MFSD7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to peptidoglycan (GO:0032494)4.98738188
2negative regulation of interleukin-12 production (GO:0032695)4.86386054
3neutrophil activation involved in immune response (GO:0002283)4.50309502
4macrophage activation involved in immune response (GO:0002281)4.24653178
5glycosphingolipid catabolic process (GO:0046479)4.03124565
6positive regulation of gamma-delta T cell activation (GO:0046645)3.90816129
7amino sugar catabolic process (GO:0046348)3.89481818
8immunoglobulin mediated immune response (GO:0016064)3.87957100
9modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.87090258
10positive regulation by organism of defense response of other organism involved in symbiotic interact3.87090258
11modulation by symbiont of host immune response (GO:0052553)3.87090258
12positive regulation by symbiont of host defense response (GO:0052509)3.87090258
13modulation by symbiont of host defense response (GO:0052031)3.87090258
14modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.87090258
15oligosaccharide catabolic process (GO:0009313)3.69869079
16cellular response to thyroid hormone stimulus (GO:0097067)3.64607220
17negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.63229039
18negative regulation of cell killing (GO:0031342)3.63229039
19lipopolysaccharide-mediated signaling pathway (GO:0031663)3.62424161
20glycolipid catabolic process (GO:0019377)3.61516592
21detection of molecule of bacterial origin (GO:0032490)3.57380369
22regulation of mast cell degranulation (GO:0043304)3.52631357
23detection of other organism (GO:0098543)3.52375207
24regulation of mononuclear cell migration (GO:0071675)3.41594306
25negative regulation of erythrocyte differentiation (GO:0045647)3.39285795
26cellular extravasation (GO:0045123)3.35903850
27detection of bacterium (GO:0016045)3.32488463
28detection of external biotic stimulus (GO:0098581)3.31868614
29T-helper 1 type immune response (GO:0042088)3.27301036
30ceramide catabolic process (GO:0046514)3.24518954
31regulation of leukocyte degranulation (GO:0043300)3.21654696
32granulocyte activation (GO:0036230)3.20662196
33regulation of mast cell activation involved in immune response (GO:0033006)3.18797757
34germinal center formation (GO:0002467)3.16304047
35myeloid dendritic cell differentiation (GO:0043011)3.15577305
36regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13805390
37positive regulation of mast cell activation (GO:0033005)3.12558136
38positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.12462763
39response to muramyl dipeptide (GO:0032495)3.11905161
40regulation of T-helper 2 cell differentiation (GO:0045628)3.10143159
41regulation of vitamin D biosynthetic process (GO:0060556)3.09034885
42NIK/NF-kappaB signaling (GO:0038061)3.09020071
43regulation of interferon-beta biosynthetic process (GO:0045357)3.08272205
44positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.07194225
45macrophage activation (GO:0042116)3.06875964
46negative regulation of cytokine production involved in immune response (GO:0002719)3.06275535
47positive regulation of mast cell degranulation (GO:0043306)3.05179391
48positive regulation of mast cell activation involved in immune response (GO:0033008)3.05179391
49regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.04757447
50positive regulation of antigen processing and presentation (GO:0002579)3.01915714
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01284498
52myeloid cell activation involved in immune response (GO:0002275)2.99487564
53interferon-gamma-mediated signaling pathway (GO:0060333)2.98486717
54mannose metabolic process (GO:0006013)2.97915371
55negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97022532
56regulation of gamma-delta T cell activation (GO:0046643)2.96431404
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.95982499
58response to thyroid hormone (GO:0097066)2.95977559
59detection of biotic stimulus (GO:0009595)2.92432809
60regulation of mast cell activation (GO:0033003)2.92334335
61positive regulation of leukocyte degranulation (GO:0043302)2.92312517
62regulation of antigen processing and presentation (GO:0002577)2.92006498
