

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuronal action potential propagation (GO:0019227) | 4.41174664 |
| 2 | L-amino acid import (GO:0043092) | 4.35650880 |
| 3 | neurotransmitter transport (GO:0006836) | 4.11544667 |
| 4 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 3.98311214 |
| 5 | response to mercury ion (GO:0046689) | 3.90633292 |
| 6 | regulation of neurotransmitter levels (GO:0001505) | 3.87168625 |
| 7 | dendritic spine morphogenesis (GO:0060997) | 3.78431538 |
| 8 | cellular potassium ion homeostasis (GO:0030007) | 3.73211369 |
| 9 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.72607787 |
| 10 | regulation of voltage-gated calcium channel activity (GO:1901385) | 3.70656692 |
| 11 | axon ensheathment in central nervous system (GO:0032291) | 3.63869500 |
| 12 | central nervous system myelination (GO:0022010) | 3.63869500 |
| 13 | vocalization behavior (GO:0071625) | 3.60992317 |
| 14 | negative regulation of cell killing (GO:0031342) | 3.54806230 |
| 15 | negative regulation of leukocyte mediated cytotoxicity (GO:0001911) | 3.54806230 |
| 16 | metanephric nephron tubule development (GO:0072234) | 3.52724945 |
| 17 | metanephric tubule development (GO:0072170) | 3.52724945 |
| 18 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 3.51405735 |
| 19 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.45123311 |
| 20 | amino acid import (GO:0043090) | 3.43620739 |
| 21 | excretion (GO:0007588) | 3.42871061 |
| 22 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 3.41841143 |
| 23 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.40749736 |
| 24 | serotonin metabolic process (GO:0042428) | 3.36835847 |
| 25 | synaptic vesicle exocytosis (GO:0016079) | 3.36213559 |
| 26 | proline transport (GO:0015824) | 3.35672994 |
| 27 | regulation of neurotransmitter transport (GO:0051588) | 3.35635220 |
| 28 | regulation of vesicle fusion (GO:0031338) | 3.35601516 |
| 29 | regulation of synapse structural plasticity (GO:0051823) | 3.34865674 |
| 30 | positive regulation of dendritic spine development (GO:0060999) | 3.29641007 |
| 31 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.28509489 |
| 32 | glutamate receptor signaling pathway (GO:0007215) | 3.27882717 |
| 33 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.26227928 |
| 34 | cerebellar granule cell differentiation (GO:0021707) | 3.25337604 |
| 35 | glutamate secretion (GO:0014047) | 3.23251760 |
| 36 | postsynaptic membrane organization (GO:0001941) | 3.21954970 |
| 37 | primary amino compound metabolic process (GO:1901160) | 3.21791306 |
| 38 | synaptic transmission (GO:0007268) | 3.17799816 |
| 39 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.16392536 |
| 40 | response to pheromone (GO:0019236) | 3.15549261 |
| 41 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 3.14060911 |
| 42 | auditory behavior (GO:0031223) | 3.10786760 |
| 43 | metanephric nephron epithelium development (GO:0072243) | 3.10510278 |
| 44 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 3.08505827 |
| 45 | synaptic transmission, glutamatergic (GO:0035249) | 3.06904271 |
| 46 | response to parathyroid hormone (GO:0071107) | 3.02866217 |
| 47 | neurofilament cytoskeleton organization (GO:0060052) | 3.01126658 |
| 48 | regulation of exocytosis (GO:0017157) | 3.01067211 |
| 49 | positive regulation of neurotransmitter transport (GO:0051590) | 2.97471761 |
| 50 | sodium ion export (GO:0071436) | 2.96789301 |
| 51 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 2.96751427 |
| 52 | protein localization to synapse (GO:0035418) | 2.92800880 |
| 53 | neurotransmitter-gated ion channel clustering (GO:0072578) | 2.91533573 |
| 54 | transmission of nerve impulse (GO:0019226) | 2.91098762 |
| 55 | acidic amino acid transport (GO:0015800) | 2.90131814 |
| 56 | detection of calcium ion (GO:0005513) | 2.88617438 |
| 57 | membrane repolarization (GO:0086009) | 2.88256743 |
| 58 | neurotransmitter uptake (GO:0001504) | 2.87744094 |
| 59 | regulation of sodium ion transmembrane transporter activity (GO:2000649) | 2.87605577 |
| 60 | sodium ion homeostasis (GO:0055078) | 2.87103200 |
| 61 | neuron-neuron synaptic transmission (GO:0007270) | 2.86831505 |
| 62 | signal release (GO:0023061) | 2.85568296 |
| 63 | neuromuscular synaptic transmission (GO:0007274) | 2.83431554 |
| 64 | metanephric epithelium development (GO:0072207) | 2.83216645 |
| 65 | neuromuscular process controlling posture (GO:0050884) | 2.82391397 |
| 66 | vesicle docking involved in exocytosis (GO:0006904) | 2.82343401 |
| 67 | long-term synaptic potentiation (GO:0060291) | 2.81361350 |
| 68 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 2.79330040 |
| 69 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 2.69295817 |
| 70 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.68971316 |
| 71 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.61074143 |
| 72 | response to histamine (GO:0034776) | 2.60112786 |
| 73 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.59370752 |
| 74 | signal complex assembly (GO:0007172) | 2.58044924 |
| 75 | potassium ion import (GO:0010107) | 2.57824827 |
| 76 | long-term memory (GO:0007616) | 2.55513057 |
| 77 | cellular response to interleukin-15 (GO:0071350) | 2.54113598 |
| 78 | locomotory exploration behavior (GO:0035641) | 2.53834728 |
| 79 | positive regulation of synapse maturation (GO:0090129) | 2.49961716 |
| 80 | response to interleukin-15 (GO:0070672) | 2.48188192 |
| 81 | regulation of postsynaptic membrane potential (GO:0060078) | 2.47121958 |
| 82 | positive regulation of gamma-delta T cell activation (GO:0046645) | 2.44713990 |
| 83 | retrograde transport, vesicle recycling within Golgi (GO:0000301) | 2.42907820 |
| 84 | exploration behavior (GO:0035640) | 2.41747000 |
| 85 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.41080209 |
| 86 | regulation of synaptic vesicle transport (GO:1902803) | 2.40528631 |
| 87 | cellular sodium ion homeostasis (GO:0006883) | 2.39353941 |
| 88 | cAMP catabolic process (GO:0006198) | 2.38927709 |
| 89 | synaptic vesicle endocytosis (GO:0048488) | 2.38345982 |
