MFSD9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein prenylation (GO:0018342)8.11035340
2prenylation (GO:0097354)8.11035340
3L-fucose catabolic process (GO:0042355)7.25133235
4fucose catabolic process (GO:0019317)7.25133235
5L-fucose metabolic process (GO:0042354)7.25133235
6negative regulation of Ras GTPase activity (GO:0034261)6.29207353
7positive regulation of mitotic sister chromatid separation (GO:1901970)6.04728615
8positive regulation of mitotic metaphase/anaphase transition (GO:0045842)6.04728615
9positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)6.04728615
10negative regulation of T cell receptor signaling pathway (GO:0050860)5.30897422
11oxidative demethylation (GO:0070989)4.76085297
12eosinophil chemotaxis (GO:0048245)4.71715697
13protein import into peroxisome matrix (GO:0016558)4.71555515
14regulation of sister chromatid cohesion (GO:0007063)4.42860048
15autophagic vacuole fusion (GO:0000046)4.42359108
16peptidyl-lysine dimethylation (GO:0018027)4.38280082
17cysteine metabolic process (GO:0006534)4.37927018
18negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)4.37173215
19pantothenate metabolic process (GO:0015939)4.30342159
20lysine metabolic process (GO:0006553)4.29836523
21lysine catabolic process (GO:0006554)4.29836523
22eosinophil migration (GO:0072677)4.28748830
23coenzyme A biosynthetic process (GO:0015937)4.26914880
24short-chain fatty acid metabolic process (GO:0046459)4.26030344
25organ growth (GO:0035265)4.21898309
26fucosylation (GO:0036065)4.18964197
27histone H3-K9 methylation (GO:0051567)4.18948784
28seminiferous tubule development (GO:0072520)4.13667189
29ribosomal small subunit assembly (GO:0000028)4.11698853
30preassembly of GPI anchor in ER membrane (GO:0016254)4.08023315
31sulfur amino acid catabolic process (GO:0000098)4.05633832
32L-serine transport (GO:0015825)3.92927282
33response to pheromone (GO:0019236)3.86241586
34organelle membrane fusion (GO:0090174)3.83167455
35drug transmembrane transport (GO:0006855)3.82438081
36fucose metabolic process (GO:0006004)3.80178318
37vesicle fusion (GO:0006906)3.79883184
38cellular modified amino acid catabolic process (GO:0042219)3.79008083
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.75216827
40ethanol oxidation (GO:0006069)3.65362923
41branch elongation of an epithelium (GO:0060602)3.62504026
42detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.60790776
43transepithelial transport (GO:0070633)3.59596840
44negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.58775118
45drug transport (GO:0015893)3.58402189
46mitochondrial RNA metabolic process (GO:0000959)3.55783759
47negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.54057218
48drug catabolic process (GO:0042737)3.52035144
49behavioral response to nicotine (GO:0035095)3.48776683
50urate metabolic process (GO:0046415)3.47287655
51modified amino acid transport (GO:0072337)3.45579369
52negative regulation of sterol transport (GO:0032372)3.44889954
53negative regulation of cholesterol transport (GO:0032375)3.44889954
54iron-sulfur cluster assembly (GO:0016226)3.43186484
55metallo-sulfur cluster assembly (GO:0031163)3.43186484
56histone H3-K9 modification (GO:0061647)3.41903585
57regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.41581208
58amino-acid betaine metabolic process (GO:0006577)3.40975813
59regulation of cholesterol esterification (GO:0010872)3.37904591
60tRNA modification (GO:0006400)3.35620487
61homocysteine metabolic process (GO:0050667)3.34352382
62sodium-independent organic anion transport (GO:0043252)3.33827689
63aspartate family amino acid catabolic process (GO:0009068)3.33593595
64nucleobase catabolic process (GO:0046113)3.32018747
65regulation of T cell receptor signaling pathway (GO:0050856)3.29392167
66DNA demethylation (GO:0080111)3.29377946
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.28970898
68L-phenylalanine catabolic process (GO:0006559)3.28970898
69alanine transport (GO:0032328)3.27653922
70protein targeting to peroxisome (GO:0006625)3.25934467
71establishment of protein localization to peroxisome (GO:0072663)3.25934467
72protein localization to peroxisome (GO:0072662)3.25934467
73reverse cholesterol transport (GO:0043691)3.25576927
74alpha-linolenic acid metabolic process (GO:0036109)3.24151727
75tryptophan catabolic process (GO:0006569)3.23612696
76indole-containing compound catabolic process (GO:0042436)3.23612696
77indolalkylamine catabolic process (GO:0046218)3.23612696
78serine transport (GO:0032329)3.23034014
79cellular glucuronidation (GO:0052695)3.22277653
80positive regulation of chromosome segregation (GO:0051984)3.21536649
81acrosome assembly (GO:0001675)3.21399579
82regulation of mononuclear cell migration (GO:0071675)3.20181684
83sodium ion export (GO:0071436)3.17177170
84detection of chemical stimulus involved in sensory perception of taste (GO:0050912)3.16085942
85imidazole-containing compound metabolic process (GO:0052803)3.12991456
86protein-lipid complex assembly (GO:0065005)3.12974851
87uronic acid metabolic process (GO:0006063)3.12765418
88glucuronate metabolic process (GO:0019585)3.12765418
89acetyl-CoA metabolic process (GO:0006084)3.10798909
90ethanol metabolic process (GO:0006067)3.10384976
91purine nucleoside bisphosphate biosynthetic process (GO:0034033)3.10311871
92ribonucleoside bisphosphate biosynthetic process (GO:0034030)3.10311871
93nucleoside bisphosphate biosynthetic process (GO:0033866)3.10311871
94coenzyme A metabolic process (GO:0015936)3.09351383
95cellular ketone body metabolic process (GO:0046950)3.08410733
96plasma lipoprotein particle assembly (GO:0034377)3.08123877
97regulation of bile acid biosynthetic process (GO:0070857)3.06593311
98phospholipid efflux (GO:0033700)3.06291873
99intestinal absorption (GO:0050892)3.05736533
100glyoxylate metabolic process (GO:0046487)3.05417444
101GPI anchor metabolic process (GO:0006505)3.05107640
102L-phenylalanine metabolic process (GO:0006558)3.03870577
103erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.03870577
104high-density lipoprotein particle remodeling (GO:0034375)3.03333701
105very-low-density lipoprotein particle assembly (GO:0034379)2.98467850
106carnitine metabolic process (GO:0009437)2.96392656
107positive regulation of catecholamine secretion (GO:0033605)2.95183792
108angiotensin maturation (GO:0002003)2.94676049