63positive regulation of cellular amide metabolic process (GO:0034250)2.88325288
64cellular response to type I interferon (GO:0071357)2.87787612
65type I interferon signaling pathway (GO:0060337)2.87787612
66response to type I interferon (GO:0034340)2.86824800
67neutrophil activation (GO:0042119)2.86487818
68barbed-end actin filament capping (GO:0051016)2.86035033
69regulation of dendritic cell antigen processing and presentation (GO:0002604)2.85889064
70myeloid dendritic cell activation (GO:0001773)2.84440580
71respiratory burst (GO:0045730)2.83953267
72regulation of cholesterol storage (GO:0010885)2.81829298
73defense response to protozoan (GO:0042832)2.81767720
74response to protozoan (GO:0001562)2.81270674
75membrane lipid catabolic process (GO:0046466)2.80444302
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.80230131
77antigen processing and presentation of endogenous antigen (GO:0019883)2.79535215
78monocyte chemotaxis (GO:0002548)2.79397758
79N-acetylneuraminate metabolic process (GO:0006054)2.78514204
80positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.75959796
81positive regulation of type 2 immune response (GO:0002830)2.75677964
82regulation of interferon-alpha production (GO:0032647)2.75479477
83positive regulation of chemokine biosynthetic process (GO:0045080)2.74116641
84B cell mediated immunity (GO:0019724)2.72665516
85sphingolipid catabolic process (GO:0030149)2.72655001
86negative regulation of nitric oxide biosynthetic process (GO:0045019)2.69494436
87adhesion of symbiont to host cell (GO:0044650)2.69318582
88virion attachment to host cell (GO:0019062)2.69318582
89regulation of podosome assembly (GO:0071801)2.69244810
90positive regulation of monocyte chemotaxis (GO:0090026)2.66149699
91neutrophil chemotaxis (GO:0030593)2.65232133
92antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61323261
93pinocytosis (GO:0006907)2.60578206
94regulation of membrane protein ectodomain proteolysis (GO:0051043)2.60351280
95negative regulation of myeloid cell apoptotic process (GO:0033033)2.59568402
96regulation of macrophage chemotaxis (GO:0010758)2.59532839
97response to host immune response (GO:0052572)2.59385296
98response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.59385296
99regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.58950945
100positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.58830348

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.42686334
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.88128197
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.84209202
4* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human3.51645220
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.02995449
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.98789087
7NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70310458
8VDR_21846776_ChIP-Seq_THP-1_Human2.69079482
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.55008186
10RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.51160626
11VDR_24763502_ChIP-Seq_THP-1_Human2.40176276
12LXR_22292898_ChIP-Seq_THP-1_Human2.30803245
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.24079507
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.23362856
15KDM2B_26808549_Chip-Seq_SUP-B15_Human2.15109276
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.13428143
17RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12634979
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.11385581
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.05246992
20STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.05034600
21SPI1_23127762_ChIP-Seq_K562_Human2.04545846
22RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03173624
23BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97382972
24STAT4_19710469_ChIP-ChIP_TH1__Mouse1.87517887
25RUNX1_22412390_ChIP-Seq_EML_Mouse1.81059228
26SPI1_23547873_ChIP-Seq_NB4_Human1.76594055
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.73589119
28E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73524819
29TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.72642454
30KDM2B_26808549_Chip-Seq_DND41_Human1.70756746
31SCL_19346495_ChIP-Seq_HPC-7_Human1.70052253
32IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.69652086
33SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.67316351
34TCF7_22412390_ChIP-Seq_EML_Mouse1.67206286
35VDR_24787735_ChIP-Seq_THP-1_Human1.66195726
36MAF_26560356_Chip-Seq_TH1_Human1.66106106
37KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65582419
38ESR2_21235772_ChIP-Seq_MCF-7_Human1.64490477
39MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64011870
40CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.63266571
41VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62994241
42STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.58372522
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55704124
44EGR1_19374776_ChIP-ChIP_THP-1_Human1.50028519
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.46585956
46* RACK7_27058665_Chip-Seq_MCF-7_Human1.45244774
47PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42764779
48CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39757680
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.39227080
50UTX_26944678_Chip-Seq_JUKART_Human1.38398636
51MYC_22102868_ChIP-Seq_BL_Human1.38103836
52GATA1_19941827_ChIP-Seq_MEL_Mouse1.37052904
53PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.36659796
54LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.36470398
55MAF_26560356_Chip-Seq_TH2_Human1.35259359
56GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.32810700
57PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32069008
58BCOR_27268052_Chip-Seq_Bcells_Human1.28370427
59* BCL6_27268052_Chip-Seq_Bcells_Human1.28231057
60RUNX_20019798_ChIP-Seq_JUKART_Human1.25210490
61SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23783353
62CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.22888440
63KDM2B_26808549_Chip-Seq_K562_Human1.22275858
64TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21996164
65GATA1_19941826_ChIP-Seq_K562_Human1.21359779
66PU_27001747_Chip-Seq_BMDM_Mouse1.20721305
67IKZF1_21737484_ChIP-ChIP_HCT116_Human1.20703300
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19966476
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18749732
70CTCF_27219007_Chip-Seq_ERYTHROID_Human1.18408994
71GATA2_21666600_ChIP-Seq_HMVEC_Human1.16043651
72ESR1_21235772_ChIP-Seq_MCF-7_Human1.14650922
73ELF1_20517297_ChIP-Seq_JURKAT_Human1.14188544
74P68_20966046_ChIP-Seq_HELA_Human1.13825092
75FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12694751
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.12074667
77PPARA_22158963_ChIP-Seq_LIVER_Mouse1.11668496
78RXR_22158963_ChIP-Seq_LIVER_Mouse1.11511029
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.10876250
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.10528916
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08980641
82SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05963145
83TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.05855558
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.05733861
85SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04821028
86STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.04592533
87FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.03883871
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01511922
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01315564
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00815355
91PU.1_20513432_ChIP-Seq_Bcells_Mouse1.00565011
92GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00051609
93TP63_17297297_ChIP-ChIP_HaCaT_Human0.99375780
94KDM2B_26808549_Chip-Seq_JURKAT_Human0.98564345
95KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.96669388
96GATA1_22025678_ChIP-Seq_K562_Human0.95857392
97STAT1_20625510_ChIP-Seq_HELA_Human0.95541085
98MYB_26560356_Chip-Seq_TH2_Human0.95480650
99CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93172390
100NCOR1_26117541_ChIP-Seq_K562_Human0.93003424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.17300387
2MP0003303_peritoneal_inflammation4.12515373
3MP0003436_decreased_susceptibility_to3.43561585
4MP0003724_increased_susceptibility_to3.37453163
5MP0006082_CNS_inflammation3.20032983
6MP0009840_abnormal_foam_cell2.99260254
7MP0003172_abnormal_lysosome_physiology2.88298463
