011)2.64452329

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse9.27921823
2* RXR_22158963_ChIP-Seq_LIVER_Mouse6.45100788
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.60093135
4PPARA_22158963_ChIP-Seq_LIVER_Mouse5.37071140
5* LXR_22158963_ChIP-Seq_LIVER_Mouse5.18230124
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.96625289
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.08756940
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.64583749
9CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.28879941
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.27730979
11IRF8_21731497_ChIP-ChIP_J774_Mouse3.23485642
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.93106631
13NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.92827030
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.69151159
15EGR1_19374776_ChIP-ChIP_THP-1_Human2.68962992
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.67191030
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.63120605
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.63120605
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.63120605
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.36581691
21Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.34326738
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23714609
23NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.10812727
24IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.95091237
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.91823182
26STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.78340891
27TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.73484660
28MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72484756
29* VDR_24787735_ChIP-Seq_THP-1_Human1.67829068
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.66639736
31CLOCK_20551151_ChIP-Seq_293T_Human1.62202396
32STAT4_19710469_ChIP-ChIP_TH1__Mouse1.61691071
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57267752
34VDR_24763502_ChIP-Seq_THP-1_Human1.55720454
35FOXA2_19822575_ChIP-Seq_HepG2_Human1.54566143
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.53064634
37IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.52858387
38VDR_21846776_ChIP-Seq_THP-1_Human1.52642773
39PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.51559500
40AR_21572438_ChIP-Seq_LNCaP_Human1.47484129
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.47140262
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.46407018
43TRIM28_21343339_ChIP-Seq_HEK293_Human1.44401339
44* LXR_22292898_ChIP-Seq_THP-1_Human1.36377066
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.30948867
46HTT_18923047_ChIP-ChIP_STHdh_Human1.29453821
47HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27305008
48TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23523475
49MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.23383921
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22194729
51EED_16625203_ChIP-ChIP_MESCs_Mouse1.20005542
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19494883
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18722551
54SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18150576
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.17539406
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14952609
57SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.12839060
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.10924920
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.09482330
60PIAS1_25552417_ChIP-Seq_VCAP_Human1.07765410
61NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.07572352
62TAF15_26573619_Chip-Seq_HEK293_Human1.07358260
63HNF4A_19822575_ChIP-Seq_HepG2_Human1.06052319
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.05126062
65NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.04877847
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04363188
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03194899
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03194899
69ESR1_21235772_ChIP-Seq_MCF-7_Human1.03120370
70PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03063597
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02317626
72GBX2_23144817_ChIP-Seq_PC3_Human1.02171580
73SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02099256
74BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.01173148
75MTF2_20144788_ChIP-Seq_MESCs_Mouse1.00956955
76RNF2_18974828_ChIP-Seq_MESCs_Mouse0.99706174
77EZH2_18974828_ChIP-Seq_MESCs_Mouse0.99706174
78VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99567743