| 90 | relaxation of cardiac muscle (GO:0055119) | 2.38125822 |
| 91 | synaptic vesicle maturation (GO:0016188) | 2.36477971 |
| 92 | positive regulation of CREB transcription factor activity (GO:0032793) | 2.36333542 |
| 93 | activation of protein kinase A activity (GO:0034199) | 2.36139055 |
| 94 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.36109444 |
| 95 | glycosphingolipid biosynthetic process (GO:0006688) | 2.34851281 |
| 96 | protein targeting to Golgi (GO:0000042) | 2.32635482 |
| 97 | regulation of synaptic plasticity (GO:0048167) | 2.31325343 |
| 98 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.30497559 |
| 99 | cell communication by electrical coupling (GO:0010644) | 2.29920188 |
| 100 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.29126281 |
| 101 | long term synaptic depression (GO:0060292) | 2.28948445 |
| 102 | positive T cell selection (GO:0043368) | 2.28842679 |
| 103 | phospholipid scrambling (GO:0017121) | 2.27969300 |
| 104 | regulation of dendritic spine morphogenesis (GO:0061001) | 2.27791860 |
| 105 | sialylation (GO:0097503) | 2.27730668 |
| 106 | potassium ion homeostasis (GO:0055075) | 2.26516080 |
| 107 | neuron cell-cell adhesion (GO:0007158) | 2.26300182 |
| 108 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.25452477 |
| 109 | neurotransmitter secretion (GO:0007269) | 2.24501405 |
| 110 | positive regulation of fibroblast migration (GO:0010763) | 2.23696296 |
| 111 | presynaptic membrane assembly (GO:0097105) | 2.23342452 |
| 112 | negative T cell selection (GO:0043383) | 2.21432170 |
| 113 | regulation of Rap GTPase activity (GO:0032317) | 2.19400843 |
| 114 | gamma-aminobutyric acid transport (GO:0015812) | 2.19306461 |
| 115 | regulation of cell communication by electrical coupling (GO:0010649) | 2.18426835 |
| 116 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 2.18308309 |
| 117 | positive regulation of muscle hypertrophy (GO:0014742) | 2.17209522 |
| 118 | positive regulation of cardiac muscle hypertrophy (GO:0010613) | 2.17209522 |
| 119 | regulation of neurotransmitter secretion (GO:0046928) | 2.16393203 |
| 120 | regulation of Rac GTPase activity (GO:0032314) | 2.15884450 |
| 121 | germinal center formation (GO:0002467) | 2.14623938 |
| 122 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 2.13906425 |
| 123 | establishment of protein localization to Golgi (GO:0072600) | 2.12772421 |
| 124 | regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882) | 2.12033724 |
| 125 | membrane hyperpolarization (GO:0060081) | 2.12022843 |
| 126 | membrane repolarization during cardiac muscle cell action potential (GO:0086013) | 2.11742278 |
| 127 | membrane depolarization during action potential (GO:0086010) | 2.11592318 |
| 128 | regulation of synapse maturation (GO:0090128) | 2.11539604 |
| 129 | membrane depolarization (GO:0051899) | 2.10947347 |
| 130 | regulation of isotype switching to IgG isotypes (GO:0048302) | 2.10348593 |
| 131 | negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371) | 2.09526648 |
| 132 | negative regulation of T-helper cell differentiation (GO:0045623) | 2.09526648 |
| 133 | positive regulation of membrane potential (GO:0045838) | 2.09512509 |
| 134 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 2.09414797 |
| 135 | sensory perception of smell (GO:0007608) | 2.08809369 |
| 136 | potassium ion transmembrane transport (GO:0071805) | 2.08607937 |
| 137 | cellular potassium ion transport (GO:0071804) | 2.08607937 |
| 138 | cochlea development (GO:0090102) | 2.08136737 |
| 139 | potassium ion transport (GO:0006813) | 2.06569414 |
| 140 | regulation of dendritic spine development (GO:0060998) | 2.06423677 |
| 141 | cellular response to ammonium ion (GO:0071242) | 2.06276257 |
| 142 | positive regulation of calcium ion transmembrane transporter activity (GO:1901021) | 2.05624890 |
| 143 | regulation of calcineurin-NFAT signaling cascade (GO:0070884) | 2.04963800 |
| 144 | negative thymic T cell selection (GO:0045060) | 2.04763781 |
| 145 | regulation of gamma-delta T cell activation (GO:0046643) | 2.04645645 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 3.85554305 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 3.36770684 |
| 3 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.83775923 |
| 4 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.83264000 |
| 5 | FOXP3_17237761_ChIP-ChIP_TREG_Mouse | 2.45352268 |
| 6 | STAT6_20620947_ChIP-Seq_CD4_POS_T_Human | 2.38325714 |
| 7 | DROSHA_22980978_ChIP-Seq_HELA_Human | 2.24962379 |
| 8 | BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse | 2.17858104 |
| 9 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 2.15456182 |
| 10 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.08708023 |
| 11 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.01422592 |
| 12 | TAF15_26573619_Chip-Seq_HEK293_Human | 1.97436312 |
| 13 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.95539730 |
| 14 | SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.89065249 |
| 15 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 1.88329658 |
| 16 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 1.83470855 |
| 17 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 1.78629109 |
| 18 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.73109623 |
| 19 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 1.72164878 |
| 20 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 1.72164878 |
| 21 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 1.72151239 |
| 22 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.70664566 |
| 23 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.66691398 |
| 24 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.65502620 |
| 25 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.64964726 |
| 26 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.62140101 |
| 27 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.59490315 |
| 28 | RUNX_20019798_ChIP-Seq_JUKART_Human | 1.58964904 |
| 29 | SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.57010040 |
