ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	5.22067561
2	L-fucose catabolic process (GO:0042355)	4.08462705
3	fucose catabolic process (GO:0019317)	4.08462705
4	L-fucose metabolic process (GO:0042354)	4.08462705
5	kynurenine metabolic process (GO:0070189)	3.91510340
6	reciprocal DNA recombination (GO:0035825)	3.88328040
7	reciprocal meiotic recombination (GO:0007131)	3.88328040
8	indole-containing compound catabolic process (GO:0042436)	3.74480964
9	indolalkylamine catabolic process (GO:0046218)	3.74480964
10	tryptophan catabolic process (GO:0006569)	3.74480964
11	indolalkylamine metabolic process (GO:0006586)	3.61508710
12	DNA deamination (GO:0045006)	3.60274898
13	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.59311423
14	cellular ketone body metabolic process (GO:0046950)	3.51711865
15	regulation of hippo signaling (GO:0035330)	3.51592664
16	negative regulation of translation, ncRNA-mediated (GO:0040033)	3.39588339
17	regulation of translation, ncRNA-mediated (GO:0045974)	3.39588339
18	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	3.39588339
19	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.38225193
20	neural tube formation (GO:0001841)	3.36350419
21	water-soluble vitamin biosynthetic process (GO:0042364)	3.36075615
22	double-strand break repair via homologous recombination (GO:0000724)	3.33874308
23	recombinational repair (GO:0000725)	3.32158181
24	sulfation (GO:0051923)	3.30045454
25	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.29080608
26	preassembly of GPI anchor in ER membrane (GO:0016254)	3.26090678
27	protein K6-linked ubiquitination (GO:0085020)	3.24973542
28	tryptophan metabolic process (GO:0006568)	3.22539773
29	ketone body metabolic process (GO:1902224)	3.17687365
30	RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)	3.13524121
31	positive regulation of developmental pigmentation (GO:0048087)	3.12418561
32	maturation of 5.8S rRNA (GO:0000460)	3.09800106
33	nephron tubule morphogenesis (GO:0072078)	3.08250186
34	nephron epithelium morphogenesis (GO:0072088)	3.08250186
35	regulation of gene silencing by miRNA (GO:0060964)	3.06103232
36	regulation of gene silencing by RNA (GO:0060966)	3.06103232
37	regulation of posttranscriptional gene silencing (GO:0060147)	3.06103232
38	response to pheromone (GO:0019236)	3.05862118
39	kidney morphogenesis (GO:0060993)	3.05506481
40	detection of light stimulus involved in sensory perception (GO:0050962)	3.01213265
41	detection of light stimulus involved in visual perception (GO:0050908)	3.01213265
42	respiratory chain complex IV assembly (GO:0008535)	3.01080260
43	DNA double-strand break processing (GO:0000729)	2.99853592
44	axoneme assembly (GO:0035082)	2.99039326
45	cellular response to ATP (GO:0071318)	2.94838701
46	replication fork processing (GO:0031297)	2.94710443
47	rRNA catabolic process (GO:0016075)	2.92065002
48	piRNA metabolic process (GO:0034587)	2.89408985
49	protein K11-linked deubiquitination (GO:0035871)	2.84301808
50	cilium or flagellum-dependent cell motility (GO:0001539)	2.84034533
51	protein-cofactor linkage (GO:0018065)	2.83786036
52	somatic hypermutation of immunoglobulin genes (GO:0016446)	2.83655610
53	somatic diversification of immune receptors via somatic mutation (GO:0002566)	2.83655610
54	negative regulation of mast cell activation (GO:0033004)	2.83094338
55	reflex (GO:0060004)	2.81158049
56	cornea development in camera-type eye (GO:0061303)	2.79645857
57	regulation of pigment cell differentiation (GO:0050932)	2.77267388
58	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.75067186
59	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.74559773
60	regulation of mitotic spindle checkpoint (GO:1903504)	2.74559773
61	male meiosis I (GO:0007141)	2.70132817
62	positive regulation of fatty acid transport (GO:2000193)	2.69465979
