MFSD6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.58090263
2synaptic vesicle exocytosis (GO:0016079)4.24752665
3axonemal dynein complex assembly (GO:0070286)4.23963552
4synaptic vesicle maturation (GO:0016188)4.12701478
5vocalization behavior (GO:0071625)4.02733993
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.97681165
7neuron cell-cell adhesion (GO:0007158)3.96939909
8cilium or flagellum-dependent cell motility (GO:0001539)3.95829343
9glutamate secretion (GO:0014047)3.94650430
10regulation of synaptic vesicle exocytosis (GO:2000300)3.92782163
11locomotory exploration behavior (GO:0035641)3.78823927
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.71106294
13neuronal action potential propagation (GO:0019227)3.66714842
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.59701327
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.54989275
16regulation of glutamate receptor signaling pathway (GO:1900449)3.40533279
17regulation of synaptic vesicle transport (GO:1902803)3.39661823
18protein localization to synapse (GO:0035418)3.34709783
19neurotransmitter secretion (GO:0007269)3.34522468
20cellular potassium ion homeostasis (GO:0030007)3.33923332
21glutamate receptor signaling pathway (GO:0007215)3.23055962
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.19897321
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.19046790
24exploration behavior (GO:0035640)3.18497320
25proline transport (GO:0015824)3.17330374
26regulation of neuronal synaptic plasticity (GO:0048168)3.14601653
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.13243949
28positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.13014708
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.11596883
30neuron recognition (GO:0008038)3.10421739
31regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00433.08639865
32vesicle transport along microtubule (GO:0047496)3.06901566
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.03031146
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.01410681
35neuron-neuron synaptic transmission (GO:0007270)2.99627051
36positive regulation of Rap GTPase activity (GO:0032854)2.98747562
37regulation of vesicle fusion (GO:0031338)2.98409683
38cerebellar Purkinje cell differentiation (GO:0021702)2.97210538
39mating behavior (GO:0007617)2.96416537
40neurotransmitter transport (GO:0006836)2.96408375
41synaptic vesicle docking involved in exocytosis (GO:0016081)2.95392687
42sodium ion export (GO:0071436)2.94342532
43layer formation in cerebral cortex (GO:0021819)2.93477262
44dendritic spine morphogenesis (GO:0060997)2.92805720
45motile cilium assembly (GO:0044458)2.92644586
46synaptic transmission, glutamatergic (GO:0035249)2.89344206
47regulation of synapse structural plasticity (GO:0051823)2.88694686
48cilium movement (GO:0003341)2.87079912
49negative regulation of synaptic transmission, GABAergic (GO:0032229)2.85268661
50cerebellar granule cell differentiation (GO:0021707)2.84644779
51regulation of excitatory postsynaptic membrane potential (GO:0060079)2.84158301
52negative regulation of neurotransmitter transport (GO:0051589)2.84155096
53activation of protein kinase A activity (GO:0034199)2.80432999
54presynaptic membrane assembly (GO:0097105)2.79869493
55protein localization to endosome (GO:0036010)2.79797611
56transmission of nerve impulse (GO:0019226)2.78778040
57cellular response to nerve growth factor stimulus (GO:1990090)2.78176629
58response to nerve growth factor (GO:1990089)2.78176629
59long-chain fatty acid biosynthetic process (GO:0042759)2.75372802
60axonal fasciculation (GO:0007413)2.74518067
61regulation of postsynaptic membrane potential (GO:0060078)2.74212281
62regulation of neurotransmitter levels (GO:0001505)2.73669461
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.72593818
64gamma-aminobutyric acid transport (GO:0015812)2.71341963
65response to histamine (GO:0034776)2.70318825
66presynaptic membrane organization (GO:0097090)2.69790637
67regulation of neurotransmitter secretion (GO:0046928)2.67763657
68synaptic vesicle endocytosis (GO:0048488)2.65939613
69long-term memory (GO:0007616)2.65811361
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.65572191
71glycine transport (GO:0015816)2.65208105
72organelle transport along microtubule (GO:0072384)2.64750827
73multicellular organismal water homeostasis (GO:0050891)2.64292243
74neuromuscular process controlling posture (GO:0050884)2.64246625
75long-term synaptic potentiation (GO:0060291)2.62874334
76regulation of synaptic plasticity (GO:0048167)2.61314838
77synapse assembly (GO:0007416)2.60732696
78cellular sodium ion homeostasis (GO:0006883)2.59866973
79membrane depolarization during action potential (GO:0086010)2.59819871
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.59672951
81nerve growth factor signaling pathway (GO:0038180)2.59647831
82detection of calcium ion (GO:0005513)2.59365932
83negative regulation of dendrite morphogenesis (GO:0050774)2.58512210
84adult walking behavior (GO:0007628)2.58476579
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.58319010
86regulation of water loss via skin (GO:0033561)2.58114521
87L-amino acid import (GO:0043092)2.56961099
88regulation of clathrin-mediated endocytosis (GO:2000369)2.56925468
89hypotonic response (GO:0006971)2.55302390
90membrane depolarization (GO:0051899)2.53010596
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.52782335
92regulation of Rap GTPase activity (GO:0032317)2.52770583
93positive regulation of fibroblast migration (GO:0010763)2.52759718
94protein targeting to Golgi (GO:0000042)2.52733735