79E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99374971
80ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99265294
81AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99047422
82STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98561111
83STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.98264709
84TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.97997734
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.97723861
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97639601
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97375326
88SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.96099672
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.95887965
90ESR1_20079471_ChIP-ChIP_T-47D_Human0.95729428
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94692073
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93232059
93ERG_21242973_ChIP-ChIP_JURKAT_Human0.93150990
94CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91200478
95SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.90826567
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.89726876
97SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.88866161
98* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.88774625
99GATA4_25053715_ChIP-Seq_YYC3_Human0.88354042
100UBF1/2_26484160_Chip-Seq_HMECs_Human0.87710538
101AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86627243
102GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.86015240
103BCAT_22108803_ChIP-Seq_LS180_Human0.85242251
104BCOR_27268052_Chip-Seq_Bcells_Human0.84760909
105SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84245090
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.83838458
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83548410
108RXR_22108803_ChIP-Seq_LS180_Human0.83107923
109SCL_19346495_ChIP-Seq_HPC-7_Human0.82221833
110AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.82085569
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.81767179
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.80474599
113SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80074298
114SMAD_19615063_ChIP-ChIP_OVARY_Human0.78488857
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.78280269
116* RACK7_27058665_Chip-Seq_MCF-7_Human0.78040082
117KDM2B_26808549_Chip-Seq_K562_Human0.77872732
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.77142526
119TCF7_22412390_ChIP-Seq_EML_Mouse0.77097946
120PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.76924337
121RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.76420128
122EZH2_27294783_Chip-Seq_ESCs_Mouse0.75282210
123* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74783397
124JARID2_20064375_ChIP-Seq_MESCs_Mouse0.74530778
125GATA1_22025678_ChIP-Seq_K562_Human0.74317101
126SUZ12_27294783_Chip-Seq_ESCs_Mouse0.74271812
127EGR1_19032775_ChIP-ChIP_M12_Human0.73945693
128RUNX1_22412390_ChIP-Seq_EML_Mouse0.73800082
129SMAD4_21741376_ChIP-Seq_HESCs_Human0.73775031
130SOX2_20726797_ChIP-Seq_SW620_Human0.73471588
131BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.72598178
132PU_27001747_Chip-Seq_BMDM_Mouse0.72382715
133CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72226785
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.71975320
135PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.71968111
136JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.71410761
137P63_26484246_Chip-Seq_KERATINOCYTES_Human0.70952223
138SMAD4_21741376_ChIP-Seq_EPCs_Human0.70251456
139ZNF263_19887448_ChIP-Seq_K562_Human0.70041973
140PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.69593780
141* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.68892641
142SPI1_23127762_ChIP-Seq_K562_Human0.68613304
143PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68154464
144EZH2_27304074_Chip-Seq_ESCs_Mouse0.67087388
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.65752226
146SOX9_24532713_ChIP-Seq_HFSC_Mouse0.63200769
147* TP63_23658742_ChIP-Seq_EP156T_Human0.63084136
148FOXA1_25552417_ChIP-Seq_VCAP_Human0.61602034
149RARG_19884340_ChIP-ChIP_MEFs_Mouse0.61396875
150SMAD3_21741376_ChIP-Seq_HESCs_Human0.61112303
151* SMAD3_21741376_ChIP-Seq_EPCs_Human0.60825447
152ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.60434893
153MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.60349291
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.60323350
155CBP_21632823_ChIP-Seq_H3396_Human0.60084361
156FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59880696
157CDX2_22108803_ChIP-Seq_LS180_Human0.59326063
