MFSD3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)8.65376362
2proline metabolic process (GO:0006560)8.62140640
3transcription from mitochondrial promoter (GO:0006390)8.11801625
4replication fork processing (GO:0031297)6.85439648
5embryonic process involved in female pregnancy (GO:0060136)6.47215854
6positive regulation of protein homooligomerization (GO:0032464)6.29882447
7oxidative demethylation (GO:0070989)6.07930279
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.72518320
9establishment of protein localization to mitochondrial membrane (GO:0090151)5.54667353
10regulation of protein homooligomerization (GO:0032462)5.44064325
11DNA strand renaturation (GO:0000733)5.26535923
12viral mRNA export from host cell nucleus (GO:0046784)5.11059877
13mitochondrial DNA metabolic process (GO:0032042)5.05698881
14regulation of integrin activation (GO:0033623)5.05172682
15establishment of apical/basal cell polarity (GO:0035089)4.88479131
16poly(A)+ mRNA export from nucleus (GO:0016973)4.82378484
17glutamine family amino acid biosynthetic process (GO:0009084)4.78091623
18somatic diversification of immune receptors via somatic mutation (GO:0002566)4.65110988
19somatic hypermutation of immunoglobulin genes (GO:0016446)4.65110988
20pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.62239021
21negative regulation of fatty acid biosynthetic process (GO:0045717)4.49527709
22protein retention in ER lumen (GO:0006621)4.49453381
23telomere maintenance via semi-conservative replication (GO:0032201)4.45762081
24L-serine metabolic process (GO:0006563)4.26008856
25formation of translation preinitiation complex (GO:0001731)4.19039464
26negative regulation of JAK-STAT cascade (GO:0046426)4.17935796
27establishment or maintenance of monopolar cell polarity (GO:0061339)4.16202683
28establishment of monopolar cell polarity (GO:0061162)4.16202683
29cellular response to ATP (GO:0071318)4.12119154
30positive regulation of developmental pigmentation (GO:0048087)4.09136400
31sulfur amino acid catabolic process (GO:0000098)4.08347111
32negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.08247277
33nucleotide-excision repair, DNA gap filling (GO:0006297)4.06072695
34negative regulation of cell cycle arrest (GO:0071157)4.03975667
35GDP-mannose metabolic process (GO:0019673)4.03682120
36ribosomal small subunit biogenesis (GO:0042274)4.00711767
37maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.99286101
38base-excision repair, AP site formation (GO:0006285)3.96997278
39peptidyl-arginine omega-N-methylation (GO:0035247)3.95785081
40base-excision repair (GO:0006284)3.94804562
41mitochondrial RNA metabolic process (GO:0000959)3.89859131
42cullin deneddylation (GO:0010388)3.89835788
43mitotic G1 DNA damage checkpoint (GO:0031571)3.87999873
44DNA integration (GO:0015074)3.78316792
45adenine nucleotide transport (GO:0051503)3.76940149
46nuclear envelope reassembly (GO:0031468)3.76235458
47mitotic nuclear envelope reassembly (GO:0007084)3.76235458
48deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.75840777
49regulation of mammary gland epithelial cell proliferation (GO:0033599)3.72419383
50negative regulation of protein oligomerization (GO:0032460)3.72266929
51DNA ligation (GO:0006266)3.71577524
52double-strand break repair via nonhomologous end joining (GO:0006303)3.70486366
53non-recombinational repair (GO:0000726)3.70486366
54heme transport (GO:0015886)3.69610157
55pyrimidine nucleotide catabolic process (GO:0006244)3.69059196
56mRNA cleavage (GO:0006379)3.68488689
57positive regulation of DNA repair (GO:0045739)3.65341097
58protein insertion into membrane (GO:0051205)3.63467194
59regulation of translational fidelity (GO:0006450)3.61616315
60heme biosynthetic process (GO:0006783)3.59256551
61DNA strand elongation involved in DNA replication (GO:0006271)3.54146218
62telomere maintenance via recombination (GO:0000722)3.53870978
63protein deneddylation (GO:0000338)3.53309161
64mitotic G1/S transition checkpoint (GO:0044819)3.52460152
65positive regulation by host of viral transcription (GO:0043923)3.51760121
66folic acid metabolic process (GO:0046655)3.50311501
67protein maturation by protein folding (GO:0022417)3.49235385
68histone arginine methylation (GO:0034969)3.48742621
69G1 DNA damage checkpoint (GO:0044783)3.48106598
70positive regulation of protein oligomerization (GO:0032461)3.46480923
71UV protection (GO:0009650)3.45413489
72alkaloid metabolic process (GO:0009820)3.41378971
73DNA strand elongation (GO:0022616)3.40920306
74negative regulation of response to food (GO:0032096)3.40544031
75negative regulation of appetite (GO:0032099)3.40544031
76embryonic placenta development (GO:0001892)3.40209385
77cellular response to zinc ion (GO:0071294)3.37390791
78protein carboxylation (GO:0018214)3.37165689
79peptidyl-glutamic acid carboxylation (GO:0017187)3.37165689
80purine ribonucleotide transport (GO:0015868)3.35143885
81rRNA transcription (GO:0009303)3.34868641
82protein neddylation (GO:0045116)3.33118476
83regulation of protein oligomerization (GO:0032459)3.30930023
84pentose metabolic process (GO:0019321)3.30262968
85labyrinthine layer development (GO:0060711)3.28393859
86DNA double-strand break processing (GO:0000729)3.26039458
87deoxyribonucleotide catabolic process (GO:0009264)3.24933988
88very-low-density lipoprotein particle assembly (GO:0034379)3.23638308
89regulation of mitochondrial translation (GO:0070129)3.23191554
90purine nucleotide transport (GO:0015865)3.21139069
91rRNA modification (GO:0000154)3.19932945
92guanosine-containing compound biosynthetic process (GO:1901070)3.19910173
93peptidyl-arginine N-methylation (GO:0035246)3.19744917
94peptidyl-arginine methylation (GO:0018216)3.19744917
95nucleoside transmembrane transport (GO:1901642)3.19424989