95regulation of synaptic transmission, glutamatergic (GO:0051966)2.52704680
96regulation of interleukin-13 production (GO:0032656)2.52591691
97cell communication involved in cardiac conduction (GO:0086065)2.52580350
98membrane hyperpolarization (GO:0060081)2.52161846
99regulation of neurotransmitter transport (GO:0051588)2.51874804
100dendrite morphogenesis (GO:0048813)2.51713190
101positive regulation of membrane potential (GO:0045838)2.51539350
102neuron remodeling (GO:0016322)2.51005457
103potassium ion homeostasis (GO:0055075)2.50809388
104establishment of skin barrier (GO:0061436)2.50427835
105regulation of voltage-gated calcium channel activity (GO:1901385)2.49363857
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.48914948
107desmosome organization (GO:0002934)2.48730706
108positive regulation of potassium ion transmembrane transport (GO:1901381)2.48617151
109positive regulation of neurotransmitter transport (GO:0051590)2.48395745
110positive regulation of synaptic transmission, GABAergic (GO:0032230)2.46706835
111one-carbon compound transport (GO:0019755)2.45965511
112regulation of ARF protein signal transduction (GO:0032012)2.42635913
113behavioral response to cocaine (GO:0048148)2.42499096
114innervation (GO:0060384)2.40140828
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.40051205
116positive regulation of potassium ion transport (GO:0043268)2.39964135
117synaptic transmission (GO:0007268)2.37556523
118prepulse inhibition (GO:0060134)2.37358257
119positive regulation of neurotransmitter secretion (GO:0001956)2.37265941
120axon ensheathment in central nervous system (GO:0032291)2.36626799
121central nervous system myelination (GO:0022010)2.36626799
122establishment of protein localization to Golgi (GO:0072600)2.36251814
123learning (GO:0007612)2.35318136
124potassium ion import (GO:0010107)2.32162127
125negative regulation of inclusion body assembly (GO:0090084)2.30464825
126peptidyl-tyrosine autophosphorylation (GO:0038083)2.30414070
127macroautophagy (GO:0016236)2.28553690
128negative regulation of erythrocyte differentiation (GO:0045647)2.28202670
129regulation of germinal center formation (GO:0002634)2.25377920
130myelin maintenance (GO:0043217)2.25227870
131regulation of interleukin-5 production (GO:0032674)2.23360908
132water homeostasis (GO:0030104)2.23003044
133sodium ion homeostasis (GO:0055078)2.21289538
134epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.19878752
135regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.18665810
136amino acid import (GO:0043090)2.13324936
137negative regulation of glycoprotein biosynthetic process (GO:0010561)2.13007446
138hemidesmosome assembly (GO:0031581)2.12860357
139tolerance induction (GO:0002507)2.11723966
140signal complex assembly (GO:0007172)2.11168317
141axoneme assembly (GO:0035082)2.08969312
142negative regulation of B cell mediated immunity (GO:0002713)2.08568082
143negative regulation of immunoglobulin mediated immune response (GO:0002890)2.08568082
144antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.06552576
145germinal center formation (GO:0002467)2.05182450
146cell communication by electrical coupling (GO:0010644)2.05098620
147import into cell (GO:0098657)2.03759248
148antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.01688166
149surfactant homeostasis (GO:0043129)2.01114321
150membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.01059996
151negative regulation of neurotransmitter secretion (GO:0046929)2.00004340
152antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)1.97931882
153cellular response to antibiotic (GO:0071236)1.97324312
154negative regulation of hormone metabolic process (GO:0032351)1.93120731
155negative regulation of hormone biosynthetic process (GO:0032353)1.91720339
156cell volume homeostasis (GO:0006884)1.90780167
157positive regulation of vesicle fusion (GO:0031340)1.90045043
158Golgi to endosome transport (GO:0006895)1.89540484
159relaxation of cardiac muscle (GO:0055119)1.89460659
160regulation of RIG-I signaling pathway (GO:0039535)1.89414382
161negative regulation of lymphocyte mediated immunity (GO:0002707)1.89382490
162cellular response to epinephrine stimulus (GO:0071872)1.88766275
163iron ion import (GO:0097286)1.88663257
164regulation of gamma-delta T cell differentiation (GO:0045586)1.88191864
165regulation of beta-amyloid formation (GO:1902003)1.87634660
166positive regulation of cellular amide metabolic process (GO:0034250)1.87384168

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.14683886
2GBX2_23144817_ChIP-Seq_PC3_Human3.15819188
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.85792809
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.70002526
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67312583
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.54909910
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.34916550
8SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32366480
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.26145234
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.26145234
11* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24692829
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.24547107
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24292530
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.23292564
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15605868
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15504038
17TAF15_26573619_Chip-Seq_HEK293_Human2.08622286
18AR_21572438_ChIP-Seq_LNCaP_Human2.05546526