63	mannosylation (GO:0097502)	2.68117368
64	cilium morphogenesis (GO:0060271)	2.68101332
65	photoreceptor cell maintenance (GO:0045494)	2.67746570
66	spinal cord motor neuron differentiation (GO:0021522)	2.64498407
67	platelet dense granule organization (GO:0060155)	2.63102742
68	prenylation (GO:0097354)	2.62395318
69	protein prenylation (GO:0018342)	2.62395318
70	neuronal action potential (GO:0019228)	2.61944436
71	negative regulation of reactive oxygen species metabolic process (GO:2000378)	2.60868848
72	positive regulation of prostaglandin secretion (GO:0032308)	2.58472003
73	nonmotile primary cilium assembly (GO:0035058)	2.57767389
74	regulation of hexokinase activity (GO:1903299)	2.56426367
75	regulation of glucokinase activity (GO:0033131)	2.56426367
76	S-adenosylmethionine metabolic process (GO:0046500)	2.55220403
77	cilium organization (GO:0044782)	2.55093844
78	epithelial cilium movement (GO:0003351)	2.54539739
79	oxidative demethylation (GO:0070989)	2.53251942
80	DNA demethylation (GO:0080111)	2.53132748
81	somite development (GO:0061053)	2.52899697
82	negative regulation of cell aging (GO:0090344)	2.52782423
83	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.52044698
84	synapsis (GO:0007129)	2.50880167
85	cAMP catabolic process (GO:0006198)	2.50758634
86	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.50677232
87	cytochrome complex assembly (GO:0017004)	2.50373100
88	amino acid salvage (GO:0043102)	2.50351314
89	L-methionine salvage (GO:0071267)	2.50351314
90	L-methionine biosynthetic process (GO:0071265)	2.50351314
91	basic amino acid transport (GO:0015802)	2.50032210
92	dopamine transport (GO:0015872)	2.49425977
93	regulation of action potential (GO:0098900)	2.48885238
94	gamma-aminobutyric acid transport (GO:0015812)	2.46971591
95	cilium assembly (GO:0042384)	2.45814149
96	regulation of mesoderm development (GO:2000380)	2.45552960
97	mitochondrial respiratory chain complex I assembly (GO:0032981)	2.44938890
98	NADH dehydrogenase complex assembly (GO:0010257)	2.44938890
99	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	2.44938890
100	ubiquinone biosynthetic process (GO:0006744)	2.44769560

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	3.76810450
2	VDR_22108803_ChIP-Seq_LS180_Human	3.24786819
3	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.14213285
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.76638438
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.58797491
6	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.50553409
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.48613711
8	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.44466301
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.41873020
10	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.39726857
11	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.37033209
12	EWS_26573619_Chip-Seq_HEK293_Human	2.35289340
13	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.31551076
14	FUS_26573619_Chip-Seq_HEK293_Human	2.23313479
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.20382374
16	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.12125892
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.09685431
18	ER_23166858_ChIP-Seq_MCF-7_Human	2.06646603
19	P300_19829295_ChIP-Seq_ESCs_Human	2.03147917
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.03090376
21	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.02050323
22	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.99349931
23	IRF1_19129219_ChIP-ChIP_H3396_Human	1.98601738
24	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.92160448
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.88029655
26	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.85357146