96single strand break repair (GO:0000012)3.18073722
97regulation of cholesterol biosynthetic process (GO:0045540)3.16132525
98convergent extension (GO:0060026)3.15242968
99termination of RNA polymerase II transcription (GO:0006369)3.14846569
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.14301126
101kinetochore assembly (GO:0051382)3.13296290
102maturation of 5.8S rRNA (GO:0000460)3.12413520
103spliceosomal tri-snRNP complex assembly (GO:0000244)3.11504672
104pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.09993798
105gluconeogenesis (GO:0006094)3.08773077
106metallo-sulfur cluster assembly (GO:0031163)3.07653094
107iron-sulfur cluster assembly (GO:0016226)3.07653094
108pseudouridine synthesis (GO:0001522)3.07609103
109mitochondrial DNA replication (GO:0006264)3.07451787
110glial cell migration (GO:0008347)3.07134100
111monosaccharide biosynthetic process (GO:0046364)3.07111346
112nucleotide-sugar biosynthetic process (GO:0009226)3.06601534
113UTP biosynthetic process (GO:0006228)3.05422713
114hexose biosynthetic process (GO:0019319)3.04461415
115negative regulation of cell aging (GO:0090344)3.01091323
116deoxyribose phosphate catabolic process (GO:0046386)3.00705504
117adenosine receptor signaling pathway (GO:0001973)3.00567935
118negative regulation of Ras GTPase activity (GO:0034261)3.00014026
119planar cell polarity pathway involved in neural tube closure (GO:0090179)2.99235298
120pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.98000601
121glycerol ether metabolic process (GO:0006662)2.96878696
122negative regulation of heart rate (GO:0010459)2.95676730
123oxidative phosphorylation (GO:0006119)2.95337535
124DNA topological change (GO:0006265)2.95206742
125telomere maintenance via telomere lengthening (GO:0010833)2.94253026
126heme metabolic process (GO:0042168)2.94067786
127meiotic chromosome segregation (GO:0045132)2.93830774
128serine family amino acid biosynthetic process (GO:0009070)2.93431539
129regulation of double-strand break repair via homologous recombination (GO:0010569)2.92435147
130negative regulation of tumor necrosis factor production (GO:0032720)2.91654081
131negative regulation of mRNA processing (GO:0050686)2.90617682
132DNA replication checkpoint (GO:0000076)2.89218541
133glutathione biosynthetic process (GO:0006750)2.88046839
134pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.87461837
135amyloid precursor protein catabolic process (GO:0042987)2.87404296
136response to misfolded protein (GO:0051788)2.87204409
137regulation of mitochondrial depolarization (GO:0051900)2.86499676
138regulation of cholesterol metabolic process (GO:0090181)2.85462269
139viral transcription (GO:0019083)2.85169322
140rRNA methylation (GO:0031167)2.84138835
141mitotic recombination (GO:0006312)2.82068802
142L-phenylalanine metabolic process (GO:0006558)2.81901528
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.81901528
144mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.80847122
145pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.80492072
146negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.79576074
147ether metabolic process (GO:0018904)2.77718322
148nucleoside transport (GO:0015858)2.77478303
149anatomical structure regression (GO:0060033)2.76637812
150pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75181115
151urea cycle (GO:0000050)2.74381123
152peptidyl-histidine modification (GO:0018202)2.74070766
153UTP metabolic process (GO:0046051)2.73923260
154CTP biosynthetic process (GO:0006241)2.73650551
155CTP metabolic process (GO:0046036)2.73650551
156NADH metabolic process (GO:0006734)2.72519025
157GTP biosynthetic process (GO:0006183)2.71545319
158pentose-phosphate shunt (GO:0006098)2.62909629
159glucose catabolic process (GO:0006007)2.60983832
160tRNA modification (GO:0006400)2.60288068
161translational termination (GO:0006415)2.59511734
162negative regulation of cell size (GO:0045792)2.56203429
163mitochondrial fusion (GO:0008053)2.55896957
164urea metabolic process (GO:0019627)2.54756156
165translational elongation (GO:0006414)2.53912144
166apoptotic process involved in morphogenesis (GO:0060561)2.53492535
167regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.53194675
168ribonucleoside bisphosphate biosynthetic process (GO:0034030)2.52727532
169nucleoside bisphosphate biosynthetic process (GO:0033866)2.52727532
170purine nucleoside bisphosphate biosynthetic process (GO:0034033)2.52727532
171purine deoxyribonucleotide catabolic process (GO:0009155)2.50832914
172ribonucleoprotein complex biogenesis (GO:0022613)2.50042193
173nucleobase-containing small molecule interconversion (GO:0015949)2.47537584
174establishment of protein localization to mitochondrion (GO:0072655)2.44411437
175protein targeting to mitochondrion (GO:0006626)2.44173990
176regulation of synapse structural plasticity (GO:0051823)2.44086714
177misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.42433380
178coenzyme A biosynthetic process (GO:0015937)2.41902463
179mannose metabolic process (GO:0006013)2.41723497
180proline biosynthetic process (GO:0006561)10.7562023

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse3.38244624
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14037606
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.09524265
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.87919311
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.76662883
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.71358032
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.36049693
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.34301227
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.31440862
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.31440862
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.31440862