19DROSHA_22980978_ChIP-Seq_HELA_Human2.01337467
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.00090374
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93476115
22REST_21632747_ChIP-Seq_MESCs_Mouse1.91833791
23EED_16625203_ChIP-ChIP_MESCs_Mouse1.90020328
24EZH2_27294783_Chip-Seq_ESCs_Mouse1.88122161
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.82608296
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81541430
27RARB_27405468_Chip-Seq_BRAIN_Mouse1.70656477
28* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65023275
29PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.64753212
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61941031
31IRF8_22096565_ChIP-ChIP_GC-B_Human1.59198839
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.57359334
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.56432545
34ESR1_21235772_ChIP-Seq_MCF-7_Human1.55376968
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54185356
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.53858875
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.52366839
38ZFP57_27257070_Chip-Seq_ESCs_Mouse1.52207020
39REST_18959480_ChIP-ChIP_MESCs_Mouse1.50136686
40GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.49614535
41FOXO3_23340844_ChIP-Seq_DLD1_Human1.48751928
42NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.47682395
43TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.47099673
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.46509952
45* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.45768634
46SMAD_19615063_ChIP-ChIP_OVARY_Human1.45705064
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.44510179
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.44438010
49* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.42820871
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.42154537
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.40424028
52P300_19829295_ChIP-Seq_ESCs_Human1.38167835
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.38159210
54RUNX_20019798_ChIP-Seq_JUKART_Human1.38035651
55* AHR_22903824_ChIP-Seq_MCF-7_Human1.37002003
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.35660435
57FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.35209700
58GATA1_19941826_ChIP-Seq_K562_Human1.35186189
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35008888
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33293768
61SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32529099
62OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.32506499
63THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.32346306
64* ARNT_22903824_ChIP-Seq_MCF-7_Human1.31594381
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31017793
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.30924206
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.30138067
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29268235
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27682235
70SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27568775
71AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27316383
72ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.27224190
73SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.26551796
74SOX2_20726797_ChIP-Seq_SW620_Human1.26168023
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26122858
76AR_25329375_ChIP-Seq_VCAP_Human1.25490928
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23998263
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.22707110
79CDX2_20551321_ChIP-Seq_CACO-2_Human1.22277941
80* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.20804587
81FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.19686078
82IGF1R_20145208_ChIP-Seq_DFB_Human1.19459970
83TP53_18474530_ChIP-ChIP_U2OS_Human1.18501072
84* IRF8_27001747_Chip-Seq_BMDM_Mouse1.17827580
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.17160421
86* STAT3_23295773_ChIP-Seq_U87_Human1.16195453
87TP53_16413492_ChIP-PET_HCT116_Human1.15004101
88GATA2_19941826_ChIP-Seq_K562_Human1.13572458
89VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12447015
90GATA1_22025678_ChIP-Seq_K562_Human1.11489265
91MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.11362193
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.11257199
93PRDM14_20953172_ChIP-Seq_ESCs_Human1.10190112
94KDM2B_26808549_Chip-Seq_K562_Human1.09994454
95* RUNX1_27514584_Chip-Seq_MCF-7_Human1.09003230
96PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.08862847
97ESR1_20079471_ChIP-ChIP_T-47D_Human1.08297225
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.07969927
99GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07806518
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07507132
101TP63_23658742_ChIP-Seq_EP156T_Human1.07150155
102* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06698318
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06039824
104BCAT_22108803_ChIP-Seq_LS180_Human1.05727962
105FOXA2_19822575_ChIP-Seq_HepG2_Human1.05541836
106SPI1_23127762_ChIP-Seq_K562_Human1.05338042
107VDR_22108803_ChIP-Seq_LS180_Human1.04776208
108VDR_24787735_ChIP-Seq_THP-1_Human1.04700710
109GATA1_19941827_ChIP-Seq_MEL_Mouse1.04246991
110ZNF274_21170338_ChIP-Seq_K562_Hela1.03400835
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.03379974
112P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03264114
113NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02935400
114EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02387856
115ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02334442
116AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.02014615
117CBX2_27304074_Chip-Seq_ESCs_Mouse1.01788599
118CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.01024179
119TCF7_22412390_ChIP-Seq_EML_Mouse1.01022500
120TCF4_23295773_ChIP-Seq_U87_Human1.00964528
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00684400
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00595402
123NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.99775328
124* RING1B_27294783_Chip-Seq_ESCs_Mouse0.99555567
125UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98436329
126KLF5_25053715_ChIP-Seq_YYC3_Human0.97394730
127RUNX2_22187159_ChIP-Seq_PCA_Human0.97209935
128STAT6_21828071_ChIP-Seq_BEAS2B_Human0.97130976
129RXR_22108803_ChIP-Seq_LS180_Human0.97123404
130NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97083210
131SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.96646014
132STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.96471116
133ESR2_21235772_ChIP-Seq_MCF-7_Human0.96235698
134ER_23166858_ChIP-Seq_MCF-7_Human0.95717284
135AR_19668381_ChIP-Seq_PC3_Human0.94882733
136NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94588971
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.94425426
138TBX20_22080862_ChIP-Seq_HEART_Mouse0.94425426
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93955560
140* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93707929
141SMAD3_21741376_ChIP-Seq_HESCs_Human0.93458918
142YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92943297
143PPAR_26484153_Chip-Seq_NCI-H1993_Human0.92746581
144BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92364275
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.92067878
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92042138
147SMAD4_21741376_ChIP-Seq_HESCs_Human0.91991290
148NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91656717
149NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91656717
150E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.91203945
151SMAD3_21741376_ChIP-Seq_ESCs_Human0.91091410
152RNF2_27304074_Chip-Seq_NSC_Mouse0.91032668
153KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90978419
154SCL_19346495_ChIP-Seq_HPC-7_Human0.90681392
155DNAJC2_21179169_ChIP-ChIP_NT2_Human0.89689042
156* NANOG_18555785_Chip-Seq_ESCs_Mouse0.89501096
157* LXR_22292898_ChIP-Seq_THP-1_Human0.89177320
158RACK7_27058665_Chip-Seq_MCF-7_Human0.86600032
159MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.86423211
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86235833
161NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82837483
162FOXM1_26456572_ChIP-Seq_MCF-7_Human0.81834502
163MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.81603558
164BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.81375021
165PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80425306
166SMC4_20622854_ChIP-Seq_HELA_Human0.79603465
167* TP63_22573176_ChIP-Seq_HFKS_Human0.79580935
168SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.78249404
169SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.78249404

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.93057761
2MP0003880_abnormal_central_pattern4.53376155
3MP0004270_analgesia3.66110796
4MP0003635_abnormal_synaptic_transmissio3.50235233
5MP0009745_abnormal_behavioral_response2.94753128
6MP0001968_abnormal_touch/_nociception2.86590517
7MP0002064_seizures2.85584895
8MP0009046_muscle_twitch2.78125725
9MP0002063_abnormal_learning/memory/cond2.70568788
10MP0002734_abnormal_mechanical_nocicepti2.59577638
11MP0002822_catalepsy2.51958231
12MP0002735_abnormal_chemical_nociception2.49990654
13MP0002272_abnormal_nervous_system2.47956842
14MP0005423_abnormal_somatic_nervous2.44499765
15MP0010234_abnormal_vibrissa_follicle2.42961347
16MP0002572_abnormal_emotion/affect_behav2.41819748
17MP0001501_abnormal_sleep_pattern2.38715118
18MP0001486_abnormal_startle_reflex2.25069570
19MP0002736_abnormal_nociception_after2.23296078
20MP0002733_abnormal_thermal_nociception2.14790458
21MP0003303_peritoneal_inflammation2.12509190
22MP0001970_abnormal_pain_threshold2.11230150
23MP0001440_abnormal_grooming_behavior2.06171629
24MP0006276_abnormal_autonomic_nervous2.04238415
25MP0003329_amyloid_beta_deposits2.00704412
26MP0003300_gastrointestinal_ulcer1.95874109
27MP0003453_abnormal_keratinocyte_physiol1.88987898
28MP0008004_abnormal_stomach_pH1.87928377
29MP0003172_abnormal_lysosome_physiology1.84236110
30MP0002067_abnormal_sensory_capabilities1.82621068
31MP0009780_abnormal_chondrocyte_physiolo1.80087857
32MP0004947_skin_inflammation1.79080467
33MP0002909_abnormal_adrenal_gland1.75420807
34MP0004858_abnormal_nervous_system1.70853262
35MP0008569_lethality_at_weaning1.69061097
36MP0005386_behavior/neurological_phenoty1.65415327
37MP0004924_abnormal_behavior1.65415327
38MP0002184_abnormal_innervation1.63802035
39MP0005645_abnormal_hypothalamus_physiol1.63661274
40MP0000778_abnormal_nervous_system1.57709810
41MP0000920_abnormal_myelination1.57325843
42MP0001790_abnormal_immune_system1.56228643
43MP0005387_immune_system_phenotype1.56228643
44MP0001905_abnormal_dopamine_level1.52446859
45MP0010386_abnormal_urinary_bladder1.51604208
46MP0002557_abnormal_social/conspecific_i1.49681041
47MP0001984_abnormal_olfaction1.49553103
48MP0008875_abnormal_xenobiotic_pharmacok1.46346703
49MP0004885_abnormal_endolymph1.43444807
50MP0003633_abnormal_nervous_system1.41818566
51MP0004811_abnormal_neuron_physiology1.40399254
52MP0010155_abnormal_intestine_physiology1.40118946
53MP0000383_abnormal_hair_follicle1.38013088