8MP0002148_abnormal_hypersensitivity_rea2.85549084
9MP0002419_abnormal_innate_immunity2.75634315
10MP0001835_abnormal_antigen_presentation2.68558854
11MP0009785_altered_susceptibility_to2.66500926
12MP0004510_myositis2.52923704
13MP0003191_abnormal_cellular_cholesterol2.45542086
14MP0005671_abnormal_response_to2.44035274
15MP0005387_immune_system_phenotype2.43924460
16MP0001790_abnormal_immune_system2.43924460
17MP0005025_abnormal_response_to2.39809001
18MP0005000_abnormal_immune_tolerance2.35165504
19MP0003300_gastrointestinal_ulcer2.32814348
20MP0000343_altered_response_to2.22189013
21MP0001533_abnormal_skeleton_physiology2.13310768
22MP0003075_altered_response_to2.04352709
23MP0002452_abnormal_antigen_presenting2.02285160
24MP0000604_amyloidosis2.02067183
25MP0009278_abnormal_bone_marrow1.93905773
26MP0002723_abnormal_immune_serum1.93353338
27MP0002998_abnormal_bone_remodeling1.89990223
28MP0000685_abnormal_immune_system1.89491065
29MP0005451_abnormal_body_composition1.87701595
30MP0001800_abnormal_humoral_immune1.85149039
31MP0002139_abnormal_hepatobiliary_system1.75979867
32MP0002254_reproductive_system_inflammat1.75624526
33MP0009764_decreased_sensitivity_to1.74675701
34MP0001819_abnormal_immune_cell1.70888728
35MP0002420_abnormal_adaptive_immunity1.70362106
36MP0004947_skin_inflammation1.68438544
37MP0003806_abnormal_nucleotide_metabolis1.68097687
38MP0001845_abnormal_inflammatory_respons1.60785328
39MP0002405_respiratory_system_inflammati1.57107201
40MP0001853_heart_inflammation1.53615420
41MP0008469_abnormal_protein_level1.51220775
42MP0010155_abnormal_intestine_physiology1.49320100
43MP0005464_abnormal_platelet_physiology1.48442756
44MP0003453_abnormal_keratinocyte_physiol1.47829142
45MP0003690_abnormal_glial_cell1.46655073
46MP0008004_abnormal_stomach_pH1.45275548
47MP0005310_abnormal_salivary_gland1.42498294
48MP0000858_altered_metastatic_potential1.41504825
49MP0003828_pulmonary_edema1.41366504
50MP0005397_hematopoietic_system_phenotyp1.37086536
51MP0001545_abnormal_hematopoietic_system1.37086536
52MP0005167_abnormal_blood-brain_barrier1.36539533
53MP0003448_altered_tumor_morphology1.35987809
54MP0008260_abnormal_autophagy1.34928390
55MP0003279_aneurysm1.27032272
56MP0005166_decreased_susceptibility_to1.25311916
57MP0009333_abnormal_splenocyte_physiolog1.23315713
58MP0000716_abnormal_immune_system1.15659638
59MP0003329_amyloid_beta_deposits1.08810479
60MP0003183_abnormal_peptide_metabolism1.06995094
61MP0002933_joint_inflammation1.06821252
62MP0005390_skeleton_phenotype1.05705966
63MP0003705_abnormal_hypodermis_morpholog1.03262109
64MP0005164_abnormal_response_to1.02490311
65MP0004883_abnormal_blood_vessel0.95838838
66MP0002138_abnormal_hepatobiliary_system0.94077022
67MP0001849_ear_inflammation0.93206960
68MP0006054_spinal_hemorrhage0.92538014
69MP0003195_calcinosis0.90783119
70MP0002398_abnormal_bone_marrow0.90530017
71MP0003091_abnormal_cell_migration0.89896259
72MP0003656_abnormal_erythrocyte_physiolo0.89515344
73MP0000920_abnormal_myelination0.88006507
74MP0005165_increased_susceptibility_to0.87923611
75MP0003795_abnormal_bone_structure0.87874689
76MP0002429_abnormal_blood_cell0.87508643
77MP0005023_abnormal_wound_healing0.86248827
78MP0005365_abnormal_bile_salt0.85420958
79MP0001542_abnormal_bone_strength0.84923482
80MP0000249_abnormal_blood_vessel0.81742754
81MP0000689_abnormal_spleen_morphology0.81292913
82MP0002277_abnormal_respiratory_mucosa0.80026460
83MP0001851_eye_inflammation0.79733870
84MP0001958_emphysema0.77924417
85MP0000465_gastrointestinal_hemorrhage0.77603401
86MP0001663_abnormal_digestive_system0.77020121
87MP0009763_increased_sensitivity_to0.77002387
88MP0002722_abnormal_immune_system0.73037494
89MP0005076_abnormal_cell_differentiation0.72511207
90MP0000767_abnormal_smooth_muscle0.72337034
91MP0005595_abnormal_vascular_smooth0.69697232
92MP0000371_diluted_coat_color0.67080928
93MP0002332_abnormal_exercise_endurance0.67002439
94MP0008874_decreased_physiological_sensi0.65998774
95MP0005319_abnormal_enzyme/_coenzyme0.63119973
96MP0005647_abnormal_sex_gland0.62819170
97MP0002877_abnormal_melanocyte_morpholog0.62292848
98MP0001873_stomach_inflammation0.61458268
99MP0003763_abnormal_thymus_physiology0.60376552
100MP0005257_abnormal_intraocular_pressure0.58493068

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.95737557
2Abnormality of liposaccharide metabolism (HP:0010968)6.95737557
3Abnormality of glycosphingolipid metabolism (HP:0004343)6.95737557
4Abnormality of macrophages (HP:0004311)5.00855701
5Increased cerebral lipofuscin (HP:0011813)4.85751867
6Eczematoid dermatitis (HP:0000976)4.80446294
7Vacuolated lymphocytes (HP:0001922)4.73397221
8Systemic lupus erythematosus (HP:0002725)4.63871674
9Dysostosis multiplex (HP:0000943)4.55400895
10Recurrent bacterial skin infections (HP:0005406)4.26863003
11Recurrent abscess formation (HP:0002722)4.23532984
12Loss of speech (HP:0002371)4.13979064
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.99092953
14Myositis (HP:0100614)3.89788287
15Orchitis (HP:0100796)3.88610893
16Recurrent gram-negative bacterial infections (HP:0005420)3.78454856
17Abnormality of polysaccharide metabolism (HP:0011012)3.73817356
18Abnormality of glycosaminoglycan metabolism (HP:0004371)3.73817356
19Abnormality of mucopolysaccharide metabolism (HP:0011020)3.73817356
20Optic neuritis (HP:0100653)3.68179877
21Retrobulbar optic neuritis (HP:0100654)3.68179877
22Urinary glycosaminoglycan excretion (HP:0003541)3.53254389
23Mucopolysacchariduria (HP:0008155)3.53254389
24Disinhibition (HP:0000734)3.47610604
25Axonal loss (HP:0003447)3.44223024
26Nuclear cataract (HP:0100018)3.33778285
27Mediastinal lymphadenopathy (HP:0100721)3.26474982
28Neurofibrillary tangles (HP:0002185)2.95332898
29Mutism (HP:0002300)2.94279979
30Glomerulonephritis (HP:0000099)2.90144669
31Stomatitis (HP:0010280)2.78558864
32Autoimmune thrombocytopenia (HP:0001973)2.74771669
33Chronic obstructive pulmonary disease (HP:0006510)2.73863726
34Obstructive lung disease (HP:0006536)2.73863726
35Purpura (HP:0000979)2.73153771
36Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72971076
37Myocardial infarction (HP:0001658)2.70162560
38Gingivitis (HP:0000230)2.68762340
39Amyloidosis (HP:0011034)2.65733439
40Hepatosplenomegaly (HP:0001433)2.65612490
41Recurrent skin infections (HP:0001581)2.64225322
42Pulmonary infiltrates (HP:0002113)2.52368531
43Keratoconjunctivitis sicca (HP:0001097)2.52191980
44Spontaneous hematomas (HP:0007420)2.50834598
45Hemoptysis (HP:0002105)2.49147958
46Increased serum ferritin (HP:0003281)2.47919222
47Recurrent fungal infections (HP:0002841)2.44290794
48Thin bony cortex (HP:0002753)2.38322310
49Progressive neurologic deterioration (HP:0002344)2.35295152
50Neuronal loss in central nervous system (HP:0002529)2.34529902
51Hematochezia (HP:0002573)2.34175988
52Asymmetric septal hypertrophy (HP:0001670)2.34142462
53Complement deficiency (HP:0004431)2.32284689
54Elevated erythrocyte sedimentation rate (HP:0003565)2.31235272
55Keratoconjunctivitis (HP:0001096)2.29076133
56Upper motor neuron abnormality (HP:0002127)2.23413826
57Interstitial pulmonary disease (HP:0006530)2.22651831
58Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.22642191
59Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22499075
60Malnutrition (HP:0004395)2.20360803
61Meningitis (HP:0001287)2.20132111
62Diminished motivation (HP:0000745)2.18647195
63Cerebral inclusion bodies (HP:0100314)2.18312152
64Apathy (HP:0000741)2.17015822
65Petechiae (HP:0000967)2.15976769
66Vasculitis (HP:0002633)2.15892629
67Pathologic fracture (HP:0002756)2.13518837
68Abnormality of complement system (HP:0005339)2.11448944
69J-shaped sella turcica (HP:0002680)2.08466111
70Joint stiffness (HP:0001387)2.05932658
71Premature loss of primary teeth (HP:0006323)2.05232777
72Increased IgE level (HP:0003212)2.02946875
73Cellulitis (HP:0100658)2.02065807
74Gastrointestinal infarctions (HP:0005244)2.01546880
75Abnormality of the nasal mucosa (HP:0000433)2.01422920
76Recurrent cutaneous fungal infections (HP:0011370)1.98322292
77Chronic mucocutaneous candidiasis (HP:0002728)1.98322292
78Metaphyseal irregularity (HP:0003025)1.98305481
79Abnormality of iron homeostasis (HP:0011031)1.96843653
80Polyneuropathy (HP:0001271)1.96385663
81Dementia (HP:0000726)1.95481858
82Bone pain (HP:0002653)1.94917302
83Urticaria (HP:0001025)1.93635454
84Vertebral compression fractures (HP:0002953)1.85457602