158FOXM1_26456572_ChIP-Seq_MCF-7_Human0.58481838
159EP300_21415370_ChIP-Seq_HL-1_Mouse0.58283518
160GATA1_19941826_ChIP-Seq_K562_Human0.57887709
161MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.57077966
162AHR_22903824_ChIP-Seq_MCF-7_Human0.57044711
163CTBP2_25329375_ChIP-Seq_LNCAP_Human0.56899386
164NR3C1_21868756_ChIP-Seq_MCF10A_Human0.56691583
165CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.56440963
166RNF2_27304074_Chip-Seq_ESCs_Mouse0.56146444
167CJUN_26792858_Chip-Seq_BT549_Human0.56048307
168RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.55967263

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.99300644
2MP0005360_urolithiasis7.25669219
3MP0005085_abnormal_gallbladder_physiolo6.01177783
4MP0005365_abnormal_bile_salt5.45753910
5MP0008875_abnormal_xenobiotic_pharmacok5.16515873
6MP0003303_peritoneal_inflammation4.47225307
7MP0010329_abnormal_lipoprotein_level3.41068473
8MP0003252_abnormal_bile_duct3.32175442
9MP0009840_abnormal_foam_cell3.31776079
10MP0003806_abnormal_nucleotide_metabolis3.13437126
11MP0005083_abnormal_biliary_tract2.81942705
12MP0005332_abnormal_amino_acid2.81344736
13MP0005058_abnormal_lysosome_morphology2.65284909
14MP0002148_abnormal_hypersensitivity_rea2.63026501
15MP0006082_CNS_inflammation2.62640377
16MP0009785_altered_susceptibility_to2.60668226
17MP0001666_abnormal_nutrient_absorption2.54536867
18MP0003436_decreased_susceptibility_to2.35390769
19MP0003195_calcinosis2.28228728
20MP0004510_myositis2.17415862
21MP0004019_abnormal_vitamin_homeostasis2.09396627
22MP0003868_abnormal_feces_composition2.07556321
23MP0002118_abnormal_lipid_homeostasis2.05694821
24MP0000343_altered_response_to1.96976027
25MP0003191_abnormal_cellular_cholesterol1.95639932
26MP0003724_increased_susceptibility_to1.94136838
27MP0000609_abnormal_liver_physiology1.82636925
28MP0002419_abnormal_innate_immunity1.81522718
29MP0005025_abnormal_response_to1.78923090
30MP0008004_abnormal_stomach_pH1.78525901
31MP0005387_immune_system_phenotype1.75180305
32MP0001790_abnormal_immune_system1.75180305
33MP0002138_abnormal_hepatobiliary_system1.74355882
34MP0005166_decreased_susceptibility_to1.71570508
35MP0005000_abnormal_immune_tolerance1.67420273
36MP0004947_skin_inflammation1.63715208
37MP0010155_abnormal_intestine_physiology1.58975788
38MP0009697_abnormal_copulation1.56848446
39MP0003690_abnormal_glial_cell1.55895455
40MP0005451_abnormal_body_composition1.50990584
41MP0002254_reproductive_system_inflammat1.48301774
42MP0001835_abnormal_antigen_presentation1.47820967
43MP0005647_abnormal_sex_gland1.40724033
44MP0005319_abnormal_enzyme/_coenzyme1.39931379
45MP0005584_abnormal_enzyme/coenzyme_acti1.39812382
46MP0001845_abnormal_inflammatory_respons1.34708185
47MP0002332_abnormal_exercise_endurance1.34097617
48MP0000604_amyloidosis1.33642216
49MP0001853_heart_inflammation1.33379660
50MP0003329_amyloid_beta_deposits1.31788614
51MP0002723_abnormal_immune_serum1.31489973
52MP0000566_synostosis1.29528041
53MP0001533_abnormal_skeleton_physiology1.28152848
54MP0003011_delayed_dark_adaptation1.27550270
55MP0002452_abnormal_antigen_presenting1.26929688
56MP0001800_abnormal_humoral_immune1.26509850
57MP0005671_abnormal_response_to1.26300245
58MP0002998_abnormal_bone_remodeling1.22919164
59MP0003448_altered_tumor_morphology1.18262907
60MP0009643_abnormal_urine_homeostasis1.18090500
61MP0001545_abnormal_hematopoietic_system1.14533679
62MP0005397_hematopoietic_system_phenotyp1.14533679
63MP0001764_abnormal_homeostasis1.09471203
64MP0005408_hypopigmentation1.07973904
65MP0002405_respiratory_system_inflammati1.04785440
66MP0009333_abnormal_splenocyte_physiolog1.03508158
67MP0001501_abnormal_sleep_pattern1.02448424
68MP0009764_decreased_sensitivity_to1.02332167
69MP0005023_abnormal_wound_healing1.01754393
70MP0005167_abnormal_blood-brain_barrier0.99085583
71MP0002796_impaired_skin_barrier0.98938317
72MP0009384_cardiac_valve_regurgitation0.98270968
73MP0005084_abnormal_gallbladder_morpholo0.95382115
74MP0009278_abnormal_bone_marrow0.95036536
75MP0005670_abnormal_white_adipose0.92577090
76MP0008260_abnormal_autophagy0.92520989
77MP0001661_extended_life_span0.92083203
78MP0001851_eye_inflammation0.91980782
79MP0002420_abnormal_adaptive_immunity0.91340302
80MP0001819_abnormal_immune_cell0.90913928
81MP0003183_abnormal_peptide_metabolism0.90266546
82MP0003705_abnormal_hypodermis_morpholog0.87382901
83MP0009379_abnormal_foot_pigmentation0.85701858
84MP0000598_abnormal_liver_morphology0.85567129
85MP0005310_abnormal_salivary_gland0.84074661
86MP0003718_maternal_effect0.83465786
87MP0003091_abnormal_cell_migration0.83453757