54MP0004264_abnormal_extraembryonic_tissu1.37183935
55MP0001529_abnormal_vocalization1.36614471
56MP0005646_abnormal_pituitary_gland1.35982716
57MP0003191_abnormal_cellular_cholesterol1.33153730
58MP0005166_decreased_susceptibility_to1.33022013
59MP0003724_increased_susceptibility_to1.32780948
60MP0000955_abnormal_spinal_cord1.31463851
61MP0003763_abnormal_thymus_physiology1.31043662
62MP0002796_impaired_skin_barrier1.28363379
63MP0001851_eye_inflammation1.25600481
64MP0003879_abnormal_hair_cell1.25356660
65MP0004142_abnormal_muscle_tone1.24745046
66MP0004742_abnormal_vestibular_system1.23480551
67MP0006082_CNS_inflammation1.22622440
68MP0002882_abnormal_neuron_morphology1.22163472
69MP0003690_abnormal_glial_cell1.21360049
70MP0004381_abnormal_hair_follicle1.20800471
71MP0003787_abnormal_imprinting1.20688212
72MP0002066_abnormal_motor_capabilities/c1.19946244
73MP0003631_nervous_system_phenotype1.14819124
74MP0000465_gastrointestinal_hemorrhage1.14003046
75MP0001502_abnormal_circadian_rhythm1.12189299
76MP0000604_amyloidosis1.10613140
77MP0008260_abnormal_autophagy1.10279116
78MP0002229_neurodegeneration1.10041481
79MP0001664_abnormal_digestion1.08380245
80MP0003634_abnormal_glial_cell1.07099996
81MP0002877_abnormal_melanocyte_morpholog1.05623430
82MP0002837_dystrophic_cardiac_calcinosis1.04032823
83MP0005058_abnormal_lysosome_morphology1.03363573
84MP0003183_abnormal_peptide_metabolism1.02475096
85MP0001835_abnormal_antigen_presentation1.01360668
86MP0005000_abnormal_immune_tolerance0.99447799
87MP0004510_myositis0.98627864
88MP0002166_altered_tumor_susceptibility0.98532753
89MP0005310_abnormal_salivary_gland0.97945978
90MP0001188_hyperpigmentation0.96846891
91MP0005165_increased_susceptibility_to0.96466677
92MP0005409_darkened_coat_color0.96251294
93MP0001216_abnormal_epidermal_layer0.95747653
94MP0000685_abnormal_immune_system0.95237359
95MP0008874_decreased_physiological_sensi0.94095138
96MP0003091_abnormal_cell_migration0.93855382
97MP0002998_abnormal_bone_remodeling0.93073556
98MP0003045_fibrosis0.93064471
99MP0000569_abnormal_digit_pigmentation0.93059546
100MP0003566_abnormal_cell_adhesion0.92752538
101MP0008872_abnormal_physiological_respon0.92566597
102MP0010352_gastrointestinal_tract_polyps0.92018353
103MP0004782_abnormal_surfactant_physiolog0.91072716
104MP0010678_abnormal_skin_adnexa0.90456703
105MP0003436_decreased_susceptibility_to0.90196093
106MP0005464_abnormal_platelet_physiology0.89315169
107MP0005501_abnormal_skin_physiology0.88739032
108MP0003656_abnormal_erythrocyte_physiolo0.88405343
109MP0005671_abnormal_response_to0.88099725
110MP0004019_abnormal_vitamin_homeostasis0.87723856
111MP0001800_abnormal_humoral_immune0.87449250
112MP0000751_myopathy0.86237757
113MP0005025_abnormal_response_to0.85891696
114MP0005535_abnormal_body_temperature0.85314264
115MP0003632_abnormal_nervous_system0.83811260
116MP0008961_abnormal_basal_metabolism0.83510785
117MP0005551_abnormal_eye_electrophysiolog0.82660431
118MP0003075_altered_response_to0.79729015
119MP0002098_abnormal_vibrissa_morphology0.79186372
120MP0002090_abnormal_vision0.78548486
121MP0004085_abnormal_heartbeat0.77597773
122MP0001177_atelectasis0.77517525
123MP0001881_abnormal_mammary_gland0.75510420
124MP0003828_pulmonary_edema0.74555191
125MP0002069_abnormal_eating/drinking_beha0.72201212
126MP0003122_maternal_imprinting0.71920748
127MP0004484_altered_response_of0.71282304
128MP0001765_abnormal_ion_homeostasis0.70943214
129MP0002152_abnormal_brain_morphology0.70738521
130MP0000579_abnormal_nail_morphology0.69900512
131MP0001299_abnormal_eye_distance/0.67917050
132MP0000538_abnormal_urinary_bladder0.67560444
133MP0001963_abnormal_hearing_physiology0.67038099
134MP0004145_abnormal_muscle_electrophysio0.64291193
135MP0004043_abnormal_pH_regulation0.64203960
136MP0005499_abnormal_olfactory_system0.62833250
137MP0005394_taste/olfaction_phenotype0.62833250
138MP0003866_abnormal_defecation0.62392026
139MP0002752_abnormal_somatic_nervous0.62391224
140MP0002009_preneoplasia0.62106022
141MP0001485_abnormal_pinna_reflex0.61418300
142MP0002876_abnormal_thyroid_physiology0.60960911
143MP0001348_abnormal_lacrimal_gland0.58830272
144MP0010771_integument_phenotype0.57055986
145MP0005623_abnormal_meninges_morphology0.54271666

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.21246375
2Myokymia (HP:0002411)5.40356224
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.09201262
4Focal seizures (HP:0007359)4.74018946
5Dynein arm defect of respiratory motile cilia (HP:0012255)4.60842255
6Absent/shortened dynein arms (HP:0200106)4.60842255
7Visual hallucinations (HP:0002367)4.55129378
8Abnormal respiratory epithelium morphology (HP:0012253)4.46610449
9Abnormal respiratory motile cilium morphology (HP:0005938)4.46610449
10Abnormal ciliary motility (HP:0012262)4.42303665
11Abnormal respiratory motile cilium physiology (HP:0012261)4.38740909
12Atonic seizures (HP:0010819)4.28985924
13Supranuclear gaze palsy (HP:0000605)4.24989722
14Rhinitis (HP:0012384)4.19730120
15Nasal polyposis (HP:0100582)3.88010641
16Neurofibrillary tangles (HP:0002185)3.86612762
17Progressive cerebellar ataxia (HP:0002073)3.79433551
18Epileptic encephalopathy (HP:0200134)3.66092766
19Febrile seizures (HP:0002373)3.65061873
20Absence seizures (HP:0002121)3.60561530
21Cerebral inclusion bodies (HP:0100314)3.58466435
22Bronchiectasis (HP:0002110)3.53592255
23Chronic bronchitis (HP:0004469)3.45194765
24Action tremor (HP:0002345)3.44124916
25Dialeptic seizures (HP:0011146)3.37925618
26Abnormality of the nasal mucosa (HP:0000433)3.29960133
