MFSD5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcription from mitochondrial promoter (GO:0006390)8.06589240
2proline metabolic process (GO:0006560)7.45211311
3DNA deamination (GO:0045006)7.44614369
4embryonic process involved in female pregnancy (GO:0060136)7.11148898
5replication fork processing (GO:0031297)7.00724885
6regulation of integrin activation (GO:0033623)6.58799099
7positive regulation of protein homooligomerization (GO:0032464)6.55574648
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.91630436
9establishment of apical/basal cell polarity (GO:0035089)5.67752026
10oxidative demethylation (GO:0070989)5.57445058
11regulation of protein homooligomerization (GO:0032462)5.49862992
12mitochondrial DNA metabolic process (GO:0032042)5.12023462
13mitotic G1 DNA damage checkpoint (GO:0031571)5.00097350
14somatic diversification of immune receptors via somatic mutation (GO:0002566)4.97131058
15somatic hypermutation of immunoglobulin genes (GO:0016446)4.97131058
16formation of translation preinitiation complex (GO:0001731)4.95748851
17establishment or maintenance of monopolar cell polarity (GO:0061339)4.82367608
18establishment of monopolar cell polarity (GO:0061162)4.82367608
19viral mRNA export from host cell nucleus (GO:0046784)4.79210649
20negative regulation of JAK-STAT cascade (GO:0046426)4.76499265
21DNA strand renaturation (GO:0000733)4.63353480
22poly(A)+ mRNA export from nucleus (GO:0016973)4.54200212
23mitotic G1/S transition checkpoint (GO:0044819)4.45718306
24establishment of protein localization to mitochondrial membrane (GO:0090151)4.39026621
25G1 DNA damage checkpoint (GO:0044783)4.38807871
26protein maturation by protein folding (GO:0022417)4.31289374
27regulation of translational fidelity (GO:0006450)4.28188146
28mRNA cleavage (GO:0006379)4.28065186
29embryonic placenta development (GO:0001892)4.26521689
30negative regulation of cell cycle arrest (GO:0071157)4.24598037
31negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)4.23789755
32cellular response to zinc ion (GO:0071294)4.23105858
33cellular response to ATP (GO:0071318)4.01837891
34positive regulation of protein oligomerization (GO:0032461)4.00790317
35telomere maintenance via semi-conservative replication (GO:0032201)3.98426766
36negative regulation of Ras GTPase activity (GO:0034261)3.95214495
37base-excision repair (GO:0006284)3.93943350
38DNA integration (GO:0015074)3.87365072
39negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.85915172
40mitochondrial RNA metabolic process (GO:0000959)3.76083913
41spliceosomal tri-snRNP complex assembly (GO:0000244)3.73641525
42glutamine family amino acid biosynthetic process (GO:0009084)3.70842145
43positive regulation of developmental pigmentation (GO:0048087)3.69204892
44GDP-mannose metabolic process (GO:0019673)3.63944356
45embryonic camera-type eye development (GO:0031076)3.62593946
46glial cell migration (GO:0008347)3.59007964
47pinocytosis (GO:0006907)3.56344432
48face development (GO:0060324)3.56190595
49regulation of protein oligomerization (GO:0032459)3.55816120
50apoptotic process involved in morphogenesis (GO:0060561)3.55421303
51nucleotide-excision repair, DNA gap filling (GO:0006297)3.50702490
52mitotic nuclear envelope reassembly (GO:0007084)3.49967273
53nuclear envelope reassembly (GO:0031468)3.49967273
54negative regulation of protein oligomerization (GO:0032460)3.49356934
55histone H4-K12 acetylation (GO:0043983)3.46256117
56positive regulation of mitotic sister chromatid separation (GO:1901970)3.46080646
57positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.46080646
58positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.46080646
59negative regulation of fatty acid biosynthetic process (GO:0045717)3.45603826
60pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.45409707
61non-recombinational repair (GO:0000726)3.45043010
62double-strand break repair via nonhomologous end joining (GO:0006303)3.45043010
63maturation of 5.8S rRNA (GO:0000460)3.42276020
64DNA double-strand break processing (GO:0000729)3.37949311
65dosage compensation (GO:0007549)3.37641240
66negative regulation of mRNA processing (GO:0050686)3.36709902
67regulation of double-strand break repair via homologous recombination (GO:0010569)3.34937980
68trophectodermal cell differentiation (GO:0001829)3.33962287
69base-excision repair, AP site formation (GO:0006285)3.33660671
70regulation of sister chromatid cohesion (GO:0007063)3.31313046
71positive regulation by host of viral transcription (GO:0043923)3.30619901
72termination of RNA polymerase II transcription (GO:0006369)3.28539508
73deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.27945753
74anatomical structure regression (GO:0060033)3.27826196
75DNA strand elongation involved in DNA replication (GO:0006271)3.27085946
76regulation of RNA export from nucleus (GO:0046831)3.24125963
77antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.22817045
78regulation of gene silencing by miRNA (GO:0060964)3.22559413
79regulation of gene silencing by RNA (GO:0060966)3.22559413
80regulation of posttranscriptional gene silencing (GO:0060147)3.22559413
81amyloid precursor protein catabolic process (GO:0042987)3.21465681
82labyrinthine layer development (GO:0060711)3.21464075
83telomere maintenance via recombination (GO:0000722)3.21361523
84negative regulation of tumor necrosis factor production (GO:0032720)3.20678768
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.18478179
86COPI coating of Golgi vesicle (GO:0048205)3.16908638
87Golgi transport vesicle coating (GO:0048200)3.16908638
88meiotic chromosome segregation (GO:0045132)3.16386243
89amino sugar catabolic process (GO:0046348)3.16160728
90positive regulation of monocyte chemotaxis (GO:0090026)3.12538329
91regulation of early endosome to late endosome transport (GO:2000641)3.12280056
92NIK/NF-kappaB signaling (GO:0038061)3.10311822
93negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)3.09626793
94convergent extension (GO:0060026)3.09518836
95pentose-phosphate shunt (GO:0006098)3.07051665
96regulation of podosome assembly (GO:0071801)3.06673576
97positive regulation of DNA repair (GO:0045739)3.06048046
98DNA strand elongation (GO:0022616)3.03793720
99UV protection (GO:0009650)3.01553346
100negative regulation of RNA splicing (GO:0033119)3.00859237
101activation of Rac GTPase activity (GO:0032863)2.99997971
102kinetochore assembly (GO:0051382)2.98597847
103regulation of cell size (GO:0008361)2.98046205
104regulation of double-strand break repair (GO:2000779)2.97299796
105nodal signaling pathway (GO:0038092)2.97204858
106membrane invagination (GO:0010324)2.96944126
107positive regulation of chromosome segregation (GO:0051984)2.96555968
108proteasome assembly (GO:0043248)2.95346897
109regulation of superoxide anion generation (GO:0032928)2.92652785
110protein localization to endosome (GO:0036010)2.91204642
111barbed-end actin filament capping (GO:0051016)2.90242856
112DNA topological change (GO:0006265)2.88403343
113negative regulation of stress fiber assembly (GO:0051497)2.86741109
114positive regulation of interleukin-8 secretion (GO:2000484)2.86364427
115negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.86266216
116positive regulation of T cell apoptotic process (GO:0070234)2.84721871
117positive regulation of receptor recycling (GO:0001921)2.84446217
118regulation of hippo signaling (GO:0035330)2.83956980
119autophagic vacuole fusion (GO:0000046)2.82876579
120pyrimidine-containing compound salvage (GO:0008655)2.82816217
121pyrimidine nucleoside salvage (GO:0043097)2.82816217
122regulation of cellular amino acid metabolic process (GO:0006521)2.72904552
123NADPH regeneration (GO:0006740)2.72093945
124negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.68127092
125chaperone mediated protein folding requiring cofactor (GO:0051085)2.67307037
126negative regulation of nitric oxide biosynthetic process (GO:0045019)2.66002480
127negative regulation of interleukin-12 production (GO:0032695)2.65086059
128cellular response to arsenic-containing substance (GO:0071243)2.62964246
129regulation of monocyte chemotaxis (GO:0090025)2.62103339
130negative regulation of ligase activity (GO:0051352)2.59481183
131negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.59481183
132response to peptidoglycan (GO:0032494)2.57145219
133endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.54580450
134glucose catabolic process (GO:0006007)2.54367483
135DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.52522646
136positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.49715950
137immunoglobulin mediated immune response (GO:0016064)2.49490782
138antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.48767807
139neutrophil activation involved in immune response (GO:0002283)2.48637774
140hyaluronan catabolic process (GO:0030214)2.47446493
141response to interferon-beta (GO:0035456)2.47353085
142regulation of mononuclear cell migration (GO:0071675)2.46738646
143intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.45182660
144signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.45182660
145heme biosynthetic process (GO:0006783)2.44630479
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.41521440
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.40341331
148lipopolysaccharide biosynthetic process (GO:0009103)2.40002881
149regulation of vitamin D biosynthetic process (GO:0060556)2.39600645
150pentose metabolic process (GO:0019321)2.39271570
151signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39218380
152signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39218380
153signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39218380
154myeloid dendritic cell differentiation (GO:0043011)2.39199102
155lipopolysaccharide metabolic process (GO:0008653)2.38201884
156morphogenesis of an endothelium (GO:0003159)2.36418025
157endothelial tube morphogenesis (GO:0061154)2.36418025
158nucleotide salvage (GO:0043173)2.35557236
159regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.34817397
160signal transduction involved in DNA integrity checkpoint (GO:0072401)2.34353779
161signal transduction involved in DNA damage checkpoint (GO:0072422)2.34353779
162negative regulation of myeloid cell apoptotic process (GO:0033033)2.31512206
163myeloid dendritic cell activation (GO:0001773)2.31318500
164rRNA modification (GO:0000154)2.30294571
165positive regulation of Cdc42 GTPase activity (GO:0043089)2.29503604
166leukocyte apoptotic process (GO:0071887)2.28935849
167anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.28500980
168lipoxygenase pathway (GO:0019372)2.28004293
169organelle membrane fusion (GO:0090174)2.27366358
170heme metabolic process (GO:0042168)2.27114208
171negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.24204720
172signal transduction involved in cell cycle checkpoint (GO:0072395)2.24070886
173positive regulation of lymphocyte migration (GO:2000403)2.23737789
174modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.22662751
175positive regulation by organism of defense response of other organism involved in symbiotic interact2.22662751
176modulation by symbiont of host immune response (GO:0052553)2.22662751
177positive regulation by symbiont of host defense response (GO:0052509)2.22662751
178modulation by symbiont of host defense response (GO:0052031)2.22662751
179modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.22662751
180fibril organization (GO:0097435)2.22658356
181chaperone-mediated protein transport (GO:0072321)2.22326130
182antigen processing and presentation of endogenous antigen (GO:0019883)2.21386772
183negative regulation of mitochondrion organization (GO:0010823)2.21380275
184regulation of superoxide metabolic process (GO:0090322)2.20025079
185protein targeting to mitochondrion (GO:0006626)2.19586646
186positive regulation of chemokine biosynthetic process (GO:0045080)2.18830802
187negative regulation of interleukin-17 production (GO:0032700)2.18679472
188leukocyte aggregation (GO:0070486)2.17836382
189regulation of T cell migration (GO:2000404)2.16521217
190positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.16511952
191N-acetylneuraminate metabolic process (GO:0006054)2.15596157
192extracellular fibril organization (GO:0043206)2.14976943
193antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.14818603
194proline biosynthetic process (GO:0006561)10.0219849

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human3.37928567
2MYC_18555785_ChIP-Seq_MESCs_Mouse2.92309744
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.84051071
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.75318963
5KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.69664553
6KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.69664553
7KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.69664553
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.67609078
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54499795
10VDR_21846776_ChIP-Seq_THP-1_Human2.53464909
11ELF1_17652178_ChIP-ChIP_JURKAT_Human2.49634450
12E2F7_22180533_ChIP-Seq_HELA_Human2.35290089
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29861344
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29834126
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.29537958
16KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.20517002
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.19527720
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.18834395
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16575725
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.10575764
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.95546976
22NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91819230
23* LXR_22292898_ChIP-Seq_THP-1_Human1.90741976
24SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.90080537
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.89248166
26KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87454952
27POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.85298334
28MYC_22102868_ChIP-Seq_BL_Human1.84282925
29MYC_19030024_ChIP-ChIP_MESCs_Mouse1.84190028
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83289997
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.82003074
32IRF8_22096565_ChIP-ChIP_GC-B_Human1.78107593
33JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77372885
34RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74548724
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74156858
36NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.71819678
37FOXM1_23109430_ChIP-Seq_U2OS_Human1.70992043
38CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69471553
39SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.66209164
40POU5F1_16518401_ChIP-PET_MESCs_Mouse1.64787549
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.63656217
42* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.63536077
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.62685178
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.60594517
45GABP_17652178_ChIP-ChIP_JURKAT_Human1.59666148
46* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.59434042
47KLF4_18555785_ChIP-Seq_MESCs_Mouse1.58257052
48ZNF263_19887448_ChIP-Seq_K562_Human1.57171215
49CREB1_15753290_ChIP-ChIP_HEK293T_Human1.56178258
50* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.55390394
51NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55307288
52STAT4_19710469_ChIP-ChIP_TH1__Mouse1.54521768
53TP63_17297297_ChIP-ChIP_HaCaT_Human1.51988766
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.50725955
55TET1_21451524_ChIP-Seq_MESCs_Mouse1.50204945
56E2F1_18555785_ChIP-Seq_MESCs_Mouse1.49928161
57* RACK7_27058665_Chip-Seq_MCF-7_Human1.49086494
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.48796867
59NANOG_21062744_ChIP-ChIP_HESCs_Human1.48524159
60NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.47862551
61RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47719822
62SPI1_23547873_ChIP-Seq_NB4_Human1.47475152
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.46667492
64IRF8_21731497_ChIP-ChIP_J774_Mouse1.46457647
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.45393609
66ERG_21242973_ChIP-ChIP_JURKAT_Human1.45175908
67FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.42810042
68CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42134464
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40866740
70* ELK3_25401928_ChIP-Seq_HUVEC_Human1.39520567
71THAP11_20581084_ChIP-Seq_MESCs_Mouse1.38686648
72* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.38583672
73YY1_21170310_ChIP-Seq_MESCs_Mouse1.38179517
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37518283
75GABP_19822575_ChIP-Seq_HepG2_Human1.36882305
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36324174
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.35865097
78* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35005330
79NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32169147
80MAF_26560356_Chip-Seq_TH1_Human1.31974507
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31963627
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.31555962
83DCP1A_22483619_ChIP-Seq_HELA_Human1.31435510
84SRF_21415370_ChIP-Seq_HL-1_Mouse1.31395027
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29538306
86KDM2B_26808549_Chip-Seq_DND41_Human1.28439154
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.28266993
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.27860716
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27808943
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.27577220
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27238166
92EGR1_19374776_ChIP-ChIP_THP-1_Human1.27211670
93SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26669518
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26071865
95TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25953058
96POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25711956
97RUNX1_22412390_ChIP-Seq_EML_Mouse1.24743698
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24358729
99HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.24188359
100BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23749389
101CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23144034
102POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.23073629
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.22307310
104EST1_17652178_ChIP-ChIP_JURKAT_Human1.22156035
105MAF_26560356_Chip-Seq_TH2_Human1.22057310
106RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.22038611
107XRN2_22483619_ChIP-Seq_HELA_Human1.22030705
108UTX_26944678_Chip-Seq_JUKART_Human1.21328622
109ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20535904
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.19691354
111* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19064800
112SOX2_18692474_ChIP-Seq_MEFs_Mouse1.17979818
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.17137810
114* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.16995859
115EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16720362
116OCT4_18692474_ChIP-Seq_MEFs_Mouse1.16112015
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.16002770
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15203729
119IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.14912789
120CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14642518
121POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14163781
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.12764207
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.12710678
124* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.12637025
125* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11710938
126PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10999076
127TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10046468
128ZFX_18555785_ChIP-Seq_MESCs_Mouse1.09607566
129TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09347925
130CTCF_21964334_ChIP-Seq_BJAB-B_Human1.09156542
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.08060086
132ATF3_27146783_Chip-Seq_COLON_Human1.07892899
133BCL6_27268052_Chip-Seq_Bcells_Human1.07716873
134ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07691727
135SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07013857
136ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06823380
137* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.06205033
138* ETS1_21867929_ChIP-Seq_TH2_Mouse1.06128448
139ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.06009010
140SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.05911233
141DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05753969
142SA1_27219007_Chip-Seq_ERYTHROID_Human1.05748005
143EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05434355
144CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05279693
145GATA1_22383799_ChIP-Seq_G1ME_Mouse1.05063804
146BCOR_27268052_Chip-Seq_Bcells_Human1.05013130
147NANOG_18692474_ChIP-Seq_MESCs_Mouse1.04136800
148FOXP3_21729870_ChIP-Seq_TREG_Human1.04112950
149TTF2_22483619_ChIP-Seq_HELA_Human1.04105380
150* RARB_24833708_ChIP-Seq_LIVER_Mouse1.03484203
151* RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02988380
152* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.02604143
153* KDM5A_27292631_Chip-Seq_BREAST_Human1.02251085
154SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02078511
155PHF8_20622854_ChIP-Seq_HELA_Human1.02069472
156SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.01836036
157* TFEB_21752829_ChIP-Seq_HELA_Human1.01147453
158P300_27058665_Chip-Seq_ZR-75-30cells_Human0.99294797
159VDR_24763502_ChIP-Seq_THP-1_Human0.98517903

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.68339447
2MP0009278_abnormal_bone_marrow4.60472416
3MP0005171_absent_coat_pigmentation4.13029013
4MP0010030_abnormal_orbit_morphology3.57637013
5MP0003191_abnormal_cellular_cholesterol2.92072926
6MP0004233_abnormal_muscle_weight2.90111311
7MP0002009_preneoplasia2.79292823
8MP0003436_decreased_susceptibility_to2.68519223
9MP0001545_abnormal_hematopoietic_system2.64858128
10MP0005397_hematopoietic_system_phenotyp2.64858128
11MP0003806_abnormal_nucleotide_metabolis2.56434378
12MP0002148_abnormal_hypersensitivity_rea2.49915301
13MP0001835_abnormal_antigen_presentation2.36216531
14MP0008260_abnormal_autophagy2.31243622
15MP0004957_abnormal_blastocyst_morpholog2.28284717
16MP0002877_abnormal_melanocyte_morpholog2.24791017
17MP0010094_abnormal_chromosome_stability2.23060645
18MP0005058_abnormal_lysosome_morphology2.18952506
19MP0003303_peritoneal_inflammation2.17710396
20MP0009785_altered_susceptibility_to2.15879997
21MP0003453_abnormal_keratinocyte_physiol2.04556966
22MP0010352_gastrointestinal_tract_polyps1.99790921
23MP0008995_early_reproductive_senescence1.94291039
24MP0005000_abnormal_immune_tolerance1.93430881
25MP0008438_abnormal_cutaneous_collagen1.93424721
26MP0005076_abnormal_cell_differentiation1.93285581
27MP0005025_abnormal_response_to1.92232572
28MP0002419_abnormal_innate_immunity1.90858286
29MP0003786_premature_aging1.90285845
30MP0005174_abnormal_tail_pigmentation1.87244747
31MP0003111_abnormal_nucleus_morphology1.86646017
32MP0003186_abnormal_redox_activity1.83228217
33MP0003283_abnormal_digestive_organ1.81883385
34MP0001790_abnormal_immune_system1.81534080
35MP0005387_immune_system_phenotype1.81534080
36MP0005671_abnormal_response_to1.79706552
37MP0003172_abnormal_lysosome_physiology1.73520701
38MP0003693_abnormal_embryo_hatching1.72488006
39MP0003890_abnormal_embryonic-extraembry1.71120914
40MP0000490_abnormal_crypts_of1.71048861
41MP0006054_spinal_hemorrhage1.69644572
42MP0000372_irregular_coat_pigmentation1.69605177
43MP0005464_abnormal_platelet_physiology1.66704123
44MP0002086_abnormal_extraembryonic_tissu1.63978634
45MP0002282_abnormal_trachea_morphology1.62158754
46MP0002653_abnormal_ependyma_morphology1.61888207
47MP0004133_heterotaxia1.61283388
48MP0002796_impaired_skin_barrier1.59264910
49MP0003724_increased_susceptibility_to1.59192269
50MP0003119_abnormal_digestive_system1.59173122
51MP0001542_abnormal_bone_strength1.57466930
52MP0008932_abnormal_embryonic_tissue1.56984228
53MP0001533_abnormal_skeleton_physiology1.56512969
54MP0002723_abnormal_immune_serum1.55349903
55MP0000343_altered_response_to1.55341335
56MP0002452_abnormal_antigen_presenting1.53654967
57MP0000858_altered_metastatic_potential1.52554390
58MP0001697_abnormal_embryo_size1.52393969
59MP0005451_abnormal_body_composition1.51460282
60MP0002420_abnormal_adaptive_immunity1.49368775
61MP0001853_heart_inflammation1.48772462
62MP0001819_abnormal_immune_cell1.47239392
63MP0002249_abnormal_larynx_morphology1.47223475
64MP0001293_anophthalmia1.44564714
65MP0003705_abnormal_hypodermis_morpholog1.43650597
66MP0003077_abnormal_cell_cycle1.43384633
67MP0002084_abnormal_developmental_patter1.41297454
68MP0000371_diluted_coat_color1.38316025
69MP0001800_abnormal_humoral_immune1.37399173
70MP0004197_abnormal_fetal_growth/weight/1.37281038
71MP0008058_abnormal_DNA_repair1.37264684
72MP0000579_abnormal_nail_morphology1.37185687
73MP0003567_abnormal_fetal_cardiomyocyte1.34813241
74MP0009333_abnormal_splenocyte_physiolog1.34388385
75MP0005257_abnormal_intraocular_pressure1.32914453
76MP0002085_abnormal_embryonic_tissue1.32622202
77MP0000685_abnormal_immune_system1.31575887
78MP0004947_skin_inflammation1.31353402
79MP0003279_aneurysm1.29344024
80MP0001845_abnormal_inflammatory_respons1.28251515
81MP0010155_abnormal_intestine_physiology1.26292340
82MP0000350_abnormal_cell_proliferation1.24904121
83MP0003763_abnormal_thymus_physiology1.24264847
84MP0004381_abnormal_hair_follicle1.23990798
85MP0006082_CNS_inflammation1.23093905
86MP0001672_abnormal_embryogenesis/_devel1.23041359
87MP0005380_embryogenesis_phenotype1.23041359
88MP0005075_abnormal_melanosome_morpholog1.22699794
89MP0008469_abnormal_protein_level1.22361475
90MP0010307_abnormal_tumor_latency1.20872332
91MP0003828_pulmonary_edema1.20045026
92MP0001730_embryonic_growth_arrest1.19581572
93MP0002060_abnormal_skin_morphology1.19310419
94MP0000604_amyloidosis1.19162108
95MP0000465_gastrointestinal_hemorrhage1.18245934
96MP0005310_abnormal_salivary_gland1.18122509
97MP0005501_abnormal_skin_physiology1.17598407
98MP0003300_gastrointestinal_ulcer1.16870219
99MP0002019_abnormal_tumor_incidence1.15271787
100MP0002405_respiratory_system_inflammati1.14281596
101MP0000015_abnormal_ear_pigmentation1.13775885
102MP0009764_decreased_sensitivity_to1.13116893
103MP0005023_abnormal_wound_healing1.12989723
104MP0000470_abnormal_stomach_morphology1.12345272
105MP0000716_abnormal_immune_system1.12329540
106MP0006072_abnormal_retinal_apoptosis1.12287906
107MP0003566_abnormal_cell_adhesion1.11340302
108MP0002269_muscular_atrophy1.11101937
109MP0002398_abnormal_bone_marrow1.09716076
110MP0002429_abnormal_blood_cell1.08047126
111MP0002722_abnormal_immune_system1.07136738
112MP0002111_abnormal_tail_morphology1.05880424
113MP0002080_prenatal_lethality1.03953195
114MP0001216_abnormal_epidermal_layer1.03654490
115MP0005165_increased_susceptibility_to1.03390640
116MP0002998_abnormal_bone_remodeling1.03188230
117MP0005390_skeleton_phenotype1.02333659
118MP0001243_abnormal_dermal_layer1.01553863
119MP0001873_stomach_inflammation1.01400470
120MP0002254_reproductive_system_inflammat1.01319479
121MP0002132_abnormal_respiratory_system1.01206565
122MP0001849_ear_inflammation1.00652403
123MP0003984_embryonic_growth_retardation0.97703576
124MP0005408_hypopigmentation0.96802696
125MP0003718_maternal_effect0.95374775
126MP0002088_abnormal_embryonic_growth/wei0.93279952
127MP0001340_abnormal_eyelid_morphology0.93134582
128MP0008877_abnormal_DNA_methylation0.92928617
129MP0002396_abnormal_hematopoietic_system0.92775069
130MP0004510_myositis0.91793281
131MP0005319_abnormal_enzyme/_coenzyme0.89564909
132MP0002095_abnormal_skin_pigmentation0.89222342
133MP0006036_abnormal_mitochondrial_physio0.88709672
134MP0003329_amyloid_beta_deposits0.88073056
135MP0005508_abnormal_skeleton_morphology0.88018712
136MP0002166_altered_tumor_susceptibility0.86232800
137MP0004264_abnormal_extraembryonic_tissu0.85867488
138MP0005083_abnormal_biliary_tract0.85429430
139MP0009115_abnormal_fat_cell0.85061121
140MP0000358_abnormal_cell_content/0.84550062
141MP0000462_abnormal_digestive_system0.83409237
142MP0000639_abnormal_adrenal_gland0.82891217
143MP0000313_abnormal_cell_death0.82264974
144MP0001958_emphysema0.81703625
145MP0002932_abnormal_joint_morphology0.81381312
146MP0002075_abnormal_coat/hair_pigmentati0.80896573
147MP0003656_abnormal_erythrocyte_physiolo0.80801501
148MP0009053_abnormal_anal_canal0.79836485
149MP0000762_abnormal_tongue_morphology0.79104412
150MP0000689_abnormal_spleen_morphology0.78957688
151MP0009840_abnormal_foam_cell0.74731483
152MP0003795_abnormal_bone_structure0.74217287
153MP0005275_abnormal_skin_tensile0.72336449
154MP0003755_abnormal_palate_morphology0.71377331
155MP0005367_renal/urinary_system_phenotyp0.70568300
156MP0000516_abnormal_urinary_system0.70568300
157MP0000477_abnormal_intestine_morphology0.69197685
158MP0002006_tumorigenesis0.68891631
159MP0001186_pigmentation_phenotype0.67619069
160MP0003045_fibrosis0.67123458
161MP0002114_abnormal_axial_skeleton0.67008040
162MP0003448_altered_tumor_morphology0.66017035
163MP0004185_abnormal_adipocyte_glucose0.65734911
164MP0005266_abnormal_metabolism0.65596046
165MP0000367_abnormal_coat/_hair0.64449063
166MP0000432_abnormal_head_morphology0.63498113
167MP0003935_abnormal_craniofacial_develop0.63211005
168MP0003075_altered_response_to0.59839395
169MP0000467_abnormal_esophagus_morphology0.59509202

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)5.88974130
2Concave nail (HP:0001598)5.27001323
3Abnormality of glycolipid metabolism (HP:0010969)5.07239144
4Abnormality of liposaccharide metabolism (HP:0010968)5.07239144
5Abnormality of glycosphingolipid metabolism (HP:0004343)5.07239144
6Rib fusion (HP:0000902)5.06032429
7Annular pancreas (HP:0001734)4.81523544
8Increased IgM level (HP:0003496)4.78720466
9Facial hemangioma (HP:0000329)4.76461181
10Alopecia of scalp (HP:0002293)4.68057051
11Rectal fistula (HP:0100590)4.55619986
12Rectovaginal fistula (HP:0000143)4.55619986
13Poikiloderma (HP:0001029)4.30640258
14Ulnar bowing (HP:0003031)4.26135139
15Turricephaly (HP:0000262)4.22161371
16Aplasia/Hypoplasia involving the carpal bones (HP:0006502)4.08751421
17Vaginal fistula (HP:0004320)4.06765609
18Vertebral compression fractures (HP:0002953)4.06395388
19Intestinal fistula (HP:0100819)4.04584216
20Tongue fasciculations (HP:0001308)3.91125792
21Mucopolysacchariduria (HP:0008155)3.73000967
22Urinary glycosaminoglycan excretion (HP:0003541)3.73000967
23Muscle fibrillation (HP:0010546)3.67996868
24Coronal craniosynostosis (HP:0004440)3.64561477
25Short humerus (HP:0005792)3.61809028
26Vacuolated lymphocytes (HP:0001922)3.61750637
27Dysostosis multiplex (HP:0000943)3.60863508
28Aplasia/hypoplasia of the humerus (HP:0006507)3.57007319
29Abnormal hemoglobin (HP:0011902)3.54127466
30Increased cerebral lipofuscin (HP:0011813)3.48735223
31Aplasia/Hypoplasia of the vertebrae (HP:0008515)3.41558159
32Vertebral hypoplasia (HP:0008417)3.41558159
33Male infertility (HP:0003251)3.39405872
34Abnormality of macrophages (HP:0004311)3.37489053
35Abnormality of polysaccharide metabolism (HP:0011012)3.37232186
36Abnormality of glycosaminoglycan metabolism (HP:0004371)3.37232186
37Abnormality of mucopolysaccharide metabolism (HP:0011020)3.37232186
38Loss of speech (HP:0002371)3.31143065
39Orthostatic hypotension (HP:0001278)3.26669870
40Joint stiffness (HP:0001387)3.19702888
41Abnormality of male internal genitalia (HP:0000022)3.18452664
42Hepatosplenomegaly (HP:0001433)3.16058439
43Increased neuronal autofluorescent lipopigment (HP:0002074)3.13883516
44Absent radius (HP:0003974)3.11870203
45Hypotrichosis (HP:0001006)3.05955725
46Congenital hip dislocation (HP:0001374)3.05593568
47Squamous cell carcinoma (HP:0002860)3.03654304
48Recurrent abscess formation (HP:0002722)3.02349044
49Dysautonomia (HP:0002459)2.97864726
50Eczematoid dermatitis (HP:0000976)2.95811118
51Absent forearm bone (HP:0003953)2.93556108
52Aplasia involving forearm bones (HP:0009822)2.93556108
53Albinism (HP:0001022)2.92593545
54Short chin (HP:0000331)2.91166139
55Anteriorly placed anus (HP:0001545)2.89791904
56Recurrent bacterial skin infections (HP:0005406)2.88705692
57Hypochromic microcytic anemia (HP:0004840)2.88475568
58Premature skin wrinkling (HP:0100678)2.88138748
59Abnormality of the aortic arch (HP:0012303)2.87103842
60Cerebral aneurysm (HP:0004944)2.86561698
61Selective tooth agenesis (HP:0001592)2.84757473
62Absent thumb (HP:0009777)2.81446496
63Basal cell carcinoma (HP:0002671)2.81100844
64Polycythemia (HP:0001901)2.81006398
65Premature rupture of membranes (HP:0001788)2.80706183
66Intestinal atresia (HP:0011100)2.79612373
67Patellar aplasia (HP:0006443)2.73544906
68Rough bone trabeculation (HP:0100670)2.70644580
69Alacrima (HP:0000522)2.63867006
70Diaphragmatic weakness (HP:0009113)2.62011790
71Large for gestational age (HP:0001520)2.61477494
72Premature graying of hair (HP:0002216)2.61123716
73Hypokinesia (HP:0002375)2.60676072
74Choanal stenosis (HP:0000452)2.59375684
75Capillary hemangiomas (HP:0005306)2.59162407
76Bowing of the arm (HP:0006488)2.54465216
77Bowed forearm bones (HP:0003956)2.54465216
78Aplasia/Hypoplasia of the patella (HP:0006498)2.53259359
79Bifid uvula (HP:0000193)2.52753384
80Petechiae (HP:0000967)2.51134592
81Broad alveolar ridges (HP:0000187)2.50364771
82Ragged-red muscle fibers (HP:0003200)2.50057904
83Myositis (HP:0100614)2.49842954
84Upper motor neuron abnormality (HP:0002127)2.46401251
85Clumsiness (HP:0002312)2.41921728
86Hypertensive crisis (HP:0100735)2.40877909
87Elevated erythrocyte sedimentation rate (HP:0003565)2.38908251
88Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.36589732
89Hypochromic anemia (HP:0001931)2.35824050
90Abnormal gallbladder physiology (HP:0012438)2.35710107
91Cholecystitis (HP:0001082)2.35710107
92Generalized amyotrophy (HP:0003700)2.35575076
93Chronic obstructive pulmonary disease (HP:0006510)2.32257625
94Obstructive lung disease (HP:0006536)2.32257625
95Growth hormone excess (HP:0000845)2.32207359
96IgA deficiency (HP:0002720)2.30689086
97Abnormal trabecular bone morphology (HP:0100671)2.30252489
98J-shaped sella turcica (HP:0002680)2.28427850
99Hamartoma (HP:0010566)2.27001251
100Aplasia of the musculature (HP:0100854)2.26253055
101Abnormality of the umbilical cord (HP:0010881)2.26002072
102Entropion (HP:0000621)2.25725846
103Hypotelorism (HP:0000601)2.24727934
104Prolonged neonatal jaundice (HP:0006579)2.23702558
105Increased serum ferritin (HP:0003281)2.21408203
106Asymmetric septal hypertrophy (HP:0001670)2.20584305
107Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.19181697
108Decreased activity of mitochondrial respiratory chain (HP:0008972)2.19181697
109Redundant skin (HP:0001582)2.16695153
110Systemic lupus erythematosus (HP:0002725)2.15405878
111Vertebral fusion (HP:0002948)2.15072463
112Recurrent skin infections (HP:0001581)2.12453348
113Increased muscle lipid content (HP:0009058)2.12105193
114Spinal muscular atrophy (HP:0007269)2.11341106
115Increased intramyocellular lipid droplets (HP:0012240)2.10884837
116Type I transferrin isoform profile (HP:0003642)2.10349061
117Osteolytic defects of the hand bones (HP:0009699)2.10099136
118Osteolytic defects of the phalanges of the hand (HP:0009771)2.10099136
119Abnormality of the distal phalanges of the toes (HP:0010182)2.08707277
120Orchitis (HP:0100796)2.08645612
121Mediastinal lymphadenopathy (HP:0100721)2.08264715
122Stomatitis (HP:0010280)2.07093642
123Purpura (HP:0000979)2.06607794
124Abnormal umbilical cord blood vessels (HP:0011403)2.06086352
125Single umbilical artery (HP:0001195)2.06086352
126Abnormality of the fetal cardiovascular system (HP:0010948)2.06086352
127Cheilitis (HP:0100825)2.05903036
128Progressive neurologic deterioration (HP:0002344)2.03773134
129Cutaneous melanoma (HP:0012056)2.03633774
130Congenital ichthyosiform erythroderma (HP:0007431)2.02834808
131Axonal loss (HP:0003447)2.00628304
132Recurrent fungal infections (HP:0002841)1.99420117
133Hepatocellular necrosis (HP:0001404)1.98968072
134Hypoplasia of the radius (HP:0002984)1.98687959
135Popliteal pterygium (HP:0009756)1.97951676
136Split hand (HP:0001171)1.97676248
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.97385440
138Breast hypoplasia (HP:0003187)1.96906351
139Muscle fiber atrophy (HP:0100295)1.96624077
140Abnormal mitochondria in muscle tissue (HP:0008316)1.95716263
141Bulbar palsy (HP:0001283)1.95528826
142Narrow nasal bridge (HP:0000446)1.94277591
143Pancreatic islet-cell hyperplasia (HP:0004510)1.93592806
144Amelogenesis imperfecta (HP:0000705)1.93250177
145Decreased lacrimation (HP:0000633)1.91227632
146Hypergammaglobulinemia (HP:0010702)1.90866546
147Chronic mucocutaneous candidiasis (HP:0002728)1.90584330
148Recurrent cutaneous fungal infections (HP:0011370)1.90584330
149Nonimmune hydrops fetalis (HP:0001790)1.90129282
150Amyloidosis (HP:0011034)1.89798334
151Hypercortisolism (HP:0001578)1.89517555
152Progressive muscle weakness (HP:0003323)1.89317716
153Increased IgE level (HP:0003212)1.88655969
154Sparse eyelashes (HP:0000653)1.87674242
155Increased number of teeth (HP:0011069)1.87267710
156Abnormality of the labia minora (HP:0012880)1.87010420
157Fatigue (HP:0012378)1.86439188
158Acute lymphatic leukemia (HP:0006721)1.85533298
159Reduced subcutaneous adipose tissue (HP:0003758)1.85338740
160Oral leukoplakia (HP:0002745)1.85022533
161Nuclear cataract (HP:0100018)1.84698362
162Lower limb hyperreflexia (HP:0002395)1.84276040
163Short 5th finger (HP:0009237)1.83481773
164Spastic paraparesis (HP:0002313)1.83101147
165Trismus (HP:0000211)1.82830357
166Mitochondrial inheritance (HP:0001427)1.82825056
167Gastrointestinal dysmotility (HP:0002579)1.82789049
168Short nail (HP:0001799)1.81364173
169Hypoplasia of the ulna (HP:0003022)1.80869525
170Recurrent viral infections (HP:0004429)1.80830487
171Aplastic anemia (HP:0001915)1.80585778
172Degeneration of anterior horn cells (HP:0002398)1.80252584
173Abnormality of the anterior horn cell (HP:0006802)1.80252584
174Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.79739539
175Bilateral sensorineural hearing impairment (HP:0008619)1.77722919
176Microretrognathia (HP:0000308)1.77647473
177Exertional dyspnea (HP:0002875)1.76073517
178Microvesicular hepatic steatosis (HP:0001414)1.75722555
179Nail dystrophy (HP:0008404)1.75002413
180Urticaria (HP:0001025)1.74145826
181Palmoplantar hyperkeratosis (HP:0000972)1.72273031
182Premature loss of primary teeth (HP:0006323)1.71108399
183Distal lower limb muscle weakness (HP:0009053)1.70468995
184Achilles tendon contracture (HP:0001771)1.69907756
185Reduced antithrombin III activity (HP:0001976)1.69279863
186Protrusio acetabuli (HP:0003179)1.68924468
187Cellulitis (HP:0100658)1.67029365
188Acute necrotizing encephalopathy (HP:0006965)1.66535189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.56949536
2DDR24.98546492
3MAPK154.66811674
4MAP3K64.26852255
5MAP3K113.86655033
6PIM23.18712924
7MATK2.94760842
8IRAK32.90171798
9TESK12.87936562
10FGR2.80849190
11PINK12.78883503
12VRK22.72765128
13TYRO32.67663487
14BCKDK2.50548867
15BMX2.42088589
16DAPK12.34588328
17ARAF2.24239108
18CSK2.17995305
19UHMK12.00546359
20PDGFRA1.97850641
21PRKD21.91449029
22DYRK1B1.86784865
23CDK71.85673621
24TBK11.82393190
25YES11.78503945
26SMG11.73639600
27AKT31.63310330
28LATS21.59658317
29ABL21.57973770
30PIM11.57676152
31TYK21.56096035
32LIMK11.45925434
33CDK61.40135591
34TGFBR21.38329132
35TRPM71.37539560
36MAP3K121.32333724
37TXK1.29842633
38RPS6KC11.25967885
39RPS6KL11.25967885
40TRIB31.21612343
41LRRK21.18765079
42GRK61.15166205
43RPS6KA61.12462751
44GRK71.10866418
45EIF2AK11.09406460
46MST41.09082025
47MAP3K11.08809452
48SIK11.08605375
49STK161.07193549
50TAOK21.05624545
51DYRK31.05523803
52IRAK41.03087210
53MAP3K101.01072343
54GSK3A1.00265692
55CHEK20.99600945
56MAPK110.99289371
57BUB10.92518698
58PDK20.91824207
59ILK0.90445284
60PLK10.90094464
61NME10.87321587
62WEE10.87084916
63RIPK40.86455960
64EPHB10.86141822
65CDC42BPA0.85021047
66MARK30.84788685
67NME20.84730730
68PBK0.84225766
69EPHA20.83979232
70JAK30.83940805
71NEK20.80243254
72MOS0.78065539
73PRPF4B0.77267123
74IKBKE0.71952295
75MYLK0.68685688
76MTOR0.67978365
77RAF10.67470839
78ERN10.67032998
79RPS6KA10.66533152
80KIT0.66185070
81PHKG20.63289898
82PHKG10.63289898
83TNK20.62791258
84FES0.62658353
85BLK0.62293668
86MAP4K10.62075149
87MUSK0.61205672
88SIK30.60955945
89MAP3K140.60228712
90BRAF0.59614494
91TAOK10.58537938
92PRKCI0.58158097
93HIPK20.57080731
94RPS6KB20.53981943
95PRKD30.52390764
96DAPK30.51887544
97EGFR0.50748965
98IRAK20.50361777
99CSF1R0.49953393
100MAP3K50.49908676
101LYN0.49482870
102PRKAA10.49436249
103CLK10.48936801
104AURKA0.47926796
105STK30.47848097
106MAPKAPK30.45211933
107MAP2K20.44986574
108STK100.44616430
109ATR0.44235864
110CDK120.43586874
111CDK20.43073345
112CSNK2A10.43040890
113TESK20.42779223
114BRSK10.42605841
115MAPKAPK20.37184404
116PAK40.37090820
117TAOK30.35967604
118EPHB20.35057331
119CSNK1G30.34293087
120ALK0.33725738
121ERBB30.32936381
122NEK90.32623481
123DYRK20.32575051
124FER0.32534503
125PDGFRB0.32393152
126PTK20.31959002
127MST1R0.31878867
128CDK40.31717103
129PRKD10.31668291
130BRSK20.31653719
131PAK10.31396188
132MAPK40.31148321
133MAPK30.31092045
134MAPK10.30879242
135IKBKB0.29958414
136CSNK2A20.29573074
137AURKB0.29293609
138MAP3K30.29270863
139KDR0.28664443
140PAK20.28664344
141LMTK20.27798015
142CAMK2G0.25139085
143MAP3K80.24913958
144RIPK10.24654611
145CHEK10.24557856
146MAP3K90.24178587
147FLT30.23457676
148RPS6KB10.21427703
149PRKCD0.20837668
150SCYL20.20354617
151MAP2K30.19682953
152INSR0.19645878
153MAPK100.18869232
154NEK10.18785450
155LCK0.18609315
156ZAP700.18470045
157MAPK140.18454814

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.65937465
2Fatty acid biosynthesis_Homo sapiens_hsa000614.55579608
3Base excision repair_Homo sapiens_hsa034104.54598909
4DNA replication_Homo sapiens_hsa030303.94557268
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.65641968
6Other glycan degradation_Homo sapiens_hsa005112.48126653
7Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.34898510
8Nucleotide excision repair_Homo sapiens_hsa034202.24754375
9RNA transport_Homo sapiens_hsa030132.22568587
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.19781749
11Spliceosome_Homo sapiens_hsa030402.16356932
12Sulfur relay system_Homo sapiens_hsa041222.00661838
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.94183499
14p53 signaling pathway_Homo sapiens_hsa041151.90981338
15Notch signaling pathway_Homo sapiens_hsa043301.84565776
16Fatty acid elongation_Homo sapiens_hsa000621.84508461
17mTOR signaling pathway_Homo sapiens_hsa041501.84001650
18Rheumatoid arthritis_Homo sapiens_hsa053231.79623345
19Hippo signaling pathway_Homo sapiens_hsa043901.76880897
20Homologous recombination_Homo sapiens_hsa034401.74180386
21mRNA surveillance pathway_Homo sapiens_hsa030151.71197849
22Arginine and proline metabolism_Homo sapiens_hsa003301.67990375
23Pentose phosphate pathway_Homo sapiens_hsa000301.66540305
24Shigellosis_Homo sapiens_hsa051311.60272301
25Antigen processing and presentation_Homo sapiens_hsa046121.58950970
26Hedgehog signaling pathway_Homo sapiens_hsa043401.55570778
27Ribosome_Homo sapiens_hsa030101.55252365
28Cell cycle_Homo sapiens_hsa041101.53808607
29Adherens junction_Homo sapiens_hsa045201.50593266
30Circadian rhythm_Homo sapiens_hsa047101.50198487
31Vibrio cholerae infection_Homo sapiens_hsa051101.49518415
32Osteoclast differentiation_Homo sapiens_hsa043801.49095761
33Folate biosynthesis_Homo sapiens_hsa007901.48855705
34Bladder cancer_Homo sapiens_hsa052191.48210281
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.43408674
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.42554531
37Biosynthesis of amino acids_Homo sapiens_hsa012301.40953347
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.40893358
39Allograft rejection_Homo sapiens_hsa053301.39495260
40Sulfur metabolism_Homo sapiens_hsa009201.37377611
41Oxidative phosphorylation_Homo sapiens_hsa001901.35481483
42RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.33031052
43Fanconi anemia pathway_Homo sapiens_hsa034601.32679083
44TGF-beta signaling pathway_Homo sapiens_hsa043501.30286825
45Malaria_Homo sapiens_hsa051441.29694258
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.25586387
47Graft-versus-host disease_Homo sapiens_hsa053321.24921303
48NF-kappa B signaling pathway_Homo sapiens_hsa040641.23603421
49Proteasome_Homo sapiens_hsa030501.22966435
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.21746650
51Longevity regulating pathway - mammal_Homo sapiens_hsa042111.21578515
52Leishmaniasis_Homo sapiens_hsa051401.21353141
53Phagosome_Homo sapiens_hsa041451.19307952
54Transcriptional misregulation in cancer_Homo sapiens_hsa052021.18188500
55Tuberculosis_Homo sapiens_hsa051521.17658595
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17199681
57Autoimmune thyroid disease_Homo sapiens_hsa053201.11968359
58VEGF signaling pathway_Homo sapiens_hsa043701.08697228
59Hematopoietic cell lineage_Homo sapiens_hsa046401.06564712
60Parkinsons disease_Homo sapiens_hsa050121.05424695
61RNA polymerase_Homo sapiens_hsa030201.04784521
62Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03993663
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.03725742
64Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00475415
65Legionellosis_Homo sapiens_hsa051340.98629352
66Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.95323896
67Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.94591181
68Basal cell carcinoma_Homo sapiens_hsa052170.94173744
69Collecting duct acid secretion_Homo sapiens_hsa049660.93827767
70Fructose and mannose metabolism_Homo sapiens_hsa000510.93706167
71Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91318708
72Acute myeloid leukemia_Homo sapiens_hsa052210.90924868
73Influenza A_Homo sapiens_hsa051640.90466379
74TNF signaling pathway_Homo sapiens_hsa046680.90294903
75Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89771984
76Lysosome_Homo sapiens_hsa041420.89606518
77Carbon metabolism_Homo sapiens_hsa012000.89373962
78Pertussis_Homo sapiens_hsa051330.88858618
79Wnt signaling pathway_Homo sapiens_hsa043100.87425019
80Primary immunodeficiency_Homo sapiens_hsa053400.85059935
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.83925335
82Colorectal cancer_Homo sapiens_hsa052100.81625713
83Oocyte meiosis_Homo sapiens_hsa041140.81551196
84Chronic myeloid leukemia_Homo sapiens_hsa052200.81338229
85Thyroid cancer_Homo sapiens_hsa052160.78818638
86Prion diseases_Homo sapiens_hsa050200.78434721
87Sphingolipid metabolism_Homo sapiens_hsa006000.76924273
88MicroRNAs in cancer_Homo sapiens_hsa052060.75313086
89Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.75265953
90Fatty acid metabolism_Homo sapiens_hsa012120.74710455
91Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74393599
92Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73770293
93Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73442330
94Viral myocarditis_Homo sapiens_hsa054160.72641726
95Alzheimers disease_Homo sapiens_hsa050100.71890530
96Huntingtons disease_Homo sapiens_hsa050160.70055791
97Small cell lung cancer_Homo sapiens_hsa052220.69417943
98Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.69246145
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67834006
100Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.66992274
101Toxoplasmosis_Homo sapiens_hsa051450.66465748
102Non-homologous end-joining_Homo sapiens_hsa034500.65817724
103Epstein-Barr virus infection_Homo sapiens_hsa051690.64095170
104Viral carcinogenesis_Homo sapiens_hsa052030.63823546
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62891268
106Pyrimidine metabolism_Homo sapiens_hsa002400.62275185
107Herpes simplex infection_Homo sapiens_hsa051680.62020250
108Galactose metabolism_Homo sapiens_hsa000520.60830202
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.58959059
110One carbon pool by folate_Homo sapiens_hsa006700.58314448
111Hepatitis C_Homo sapiens_hsa051600.57187802
112African trypanosomiasis_Homo sapiens_hsa051430.56169164
113Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55818180
114Cyanoamino acid metabolism_Homo sapiens_hsa004600.55393916
115Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55319530
116NOD-like receptor signaling pathway_Homo sapiens_hsa046210.53542797
117Proteoglycans in cancer_Homo sapiens_hsa052050.53071294
118Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52863020
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51281799
120Tight junction_Homo sapiens_hsa045300.51076735
121Lysine degradation_Homo sapiens_hsa003100.51038285
122Steroid biosynthesis_Homo sapiens_hsa001000.50411773
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47075528
124Leukocyte transendothelial migration_Homo sapiens_hsa046700.46259773
125HTLV-I infection_Homo sapiens_hsa051660.45698028
126Hepatitis B_Homo sapiens_hsa051610.45646828
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.45550897
128Glutathione metabolism_Homo sapiens_hsa004800.44018251
129Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.41497694
130ErbB signaling pathway_Homo sapiens_hsa040120.37507597
131Choline metabolism in cancer_Homo sapiens_hsa052310.37350616
132Apoptosis_Homo sapiens_hsa042100.37034395
133AMPK signaling pathway_Homo sapiens_hsa041520.36742386
134Endocytosis_Homo sapiens_hsa041440.36406897
135Central carbon metabolism in cancer_Homo sapiens_hsa052300.35282151
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.34170195
137Insulin signaling pathway_Homo sapiens_hsa049100.33957898
138Arginine biosynthesis_Homo sapiens_hsa002200.33851113
139Staphylococcus aureus infection_Homo sapiens_hsa051500.32461116
140B cell receptor signaling pathway_Homo sapiens_hsa046620.32433331
141Focal adhesion_Homo sapiens_hsa045100.32369283
142HIF-1 signaling pathway_Homo sapiens_hsa040660.32334218
143Salmonella infection_Homo sapiens_hsa051320.29649756
144RNA degradation_Homo sapiens_hsa030180.29432970
145Dorso-ventral axis formation_Homo sapiens_hsa043200.28649097
146N-Glycan biosynthesis_Homo sapiens_hsa005100.28433368
147Gap junction_Homo sapiens_hsa045400.28309721
148Measles_Homo sapiens_hsa051620.27620457
149Basal transcription factors_Homo sapiens_hsa030220.27539645
150Pathways in cancer_Homo sapiens_hsa052000.26686631
151Endometrial cancer_Homo sapiens_hsa052130.26424158
152Pancreatic cancer_Homo sapiens_hsa052120.26104414
153Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.25235635
154AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.23698857
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23219138
156Prostate cancer_Homo sapiens_hsa052150.23160421

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