12* VDR_21846776_ChIP-Seq_THP-1_Human2.25834986
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.24147796
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.20671954
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.14131100
16* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.12787375
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.12011312
18P68_20966046_ChIP-Seq_HELA_Human2.08801313
19THAP11_20581084_ChIP-Seq_MESCs_Mouse2.06994588
20PU.1_20513432_ChIP-Seq_Bcells_Mouse2.03910521
21KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.00168953
22E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99551801
23RARG_19884340_ChIP-ChIP_MEFs_Mouse1.96873273
24CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96055954
25YY1_21170310_ChIP-Seq_MESCs_Mouse1.93862264
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.89903412
27SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.89583041
28CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.89142898
29* LXR_22292898_ChIP-Seq_THP-1_Human1.84488910
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.83853869
31CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83256031
32E2F7_22180533_ChIP-Seq_HELA_Human1.82739451
33POU5F1_16518401_ChIP-PET_MESCs_Mouse1.82468288
34ZNF263_19887448_ChIP-Seq_K562_Human1.82094428
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.80604468
36DCP1A_22483619_ChIP-Seq_HELA_Human1.79591202
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75783670
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75645272
39RXR_22158963_ChIP-Seq_LIVER_Mouse1.73709392
40NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.73509216
41SRY_22984422_ChIP-ChIP_TESTIS_Rat1.71901929
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.70060188
43EST1_17652178_ChIP-ChIP_JURKAT_Human1.69900407
44* MYC_22102868_ChIP-Seq_BL_Human1.69673827
45TET1_21451524_ChIP-Seq_MESCs_Mouse1.69233111
46KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.68451235
47ELK3_25401928_ChIP-Seq_HUVEC_Human1.63707656
48PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.62246606
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.61256597
50BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.60517811
51SA1_27219007_Chip-Seq_ERYTHROID_Human1.60057412
52ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.57871330
53GABP_19822575_ChIP-Seq_HepG2_Human1.57803569
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57593257
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.57343414
56FOXP1_21924763_ChIP-Seq_HESCs_Human1.56589498
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.55706642
58NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.53986579
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.53822657
60E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52753629
61* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51771334
62CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.51300850
63* ERG_21242973_ChIP-ChIP_JURKAT_Human1.49713776
64* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.49312481
65CTCF_27219007_Chip-Seq_Bcells_Human1.48385605
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.48237200
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.46844397
68SMC4_20622854_ChIP-Seq_HELA_Human1.45875150
69BCL6_27268052_Chip-Seq_Bcells_Human1.45761215
70RXRA_24833708_ChIP-Seq_LIVER_Mouse1.45452567
71TCF3_18692474_ChIP-Seq_MEFs_Mouse1.44425097
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.43290436
73XRN2_22483619_ChIP-Seq_HELA_Human1.42866235
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.42627780
75* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42495051
76ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42425930
77* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42294748
78MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42288121
79NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41959542
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.40499547
81KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40007793
82THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38508797
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.38401937
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.36137112
85* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.34946020
86MAF_26560356_Chip-Seq_TH2_Human1.34910652
87E2F1_20622854_ChIP-Seq_HELA_Human1.34809167
88PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34646368
89CREB1_26743006_Chip-Seq_LNCaP_Human1.34404848
90UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.33540652
91STAT1_20625510_ChIP-Seq_HELA_Human1.32586713
92ETS1_21867929_ChIP-Seq_TH2_Mouse1.32374856
93CTCF_21964334_Chip-Seq_Bcells_Human1.32307058
94KDM2B_26808549_Chip-Seq_DND41_Human1.31276472
95* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.30978665
96* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29520394
97ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.29148478
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29044777
99NANOG_21062744_ChIP-ChIP_HESCs_Human1.28981079
100* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.28008900
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.26427533
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26336260
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26190734
104* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.25992405
105ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25724335
106RARB_24833708_ChIP-Seq_LIVER_Mouse1.25357991
107SOX2_18692474_ChIP-Seq_MEFs_Mouse1.24682448
108* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24545907
109CTCF_21964334_ChIP-Seq_BJAB-B_Human1.24381658
110NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24202978
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23197944
112MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23115479
113GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22957306
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.22876732
115ESR1_15608294_ChIP-ChIP_MCF-7_Human1.22490417
116SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.21968853
117* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.21215629
118CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21123277
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21061653
120* CTCF_26484167_Chip-Seq_Bcells_Mouse1.20744163
121OCT4_18692474_ChIP-Seq_MEFs_Mouse1.20413150
122RACK7_27058665_Chip-Seq_MCF-7_Human1.19904119
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.19696062
124SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19067854
125* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18515049
126* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16972330
127CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14575118
128RARA_24833708_ChIP-Seq_LIVER_Mouse1.14138729
129* TTF2_22483619_ChIP-Seq_HELA_Human1.13413307
130KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12972362
131ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12889607
132BCOR_27268052_Chip-Seq_Bcells_Human1.12615949
133ZFP281_18757296_ChIP-ChIP_E14_Mouse1.12261079
134CREB1_15753290_ChIP-ChIP_HEK293T_Human1.11381253
135MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11233852
136* VDR_23849224_ChIP-Seq_CD4+_Human1.11143503
137YY1_22570637_ChIP-Seq_MALME-3M_Human1.11133600
138* ATF3_27146783_Chip-Seq_COLON_Human1.10831736
139KDM5A_27292631_Chip-Seq_BREAST_Human1.09994713
140SA1_27219007_Chip-Seq_Bcells_Human1.09542909
141SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09168513
142PHF8_20622854_ChIP-Seq_HELA_Human1.08523463
143KDM2B_26808549_Chip-Seq_K562_Human1.08480958
144DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08142373
145IRF1_19129219_ChIP-ChIP_H3396_Human1.07977376
146PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.07896333
147CTCF_20526341_ChIP-Seq_ESCs_Human1.07345844
148HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.06710607
149SPI1_26923725_Chip-Seq_HPCs_Mouse1.06561071

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.46381813
2MP0005171_absent_coat_pigmentation5.50876456
3MP0003806_abnormal_nucleotide_metabolis3.28895858
4MP0009278_abnormal_bone_marrow3.25646654
5MP0010030_abnormal_orbit_morphology3.01410622
6MP0004233_abnormal_muscle_weight2.93386147
7MP0005085_abnormal_gallbladder_physiolo2.87066563
8MP0005451_abnormal_body_composition2.83665171
9MP0001661_extended_life_span2.64042888
10MP0005423_abnormal_somatic_nervous2.60170475
11MP0003705_abnormal_hypodermis_morpholog2.53356661
12MP0004858_abnormal_nervous_system2.48537423
13MP0005075_abnormal_melanosome_morpholog2.46193874
14MP0005365_abnormal_bile_salt2.43744768
15MP0000678_abnormal_parathyroid_gland2.43360446
16MP0008995_early_reproductive_senescence2.41616312
17MP0001188_hyperpigmentation2.38704978
18MP0000751_myopathy2.34240309
19MP0005083_abnormal_biliary_tract2.31785562
20MP0006072_abnormal_retinal_apoptosis2.23131007
21MP0010094_abnormal_chromosome_stability2.16883372
22MP0005174_abnormal_tail_pigmentation2.14477696
23MP0003656_abnormal_erythrocyte_physiolo2.12846057
24MP0004957_abnormal_blastocyst_morpholog2.06619499
25MP0002009_preneoplasia2.03135223
26MP0003786_premature_aging2.02065528
27MP0001545_abnormal_hematopoietic_system1.99756341
28MP0005397_hematopoietic_system_phenotyp1.99756341
29MP0004133_heterotaxia1.95722684
30MP0005058_abnormal_lysosome_morphology1.93065227
31MP0003123_paternal_imprinting1.92513688
32MP0000003_abnormal_adipose_tissue1.87593201
33MP0004142_abnormal_muscle_tone1.87447361
34MP0001986_abnormal_taste_sensitivity1.77016341
35MP0000750_abnormal_muscle_regeneration1.75714444
36MP0008932_abnormal_embryonic_tissue1.73229313
37MP0005409_darkened_coat_color1.72293108
38MP0008058_abnormal_DNA_repair1.71957538
39MP0002254_reproductive_system_inflammat1.71185097
40MP0005076_abnormal_cell_differentiation1.70267004
41MP0000537_abnormal_urethra_morphology1.53845725
42MP0000639_abnormal_adrenal_gland1.52764183
43MP0010234_abnormal_vibrissa_follicle1.52557687
44MP0001346_abnormal_lacrimal_gland1.50853419
45MP0000462_abnormal_digestive_system1.47713019
46MP0009840_abnormal_foam_cell1.47219500
47MP0003890_abnormal_embryonic-extraembry1.47143713
48MP0002249_abnormal_larynx_morphology1.44505179
49MP0003283_abnormal_digestive_organ1.43495098
50MP0000538_abnormal_urinary_bladder1.43316340
51MP0003453_abnormal_keratinocyte_physiol1.42291512
52MP0003172_abnormal_lysosome_physiology1.40394519
53MP0001502_abnormal_circadian_rhythm1.38539030
54MP0005266_abnormal_metabolism1.38309448
55MP0003136_yellow_coat_color1.37359236
56MP0002269_muscular_atrophy1.37342422
57MP0005360_urolithiasis1.36514896
58MP0001968_abnormal_touch/_nociception1.36233190
59MP0001849_ear_inflammation1.36206649
60MP0003119_abnormal_digestive_system1.36084697
61MP0000579_abnormal_nail_morphology1.34189546
62MP0000015_abnormal_ear_pigmentation1.32594242
63MP0003718_maternal_effect1.29402560
64MP0002282_abnormal_trachea_morphology1.27477278
65MP0000747_muscle_weakness1.27371055
66MP0002139_abnormal_hepatobiliary_system1.26878370
67MP0002736_abnormal_nociception_after1.24701928
68MP0000470_abnormal_stomach_morphology1.21051036
69MP0008877_abnormal_DNA_methylation1.20358856
70MP0000013_abnormal_adipose_tissue1.19098770
71MP0002089_abnormal_postnatal_growth/wei1.18442694
72MP0000358_abnormal_cell_content/1.18396523
73MP0005375_adipose_tissue_phenotype1.18232900
74MP0000490_abnormal_crypts_of1.18137253
75MP0006035_abnormal_mitochondrial_morpho1.17430881
76MP0005666_abnormal_adipose_tissue1.17057269
77MP0003111_abnormal_nucleus_morphology1.16045576