88MP0000858_altered_metastatic_potential0.83152938
89MP0010368_abnormal_lymphatic_system0.78275662
90MP0003186_abnormal_redox_activity0.77325921
91MP0010307_abnormal_tumor_latency0.76817965
92MP0009763_increased_sensitivity_to0.76093044
93MP0005636_abnormal_mineral_homeostasis0.74793674
94MP0005409_darkened_coat_color0.74537358
95MP0009765_abnormal_xenobiotic_induced0.74059483
96MP0003638_abnormal_response/metabolism_0.73746852
97MP0000685_abnormal_immune_system0.73203468
98MP0004381_abnormal_hair_follicle0.71348194
99MP0002971_abnormal_brown_adipose0.70305331
100MP0010678_abnormal_skin_adnexa0.70065111
101MP0001216_abnormal_epidermal_layer0.69776667
102MP0002295_abnormal_pulmonary_circulatio0.68965882
103MP0003950_abnormal_plasma_membrane0.68418555
104MP0004885_abnormal_endolymph0.68272197
105MP0009642_abnormal_blood_homeostasis0.66929943
106MP0000920_abnormal_myelination0.66759453
107MP0000467_abnormal_esophagus_morphology0.65919609
108MP0005395_other_phenotype0.64823215
109MP0010234_abnormal_vibrissa_follicle0.62686379
110MP0005376_homeostasis/metabolism_phenot0.62420677
111MP0000716_abnormal_immune_system0.62101888
112MP0004272_abnormal_basement_membrane0.61451396
113MP0005666_abnormal_adipose_tissue0.61393814
114MP0003879_abnormal_hair_cell0.61028101
115MP0000647_abnormal_sebaceous_gland0.61002281
116MP0005646_abnormal_pituitary_gland0.60588617
117MP0004130_abnormal_muscle_cell0.59927123
118MP0000639_abnormal_adrenal_gland0.58242796
119MP0003172_abnormal_lysosome_physiology0.57344667
120MP0002876_abnormal_thyroid_physiology0.56283257
121MP0008874_decreased_physiological_sensi0.55562795
122MP0000383_abnormal_hair_follicle0.55147327
123MP0005535_abnormal_body_temperature0.54646307
124MP0002078_abnormal_glucose_homeostasis0.53979833
125MP0003656_abnormal_erythrocyte_physiolo0.53287006
126MP0001756_abnormal_urination0.52493858
127MP0001879_abnormal_lymphatic_vessel0.52152700
128MP0002249_abnormal_larynx_morphology0.52129202
129MP0003453_abnormal_keratinocyte_physiol0.50628916
130MP0005334_abnormal_fat_pad0.49808646
131MP0003300_gastrointestinal_ulcer0.49572933
132MP0009053_abnormal_anal_canal0.49217232
133MP0005595_abnormal_vascular_smooth0.48989700
134MP0000249_abnormal_blood_vessel0.48309643
135MP0003941_abnormal_skin_development0.47702878
136MP0004782_abnormal_surfactant_physiolog0.47672866
137MP0004883_abnormal_blood_vessel0.47420457
138MP0002136_abnormal_kidney_physiology0.46949059
139MP0000462_abnormal_digestive_system0.46838583
140MP0008469_abnormal_protein_level0.46311235
141MP0002098_abnormal_vibrissa_morphology0.45448338
142MP0003075_altered_response_to0.44842341
143MP0005220_abnormal_exocrine_pancreas0.44718583
144MP0002822_catalepsy0.44196262
145MP0000230_abnormal_systemic_arterial0.43949830
146MP0005164_abnormal_response_to0.43483408
147MP0004185_abnormal_adipocyte_glucose0.42266763
148MP0005248_abnormal_Harderian_gland0.40067622
149MP0005165_increased_susceptibility_to0.39287529
150MP0002090_abnormal_vision0.39211161
151MP0004147_increased_porphyrin_level0.39204316
152MP0005266_abnormal_metabolism0.38508453

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)7.17021024
2Systemic lupus erythematosus (HP:0002725)6.75674571
3Abnormality of aromatic amino acid family metabolism (HP:0004338)6.61753484
4Intrahepatic cholestasis (HP:0001406)6.47662112
5Xanthomatosis (HP:0000991)6.37837327
6Abnormality of monocarboxylic acid metabolism (HP:0010996)6.06939622
7Hyperlipoproteinemia (HP:0010980)6.01550976
8Hypobetalipoproteinemia (HP:0003563)5.96746626
9Prolonged partial thromboplastin time (HP:0003645)5.65617960
10Abnormality of liposaccharide metabolism (HP:0010968)5.22055293
11Abnormality of glycosphingolipid metabolism (HP:0004343)5.22055293
12Abnormality of glycolipid metabolism (HP:0010969)5.22055293
13Hypolipoproteinemia (HP:0010981)4.66303983
14Hyperammonemia (HP:0001987)4.38974263
15Ketosis (HP:0001946)4.37795132
16Hypoalphalipoproteinemia (HP:0003233)4.37205311
17Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.31273056
18Recurrent gram-negative bacterial infections (HP:0005420)4.14085312
19Epidermoid cyst (HP:0200040)4.12108074
20Abnormality of glutamine family amino acid metabolism (HP:0010902)4.09228927
21Hyperglycinemia (HP:0002154)4.07440180
22Hyperglycinuria (HP:0003108)4.06646460
23Abnormality of glycine metabolism (HP:0010895)4.05099390
24Abnormality of serine family amino acid metabolism (HP:0010894)4.05099390
25Vacuolated lymphocytes (HP:0001922)4.03823707
26Abnormality of aspartate family amino acid metabolism (HP:0010899)4.01001299
27Complement deficiency (HP:0004431)3.99732203