109proline transport (GO:0015824)2.94287165
110early endosome to late endosome transport (GO:0045022)2.94286950
111pyrimidine nucleobase catabolic process (GO:0006208)2.94151731
112peptidyl-lysine trimethylation (GO:0018023)2.93912293
113DNA integration (GO:0015074)2.92581300
114GPI anchor biosynthetic process (GO:0006506)2.91867345
115indolalkylamine metabolic process (GO:0006586)2.91053212
116peroxisomal transport (GO:0043574)2.89716635
117cholesterol efflux (GO:0033344)2.87517460
118intestinal cholesterol absorption (GO:0030299)2.86476095
119cellular potassium ion homeostasis (GO:0030007)2.86356915
120low-density lipoprotein particle remodeling (GO:0034374)2.84594171
121positive regulation of calcium ion import (GO:0090280)2.84525436
122positive regulation of amino acid transport (GO:0051957)2.83909581
123plasma lipoprotein particle remodeling (GO:0034369)2.82535831
124protein-lipid complex remodeling (GO:0034368)2.82535831
125macromolecular complex remodeling (GO:0034367)2.82535831
126aromatic amino acid family catabolic process (GO:0009074)2.81066523
127renal absorption (GO:0070293)2.79454353
128membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78701729
129regulation of beta-amyloid formation (GO:1902003)2.78329450
130regulation of cholesterol biosynthetic process (GO:0045540)2.77927753
131fructose metabolic process (GO:0006000)2.77619139
132beta-amyloid metabolic process (GO:0050435)2.77413002
133adhesion of symbiont to host cell (GO:0044650)2.77289664
134virion attachment to host cell (GO:0019062)2.77289664
135organic cation transport (GO:0015695)2.75507011
136glutamate metabolic process (GO:0006536)2.75445898
137acyl-CoA biosynthetic process (GO:0071616)2.74913233
138thioester biosynthetic process (GO:0035384)2.74913233
139RNA methylation (GO:0001510)2.74547423
140exogenous drug catabolic process (GO:0042738)2.74536228
141regulation of triglyceride catabolic process (GO:0010896)2.74062348
142regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.73340492
143polyol transport (GO:0015791)2.71740370
144RNA modification (GO:0009451)2.71432007
145fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.70525488
146aminoglycoside antibiotic metabolic process (GO:0030647)2.69998695
147tryptophan metabolic process (GO:0006568)2.69947915
148non-recombinational repair (GO:0000726)2.69460123
149double-strand break repair via nonhomologous end joining (GO:0006303)2.69460123
150calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.69388693
151vitamin transmembrane transport (GO:0035461)2.67881869
152protein targeting to lysosome (GO:0006622)2.66561711
153establishment of protein localization to vacuole (GO:0072666)2.66561711
154protein targeting to vacuole (GO:0006623)2.66561711
155DNA dealkylation (GO:0035510)2.65592226
156flavonoid metabolic process (GO:0009812)2.65290503
157protein-lipid complex subunit organization (GO:0071825)2.64972494
158ketone body metabolic process (GO:1902224)2.63842384
159nucleoside bisphosphate metabolic process (GO:0033865)2.63808692
160purine nucleoside bisphosphate metabolic process (GO:0034032)2.63808692
161ribonucleoside bisphosphate metabolic process (GO:0033875)2.63808692
162glutathione biosynthetic process (GO:0006750)2.61823885
163lipid oxidation (GO:0034440)2.61067204
164serine family amino acid catabolic process (GO:0009071)2.60771470
165coenzyme catabolic process (GO:0009109)2.60629462
166ER to Golgi vesicle-mediated transport (GO:0006888)2.59830528
167triglyceride biosynthetic process (GO:0019432)2.59072318
168plasma lipoprotein particle organization (GO:0071827)2.58985587
169kynurenine metabolic process (GO:0070189)2.58917916
170neutral lipid biosynthetic process (GO:0046460)2.58522588
171acylglycerol biosynthetic process (GO:0046463)2.58522588
172negative regulation of GTPase activity (GO:0034260)2.58235725
173negative regulation of GTP catabolic process (GO:0033125)2.58235725
174peptide catabolic process (GO:0043171)2.58016187
175negative regulation of circadian rhythm (GO:0042754)2.57086752
176organelle fusion (GO:0048284)2.56057044
177fatty acid oxidation (GO:0019395)2.55755148
178very long-chain fatty acid metabolic process (GO:0000038)2.55059549
179peroxisome organization (GO:0007031)2.54464328
180regulation of stem cell maintenance (GO:2000036)2.54312654
181positive regulation of prostaglandin secretion (GO:0032308)2.53575915
182fatty-acyl-CoA biosynthetic process (GO:0046949)2.52488296
183neurotransmitter catabolic process (GO:0042135)2.52327459
184C-terminal protein amino acid modification (GO:0018410)2.52291715
185nonribosomal peptide biosynthetic process (GO:0019184)2.52127415
186fatty acid beta-oxidation (GO:0006635)2.50670847
187response to phenylpropanoid (GO:0080184)2.49744645
188long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.49559430
189negative regulation of sodium ion transport (GO:0010766)2.48968674
190phenylpropanoid metabolic process (GO:0009698)2.48806215
191phospholipid homeostasis (GO:0055091)2.48794008
192response to mercury ion (GO:0046689)2.48565902
193L-ascorbic acid metabolic process (GO:0019852)2.48476148
194cellular amino acid catabolic process (GO:0009063)2.48383141
195fatty acid catabolic process (GO:0009062)2.47506272
196sulfur compound transport (GO:0072348)2.46490215
197urea metabolic process (GO:0019627)2.46458153
198urea cycle (GO:0000050)2.46458153

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1NOTCH1_21737748_ChIP-Seq_TLL_Human4.92931258
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.88722111
3VDR_22108803_ChIP-Seq_LS180_Human4.69927521
4GATA1_22025678_ChIP-Seq_K562_Human4.67002658
5ZNF274_21170338_ChIP-Seq_K562_Hela4.61255082
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.31552496
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.15137427
8RXR_22158963_ChIP-Seq_LIVER_Mouse3.03800904
9HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.76779224
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.76307340
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65946125
12LXR_22158963_ChIP-Seq_LIVER_Mouse2.59630692
13* FLI1_27457419_Chip-Seq_LIVER_Mouse2.58410872
14RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.55932031
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.48194382
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.46834082
17IRF1_19129219_ChIP-ChIP_H3396_Human2.27183639
18IGF1R_20145208_ChIP-Seq_DFB_Human2.16246945
19* PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06026620
20PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.04923242
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.04341699
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.92028054
23SALL1_21062744_ChIP-ChIP_HESCs_Human1.88817713
24FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.86701592
25TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.80370103
26ETS1_20019798_ChIP-Seq_JURKAT_Human1.79401564
27VDR_23849224_ChIP-Seq_CD4+_Human1.76597420
28GBX2_23144817_ChIP-Seq_PC3_Human1.70727300
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.64718539
30JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.64307366
31TP53_22573176_ChIP-Seq_HFKS_Human1.63904099
32* SRF_21415370_ChIP-Seq_HL-1_Mouse1.63507829
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.63127995
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.62509299
35* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.59498885
36ELK1_19687146_ChIP-ChIP_HELA_Human1.59205560
37FUS_26573619_Chip-Seq_HEK293_Human1.59050845
38NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.57502171
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56598606
40* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52623373
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51157793
42ER_23166858_ChIP-Seq_MCF-7_Human1.50545468
43TP63_17297297_ChIP-ChIP_HaCaT_Human1.48611023
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.48368895
45FOXO3_23340844_ChIP-Seq_DLD1_Human1.47437843
46FOXP3_21729870_ChIP-Seq_TREG_Human1.47408845
47* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.46842264
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.45126350
49ZNF263_19887448_ChIP-Seq_K562_Human1.44827517
50FOXA1_27270436_Chip-Seq_PROSTATE_Human1.43704220
51FOXA1_25329375_ChIP-Seq_VCAP_Human1.43704220
52SOX2_20726797_ChIP-Seq_SW620_Human1.43160292
53FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.43123050
54MTF2_20144788_ChIP-Seq_MESCs_Mouse1.42331231
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40235693
56EZH2_22144423_ChIP-Seq_EOC_Human1.40214807
57TAF15_26573619_Chip-Seq_HEK293_Human1.39426388
58P300_19829295_ChIP-Seq_ESCs_Human1.38461845
59SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37958623
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.34278070
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33888905
62EWS_26573619_Chip-Seq_HEK293_Human1.32269207
63ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31477335
64TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.31407221
65GATA4_25053715_ChIP-Seq_YYC3_Human1.31228638
66* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31178202
67CBP_20019798_ChIP-Seq_JUKART_Human1.30921405
68IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.30921405
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.29905876
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.29816733
71* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28762718
72* NFE2_27457419_Chip-Seq_LIVER_Mouse1.28034508
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.26733496
74SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24447446
75EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23200854
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22420455
77EST1_17652178_ChIP-ChIP_JURKAT_Human1.22401326
78PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.22303648
79TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20678839
80POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20678839
81NCOR_22424771_ChIP-Seq_293T_Human1.20457702
82DROSHA_22980978_ChIP-Seq_HELA_Human1.19845978
83NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19483807
84CLOCK_20551151_ChIP-Seq_293T_Human1.19289349
85ESR1_20079471_ChIP-ChIP_T-47D_Human1.18681991
86ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18475762
87EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17413353
88TCF4_22108803_ChIP-Seq_LS180_Human1.16466890
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16276052
90PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.15729435
91TP63_23658742_ChIP-Seq_EP156T_Human1.15691030
92AR_20517297_ChIP-Seq_VCAP_Human1.13952168
93AR_21572438_ChIP-Seq_LNCaP_Human1.11504416
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11451900
95SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.11202650
96BCAT_22108803_ChIP-Seq_LS180_Human1.10960218
97GATA3_26560356_Chip-Seq_TH1_Human1.10785537
98ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10736056
99GATA3_21878914_ChIP-Seq_MCF-7_Human1.10243509
100MYC_18940864_ChIP-ChIP_HL60_Human1.09745099
101P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09244721
102FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09043837
103EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.08198725
104SUZ12_27294783_Chip-Seq_ESCs_Mouse1.07252630
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.06456957
106AHR_22903824_ChIP-Seq_MCF-7_Human1.05507835
107CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05497186
108* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.04544722
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.04544722
110PIAS1_25552417_ChIP-Seq_VCAP_Human1.04165830
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.03452431
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.03249537
113* EZH2_27294783_Chip-Seq_NPCs_Mouse1.02977225
114EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02626543
115RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02626543
116KLF5_25053715_ChIP-Seq_YYC3_Human1.01887347
117* GABP_19822575_ChIP-Seq_HepG2_Human1.01648304
118KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01443455
119GATA1_26923725_Chip-Seq_HPCs_Mouse1.01276624
120* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.99299573
121EZH2_27294783_Chip-Seq_ESCs_Mouse0.98908217
122* SOX2_19829295_ChIP-Seq_ESCs_Human0.98795180
123* NANOG_19829295_ChIP-Seq_ESCs_Human0.98795180
124CDX2_20551321_ChIP-Seq_CACO-2_Human0.98577363
125STAT3_23295773_ChIP-Seq_U87_Human0.98365224
126* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98093639
127AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97511550
128CDX2_22108803_ChIP-Seq_LS180_Human0.96355917
129SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.96064273
130* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96025511