78MP0006082_CNS_inflammation1.15751430
79MP0001293_anophthalmia1.15049099
80MP0002160_abnormal_reproductive_system1.13850171
81MP0001756_abnormal_urination1.12906759
82MP0000685_abnormal_immune_system1.11096095
83MP0008260_abnormal_autophagy1.10750328
84MP0001764_abnormal_homeostasis1.08311011
85MP0004147_increased_porphyrin_level1.07030916
86MP0006036_abnormal_mitochondrial_physio1.06712418
87MP0001697_abnormal_embryo_size1.06540207
88MP0002234_abnormal_pharynx_morphology1.06521780
89MP0001324_abnormal_eye_pigmentation1.05102777
90MP0002086_abnormal_extraembryonic_tissu1.04677941
91MP0002653_abnormal_ependyma_morphology1.03225228
92MP0001348_abnormal_lacrimal_gland1.02355064
93MP0002822_catalepsy1.01824847
94MP0003693_abnormal_embryo_hatching1.01344091
95MP0003137_abnormal_impulse_conducting0.99478890
96MP0005332_abnormal_amino_acid0.98954034
97MP0000049_abnormal_middle_ear0.98868377
98MP0002796_impaired_skin_barrier0.98394096
99MP0009333_abnormal_splenocyte_physiolog0.96242906
100MP0005330_cardiomyopathy0.95900252
101MP0009672_abnormal_birth_weight0.94719271
102MP0005376_homeostasis/metabolism_phenot0.94640363
103MP0000467_abnormal_esophagus_morphology0.94638715
104MP0001340_abnormal_eyelid_morphology0.94180607
105MP0008875_abnormal_xenobiotic_pharmacok0.93605372
106MP0000371_diluted_coat_color0.93467836
107MP0004019_abnormal_vitamin_homeostasis0.92228359
108MP0001727_abnormal_embryo_implantation0.91414302
109MP0003828_pulmonary_edema0.91309807
110MP0003329_amyloid_beta_deposits0.91231633
111MP0002060_abnormal_skin_morphology0.88482131
112MP0005377_hearing/vestibular/ear_phenot0.87264476
113MP0003878_abnormal_ear_physiology0.87264476
114MP0002085_abnormal_embryonic_tissue0.87127615
115MP0005253_abnormal_eye_physiology0.87004433
116MP0000762_abnormal_tongue_morphology0.84338006
117MP0002019_abnormal_tumor_incidence0.84144551
118MP0005584_abnormal_enzyme/coenzyme_acti0.83924432
119MP0004381_abnormal_hair_follicle0.83565944
120MP0010771_integument_phenotype0.83330461
121MP0002111_abnormal_tail_morphology0.83314882
122MP0002084_abnormal_developmental_patter0.82436602
123MP0002932_abnormal_joint_morphology0.81114602
124MP0003077_abnormal_cell_cycle0.80971232
125MP0001529_abnormal_vocalization0.80382756
126MP0003186_abnormal_redox_activity0.80015019
127MP0005645_abnormal_hypothalamus_physiol0.78755580
128MP0002132_abnormal_respiratory_system0.77751016
129MP0004197_abnormal_fetal_growth/weight/0.77613582
130MP0009115_abnormal_fat_cell0.76870009
131MP0003315_abnormal_perineum_morphology0.76296769
132MP0002405_respiratory_system_inflammati0.75866689
133MP0009931_abnormal_skin_appearance0.75167801
134MP0005501_abnormal_skin_physiology0.74210577
135MP0000313_abnormal_cell_death0.73680762
136MP0000350_abnormal_cell_proliferation0.73320225
137MP0004130_abnormal_muscle_cell0.73318593
138MP0000759_abnormal_skeletal_muscle0.73282477
139MP0003567_abnormal_fetal_cardiomyocyte0.73041592
140MP0002075_abnormal_coat/hair_pigmentati0.72900713
141MP0001664_abnormal_digestion0.72478193
142MP0004134_abnormal_chest_morphology0.72164935
143MP0009384_cardiac_valve_regurgitation0.72148083
144MP0003638_abnormal_response/metabolism_0.71998802
145MP0001873_stomach_inflammation0.69930228
146MP0002114_abnormal_axial_skeleton0.69447301
147MP0000566_synostosis0.68425940
148MP0002970_abnormal_white_adipose0.68393408
149MP0009053_abnormal_anal_canal0.68166646
150MP0001919_abnormal_reproductive_system0.68101673
151MP0003942_abnormal_urinary_system0.67616150
152MP0001881_abnormal_mammary_gland0.67301030
153MP0001672_abnormal_embryogenesis/_devel0.66932194
154MP0005380_embryogenesis_phenotype0.66932194
155MP0003984_embryonic_growth_retardation0.65599456
156MP0000681_abnormal_thyroid_gland0.65319592
157MP0001186_pigmentation_phenotype0.64855801
158MP0001730_embryonic_growth_arrest0.64585554
159MP0002080_prenatal_lethality0.63530465
160MP0002971_abnormal_brown_adipose0.63246629
161MP0002332_abnormal_exercise_endurance0.63172790
162MP0000689_abnormal_spleen_morphology0.62311291
163MP0004185_abnormal_adipocyte_glucose0.61972312

Predicted human phenotypes

RankGene SetZ-score
1Testicular atrophy (HP:0000029)5.58234541
2Pustule (HP:0200039)4.97890858
3Concave nail (HP:0001598)4.89452463
4Rectal fistula (HP:0100590)4.73265848
5Rectovaginal fistula (HP:0000143)4.73265848
6Rib fusion (HP:0000902)4.56805631
7Hypochromic microcytic anemia (HP:0004840)4.53035269
8Facial hemangioma (HP:0000329)4.44692380
9Increased IgM level (HP:0003496)4.43451789
10Poikiloderma (HP:0001029)4.31987028
11Vaginal fistula (HP:0004320)4.26095005
12Tongue fasciculations (HP:0001308)4.25936052
13Abnormal hemoglobin (HP:0011902)4.17907965
14Annular pancreas (HP:0001734)4.06563044
15Turricephaly (HP:0000262)4.05290577
16Intestinal fistula (HP:0100819)4.02526130
17Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.93982173
18Alopecia of scalp (HP:0002293)3.93390156
19Muscle fibrillation (HP:0010546)3.81623702
20Coronal craniosynostosis (HP:0004440)3.79695727
21Ulnar bowing (HP:0003031)3.47568775
22Hypokinesia (HP:0002375)3.43141515
23Increased muscle lipid content (HP:0009058)3.34584494
24Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.30043382
25Ragged-red muscle fibers (HP:0003200)3.24870984
26Thin bony cortex (HP:0002753)3.21914090
27Increased intramyocellular lipid droplets (HP:0012240)3.18580723
28Diaphragmatic weakness (HP:0009113)3.16862002
29Premature skin wrinkling (HP:0100678)3.14997758
30Exertional dyspnea (HP:0002875)3.13091551
31Mucopolysacchariduria (HP:0008155)3.09284688
32Urinary glycosaminoglycan excretion (HP:0003541)3.09284688
33Anteriorly placed anus (HP:0001545)3.08347361
34Clumsiness (HP:0002312)3.07130716
35Dysostosis multiplex (HP:0000943)3.00825201
36Pancreatic islet-cell hyperplasia (HP:0004510)2.98187129