28Abnormality of methionine metabolism (HP:0010901)3.94331635
29Abnormality of sulfur amino acid metabolism (HP:0004339)3.93442651
30Loss of speech (HP:0002371)3.92233955
31Joint hemorrhage (HP:0005261)3.91763854
32Hypoglycemic coma (HP:0001325)3.85751849
33Abnormality of the common coagulation pathway (HP:0010990)3.74754465
34Increased cerebral lipofuscin (HP:0011813)3.53350926
35Hypercholesterolemia (HP:0003124)3.49746963
36Fat malabsorption (HP:0002630)3.47214267
37Delayed CNS myelination (HP:0002188)3.43011338
38Ketoacidosis (HP:0001993)3.23178158
39Abnormality of macrophages (HP:0004311)3.21791480
40Interstitial pulmonary disease (HP:0006530)3.15190052
41Nephritis (HP:0000123)3.11691429
42Conjugated hyperbilirubinemia (HP:0002908)3.11647125
43Disinhibition (HP:0000734)3.11214768
44Mutism (HP:0002300)3.05400046
45Abnormality of purine metabolism (HP:0004352)3.01644342
46Abnormality of nucleobase metabolism (HP:0010932)2.98849452
47Abnormality of the intrinsic pathway (HP:0010989)2.97540584
48Nuclear cataract (HP:0100018)2.97510301
49Myocardial infarction (HP:0001658)2.96432971
50Optic neuritis (HP:0100653)2.96116447
51Retrobulbar optic neuritis (HP:0100654)2.96116447
52Abnormality of fatty-acid metabolism (HP:0004359)2.95279081
53Orchitis (HP:0100796)2.94317143
54Abnormality of pyrimidine metabolism (HP:0004353)2.93259672
55Increased neuronal autofluorescent lipopigment (HP:0002074)2.86644652
56Axonal loss (HP:0003447)2.84591774
57Malnutrition (HP:0004395)2.81855304
58Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.81053502
59Dysostosis multiplex (HP:0000943)2.80882276
60Increased serum ferritin (HP:0003281)2.78290794
61Esophageal varix (HP:0002040)2.78210728
62Hypoglycemic seizures (HP:0002173)2.78046052
63Hyperbilirubinemia (HP:0002904)2.76947461
64Nausea (HP:0002018)2.74728986
65Abnormality of complement system (HP:0005339)2.72898304
66Eczematoid dermatitis (HP:0000976)2.68505047
67Autoimmune thrombocytopenia (HP:0001973)2.65589426
68Gout (HP:0001997)2.64531472
69Abnormality of serum amino acid levels (HP:0003112)2.61865726
70Vascular calcification (HP:0004934)2.61542996
71Steatorrhea (HP:0002570)2.58378919
72Spontaneous abortion (HP:0005268)2.58293255
73Myositis (HP:0100614)2.54495506
74Hepatocellular carcinoma (HP:0001402)2.51274200
75Metabolic acidosis (HP:0001942)2.51100385
76Stomatitis (HP:0010280)2.49897646
77Hemorrhage of the eye (HP:0011885)2.48901613
78Apathy (HP:0000741)2.48228992
79Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.45103875
80Confusion (HP:0001289)2.44599176
81Neurofibrillary tangles (HP:0002185)2.44498357
82Spastic diplegia (HP:0001264)2.43028912
83Lethargy (HP:0001254)2.41727887
84Abnormality of the vasculature of the conjunctiva (HP:0008054)2.39794633
85Purpura (HP:0000979)2.39683052
86Skin nodule (HP:0200036)2.39562050
87Diminished motivation (HP:0000745)2.38851666
88Gangrene (HP:0100758)2.36139460
89Recurrent abscess formation (HP:0002722)2.34885388
90Mediastinal lymphadenopathy (HP:0100721)2.31557302
91Parakeratosis (HP:0001036)2.31522738
92Recurrent bacterial skin infections (HP:0005406)2.31026650
93Abnormality of the axillary hair (HP:0100134)2.28440964
94Abnormality of secondary sexual hair (HP:0009888)2.28440964
95Cardiovascular calcification (HP:0011915)2.27307388
96Irritability (HP:0000737)2.26782169
97Dicarboxylic aciduria (HP:0003215)2.25761254
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.25761254
99Polygenic inheritance (HP:0010982)2.24431198
100Abnormality of iron homeostasis (HP:0011031)2.23910953
101Peripheral demyelination (HP:0011096)2.22547426
102Abnormality of polysaccharide metabolism (HP:0011012)2.21860970
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.21860970
104Abnormality of mucopolysaccharide metabolism (HP:0011020)2.21860970
105Amyloidosis (HP:0011034)2.20350832
106Neuronal loss in central nervous system (HP:0002529)2.19106207
107Prolonged neonatal jaundice (HP:0006579)2.18327449
108Tetraparesis (HP:0002273)2.17435407
109Hyperinsulinemic hypoglycemia (HP:0000825)2.16918993
110Elevated alkaline phosphatase (HP:0003155)2.15800316
111Enlarged kidneys (HP:0000105)2.12408442
112Cholecystitis (HP:0001082)2.12405230
113Abnormal gallbladder physiology (HP:0012438)2.12405230
114Abnormality of the periventricular white matter (HP:0002518)2.11958464
115Paralysis (HP:0003470)2.10413030
116Pseudobulbar signs (HP:0002200)2.08674225
117Sensorimotor neuropathy (HP:0007141)2.07033797
118Mucopolysacchariduria (HP:0008155)2.04526450
119Urinary glycosaminoglycan excretion (HP:0003541)2.04526450
120Metaphyseal irregularity (HP:0003025)2.04463352