131NANOG_20526341_ChIP-Seq_ESCs_Human0.95975744
132TP63_22573176_ChIP-Seq_HFKS_Human0.95369821
133CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94682777
134LXR_22292898_ChIP-Seq_THP-1_Human0.94382192
135JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.93995679
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93647594
137GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.93568681
138GATA2_19941826_ChIP-Seq_K562_Human0.92807727
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.92428102
140* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.92085643
141ESR1_21235772_ChIP-Seq_MCF-7_Human0.91998641
142SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91896329
143FOXH1_21741376_ChIP-Seq_EPCs_Human0.91589923
144GATA3_26560356_Chip-Seq_TH2_Human0.91425508
145FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.91413401
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.91280614
147* HNF4A_19822575_ChIP-Seq_HepG2_Human0.90749131
148HTT_18923047_ChIP-ChIP_STHdh_Human0.90316730
149GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90093507
150TP53_18474530_ChIP-ChIP_U2OS_Human0.90075175
151CJUN_26792858_Chip-Seq_BT549_Human0.89901376
152IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88155235
153PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.87751178
154MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87282041
155NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.86732890
156OCT4_20526341_ChIP-Seq_ESCs_Human0.86465129
157EP300_21415370_ChIP-Seq_HL-1_Mouse0.86042953
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85941030
159* STAT3_18555785_Chip-Seq_ESCs_Mouse0.85245152
160SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.85123999
161RXR_22108803_ChIP-Seq_LS180_Human0.84541169
162* CRX_20693478_ChIP-Seq_RETINA_Mouse0.84407005
163THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84161737
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.83717894
165* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.83579798
166WDR5_24793694_ChIP-Seq_LNCAP_Human0.83136306
167AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82648685
168SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82503066
169SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81954499
170TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.81747667
171TET1_21490601_ChIP-Seq_MESCs_Mouse0.81723044
172TCF4_18268006_ChIP-ChIP_LS174T_Human0.81503744
173JARID2_20075857_ChIP-Seq_MESCs_Mouse0.81400394
174SMAD4_21741376_ChIP-Seq_EPCs_Human0.81081805
175RARG_19884340_ChIP-ChIP_MEFs_Mouse0.80929212
176RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80865144
177* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.80799910
178* RACK7_27058665_Chip-Seq_MCF-7_Human0.80502101
179CTBP2_25329375_ChIP-Seq_LNCAP_Human0.79779505
180KDM2B_26808549_Chip-Seq_K562_Human0.78907046
181TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78312864
182PRDM14_20953172_ChIP-Seq_ESCs_Human0.77882916
183RNF2_27304074_Chip-Seq_ESCs_Mouse0.77554328
184FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.77526959
185NR3C1_23031785_ChIP-Seq_PC12_Mouse0.77075444
186* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76818568
187ATF3_27146783_Chip-Seq_COLON_Human0.76792157
188GATA6_25053715_ChIP-Seq_YYC3_Human0.76552406
189P300_27058665_Chip-Seq_ZR-75-30cells_Human0.76283212
190ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.75448329

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis6.62818266
2MP0000566_synostosis6.04509627
3MP0002139_abnormal_hepatobiliary_system4.83805819
4MP0010234_abnormal_vibrissa_follicle3.84881682
5MP0003303_peritoneal_inflammation3.79605631
6MP0009840_abnormal_foam_cell3.32871668
7MP0003329_amyloid_beta_deposits3.15109560
8MP0008875_abnormal_xenobiotic_pharmacok2.93167247
9MP0005332_abnormal_amino_acid2.83229453
10MP0001666_abnormal_nutrient_absorption2.59385321
11MP0005365_abnormal_bile_salt2.52749217
12MP0001919_abnormal_reproductive_system2.52672513
13MP0004858_abnormal_nervous_system2.52410799
14MP0002876_abnormal_thyroid_physiology2.51674494
15MP0005085_abnormal_gallbladder_physiolo2.51039975
16MP0003252_abnormal_bile_duct2.50357607
17MP0004019_abnormal_vitamin_homeostasis2.41978226
18MP0000604_amyloidosis2.38502217
19MP0003806_abnormal_nucleotide_metabolis2.33078816
20MP0006082_CNS_inflammation2.25693844
21MP0004043_abnormal_pH_regulation2.05581760
22MP0003787_abnormal_imprinting1.93249695
23MP0010329_abnormal_lipoprotein_level1.92699340
24MP0003300_gastrointestinal_ulcer1.89470988
25MP0005389_reproductive_system_phenotype1.86954099
26MP0009643_abnormal_urine_homeostasis1.86769549
27MP0001984_abnormal_olfaction1.83653478
28MP0003656_abnormal_erythrocyte_physiolo1.82716158
29MP0003690_abnormal_glial_cell1.81869872
30MP0002751_abnormal_autonomic_nervous1.78529773
31MP0005058_abnormal_lysosome_morphology1.78377123
32MP0002796_impaired_skin_barrier1.77393308
33MP0005670_abnormal_white_adipose1.75241250
34MP0002102_abnormal_ear_morphology1.69357194
35MP0001765_abnormal_ion_homeostasis1.69316894
36MP0008877_abnormal_DNA_methylation1.62120562
37MP0002138_abnormal_hepatobiliary_system1.61928532
38MP0005377_hearing/vestibular/ear_phenot1.60295683
39MP0003878_abnormal_ear_physiology1.60295683
40MP0009384_cardiac_valve_regurgitation1.59008830
41MP0003075_altered_response_to1.57849787
42MP0005636_abnormal_mineral_homeostasis1.57399846
43MP0000467_abnormal_esophagus_morphology1.56805388
44MP0005084_abnormal_gallbladder_morpholo1.55927810
45MP0003705_abnormal_hypodermis_morpholog1.54150553
46MP0002254_reproductive_system_inflammat1.52554071
47MP0005451_abnormal_body_composition1.51609875
48MP0004885_abnormal_endolymph1.51508183
49MP0001764_abnormal_homeostasis1.49731021
50MP0004270_analgesia1.48429903
51MP0002277_abnormal_respiratory_mucosa1.47410382
52MP0001756_abnormal_urination1.46907205
53MP0008872_abnormal_physiological_respon1.46246735
54MP0001986_abnormal_taste_sensitivity1.43860330
55MP0003718_maternal_effect1.38061730
56MP0002822_catalepsy1.37186779
57MP0005408_hypopigmentation1.35894981
58MP0000538_abnormal_urinary_bladder1.35054503
59MP0003122_maternal_imprinting1.34994808
60MP0003011_delayed_dark_adaptation1.34832193
61MP0005645_abnormal_hypothalamus_physiol1.34059439
62MP0002163_abnormal_gland_morphology1.31777330
63MP0005083_abnormal_biliary_tract1.30953173