27	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.80366182
28	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77392031
29	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.77125538
30	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.67773870
31	STAT3_23295773_ChIP-Seq_U87_Human	1.64068824
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.58230347
33	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.57558660
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.57315123
35	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.55479377
36	TP53_22573176_ChIP-Seq_HFKS_Human	1.55146252
37	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.54419592
38	CBP_20019798_ChIP-Seq_JUKART_Human	1.51512438
39	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.51512438
40	TCF4_23295773_ChIP-Seq_U87_Human	1.48036426
41	ELK1_19687146_ChIP-ChIP_HELA_Human	1.47903482
42	VDR_23849224_ChIP-Seq_CD4+_Human	1.45029735
43	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.44437456
44	BCAT_22108803_ChIP-Seq_LS180_Human	1.42923737
45	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.42024732
46	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.41868574
47	SMAD4_21799915_ChIP-Seq_A2780_Human	1.40619961
48	GATA1_22025678_ChIP-Seq_K562_Human	1.35745705
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.32505296
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.32135356
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.31642625
52	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.31642625
53	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.31132399
54	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.30079103
55	AR_25329375_ChIP-Seq_VCAP_Human	1.29547616
56	TCF4_22108803_ChIP-Seq_LS180_Human	1.29406097
57	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.28417123
58	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.28273117
59	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.27657350
60	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.27463449
61	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.26710584
62	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.25444155
63	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.24333810
64	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24279480
65	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24279480
66	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.24071665
67	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.23531077
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.23091104
69	HOXB7_26014856_ChIP-Seq_BT474_Human	1.19819490
70	TP53_16413492_ChIP-PET_HCT116_Human	1.18658156
71	SOX2_19829295_ChIP-Seq_ESCs_Human	1.17645816
72	NANOG_19829295_ChIP-Seq_ESCs_Human	1.17645816
73	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.15818674
74	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.15787025
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14381631
76	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.14243808
77	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.14129892
78	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.11448412
79	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.11036550
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.09987706
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.09506753
82	AR_21572438_ChIP-Seq_LNCaP_Human	1.09361462
83	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.09322623
84	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08856391
85	CDX2_22108803_ChIP-Seq_LS180_Human	1.08170179
86	NCOR_22424771_ChIP-Seq_293T_Human	1.06955749
87	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.06683936
88	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.06569707
89	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.06116783