37Renal Fanconi syndrome (HP:0001994)2.96386757
38Myopathic facies (HP:0002058)2.96247942
39Intestinal atresia (HP:0011100)2.94295937
40Progressive muscle weakness (HP:0003323)2.92811351
41Abnormality of male internal genitalia (HP:0000022)2.92421219
42Joint stiffness (HP:0001387)2.90125921
43Squamous cell carcinoma (HP:0002860)2.89845270
44Amniotic constriction ring (HP:0009775)2.88876445
45Abnormality of placental membranes (HP:0011409)2.88876445
46Alacrima (HP:0000522)2.88831033
47Short humerus (HP:0005792)2.87029444
48Hemorrhage of the eye (HP:0011885)2.86966366
49Aplasia/hypoplasia of the humerus (HP:0006507)2.85591622
50Increased hepatocellular lipid droplets (HP:0006565)2.83493999
51Microvesicular hepatic steatosis (HP:0001414)2.83105713
52Lipid accumulation in hepatocytes (HP:0006561)2.82457101
53Absent radius (HP:0003974)2.81532186
54Premature graying of hair (HP:0002216)2.80571101
55Abnormality of the intrinsic pathway (HP:0010989)2.78288991
56Abnormality of aromatic amino acid family metabolism (HP:0004338)2.76805872
57Abnormality of mucopolysaccharide metabolism (HP:0011020)2.76499851
58Abnormality of polysaccharide metabolism (HP:0011012)2.76499851
59Abnormality of glycosaminoglycan metabolism (HP:0004371)2.76499851
60Redundant skin (HP:0001582)2.76180081
61Large for gestational age (HP:0001520)2.75920677
62Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.74164057
63Vertebral hypoplasia (HP:0008417)2.74164057
64Prolonged partial thromboplastin time (HP:0003645)2.73125709
65Short chin (HP:0000331)2.72237442
66Mesangial abnormality (HP:0001966)2.70025375
67Broad alveolar ridges (HP:0000187)2.68119382
68Hypobetalipoproteinemia (HP:0003563)2.66233060
69Diminished movement (HP:0002374)2.65515066
70Absent forearm bone (HP:0003953)2.61108983
71Aplasia involving forearm bones (HP:0009822)2.61108983
72Neonatal onset (HP:0003623)2.59756825
73Akinesia (HP:0002304)2.59054619
74Breast hypoplasia (HP:0003187)2.58110234
75Orthostatic hypotension (HP:0001278)2.54822607
76Opisthotonus (HP:0002179)2.54146456
77Congenital hip dislocation (HP:0001374)2.53011083
78Albinism (HP:0001022)2.51515421
79Cholelithiasis (HP:0001081)2.50476546
80Delayed epiphyseal ossification (HP:0002663)2.50402366
81Truncus arteriosus (HP:0001660)2.50369984
82Aplasia of the musculature (HP:0100854)2.47627064
83Polycythemia (HP:0001901)2.46942062
84Dysautonomia (HP:0002459)2.46872019
85Congenital malformation of the right heart (HP:0011723)2.44863518
86Double outlet right ventricle (HP:0001719)2.44863518
87Absent thumb (HP:0009777)2.43574966
88Stridor (HP:0010307)2.42380179
89Male infertility (HP:0003251)2.39184048
90Reduced antithrombin III activity (HP:0001976)2.38168835
91Microretrognathia (HP:0000308)2.37553918
92Birth length less than 3rd percentile (HP:0003561)2.35888420
93Hypochromic anemia (HP:0001931)2.35876562
94Type I transferrin isoform profile (HP:0003642)2.33911752
95Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.32486636
96Broad distal phalanx of finger (HP:0009836)2.32183327
97Aplasia/Hypoplasia of the sacrum (HP:0008517)2.28852561
98Capillary hemangiomas (HP:0005306)2.28366697
99Rectal prolapse (HP:0002035)2.24948018
100Cerebral hypomyelination (HP:0006808)2.23927076
101Basal cell carcinoma (HP:0002671)2.21944955
102Abnormal number of erythroid precursors (HP:0012131)2.21461455
103Abnormal gallbladder morphology (HP:0012437)2.19853805
104Intrahepatic cholestasis (HP:0001406)2.19124128
105Lower limb hyperreflexia (HP:0002395)2.19019206
106Decreased lacrimation (HP:0000633)2.15906196
107Pterygium (HP:0001059)2.15217409
108Hypotrichosis (HP:0001006)2.14772811
109Hepatocellular necrosis (HP:0001404)2.14730642
110Bifid uvula (HP:0000193)2.13028176
111Muscle fiber atrophy (HP:0100295)2.11487401
112Dyschromatopsia (HP:0007641)2.09902206
113Poor suck (HP:0002033)2.08972561
114Exercise intolerance (HP:0003546)2.08627980
115Achilles tendon contracture (HP:0001771)2.06839965
116Hypoplastic heart (HP:0001961)2.06767872
117Abnormality of the aortic arch (HP:0012303)2.04889611
118IgA deficiency (HP:0002720)2.03678807
119Growth hormone excess (HP:0000845)2.03374302
120Mitochondrial inheritance (HP:0001427)2.03258010
121Abnormality of cells of the erythroid lineage (HP:0012130)2.03187797
122Type 2 muscle fiber atrophy (HP:0003554)2.02310761
123Bulbar palsy (HP:0001283)2.01698351
124Abnormal epiphyseal ossification (HP:0010656)2.01256545
125Acute hepatic failure (HP:0006554)2.00420708
126Abnormality of the gallbladder (HP:0005264)1.99560916
127Abnormal trabecular bone morphology (HP:0100671)1.99210138
128Atrioventricular block (HP:0001678)1.98677433
129Generalized amyotrophy (HP:0003700)1.97286353
130Hamartoma (HP:0010566)1.96631857
131Acute encephalopathy (HP:0006846)1.95770810
132Epiphyseal stippling (HP:0010655)1.95704580
133Gastrointestinal dysmotility (HP:0002579)1.95297618
134Selective tooth agenesis (HP:0001592)1.95021634
135Hyperthyroidism (HP:0000836)1.94103405
136Abnormal glycosylation (HP:0012345)1.92571253
137Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.92571253
138Abnormal protein N-linked glycosylation (HP:0012347)1.92571253
139Abnormal protein glycosylation (HP:0012346)1.92571253
140Aplasia/Hypoplasia of the patella (HP:0006498)1.91694967
141Choanal stenosis (HP:0000452)1.89727769
142Acute necrotizing encephalopathy (HP:0006965)1.88970346
143Abnormality of the Achilles tendon (HP:0005109)1.88591267
144Respiratory difficulties (HP:0002880)1.86046859
145Hyperacusis (HP:0010780)1.86002607
146Fetal akinesia sequence (HP:0001989)1.85306954
147Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84689929
148Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84689929
149Asymmetric septal hypertrophy (HP:0001670)1.83676143
150Bowed forearm bones (HP:0003956)1.83410348