64MP0009780_abnormal_chondrocyte_physiolo1.30460297
65MP0005551_abnormal_eye_electrophysiolog1.30347906
66MP0000462_abnormal_digestive_system1.29823756
67MP0006054_spinal_hemorrhage1.26495368
68MP0000579_abnormal_nail_morphology1.22513342
69MP0002136_abnormal_kidney_physiology1.22064839
70MP0002118_abnormal_lipid_homeostasis1.20914369
71MP0005584_abnormal_enzyme/coenzyme_acti1.20721879
72MP0005379_endocrine/exocrine_gland_phen1.19941549
73MP0004782_abnormal_surfactant_physiolog1.18114777
74MP0004859_abnormal_synaptic_plasticity1.17807029
75MP0005310_abnormal_salivary_gland1.15552568
76MP0005666_abnormal_adipose_tissue1.13664039
77MP0010678_abnormal_skin_adnexa1.13268004
78MP0003115_abnormal_respiratory_system1.13069113
79MP0003121_genomic_imprinting1.12391037
80MP0000609_abnormal_liver_physiology1.09585887
81MP0002638_abnormal_pupillary_reflex1.09422729
82MP0002295_abnormal_pulmonary_circulatio1.08477073
83MP0002734_abnormal_mechanical_nocicepti1.08326989
84MP0003868_abnormal_feces_composition1.08148731
85MP0008058_abnormal_DNA_repair1.07694297
86MP0005253_abnormal_eye_physiology1.07591766
87MP0003937_abnormal_limbs/digits/tail_de1.06016313
88MP0003191_abnormal_cellular_cholesterol1.05876122
89MP0005166_decreased_susceptibility_to1.05835941
90MP0004142_abnormal_muscle_tone1.05665077
91MP0008961_abnormal_basal_metabolism1.05470992
92MP0004147_increased_porphyrin_level1.04809736
93MP0001293_anophthalmia1.04328445
94MP0003195_calcinosis1.03168621
95MP0000490_abnormal_crypts_of1.03141686
96MP0006276_abnormal_autonomic_nervous1.01750868
97MP0001286_abnormal_eye_development1.00609991
98MP0003634_abnormal_glial_cell0.92666670
99MP0001529_abnormal_vocalization0.92338570
100MP0006292_abnormal_olfactory_placode0.92241036
101MP0008995_early_reproductive_senescence0.91691611
102MP0005319_abnormal_enzyme/_coenzyme0.89650973
103MP0004264_abnormal_extraembryonic_tissu0.86971765
104MP0000470_abnormal_stomach_morphology0.85750993
105MP0002210_abnormal_sex_determination0.84973505
106MP0005395_other_phenotype0.82919008
107MP0003183_abnormal_peptide_metabolism0.82757879
108MP0004185_abnormal_adipocyte_glucose0.81898266
109MP0001485_abnormal_pinna_reflex0.79364484
110MP0002909_abnormal_adrenal_gland0.78695716
111MP0002160_abnormal_reproductive_system0.78540620
112MP0002234_abnormal_pharynx_morphology0.78367506
113MP0003632_abnormal_nervous_system0.78225366
114MP0002733_abnormal_thermal_nociception0.76762494
115MP0000920_abnormal_myelination0.75328289
116MP0003890_abnormal_embryonic-extraembry0.75172964
117MP0001929_abnormal_gametogenesis0.74805740
118MP0002098_abnormal_vibrissa_morphology0.74768469
119MP0001440_abnormal_grooming_behavior0.74757855
120MP0003724_increased_susceptibility_to0.74357144
121MP0005381_digestive/alimentary_phenotyp0.74073101
122MP0003638_abnormal_response/metabolism_0.73860946
123MP0001664_abnormal_digestion0.73855916
124MP0005410_abnormal_fertilization0.73749128
125MP0008789_abnormal_olfactory_epithelium0.73425150
126MP0000372_irregular_coat_pigmentation0.71423755
127MP0005075_abnormal_melanosome_morpholog0.71418402
128MP0009764_decreased_sensitivity_to0.69620745
129MP0005195_abnormal_posterior_eye0.69509890
130MP0005671_abnormal_response_to0.69302723
131MP0005448_abnormal_energy_balance0.69271448
132MP0004130_abnormal_muscle_cell0.69205921
133MP0010155_abnormal_intestine_physiology0.68976191
134MP0003763_abnormal_thymus_physiology0.68696565
135MP0003567_abnormal_fetal_cardiomyocyte0.68425873
136MP0000653_abnormal_sex_gland0.67951165
137MP0001663_abnormal_digestive_system0.67686198
138MP0006072_abnormal_retinal_apoptosis0.65549966
139MP0000026_abnormal_inner_ear0.65005135
140MP0000477_abnormal_intestine_morphology0.64825834
141MP0000427_abnormal_hair_cycle0.64220866
142MP0001963_abnormal_hearing_physiology0.63585699
143MP0003786_premature_aging0.63450637
144MP0001905_abnormal_dopamine_level0.63077559
145MP0001145_abnormal_male_reproductive0.62328237
146MP0001915_intracranial_hemorrhage0.62136591
147MP0004484_altered_response_of0.61989064
148MP0001873_stomach_inflammation0.61983946
149MP0005394_taste/olfaction_phenotype0.61846215
150MP0005499_abnormal_olfactory_system0.61846215
151MP0003631_nervous_system_phenotype0.61659102
152MP0005501_abnormal_skin_physiology0.61545837
153MP0003633_abnormal_nervous_system0.59082393
154MP0005647_abnormal_sex_gland0.58461590
155MP0001958_emphysema0.56740741
156MP0002090_abnormal_vision0.56446080
157MP0008874_decreased_physiological_sensi0.55849458
158MP0004924_abnormal_behavior0.55231811
159MP0005386_behavior/neurological_phenoty0.55231811
160MP0002229_neurodegeneration0.55072997
161MP0000383_abnormal_hair_follicle0.52891442
162MP0003866_abnormal_defecation0.51404192
163MP0009642_abnormal_blood_homeostasis0.51156285
164MP0003566_abnormal_cell_adhesion0.50647271
165MP0002089_abnormal_postnatal_growth/wei0.50484106
166MP0002069_abnormal_eating/drinking_beha0.50124014
167MP0002971_abnormal_brown_adipose0.49319496

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the renal collecting system (HP:0004742)6.01555456
2Duplicated collecting system (HP:0000081)5.97925661
3Abnormality of long-chain fatty-acid metabolism (HP:0010964)5.92068610
4Large for gestational age (HP:0001520)4.90697095
5Neurofibrillary tangles (HP:0002185)4.74563092
6Hyperglycinuria (HP:0003108)4.70316223
7Abnormality of glutamine family amino acid metabolism (HP:0010902)4.62219022
8Cerebral inclusion bodies (HP:0100314)4.41592271
9Long foot (HP:0001833)4.34744346
10Abnormality of glycine metabolism (HP:0010895)4.32137384
11Abnormality of serine family amino acid metabolism (HP:0010894)4.32137384
12Gout (HP:0001997)3.89661295
13Ketoacidosis (HP:0001993)3.81304452
14Hydroxyprolinuria (HP:0003080)3.65386023
15Abnormality of proline metabolism (HP:0010907)3.65386023
16Xanthomatosis (HP:0000991)3.59819501
17Ketosis (HP:0001946)3.59232958
18Adactyly (HP:0009776)3.50496633
19Brushfield spots (HP:0001088)3.44953868
20Increased circulating renin level (HP:0000848)3.32814335
21Acute lymphatic leukemia (HP:0006721)3.31414106
22Abnormal urine output (HP:0012590)3.25315615
23Potter facies (HP:0002009)3.24684527
24Facial shape deformation (HP:0011334)3.24684527
25Metabolic alkalosis (HP:0200114)3.21659140
26Abnormality of renal excretion (HP:0011036)3.11173024
27Deep venous thrombosis (HP:0002625)3.09988177
28Abnormality of chloride homeostasis (HP:0011422)3.06598200