121Hydroxyprolinuria (HP:0003080)2.03438526
122Abnormality of proline metabolism (HP:0010907)2.03438526
123Bone pain (HP:0002653)2.03431983
124Joint swelling (HP:0001386)2.01569152
125Alkalosis (HP:0001948)2.00581862
126Late onset (HP:0003584)2.00259870
127Keratoconjunctivitis sicca (HP:0001097)1.99570629
128Back pain (HP:0003418)1.98968507
129Hypophosphatemic rickets (HP:0004912)1.98894236
130Generalized aminoaciduria (HP:0002909)1.98328396
131Pancreatitis (HP:0001733)1.98021986
132Neonatal onset (HP:0003623)1.97456870
133Mitral stenosis (HP:0001718)1.97068104
134Abnormal gallbladder morphology (HP:0012437)1.96682627
135Rickets (HP:0002748)1.96402701
136Vomiting (HP:0002013)1.94053864
137Abnormality of alkaline phosphatase activity (HP:0004379)1.93958330
138Increased purine levels (HP:0004368)1.93561890
139Hyperuricemia (HP:0002149)1.93561890
140Acanthocytosis (HP:0001927)1.92399813
141Conjunctival telangiectasia (HP:0000524)1.92194101
142Dementia (HP:0000726)1.91867110
143Status epilepticus (HP:0002133)1.91762946
144Bifid scrotum (HP:0000048)1.91669915
145Cerebral edema (HP:0002181)1.90500402
146Abnormal enzyme/coenzyme activity (HP:0012379)1.89306821
147Glomerulonephritis (HP:0000099)1.89114788
148Cerebral inclusion bodies (HP:0100314)1.87675904
149Cholelithiasis (HP:0001081)1.86135178
150Hypochromic microcytic anemia (HP:0004840)1.85831069
151Symptomatic seizures (HP:0011145)1.83933317
152Abnormality of transition element cation homeostasis (HP:0011030)1.82869891
153Widely patent fontanelles and sutures (HP:0004492)1.81862506
154Abnormal cartilage morphology (HP:0002763)1.79587217
155Hypophosphatemia (HP:0002148)1.78868499
156Pulmonary infiltrates (HP:0002113)1.77321294
157Polycythemia (HP:0001901)1.77308954
158Pulmonary embolism (HP:0002204)1.75952606
159Memory impairment (HP:0002354)1.75658988
160Abnormality of vitamin metabolism (HP:0100508)1.74572589
161Abnormality of urine glucose concentration (HP:0011016)1.72933168
162Glycosuria (HP:0003076)1.72933168
163Thrombophlebitis (HP:0004418)1.72361289
164Pathologic fracture (HP:0002756)1.71464422
165Opisthotonus (HP:0002179)1.69995296
166Brushfield spots (HP:0001088)1.69048934

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK35.43681687
2TSSK64.87002548
3BCKDK4.18496424
4SIK13.77258995
5RIPK13.64869308
6NME23.31738191
7KDR3.12077989
8FGFR42.92838448
9TAOK22.83326950
10FGFR22.73884854
11DDR22.71235431
12TBK12.55832325
13TYRO32.55494414
14GRK72.55274728
15MATK2.42317386
16ERBB42.39330079
17PRPF4B2.33244247
18INSRR2.32582082
19TNIK2.26974795
20PIM22.05076239
21PDGFRA2.04125610
22MAP2K41.96617561
23EPHA41.91569142
24EPHB11.90955363
25IKBKB1.81421729
26TIE11.80504268
27ERN11.78089416
28IRAK41.70633801
29PRKAA21.65021521
30BLK1.62457218
31ACVR1B1.57205983
32LATS11.55870726
33BMPR21.54242304
34IKBKE1.52298631
35STK391.49456764
36NTRK21.45994920
37MAP3K21.41346857
38TRIB31.37567557
39OXSR11.34410561
40AKT31.32504302
41MAPK121.31180412
42MST1R1.30806384
43LATS21.27565136
44MUSK1.27331431
45RIPK41.26710078
46GRK11.25276956
47PDGFRB1.24667038
48STK241.24266214
49CDC42BPA1.22776874
50CHUK1.20682397
51IRAK21.20424160
52TYK21.16195616
53EPHB21.12270684
54ABL21.11787296
55TAOK31.11293543
56IRAK11.08422082
57PDK21.07494809
58FES1.07114064
59PRKCQ1.07014748
60PTK61.05177688
61CSK1.05080559
62ICK1.03714033
63KSR21.03408789
64PIM11.02777529
65MAP3K51.02263500
66GSK3A1.01833160
67PKN21.01400701
68MAP3K10.99488338
69MAP3K30.97937829
70NLK0.97115784
71CAMK1D0.96031013
72FRK0.92193881
73ERBB20.91965465
74MAP4K10.90999634
75MAP3K70.90616897
76NUAK10.90249476
77MET0.89398864
78PRKCZ0.87112100
79MAPK70.84223645
80MAPK150.83491856
81CAMK1G0.82567217
82PTK20.80080903
83PIK3CG0.79497785
84MAP3K60.79070873
85ARAF0.77955773
86MAPK110.77308936
87CSNK1G20.74628258
88RET0.73768620
89PAK60.73452768
90CSNK1G10.73367786
91JAK20.72084129
92FGR0.71834261
93NTRK10.71003821
94PKN10.70227985
95PAK30.69597925
96MAP2K10.69141019
97IGF1R0.68903297
98SGK2230.68411465
99SGK4940.68411465
100EPHA30.68217678
101MAP3K130.67988687
102FGFR30.63395139
103PRKACG0.63306441
104JAK30.62021428
105MAPK40.61787072
106ROCK10.59706496
107PRKAA10.59590838
108MAP2K30.57043288
109GRK60.56416363
110BMX0.53223779
111PDPK10.52913221
112STK100.52690419
113WNK40.52470940
114ADRBK20.51783085
115CASK0.51292244
116PTK2B0.50163394
117MYLK0.49463279
118MAP3K90.49091714
119CSNK1A1L0.49091701
120PRKCG0.48730532
121DAPK20.48613091
122ZAP700.47653735
123CSNK1G30.47540504
124CAMK2G0.47294259
125DYRK30.47225172
126PAK40.45614530
127MAP2K20.45518097
128NEK90.45458283
129PBK0.45118078
130CDK60.45017399
131TAOK10.44948688
132FER0.44360748
133MAPK130.43669395
134INSR0.43479707
135PRKCA0.43264014
136PAK20.42689158
137TESK20.41691354
138MAP3K110.41666756
139LYN0.41229953
140TGFBR20.40437912
141MAP2K60.40031581
142MOS0.39959540
143MAP3K140.39162710
144MARK30.34627604
145EGFR0.33781677
146JAK10.31218707
147CSF1R0.28280858
148NEK60.24389463
149RPS6KA10.23874841
150CAMKK20.23195259
151TXK0.18842279
152ABL10.18384481
153LCK0.15666853
154DAPK30.14706269
155DYRK1B0.13671130

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.94009192
2Nitrogen metabolism_Homo sapiens_hsa009103.89706630
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.44786708
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.22111168
5Arginine biosynthesis_Homo sapiens_hsa002203.08748790
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97292676
7Fatty acid degradation_Homo sapiens_hsa000712.54288509
8Tryptophan metabolism_Homo sapiens_hsa003802.45759972
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.40170006
10Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.36686844
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.36251971
12Complement and coagulation cascades_Homo sapiens_hsa046102.32417228
13Butanoate metabolism_Homo sapiens_hsa006502.24406961
14Fatty acid metabolism_Homo sapiens_hsa012122.20839595
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.15407848
16Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.09888523
17Pertussis_Homo sapiens_hsa051332.07766301
18Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07170874
19PPAR signaling pathway_Homo sapiens_hsa033202.04591569
20Peroxisome_Homo sapiens_hsa041462.00484220
21Propanoate metabolism_Homo sapiens_hsa006401.99544655
22Rheumatoid arthritis_Homo sapiens_hsa053231.99216817
23Legionellosis_Homo sapiens_hsa051341.98762099
24Asthma_Homo sapiens_hsa053101.92728175
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.90070476
26Histidine metabolism_Homo sapiens_hsa003401.89320263
27TNF signaling pathway_Homo sapiens_hsa046681.88177798
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.84581612
29Chemical carcinogenesis_Homo sapiens_hsa052041.81783518
30Steroid biosynthesis_Homo sapiens_hsa001001.79239956
31Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78392887
32Bile secretion_Homo sapiens_hsa049761.76969754
33beta-Alanine metabolism_Homo sapiens_hsa004101.69516546
34Fatty acid elongation_Homo sapiens_hsa000621.68146852
35Malaria_Homo sapiens_hsa051441.66699759
36Allograft rejection_Homo sapiens_hsa053301.64160534
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.63409042
38Other glycan degradation_Homo sapiens_hsa005111.63149223
39Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.59099442
40Retinol metabolism_Homo sapiens_hsa008301.55411450
41Leishmaniasis_Homo sapiens_hsa051401.54840614
42Caffeine metabolism_Homo sapiens_hsa002321.54201008
43Lysosome_Homo sapiens_hsa041421.51547157
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.51214447
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.50524445
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.45918591
47Phenylalanine metabolism_Homo sapiens_hsa003601.44827309
48Osteoclast differentiation_Homo sapiens_hsa043801.38970576
49Sulfur relay system_Homo sapiens_hsa041221.38689748
50Sulfur metabolism_Homo sapiens_hsa009201.37174356
512-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33138508
52Pyruvate metabolism_Homo sapiens_hsa006201.32798747
53Tyrosine metabolism_Homo sapiens_hsa003501.28221476
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.27238299
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.26937404
56Staphylococcus aureus infection_Homo sapiens_hsa051501.26218465
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.24394812
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24202553
59Salmonella infection_Homo sapiens_hsa051321.23790010
60Graft-versus-host disease_Homo sapiens_hsa053321.21228934
61Arginine and proline metabolism_Homo sapiens_hsa003301.20996059
62Influenza A_Homo sapiens_hsa051641.19898671
63Autoimmune thyroid disease_Homo sapiens_hsa053201.13428222
64ABC transporters_Homo sapiens_hsa020101.13089422
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12598385
66Fatty acid biosynthesis_Homo sapiens_hsa000611.12515602
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12368784
68Starch and sucrose metabolism_Homo sapiens_hsa005001.11763149
69Fat digestion and absorption_Homo sapiens_hsa049751.11249555
70Folate biosynthesis_Homo sapiens_hsa007901.10967295
71Tuberculosis_Homo sapiens_hsa051521.10241842
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06153350