90	AR_20517297_ChIP-Seq_VCAP_Human	1.05865236
91	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.04958306
92	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.03636978
93	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.03166115
94	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.02045719
95	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.01607042
96	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99955599
97	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.99677396
98	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.99544736
99	NANOG_18555785_Chip-Seq_ESCs_Mouse	0.98494749
100	RNF2_27304074_Chip-Seq_NSC_Mouse	0.97612958

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	3.72425262
2	MP0003195_calcinosis	3.47966608
3	MP0000569_abnormal_digit_pigmentation	2.76904714
4	MP0002102_abnormal_ear_morphology	2.67292373
5	MP0003136_yellow_coat_color	2.46913974
6	MP0001986_abnormal_taste_sensitivity	2.41943298
7	MP0005551_abnormal_eye_electrophysiolog	2.41506819
8	MP0000427_abnormal_hair_cycle	2.30523603
9	MP0002837_dystrophic_cardiac_calcinosis	2.23385486
10	MP0002876_abnormal_thyroid_physiology	2.20388491
11	MP0003787_abnormal_imprinting	2.00657203
12	MP0002638_abnormal_pupillary_reflex	1.98234871
13	MP0008875_abnormal_xenobiotic_pharmacok	1.92367066
14	MP0003646_muscle_fatigue	1.92272309
15	MP0005253_abnormal_eye_physiology	1.91517728
16	MP0005174_abnormal_tail_pigmentation	1.87939690
17	MP0008057_abnormal_DNA_replication	1.87736414
18	MP0006072_abnormal_retinal_apoptosis	1.84732854
19	MP0005085_abnormal_gallbladder_physiolo	1.77379733
20	MP0005645_abnormal_hypothalamus_physiol	1.75591610
21	MP0000383_abnormal_hair_follicle	1.74029987
22	MP0002938_white_spotting	1.73056283
23	MP0004142_abnormal_muscle_tone	1.70290285
24	MP0004133_heterotaxia	1.68923354
25	MP0001968_abnormal_touch/_nociception	1.67810060
26	MP0002160_abnormal_reproductive_system	1.67646671
27	MP0000372_irregular_coat_pigmentation	1.62316078
28	MP0004043_abnormal_pH_regulation	1.59374464
29	MP0000631_abnormal_neuroendocrine_gland	1.57349610
30	MP0006292_abnormal_olfactory_placode	1.55671718
31	MP0005389_reproductive_system_phenotype	1.51036970
32	MP0009046_muscle_twitch	1.46262589
33	MP0008872_abnormal_physiological_respon	1.46000086
34	MP0002928_abnormal_bile_duct	1.38962211
35	MP0001485_abnormal_pinna_reflex	1.37991188
36	MP0005646_abnormal_pituitary_gland	1.37746003
37	MP0002653_abnormal_ependyma_morphology	1.37196291
38	MP0003890_abnormal_embryonic-extraembry	1.36114987
39	MP0003011_delayed_dark_adaptation	1.35856016
40	MP0002138_abnormal_hepatobiliary_system	1.35559647
41	MP0003718_maternal_effect	1.33661586
42	MP0002095_abnormal_skin_pigmentation	1.32760102
43	MP0004147_increased_porphyrin_level	1.31993042
44	MP0004145_abnormal_muscle_electrophysio	1.28616174
45	MP0000015_abnormal_ear_pigmentation	1.24622501
46	MP0001919_abnormal_reproductive_system	1.24502859
47	MP0009697_abnormal_copulation	1.24348174
48	MP0002751_abnormal_autonomic_nervous	1.15986693
49	MP0009745_abnormal_behavioral_response	1.12660553
50	MP0005075_abnormal_melanosome_morpholog	1.12284805
51	MP0010386_abnormal_urinary_bladder	1.11379852
52	MP0004924_abnormal_behavior	1.10078317
53	MP0005386_behavior/neurological_phenoty	1.10078317
54	MP0005084_abnormal_gallbladder_morpholo	1.09533546
55	MP0000647_abnormal_sebaceous_gland	1.08713793
56	MP0006276_abnormal_autonomic_nervous	1.07999171
57	MP0008058_abnormal_DNA_repair	1.05452234
58	MP0003567_abnormal_fetal_cardiomyocyte	1.02699764
59	MP0001324_abnormal_eye_pigmentation	1.02331451
60	MP0002736_abnormal_nociception_after	1.01407189
61	MP0001293_anophthalmia	1.01278178
62	MP0001929_abnormal_gametogenesis	1.01140956
63	MP0005195_abnormal_posterior_eye	0.99030531
64	MP0004885_abnormal_endolymph	0.98744606
65	MP0008995_early_reproductive_senescence	0.98469071
66	MP0002272_abnormal_nervous_system	0.98468433
67	MP0001501_abnormal_sleep_pattern	0.97289566
68	MP0003252_abnormal_bile_duct	0.97287810
69	MP0003121_genomic_imprinting	0.96334057
70	MP0008961_abnormal_basal_metabolism	0.96054083
71	MP0004742_abnormal_vestibular_system	0.93104619
72	MP0008775_abnormal_heart_ventricle	0.93026399
73	MP0004215_abnormal_myocardial_fiber	0.91565055
74	MP0003698_abnormal_male_reproductive	0.91156158
75	MP0005410_abnormal_fertilization	0.91048428
76	MP0002277_abnormal_respiratory_mucosa	0.90878067
77	MP0003937_abnormal_limbs/digits/tail_de	0.90309576
78	MP0003693_abnormal_embryo_hatching	0.89914798
79	MP0002210_abnormal_sex_determination	0.89862397
80	MP0002735_abnormal_chemical_nociception	0.89796810
81	MP0002254_reproductive_system_inflammat	0.88913155
82	MP0002234_abnormal_pharynx_morphology	0.88449882
83	MP0005365_abnormal_bile_salt	0.88366148
84	MP0010329_abnormal_lipoprotein_level	0.86870559
85	MP0005391_vision/eye_phenotype	0.86206078
86	MP0002557_abnormal_social/conspecific_i	0.85681429
87	MP0010094_abnormal_chromosome_stability	0.85424892
88	MP0000538_abnormal_urinary_bladder	0.84995351
89	MP0003936_abnormal_reproductive_system	0.83444166
90	MP0001502_abnormal_circadian_rhythm	0.82421229
91	MP0003119_abnormal_digestive_system	0.81866821
92	MP0000653_abnormal_sex_gland	0.81360831
93	MP0005187_abnormal_penis_morphology	0.79847391
94	MP0005332_abnormal_amino_acid	0.79364823
95	MP0001119_abnormal_female_reproductive	0.79300937
96	MP0004484_altered_response_of	0.78340229
97	MP0001145_abnormal_male_reproductive	0.77204787
98	MP0003137_abnormal_impulse_conducting	0.75300546
99	MP0003283_abnormal_digestive_organ	0.74945403
100	MP0010678_abnormal_skin_adnexa	0.74502648

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.89371107
2	Pancreatic fibrosis (HP:0100732)	4.30321905
3	True hermaphroditism (HP:0010459)	3.97934661
4	Chronic hepatic failure (HP:0100626)	3.97340152
5	Molar tooth sign on MRI (HP:0002419)	3.96312455
6	Abnormality of midbrain morphology (HP:0002418)	3.96312455
7	Hyperventilation (HP:0002883)	3.91919314
8	Nephronophthisis (HP:0000090)	3.68831201
9	Congenital stationary night blindness (HP:0007642)	3.56872695
10	Abnormality of the renal cortex (HP:0011035)	3.45727749
11	Abnormality of the renal medulla (HP:0100957)	3.40968745
12	Type II lissencephaly (HP:0007260)	3.39453979
13	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.20832270
14	Abnormality of alanine metabolism (HP:0010916)	3.20832270
15	Hyperalaninemia (HP:0003348)	3.20832270
16	Attenuation of retinal blood vessels (HP:0007843)	3.09386844
17	Cerebellar dysplasia (HP:0007033)	3.02315585
18	Tubular atrophy (HP:0000092)	3.00727701
19	Cystic liver disease (HP:0006706)	2.92569012
20	Medial flaring of the eyebrow (HP:0010747)	2.86619902
21	Abnormal drinking behavior (HP:0030082)	2.79162821
22	Polydipsia (HP:0001959)	2.79162821
23	Gaze-evoked nystagmus (HP:0000640)	2.68376290
24	Bile duct proliferation (HP:0001408)	2.67934560
25	Abnormal biliary tract physiology (HP:0012439)	2.67934560
26	Pendular nystagmus (HP:0012043)	2.59180494
27	Abolished electroretinogram (ERG) (HP:0000550)	2.53339073
28	Chorioretinal atrophy (HP:0000533)	2.46751776
29	Decreased central vision (HP:0007663)	2.46368896
30	Furrowed tongue (HP:0000221)	2.40918414
31	Sclerocornea (HP:0000647)	2.37746727
32	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.36773721
33	Progressive inability to walk (HP:0002505)	2.36556953
34	Congenital hepatic fibrosis (HP:0002612)	2.35350101
35	Methylmalonic aciduria (HP:0012120)	2.34076715
36	Large for gestational age (HP:0001520)	2.33793812
37	Hypothermia (HP:0002045)	2.33788890
38	Patellar aplasia (HP:0006443)	2.32309198