151Bowing of the arm (HP:0006488)1.83410348
152Progressive external ophthalmoplegia (HP:0000590)1.83371230
153Hypoplasia of the radius (HP:0002984)1.83081487
154Patellar aplasia (HP:0006443)1.82656757
155Hepatic necrosis (HP:0002605)1.81773886
156Popliteal pterygium (HP:0009756)1.81458932
157Long palpebral fissure (HP:0000637)1.81392012
158Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.80354121
159Abnormal urine phosphate concentration (HP:0012599)1.79008018
160Abnormal mitochondria in muscle tissue (HP:0008316)1.78517679
161Abnormality of the pancreatic islet cells (HP:0006476)1.78285860
162Abnormality of endocrine pancreas physiology (HP:0012093)1.78285860
163Gastrointestinal atresia (HP:0002589)1.77738495
164Lactic acidosis (HP:0003128)1.77346824
165Thin ribs (HP:0000883)1.76365642
166Increased CSF lactate (HP:0002490)1.74463587
167Upper limb amyotrophy (HP:0009129)1.73876338
168Distal upper limb amyotrophy (HP:0007149)1.73876338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.72328554
2MAPK155.59525284
3MAP3K64.84215468
4DDR24.68732859
5TRIB34.43904810
6SMG14.01607568
7MAP3K113.72296865
8VRK23.47692791
9PINK12.98722450
10FGR2.97623676
11PIM22.92657517
12MATK2.87516459
13DAPK12.73588960
14SIK12.62020124
15UHMK12.50937331
16IRAK32.43795388
17TYRO32.34621739
18EPHA22.19905388
19ERN12.13715814
20CSK2.10398356
21EEF2K2.09673170
22PRKD22.01666935
23PRKD32.01218813
24YES11.98653705
25BMX1.91001507
26MUSK1.87018348
27CDK71.65246665
28DYRK1B1.59034171
29PKN21.56333080
30AKT31.50408501
31IRAK21.50166123
32TESK11.44761696
33MST1R1.43547324
34TRPM71.40823346
35TLK11.37280312
36BRAF1.33630211
37BUB11.29420305
38TAF11.27323965
39MAPK111.23137197
40PIM11.21022481
41PDGFRA1.18026077
42ZAK1.15620038
43PDK21.12515801
44TESK21.11152500
45PHKG21.09445990
46PHKG11.09445990
47RPS6KC11.08245922
48RPS6KL11.08245922
49PRPF4B1.03637771
50DYRK31.02302391
51ABL21.01197269
52BCKDK1.00443715
53PDPK11.00073193
54CDK190.98355352
55WNK40.97276770
56GSK3A0.95349986
57CDK60.94879576
58RPS6KA60.94557725
59ILK0.93589035
60PAK40.93187411
61NME20.90604068
62CDC42BPA0.83860332
63RPS6KA20.83716803
64CHEK20.82483314
65PLK10.81325248
66WEE10.77779440
67MET0.77040006
68LATS20.76848191
69MAP3K100.76817259
70CAMK2B0.76366100
71RAF10.76108749
72MAP2K30.73563188
73CSNK1A1L0.72899862
74TTN0.72515052
75CAMK2G0.70227571
76CDK40.69435728
77PTK60.68286510
78MAPKAPK30.67709401
79AKT20.66736216
80PRKCI0.64944321
81LMTK20.64758812
82MAP2K20.63390725
83CSNK1G10.61011676
84CSNK2A10.60435646
85LRRK20.58237847
86PBK0.56511710
87RPS6KA50.56324441
88LYN0.55183449
89NTRK10.51339089
90MAPK40.51161173
91EPHB20.50197026
92MAPKAPK50.48505366
93CSNK1G20.48424741
94CAMK2D0.47992270
95HIPK20.47959176
96TTK0.47827323
97OXSR10.47429931
98DYRK20.46293035
99MAPK120.45450284
100AURKA0.45172094
101CSNK2A20.44358413
102PTK20.44255377
103MAP3K80.43624256
104LIMK10.43621783
105CAMK1D0.43351908
106CAMK2A0.42719810
107RIPK10.41467106
108MAP3K10.41463842
109TNK20.41367669
110STK40.41199327
111BRSK10.41149156
112ATR0.41044975
113MAP2K60.40697965
114CDK80.40057389
115TBK10.39802417
116RPS6KA10.39625797
117STK390.39400686
118AURKB0.38357544
119EGFR0.36577386
120MAPK30.36187093
121PRKAA10.35942310
122BLK0.35521648
123NME10.33444009
124RPS6KB10.33281443
125CDK20.31942690
126CDK11A0.29214386
127MAP4K10.28739069
128RPS6KB20.28534676
129TAOK10.28287373
130LCK0.27252958
131TAOK20.26883856
132CDK150.25992135
133EIF2AK10.25534008
134IKBKB0.25253783
135PAK10.24979999
136CSNK1G30.23898012
137MAPK10.23812171
138PRKCD0.21455030
139CDK180.21125412
140ACVR1B0.20784751
141KDR0.20353096
142STK160.20181276
143INSR0.19904019
144ARAF0.18508754
145MAPK100.18303644
146MTOR0.17702933
147CDK140.17200748
148GRK60.17042774
149DAPK30.17035938
150VRK10.14347212
151PRKD10.13297898
152CDK10.13143718
153CHEK10.12998702
154PRKCZ0.12992209

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.30616447
2Fatty acid biosynthesis_Homo sapiens_hsa000614.07443199
3Base excision repair_Homo sapiens_hsa034104.05838861
4DNA replication_Homo sapiens_hsa030303.68173576
5Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.94039070
6Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.50146811
7Ribosome_Homo sapiens_hsa030102.47059252
8Folate biosynthesis_Homo sapiens_hsa007902.34237679
9Arginine and proline metabolism_Homo sapiens_hsa003302.29373209
10Sulfur relay system_Homo sapiens_hsa041222.23812276
11Fatty acid elongation_Homo sapiens_hsa000622.19323586
12Homologous recombination_Homo sapiens_hsa034402.12586825
13Nucleotide excision repair_Homo sapiens_hsa034202.06386545
14Oxidative phosphorylation_Homo sapiens_hsa001901.98714572
15Steroid biosynthesis_Homo sapiens_hsa001001.96888162
16Biosynthesis of amino acids_Homo sapiens_hsa012301.93395932
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.91254518
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.90889065
19Fatty acid metabolism_Homo sapiens_hsa012121.87576674
202-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.82280557
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79689111
22Spliceosome_Homo sapiens_hsa030401.76162090
23Parkinsons disease_Homo sapiens_hsa050121.70052104
24Vitamin B6 metabolism_Homo sapiens_hsa007501.64465457
25Pentose and glucuronate interconversions_Homo sapiens_hsa000401.59391424
26Proteasome_Homo sapiens_hsa030501.58128756
27Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.57896810
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54546126
29Arginine biosynthesis_Homo sapiens_hsa002201.42949106
30Other glycan degradation_Homo sapiens_hsa005111.42782669
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.38480443
32Phenylalanine metabolism_Homo sapiens_hsa003601.35425655
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.34007055
34Glutathione metabolism_Homo sapiens_hsa004801.27249987