27Ankle clonus (HP:0011448)3.26359746
28Generalized tonic-clonic seizures (HP:0002069)3.26310739
29Hyperactive renin-angiotensin system (HP:0000841)3.11597943
30Truncal ataxia (HP:0002078)3.03680760
31Dysmetria (HP:0001310)2.99344835
32Obstructive sleep apnea (HP:0002870)2.92678762
33Progressive inability to walk (HP:0002505)2.90736237
34Insidious onset (HP:0003587)2.90091437
35Termporal pattern (HP:0011008)2.90091437
36Scanning speech (HP:0002168)2.85117373
37Broad-based gait (HP:0002136)2.83517205
38Abnormality of the corticospinal tract (HP:0002492)2.82206500
39Papilledema (HP:0001085)2.69816626
40Hyperventilation (HP:0002883)2.69724198
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.64721958
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.64721958
43Limb dystonia (HP:0002451)2.64660571
44Pheochromocytoma (HP:0002666)2.63399638
45Urinary bladder sphincter dysfunction (HP:0002839)2.62500487
46Intention tremor (HP:0002080)2.60218262
47Gaze-evoked nystagmus (HP:0000640)2.59500591
48Dysmetric saccades (HP:0000641)2.58842855
49Anxiety (HP:0000739)2.57275506
50Mutism (HP:0002300)2.56344595
51Spastic gait (HP:0002064)2.56204992
52Amblyopia (HP:0000646)2.54325151
53Bronchitis (HP:0012387)2.52914872
54Exotropia (HP:0000577)2.48355684
55Abnormal eating behavior (HP:0100738)2.47825823
56Dysdiadochokinesis (HP:0002075)2.47440087
57Recurrent sinusitis (HP:0011108)2.47123752
58Depression (HP:0000716)2.47046506
59Decreased circulating renin level (HP:0003351)2.45734052
60Urinary urgency (HP:0000012)2.45511879
61Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.44272735
62Ventricular fibrillation (HP:0001663)2.42902900
63Peripheral hypomyelination (HP:0007182)2.42139553
64Agitation (HP:0000713)2.39273176
65Postural instability (HP:0002172)2.37962297
66Diplopia (HP:0000651)2.37587738
67Abnormality of binocular vision (HP:0011514)2.37587738
68Recurrent otitis media (HP:0000403)2.36153494
69Impaired vibration sensation in the lower limbs (HP:0002166)2.35848452
70Drooling (HP:0002307)2.34632109
71Excessive salivation (HP:0003781)2.34632109
72Ulnar claw (HP:0001178)2.32547452
73Hyperkalemia (HP:0002153)2.29229514
74Neuroendocrine neoplasm (HP:0100634)2.28333609
75Poor eye contact (HP:0000817)2.28251922
76Abnormal social behavior (HP:0012433)2.24868392
77Impaired social interactions (HP:0000735)2.24868392
78Abnormality of renin-angiotensin system (HP:0000847)2.22077279
79Hyperaldosteronism (HP:0000859)2.21786844
80Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.20742856
81Interstitial pulmonary disease (HP:0006530)2.20179209
82Hypothermia (HP:0002045)2.18344152
83Neuronal loss in central nervous system (HP:0002529)2.15726122
84Genetic anticipation (HP:0003743)2.14962897
85Blue irides (HP:0000635)2.14361425
86Syncope (HP:0001279)2.12463572
87Rapidly progressive (HP:0003678)2.10687513
88Onion bulb formation (HP:0003383)2.10627679
89Psychosis (HP:0000709)2.09589404
90Akinesia (HP:0002304)2.09348288
91Eczematoid dermatitis (HP:0000976)2.07616022
92Failure to thrive in infancy (HP:0001531)2.07374913
93Hyperthyroidism (HP:0000836)2.05619104
94Chronic otitis media (HP:0000389)2.01072275
95Lower limb muscle weakness (HP:0007340)2.00478210
96Plantar hyperkeratosis (HP:0007556)2.00122748
97Increased IgE level (HP:0003212)1.99877754
98Polyphagia (HP:0002591)1.98911789
99Milia (HP:0001056)1.98557902
100Malnutrition (HP:0004395)1.98011923
101Hypoplasia of dental enamel (HP:0006297)1.97358405
102Chronic sinusitis (HP:0011109)1.95627341
103Increased CSF protein (HP:0002922)1.94841425
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.94154511
105Onycholysis (HP:0001806)1.93559510
106Parakeratosis (HP:0001036)1.92307153
107Sensory axonal neuropathy (HP:0003390)1.90501906
108Abnormality of chloride homeostasis (HP:0011422)1.89481203
109Recurrent bronchitis (HP:0002837)1.89472446
110Epileptiform EEG discharges (HP:0011182)1.89094681
111Inability to walk (HP:0002540)1.88364965
112Stereotypic behavior (HP:0000733)1.87970760
113Growth hormone excess (HP:0000845)1.86364696
114Generalized myoclonic seizures (HP:0002123)1.85180708
115Dysostosis multiplex (HP:0000943)1.84101391
116Retinal dysplasia (HP:0007973)1.83675430
117Abnormality of salivation (HP:0100755)1.83168930
118Absent speech (HP:0001344)1.82297246
119Hypoventilation (HP:0002791)1.80606700
120Cerebral hemorrhage (HP:0001342)1.80485645
121Autoamputation (HP:0001218)1.80423304
122Rigidity (HP:0002063)1.80260277
123Segmental peripheral demyelination/remyelination (HP:0003481)1.80043890
124Thick nail (HP:0001805)1.79903029
125Urinary glycosaminoglycan excretion (HP:0003541)1.79863087
126Mucopolysacchariduria (HP:0008155)1.79863087
127Abnormality of saccadic eye movements (HP:0000570)1.79599289
128EEG with generalized epileptiform discharges (HP:0011198)1.79052904
129Infertility (HP:0000789)1.78995901
130Slow saccadic eye movements (HP:0000514)1.78919904
131Megalencephaly (HP:0001355)1.78487696
132Adrenal overactivity (HP:0002717)1.78002774
133Hyperparathyroidism (HP:0000843)1.77868156
134Renal salt wasting (HP:0000127)1.77774532
135Glucose intolerance (HP:0000833)1.76576843
136Widely spaced teeth (HP:0000687)1.76077917
137Palmoplantar hyperkeratosis (HP:0000972)1.75574776
138Gait ataxia (HP:0002066)1.75349496
139Right ventricular cardiomyopathy (HP:0011663)1.74426362
140Bradycardia (HP:0001662)1.72864563
141Metabolic alkalosis (HP:0200114)1.72762601
142Inappropriate behavior (HP:0000719)1.71976186
143Abnormality of calcium-phosphate metabolism (HP:0100530)1.71924215
144Male infertility (HP:0003251)1.71716234
145Abnormality of nail color (HP:0100643)1.71613360