85Cervical subluxation (HP:0003308)1.85434834
86Basal ganglia calcification (HP:0002135)1.85360389
87Restrictive lung disease (HP:0002091)1.83789782
88Encephalitis (HP:0002383)1.83040332
89Personality changes (HP:0000751)1.81906899
90Thoracic kyphosis (HP:0002942)1.81330591
91Agnosia (HP:0010524)1.81195840
92Prolonged neonatal jaundice (HP:0006579)1.81136955
93Pulmonary embolism (HP:0002204)1.80945075
94Abnormality of the periventricular white matter (HP:0002518)1.77089751
95Nephritis (HP:0000123)1.76178317
96Colitis (HP:0002583)1.76147571
97Arterial thrombosis (HP:0004420)1.75911527
98Acne (HP:0001061)1.75213636
99Gangrene (HP:0100758)1.74230355
100Global brain atrophy (HP:0002283)1.74057393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK3.06603774
2RIPK42.97409997
3IRAK32.89771691
4ERN12.75253649
5MAP3K142.51062325
6NME22.48186223
7MAP4K12.47900415
8TBK12.37744249
9MAP2K32.29153129
10CSK2.27818029
11TYK22.27238332
12TGFBR22.22865553
13IRAK42.14746638
14MAP3K112.11032722
15GRK71.98487897
16MAP3K31.95298656
17TAOK11.95207009
18ZAP701.95032260
19PRPF4B1.94596941
20DDR21.83791788
21TAOK21.82406660
22RIPK11.79272646
23MAP3K131.79147798
24FGR1.77889048
25MATK1.77174311
26CDC42BPA1.64488893
27SIK11.60620511
28TRIB31.57457766
29TNK21.46432511
30IKBKB1.45858764
31JAK31.45610041
32IKBKE1.41808458
33TXK1.38584270
34FES1.32913598
35MAP3K11.25168702
36EPHB11.23480848
37CSF1R1.13606738
38MAPK151.09908379
39SYK1.08455935
40MOS1.05919307
41TESK11.04316065
42HCK1.03570920
43ABL21.03296086
44KIT1.03109161
45LYN1.02581743
46TESK21.01539006
47MAP2K61.01331814
48JAK10.97716620
49MARK20.96457040
50PRKD20.96218361
51IRAK20.93731907
52PIM20.92461286
53MAP3K60.92398071
54BTK0.91985786
55CHUK0.87939597
56JAK20.87732414
57SIK30.86559156
58KDR0.84163279
59LCK0.81168865
60CAMK1D0.78766831
61PDPK10.77528957
62MAPK70.76960949
63TTN0.76664486
64RPS6KA20.76289021
65GRK60.75989317
66PAK40.75644075
67RPS6KC10.75101181
68RPS6KL10.75101181
69MAPK120.71015892
70NEK90.67559882
71MARK30.67518535
72IRAK10.64301250
73RPS6KA60.61610733
74EPHA30.61499303
75PTK60.60829563
76BMX0.60446019
77CAMKK20.59226015
78ARAF0.58812397
79PDK10.56924802
80ADRBK20.55774210
81PRKG20.54714631
82MAP3K50.53967107
83ACVR1B0.53191965
84KSR20.49784665
85DAPK20.49403979
86HIPK20.47165921
87MAPK40.45130369
88FGFR40.44182721
89PDGFRB0.43206492
90PDGFRA0.42433934
91BMPR20.42012779
92ITK0.39667072
93SIK20.39244934
94ICK0.36681267
95FYN0.35619415
96MAPKAPK20.35180447
97STK100.32955444
98ABL10.32534126
99PRKD10.30870275
100MAPKAPK30.30843264

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.90384826
2Staphylococcus aureus infection_Homo sapiens_hsa051503.06116933
3Lysosome_Homo sapiens_hsa041423.03125774
4Osteoclast differentiation_Homo sapiens_hsa043802.80830353
5Leishmaniasis_Homo sapiens_hsa051402.62085346
6Glycosaminoglycan degradation_Homo sapiens_hsa005312.61911860
7Rheumatoid arthritis_Homo sapiens_hsa053232.40410951
8Toll-like receptor signaling pathway_Homo sapiens_hsa046202.31026793
9Allograft rejection_Homo sapiens_hsa053302.18201795
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16725161
11Tuberculosis_Homo sapiens_hsa051522.13626329
12Malaria_Homo sapiens_hsa051442.01723814
13Graft-versus-host disease_Homo sapiens_hsa053321.99544353
14Asthma_Homo sapiens_hsa053101.97361519
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.89278167
16Autoimmune thyroid disease_Homo sapiens_hsa053201.85619688
17Pertussis_Homo sapiens_hsa051331.84143147
18NF-kappa B signaling pathway_Homo sapiens_hsa040641.77803062
19Phagosome_Homo sapiens_hsa041451.69968719
20TNF signaling pathway_Homo sapiens_hsa046681.68629846
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.68549285
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.66468595
23Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62891153
24Antigen processing and presentation_Homo sapiens_hsa046121.55248692
25Legionellosis_Homo sapiens_hsa051341.54938488
26Toxoplasmosis_Homo sapiens_hsa051451.53856716
27Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.47654347
28Type I diabetes mellitus_Homo sapiens_hsa049401.43021340
29Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42928157