35Primary bile acid biosynthesis_Homo sapiens_hsa001201.26874870
36Fanconi anemia pathway_Homo sapiens_hsa034601.25523569
37RNA transport_Homo sapiens_hsa030131.21916618
38RNA polymerase_Homo sapiens_hsa030201.20455923
39Huntingtons disease_Homo sapiens_hsa050161.18028322
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.17334457
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.14883347
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.08956100
43N-Glycan biosynthesis_Homo sapiens_hsa005101.08621274
44Alzheimers disease_Homo sapiens_hsa050101.00904622
45Circadian rhythm_Homo sapiens_hsa047100.98518252
46Fructose and mannose metabolism_Homo sapiens_hsa000510.98152129
47Central carbon metabolism in cancer_Homo sapiens_hsa052300.97047637
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95639640
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95363862
50Pyruvate metabolism_Homo sapiens_hsa006200.94749820
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90743587
52mRNA surveillance pathway_Homo sapiens_hsa030150.89616831
53One carbon pool by folate_Homo sapiens_hsa006700.89181571
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.88699119
55Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.88196681
56Hedgehog signaling pathway_Homo sapiens_hsa043400.88118323
57Pyrimidine metabolism_Homo sapiens_hsa002400.86822037
58Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.85215535
59Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.84638434
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83946963
61Basal cell carcinoma_Homo sapiens_hsa052170.78999720
62Notch signaling pathway_Homo sapiens_hsa043300.78912450
63Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77172219
64Peroxisome_Homo sapiens_hsa041460.77118316
65p53 signaling pathway_Homo sapiens_hsa041150.75890246
66Sphingolipid metabolism_Homo sapiens_hsa006000.75438929
67Metabolic pathways_Homo sapiens_hsa011000.71767940
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.71765558
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.69967270
70Propanoate metabolism_Homo sapiens_hsa006400.69890206
71Primary immunodeficiency_Homo sapiens_hsa053400.67620314
72Galactose metabolism_Homo sapiens_hsa000520.67384683
73Carbon metabolism_Homo sapiens_hsa012000.67232141
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66637356
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.66479130
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65988614
77Purine metabolism_Homo sapiens_hsa002300.65983150
78Vitamin digestion and absorption_Homo sapiens_hsa049770.64434030
79Hippo signaling pathway_Homo sapiens_hsa043900.64074272
80Histidine metabolism_Homo sapiens_hsa003400.63884026
81Chemical carcinogenesis_Homo sapiens_hsa052040.63509894
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.63470984
83Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62137680
84Cell cycle_Homo sapiens_hsa041100.59011488
85AMPK signaling pathway_Homo sapiens_hsa041520.58321360
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.58299593
87Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.57498011
88Bladder cancer_Homo sapiens_hsa052190.56588367
89TGF-beta signaling pathway_Homo sapiens_hsa043500.53055632
90Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48302514
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.47780389
92Tryptophan metabolism_Homo sapiens_hsa003800.47656717
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47208361
94Lysine degradation_Homo sapiens_hsa003100.46338388
95Pentose phosphate pathway_Homo sapiens_hsa000300.45358093
96Shigellosis_Homo sapiens_hsa051310.45304636
97Fatty acid degradation_Homo sapiens_hsa000710.44287961
98Selenocompound metabolism_Homo sapiens_hsa004500.43738005
99Vibrio cholerae infection_Homo sapiens_hsa051100.43546801
100Fat digestion and absorption_Homo sapiens_hsa049750.42812223
101Cardiac muscle contraction_Homo sapiens_hsa042600.42696918
102Alcoholism_Homo sapiens_hsa050340.42608168
103VEGF signaling pathway_Homo sapiens_hsa043700.41997019
104Lysosome_Homo sapiens_hsa041420.40897867
105Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.40813606
106Retinol metabolism_Homo sapiens_hsa008300.40052614
107Linoleic acid metabolism_Homo sapiens_hsa005910.39874912
108Insulin signaling pathway_Homo sapiens_hsa049100.38651563
109mTOR signaling pathway_Homo sapiens_hsa041500.37695984
110Butanoate metabolism_Homo sapiens_hsa006500.37685448
111beta-Alanine metabolism_Homo sapiens_hsa004100.37048576
112Starch and sucrose metabolism_Homo sapiens_hsa005000.35689644
113Glycerophospholipid metabolism_Homo sapiens_hsa005640.34907724
114Arachidonic acid metabolism_Homo sapiens_hsa005900.34398077
115Protein export_Homo sapiens_hsa030600.33360404
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33033933
117Sulfur metabolism_Homo sapiens_hsa009200.32521441
118Complement and coagulation cascades_Homo sapiens_hsa046100.31375027
119Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.30963883
120Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29778062
121Prion diseases_Homo sapiens_hsa050200.29699704
122Endometrial cancer_Homo sapiens_hsa052130.28311733
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.27550319
124Thyroid cancer_Homo sapiens_hsa052160.27505991
125Glucagon signaling pathway_Homo sapiens_hsa049220.27302991
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.26804688
127ABC transporters_Homo sapiens_hsa020100.26477307
128Tyrosine metabolism_Homo sapiens_hsa003500.25896136
129Wnt signaling pathway_Homo sapiens_hsa043100.25442885
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.24879087
131Basal transcription factors_Homo sapiens_hsa030220.23236746

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