146Hypercortisolism (HP:0001578)1.70850845
147Abnormality of mucopolysaccharide metabolism (HP:0011020)1.70821255
148Abnormality of polysaccharide metabolism (HP:0011012)1.70821255
149Abnormality of glycosaminoglycan metabolism (HP:0004371)1.70821255
150Thickened helices (HP:0000391)1.70500461
151Bradykinesia (HP:0002067)1.69526439
152Torticollis (HP:0000473)1.68704432
153Abnormality of the periventricular white matter (HP:0002518)1.68410040
154Impaired smooth pursuit (HP:0007772)1.68044402
155Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.67823883
156Lip pit (HP:0100267)1.66984095
157Decreased motor nerve conduction velocity (HP:0003431)1.65032818
158Pili torti (HP:0003777)1.62619890
159Broad face (HP:0000283)1.62294572
160Abnormality of the axillary hair (HP:0100134)1.61077651
161Abnormality of secondary sexual hair (HP:0009888)1.61077651
162Increased cerebral lipofuscin (HP:0011813)1.60840182
163Abnormal glucose tolerance (HP:0001952)1.60415353

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.82924229
2NTRK33.71660615
3EPHA42.73027618
4MAP3K42.61956360
5MAP3K122.56287649
6RIPK12.20996429
7MAP3K22.18074943
8MAP2K72.15390124
9NTRK12.11221005
10MINK12.04983069
11MARK12.03289599
12KSR22.03034191
13RIPK42.01390730
14STK391.92957505
15MAPK151.84309036
16CASK1.84080031
17MAP2K41.69223498
18EPHA21.67856633
19OXSR11.64185253
20DAPK21.59669868
21MAP3K31.58579263
22JAK11.55030625
23GRK51.54402234
24NTRK21.53082303
25MAPKAPK51.51115020
26CDK191.49423904
27PAK61.46162332
28MAPKAPK31.44518039
29MAP3K131.41403079
30CDK51.40833718
31TNIK1.33657352
32ERN11.32067882
33PNCK1.28319660
34STK241.27359046
35TRIB31.25880946
36LMTK21.22931479
37FGFR31.22745134
38RET1.18672408
39CAMKK11.16604521
40ARAF1.16434717
41TAOK21.15424671
42FER1.13651252
43NEK61.12093447
44CAMK2A1.11424300
45CAMK2B1.10293525
46TRPM71.09275135
47WNK11.09017543
48MAP3K111.08932704
49CAMKK21.07443648
50SGK4941.07300010
51SGK2231.07300010
52NLK1.05792291
53CSK1.04677938
54PAK31.03352462
55MAP3K141.01433118
56MAPK121.00650881
57FES1.00425853
58MAPK130.98829389
59MST40.98139059
60CDK120.97779003
61MAP3K10.97495574
62PLK20.96580147
63SIK20.93323614
64CSNK1G20.92985738
65BMPR20.91382610
66FGR0.91068139
67PHKG20.90935294
68PHKG10.90935294
69WNK40.90761955
70CAMK1G0.89919671
71UHMK10.89910266
72CAMK2D0.88321094
73GRK70.87239434
74PRKCH0.85878569
75MATK0.85374402
76KSR10.84194780
77PRKCE0.83151816
78STK110.82508257
79FRK0.80787149
80EPHB10.80576653
81ITK0.79421685
82PRKD30.78880713
83TESK10.78720334
84CDC42BPA0.78388635
85FGFR40.77083405
86PRKCG0.75707046
87SIK10.75603943
88TYK20.75277751
89PKN10.75213510
90MARK20.73467697
91STK380.73138417
92PDPK10.70858419
93PTK2B0.69939040
94TNK20.69355246
95CAMK2G0.68988498
96CAMK10.68351108
97JAK20.67940345
98DAPK10.67315277
99MAP4K10.66688956
100ERBB20.66119386
101NME10.65787527
102AKT30.65195191
103SGK10.63520465
104ZAP700.63091425
105FGFR20.62579271
106EEF2K0.62383209
107ROCK20.62346588
108SGK20.61418197
109BCR0.61071662
110PDK10.59882067
111EPHA30.59628008
112BLK0.58862319
113FYN0.57701874
114PDGFRB0.57252742
115SGK30.57060820
116HIPK20.56185338
117MAP3K70.55999239
118MAP2K60.55684175
119CDK140.55187458
120TBK10.53723833
121PRPF4B0.52587079
122CDK180.52510953
123CDK150.52165323
124DYRK1A0.51758640
125MAP2K10.50734405
126MAP2K30.50679682
127MST1R0.50169364
128MAPK70.49626599
129SCYL20.49504732
130TYRO30.49472509
131MAPK100.49015372
132PRKCQ0.48268370
133ALK0.48243817
134SYK0.47646716
135LATS20.47420985
136CSNK1G30.47361304
137CAMK1D0.47117206
138DMPK0.46789410
139TAOK10.46341665
140RAF10.43091834
141CDK11A0.42023300
142BMPR1B0.41103524
143PRKD10.40271013
144RPS6KA20.39528749
145TAOK30.38126981

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.78863300
2Synaptic vesicle cycle_Homo sapiens_hsa047212.66792742
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.19689562
4Olfactory transduction_Homo sapiens_hsa047402.19547384
5Long-term potentiation_Homo sapiens_hsa047202.10823761
6GABAergic synapse_Homo sapiens_hsa047272.09730961
7Circadian entrainment_Homo sapiens_hsa047132.06875530
8Glutamatergic synapse_Homo sapiens_hsa047242.06440361
9Salivary secretion_Homo sapiens_hsa049701.99733205
10Amphetamine addiction_Homo sapiens_hsa050311.98754453
11Morphine addiction_Homo sapiens_hsa050321.95191644
12Dopaminergic synapse_Homo sapiens_hsa047281.86160592
13Gastric acid secretion_Homo sapiens_hsa049711.84830735
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.83459083
15Collecting duct acid secretion_Homo sapiens_hsa049661.79284677
16Serotonergic synapse_Homo sapiens_hsa047261.76583200
17Taste transduction_Homo sapiens_hsa047421.74339235
18Renin secretion_Homo sapiens_hsa049241.70950984
19Insulin secretion_Homo sapiens_hsa049111.69613418
20Cholinergic synapse_Homo sapiens_hsa047251.64408227
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.56490633
22Long-term depression_Homo sapiens_hsa047301.55599045
23Cocaine addiction_Homo sapiens_hsa050301.55519106
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.43353278
25Histidine metabolism_Homo sapiens_hsa003401.39341061
26Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37374126
27Oxytocin signaling pathway_Homo sapiens_hsa049211.35434299
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.35347343
29GnRH signaling pathway_Homo sapiens_hsa049121.34230091
30Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29950550
31Vibrio cholerae infection_Homo sapiens_hsa051101.29686297
32Calcium signaling pathway_Homo sapiens_hsa040201.29591569
33Pancreatic secretion_Homo sapiens_hsa049721.27806827