73Vitamin digestion and absorption_Homo sapiens_hsa049771.04113561
74Cyanoamino acid metabolism_Homo sapiens_hsa004601.03808591
75Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03439593
76Toxoplasmosis_Homo sapiens_hsa051451.02897446
77Selenocompound metabolism_Homo sapiens_hsa004500.98616440
78Biosynthesis of amino acids_Homo sapiens_hsa012300.98029963
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.96812784
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.96623150
81Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.95538679
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.93010418
83Carbon metabolism_Homo sapiens_hsa012000.89394201
84Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86489721
85Lysine degradation_Homo sapiens_hsa003100.86149297
86Glycerolipid metabolism_Homo sapiens_hsa005610.84604780
87Amoebiasis_Homo sapiens_hsa051460.83012007
88Antigen processing and presentation_Homo sapiens_hsa046120.80480094
89Maturity onset diabetes of the young_Homo sapiens_hsa049500.75946103
90Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75449702
91Renin-angiotensin system_Homo sapiens_hsa046140.73443351
92Type I diabetes mellitus_Homo sapiens_hsa049400.67833176
93Jak-STAT signaling pathway_Homo sapiens_hsa046300.67619061
94Hematopoietic cell lineage_Homo sapiens_hsa046400.64128346
95Phagosome_Homo sapiens_hsa041450.61740205
96Vitamin B6 metabolism_Homo sapiens_hsa007500.61626338
97Glutathione metabolism_Homo sapiens_hsa004800.58917716
98Herpes simplex infection_Homo sapiens_hsa051680.58648465
99Bladder cancer_Homo sapiens_hsa052190.55997529
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54462316
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53539697
102Apoptosis_Homo sapiens_hsa042100.51963436
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.51236950
104Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51235234
105B cell receptor signaling pathway_Homo sapiens_hsa046620.50633476
106Measles_Homo sapiens_hsa051620.50039765
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45110415
108Hepatitis B_Homo sapiens_hsa051610.45054202
109AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44964444
110Pentose phosphate pathway_Homo sapiens_hsa000300.44606976
111Chemokine signaling pathway_Homo sapiens_hsa040620.39408923
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.38053524
113Metabolic pathways_Homo sapiens_hsa011000.37771551
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.36839913
115Shigellosis_Homo sapiens_hsa051310.34333320
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.31183637
117Linoleic acid metabolism_Homo sapiens_hsa005910.29403446
118Systemic lupus erythematosus_Homo sapiens_hsa053220.28658692
119Insulin resistance_Homo sapiens_hsa049310.26072032
120Ovarian steroidogenesis_Homo sapiens_hsa049130.25474613
121Prion diseases_Homo sapiens_hsa050200.24954529
122Ether lipid metabolism_Homo sapiens_hsa005650.16243112
123Glucagon signaling pathway_Homo sapiens_hsa049220.08783523
124Galactose metabolism_Homo sapiens_hsa000520.07108161
125AMPK signaling pathway_Homo sapiens_hsa041520.06024555
126Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.03980185
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.00954968
128Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533-0.1384427
129Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1325341
130Hepatitis C_Homo sapiens_hsa05160-0.1240254
131Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1203141
132African trypanosomiasis_Homo sapiens_hsa05143-0.1201565
133GABAergic synapse_Homo sapiens_hsa04727-0.1134490
134Glutamatergic synapse_Homo sapiens_hsa04724-0.1125060
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1071020
136Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601-0.1025888
137Axon guidance_Homo sapiens_hsa04360-0.0946575
138Choline metabolism in cancer_Homo sapiens_hsa05231-0.0921280
139Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0830264
140Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0733198
141Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.0698734
142Dorso-ventral axis formation_Homo sapiens_hsa04320-0.0485204
143One carbon pool by folate_Homo sapiens_hsa00670-0.0454488
144Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0348180
145Sphingolipid metabolism_Homo sapiens_hsa00600-0.0294197
146Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524-0.0283133
147Mineral absorption_Homo sapiens_hsa04978-0.0159967
148Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0018211

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