29Hyperactive renin-angiotensin system (HP:0000841)3.03085040
30Severe muscular hypotonia (HP:0006829)3.02061414
31Abnormality of purine metabolism (HP:0004352)2.92680971
32Abnormality of sulfur amino acid metabolism (HP:0004339)2.90143866
33Intrahepatic cholestasis (HP:0001406)2.88024960
34Ureteral duplication (HP:0000073)2.87476000
35Vacuolated lymphocytes (HP:0001922)2.86378344
36Hypomagnesemia (HP:0002917)2.84303467
37Polyuria (HP:0000103)2.79435490
38Hypokalemic alkalosis (HP:0001949)2.78246669
39Megalencephaly (HP:0001355)2.76621241
40Hypoplastic pelvis (HP:0008839)2.76103053
41Male infertility (HP:0003251)2.76037152
42Hyperammonemia (HP:0001987)2.75971815
43Hyperglycinemia (HP:0002154)2.73733606
44Aplasia involving bones of the extremities (HP:0009825)2.72261966
45Aplasia involving bones of the upper limbs (HP:0009823)2.72261966
46Aplasia of the phalanges of the hand (HP:0009802)2.72261966
47Progressive muscle weakness (HP:0003323)2.71776060
48Conjugated hyperbilirubinemia (HP:0002908)2.70360897
49Broad-based gait (HP:0002136)2.70087035
50Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69482585
51Abnormality of alanine metabolism (HP:0010916)2.69482585
52Hyperalaninemia (HP:0003348)2.69482585
53Sensorimotor neuropathy (HP:0007141)2.68270746
54Supranuclear gaze palsy (HP:0000605)2.68124283
55Glycosuria (HP:0003076)2.66331166
56Abnormality of urine glucose concentration (HP:0011016)2.66331166
57Malnutrition (HP:0004395)2.65666780
58Hyperlipoproteinemia (HP:0010980)2.59096853
59Hypoplastic nipples (HP:0002557)2.53124654
60Abnormality of monocarboxylic acid metabolism (HP:0010996)2.52931313
61Wide intermamillary distance (HP:0006610)2.52052240
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.51973935
63Dry hair (HP:0011359)2.50844584
64Abnormality of magnesium homeostasis (HP:0004921)2.50237839
65Ureteral stenosis (HP:0000071)2.47907265
66Clubbing of toes (HP:0100760)2.47869621
67Decreased circulating renin level (HP:0003351)2.43446893
68Molar tooth sign on MRI (HP:0002419)2.38878182
69Abnormality of midbrain morphology (HP:0002418)2.38878182
70Hyperuricemia (HP:0002149)2.37051753
71Increased purine levels (HP:0004368)2.37051753
72Polydipsia (HP:0001959)2.35861229
73Abnormal drinking behavior (HP:0030082)2.35861229
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.29708800
75Dehydration (HP:0001944)2.29669128
76Back pain (HP:0003418)2.28785637
77Amyloidosis (HP:0011034)2.28501292
78Ureteral obstruction (HP:0006000)2.24980938
79Widely spaced teeth (HP:0000687)2.24717726
80Abnormality of the renal cortex (HP:0011035)2.24452970
81Vascular calcification (HP:0004934)2.23959394
82Prolonged partial thromboplastin time (HP:0003645)2.23834206
83Abnormality of nucleobase metabolism (HP:0010932)2.23754892
84Polymicrogyria (HP:0002126)2.23224406
85Epiphyseal stippling (HP:0010655)2.20124888
86Abolished electroretinogram (ERG) (HP:0000550)2.19673943
87Pendular nystagmus (HP:0012043)2.19459541
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.19444145
89Nephrolithiasis (HP:0000787)2.18696911
90Lipid accumulation in hepatocytes (HP:0006561)2.18593685
91Anhidrosis (HP:0000970)2.17873575
92Dysostosis multiplex (HP:0000943)2.17679998
93Ileus (HP:0002595)2.16077536
94Steatorrhea (HP:0002570)2.15566155
95Abnormality of fatty-acid metabolism (HP:0004359)2.14657815
96Chronic hepatic failure (HP:0100626)2.12662892
97Pancreatic cysts (HP:0001737)2.12542833
98Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.12436428
99Delayed CNS myelination (HP:0002188)2.10275237
100Generalized aminoaciduria (HP:0002909)2.09223382
101Progressive inability to walk (HP:0002505)2.07803731
102Cholecystitis (HP:0001082)2.06223221
103Abnormal gallbladder physiology (HP:0012438)2.06223221
104Metabolic acidosis (HP:0001942)2.06007926
105Medial flaring of the eyebrow (HP:0010747)2.05873385
106Cardiovascular calcification (HP:0011915)2.04966030
107Female pseudohermaphroditism (HP:0010458)2.04005064
108Hypobetalipoproteinemia (HP:0003563)2.03919362
109Lactic acidosis (HP:0003128)2.03728418
110Methylmalonic aciduria (HP:0012120)2.02236114
111Fat malabsorption (HP:0002630)2.01562173
112Partial agenesis of the corpus callosum (HP:0001338)2.01314787
113Increased hepatocellular lipid droplets (HP:0006565)2.00981664
114Mesangial abnormality (HP:0001966)2.00820992
115Congenital stationary night blindness (HP:0007642)2.00532075
116Curly hair (HP:0002212)2.00413098
117Hyperphosphaturia (HP:0003109)2.00146162
118Renal cortical cysts (HP:0000803)2.00114983
119Attenuation of retinal blood vessels (HP:0007843)1.99975868
120Global brain atrophy (HP:0002283)1.99757681
121Autoamputation (HP:0001218)1.99373785
122Abnormal rod and cone electroretinograms (HP:0008323)1.99311781
123Palmoplantar hyperkeratosis (HP:0000972)1.98678450
124Type II lissencephaly (HP:0007260)1.98652490
125Proximal tubulopathy (HP:0000114)1.98512772
126True hermaphroditism (HP:0010459)1.98198410
127Renal tubular acidosis (HP:0001947)1.98007334
128Alkalosis (HP:0001948)1.97979322
129Acanthocytosis (HP:0001927)1.96169124
130Widely patent fontanelles and sutures (HP:0004492)1.95512795
131Palmar hyperkeratosis (HP:0010765)1.93286389
132Nephronophthisis (HP:0000090)1.93146363
133Bilateral microphthalmos (HP:0007633)1.91820848
134Mucopolysacchariduria (HP:0008155)1.91570896
135Urinary glycosaminoglycan excretion (HP:0003541)1.91570896
136Abnormality of renin-angiotensin system (HP:0000847)1.91197269
137Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91117173
138Abnormality of polysaccharide metabolism (HP:0011012)1.91117173
139Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91117173
140Pancreatic islet-cell hyperplasia (HP:0004510)1.89779865
141Scrotal hypoplasia (HP:0000046)1.89550891
142Pancreatic fibrosis (HP:0100732)1.89017266
143Abnormality of the pons (HP:0007361)1.88414319
144Chorioretinal atrophy (HP:0000533)1.84326633
145Abnormal urine phosphate concentration (HP:0012599)1.83357512
146Protuberant abdomen (HP:0001538)1.83316501
147Spastic paraparesis (HP:0002313)1.82957349
148Paraparesis (HP:0002385)1.81820145
149Confusion (HP:0001289)1.81573803
150Polyphagia (HP:0002591)1.81299594
151Broad alveolar ridges (HP:0000187)1.80735684
152Tetany (HP:0001281)1.80505426
153Increased number of teeth (HP:0011069)1.79601555
1543-Methylglutaconic aciduria (HP:0003535)1.78894398
155Retrobulbar optic neuritis (HP:0100654)1.78169635
156Optic neuritis (HP:0100653)1.78169635
157Neonatal onset (HP:0003623)1.77961300
158Hyperventilation (HP:0002883)1.77749928
159Abnormality of the renal medulla (HP:0100957)1.77011533
160Concave nail (HP:0001598)1.76100452
161Irritability (HP:0000737)1.75995829
162Hypoplastic iliac wings (HP:0002866)1.75841284
163Cone-rod dystrophy (HP:0000548)1.75592294
164Nephrogenic diabetes insipidus (HP:0009806)1.75173147
165Spastic diplegia (HP:0001264)1.74597604
166Akinesia (HP:0002304)1.74519480
167Lissencephaly (HP:0001339)1.73954519
168Increased serum lactate (HP:0002151)1.73798759
169Methylmalonic acidemia (HP:0002912)1.73298503
170Hypercalciuria (HP:0002150)1.73067672
171Short hallux (HP:0010109)1.72801222
172Pheochromocytoma (HP:0002666)1.72710016
173Retinitis pigmentosa (HP:0000510)1.72505135
174Thickened nuchal skin fold (HP:0000474)1.72100940
175Fibular aplasia (HP:0002990)1.71988408
17611 pairs of ribs (HP:0000878)1.71874681
177Abnormality of DNA repair (HP:0003254)1.71589154
178Bony spicule pigmentary retinopathy (HP:0007737)1.70599049
179Tubular atrophy (HP:0000092)1.69951884
180Plantar hyperkeratosis (HP:0007556)1.66270804
181Polyneuropathy (HP:0001271)1.65927667
182Menstrual irregularities (HP:0000858)1.63343856
183Inability to walk (HP:0002540)1.62495611
184Abnormality of vision evoked potentials (HP:0000649)1.57971996
185Hypoplasia of the pons (HP:0012110)1.56069235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK29.28125886
2MKNK15.40014231
3TAOK14.57746942
4LMTK24.29020472
5TAOK23.96409374
6MAP3K113.28170304
7MAP2K32.84908317
8WNK42.73214219
9MAP3K32.72345491
10OXSR12.65883516
11ARAF2.49078742
12EPHA42.48595291
13ACVR1B2.48412282
14STK392.47240692
15MAP3K92.36620889
16PHKG22.33664995
17PHKG12.33664995
18KSR22.16741520
19EIF2AK32.15311820
20MST1R2.07941715
21MAP3K61.90813522
22TRIB31.86944598
23TAOK31.82062409
24JAK31.78568016
25MAP3K131.77991591
26SIK11.74835263
27MARK11.71687132
28ERN11.65812966
29SCYL21.61926168
30MAP4K21.60224132
31PDK41.58205249
32PDK31.58205249
33MAP3K21.55960174
34FRK1.55711870
35MOS1.48030713
36NTRK11.45322936
37EEF2K1.45128017
38DYRK1A1.44912211
39LATS11.40007000
40SRPK11.38387325
41GRK61.37592321
42MAP3K51.36972962
43WNK31.35811707
44ADRBK21.33750395
45LRRK21.31565858
46ZAK1.25162767
47NUAK11.24999043
48NTRK21.22834999
49BCR1.21349074
50TXK1.20745147
51LATS21.16537237
52DYRK21.16381523
53PAK31.11329170
54BRAF1.09829872
55BCKDK1.08163580
56STK101.06551620
57TYK21.05106985
58PAK61.02971490
59RAF11.01495215
60PIK3CA1.00110063
61ERBB40.99116081
62MET0.98746396
63INSRR0.98357296
64STK38L0.94804590
65DAPK20.94580529
66RET0.94041209
67EPHB10.92518823
68MAP3K40.92424156
69MAP3K100.92016120
70SGK4940.90950845
71SGK2230.90950845
72PDPK10.88438892
73MAP2K10.85834720
74MINK10.82996007
75GRK10.82736184
76PDK20.81755651
77MAPK150.80990772
78WNK10.80443304
79EPHB20.79279987
80CSNK1G20.79081199
81PTK60.77957997
82ROCK20.76451592
83ICK0.76023202
84CHEK20.74429051
85BMPR1B0.73819212
86LIMK10.71419557
87SGK30.70509183
88MAP2K60.70384256
89FGR0.70216065
90CSNK1G30.69701124
91CASK0.69541912
92VRK10.67610581
93CSNK1G10.63928008
94MAPKAPK30.63127273
95KSR10.62215833
96PRKCZ0.62094383
97PDK10.60943979
98EPHA30.60700892
99PRKAA10.60652963
100EIF2AK20.60623489
101AKT30.60360436
102TLK10.60285288
103BUB10.60179327
104MST40.59275984
105TRIM280.59254602
106FLT30.58968052
107ERBB30.58626852
108ROCK10.57817070
109EPHA20.55784277
110TNIK0.54741404
111ABL20.54231045
112PRKAA20.53820701
113MAP2K40.53215755
114MAP3K10.52592653
115TSSK60.52138951
116SGK20.51480917
117TESK10.50523894
118DDR20.50368673
119CDK50.49481140
120MATK0.48986980
121CSNK1A1L0.47720937
122MAPK130.47257583
123PTK20.46511483
124TYRO30.46007005
125CAMKK20.45690916
126PRKCQ0.45593978
127NME10.45359585
128FER0.43823403
129ILK0.43481539
130MAP2K70.43127013
131MAP4K10.42886218
132MAPK120.41739278
133PRKCI0.40108604
134RIPK10.39610062
135FGFR40.39185629
136STK160.39074611
137MAP2K20.37826162
138FYN0.37684602
139MAP3K80.37366587
140ABL10.37174679
141BMPR20.36572680
142PRKD30.36149075
143PRKCE0.33055845
144IGF1R0.32412819
145IRAK10.30523231
146DYRK30.30003660
147RPS6KA40.29786557
148PLK40.29691094
149IKBKE0.29255272
150CSNK1A10.28177911
151IKBKB0.27429046
152MUSK0.26429866
153SIK30.26108182
154ITK0.25479514
155KIT0.24361630
156CHUK0.22539530
157PLK30.19756513
158PINK10.19328602
159CSF1R0.18515509
160FES0.18094634
161EIF2AK10.17570960
162ADRBK10.17388685
163BRSK20.16448856
164ATR0.15594244
165LCK0.14919437
166TEC0.13439913
167NEK10.12554973
168CSNK2A10.12140197
169PRKCD0.11459318
170YES10.09968481
171PIM10.08882143
172LYN0.07337327
173FGFR20.07097119
174CSNK1E0.06450418

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.03221316
2Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.82633256
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.79238999
4SNARE interactions in vesicular transport_Homo sapiens_hsa041302.78874437
5Nitrogen metabolism_Homo sapiens_hsa009102.68393852
6Fatty acid degradation_Homo sapiens_hsa000712.64454880
7Propanoate metabolism_Homo sapiens_hsa006402.31081404
8Bile secretion_Homo sapiens_hsa049762.17957210
9Sulfur metabolism_Homo sapiens_hsa009202.15806217
10RNA polymerase_Homo sapiens_hsa030202.14526356
11Fatty acid metabolism_Homo sapiens_hsa012122.12817605
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.10646482
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.08000067
14Fatty acid biosynthesis_Homo sapiens_hsa000612.04973851
15PPAR signaling pathway_Homo sapiens_hsa033201.99256555
16Caffeine metabolism_Homo sapiens_hsa002321.96000376
17Butanoate metabolism_Homo sapiens_hsa006501.95741480
18Tryptophan metabolism_Homo sapiens_hsa003801.93118792
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87416129
20Histidine metabolism_Homo sapiens_hsa003401.82448344
21Peroxisome_Homo sapiens_hsa041461.76285291
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.71096514
23Maturity onset diabetes of the young_Homo sapiens_hsa049501.69424523
24Pyruvate metabolism_Homo sapiens_hsa006201.69378443
25One carbon pool by folate_Homo sapiens_hsa006701.63961730
26Vitamin digestion and absorption_Homo sapiens_hsa049771.63228968
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.62004058
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.61031003
29Mineral absorption_Homo sapiens_hsa049781.57106295
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57021688
31Arginine biosynthesis_Homo sapiens_hsa002201.52896986
32Phototransduction_Homo sapiens_hsa047441.50484532
33Primary bile acid biosynthesis_Homo sapiens_hsa001201.44214885
34beta-Alanine metabolism_Homo sapiens_hsa004101.43731045
35Steroid biosynthesis_Homo sapiens_hsa001001.42394408
36Fanconi anemia pathway_Homo sapiens_hsa034601.42061109
37Glycerolipid metabolism_Homo sapiens_hsa005611.41370491
38Fat digestion and absorption_Homo sapiens_hsa049751.38373311
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.37486129
40Renin-angiotensin system_Homo sapiens_hsa046141.33661798
412-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.31097677
42Taste transduction_Homo sapiens_hsa047421.28894610
43Arginine and proline metabolism_Homo sapiens_hsa003301.28745517
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25119063
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21097657
46Starch and sucrose metabolism_Homo sapiens_hsa005001.13775758
47Carbohydrate digestion and absorption_Homo sapiens_hsa049731.10562909
48Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.06552450
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04809869
50Arachidonic acid metabolism_Homo sapiens_hsa005901.03700602
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.02565310
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.99982490
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.99109622
54Protein export_Homo sapiens_hsa030600.98854268
55Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96714567
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.90602500
57Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.90083301
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88681544
59Basal transcription factors_Homo sapiens_hsa030220.88677255
60Fatty acid elongation_Homo sapiens_hsa000620.88252180
61Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.84798443
62Carbon metabolism_Homo sapiens_hsa012000.83667767
63Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.82315162
64Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82295909
65Proteasome_Homo sapiens_hsa030500.82255230
66ABC transporters_Homo sapiens_hsa020100.80987996
67Folate biosynthesis_Homo sapiens_hsa007900.79855298
68Sphingolipid metabolism_Homo sapiens_hsa006000.77175165
69Glycerophospholipid metabolism_Homo sapiens_hsa005640.76287550
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.75517772
71Protein digestion and absorption_Homo sapiens_hsa049740.74285255
72Chemical carcinogenesis_Homo sapiens_hsa052040.73244846
73Steroid hormone biosynthesis_Homo sapiens_hsa001400.71790844
74Ovarian steroidogenesis_Homo sapiens_hsa049130.71313857
75Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70962533
76Olfactory transduction_Homo sapiens_hsa047400.69701968
77alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68703417
78Gastric acid secretion_Homo sapiens_hsa049710.68673871
79Glutathione metabolism_Homo sapiens_hsa004800.68616955
80Lysosome_Homo sapiens_hsa041420.67627301
81Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.66834352
82Drug metabolism - other enzymes_Homo sapiens_hsa009830.63565270
83Complement and coagulation cascades_Homo sapiens_hsa046100.62899356
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.62605275
85Other glycan degradation_Homo sapiens_hsa005110.60860652
86Thyroid hormone synthesis_Homo sapiens_hsa049180.59601722
87Biosynthesis of amino acids_Homo sapiens_hsa012300.58447506
88Phenylalanine metabolism_Homo sapiens_hsa003600.57565450
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56983215
90Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54727793
91Ether lipid metabolism_Homo sapiens_hsa005650.53304568
92Collecting duct acid secretion_Homo sapiens_hsa049660.52987606
93Nucleotide excision repair_Homo sapiens_hsa034200.51579128
94Pyrimidine metabolism_Homo sapiens_hsa002400.50377039
95Homologous recombination_Homo sapiens_hsa034400.50290897
96Pentose phosphate pathway_Homo sapiens_hsa000300.48275565
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46099814
98RNA transport_Homo sapiens_hsa030130.44629239
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44394153
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.44325856
101Fructose and mannose metabolism_Homo sapiens_hsa000510.44067917
102Endometrial cancer_Homo sapiens_hsa052130.42760312
103RNA degradation_Homo sapiens_hsa030180.42091518
104Salivary secretion_Homo sapiens_hsa049700.41905676
105Purine metabolism_Homo sapiens_hsa002300.41380805
106Selenocompound metabolism_Homo sapiens_hsa004500.40896265
107Retinol metabolism_Homo sapiens_hsa008300.40684735
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.39819968
109Oxidative phosphorylation_Homo sapiens_hsa001900.39179652
110Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.38907792
111Lysine degradation_Homo sapiens_hsa003100.37528418
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37205782
113Pancreatic cancer_Homo sapiens_hsa052120.37183546
114Insulin resistance_Homo sapiens_hsa049310.36643137
115Linoleic acid metabolism_Homo sapiens_hsa005910.34003620
116Metabolic pathways_Homo sapiens_hsa011000.33431096
117Sphingolipid signaling pathway_Homo sapiens_hsa040710.33163755
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33098147
119Primary immunodeficiency_Homo sapiens_hsa053400.32820379
120Sulfur relay system_Homo sapiens_hsa041220.32735413
121Pancreatic secretion_Homo sapiens_hsa049720.32558938
122Tyrosine metabolism_Homo sapiens_hsa003500.31344207
123Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30939852
124Nicotine addiction_Homo sapiens_hsa050330.30308105
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.30275734
126N-Glycan biosynthesis_Homo sapiens_hsa005100.30076290
127Bladder cancer_Homo sapiens_hsa052190.29492758
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.28012633
129Galactose metabolism_Homo sapiens_hsa000520.26002279
130Glycosaminoglycan degradation_Homo sapiens_hsa005310.25802033
131Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.24840328
132Hepatitis C_Homo sapiens_hsa051600.24692227
133Choline metabolism in cancer_Homo sapiens_hsa052310.24667207
134Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.23588747
135GnRH signaling pathway_Homo sapiens_hsa049120.23472736

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