| 30 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.56018103 |
| 31 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 1.54529368 |
| 32 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 1.53466963 |
| 33 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 1.51557683 |
| 34 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.50744084 |
| 35 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 1.50503068 |
| 36 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.49819104 |
| 37 | P300_19829295_ChIP-Seq_ESCs_Human | 1.49638219 |
| 38 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.48136518 |
| 39 | RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 1.43886326 |
| 40 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.40316344 |
| 41 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.39975585 |
| 42 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.39765763 |
| 43 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.38075230 |
| 44 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.37032691 |
| 45 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.36701486 |
| 46 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 1.34887425 |
| 47 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.33428319 |
| 48 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.31517655 |
| 49 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.31329971 |
| 50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.31160109 |
| 51 | AR_25329375_ChIP-Seq_VCAP_Human | 1.30858183 |
| 52 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.28085367 |
| 53 | RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.26978467 |
| 54 | SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.25247602 |
| 55 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.24583470 |
| 56 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.23923647 |
| 57 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.23670906 |
| 58 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.23425242 |
| 59 | STAT3_23295773_ChIP-Seq_U87_Human | 1.22742815 |
| 60 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.22522135 |
| 61 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.21886854 |
| 62 | IRF1_21803131_ChIP-Seq_MONOCYTES_Human | 1.21621935 |
| 63 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.20768350 |
| 64 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.20231328 |
| 65 | IRF8_22096565_ChIP-ChIP_GC-B_Human | 1.19887787 |
| 66 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.19273282 |
| 67 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.18176883 |
| 68 | TCF4_18268006_ChIP-ChIP_LS174T_Human | 1.17560950 |
| 69 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 1.16063426 |
| 70 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.15740685 |
| 71 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.15507140 |
| 72 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.14952890 |
| 73 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.13785795 |
| 74 | TCF4_23295773_ChIP-Seq_U87_Human | 1.13540358 |
| 75 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.13458953 |
| 76 | STAT3_20064451_ChIP-Seq_CD4+T_Mouse | 1.13167176 |
| 77 | RXR_22108803_ChIP-Seq_LS180_Human | 1.12857897 |
| 78 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.12469636 |
| 79 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.12026158 |
| 80 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.11202621 |
| 81 | TP53_16413492_ChIP-PET_HCT116_Human | 1.10680901 |
| 82 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.10241807 |
| 83 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.10227504 |
| 84 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.09718177 |
| 85 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.08572963 |
| 86 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.07617399 |
| 87 | SMAD3_21741376_ChIP-Seq_HESCs_Human | 1.05588970 |
| 88 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.05463219 |
| 89 | BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.05039095 |
| 90 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.04692408 |
| 91 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.04376303 |
| 92 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.04205345 |
| 93 | AR_19668381_ChIP-Seq_PC3_Human | 1.03290886 |
| 94 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.03105914 |
| 95 | CTNNB1_20460455_ChIP-Seq_HCT116_Human | 1.02858757 |
| 96 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.02620756 |
| 97 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.99314809 |
| 98 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 0.99269244 |
| 99 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 0.98537903 |
| 100 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 0.98537903 |
| 101 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.98391547 |
| 102 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.98168941 |
| 103 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 0.98168941 |
| 104 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 0.97080346 |
| 105 | VDR_24787735_ChIP-Seq_THP-1_Human | 0.96696841 |
| 106 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 0.96453456 |
| 107 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 0.95688415 |
| 108 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 0.95227365 |
| 109 | CBP_20019798_ChIP-Seq_JUKART_Human | 0.95227365 |
| 110 | RUNX1_17652178_ChIP-ChIP_JURKAT_Human | 0.95092817 |
| 111 | FOXM1_26456572_ChIP-Seq_MCF-7_Human | 0.94947506 |
| 112 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.94526293 |
| 113 | SMAD4_21741376_ChIP-Seq_HESCs_Human | 0.94221021 |
| 114 | VDR_22108803_ChIP-Seq_LS180_Human | 0.93953342 |
| 115 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 0.93931230 |
| 116 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 0.93800643 |
| 117 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 0.93320047 |
| 118 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.93177293 |
| 119 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 0.93116218 |
| 120 | ER_23166858_ChIP-Seq_MCF-7_Human | 0.93070023 |
| 121 | P53_22387025_ChIP-Seq_ESCs_Mouse | 0.92523459 |
| 122 | RUNX2_22187159_ChIP-Seq_PCA_Human | 0.92335869 |
| 123 | TCF4_22108803_ChIP-Seq_LS180_Human | 0.91174148 |
| 124 | TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse | 0.90136275 |
| 125 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.89935035 |
| 126 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.89793530 |
| 127 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86890375 |
| 128 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 0.86632846 |
| 129 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.86540312 |
| 130 | FLI1_21867929_ChIP-Seq_TH2_Mouse | 0.85688074 |
| 131 | KDM2B_26808549_Chip-Seq_REH_Human | 0.83828215 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0004859_abnormal_synaptic_plasticity | 5.21749929 |
| 2 | MP0003880_abnormal_central_pattern | 3.81868220 |
| 3 | MP0005423_abnormal_somatic_nervous | 2.98877220 |
| 4 | MP0002876_abnormal_thyroid_physiology | 2.97752624 |
| 5 | MP0003195_calcinosis | 2.97418176 |
| 6 | MP0001984_abnormal_olfaction | 2.92392972 |
| 7 | MP0003635_abnormal_synaptic_transmissio | 2.91800553 |
| 8 | MP0009745_abnormal_behavioral_response | 2.65664804 |
| 9 | MP0004510_myositis | 2.58371305 |
| 10 | MP0001968_abnormal_touch/_nociception | 2.41745356 |
| 11 | MP0001501_abnormal_sleep_pattern | 2.34671457 |
| 12 | MP0002063_abnormal_learning/memory/cond | 2.34115340 |
| 13 | MP0002735_abnormal_chemical_nociception | 2.29923012 |
| 14 | MP0004885_abnormal_endolymph | 2.25205316 |
| 15 | MP0002064_seizures | 2.20138351 |
| 16 | MP0001873_stomach_inflammation | 2.19060550 |
| 17 | MP0002736_abnormal_nociception_after | 2.10791398 |
| 18 | MP0009046_muscle_twitch | 2.03870183 |
| 19 | MP0004484_altered_response_of | 2.00635784 |
| 20 | MP0002572_abnormal_emotion/affect_behav | 1.98482086 |
| 21 | MP0001756_abnormal_urination | 1.92070272 |
| 22 | MP0010234_abnormal_vibrissa_follicle | 1.91387643 |
| 23 | MP0005310_abnormal_salivary_gland | 1.89068207 |
| 24 | MP0003787_abnormal_imprinting | 1.85124504 |
| 25 | MP0001486_abnormal_startle_reflex | 1.77719000 |
| 26 | MP0003045_fibrosis | 1.69099022 |
| 27 | MP0002733_abnormal_thermal_nociception | 1.67747194 |
| 28 | MP0002272_abnormal_nervous_system | 1.66786061 |
| 29 | MP0003122_maternal_imprinting | 1.66143171 |
| 30 | MP0005646_abnormal_pituitary_gland | 1.59683074 |
| 31 | MP0009780_abnormal_chondrocyte_physiolo | 1.57844547 |
| 32 | MP0002067_abnormal_sensory_capabilities | 1.53826802 |
| 33 | MP0004270_analgesia | 1.50015699 |
| 34 | MP0001765_abnormal_ion_homeostasis | 1.49627330 |
| 35 | MP0001790_abnormal_immune_system | 1.41850081 |
| 36 | MP0005387_immune_system_phenotype | 1.41850081 |
| 37 | MP0008569_lethality_at_weaning | 1.40544188 |
| 38 | MP0004215_abnormal_myocardial_fiber | 1.40404507 |
| 39 | MP0002734_abnormal_mechanical_nocicepti | 1.40097557 |
| 40 | MP0002837_dystrophic_cardiac_calcinosis | 1.39817949 |
| 41 | MP0001440_abnormal_grooming_behavior | 1.37129977 |
| 42 | MP0006276_abnormal_autonomic_nervous | 1.34548995 |
| 43 | MP0008961_abnormal_basal_metabolism | 1.33645588 |
| 44 | MP0001835_abnormal_antigen_presentation | 1.32615077 |
| 45 | MP0002066_abnormal_motor_capabilities/c | 1.31716666 |
| 46 | MP0005409_darkened_coat_color | 1.31486692 |
| 47 | MP0003183_abnormal_peptide_metabolism | 1.30814477 |
| 48 | MP0008874_decreased_physiological_sensi | 1.30735706 |
| 49 | MP0004043_abnormal_pH_regulation | 1.29826701 |
| 50 | MP0000569_abnormal_digit_pigmentation | 1.28747056 |
| 51 | MP0002822_catalepsy | 1.26938908 |
| 52 | MP0001485_abnormal_pinna_reflex | 1.24196122 |
| 53 | MP0003763_abnormal_thymus_physiology | 1.24070050 |
| 54 | MP0003690_abnormal_glial_cell | 1.23095862 |
| 55 | MP0008872_abnormal_physiological_respon | 1.23052984 |
| 56 | MP0003879_abnormal_hair_cell | 1.21856611 |
| 57 | MP0003329_amyloid_beta_deposits | 1.20356038 |
| 58 | MP0003300_gastrointestinal_ulcer | 1.19927356 |
| 59 | MP0008877_abnormal_DNA_methylation | 1.19770884 |
| 60 | MP0001905_abnormal_dopamine_level | 1.19124406 |
| 61 | MP0005166_decreased_susceptibility_to | 1.17516723 |
| 62 | MP0001986_abnormal_taste_sensitivity | 1.15876632 |
| 63 | MP0004147_increased_porphyrin_level | 1.15251287 |
| 64 | MP0002166_altered_tumor_susceptibility | 1.15114446 |
| 65 | MP0001177_atelectasis | 1.12851013 |
| 66 | MP0002638_abnormal_pupillary_reflex | 1.12144290 |
| 67 | MP0001800_abnormal_humoral_immune | 1.11627228 |
| 68 | MP0002882_abnormal_neuron_morphology | 1.11536080 |
| 69 | MP0000920_abnormal_myelination | 1.10925754 |
| 70 | MP0002229_neurodegeneration | 1.10517321 |
| 71 | MP0004019_abnormal_vitamin_homeostasis | 1.09973431 |
| 72 | MP0002006_tumorigenesis | 1.09937366 |
| 73 | MP0001502_abnormal_circadian_rhythm | 1.08215413 |
| 74 | MP0001188_hyperpigmentation | 1.06499687 |
| 75 | MP0005636_abnormal_mineral_homeostasis | 1.04202427 |
| 76 | MP0003075_altered_response_to | 1.03425654 |
| 77 | MP0001963_abnormal_hearing_physiology | 1.03405285 |
| 78 | MP0004742_abnormal_vestibular_system | 1.01943944 |
| 79 | MP0000955_abnormal_spinal_cord | 1.01440571 |
| 80 | MP0005360_urolithiasis | 0.99944388 |
| 81 | MP0000685_abnormal_immune_system | 0.98320654 |
| 82 | MP0005535_abnormal_body_temperature | 0.96849183 |
| 83 | MP0003866_abnormal_defecation | 0.96734885 |
| 84 | MP0005386_behavior/neurological_phenoty | 0.96570717 |
| 85 | MP0004924_abnormal_behavior | 0.96570717 |
| 86 | MP0010155_abnormal_intestine_physiology | 0.95735214 |
| 87 | MP0003633_abnormal_nervous_system | 0.94993594 |
| 88 | MP0005645_abnormal_hypothalamus_physiol | 0.94300750 |
| 89 | MP0002332_abnormal_exercise_endurance | 0.93336272 |
| 90 | MP0002557_abnormal_social/conspecific_i | 0.92817881 |
| 91 | MP0005332_abnormal_amino_acid | 0.92572721 |
| 92 | MP0005671_abnormal_response_to | 0.91331635 |
| 93 | MP0008875_abnormal_xenobiotic_pharmacok | 0.91227478 |
| 94 | MP0009643_abnormal_urine_homeostasis | 0.90371260 |
| 95 | MP0003283_abnormal_digestive_organ | 0.87885467 |
| 96 | MP0006082_CNS_inflammation | 0.87849703 |
| 97 | MP0008004_abnormal_stomach_pH | 0.86300268 |
| 98 | MP0001663_abnormal_digestive_system | 0.85686623 |
| 99 | MP0001664_abnormal_digestion | 0.85519487 |
| 100 | MP0002928_abnormal_bile_duct | 0.85305336 |
| 101 | MP0001970_abnormal_pain_threshold | 0.84796738 |
| 102 | MP0005551_abnormal_eye_electrophysiolog | 0.84743255 |
| 103 | MP0002184_abnormal_innervation | 0.83857821 |
| 104 | MP0002452_abnormal_antigen_presenting | 0.83698338 |
| 105 | MP0000631_abnormal_neuroendocrine_gland | 0.82844927 |
| 106 | MP0005499_abnormal_olfactory_system | 0.81675923 |
| 107 | MP0005394_taste/olfaction_phenotype | 0.81675923 |
| 108 | MP0000778_abnormal_nervous_system | 0.81024283 |
| 109 | MP0002009_preneoplasia | 0.79347509 |
| 110 | MP0001819_abnormal_immune_cell | 0.79030681 |
| 111 | MP0002653_abnormal_ependyma_morphology | 0.78811607 |
| 112 | MP0002420_abnormal_adaptive_immunity | 0.78453131 |
| 113 | MP0003632_abnormal_nervous_system | 0.77848120 |
| 114 | MP0002723_abnormal_immune_serum | 0.77262216 |
| 115 | MP0003252_abnormal_bile_duct | 0.76836227 |
| 116 | MP0004947_skin_inflammation | 0.75737551 |
| 117 | MP0004811_abnormal_neuron_physiology | 0.74727776 |
| 118 | MP0003121_genomic_imprinting | 0.74419061 |
| 119 | MP0002909_abnormal_adrenal_gland | 0.73894191 |
| 120 | MP0002152_abnormal_brain_morphology | 0.73698165 |
| 121 | MP0004130_abnormal_muscle_cell | 0.71840603 |
| 122 | MP0010386_abnormal_urinary_bladder | 0.71644082 |
| 123 | MP0002090_abnormal_vision | 0.71155193 |
| 124 | MP0002136_abnormal_kidney_physiology | 0.70206173 |
| 125 | MP0003631_nervous_system_phenotype | 0.70072454 |
| 126 | MP0000538_abnormal_urinary_bladder | 0.69862845 |
| 127 | MP0009785_altered_susceptibility_to | 0.69734439 |
| 128 | MP0004142_abnormal_muscle_tone | 0.68429755 |
| 129 | MP0005620_abnormal_muscle_contractility | 0.67894770 |
| 130 | MP0002069_abnormal_eating/drinking_beha | 0.67870804 |
| 131 | MP0001346_abnormal_lacrimal_gland | 0.67512643 |
| 132 | MP0000751_myopathy | 0.67046271 |
| 133 | MP0000566_synostosis | 0.67043265 |
| 134 | MP0010678_abnormal_skin_adnexa | 0.65714291 |
| 135 | MP0002138_abnormal_hepatobiliary_system | 0.65661796 |
| 136 | MP0000230_abnormal_systemic_arterial | 0.65171582 |
| 137 | MP0000026_abnormal_inner_ear | 0.65094441 |
| 138 | MP0009764_decreased_sensitivity_to | 0.64925454 |
| 139 | MP0003137_abnormal_impulse_conducting | 0.62612822 |
| 140 | MP0003123_paternal_imprinting | 0.62020913 |
| 141 | MP0005167_abnormal_blood-brain_barrier | 0.59218562 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 6.43934098 |
| 2 | Febrile seizures (HP:0002373) | 5.55127153 |
| 3 | Metabolic alkalosis (HP:0200114) | 4.75995482 |
| 4 | Hyperactive renin-angiotensin system (HP:0000841) | 4.53445959 |
| 5 | Focal seizures (HP:0007359) | 4.14232270 |
| 6 | Epileptic encephalopathy (HP:0200134) | 4.03191896 |
| 7 | Atonic seizures (HP:0010819) | 3.85150706 |
| 8 | Increased circulating renin level (HP:0000848) | 3.77879886 |
| 9 | Abnormality of chloride homeostasis (HP:0011422) | 3.72768668 |
| 10 | Gout (HP:0001997) | 3.48512705 |
| 11 | Hyperaldosteronism (HP:0000859) | 3.45836050 |
| 12 | Decreased circulating renin level (HP:0003351) | 3.30568388 |
| 13 | Abnormality of renin-angiotensin system (HP:0000847) | 3.22579460 |
| 14 | Hyperventilation (HP:0002883) | 3.17743607 |
| 15 | Abnormality of sodium homeostasis (HP:0010931) | 3.15110155 |
| 16 | Hypokalemic alkalosis (HP:0001949) | 3.08853072 |
| 17 | Abnormal eating behavior (HP:0100738) | 3.00851961 |
| 18 | Absence seizures (HP:0002121) | 3.00151398 |
| 19 | Abnormality of the fingertips (HP:0001211) | 2.97715215 |
| 20 | Gaze-evoked nystagmus (HP:0000640) | 2.89453245 |
| 21 | Agammaglobulinemia (HP:0004432) | 2.87631840 |
| 22 | Polyuria (HP:0000103) | 2.82763321 |
| 23 | Thyroiditis (HP:0100646) | 2.78324673 |
| 24 | Scanning speech (HP:0002168) | 2.71871884 |
| 25 | Dialeptic seizures (HP:0011146) | 2.71218321 |
| 26 | Hypercalciuria (HP:0002150) | 2.70963043 |
| 27 | Polydipsia (HP:0001959) | 2.63061385 |
| 28 | Abnormal drinking behavior (HP:0030082) | 2.63061385 |
| 29 | Hyponatremia (HP:0002902) | 2.62930965 |
| 30 | Tubular atrophy (HP:0000092) | 2.61854624 |
| 31 | Abnormal urine output (HP:0012590) | 2.61473515 |
| 32 | Progressive cerebellar ataxia (HP:0002073) | 2.59592063 |
| 33 | Abnormality of renal excretion (HP:0011036) | 2.58149346 |
| 34 | Torticollis (HP:0000473) | 2.56596141 |
| 35 | Generalized tonic-clonic seizures (HP:0002069) | 2.51829506 |
| 36 | Papilledema (HP:0001085) | 2.49512050 |
| 37 | Ankle clonus (HP:0011448) | 2.40225555 |
| 38 | Autoimmune thrombocytopenia (HP:0001973) | 2.40051603 |
| 39 | Chronic diarrhea (HP:0002028) | 2.39138445 |
| 40 | Tetany (HP:0001281) | 2.37850225 |
| 41 | Fair hair (HP:0002286) | 2.36055721 |
| 42 | Limb dystonia (HP:0002451) | 2.34413646 |
| 43 | Mitral stenosis (HP:0001718) | 2.33910884 |
| 44 | Hypomagnesemia (HP:0002917) | 2.31932547 |
| 45 | Mutism (HP:0002300) | 2.31513165 |
| 46 | Abnormality of potassium homeostasis (HP:0011042) | 2.30996841 |
| 47 | Abnormality of B cell number (HP:0010975) | 2.29167837 |
| 48 | B lymphocytopenia (HP:0010976) | 2.29167837 |
| 49 | Visual hallucinations (HP:0002367) | 2.27705135 |
| 50 | Supranuclear gaze palsy (HP:0000605) | 2.26842723 |
| 51 | Anxiety (HP:0000739) | 2.26603187 |
| 52 | Dysmetric saccades (HP:0000641) | 2.25909498 |
| 53 | Status epilepticus (HP:0002133) | 2.23593753 |
| 54 | Generalized hypopigmentation of hair (HP:0011358) | 2.20464748 |
| 55 | Large eyes (HP:0001090) | 2.18999074 |
| 56 | Hyperkalemia (HP:0002153) | 2.15999581 |
| 57 | Syncope (HP:0001279) | 2.12612670 |
| 58 | Impaired social interactions (HP:0000735) | 2.11238558 |
| 59 | Abnormal social behavior (HP:0012433) | 2.11238558 |
| 60 | Annular pancreas (HP:0001734) | 2.10436770 |
| 61 | Hemiplegia (HP:0002301) | 2.07905473 |
| 62 | Hemiparesis (HP:0001269) | 2.06919565 |
| 63 | Hypokalemia (HP:0002900) | 2.06314431 |
| 64 | Onycholysis (HP:0001806) | 2.06024973 |
| 65 | Genetic anticipation (HP:0003743) | 2.05532273 |
| 66 | Toxemia of pregnancy (HP:0100603) | 2.04910643 |
| 67 | Spastic gait (HP:0002064) | 2.04874279 |
| 68 | Broad-based gait (HP:0002136) | 2.02880399 |
| 69 | Epileptiform EEG discharges (HP:0011182) | 2.01365620 |
| 70 | Alkalosis (HP:0001948) | 2.01102010 |
| 71 | Abnormal hair whorl (HP:0010721) | 2.00977062 |
| 72 | Papilloma (HP:0012740) | 2.00631927 |
| 73 | Verrucae (HP:0200043) | 2.00631927 |
| 74 | Right ventricular cardiomyopathy (HP:0011663) | 2.00127942 |
| 75 | Panhypogammaglobulinemia (HP:0003139) | 2.00077384 |
| 76 | Focal dystonia (HP:0004373) | 1.98900146 |
| 77 | Excessive salivation (HP:0003781) | 1.97485916 |
| 78 | Drooling (HP:0002307) | 1.97485916 |
| 79 | Myokymia (HP:0002411) | 1.96439384 |
| 80 | Poor eye contact (HP:0000817) | 1.96203902 |
| 81 | Intention tremor (HP:0002080) | 1.95557300 |
| 82 | Truncal ataxia (HP:0002078) | 1.94802304 |
| 83 | Widely spaced teeth (HP:0000687) | 1.93433732 |
| 84 | Postural instability (HP:0002172) | 1.93222288 |
| 85 | Central scotoma (HP:0000603) | 1.93071701 |
| 86 | Dysdiadochokinesis (HP:0002075) | 1.92207869 |
| 87 | Nephrogenic diabetes insipidus (HP:0009806) | 1.90019620 |
| 88 | Neurofibrillary tangles (HP:0002185) | 1.89274077 |
| 89 | Recurrent viral infections (HP:0004429) | 1.88565526 |
| 90 | Vertebral arch anomaly (HP:0008438) | 1.88228948 |
| 91 | Congenital stationary night blindness (HP:0007642) | 1.88102698 |
| 92 | Abnormality of the nasal septum (HP:0000419) | 1.87518999 |
| 93 | Recurrent fungal infections (HP:0002841) | 1.85103781 |
| 94 | Adrenal overactivity (HP:0002717) | 1.85101386 |
| 95 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 1.84848520 |
| 96 | Absent/shortened dynein arms (HP:0200106) | 1.84848520 |
| 97 | Milia (HP:0001056) | 1.84211552 |
| 98 | Abnormality of the renal medulla (HP:0100957) | 1.83867892 |
| 99 | Polyphagia (HP:0002591) | 1.83436979 |
| 100 | Proximal tubulopathy (HP:0000114) | 1.83396158 |
| 101 | Dehydration (HP:0001944) | 1.82590432 |
| 102 | Craniofacial dystonia (HP:0012179) | 1.80528768 |
| 103 | Colitis (HP:0002583) | 1.78991312 |
| 104 | Abnormality of magnesium homeostasis (HP:0004921) | 1.78800392 |
| 105 | Dysmetria (HP:0001310) | 1.77270322 |
| 106 | Abnormality of T cell number (HP:0011839) | 1.76316885 |
| 107 | EEG with generalized epileptiform discharges (HP:0011198) | 1.74131490 |
| 108 | Abnormal delayed hypersensitivity skin test (HP:0002963) | 1.73383648 |
| 109 | Amblyopia (HP:0000646) | 1.73344432 |
| 110 | T lymphocytopenia (HP:0005403) | 1.73232702 |
| 111 | Increased purine levels (HP:0004368) | 1.72574579 |
| 112 | Hyperuricemia (HP:0002149) | 1.72574579 |
| 113 | Ventricular fibrillation (HP:0001663) | 1.72445354 |
| 114 | Chronic sinusitis (HP:0011109) | 1.72183901 |
| 115 | Severe combined immunodeficiency (HP:0004430) | 1.71950596 |
| 116 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.71896806 |
| 117 | Cerebral hypomyelination (HP:0006808) | 1.71590386 |
| 118 | Deeply set eye (HP:0000490) | 1.67000804 |
| 119 | Hypsarrhythmia (HP:0002521) | 1.66491918 |
| 120 | Diplopia (HP:0000651) | 1.66311194 |
| 121 | Abnormality of binocular vision (HP:0011514) | 1.66311194 |
| 122 | Confusion (HP:0001289) | 1.65353750 |
| 123 | Blue irides (HP:0000635) | 1.64574111 |
| 124 | Recurrent cutaneous fungal infections (HP:0011370) | 1.64539734 |
| 125 | Chronic mucocutaneous candidiasis (HP:0002728) | 1.64539734 |
| 126 | Absent speech (HP:0001344) | 1.64248277 |
| 127 | Abnormality of salivation (HP:0100755) | 1.64176725 |
| 128 | Abnormality of the renal cortex (HP:0011035) | 1.63482909 |
| 129 | Arterial tortuosity (HP:0005116) | 1.61737126 |
| 130 | Depression (HP:0000716) | 1.61113028 |
| 131 | Abnormality of purine metabolism (HP:0004352) | 1.60709770 |
| 132 | Nephrocalcinosis (HP:0000121) | 1.60382071 |
| 133 | Chronic hepatic failure (HP:0100626) | 1.60371978 |
| 134 | Abnormality of macular pigmentation (HP:0008002) | 1.60168134 |
| 135 | Urinary bladder sphincter dysfunction (HP:0002839) | 1.59619127 |
| 136 | Action tremor (HP:0002345) | 1.59112696 |
| 137 | Spastic tetraparesis (HP:0001285) | 1.58776003 |
| 138 | Hypotension (HP:0002615) | 1.57304334 |
| 139 | Renal salt wasting (HP:0000127) | 1.57052890 |
| 140 | Thyroid-stimulating hormone excess (HP:0002925) | 1.56739751 |
| 141 | Gait imbalance (HP:0002141) | 1.56680512 |
| 142 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.56600363 |
| 143 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.56600363 |
| 144 | Impaired smooth pursuit (HP:0007772) | 1.56223754 |
| 145 | Tetraplegia (HP:0002445) | 1.56055391 |
| 146 | Thickened helices (HP:0000391) | 1.55724630 |
| 147 | Urethral obstruction (HP:0000796) | 1.55370480 |
| 148 | Facial shape deformation (HP:0011334) | 1.54914468 |
| 149 | Potter facies (HP:0002009) | 1.54914468 |
| 150 | Aplasia cutis congenita (HP:0001057) | 1.54307272 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EPHA4 | 3.83719363 |
| 2 | NTRK3 | 3.45706923 |
| 3 | RIPK4 | 2.83601087 |
| 4 | FRK | 2.76547934 |
| 5 | MARK1 | 2.45927208 |
| 6 | MAP2K7 | 2.45567981 |
| 7 | MAP3K13 | 2.35317558 |
| 8 | PRPF4B | 2.19834007 |
| 9 | SGK2 | 2.14085912 |
| 10 | TAOK3 | 2.05717191 |
| 11 | MAP3K4 | 2.04108400 |
| 12 | TXK | 1.98213437 |
| 13 | UHMK1 | 1.98184750 |
| 14 | STK39 | 1.89816033 |
| 15 | BMPR2 | 1.86318100 |
| 16 | SGK3 | 1.80559347 |
| 17 | PRKD3 | 1.79978857 |
| 18 | MAP3K12 | 1.79092965 |
| 19 | MAP3K14 | 1.71317472 |
| 20 | CASK | 1.69721899 |
| 21 | MAP3K7 | 1.66899074 |
| 22 | DAPK2 | 1.62946117 |
| 23 | NTRK2 | 1.60675059 |
| 24 | FES | 1.54437237 |
| 25 | OXSR1 | 1.42887741 |
| 26 | SGK223 | 1.38619173 |
| 27 | SGK494 | 1.38619173 |
| 28 | CAMKK2 | 1.37817185 |
| 29 | PLK2 | 1.34173410 |
| 30 | MAP4K1 | 1.30160228 |
| 31 | JAK1 | 1.24619824 |
| 32 | TNK2 | 1.23065444 |
| 33 | MAP3K9 | 1.22619363 |
| 34 | WNK3 | 1.19706848 |
| 35 | MAP2K4 | 1.19262201 |
| 36 | GRK5 | 1.18197994 |
| 37 | SIK3 | 1.16933576 |
| 38 | SIK2 | 1.14869314 |
| 39 | FGFR3 | 1.13301015 |
| 40 | PTK2B | 1.09014193 |
| 41 | INSRR | 1.08065289 |
| 42 | GRK6 | 1.07354153 |
| 43 | DAPK1 | 1.05896989 |
| 44 | CAMK1G | 1.03519018 |
| 45 | SGK1 | 1.03309556 |
| 46 | MAPK7 | 1.02901623 |
| 47 | MST4 | 1.00454187 |
| 48 | PHKG1 | 0.96900452 |
| 49 | PHKG2 | 0.96900452 |
| 50 | NTRK1 | 0.96813788 |
| 51 | FER | 0.94227680 |
| 52 | STK38 | 0.89964631 |
| 53 | SYK | 0.86393643 |
| 54 | PRKCH | 0.86101187 |
| 55 | PRKCQ | 0.86019542 |
| 56 | WNK4 | 0.84935786 |
| 57 | MAPK12 | 0.83633897 |
| 58 | CDK19 | 0.82674520 |
| 59 | MAP3K6 | 0.82253094 |
| 60 | LMTK2 | 0.80053577 |
| 61 | STK11 | 0.80033729 |
| 62 | CDK9 | 0.79937461 |
| 63 | KSR1 | 0.79224580 |
| 64 | PIK3CA | 0.78477593 |
| 65 | NUAK1 | 0.77266960 |
| 66 | CDK5 | 0.76949614 |
| 67 | NME1 | 0.75355742 |
| 68 | CAMK1D | 0.71180837 |
| 69 | PRKCG | 0.68652391 |
| 70 | DMPK | 0.67863183 |
| 71 | FGFR2 | 0.66946017 |
| 72 | PRKCE | 0.65528651 |
| 73 | CAMK2B | 0.65422235 |
| 74 | RIPK1 | 0.65391538 |
| 75 | CAMK2A | 0.65312061 |
| 76 | MST1R | 0.65024672 |
| 77 | WNK1 | 0.64860537 |
| 78 | PDK1 | 0.64764445 |
| 79 | CAMKK1 | 0.63691089 |
| 80 | ADRBK2 | 0.63297504 |
| 81 | HCK | 0.62228091 |
| 82 | AKT3 | 0.61552226 |
| 83 | JAK3 | 0.60308270 |
| 84 | CAMK1 | 0.59808692 |
| 85 | CHUK | 0.59467987 |
| 86 | PDGFRB | 0.57636829 |
| 87 | STK24 | 0.56597261 |
| 88 | CAMK2D | 0.56408356 |
| 89 | MAP2K6 | 0.55714540 |
| 90 | NEK6 | 0.55623797 |
| 91 | CSNK1A1 | 0.54537765 |
| 92 | IKBKE | 0.54321006 |
| 93 | TIE1 | 0.53890625 |
| 94 | RPS6KB1 | 0.53522723 |
| 95 | MINK1 | 0.52946195 |
| 96 | MAPK13 | 0.50253779 |
| 97 | MAP3K2 | 0.50241702 |
| 98 | RET | 0.48381332 |
| 99 | MAPK15 | 0.48261682 |
| 100 | TYRO3 | 0.48141077 |
| 101 | CDK15 | 0.48120248 |
| 102 | CAMK4 | 0.47546316 |
| 103 | KSR2 | 0.47135480 |
| 104 | PAK6 | 0.46975972 |
| 105 | ZAK | 0.46689379 |
| 106 | PRKAA2 | 0.46501339 |
| 107 | RAF1 | 0.46022755 |
| 108 | EPHA3 | 0.45936199 |
| 109 | CDK18 | 0.45933414 |
| 110 | DYRK1A | 0.45873904 |
| 111 | BMPR1B | 0.45683131 |
| 112 | PRKCZ | 0.45408131 |
| 113 | MAP3K1 | 0.45307218 |
| 114 | CDK12 | 0.45268142 |
| 115 | PAK3 | 0.44889837 |
| 116 | LATS2 | 0.44732589 |
| 117 | RPS6KA3 | 0.44474872 |
| 118 | PRKCA | 0.44294238 |
| 119 | TRPM7 | 0.43752510 |
| 120 | ALK | 0.43666343 |
| 121 | CDK3 | 0.42658263 |
| 122 | MAP3K5 | 0.42092314 |
| 123 | PDPK1 | 0.40819438 |
| 124 | CAMK2G | 0.40629899 |
| 125 | ERBB3 | 0.40133568 |
| 126 | PRKACA | 0.39894192 |
| 127 | CDK14 | 0.39855062 |
| 128 | PINK1 | 0.39847481 |
| 129 | NLK | 0.39526999 |
| 130 | GRK1 | 0.39235890 |
| 131 | PNCK | 0.37687277 |
| 132 | CDK11A | 0.37387926 |
| 133 | MARK2 | 0.37042752 |
| 134 | PKN1 | 0.35854435 |
| 135 | ERBB2 | 0.35301130 |
| 136 | ARAF | 0.31005287 |
| 137 | PRKAA1 | 0.28702494 |
| 138 | MAPK10 | 0.27552894 |
| 139 | TRIM28 | 0.27443374 |
| 140 | LIMK1 | 0.25967505 |
| 141 | PRKG1 | 0.24074871 |
| 142 | CSNK1G2 | 0.22991723 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 2.94533127 |
| 2 | Olfactory transduction_Homo sapiens_hsa04740 | 2.25635846 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.11444116 |
| 4 | Circadian entrainment_Homo sapiens_hsa04713 | 2.05802518 |
| 5 | Morphine addiction_Homo sapiens_hsa05032 | 1.99345592 |
| 6 | Long-term potentiation_Homo sapiens_hsa04720 | 1.98264917 |
| 7 | Salivary secretion_Homo sapiens_hsa04970 | 1.96999803 |
| 8 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 1.95073070 |
| 9 | Glutamatergic synapse_Homo sapiens_hsa04724 | 1.79766180 |
| 10 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 1.78657413 |
| 11 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.75331156 |
| 12 | GABAergic synapse_Homo sapiens_hsa04727 | 1.67236077 |
| 13 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.62126813 |
| 14 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.54592008 |
| 15 | Taste transduction_Homo sapiens_hsa04742 | 1.54082516 |
| 16 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.53734883 |
| 17 | Renin secretion_Homo sapiens_hsa04924 | 1.51523576 |
| 18 | Phototransduction_Homo sapiens_hsa04744 | 1.45544724 |
| 19 | Histidine metabolism_Homo sapiens_hsa00340 | 1.38783298 |
| 20 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.36960217 |
| 21 | Insulin secretion_Homo sapiens_hsa04911 | 1.35908983 |
| 22 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.34656370 |
| 23 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.33802855 |
| 24 | Primary immunodeficiency_Homo sapiens_hsa05340 | 1.32886902 |
| 25 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 1.30397848 |
| 26 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.29282494 |
| 27 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.26606358 |
| 28 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.25259189 |
| 29 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 1.20975490 |
| 30 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.20043414 |
| 31 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 1.19296962 |
| 32 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.15738770 |
| 33 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.15551011 |
| 34 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.14330474 |
| 35 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.09750685 |
| 36 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.08225498 |
| 37 | Pancreatic secretion_Homo sapiens_hsa04972 | 1.04759566 |
| 38 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.03439276 |
| 39 | Long-term depression_Homo sapiens_hsa04730 | 1.03311255 |
| 40 | Serotonergic synapse_Homo sapiens_hsa04726 | 1.01314519 |
| 41 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.98679519 |
| 42 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.98400376 |
| 43 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.97367166 |
| 44 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.97054240 |
| 45 | T cell receptor signaling pathway_Homo sapiens_hsa04660 | 0.95465134 |
| 46 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.94748499 |
| 47 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.92339296 |
| 48 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.91953861 |
| 49 | B cell receptor signaling pathway_Homo sapiens_hsa04662 | 0.91242641 |
| 50 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.90104219 |
| 51 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 0.88977231 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.85823151 |
| 53 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.83850159 |
| 54 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.83738615 |
| 55 | Mineral absorption_Homo sapiens_hsa04978 | 0.83243714 |
| 56 | Bile secretion_Homo sapiens_hsa04976 | 0.81760052 |
| 57 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.81555989 |
| 58 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.81044298 |
| 59 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.80230523 |
| 60 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.79981186 |
| 61 | Osteoclast differentiation_Homo sapiens_hsa04380 | 0.78208589 |
| 62 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.77726150 |
| 63 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.75355283 |
| 64 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 0.75248237 |
| 65 | Allograft rejection_Homo sapiens_hsa05330 | 0.74980232 |
| 66 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.74761017 |
| 67 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.74318354 |
| 68 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.73776641 |
| 69 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.73681851 |
| 70 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.73126016 |
| 71 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.72462734 |
| 72 | Glioma_Homo sapiens_hsa05214 | 0.70451138 |
| 73 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.68956253 |
| 74 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.68475885 |
| 75 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.67547451 |
| 76 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.66439851 |
| 77 | Circadian rhythm_Homo sapiens_hsa04710 | 0.65493289 |
| 78 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.65029859 |
| 79 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.62361286 |
| 80 | Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321 | 0.61978928 |
| 81 | Melanogenesis_Homo sapiens_hsa04916 | 0.60964716 |
| 82 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.60876101 |
| 83 | Tuberculosis_Homo sapiens_hsa05152 | 0.60568387 |
| 84 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.60339644 |
| 85 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.60234947 |
| 86 | Leishmaniasis_Homo sapiens_hsa05140 | 0.59131419 |
| 87 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.57842676 |
| 88 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.57654805 |
| 89 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.56727161 |
| 90 | Toxoplasmosis_Homo sapiens_hsa05145 | 0.56691219 |
| 91 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.56555571 |
| 92 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 0.54892539 |
| 93 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.53757889 |
| 94 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.52745841 |
| 95 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.52346679 |
| 96 | Cocaine addiction_Homo sapiens_hsa05030 | 0.51253948 |
| 97 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.50694403 |
| 98 | Platelet activation_Homo sapiens_hsa04611 | 0.50253569 |
| 99 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.49940027 |
| 100 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.49864193 |
| 101 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.49702079 |
| 102 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.49616634 |
| 103 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.49589256 |
| 104 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.49533003 |
| 105 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.49492300 |
| 106 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49071361 |
| 107 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.48117785 |
| 108 | Endometrial cancer_Homo sapiens_hsa05213 | 0.47993005 |
| 109 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.47871183 |
| 110 | ABC transporters_Homo sapiens_hsa02010 | 0.47440965 |
| 111 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.47425242 |
| 112 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.47411793 |
| 113 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.47305139 |
| 114 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.46737432 |
| 115 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.46357156 |
| 116 | Gap junction_Homo sapiens_hsa04540 | 0.45528227 |
| 117 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.45384106 |
| 118 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.45058423 |
| 119 | Insulin resistance_Homo sapiens_hsa04931 | 0.44871285 |
| 120 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.44725459 |
| 121 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.44484402 |
| 122 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.43757670 |
| 123 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.43637578 |
| 124 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.40093634 |
| 125 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.39173295 |
| 126 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.35686187 |
| 127 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.34862982 |
| 128 | Axon guidance_Homo sapiens_hsa04360 | 0.33496313 |
| 129 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.33209376 |
| 130 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.32958349 |
| 131 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.32444422 |
| 132 | Alzheimers disease_Homo sapiens_hsa05010 | 0.29817110 |
| 133 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.29071496 |
| 134 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.25730317 |
| 135 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.25681846 |