30B cell receptor signaling pathway_Homo sapiens_hsa046621.42373347
31Salmonella infection_Homo sapiens_hsa051321.41407170
32Hematopoietic cell lineage_Homo sapiens_hsa046401.40634547
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.38724684
34RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37511249
35Influenza A_Homo sapiens_hsa051641.32811247
36Collecting duct acid secretion_Homo sapiens_hsa049661.25882071
37Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20464373
38Chemokine signaling pathway_Homo sapiens_hsa040621.14818934
39Viral myocarditis_Homo sapiens_hsa054161.14405467
40Acute myeloid leukemia_Homo sapiens_hsa052211.13278750
41African trypanosomiasis_Homo sapiens_hsa051431.10854315
42Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05722156
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03677240
44Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03308737
45Hepatitis C_Homo sapiens_hsa051601.00566146
46Prion diseases_Homo sapiens_hsa050201.00251385
47Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00132472
48Amoebiasis_Homo sapiens_hsa051460.98019693
49Measles_Homo sapiens_hsa051620.96699358
50Herpes simplex infection_Homo sapiens_hsa051680.93805975
51Complement and coagulation cascades_Homo sapiens_hsa046100.91287383
52Shigellosis_Homo sapiens_hsa051310.89525569
53Notch signaling pathway_Homo sapiens_hsa043300.88728466
54Jak-STAT signaling pathway_Homo sapiens_hsa046300.87964323
55VEGF signaling pathway_Homo sapiens_hsa043700.84843523
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.83281838
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.83203630
58AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.82896877
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82294571
60Bladder cancer_Homo sapiens_hsa052190.79180283
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.77794313
62Apoptosis_Homo sapiens_hsa042100.77522391
63Hepatitis B_Homo sapiens_hsa051610.77419744
64Sphingolipid metabolism_Homo sapiens_hsa006000.76879597
65T cell receptor signaling pathway_Homo sapiens_hsa046600.72579478
66Galactose metabolism_Homo sapiens_hsa000520.69482200
67Primary immunodeficiency_Homo sapiens_hsa053400.66784310
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.62325386
69Prolactin signaling pathway_Homo sapiens_hsa049170.61174460
70Vibrio cholerae infection_Homo sapiens_hsa051100.60666321
71Mineral absorption_Homo sapiens_hsa049780.60193452
72PPAR signaling pathway_Homo sapiens_hsa033200.59691014
73Endocytosis_Homo sapiens_hsa041440.57205951
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.56054706
75Platelet activation_Homo sapiens_hsa046110.54693324
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.54279867
77Fructose and mannose metabolism_Homo sapiens_hsa000510.49832700
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.48785868
79GnRH signaling pathway_Homo sapiens_hsa049120.46783767
80Epstein-Barr virus infection_Homo sapiens_hsa051690.44497019
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44487075
82Chronic myeloid leukemia_Homo sapiens_hsa052200.41153422
83Insulin resistance_Homo sapiens_hsa049310.39550700
84Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39519158
85HIF-1 signaling pathway_Homo sapiens_hsa040660.33687999
86HTLV-I infection_Homo sapiens_hsa051660.32228366
87Renal cell carcinoma_Homo sapiens_hsa052110.32208739
88Pancreatic cancer_Homo sapiens_hsa052120.31899367
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28955271
90Type II diabetes mellitus_Homo sapiens_hsa049300.27863140
91Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27064550
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.24501365
93MAPK signaling pathway_Homo sapiens_hsa040100.24337903
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.23300868
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23256224
96Dorso-ventral axis formation_Homo sapiens_hsa043200.22450250
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.22221221
98Renin-angiotensin system_Homo sapiens_hsa046140.22018427
99Carbohydrate digestion and absorption_Homo sapiens_hsa049730.21716824
100Estrogen signaling pathway_Homo sapiens_hsa049150.21346091

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