34Phosphatidylinositol signaling system_Homo sapiens_hsa040701.24898136
35Axon guidance_Homo sapiens_hsa043601.12878633
36Type II diabetes mellitus_Homo sapiens_hsa049301.11014931
37cAMP signaling pathway_Homo sapiens_hsa040241.08728898
38Gap junction_Homo sapiens_hsa045401.07833244
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.04645847
40Circadian rhythm_Homo sapiens_hsa047101.04624229
41Type I diabetes mellitus_Homo sapiens_hsa049401.04499716
42Dorso-ventral axis formation_Homo sapiens_hsa043201.04013126
43B cell receptor signaling pathway_Homo sapiens_hsa046621.02986712
44Estrogen signaling pathway_Homo sapiens_hsa049151.02433451
45Vascular smooth muscle contraction_Homo sapiens_hsa042701.01272854
46ErbB signaling pathway_Homo sapiens_hsa040120.97127814
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96443848
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.92430455
49Phototransduction_Homo sapiens_hsa047440.90911229
50Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90811430
51Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.90135967
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.86593437
53Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.85501770
54Melanogenesis_Homo sapiens_hsa049160.84726725
55Glioma_Homo sapiens_hsa052140.84704497
56Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.82082538
57Leukocyte transendothelial migration_Homo sapiens_hsa046700.81498418
58Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78065855
59mTOR signaling pathway_Homo sapiens_hsa041500.77821065
60Sphingolipid signaling pathway_Homo sapiens_hsa040710.77702361
61Phospholipase D signaling pathway_Homo sapiens_hsa040720.77271919
62Graft-versus-host disease_Homo sapiens_hsa053320.76882242
63Allograft rejection_Homo sapiens_hsa053300.76822485
64Autoimmune thyroid disease_Homo sapiens_hsa053200.76536652
65Osteoclast differentiation_Homo sapiens_hsa043800.76513970
66Cardiac muscle contraction_Homo sapiens_hsa042600.75794689
67Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.75707400
68Thyroid hormone synthesis_Homo sapiens_hsa049180.75393553
69Hepatitis C_Homo sapiens_hsa051600.71773385
70VEGF signaling pathway_Homo sapiens_hsa043700.71282493
71Inositol phosphate metabolism_Homo sapiens_hsa005620.70406485
72Acute myeloid leukemia_Homo sapiens_hsa052210.69875807
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69818234
74MAPK signaling pathway_Homo sapiens_hsa040100.69609119
75Tuberculosis_Homo sapiens_hsa051520.68184883
76Ras signaling pathway_Homo sapiens_hsa040140.67488930
77Choline metabolism in cancer_Homo sapiens_hsa052310.67043467
78Mineral absorption_Homo sapiens_hsa049780.65210123
79Dilated cardiomyopathy_Homo sapiens_hsa054140.64525414
80Toxoplasmosis_Homo sapiens_hsa051450.64331917
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63805716
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63636256
83Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63390141
84Phenylalanine metabolism_Homo sapiens_hsa003600.63309329
85Leishmaniasis_Homo sapiens_hsa051400.63250920
86Non-small cell lung cancer_Homo sapiens_hsa052230.63193676
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62997978
88Endocytosis_Homo sapiens_hsa041440.61476833
89ABC transporters_Homo sapiens_hsa020100.61332684
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.59015955
91Rheumatoid arthritis_Homo sapiens_hsa053230.58608192
92TNF signaling pathway_Homo sapiens_hsa046680.58268418
93Alzheimers disease_Homo sapiens_hsa050100.57539645
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57121829
95Amoebiasis_Homo sapiens_hsa051460.56699871
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56571390
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.56549153
98Neurotrophin signaling pathway_Homo sapiens_hsa047220.56129058
99Insulin resistance_Homo sapiens_hsa049310.55227571
100Rap1 signaling pathway_Homo sapiens_hsa040150.54734872
101Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53625648
102Sphingolipid metabolism_Homo sapiens_hsa006000.52944298
103Renal cell carcinoma_Homo sapiens_hsa052110.52142558
104Ether lipid metabolism_Homo sapiens_hsa005650.51230019
105Fatty acid biosynthesis_Homo sapiens_hsa000610.50418278
106Chemokine signaling pathway_Homo sapiens_hsa040620.49656201
107Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43804888
108Ovarian steroidogenesis_Homo sapiens_hsa049130.43413040
109Prolactin signaling pathway_Homo sapiens_hsa049170.43015105
110Platelet activation_Homo sapiens_hsa046110.42200630
111Oxidative phosphorylation_Homo sapiens_hsa001900.42187706
112Phagosome_Homo sapiens_hsa041450.41554720
113Sulfur metabolism_Homo sapiens_hsa009200.41414885
114Bile secretion_Homo sapiens_hsa049760.41238841
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41174803
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.41065471
117T cell receptor signaling pathway_Homo sapiens_hsa046600.38860909
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38142485
119African trypanosomiasis_Homo sapiens_hsa051430.37636236
120Endometrial cancer_Homo sapiens_hsa052130.37291116
121Tight junction_Homo sapiens_hsa045300.36926374
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.36107866
123Glycerophospholipid metabolism_Homo sapiens_hsa005640.34511579
124Lysosome_Homo sapiens_hsa041420.34184443
125Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33963690
126Salmonella infection_Homo sapiens_hsa051320.33307563
127Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32947959

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