39	Renal cortical cysts (HP:0000803)	2.26403847
40	Lissencephaly (HP:0001339)	2.25020606
41	Birth length less than 3rd percentile (HP:0003561)	2.24795924
42	Abnormality of the pons (HP:0007361)	2.24536842
43	Inability to walk (HP:0002540)	2.23435692
44	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.21216930
45	Congenital, generalized hypertrichosis (HP:0004540)	2.20354391
46	Anencephaly (HP:0002323)	2.19327125
47	Male pseudohermaphroditism (HP:0000037)	2.18555381
48	Hypoplasia of the pons (HP:0012110)	2.17703040
49	Genetic anticipation (HP:0003743)	2.16207588
50	Congenital primary aphakia (HP:0007707)	2.15239666
51	Aplasia/Hypoplasia of the patella (HP:0006498)	2.14545768
52	Polyuria (HP:0000103)	2.12853843
53	Stomach cancer (HP:0012126)	2.12068420
54	Gait imbalance (HP:0002141)	2.11279903
55	Aplasia/Hypoplasia of the uvula (HP:0010293)	2.09249461
56	Fair hair (HP:0002286)	2.08182869
57	Abnormal rod and cone electroretinograms (HP:0008323)	2.07558616
58	Protruding tongue (HP:0010808)	2.04060061
59	Increased corneal curvature (HP:0100692)	1.98311680
60	Keratoconus (HP:0000563)	1.98311680
61	Nephrogenic diabetes insipidus (HP:0009806)	1.98250443
62	Colon cancer (HP:0003003)	1.95317772
63	Abnormality of the renal collecting system (HP:0004742)	1.94685690
64	Decreased circulating renin level (HP:0003351)	1.94684546
65	Bony spicule pigmentary retinopathy (HP:0007737)	1.92897704
66	Duplicated collecting system (HP:0000081)	1.92455524
67	Abnormality of the ileum (HP:0001549)	1.91768888
68	Genital tract atresia (HP:0001827)	1.90538065
69	Oligodactyly (hands) (HP:0001180)	1.89618667
70	Dandy-Walker malformation (HP:0001305)	1.89515504
71	Clubbing of toes (HP:0100760)	1.88670747
72	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.88287332
73	Postaxial foot polydactyly (HP:0001830)	1.88020857
74	Vaginal atresia (HP:0000148)	1.87460219
75	Broad-based gait (HP:0002136)	1.84334103
76	Meckel diverticulum (HP:0002245)	1.84252158
77	Bilateral microphthalmos (HP:0007633)	1.84109058
78	Absent thumb (HP:0009777)	1.82842141
79	Absent rod-and cone-mediated responses on ERG (HP:0007688)	1.78784218
80	Rib fusion (HP:0000902)	1.77674176
81	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.76977767
82	Tachypnea (HP:0002789)	1.76291733
83	Oligohydramnios (HP:0001562)	1.75842965
84	Astigmatism (HP:0000483)	1.74622393
85	Optic nerve hypoplasia (HP:0000609)	1.73741943
86	Hypoplastic iliac wings (HP:0002866)	1.73674588
87	Hypomagnesemia (HP:0002917)	1.73665027
88	Sloping forehead (HP:0000340)	1.73145290
89	Progressive cerebellar ataxia (HP:0002073)	1.71968843
90	Hyperglycinuria (HP:0003108)	1.71786488
91	Poor coordination (HP:0002370)	1.71119074
92	Abnormal urine output (HP:0012590)	1.70818664
93	Occipital encephalocele (HP:0002085)	1.70147172
94	Preaxial hand polydactyly (HP:0001177)	1.68156534
95	Abnormality of chromosome stability (HP:0003220)	1.66457008
96	Methylmalonic acidemia (HP:0002912)	1.66089635
97	Febrile seizures (HP:0002373)	1.65275179
98	Intestinal atresia (HP:0011100)	1.63429046
99	Partial agenesis of the corpus callosum (HP:0001338)	1.63068551
100	Severe muscular hypotonia (HP:0006829)	1.61952260

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.97599550
2	BMPR1B	3.31097846
3	ZAK	3.22350088
4	ACVR1B	3.10313195
5	TLK1	2.88615943
6	MAP3K4	2.53512617
7	WNK4	2.49578950
8	ADRBK2	2.43657193
9	MAP4K2	2.36476271
10	INSRR	2.29418552
11	TAOK3	2.21606764
12	NUAK1	2.17061673
13	WNK3	2.06555300
14	GRK1	1.92736834
15	MKNK2	1.69904473
16	OXSR1	1.69213335
17	PINK1	1.57212286
18	MAPK15	1.51011370
19	STK39	1.50078388
20	TXK	1.40051487
21	DAPK2	1.33742331
22	TNIK	1.28501022
23	TGFBR1	1.23882207
24	PNCK	1.19916764
25	CASK	1.19796653
26	MAPK13	1.16160565
27	STK38L	1.09803372
28	VRK1	1.08512747
29	PAK3	1.07931240
30	ADRBK1	1.06750388
31	MAP2K7	1.05025567
32	NLK	1.04880201
33	MUSK	0.97442279
34	OBSCN	0.96256496
35	MKNK1	0.95684249
36	TRIM28	0.92987932
37	AKT3	0.91579691
38	FGFR2	0.90325496
39	PLK4	0.88172290
40	EIF2AK3	0.83067331
41	BRSK2	0.82457847
42	CAMKK2	0.81998128
43	CDK8	0.81689039
44	STK3	0.81530931
45	PIK3CA	0.80753811
46	TEC	0.80246578
47	MST4	0.75661211
48	CHUK	0.75612848
49	PLK2	0.75054676
50	PRKCE	0.74711581
51	NME1	0.72290320
52	RPS6KA5	0.69934428
53	IKBKB	0.69035291
54	CSNK1G1	0.69024709
55	BCR	0.68918678
56	MAP2K6	0.64701908
57	DYRK3	0.63831154
58	CSNK1A1L	0.62244119
59	PLK3	0.62211136
60	PRKCG	0.61859694
61	ATR	0.61336137
62	WEE1	0.60457583
63	CHEK2	0.59799319
64	STK11	0.59664642
65	MAPKAPK3	0.57818146
66	TIE1	0.53407391
67	TRPM7	0.53053936
68	FLT3	0.52825122
69	WNK1	0.51849563
70	KIT	0.50893547
71	IRAK1	0.50683780
72	NEK2	0.50506342
73	PRKAA2	0.48421357
74	CSNK1G2	0.47899800
75	PTK2B	0.46745611
76	MAP2K4	0.46468340
77	SGK2	0.46434958
78	DYRK2	0.46357244
79	CSNK1G3	0.45207228
80	ERBB3	0.44768135
81	STK16	0.44280838
82	RPS6KA6	0.43544973
83	PLK1	0.43129599
84	BRD4	0.42875511
85	ATM	0.41985694
86	TAF1	0.41340808
87	PRKCQ	0.41307579
88	PIK3CG	0.40257687
89	EPHA3	0.39950002
90	PHKG1	0.38575415
91	PHKG2	0.38575415
92	CDC7	0.38479127
93	CSNK1D	0.37788110
94	PRKCI	0.37438616
95	CDK19	0.37252261
96	SRPK1	0.35872622
97	PRKAA1	0.35448512
98	MELK	0.34246126
99	PRKACA	0.33959418
100	MAP3K7	0.33352734

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nitrogen metabolism_Homo sapiens_hsa00910	2.90028278
2	Linoleic acid metabolism_Homo sapiens_hsa00591	2.89782818
3	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.80643541
4	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.67973372
5	Homologous recombination_Homo sapiens_hsa03440	2.64391286
6	Fanconi anemia pathway_Homo sapiens_hsa03460	2.48523961
7	Phototransduction_Homo sapiens_hsa04744	2.40418572
8	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.30661633
9	RNA polymerase_Homo sapiens_hsa03020	2.24111428
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.23927020
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.22676598
12	Ether lipid metabolism_Homo sapiens_hsa00565	2.14132214
13	Basal transcription factors_Homo sapiens_hsa03022	2.06024491
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	2.03705650
15	Caffeine metabolism_Homo sapiens_hsa00232	1.99459676
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.94690490
17	Oxidative phosphorylation_Homo sapiens_hsa00190	1.84925731
18	Selenocompound metabolism_Homo sapiens_hsa00450	1.84679451
19	Butanoate metabolism_Homo sapiens_hsa00650	1.77851650
20	Tryptophan metabolism_Homo sapiens_hsa00380	1.76916386
21	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.75800867
22	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.64312289
23	Propanoate metabolism_Homo sapiens_hsa00640	1.58354613
24	RNA degradation_Homo sapiens_hsa03018	1.54956947
25	ABC transporters_Homo sapiens_hsa02010	1.54840116
26	Protein export_Homo sapiens_hsa03060	1.51232736
27	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.48189242
28	One carbon pool by folate_Homo sapiens_hsa00670	1.42684874
29	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.39780883
30	Taste transduction_Homo sapiens_hsa04742	1.33688328
31	Non-homologous end-joining_Homo sapiens_hsa03450	1.33683142
32	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.32700608
33	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.32339328
34	Nicotine addiction_Homo sapiens_hsa05033	1.31773907
35	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.30107702
36	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.28539244
37	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.25165618
38	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.20232552
39	Parkinsons disease_Homo sapiens_hsa05012	1.16833068
40	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.05423555
41	Huntingtons disease_Homo sapiens_hsa05016	1.05368725
42	Peroxisome_Homo sapiens_hsa04146	1.04004748
43	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.99167778
44	Fat digestion and absorption_Homo sapiens_hsa04975	0.96192836
45	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.95892506
46	Chemical carcinogenesis_Homo sapiens_hsa05204	0.95125811
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.94215781
48	Retinol metabolism_Homo sapiens_hsa00830	0.90222304
49	Regulation of autophagy_Homo sapiens_hsa04140	0.88256720
50	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.87426138
51	Olfactory transduction_Homo sapiens_hsa04740	0.87161874
52	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.86530709
53	Circadian rhythm_Homo sapiens_hsa04710	0.85821859
54	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.84347124
55	Purine metabolism_Homo sapiens_hsa00230	0.82030285
56	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.80233524
57	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.76986755
58	Alzheimers disease_Homo sapiens_hsa05010	0.73744386
59	Cardiac muscle contraction_Homo sapiens_hsa04260	0.69974735
60	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.65742659
61	Mismatch repair_Homo sapiens_hsa03430	0.65084882
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.65043488
63	Sulfur relay system_Homo sapiens_hsa04122	0.64914439
64	Morphine addiction_Homo sapiens_hsa05032	0.63458453
65	Primary immunodeficiency_Homo sapiens_hsa05340	0.60778824
66	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.60084092
67	Mineral absorption_Homo sapiens_hsa04978	0.59811188
68	Metabolic pathways_Homo sapiens_hsa01100	0.59492453
69	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.59461436
70	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.57234783
71	Glycerolipid metabolism_Homo sapiens_hsa00561	0.57078732
72	Nucleotide excision repair_Homo sapiens_hsa03420	0.56994383
73	Lysine degradation_Homo sapiens_hsa00310	0.56123846
74	Serotonergic synapse_Homo sapiens_hsa04726	0.54312860
75	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53383023
76	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.51477653
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.51208406
78	RNA transport_Homo sapiens_hsa03013	0.49491266
79	Histidine metabolism_Homo sapiens_hsa00340	0.49339149
80	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.48890373
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.45557332
82	Asthma_Homo sapiens_hsa05310	0.45476070
83	Calcium signaling pathway_Homo sapiens_hsa04020	0.44603058
84	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.42770697
85	Collecting duct acid secretion_Homo sapiens_hsa04966	0.42429930
86	Ribosome_Homo sapiens_hsa03010	0.40705834
87	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.38943124
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.38388039
89	Basal cell carcinoma_Homo sapiens_hsa05217	0.38026774
90	Glutamatergic synapse_Homo sapiens_hsa04724	0.37028787
91	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.36729195
92	Proteasome_Homo sapiens_hsa03050	0.35875753
93	Insulin secretion_Homo sapiens_hsa04911	0.35842877
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.35685028
95	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.34088983
96	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.33468644
97	Fatty acid degradation_Homo sapiens_hsa00071	0.33226237
98	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.32443951
99	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.32268659
100	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.32128227

MFSD4B

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »