MFSD6L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)9.48009651
2Golgi transport vesicle coating (GO:0048200)9.48009651
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.67858360
4ovulation from ovarian follicle (GO:0001542)6.40152256
5peptide hormone processing (GO:0016486)6.10361956
6endocrine pancreas development (GO:0031018)6.03891603
7protein retention in ER lumen (GO:0006621)5.90440988
8retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)5.68852049
9signal peptide processing (GO:0006465)5.52489101
10regulation of apoptotic process involved in morphogenesis (GO:1902337)5.45773825
11protein maturation by protein folding (GO:0022417)5.33987256
12negative regulation of metanephros development (GO:0072217)5.30153362
13COPII vesicle coating (GO:0048208)5.22181667
14sequestering of metal ion (GO:0051238)5.01051938
15regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.93761201
16intestinal absorption (GO:0050892)4.83190811
17glandular epithelial cell differentiation (GO:0002067)4.80969872
18negative regulation of neurological system process (GO:0031645)4.75632651
19poly(A)+ mRNA export from nucleus (GO:0016973)4.71916186
20regulation of type B pancreatic cell apoptotic process (GO:2000674)4.65426325
21nephron tubule formation (GO:0072079)4.58695776
22ER overload response (GO:0006983)4.42999283
23response to protozoan (GO:0001562)4.41629816
24oligosaccharide catabolic process (GO:0009313)4.34184957
25ovulation (GO:0030728)4.29808702
26calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.27911471
27activation of signaling protein activity involved in unfolded protein response (GO:0006987)4.26644488
28regulation of axon regeneration (GO:0048679)4.22680575
29regulation of neuron projection regeneration (GO:0070570)4.22680575
30positive regulation of insulin secretion (GO:0032024)4.20977098
31angiotensin maturation (GO:0002003)4.17617021
32intestinal cholesterol absorption (GO:0030299)4.08803998
33regulation of extracellular matrix disassembly (GO:0010715)4.07238593
34auditory receptor cell differentiation (GO:0042491)4.07136236
35ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)4.07051433
36exocrine pancreas development (GO:0031017)4.06009493
37positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.05209698
38positive regulation of nuclease activity (GO:0032075)4.04550428
39vesicle coating (GO:0006901)4.04301198
40negative regulation of cell killing (GO:0031342)4.01277611
41negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01277611
42regulation of bile acid biosynthetic process (GO:0070857)3.92262836
43positive regulation of glycolytic process (GO:0045821)3.89876618
44insulin secretion (GO:0030073)3.87428357
45axonemal dynein complex assembly (GO:0070286)3.86925659
46response to hydroperoxide (GO:0033194)3.82925337
47macroautophagy (GO:0016236)3.69247123
48ncRNA 3-end processing (GO:0043628)3.68572536
49regulation of nuclease activity (GO:0032069)3.67940614
50endoplasmic reticulum unfolded protein response (GO:0030968)3.64442615
51cellular response to unfolded protein (GO:0034620)3.63254902
52negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.63101371
53branching involved in labyrinthine layer morphogenesis (GO:0060670)3.61642634
54N-acetylneuraminate metabolic process (GO:0006054)3.56505254
55purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.54307072
563-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.54307072
57cellular response to topologically incorrect protein (GO:0035967)3.51852180
58heme transport (GO:0015886)3.48827840
59regulation of uterine smooth muscle contraction (GO:0070472)3.48367766
60ribosomal small subunit biogenesis (GO:0042274)3.45601733
61sperm motility (GO:0030317)3.44000056
62positive regulation of uterine smooth muscle contraction (GO:0070474)3.42776951
63neuromuscular process controlling posture (GO:0050884)3.41492082
64regulation of insulin secretion (GO:0050796)3.41248953
65ER-nucleus signaling pathway (GO:0006984)3.39945710
66L-alpha-amino acid transmembrane transport (GO:1902475)3.36620711
67regulation of glucocorticoid secretion (GO:2000849)3.35995600
68positive regulation of peptide hormone secretion (GO:0090277)3.35484640
69positive regulation of interferon-alpha production (GO:0032727)3.34202840
70regulation of interferon-beta biosynthetic process (GO:0045357)3.33340418
71columnar/cuboidal epithelial cell development (GO:0002066)3.30860794
72intestinal epithelial cell development (GO:0060576)3.30809788
73glandular epithelial cell development (GO:0002068)3.27177300
74negative regulation of insulin secretion (GO:0046676)3.26830389
75membrane protein intracellular domain proteolysis (GO:0031293)3.26345000
76positive regulation of cholesterol transport (GO:0032376)3.25403208
77positive regulation of sterol transport (GO:0032373)3.25403208
78cellular ketone body metabolic process (GO:0046950)3.24821431
79intra-Golgi vesicle-mediated transport (GO:0006891)3.24793472
80negative regulation of execution phase of apoptosis (GO:1900118)3.23011730
81potassium ion export (GO:0071435)3.22479978
82regulation of systemic arterial blood pressure by hormone (GO:0001990)3.21773855
83regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)3.21773855
84endocrine process (GO:0050886)3.21773855
85peptidyl-asparagine modification (GO:0018196)3.21176603
86regulation of mesenchymal cell apoptotic process (GO:2001053)3.21165147
87protein N-linked glycosylation via asparagine (GO:0018279)3.21030457
88growth hormone secretion (GO:0030252)3.20587569
89positive regulation of peptide secretion (GO:0002793)3.18998257
90peptide hormone secretion (GO:0030072)3.18535492
91atrial cardiac muscle cell action potential (GO:0086014)3.18378627
92positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)3.16165863
93sexual reproduction (GO:0019953)3.15327345
94peptide secretion (GO:0002790)3.13720846
95peptide catabolic process (GO:0043171)3.13654428
96keratinocyte proliferation (GO:0043616)3.12430539
97type B pancreatic cell development (GO:0003323)3.12291808
98positive regulation of cholesterol efflux (GO:0010875)3.11804718
99cilium or flagellum-dependent cell motility (GO:0001539)3.10928795
100ER to Golgi vesicle-mediated transport (GO:0006888)3.10554687
101regulation of interferon-alpha production (GO:0032647)3.10034149
102regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.09721106
103regulation of peptide hormone secretion (GO:0090276)3.09150115
104response to endoplasmic reticulum stress (GO:0034976)3.08746431
105cellular response to vitamin D (GO:0071305)3.08515255
106UDP-N-acetylglucosamine metabolic process (GO:0006047)3.08026885
107inner ear receptor cell differentiation (GO:0060113)3.07755812
108GDP-mannose metabolic process (GO:0019673)3.07432626
109positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.04559546
110negative regulation of glycoprotein biosynthetic process (GO:0010561)3.04302297
111peptide transport (GO:0015833)3.03781366
112negative regulation of fatty acid transport (GO:2000192)3.03210136
113toxin metabolic process (GO:0009404)3.02991802
114positive regulation of neurotransmitter secretion (GO:0001956)3.02418725
115regulation of peptide secretion (GO:0002791)3.02275798
116negative regulation of transcription by competitive promoter binding (GO:0010944)3.01874129
117fusion of sperm to egg plasma membrane (GO:0007342)3.00935791
118parental behavior (GO:0060746)2.99649764
119cellular response to type I interferon (GO:0071357)2.99419772
120type I interferon signaling pathway (GO:0060337)2.99419772
121nitric oxide mediated signal transduction (GO:0007263)2.99279103
122protein N-linked glycosylation (GO:0006487)2.97656128
123production of molecular mediator involved in inflammatory response (GO:0002532)2.96909306
124response to unfolded protein (GO:0006986)2.95586878
125response to type I interferon (GO:0034340)2.95269164
126amyloid precursor protein catabolic process (GO:0042987)2.95197949
127regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.94328937
128negative regulation of kidney development (GO:0090185)2.93580300
129pyrimidine dimer repair (GO:0006290)2.93282020
130regulation of podosome assembly (GO:0071801)2.90652406
131nephron tubule development (GO:0072080)2.90623748
132keratinocyte development (GO:0003334)2.90517506
133NAD biosynthetic process (GO:0009435)2.90158572
134regulation of stem cell maintenance (GO:2000036)2.89734669
135iron coordination entity transport (GO:1901678)2.88476065
136regulation of cell fate specification (GO:0042659)2.88467345
137positive regulation of p38MAPK cascade (GO:1900745)2.88415345
138acrosome assembly (GO:0001675)2.88164839
139protein localization to Golgi apparatus (GO:0034067)2.87410269
140response to topologically incorrect protein (GO:0035966)2.85600296
141labyrinthine layer development (GO:0060711)2.84983641
142digestive system process (GO:0022600)2.84557262
143positive regulation of cellular amide metabolic process (GO:0034250)2.81586483
144carnitine metabolic process (GO:0009437)2.81332099
145ethanol oxidation (GO:0006069)2.81118139
146ketone body metabolic process (GO:1902224)2.80900663
147reproduction (GO:0000003)2.80122441
148interleukin-1-mediated signaling pathway (GO:0070498)2.79145186
149modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78317653
150positive regulation by organism of defense response of other organism involved in symbiotic interact2.78317653
151modulation by symbiont of host immune response (GO:0052553)2.78317653
152positive regulation by symbiont of host defense response (GO:0052509)2.78317653
153modulation by symbiont of host defense response (GO:0052031)2.78317653
154modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78317653
155regulation of inositol phosphate biosynthetic process (GO:0010919)2.78046351
156negative regulation of peptide hormone secretion (GO:0090278)2.76662627
157negative regulation of bone resorption (GO:0045779)2.76038968
158determination of left/right symmetry (GO:0007368)2.75294135
159primary alcohol catabolic process (GO:0034310)2.74764562
160piRNA metabolic process (GO:0034587)2.74681540
161response to interferon-beta (GO:0035456)2.74467301
162regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73260929
163regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.72222847
164response to interferon-alpha (GO:0035455)2.71926471
165microtubule severing (GO:0051013)2.70843077
166negative regulation of peptide secretion (GO:0002792)2.70171495
167multicellular organism reproduction (GO:0032504)2.70063897
168interferon-gamma secretion (GO:0072643)2.68826138
169hormone catabolic process (GO:0042447)2.68305805
170amino-acid betaine metabolic process (GO:0006577)2.67848001
171peptide metabolic process (GO:0006518)2.67754538
172antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.67715398
173decidualization (GO:0046697)2.66350705
174angiogenesis involved in wound healing (GO:0060055)2.65753723
175regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)2.65349136
176glucose 6-phosphate metabolic process (GO:0051156)2.65219637
177negative regulation of cAMP-mediated signaling (GO:0043951)2.65122358
178acrosome reaction (GO:0007340)2.64606089
179cell redox homeostasis (GO:0045454)2.64307675
180axoneme assembly (GO:0035082)2.64127591
181Golgi organization (GO:0007030)2.64036734
182sperm-egg recognition (GO:0035036)2.63702949
183adenosine metabolic process (GO:0046085)2.63385206
184response to hexose (GO:0009746)2.63185105
185glycerol ether metabolic process (GO:0006662)2.62557743
186response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.61461240
187response to host immune response (GO:0052572)2.61461240
188amino sugar catabolic process (GO:0046348)2.61148577
189regulation of hormone secretion (GO:0046883)2.60646884
190renal tubule development (GO:0061326)2.60172736
191amide transport (GO:0042886)2.59620802
192protein targeting to Golgi (GO:0000042)2.59449108
193spermatid development (GO:0007286)2.58910877
194positive regulation of fatty acid biosynthetic process (GO:0045723)2.58303286
195adhesion of symbiont to host cell (GO:0044650)2.58002340

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse8.38353795
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.41626608
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.09747777
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.09747777
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.09747777
6GATA1_22025678_ChIP-Seq_K562_Human3.67181674
7SOX2_27498859_Chip-Seq_STOMACH_Mouse2.69824939
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.69294744
9DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.65703741
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.54496555
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.29868170
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.14287722
13ESR1_21235772_ChIP-Seq_MCF-7_Human2.05774149
14BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.03613343
15STAT1_20625510_ChIP-Seq_HELA_Human1.87201594
16TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81182999
17STAT6_21828071_ChIP-Seq_BEAS2B_Human1.80677234
18IGF1R_20145208_ChIP-Seq_DFB_Human1.76587522
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73748360
20GATA4_25053715_ChIP-Seq_YYC3_Human1.73462060
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.68931439
22IRF8_27001747_Chip-Seq_BMDM_Mouse1.68805325
23ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.66945856
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.64843651
25MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64009425
26PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62835124
27VDR_22108803_ChIP-Seq_LS180_Human1.55487096
28Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54656171
29FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.53696607
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.51054448
31EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.46006844
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.43347253
33TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42896660
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42301689
35NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41564205
36PPARA_22158963_ChIP-Seq_LIVER_Mouse1.41212528
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41144454
38GATA6_25053715_ChIP-Seq_YYC3_Human1.41142630
39EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.41106630
40LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.40943880
41ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.40376891
42RXR_22158963_ChIP-Seq_LIVER_Mouse1.39234874
43FOXA1_25552417_ChIP-Seq_VCAP_Human1.37864707
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36709955
45GATA1_19941826_ChIP-Seq_K562_Human1.33786102
46TP63_17297297_ChIP-ChIP_HaCaT_Human1.31430432
47SRY_22984422_ChIP-ChIP_TESTIS_Rat1.31241037
48GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.29920166
49* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.29156730
50PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28978680
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.28271802
52SOX2_20726797_ChIP-Seq_SW620_Human1.27067347
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.25228193
54BMI1_23680149_ChIP-Seq_NPCS_Mouse1.24669515
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.24361719
56STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23830811
57GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22611213
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.22480008
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21286006
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.21122586
61IRF8_21731497_ChIP-ChIP_J774_Mouse1.20518458
62GATA2_21666600_ChIP-Seq_HMVEC_Human1.19313273
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19233449
64LXR_22292898_ChIP-Seq_THP-1_Human1.18874757
65GATA3_27048872_Chip-Seq_THYMUS_Human1.18452057
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17861399
67ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17737912
68RUNX1_27514584_Chip-Seq_MCF-7_Human1.17226356
69CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.15949376
70MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15802856
71SPI1_23127762_ChIP-Seq_K562_Human1.15391020
72STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15023258
73FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.14576018
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.14363275
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.14352448
76RXR_22108803_ChIP-Seq_LS180_Human1.12640109
77SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12519669
78BCAT_22108803_ChIP-Seq_LS180_Human1.12155110
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.11716077
80SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10819907
81SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10265715
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.10204672
83ERG_20517297_ChIP-Seq_VCAP_Human1.10164692
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09314188
85FOXO3_23340844_ChIP-Seq_DLD1_Human1.07320337
86FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.07232668
87TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.06475249
88IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05572834
89RARA_24833708_ChIP-Seq_LIVER_Mouse1.05207231
90EGR1_19032775_ChIP-ChIP_M12_Human1.04797714
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02976868
92GATA3_21867929_ChIP-Seq_CD8_Mouse1.02881304
93NOTCH1_21737748_ChIP-Seq_TLL_Human1.00681754
94ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.00297913
95VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.00207030
96* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99679719
97CDX2_20551321_ChIP-Seq_CACO-2_Human0.99204224
98TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99125986
99GATA3_26560356_Chip-Seq_TH2_Human0.98382761
100CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97987884
101* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97324705
102SMAD3_21741376_ChIP-Seq_HESCs_Human0.97296823
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96875037
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95686417
105GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.95539562
106* JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.95220035
107SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93989979
108VDR_24763502_ChIP-Seq_THP-1_Human0.93834088
109CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93805189
110ELF1_20517297_ChIP-Seq_JURKAT_Human0.93619201
111TFEB_21752829_ChIP-Seq_HELA_Human0.93062881
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.92678401
113FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92100526
114PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91834929
115SA1_27219007_Chip-Seq_Bcells_Human0.91249174
116SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.91149429
117BCOR_27268052_Chip-Seq_Bcells_Human0.90318001
118PHF8_20622854_ChIP-Seq_HELA_Human0.90023829
119FOXA2_19822575_ChIP-Seq_HepG2_Human0.89814869
120LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.89098917
121TET1_21451524_ChIP-Seq_MESCs_Mouse0.88979552
122MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88831209
123KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88548802
124RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.88303293
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88161625
126TBX20_22328084_ChIP-Seq_HEART_Mouse0.87374132
127TBX20_22080862_ChIP-Seq_HEART_Mouse0.87374132
128BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.86967277
129GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85105191
130ESR2_21235772_ChIP-Seq_MCF-7_Human0.84925709
131RUNX1_22412390_ChIP-Seq_EML_Mouse0.84367816
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.83808540
133TP63_22573176_ChIP-Seq_HFKS_Human0.83325387
134ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.82380137
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82177153
136ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.82155292
137IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.81895384
138NANOG_20526341_ChIP-Seq_ESCs_Human0.81524652
139NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.78827927
140NRF2_20460467_ChIP-Seq_MEFs_Mouse0.78827927
141CREB1_26743006_Chip-Seq_LNCaP_Human0.77190727
142BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.76785427
143ERA_21632823_ChIP-Seq_H3396_Human0.75452796
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73995403
145FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73936044
146PU.1_20513432_ChIP-Seq_Bcells_Mouse0.73541272
147CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.73523173
148VDR_21846776_ChIP-Seq_THP-1_Human0.72781494
149RACK7_27058665_Chip-Seq_MCF-7_Human0.72521631
150GATA3_21867929_ChIP-Seq_TH1_Mouse0.72308224
151SMAD4_21741376_ChIP-Seq_HESCs_Human0.71381650
152GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.70914850
153* P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.69098861
154GATA2_19941826_ChIP-Seq_K562_Human0.68566758
155TCF4_22108803_ChIP-Seq_LS180_Human0.68245295
156RARB_24833708_ChIP-Seq_LIVER_Mouse0.68217268
157ZNF263_19887448_ChIP-Seq_K562_Human0.67990139
158* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.67840192

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat4.81014535
2MP0002877_abnormal_melanocyte_morpholog4.62294770
3MP0003183_abnormal_peptide_metabolism4.53557139
4MP0004043_abnormal_pH_regulation4.38552360
5MP0003283_abnormal_digestive_organ4.19516667
6MP0009379_abnormal_foot_pigmentation4.03945537
7MP0002693_abnormal_pancreas_physiology3.75904142
8MP0004264_abnormal_extraembryonic_tissu3.56566826
9MP0004133_heterotaxia3.31666645
10MP0000013_abnormal_adipose_tissue3.27987545
11MP0001944_abnormal_pancreas_morphology3.01368319
12MP0010386_abnormal_urinary_bladder2.96758046
13MP0002909_abnormal_adrenal_gland2.95021161
14MP0003300_gastrointestinal_ulcer2.90669094
15MP0003195_calcinosis2.80823152
16MP0009780_abnormal_chondrocyte_physiolo2.75806085
17MP0005410_abnormal_fertilization2.69889843
18MP0000678_abnormal_parathyroid_gland2.61465085
19MP0002132_abnormal_respiratory_system2.59656882
20MP0005671_abnormal_response_to2.46244461
21MP0000015_abnormal_ear_pigmentation2.45914861
22MP0005220_abnormal_exocrine_pancreas2.32088239
23MP0001666_abnormal_nutrient_absorption2.31326147
24MP0000685_abnormal_immune_system2.05846384
25MP0000462_abnormal_digestive_system2.00870070
26MP0005379_endocrine/exocrine_gland_phen1.98726412
27MP0003172_abnormal_lysosome_physiology1.98020738
28MP0005310_abnormal_salivary_gland1.94637186
29MP0002078_abnormal_glucose_homeostasis1.94113512
30MP0003879_abnormal_hair_cell1.93812156
31MP0003866_abnormal_defecation1.90190099
32MP0002138_abnormal_hepatobiliary_system1.88787558
33MP0005058_abnormal_lysosome_morphology1.87078245
34MP0001765_abnormal_ion_homeostasis1.87022307
35MP0005409_darkened_coat_color1.85146604
36MP0000003_abnormal_adipose_tissue1.82421351
37MP0009643_abnormal_urine_homeostasis1.80934605
38MP0009785_altered_susceptibility_to1.79441906
39MP0002928_abnormal_bile_duct1.70212914
40MP0003252_abnormal_bile_duct1.68074753
41MP0005645_abnormal_hypothalamus_physiol1.64406963
42MP0005360_urolithiasis1.63990998
43MP0004883_abnormal_blood_vessel1.62080225
44MP0009840_abnormal_foam_cell1.58349638
45MP0008057_abnormal_DNA_replication1.56095275
46MP0001881_abnormal_mammary_gland1.49070410
47MP0002139_abnormal_hepatobiliary_system1.47091191
48MP0000566_synostosis1.45246144
49MP0004947_skin_inflammation1.43150233
50MP0008961_abnormal_basal_metabolism1.37078578
51MP0002837_dystrophic_cardiac_calcinosis1.37020127
52MP0005025_abnormal_response_to1.34986703
53MP0006072_abnormal_retinal_apoptosis1.33110133
54MP0005646_abnormal_pituitary_gland1.32113497
55MP0005377_hearing/vestibular/ear_phenot1.31758805
56MP0003878_abnormal_ear_physiology1.31758805
57MP0003436_decreased_susceptibility_to1.31586893
58MP0004782_abnormal_surfactant_physiolog1.20013701
59MP0003953_abnormal_hormone_level1.17593973
60MP0005257_abnormal_intraocular_pressure1.16342746
61MP0005365_abnormal_bile_salt1.16194258
62MP0005636_abnormal_mineral_homeostasis1.14992093
63MP0001986_abnormal_taste_sensitivity1.14025320
64MP0000538_abnormal_urinary_bladder1.12548879
65MP0005085_abnormal_gallbladder_physiolo1.10915265
66MP0003938_abnormal_ear_development1.10342076
67MP0006082_CNS_inflammation1.09106927
68MP0002896_abnormal_bone_mineralization1.07115049
69MP0002452_abnormal_antigen_presenting1.04887238
70MP0010155_abnormal_intestine_physiology1.04668282
71MP0001756_abnormal_urination1.04666845
72MP0004808_abnormal_hematopoietic_stem1.03875397
73MP0008875_abnormal_xenobiotic_pharmacok1.02141734
74MP0006054_spinal_hemorrhage1.02049570
75MP0005448_abnormal_energy_balance1.01165964
76MP0002234_abnormal_pharynx_morphology1.01030092
77MP0005076_abnormal_cell_differentiation0.99450770
78MP0001188_hyperpigmentation0.99225043
79MP0005164_abnormal_response_to0.98514254
80MP0000613_abnormal_salivary_gland0.98241987
81MP0002723_abnormal_immune_serum0.97073765
82MP0005464_abnormal_platelet_physiology0.96352374
83MP0002148_abnormal_hypersensitivity_rea0.95204444
84MP0001800_abnormal_humoral_immune0.94316420
85MP0003303_peritoneal_inflammation0.94051693
86MP0003045_fibrosis0.93610299
87MP0002876_abnormal_thyroid_physiology0.93018280
88MP0002118_abnormal_lipid_homeostasis0.92257582
89MP0000639_abnormal_adrenal_gland0.91982260
90MP0002089_abnormal_postnatal_growth/wei0.90595071
91MP0003959_abnormal_lean_body0.90152422
92MP0000627_abnormal_mammary_gland0.89077309
93MP0005167_abnormal_blood-brain_barrier0.88505014
94MP0000609_abnormal_liver_physiology0.84893074
95MP0010678_abnormal_skin_adnexa0.84176629
96MP0001919_abnormal_reproductive_system0.83777235
97MP0005381_digestive/alimentary_phenotyp0.82876950
98MP0001845_abnormal_inflammatory_respons0.82651643
99MP0002638_abnormal_pupillary_reflex0.81343120
100MP0003795_abnormal_bone_structure0.80797734
101MP0005083_abnormal_biliary_tract0.80638653
102MP0005375_adipose_tissue_phenotype0.80546750
103MP0000383_abnormal_hair_follicle0.79341941
104MP0010352_gastrointestinal_tract_polyps0.77459762
105MP0005084_abnormal_gallbladder_morpholo0.77272841
106MP0001929_abnormal_gametogenesis0.77253305
107MP0001819_abnormal_immune_cell0.76879160
108MP0005166_decreased_susceptibility_to0.76850190
109MP0005000_abnormal_immune_tolerance0.76370881
110MP0010234_abnormal_vibrissa_follicle0.76101711
111MP0001790_abnormal_immune_system0.75912145
112MP0005387_immune_system_phenotype0.75912145
113MP0009642_abnormal_blood_homeostasis0.75021196
114MP0001533_abnormal_skeleton_physiology0.75019778
115MP0002277_abnormal_respiratory_mucosa0.75000297
116MP0005535_abnormal_body_temperature0.74475941
117MP0003943_abnormal_hepatobiliary_system0.73210879
118MP0003868_abnormal_feces_composition0.72759386
119MP0005334_abnormal_fat_pad0.72712264
120MP0005584_abnormal_enzyme/coenzyme_acti0.71868335
121MP0002998_abnormal_bone_remodeling0.71221337
122MP0003936_abnormal_reproductive_system0.69819824
123MP0003698_abnormal_male_reproductive0.69407734
124MP0008469_abnormal_protein_level0.69146909
125MP0010329_abnormal_lipoprotein_level0.68821679
126MP0002420_abnormal_adaptive_immunity0.68585862
127MP0003453_abnormal_keratinocyte_physiol0.67891524
128MP0005174_abnormal_tail_pigmentation0.67687749
129MP0000604_amyloidosis0.67213454
130MP0000372_irregular_coat_pigmentation0.66781376
131MP0003724_increased_susceptibility_to0.65990745
132MP0004019_abnormal_vitamin_homeostasis0.65194329
133MP0001835_abnormal_antigen_presentation0.64981632
134MP0000230_abnormal_systemic_arterial0.64767808
135MP0001873_stomach_inflammation0.63899670
136MP0002971_abnormal_brown_adipose0.63705312
137MP0002177_abnormal_outer_ear0.63512108
138MP0002419_abnormal_innate_immunity0.62863198
139MP0001663_abnormal_digestive_system0.61836987
140MP0000681_abnormal_thyroid_gland0.61505773
141MP0001348_abnormal_lacrimal_gland0.60853758
142MP0000716_abnormal_immune_system0.60464434
143MP0003329_amyloid_beta_deposits0.60009832
144MP0005075_abnormal_melanosome_morpholog0.59532410
145MP0008004_abnormal_stomach_pH0.59285786
146MP0002405_respiratory_system_inflammati0.59017847
147MP0002136_abnormal_kidney_physiology0.57721484
148MP0002163_abnormal_gland_morphology0.55652601
149MP0004233_abnormal_muscle_weight0.55418343

Predicted human phenotypes

RankGene SetZ-score
1Hyperinsulinemic hypoglycemia (HP:0000825)6.56461373
2Hypoglycemic seizures (HP:0002173)6.23991351
3Symptomatic seizures (HP:0011145)6.16302886
4Chronic bronchitis (HP:0004469)5.90515370
5Hypoglycemic coma (HP:0001325)5.64612129
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.49372519
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.24774938
8Insulin-resistant diabetes mellitus (HP:0000831)4.20930810
9Decreased circulating renin level (HP:0003351)4.16321755
10Hyperactive renin-angiotensin system (HP:0000841)4.02103182
11Bile duct proliferation (HP:0001408)3.96202819
12Abnormal biliary tract physiology (HP:0012439)3.96202819
13Methylmalonic acidemia (HP:0002912)3.92767607
14Hyperglycemia (HP:0003074)3.90569345
15Late onset (HP:0003584)3.62976690
16Dysostosis multiplex (HP:0000943)3.52213146
17Urinary glycosaminoglycan excretion (HP:0003541)3.51568799
18Mucopolysacchariduria (HP:0008155)3.51568799
19Abnormal pancreas size (HP:0012094)3.45288150
20Abnormality of vitamin B metabolism (HP:0004340)3.37193329
21Ketoacidosis (HP:0001993)3.36575710
22Abnormality of calcium-phosphate metabolism (HP:0100530)3.35748264
23Abnormality of endocrine pancreas physiology (HP:0012093)3.31533261
24Abnormality of the pancreatic islet cells (HP:0006476)3.31533261
253-Methylglutaconic aciduria (HP:0003535)3.28637745
26Vacuolated lymphocytes (HP:0001922)3.25323493
27Generalized aminoaciduria (HP:0002909)3.23985282
28Abnormality of polysaccharide metabolism (HP:0011012)3.23855442
29Abnormality of glycosaminoglycan metabolism (HP:0004371)3.23855442
30Abnormality of mucopolysaccharide metabolism (HP:0011020)3.23855442
31Absent/shortened dynein arms (HP:0200106)3.17281885
32Dynein arm defect of respiratory motile cilia (HP:0012255)3.17281885
33Rhinitis (HP:0012384)3.14616433
34Abnormality of macrophages (HP:0004311)3.10694828
35Hypoplasia of the uterus (HP:0000013)3.08039347
36Abnormal respiratory motile cilium physiology (HP:0012261)3.07680474
37Large for gestational age (HP:0001520)3.07318353
38Villous atrophy (HP:0011473)3.07164975
39Abnormality of small intestinal villus morphology (HP:0011472)3.07164975
40Methylmalonic aciduria (HP:0012120)3.03904633
41Exertional dyspnea (HP:0002875)3.03235234
42Hypokalemic alkalosis (HP:0001949)3.02851462
43Hypokinesia (HP:0002375)3.00858800
44Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.00215844
45Abdominal distention (HP:0003270)2.99825056
46Fetal akinesia sequence (HP:0001989)2.91967601
47Nasal polyposis (HP:0100582)2.91312860
48Abnormality of chloride homeostasis (HP:0011422)2.90796886
49Micronodular cirrhosis (HP:0001413)2.90228064
50Insulin resistance (HP:0000855)2.87274697
51Chronic diarrhea (HP:0002028)2.86883979
52Hyperparathyroidism (HP:0000843)2.86351780
53Abnormality of vitamin metabolism (HP:0100508)2.82459497
54Abnormality of renin-angiotensin system (HP:0000847)2.81734280
55Bronchitis (HP:0012387)2.80339399
56Hyperkalemia (HP:0002153)2.80011491
57Albinism (HP:0001022)2.80004719
58Hypokalemia (HP:0002900)2.77782698
59Gastrointestinal infarctions (HP:0005244)2.76707956
60Glycosuria (HP:0003076)2.74898336
61Abnormality of urine glucose concentration (HP:0011016)2.74898336
62Abnormal respiratory epithelium morphology (HP:0012253)2.68696670
63Abnormal respiratory motile cilium morphology (HP:0005938)2.68696670
64Polyuria (HP:0000103)2.66625078
65Pancreatic islet-cell hyperplasia (HP:0004510)2.66453774
66Proximal tubulopathy (HP:0000114)2.64506002
67Stomach cancer (HP:0012126)2.61127909
68Abnormality of the vitamin B12 metabolism (HP:0004341)2.59220865
69Gastrointestinal inflammation (HP:0004386)2.58346582
70Bronchiectasis (HP:0002110)2.53222575
71Thoracolumbar scoliosis (HP:0002944)2.53021914
72Inflammation of the large intestine (HP:0002037)2.50928084
73Glucose intolerance (HP:0000833)2.50016540
74Abnormality of the nasal mucosa (HP:0000433)2.43765125
75Focal dystonia (HP:0004373)2.42134389
76Craniofacial dystonia (HP:0012179)2.40788556
77Retinal atrophy (HP:0001105)2.39235273
78Loss of speech (HP:0002371)2.37951747
79Hyperglycinemia (HP:0002154)2.37462005
80Conjugated hyperbilirubinemia (HP:0002908)2.35628495
81Spontaneous abortion (HP:0005268)2.33243455
82Aplasia/hypoplasia of the uterus (HP:0008684)2.32585463
83Intention tremor (HP:0002080)2.30877270
84Pancreatic cysts (HP:0001737)2.30560586
85Prolonged QT interval (HP:0001657)2.30525465
86Central scotoma (HP:0000603)2.29485696
87Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26390178
88Abnormal protein N-linked glycosylation (HP:0012347)2.26390178
89Abnormal protein glycosylation (HP:0012346)2.26390178
90Abnormal glycosylation (HP:0012345)2.26390178
91Abnormality of potassium homeostasis (HP:0011042)2.26170836
92Abnormality of T cell physiology (HP:0011840)2.24142110
93Hyperphosphatemia (HP:0002905)2.23838288
94Increased CSF protein (HP:0002922)2.23438027
95Abnormality of the lower motor neuron (HP:0002366)2.22725926
96Abnormal urine output (HP:0012590)2.21443913
97Resting tremor (HP:0002322)2.19310457
98Hypophosphatemia (HP:0002148)2.18413774
99Abnormality of renal excretion (HP:0011036)2.18053914
100Exocrine pancreatic insufficiency (HP:0001738)2.17694175
101Cerebral inclusion bodies (HP:0100314)2.16918305
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16365486
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16365486
104Hypochromic anemia (HP:0001931)2.14790880
105Abnormal delayed hypersensitivity skin test (HP:0002963)2.14456127
106Abnormal ciliary motility (HP:0012262)2.14092708
107Abnormality of aromatic amino acid family metabolism (HP:0004338)2.14090731
108Abnormality of the intrinsic pathway (HP:0010989)2.13213087
109Infertility (HP:0000789)2.12519089
110Protuberant abdomen (HP:0001538)2.10989881
111Sensorimotor neuropathy (HP:0007141)2.06838611
112Hypotension (HP:0002615)2.04008904
113Azoospermia (HP:0000027)2.03886729
114Thin bony cortex (HP:0002753)2.03641878
115Conical tooth (HP:0000698)2.02792192
116Neonatal death (HP:0003811)2.02571231
117Hyperaldosteronism (HP:0000859)2.02490080
118Basal ganglia calcification (HP:0002135)2.01322641
119Hyperuricemia (HP:0002149)2.01249874
120Increased purine levels (HP:0004368)2.01249874
121Abnormality of dicarboxylic acid metabolism (HP:0010995)2.01030520
122Dicarboxylic aciduria (HP:0003215)2.01030520
123Thyroid-stimulating hormone excess (HP:0002925)1.98709492
124Myocardial infarction (HP:0001658)1.98290020
125Menstrual irregularities (HP:0000858)1.97001097
126Impulsivity (HP:0100710)1.93680561
127Hypomagnesemia (HP:0002917)1.92412567
128Broad nasal tip (HP:0000455)1.91839548
129Abnormality of purine metabolism (HP:0004352)1.91773599
130Cystic liver disease (HP:0006706)1.91410603
131Diminished movement (HP:0002374)1.90492437
132Abnormality of the gastric mucosa (HP:0004295)1.90476961
133Adrenal overactivity (HP:0002717)1.90088584
134Acute hepatic failure (HP:0006554)1.89796298
135Cheilitis (HP:0100825)1.89477009
136Agitation (HP:0000713)1.89333633
137Fatigue (HP:0012378)1.88612136
138Gingival bleeding (HP:0000225)1.86514783
139Abnormality of glycine metabolism (HP:0010895)1.85359150
140Abnormality of serine family amino acid metabolism (HP:0010894)1.85359150
141Posterior subcapsular cataract (HP:0007787)1.84889258
142Gout (HP:0001997)1.84589170
143Osteomalacia (HP:0002749)1.83271030
144Ketosis (HP:0001946)1.83257333
145Polyphagia (HP:0002591)1.82318957
146Abnormal drinking behavior (HP:0030082)1.81781762
147Polydipsia (HP:0001959)1.81781762
148Recurrent abscess formation (HP:0002722)1.81050622
149Recurrent sinusitis (HP:0011108)1.80894984
150Eczematoid dermatitis (HP:0000976)1.80887340
151Increased IgM level (HP:0003496)1.80881522
152Aplasia/Hypoplasia involving the musculature (HP:0001460)1.80651313
153Hypochromic microcytic anemia (HP:0004840)1.80595310
154Stomatitis (HP:0010280)1.80264433
155Cardiomegaly (HP:0001640)1.78649774
156Abnormal glucose tolerance (HP:0001952)1.78489897
157Abnormality of alkaline phosphatase activity (HP:0004379)1.78194868
158Increased cerebral lipofuscin (HP:0011813)1.78116490
159Hypercortisolism (HP:0001578)1.77687088
160Abnormality of liposaccharide metabolism (HP:0010968)1.77324044
161Abnormality of glycosphingolipid metabolism (HP:0004343)1.77324044
162Abnormality of glycolipid metabolism (HP:0010969)1.77324044
163Polygenic inheritance (HP:0010982)1.77294095
164Renal salt wasting (HP:0000127)1.76412836
165Vasculitis (HP:0002633)1.75204872
166Alkalosis (HP:0001948)1.74736616
167Congenital sensorineural hearing impairment (HP:0008527)1.73851344
168Abnormal biliary tract morphology (HP:0012440)1.72920582
169Abnormal enzyme/coenzyme activity (HP:0012379)1.71642576
170Progressive sensorineural hearing impairment (HP:0000408)1.70736561
171Widely patent fontanelles and sutures (HP:0004492)1.69768420
172Type I transferrin isoform profile (HP:0003642)1.69483569
173Gingivitis (HP:0000230)1.68476877
174Recurrent bacterial skin infections (HP:0005406)1.68291951
175Congenital glaucoma (HP:0001087)1.67809671
176Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.67619463
177Increased neuronal autofluorescent lipopigment (HP:0002074)1.67157663
178Unilateral renal agenesis (HP:0000122)1.66982603
179Growth hormone excess (HP:0000845)1.65779609
180Prominent metopic ridge (HP:0005487)1.64613665
181Elevated alkaline phosphatase (HP:0003155)1.64599295

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K96.64052636
2PASK5.01491540
3INSRR4.66362570
4MAPK154.63392018
5PINK14.38452751
6ERN13.57529319
7PRKD33.02928558
8IRAK32.84367430
9STK242.68527239
10MAP3K22.62145279
11TAOK32.59283218
12TESK12.54856090
13FRK2.50288319
14HIPK22.45229950
15WNK42.25956659
16ACVR1B2.22219526
17SIK22.21925049
18PDK32.09010449
19PDK42.09010449
20TLK11.94961179
21MAP2K61.87533214
22TRPM71.83679999
23EPHA21.83478717
24IRAK21.66509470
25ARAF1.63253030
26BLK1.59372382
27IRAK11.57161988
28PTK61.56703260
29PIK3CG1.53999593
30IRAK41.49841892
31PDK21.49755059
32TYK21.48651518
33OXSR11.45747790
34EPHA31.43797891
35IKBKB1.43046068
36FGR1.42656484
37MAP2K21.41421680
38EPHB11.41270656
39FLT31.36614368
40DYRK1B1.25743243
41TNK21.25253842
42MELK1.22707351
43WNK31.22428648
44MAP4K11.19236108
45KSR21.17691430
46NME11.15391275
47ICK1.11032707
48RIPK41.09713314
49PTK21.09448477
50MET1.08194248
51TAOK11.07058771
52NEK91.01554553
53FGFR20.98257062
54MAP3K10.98039036
55NTRK10.96633599
56JAK30.93863956
57MAP3K140.93356002
58MAP3K120.91451143
59FGFR40.90959106
60MST40.89292262
61JAK20.88635705
62MATK0.88123279
63ABL20.85993069
64MAPKAPK30.85458623
65EIF2AK30.84969856
66STK30.83912092
67MAP3K70.83509400
68SMG10.83258971
69TXK0.80420863
70ZAP700.78300254
71JAK10.78224241
72MAP3K100.77865178
73CSK0.77517107
74PRKG20.76180355
75SCYL20.76046138
76TRIB30.75746806
77PDGFRB0.72857558
78PDGFRA0.72350287
79YES10.66439836
80CAMKK20.66021693
81PRKCI0.65651558
82GRK60.65284916
83BCKDK0.65019399
84TBK10.64501280
85MOS0.63823361
86RPS6KA20.63055479
87BCR0.62757705
88MST1R0.62756911
89RPS6KB20.60123868
90CDC42BPA0.58555356
91CHUK0.57975337
92MAP3K30.57438609
93BTK0.53636424
94IKBKE0.52738947
95LYN0.52409418
96PIM10.52206432
97PAK30.51983944
98RAF10.51291113
99STK38L0.50284140
100GRK70.50073105
101MAP3K130.50048148
102KSR10.49642722
103NLK0.49550538
104CSF1R0.49240535
105STK380.49197806
106MTOR0.48626030
107DYRK30.48311455
108ITK0.47619646
109PRKCQ0.46209786
110TNIK0.45291255
111FER0.43258614
112CAMK1G0.42511043
113PRKAA10.41676036
114TGFBR10.40389856
115STK100.40032468
116CAMK1D0.39600139
117ERBB20.39577443
118GSK3A0.39530800
119WNK10.38993216
120PRKCH0.38591808
121TEC0.38410850
122MAPK110.37565817
123PDPK10.36778918
124DMPK0.35748345
125PRKCE0.35601831
126FES0.34957275
127PDK10.34352249
128STK390.33827379
129BRSK20.33661280
130PIK3CA0.33595570
131LMTK20.33080597
132ADRBK20.32865353
133SIK10.32863650
134UHMK10.32841267
135BRAF0.32252529
136RPS6KA60.30523583
137NEK20.30073340
138ABL10.28615334
139CDK190.27265884
140MAPKAPK20.27202309
141NTRK20.26761889
142PRKD20.26492780
143FYN0.26161255
144EGFR0.26051591
145AKT30.26046866
146MARK30.25916150
147RET0.25779383
148TGFBR20.25386244
149EIF2AK10.25106600
150GRK10.24242128
151ALK0.23899091
152CAMKK10.22294127
153PRKCD0.21938021
154CSNK1A10.21667276
155ILK0.21047489
156INSR0.20513731
157CAMK2D0.20343620
158RPS6KC10.20185205

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.99416094
2Protein export_Homo sapiens_hsa030604.21712035
3Sulfur metabolism_Homo sapiens_hsa009203.89869655
4Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.37593892
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.89213849
6Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.64391441
7Carbohydrate digestion and absorption_Homo sapiens_hsa049732.63466131
8Sulfur relay system_Homo sapiens_hsa041222.46568213
9Fatty acid biosynthesis_Homo sapiens_hsa000612.41239131
10Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.37702269
11Insulin secretion_Homo sapiens_hsa049112.22504895
12Other glycan degradation_Homo sapiens_hsa005112.20996156
13Type II diabetes mellitus_Homo sapiens_hsa049302.14133323
14Fat digestion and absorption_Homo sapiens_hsa049752.12712638
15Graft-versus-host disease_Homo sapiens_hsa053322.11189790
16Selenocompound metabolism_Homo sapiens_hsa004501.92104305
17Vibrio cholerae infection_Homo sapiens_hsa051101.91380718
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.91136090
19Lysosome_Homo sapiens_hsa041421.85586115
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.84122534
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83007236
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.64393475
23Fatty acid elongation_Homo sapiens_hsa000621.62376303
24Vitamin B6 metabolism_Homo sapiens_hsa007501.62344594
25Allograft rejection_Homo sapiens_hsa053301.59113615
26Autoimmune thyroid disease_Homo sapiens_hsa053201.58928032
27African trypanosomiasis_Homo sapiens_hsa051431.58322427
28N-Glycan biosynthesis_Homo sapiens_hsa005101.53655460
29Renin-angiotensin system_Homo sapiens_hsa046141.52723286
30Folate biosynthesis_Homo sapiens_hsa007901.52505116
31Mineral absorption_Homo sapiens_hsa049781.45823881
32Sphingolipid metabolism_Homo sapiens_hsa006001.41133070
33Propanoate metabolism_Homo sapiens_hsa006401.39554404
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.34472480
35Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32764730
36Galactose metabolism_Homo sapiens_hsa000521.32676238
37Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.30792079
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28505149
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24652435
40Type I diabetes mellitus_Homo sapiens_hsa049401.23615041
41B cell receptor signaling pathway_Homo sapiens_hsa046621.19709763
42Nitrogen metabolism_Homo sapiens_hsa009101.19320095
43Cyanoamino acid metabolism_Homo sapiens_hsa004601.15933436
44Pancreatic secretion_Homo sapiens_hsa049721.15128192
45Legionellosis_Homo sapiens_hsa051341.12744465
46ABC transporters_Homo sapiens_hsa020101.11121738
47Histidine metabolism_Homo sapiens_hsa003401.08403572
48Insulin resistance_Homo sapiens_hsa049311.04884844
49beta-Alanine metabolism_Homo sapiens_hsa004101.04573095
50Starch and sucrose metabolism_Homo sapiens_hsa005001.03154838
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.01035782
52Antigen processing and presentation_Homo sapiens_hsa046120.99665953
53Retinol metabolism_Homo sapiens_hsa008300.99313704
54Thyroid hormone synthesis_Homo sapiens_hsa049180.98910236
55Tryptophan metabolism_Homo sapiens_hsa003800.98862711
56Linoleic acid metabolism_Homo sapiens_hsa005910.98673272
57Peroxisome_Homo sapiens_hsa041460.98365838
58Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.96052794
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93990121
60Glucagon signaling pathway_Homo sapiens_hsa049220.92540102
61Fructose and mannose metabolism_Homo sapiens_hsa000510.91679949
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.90254987
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89141733
64Cocaine addiction_Homo sapiens_hsa050300.86269768
65Chemical carcinogenesis_Homo sapiens_hsa052040.83630432
66Protein digestion and absorption_Homo sapiens_hsa049740.82030771
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81525146
68Measles_Homo sapiens_hsa051620.81273671
69Asthma_Homo sapiens_hsa053100.80255718
70Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80126411
71Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79242723
72RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78240739
73Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77179174
74Fatty acid metabolism_Homo sapiens_hsa012120.72786945
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.71793776
76Hematopoietic cell lineage_Homo sapiens_hsa046400.70463401
77Tight junction_Homo sapiens_hsa045300.70203964
78Prolactin signaling pathway_Homo sapiens_hsa049170.68811237
79Glutathione metabolism_Homo sapiens_hsa004800.67690282
80Vitamin digestion and absorption_Homo sapiens_hsa049770.67589452
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.67425404
82Collecting duct acid secretion_Homo sapiens_hsa049660.65055352
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63467054
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.62552648
85Arachidonic acid metabolism_Homo sapiens_hsa005900.62378792
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61948043
87Phagosome_Homo sapiens_hsa041450.61871607
88Herpes simplex infection_Homo sapiens_hsa051680.61087890
89Caffeine metabolism_Homo sapiens_hsa002320.60676039
90Amphetamine addiction_Homo sapiens_hsa050310.60612780
91Ribosome_Homo sapiens_hsa030100.60044231
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.56998850
93Phenylalanine metabolism_Homo sapiens_hsa003600.55184891
94Malaria_Homo sapiens_hsa051440.55042259
95Osteoclast differentiation_Homo sapiens_hsa043800.53229920
96Fatty acid degradation_Homo sapiens_hsa000710.51439224
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50554923
98Oxidative phosphorylation_Homo sapiens_hsa001900.50068257
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49670567
100Butanoate metabolism_Homo sapiens_hsa006500.49262808
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.49235382
102Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49234522
103Tuberculosis_Homo sapiens_hsa051520.46003616
104Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45006865
105Leishmaniasis_Homo sapiens_hsa051400.41270771
106Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41248030
107Pertussis_Homo sapiens_hsa051330.41156400
108Taste transduction_Homo sapiens_hsa047420.40781938
109Toll-like receptor signaling pathway_Homo sapiens_hsa046200.40584012
110Circadian rhythm_Homo sapiens_hsa047100.39960456
111Pentose phosphate pathway_Homo sapiens_hsa000300.39900671
112Insulin signaling pathway_Homo sapiens_hsa049100.37273644
113Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.37200218
114TGF-beta signaling pathway_Homo sapiens_hsa043500.37193783
115Glycerolipid metabolism_Homo sapiens_hsa005610.35971113
116Adipocytokine signaling pathway_Homo sapiens_hsa049200.35597701
117Dorso-ventral axis formation_Homo sapiens_hsa043200.35349312
118Toxoplasmosis_Homo sapiens_hsa051450.34771796
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.34313861
120Estrogen signaling pathway_Homo sapiens_hsa049150.34217090
121Ether lipid metabolism_Homo sapiens_hsa005650.34158263
122Inositol phosphate metabolism_Homo sapiens_hsa005620.33568284
123Bile secretion_Homo sapiens_hsa049760.33514470
124Influenza A_Homo sapiens_hsa051640.33378506
125NF-kappa B signaling pathway_Homo sapiens_hsa040640.32857807
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32586071
127Hepatitis C_Homo sapiens_hsa051600.30731871
128Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.28827745
129Endocytosis_Homo sapiens_hsa041440.27116612
130Regulation of autophagy_Homo sapiens_hsa041400.27107610
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.24665380
132TNF signaling pathway_Homo sapiens_hsa046680.24004424
133AMPK signaling pathway_Homo sapiens_hsa041520.23339373
134Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.23303136
135Rheumatoid arthritis_Homo sapiens_hsa053230.22968183
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.22059107
137Renin secretion_Homo sapiens_hsa049240.21518814
138Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21378528
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.21218458
140NOD-like receptor signaling pathway_Homo sapiens_hsa046210.21121948
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.19775918
142Vascular smooth muscle contraction_Homo sapiens_hsa042700.18715928
143Lysine degradation_Homo sapiens_hsa003100.18298934
144Bladder cancer_Homo sapiens_hsa052190.15888638
145Chemokine signaling pathway_Homo sapiens_hsa040620.15433479
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.15373291
147Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.14872408
148Staphylococcus aureus infection_Homo sapiens_hsa051500.14434215
149Apoptosis_Homo sapiens_hsa042100.14297677

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »