MGAM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes maltase-glucoamylase, which is a brush border membrane enzyme that plays a role in the final steps of digestion of starch. The protein has two catalytic sites identical to those of sucrase-isomaltase, but the proteins are only 59% homologous. Both are members of glycosyl hydrolase family 31, which has a variety of substrate specificities. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1intestinal absorption (GO:0050892)9.91118438
2angiotensin maturation (GO:0002003)8.48348360
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.75752302
4drug catabolic process (GO:0042737)5.89306691
5phospholipid efflux (GO:0033700)5.76324331
6regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)5.73370972
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.68861349
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.68861349
9modulation by symbiont of host immune response (GO:0052553)5.68861349
10positive regulation by symbiont of host defense response (GO:0052509)5.68861349
11modulation by symbiont of host defense response (GO:0052031)5.68861349
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.68861349
13regulation of triglyceride catabolic process (GO:0010896)5.67297420
14regulation of cholesterol esterification (GO:0010872)5.63339573
15regulation of bile acid biosynthetic process (GO:0070857)5.62471459
16plasma lipoprotein particle assembly (GO:0034377)5.51100108
17flavonoid metabolic process (GO:0009812)5.47065412
18cholesterol efflux (GO:0033344)5.34045103
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.33143218
20very-low-density lipoprotein particle assembly (GO:0034379)5.19502469
21protein-lipid complex assembly (GO:0065005)5.16803901
22positive regulation of lipoprotein lipase activity (GO:0051006)5.13953640
23positive regulation of triglyceride lipase activity (GO:0061365)5.13953640
24negative regulation of cholesterol transport (GO:0032375)5.08374662
25negative regulation of sterol transport (GO:0032372)5.08374662
26urea cycle (GO:0000050)5.05972515
27urea metabolic process (GO:0019627)5.05972515
28negative regulation of cell killing (GO:0031342)5.05193126
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.05193126
30lipoprotein metabolic process (GO:0042157)5.03425269
31antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.90048186
32high-density lipoprotein particle remodeling (GO:0034375)4.85989875
33reverse cholesterol transport (GO:0043691)4.80829079
34detection of other organism (GO:0098543)4.79671644
35antigen processing and presentation of endogenous antigen (GO:0019883)4.74079813
36detection of molecule of bacterial origin (GO:0032490)4.73411291
37cholesterol homeostasis (GO:0042632)4.73259027
38positive regulation of gamma-delta T cell activation (GO:0046645)4.72324446
39macrophage activation involved in immune response (GO:0002281)4.69529103
40sterol homeostasis (GO:0055092)4.67487814
41protein-lipid complex remodeling (GO:0034368)4.60181237
42macromolecular complex remodeling (GO:0034367)4.60181237
43plasma lipoprotein particle remodeling (GO:0034369)4.60181237
44nitrogen cycle metabolic process (GO:0071941)4.57031061
45antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.53632750
46regulation of interferon-beta biosynthetic process (GO:0045357)4.53452613
47hormone catabolic process (GO:0042447)4.50966386
48vitamin A metabolic process (GO:0006776)4.48626930
49detection of external biotic stimulus (GO:0098581)4.39241576
50bile acid and bile salt transport (GO:0015721)4.34509537
51detection of bacterium (GO:0016045)4.32606995
52sterol transport (GO:0015918)4.30929245
53cholesterol transport (GO:0030301)4.30929245
54glucose 6-phosphate metabolic process (GO:0051156)4.26128779
55neutrophil activation involved in immune response (GO:0002283)4.18107464
56regulation of cholesterol homeostasis (GO:2000188)4.15331968
57positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.12352711
58digestive system process (GO:0022600)4.12165514
59purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.09969178
603-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.09969178
61lipoprotein transport (GO:0042953)4.07038503
62homocysteine metabolic process (GO:0050667)4.06927351
63cellular extravasation (GO:0045123)4.03636485
64microglial cell activation (GO:0001774)4.00876991
65plasma lipoprotein particle organization (GO:0071827)3.99597205
66triglyceride homeostasis (GO:0070328)3.96190863
67acylglycerol homeostasis (GO:0055090)3.96190863
68fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.95666573
69regulation of B cell receptor signaling pathway (GO:0050855)3.95189409
70cysteine metabolic process (GO:0006534)3.94714666
71alpha-linolenic acid metabolic process (GO:0036109)3.93365524
72positive regulation of fatty acid biosynthetic process (GO:0045723)3.90358594
73modified amino acid transport (GO:0072337)3.89973313
74protein-lipid complex subunit organization (GO:0071825)3.89457659
75erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.88750542
76L-phenylalanine catabolic process (GO:0006559)3.88750542
77exogenous drug catabolic process (GO:0042738)3.88522081
78response to host immune response (GO:0052572)3.86517903
79response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.86517903
80response to peptidoglycan (GO:0032494)3.81016068
81detection of biotic stimulus (GO:0009595)3.79767077
82adhesion of symbiont to host cell (GO:0044650)3.78803887
83virion attachment to host cell (GO:0019062)3.78803887
84erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.78713053
85L-phenylalanine metabolic process (GO:0006558)3.78713053
86positive regulation of lipid catabolic process (GO:0050996)3.77760229
87leukocyte migration involved in inflammatory response (GO:0002523)3.77752095
88leukocyte aggregation (GO:0070486)3.75768039
89drug transmembrane transport (GO:0006855)3.75194319
90regulation of cellular extravasation (GO:0002691)3.70866777
91actin filament depolymerization (GO:0030042)3.70367380
92nucleobase catabolic process (GO:0046113)3.69522780
93phospholipid homeostasis (GO:0055091)3.69499789
94cellular glucuronidation (GO:0052695)3.68287184
95drug transport (GO:0015893)3.67739682
96plasma lipoprotein particle clearance (GO:0034381)3.66882475
97macrophage activation (GO:0042116)3.66816137
98drug metabolic process (GO:0017144)3.62884767
99neutrophil activation (GO:0042119)3.59336864
100regulation of gamma-delta T cell activation (GO:0046643)3.59150141
101aromatic amino acid family catabolic process (GO:0009074)3.59132624
102response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.57167843
103response to host (GO:0075136)3.57167843
104response to host defenses (GO:0052200)3.57167843
105lipid homeostasis (GO:0055088)3.55186427
106positive regulation of triglyceride metabolic process (GO:0090208)3.54730052
107UDP-N-acetylglucosamine metabolic process (GO:0006047)3.51408032
108lysine metabolic process (GO:0006553)3.50855289
109lysine catabolic process (GO:0006554)3.50855289
110immunoglobulin mediated immune response (GO:0016064)3.47497130
111negative regulation of lymphocyte mediated immunity (GO:0002707)3.46872925
112negative regulation of digestive system process (GO:0060457)3.45736792
113bile acid metabolic process (GO:0008206)3.45019256
114negative regulation of interleukin-12 production (GO:0032695)3.44311438
115respiratory burst (GO:0045730)3.41461701
116peptide hormone processing (GO:0016486)3.40644605
117peptide catabolic process (GO:0043171)3.35716635
118epoxygenase P450 pathway (GO:0019373)3.35221894
119transepithelial transport (GO:0070633)3.34915641
120adhesion of symbiont to host (GO:0044406)3.34746038
121tryptophan catabolic process (GO:0006569)3.34541290
122indole-containing compound catabolic process (GO:0042436)3.34541290
123indolalkylamine catabolic process (GO:0046218)3.34541290
124alkaloid metabolic process (GO:0009820)3.33573410
125regulation of gamma-delta T cell differentiation (GO:0045586)3.32580375
126kynurenine metabolic process (GO:0070189)3.31072499
127production of molecular mediator involved in inflammatory response (GO:0002532)3.30625634
128diacylglycerol metabolic process (GO:0046339)3.28381188
129amino-acid betaine metabolic process (GO:0006577)3.27892669
130regulation of guanylate cyclase activity (GO:0031282)3.27580205
131bile acid biosynthetic process (GO:0006699)3.26894483
132glucuronate metabolic process (GO:0019585)3.26154729
133uronic acid metabolic process (GO:0006063)3.26154729
134glyoxylate metabolic process (GO:0046487)3.22997209
135neutrophil mediated immunity (GO:0002446)3.22458087
136granulocyte activation (GO:0036230)3.21821737
137bundle of His cell to Purkinje myocyte communication (GO:0086069)3.20467500
138sulfur amino acid catabolic process (GO:0000098)3.19066924
139regulation of cholesterol transport (GO:0032374)3.18922651
140regulation of sterol transport (GO:0032371)3.18922651
141positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.18166856
142dendritic cell migration (GO:0036336)3.17958028
143disruption of cells of other organism (GO:0044364)3.17482343
144killing of cells of other organism (GO:0031640)3.17482343
145tryptophan metabolic process (GO:0006568)3.16417431
146fructose metabolic process (GO:0006000)3.16413413
147dendritic cell chemotaxis (GO:0002407)3.14182112
148positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.12326358
149response to interleukin-15 (GO:0070672)3.11576361
150heme transport (GO:0015886)3.10895845
151antigen processing and presentation via MHC class Ib (GO:0002475)3.09501608
152fat-soluble vitamin biosynthetic process (GO:0042362)3.08084975
153negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.06902862
154myeloid cell activation involved in immune response (GO:0002275)3.05118170
155maintenance of gastrointestinal epithelium (GO:0030277)3.04900082
156leukotriene metabolic process (GO:0006691)3.02220698
157negative regulation of leukocyte mediated immunity (GO:0002704)3.00073946
158regulation of dendritic cell antigen processing and presentation (GO:0002604)2.96463912
159regulation of mast cell degranulation (GO:0043304)2.93427567
160T-helper 1 type immune response (GO:0042088)2.92610433
161negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.90225830
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.89028883
163positive regulation of Cdc42 GTPase activity (GO:0043089)2.87626783
164negative regulation of toll-like receptor signaling pathway (GO:0034122)2.83530399
165regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.82851880
166regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.82030436
167type I interferon signaling pathway (GO:0060337)2.80215401
168cellular response to type I interferon (GO:0071357)2.80215401
169defense response to fungus (GO:0050832)2.80156872
170regulation of cellular amide metabolic process (GO:0034248)2.79820200
171B cell receptor signaling pathway (GO:0050853)2.79093183
172regulation of myeloid leukocyte mediated immunity (GO:0002886)2.79013495
173response to type I interferon (GO:0034340)2.78491128
174positive regulation of toll-like receptor signaling pathway (GO:0034123)2.77554109
175cellular response to interleukin-15 (GO:0071350)2.77534413
176positive regulation of interferon-alpha production (GO:0032727)2.77322842
177neutrophil chemotaxis (GO:0030593)2.77163076
178myeloid leukocyte mediated immunity (GO:0002444)2.71862118
179interferon-gamma-mediated signaling pathway (GO:0060333)2.71649903
180germinal center formation (GO:0002467)2.71109304
181negative regulation of T cell mediated immunity (GO:0002710)2.70576401
182neutrophil migration (GO:1990266)2.70356358
183regulation of toll-like receptor signaling pathway (GO:0034121)2.69939827
184regulation of leukocyte degranulation (GO:0043300)2.68199249
185regulation of mast cell activation involved in immune response (GO:0033006)2.67211356
186B cell mediated immunity (GO:0019724)2.64512411
187defense response to protozoan (GO:0042832)2.64362071
188intestinal cholesterol absorption (GO:0030299)10.1311450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.17945575
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.92398562
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.49726200
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.13022603
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.12758996
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.89138656
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.72698245
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.99485465
9* CDX2_20551321_ChIP-Seq_CACO-2_Human3.59605017
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.35183078
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.30766097
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.26433483
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.20623394
14HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.05442249
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03672330
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.02673423
17CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.99119460
18IRF8_27001747_Chip-Seq_BMDM_Mouse2.93278355
19STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.91177510
20SOX2_27498859_Chip-Seq_STOMACH_Mouse2.91066595
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.77322462
22MYB_21317192_ChIP-Seq_ERMYB_Mouse2.54363852
23NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53889672
24GATA4_25053715_ChIP-Seq_YYC3_Human2.40965970
25VDR_24763502_ChIP-Seq_THP-1_Human2.24510671
26RUNX_20019798_ChIP-Seq_JUKART_Human2.23629947
27TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.15956712
28SPI1_23547873_ChIP-Seq_NB4_Human2.12829369
29SPI1_23127762_ChIP-Seq_K562_Human2.12265399
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.08145877
31CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.06494587
32SMAD_19615063_ChIP-ChIP_OVARY_Human2.04274126
33VDR_24787735_ChIP-Seq_THP-1_Human2.02667945
34GATA6_25053715_ChIP-Seq_YYC3_Human2.01629050
35GATA1_22025678_ChIP-Seq_K562_Human1.92915938
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.88944383
37VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.86513738
38MYB_26560356_Chip-Seq_TH2_Human1.81972534
39VDR_21846776_ChIP-Seq_THP-1_Human1.81843485
40FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.80823907
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.78322763
42BRD4_27068464_Chip-Seq_AML-cells_Mouse1.76875001
43SOX2_20726797_ChIP-Seq_SW620_Human1.76282252
44RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75027266
45FOXA2_19822575_ChIP-Seq_HepG2_Human1.74453593
46STAT4_19710469_ChIP-ChIP_TH1__Mouse1.71878648
47SCL_19346495_ChIP-Seq_HPC-7_Human1.70440765
48HNF4A_19822575_ChIP-Seq_HepG2_Human1.70124983
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.68888882
50RUNX1_22412390_ChIP-Seq_EML_Mouse1.67077048
51PPAR_26484153_Chip-Seq_NCI-H1993_Human1.63872139
52CLOCK_20551151_ChIP-Seq_293T_Human1.61407486
53MYB_26560356_Chip-Seq_TH1_Human1.60047157
54MAF_26560356_Chip-Seq_TH1_Human1.56540469
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.51268955
56CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.48192867
57SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.47782744
58GATA2_22383799_ChIP-Seq_G1ME_Mouse1.41300417
59* UTX_26944678_Chip-Seq_JUKART_Human1.40598119
60TCF7_22412390_ChIP-Seq_EML_Mouse1.39494755
61BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.35197290
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34400401
63CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.33300168
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.31026181
65GATA3_27048872_Chip-Seq_THYMUS_Human1.28189982
66KDM2B_26808549_Chip-Seq_SUP-B15_Human1.24412593
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.23565687
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.22235913
69PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.20741100
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.20602008
71GATA2_19941826_ChIP-Seq_K562_Human1.20286529
72NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.19366827
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.19118520
74GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18073289
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.16264918
76TCF4_18268006_ChIP-ChIP_LS174T_Human1.15233625
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.15059245
78GATA1_22383799_ChIP-Seq_G1ME_Mouse1.13453970
79ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.13302911
80FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.12641423
81RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.12634754
82GATA3_26560356_Chip-Seq_TH2_Human1.11536661
83SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10373661
84CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07843233
85SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07638404
86PU_27001747_Chip-Seq_BMDM_Mouse1.07504385
87* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07340956
88PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07055564
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.06279870
90KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05013806
91TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04227656
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.03329754
93ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03185631
94LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.03086405
95TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02429617
96FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02263742
97THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01459643
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01377898
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01214821
100KDM2B_26808549_Chip-Seq_DND41_Human1.00427146
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00243298
102CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99376410
103RUNX1_27514584_Chip-Seq_MCF-7_Human0.99227023
104ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98926427
105SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95142030
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94504450
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.94375535
108KLF5_25053715_ChIP-Seq_YYC3_Human0.93181033
109MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92958883
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91026028
111IRF8_22096565_ChIP-ChIP_GC-B_Human0.90867834
112BCL6_27268052_Chip-Seq_Bcells_Human0.90412558
113MAF_26560356_Chip-Seq_TH2_Human0.89732664
114CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.89382212
115IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89109376
116EGR1_19374776_ChIP-ChIP_THP-1_Human0.88934120
117KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.88909286
118RACK7_27058665_Chip-Seq_MCF-7_Human0.87873720
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.87366311
120EGR1_19032775_ChIP-ChIP_M12_Human0.87111835
121VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.86658713
122BCOR_27268052_Chip-Seq_Bcells_Human0.86517675
123KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.86341581
124CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.85639497
125SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85576674
126HTT_18923047_ChIP-ChIP_STHdh_Human0.82774141
127EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.82343400
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.80816458
129ZNF263_19887448_ChIP-Seq_K562_Human0.79781231
130GATA1_19941826_ChIP-Seq_K562_Human0.79578255
131FOXA1_25552417_ChIP-Seq_VCAP_Human0.78934240
132ATF3_27146783_Chip-Seq_COLON_Human0.78543032
133FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.78315937
134SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.77730807
135PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.77304790
136PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76883709
137NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.76649484
138STAT1_17558387_ChIP-Seq_HELA_Human0.75674363
139CREB1_26743006_Chip-Seq_LNCaP_Human0.73073359
140* TP63_23658742_ChIP-Seq_EP156T_Human0.72179054
141FOXM1_26456572_ChIP-Seq_MCF-7_Human0.70785187
142CDX2_22108803_ChIP-Seq_LS180_Human0.70534928
143STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.69595586
144TP53_16413492_ChIP-PET_HCT116_Human0.69383025
145PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69142376
146* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.68430200
147AR_21909140_ChIP-Seq_LNCAP_Human0.66373074
148RARA_24833708_ChIP-Seq_LIVER_Mouse0.65884193
149NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65034622
150GATA3_24758297_ChIP-Seq_MCF-7_Human0.64592373
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.64283903
152GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.64240839
153GATA1_19941827_ChIP-Seq_MEL_Mouse0.64150748
154CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.64103341
155LXR_22292898_ChIP-Seq_THP-1_Human0.63023357
156GATA2_21666600_ChIP-Seq_HMVEC_Human0.62704223
157SMAD3_21741376_ChIP-Seq_HESCs_Human0.62432213
158MYC_19915707_ChIP-ChIP_AK7_Human0.62160372
159KAP1_22055183_ChIP-Seq_ESCs_Mouse0.61755892
160SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.59782127
161JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.59592512
162TCF3_18692474_ChIP-Seq_MEFs_Mouse0.58812298
163CEBPB_22108803_ChIP-Seq_LS180_Human0.57985577
164TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57301881
165HIF1A_21447827_ChIP-Seq_MCF-7_Human0.57030089
166SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.56041880

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.81743052
2MP0002139_abnormal_hepatobiliary_system6.26009050
3MP0001666_abnormal_nutrient_absorption5.38594036
4MP0005085_abnormal_gallbladder_physiolo5.19382686
5MP0003724_increased_susceptibility_to4.76647531
6MP0008875_abnormal_xenobiotic_pharmacok4.42318002
7MP0005365_abnormal_bile_salt4.24898638
8MP0003252_abnormal_bile_duct4.13280225
9MP0009840_abnormal_foam_cell3.89272805
10MP0010329_abnormal_lipoprotein_level3.37457308
11MP0003303_peritoneal_inflammation3.30261832
12MP0003436_decreased_susceptibility_to3.29754233
13MP0001835_abnormal_antigen_presentation3.00922918
14MP0003806_abnormal_nucleotide_metabolis2.60575773
15MP0009785_altered_susceptibility_to2.58224281
16MP0002419_abnormal_innate_immunity2.46543625
17MP0003183_abnormal_peptide_metabolism2.43052793
18MP0010234_abnormal_vibrissa_follicle2.42330816
19MP0004264_abnormal_extraembryonic_tissu2.40405712
20MP0005025_abnormal_response_to2.38378403
21MP0008260_abnormal_autophagy2.37297489
22MP0004019_abnormal_vitamin_homeostasis2.34045986
23MP0001800_abnormal_humoral_immune2.17327737
24MP0005000_abnormal_immune_tolerance2.08453458
25MP0005671_abnormal_response_to2.05639863
26MP0005387_immune_system_phenotype2.03823716
27MP0001790_abnormal_immune_system2.03823716
28MP0000685_abnormal_immune_system2.02887199
29MP0005332_abnormal_amino_acid2.02147189
30MP0006082_CNS_inflammation2.01691112
31MP0000462_abnormal_digestive_system1.99141087
32MP0002723_abnormal_immune_serum1.94739500
33MP0002452_abnormal_antigen_presenting1.84553168
34MP0002420_abnormal_adaptive_immunity1.84237159
35MP0001819_abnormal_immune_cell1.83589040
36MP0003191_abnormal_cellular_cholesterol1.78345031
37MP0002148_abnormal_hypersensitivity_rea1.76496856
38MP0001533_abnormal_skeleton_physiology1.75600173
39MP0009697_abnormal_copulation1.72511519
40MP0005084_abnormal_gallbladder_morpholo1.67979484
41MP0002118_abnormal_lipid_homeostasis1.64373056
42MP0000609_abnormal_liver_physiology1.63136072
43MP0003866_abnormal_defecation1.57608497
44MP0002396_abnormal_hematopoietic_system1.57237983
45MP0003705_abnormal_hypodermis_morpholog1.55518454
46MP0000465_gastrointestinal_hemorrhage1.55032263
47MP0004147_increased_porphyrin_level1.54508992
48MP0005409_darkened_coat_color1.54028922
49MP0002822_catalepsy1.53878727
50MP0003300_gastrointestinal_ulcer1.52968580
51MP0004043_abnormal_pH_regulation1.48533202
52MP0002132_abnormal_respiratory_system1.39523941
53MP0003828_pulmonary_edema1.38986626
54MP0000716_abnormal_immune_system1.36102865
55MP0002254_reproductive_system_inflammat1.35595027
56MP0002277_abnormal_respiratory_mucosa1.34742166
57MP0009643_abnormal_urine_homeostasis1.32159544
58MP0004883_abnormal_blood_vessel1.28815302
59MP0002405_respiratory_system_inflammati1.28503928
60MP0005319_abnormal_enzyme/_coenzyme1.28129906
61MP0003763_abnormal_thymus_physiology1.26567774
62MP0001764_abnormal_homeostasis1.25324954
63MP0002166_altered_tumor_susceptibility1.23861202
64MP0002398_abnormal_bone_marrow1.22983511
65MP0005448_abnormal_energy_balance1.22816117
66MP0003172_abnormal_lysosome_physiology1.19174877
67MP0000858_altered_metastatic_potential1.14403053
68MP0000538_abnormal_urinary_bladder1.12883659
69MP0003868_abnormal_feces_composition1.12536504
70MP0005083_abnormal_biliary_tract1.11023327
71MP0003075_altered_response_to1.10969889
72MP0005381_digestive/alimentary_phenotyp1.10870710
73MP0001663_abnormal_digestive_system1.10744780
74MP0009278_abnormal_bone_marrow1.10712669
75MP0009333_abnormal_splenocyte_physiolog1.08188276
76MP0005164_abnormal_response_to1.06985872
77MP0000015_abnormal_ear_pigmentation1.05494896
78MP0002722_abnormal_immune_system1.05342825
79MP0002429_abnormal_blood_cell1.03957922
80MP0005310_abnormal_salivary_gland1.03589034
81MP0001664_abnormal_digestion1.00835161
82MP0010155_abnormal_intestine_physiology1.00638905
83MP0002998_abnormal_bone_remodeling1.00202682
84MP0000689_abnormal_spleen_morphology0.99304405
85MP0005451_abnormal_body_composition0.98094623
86MP0008004_abnormal_stomach_pH0.97610590
87MP0009780_abnormal_chondrocyte_physiolo0.97263435
88MP0009053_abnormal_anal_canal0.97023790
89MP0010352_gastrointestinal_tract_polyps0.95901844
90MP0000477_abnormal_intestine_morphology0.95359920
91MP0002796_impaired_skin_barrier0.92671423
92MP0003448_altered_tumor_morphology0.91505168
93MP0001545_abnormal_hematopoietic_system0.89759776
94MP0005397_hematopoietic_system_phenotyp0.89759776
95MP0001873_stomach_inflammation0.88803270
96MP0005636_abnormal_mineral_homeostasis0.88044675
97MP0002089_abnormal_postnatal_growth/wei0.86637709
98* MP0005584_abnormal_enzyme/coenzyme_acti0.86141352
99MP0004381_abnormal_hair_follicle0.85492517
100MP0003195_calcinosis0.85046901
101MP0004484_altered_response_of0.84340651
102MP0005535_abnormal_body_temperature0.84333790
103MP0005174_abnormal_tail_pigmentation0.82451871
104MP0002138_abnormal_hepatobiliary_system0.81634761
105MP0000249_abnormal_blood_vessel0.81310231
106MP0003878_abnormal_ear_physiology0.79899604
107MP0005377_hearing/vestibular/ear_phenot0.79899604
108MP0002006_tumorigenesis0.79877506
109MP0000604_amyloidosis0.79848477
110MP0000569_abnormal_digit_pigmentation0.79119398
111MP0000537_abnormal_urethra_morphology0.78701006
112MP0009384_cardiac_valve_regurgitation0.78542415
113MP0009765_abnormal_xenobiotic_induced0.77920325
114MP0000598_abnormal_liver_morphology0.73740657
115MP0003656_abnormal_erythrocyte_physiolo0.73490487
116MP0001851_eye_inflammation0.72651065
117MP0003690_abnormal_glial_cell0.72304489
118MP0004858_abnormal_nervous_system0.71996208
119* MP0009642_abnormal_blood_homeostasis0.71848978
120MP0009379_abnormal_foot_pigmentation0.70092939
121MP0005167_abnormal_blood-brain_barrier0.68368985
122MP0009764_decreased_sensitivity_to0.67179337
123MP0002136_abnormal_kidney_physiology0.66981823
124MP0004947_skin_inflammation0.65312165
125MP0008872_abnormal_physiological_respon0.65031614
126MP0002876_abnormal_thyroid_physiology0.64066298
127MP0006054_spinal_hemorrhage0.61984816
128MP0001765_abnormal_ion_homeostasis0.60338454
129MP0003718_maternal_effect0.58718923
130MP0008469_abnormal_protein_level0.58462159
131MP0005166_decreased_susceptibility_to0.58430949
132MP0000467_abnormal_esophagus_morphology0.55157125
133* MP0005376_homeostasis/metabolism_phenot0.54654222
134MP0002971_abnormal_brown_adipose0.54115516
135MP0003638_abnormal_response/metabolism_0.52659570
136MP0001756_abnormal_urination0.52320381
137MP0009763_increased_sensitivity_to0.50626640
138MP0000490_abnormal_crypts_of0.50220755
139MP0005408_hypopigmentation0.50065543
140* MP0002078_abnormal_glucose_homeostasis0.49819527
141MP0010678_abnormal_skin_adnexa0.48427522
142MP0005464_abnormal_platelet_physiology0.48130444
143MP0005334_abnormal_fat_pad0.48062926
144MP0003453_abnormal_keratinocyte_physiol0.46655867
145MP0008873_increased_physiological_sensi0.45894199
146MP0005501_abnormal_skin_physiology0.45401328
147MP0009115_abnormal_fat_cell0.45102142
148MP0002098_abnormal_vibrissa_morphology0.44960466
149MP0000427_abnormal_hair_cycle0.44531083
150* MP0005266_abnormal_metabolism0.43276910
151MP0001881_abnormal_mammary_gland0.39943933
152MP0000230_abnormal_systemic_arterial0.39814682
153MP0001849_ear_inflammation0.39343232
154MP0000579_abnormal_nail_morphology0.38831210
155MP0001216_abnormal_epidermal_layer0.34213506
156MP0001845_abnormal_inflammatory_respons0.33242455
157MP0005023_abnormal_wound_healing0.31982863
158MP0001191_abnormal_skin_condition0.31920215
159MP0004270_analgesia0.30461195

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)8.29584797
2Abnormality of glutamine family amino acid metabolism (HP:0010902)6.84484449
3Ileus (HP:0002595)6.77032075
4Acanthocytosis (HP:0001927)6.60391633
5Eczematoid dermatitis (HP:0000976)6.47254211
6Conjugated hyperbilirubinemia (HP:0002908)5.89782562
7Intrahepatic cholestasis (HP:0001406)5.61805666
8Xanthomatosis (HP:0000991)5.28549538
9Abnormality of monocarboxylic acid metabolism (HP:0010996)5.20523765
10Hypolipoproteinemia (HP:0010981)5.18902635
11Fat malabsorption (HP:0002630)5.08031433
12Recurrent bacterial skin infections (HP:0005406)5.06774209
13Recurrent abscess formation (HP:0002722)5.06688771
14Orchitis (HP:0100796)5.04636401
15Myositis (HP:0100614)4.95251425
16Malnutrition (HP:0004395)4.92546392
17Hydroxyprolinuria (HP:0003080)4.60344657
18Abnormality of proline metabolism (HP:0010907)4.60344657
19Retrobulbar optic neuritis (HP:0100654)4.55201921
20Optic neuritis (HP:0100653)4.55201921
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.35915067
22Abnormality of macrophages (HP:0004311)4.35683738
23Hyperglycinuria (HP:0003108)4.25274963
24Epidermoid cyst (HP:0200040)4.19302768
25Gingivitis (HP:0000230)4.17894609
26Poikilocytosis (HP:0004447)4.09467445
27Autoimmune thrombocytopenia (HP:0001973)4.06212434
28Recurrent gram-negative bacterial infections (HP:0005420)4.05968437
29Hypercholesterolemia (HP:0003124)3.95562344
30Gastrointestinal infarctions (HP:0005244)3.94796953
31Deep venous thrombosis (HP:0002625)3.77164739
32Abnormality of aromatic amino acid family metabolism (HP:0004338)3.71633181
33Elevated erythrocyte sedimentation rate (HP:0003565)3.71256099
34Abnormality of aspartate family amino acid metabolism (HP:0010899)3.59208215
35Pigmentary retinal degeneration (HP:0001146)3.58750574
36Encephalitis (HP:0002383)3.57641119
37Stomatitis (HP:0010280)3.55616879
38Abnormality of serine family amino acid metabolism (HP:0010894)3.53440506
39Abnormality of glycine metabolism (HP:0010895)3.53440506
40Recurrent fungal infections (HP:0002841)3.52079253
41Abnormality of sulfur amino acid metabolism (HP:0004339)3.49043077
42Hyperammonemia (HP:0001987)3.48673648
43Abnormal delayed hypersensitivity skin test (HP:0002963)3.48671104
44Keratoconjunctivitis sicca (HP:0001097)3.46476537
45Right ventricular cardiomyopathy (HP:0011663)3.35732539
46Chronic obstructive pulmonary disease (HP:0006510)3.29313143
47Obstructive lung disease (HP:0006536)3.29313143
48Meningitis (HP:0001287)3.28868519
49Mediastinal lymphadenopathy (HP:0100721)3.24473877
50Recurrent skin infections (HP:0001581)3.24154178
51Prolonged partial thromboplastin time (HP:0003645)3.23160705
52Abnormality of purine metabolism (HP:0004352)3.22056625
53Keratoconjunctivitis (HP:0001096)3.16906465
54Vasculitis (HP:0002633)3.15466842
55Abnormality of urine glucose concentration (HP:0011016)3.15375730
56Glycosuria (HP:0003076)3.15375730
57Peritonitis (HP:0002586)3.14097152
58Widely patent fontanelles and sutures (HP:0004492)3.10223938
59Spontaneous hematomas (HP:0007420)3.10053339
60Autoimmune hemolytic anemia (HP:0001890)3.05590466
61Hyperbilirubinemia (HP:0002904)3.02383370
62Abnormality of nucleobase metabolism (HP:0010932)3.02045427
63Chronic diarrhea (HP:0002028)2.96993148
64Urticaria (HP:0001025)2.91707513
65Cupped ribs (HP:0000887)2.90356802
66Metabolic acidosis (HP:0001942)2.89656765
67Hypoglycemic coma (HP:0001325)2.89576054
68Facial shape deformation (HP:0011334)2.85588221
69Potter facies (HP:0002009)2.85588221
70Hemoptysis (HP:0002105)2.85459806
71Chest pain (HP:0100749)2.81562773
72Abdominal distention (HP:0003270)2.79933168
73Pulmonary infiltrates (HP:0002113)2.79539529
74Increased mean platelet volume (HP:0011877)2.78988863
75Hypoalphalipoproteinemia (HP:0003233)2.76254739
76Abnormality of the common coagulation pathway (HP:0010990)2.75708471
77Chronic mucocutaneous candidiasis (HP:0002728)2.72646962
78Recurrent cutaneous fungal infections (HP:0011370)2.72646962
79Gingival bleeding (HP:0000225)2.66740820
80Cellulitis (HP:0100658)2.66382230
81Abnormality of T cell number (HP:0011839)2.66251127
82Reticulocytosis (HP:0001923)2.63500286
83Abnormality of pyrimidine metabolism (HP:0004353)2.62023032
84Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.62007135
85T lymphocytopenia (HP:0005403)2.60924029
86Complement deficiency (HP:0004431)2.58741625
87Hyperlipoproteinemia (HP:0010980)2.55889956
88Nephrolithiasis (HP:0000787)2.53406447
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52942305
90Ketosis (HP:0001946)2.52776230
91Gastrointestinal dysmotility (HP:0002579)2.50721253
92Anorexia (HP:0002039)2.50025969
93Arterial thrombosis (HP:0004420)2.48728961
94Skin nodule (HP:0200036)2.47385498
95Abnormal platelet volume (HP:0011876)2.46068660
96Abnormality of vitamin metabolism (HP:0100508)2.45996922
97Dehydration (HP:0001944)2.41536747
98Leukocytosis (HP:0001974)2.38924662
99Inflammation of the large intestine (HP:0002037)2.35826416
100Episodic fever (HP:0001954)2.34771321
101Abnormal glucose tolerance (HP:0001952)2.34584684
102Prolonged bleeding time (HP:0003010)2.33214015
103Pustule (HP:0200039)2.32720117
104Osteomyelitis (HP:0002754)2.32066449
105Pulmonary embolism (HP:0002204)2.29547333
106Abnormality of fatty-acid metabolism (HP:0004359)2.29511223
107Abnormality of T cells (HP:0002843)2.29498689
108Mesangial abnormality (HP:0001966)2.28940272
109Segmental peripheral demyelination/remyelination (HP:0003481)2.26871312
110Petechiae (HP:0000967)2.24115516
111Abnormality of the vitamin B12 metabolism (HP:0004341)2.23348570
112Ketoacidosis (HP:0001993)2.22545220
113Gastrointestinal inflammation (HP:0004386)2.21469408
114Thin bony cortex (HP:0002753)2.20627324
115Confusion (HP:0001289)2.19740925
116Polycythemia (HP:0001901)2.19597659
117Abnormality of the pleura (HP:0002103)2.16723276
118Abnormality of vitamin B metabolism (HP:0004340)2.16462131
119Abnormality of the peritoneum (HP:0002585)2.15016516
120Hyperglycinemia (HP:0002154)2.14436831
121Sensorimotor neuropathy (HP:0007141)2.13294138
122Gangrene (HP:0100758)2.13263415
123Cholecystitis (HP:0001082)2.12820538
124Abnormal gallbladder physiology (HP:0012438)2.12820538
125Epistaxis (HP:0000421)2.11340260
126Symptomatic seizures (HP:0011145)2.10588028
127Abnormality of the intrinsic pathway (HP:0010989)2.10425592
128Paresthesia (HP:0003401)2.09227710
129Abnormality of T cell physiology (HP:0011840)2.08960996
130Steatorrhea (HP:0002570)2.07904925
131Skin rash (HP:0000988)2.07799319
132Pancreatitis (HP:0001733)2.07221310
133Hyperphosphaturia (HP:0003109)2.06014499
134Hypochromic anemia (HP:0001931)2.04923173
135Recurrent viral infections (HP:0004429)2.04620496
136Proximal tubulopathy (HP:0000114)2.03916444
137Joint hemorrhage (HP:0005261)2.02965674
138Granulocytopenia (HP:0001913)2.02601981
139Hypochromic microcytic anemia (HP:0004840)2.02437905
140Nausea (HP:0002018)2.00832715
141Premature loss of primary teeth (HP:0006323)1.99665967
142Neoplasm of the tracheobronchial system (HP:0100552)1.98602560
143Increased IgE level (HP:0003212)1.98363107
144Late onset (HP:0003584)1.94936242
145Hypoglycemic seizures (HP:0002173)1.94577655
146Rectal prolapse (HP:0002035)1.94097296
147Alveolar cell carcinoma (HP:0006519)1.94083220
148Cholelithiasis (HP:0001081)1.93922570
149Abnormal gallbladder morphology (HP:0012437)1.93625903
150Hypophosphatemia (HP:0002148)1.92787825
151Vascular calcification (HP:0004934)1.91770831
152Cheilitis (HP:0100825)1.90935948
153Sepsis (HP:0100806)1.90542483
154Increased IgM level (HP:0003496)1.90273496
155Colitis (HP:0002583)1.88877546
156Amyloidosis (HP:0011034)1.88365055
157Acne (HP:0001061)1.87962261
158Abnormality of complement system (HP:0005339)1.87605825
159Subacute progressive viral hepatitis (HP:0006572)1.87056738
160Recurrent pneumonia (HP:0006532)1.86042893
161Hepatocellular carcinoma (HP:0001402)1.84821546
162Abnormal biliary tract morphology (HP:0012440)1.84193214
163Abnormality of transition element cation homeostasis (HP:0011030)1.83898674
164Glomerulopathy (HP:0100820)1.83847998
165Myocardial infarction (HP:0001658)1.82982141
166Eosinophilia (HP:0001880)1.82882989
167Megaloblastic anemia (HP:0001889)1.82848044
168Systemic lupus erythematosus (HP:0002725)1.82795808
169Wide cranial sutures (HP:0010537)1.82638561
170Abnormality of methionine metabolism (HP:0010901)1.82326117
171Abnormal platelet function (HP:0011869)1.81610417
172Impaired platelet aggregation (HP:0003540)1.81610417
173Abnormality of the endocardium (HP:0004306)1.79656608
174Esophageal varix (HP:0002040)1.79272416
175Hemorrhage of the eye (HP:0011885)1.78581469
176Irritability (HP:0000737)1.76550388
177Hypoproteinemia (HP:0003075)1.75234098
178Skin ulcer (HP:0200042)1.75135186
179Lymphopenia (HP:0001888)1.72514301

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK7.19884011
2LMTK26.04292816
3MST44.09574419
4MST1R4.04459300
5ACVR1B3.31117105
6PRKG23.21641547
7GRK63.08566688
8IRAK42.97832019
9AKT32.92541337
10BLK2.83576869
11MAP2K32.74838155
12ERN12.66086485
13MAP3K102.61337700
14RIPK12.40495789
15PTK62.15935147
16NME12.13356814
17TAOK32.06389017
18NUAK11.90901388
19PRPF4B1.88242334
20ZAP701.74435126
21MAP3K21.72984922
22FES1.70869828
23EPHA21.70184864
24JAK31.67710228
25LATS11.60843015
26FGR1.57787481
27BTK1.56866723
28IRAK11.55968803
29YES11.48498694
30FGFR41.45573771
31MET1.43809523
32IKBKE1.42181050
33SYK1.40329841
34MAP2K21.39957636
35HCK1.36413113
36INSRR1.35986175
37TXK1.35906189
38MAP3K61.34664549
39EPHA31.32802739
40BCKDK1.26416391
41MAP3K71.21169435
42EPHB21.20258890
43LYN1.18566387
44TNK21.17016795
45BMPR21.13104646
46PRKAA21.11346167
47MAPK111.11185857
48IRAK21.10551705
49EPHB11.08824289
50ERBB41.07139650
51STK101.06482730
52ERBB21.05496994
53SIK11.00638996
54TEC0.96506458
55MAP3K50.95071531
56LCK0.89264105
57TESK20.88499338
58CSF1R0.86677456
59PTK20.84377810
60PIK3CA0.83969243
61BMX0.82921666
62NLK0.82634937
63TBK10.81980168
64TYK20.80597395
65PKN20.80495146
66TAOK10.80373629
67MAP2K60.75718489
68KIT0.72805782
69TGFBR20.72702817
70TESK10.72556065
71STK240.72256911
72PIM10.71436856
73FYN0.69152740
74RET0.68995674
75PRKAA10.68641285
76MATK0.67747884
77MAP3K80.67505064
78MAP3K110.63045981
79MAP3K130.62044436
80CDC42BPA0.61900087
81MARK20.60214334
82SCYL20.59687469
83DDR20.59472801
84MYLK0.59208746
85PBK0.58248494
86PDPK10.57775602
87PTK2B0.57220188
88ICK0.56704149
89CDK190.56562166
90MARK30.55399519
91WNK10.54857889
92SIK30.54356859
93TAOK20.53859976
94TTK0.53200946
95PRKCI0.52445882
96MAP2K40.52130025
97KSR10.51945966
98DAPK20.51007499
99CSK0.50935758
100DYRK1B0.49841749
101MAP3K30.49526884
102FER0.48844193
103PRKD20.48152130
104KSR20.46670485
105PDK20.45824576
106IKBKB0.45570397
107STK30.45116641
108GRK10.44291070
109CDK60.43681348
110SGK20.42806858
111PRKACG0.42615389
112MAP3K10.40458782
113RAF10.39975130
114JAK20.39924840
115PDK10.39484245
116MAPKAPK20.39460408
117OXSR10.38097193
118IRAK30.38050109
119STK390.37626510
120MAP3K120.36861028
121PIK3CG0.36248398
122PAK30.35579993
123MAP2K10.35452183
124MAPK40.34764167
125SGK30.34650860
126PRKCD0.34623850
127RPS6KC10.34160962
128RPS6KL10.34160962
129MAPK70.34112664
130PDK40.33859797
131PDK30.33859797
132CAMK1D0.33234314
133CDK120.33198540
134GSK3A0.32874048
135RIPK40.32074672
136PAK40.31884318
137HIPK20.31268249
138FGFR30.30895216
139PRKCQ0.30726302
140FGFR20.30685189
141ITK0.30200684
142PRKCZ0.30055938
143PRKCA0.29817507
144JAK10.28492646
145FLT30.28087916
146LRRK20.24980542
147MAP4K10.23833870
148MAP3K140.21401581
149PDGFRA0.21254846
150AKT20.20612895
151SRC0.20259518
152TRIB30.19050725
153ROCK10.18555989
154STK110.18509735
155KDR0.18216640

Predicted pathways (KEGG)

RankGene SetZ-score
1Fat digestion and absorption_Homo sapiens_hsa049754.35762604
2Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.66579950
3Caffeine metabolism_Homo sapiens_hsa002323.16711941
4Nitrogen metabolism_Homo sapiens_hsa009103.13990014
5Renin-angiotensin system_Homo sapiens_hsa046143.11496663
6Vitamin digestion and absorption_Homo sapiens_hsa049773.02690985
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.89702539
8Mineral absorption_Homo sapiens_hsa049782.62122506
9Leishmaniasis_Homo sapiens_hsa051402.58575390
10Arginine biosynthesis_Homo sapiens_hsa002202.48726028
11Primary bile acid biosynthesis_Homo sapiens_hsa001202.40105975
12Bile secretion_Homo sapiens_hsa049762.31617604
13Sulfur metabolism_Homo sapiens_hsa009202.24189881
14Tryptophan metabolism_Homo sapiens_hsa003802.20307086
15Folate biosynthesis_Homo sapiens_hsa007902.15513340
16* Starch and sucrose metabolism_Homo sapiens_hsa005002.12199108
17Osteoclast differentiation_Homo sapiens_hsa043802.09666040
18Histidine metabolism_Homo sapiens_hsa003402.06878860
19Maturity onset diabetes of the young_Homo sapiens_hsa049502.04204344
20Fatty acid degradation_Homo sapiens_hsa000711.95522279
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85996499
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81597299
23PPAR signaling pathway_Homo sapiens_hsa033201.77910594
24Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.74542582
25Tuberculosis_Homo sapiens_hsa051521.69879572
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68572236
27Graft-versus-host disease_Homo sapiens_hsa053321.61373893
28Allograft rejection_Homo sapiens_hsa053301.59132182
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.57391728
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.54450571
31* Carbohydrate digestion and absorption_Homo sapiens_hsa049731.54326259
32B cell receptor signaling pathway_Homo sapiens_hsa046621.52446654
33Toll-like receptor signaling pathway_Homo sapiens_hsa046201.50311877
34* Galactose metabolism_Homo sapiens_hsa000521.49917051
35Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47253153
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.47035949
37Autoimmune thyroid disease_Homo sapiens_hsa053201.45882858
38Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42515334
39Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42005724
40ABC transporters_Homo sapiens_hsa020101.41409195
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.41393835
42Drug metabolism - other enzymes_Homo sapiens_hsa009831.40016639
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.39477451
44Protein digestion and absorption_Homo sapiens_hsa049741.37852065
45Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.37382315
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36702350
47Fructose and mannose metabolism_Homo sapiens_hsa000511.34975078
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.34637565
49Butanoate metabolism_Homo sapiens_hsa006501.33158742
50Peroxisome_Homo sapiens_hsa041461.32747448
51Chemical carcinogenesis_Homo sapiens_hsa052041.31985178
52Chemokine signaling pathway_Homo sapiens_hsa040621.29586888
53Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28551232
54beta-Alanine metabolism_Homo sapiens_hsa004101.28314811
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25264889
56Hematopoietic cell lineage_Homo sapiens_hsa046401.22072338
57Retinol metabolism_Homo sapiens_hsa008301.19186732
58Glutathione metabolism_Homo sapiens_hsa004801.17006684
59Toxoplasmosis_Homo sapiens_hsa051451.16761682
60Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16524052
61Fatty acid metabolism_Homo sapiens_hsa012121.16192712
62Legionellosis_Homo sapiens_hsa051341.14446563
63Pyruvate metabolism_Homo sapiens_hsa006201.14058087
64Selenocompound metabolism_Homo sapiens_hsa004501.13737233
65Malaria_Homo sapiens_hsa051441.13487505
66Steroid hormone biosynthesis_Homo sapiens_hsa001401.13436829
67Complement and coagulation cascades_Homo sapiens_hsa046101.13024453
68Glycerolipid metabolism_Homo sapiens_hsa005611.12321048
69Influenza A_Homo sapiens_hsa051641.10937104
70NF-kappa B signaling pathway_Homo sapiens_hsa040641.10795829
71Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10643264
72Type I diabetes mellitus_Homo sapiens_hsa049401.09363509
73Asthma_Homo sapiens_hsa053101.06223699
74Measles_Homo sapiens_hsa051621.04276443
75Arginine and proline metabolism_Homo sapiens_hsa003301.04098780
76Carbon metabolism_Homo sapiens_hsa012001.01987020
77TNF signaling pathway_Homo sapiens_hsa046681.01643092
78Propanoate metabolism_Homo sapiens_hsa006400.99265984
79Acute myeloid leukemia_Homo sapiens_hsa052210.98753546
80Antigen processing and presentation_Homo sapiens_hsa046120.97671013
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.95739992
82T cell receptor signaling pathway_Homo sapiens_hsa046600.91215553
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90384749
84Primary immunodeficiency_Homo sapiens_hsa053400.88311193
85Jak-STAT signaling pathway_Homo sapiens_hsa046300.88215008
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87790258
87Pertussis_Homo sapiens_hsa051330.85896516
88Phagosome_Homo sapiens_hsa041450.85024447
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84661040
90Biosynthesis of amino acids_Homo sapiens_hsa012300.83415381
91Phenylalanine metabolism_Homo sapiens_hsa003600.82510467
92Steroid biosynthesis_Homo sapiens_hsa001000.82096363
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77958196
94Hepatitis B_Homo sapiens_hsa051610.76979658
95Non-small cell lung cancer_Homo sapiens_hsa052230.75013111
96Viral myocarditis_Homo sapiens_hsa054160.74693557
97Salmonella infection_Homo sapiens_hsa051320.73319592
98Pentose phosphate pathway_Homo sapiens_hsa000300.71915025
99Lysine degradation_Homo sapiens_hsa003100.71545386
100Platelet activation_Homo sapiens_hsa046110.71271970
101Herpes simplex infection_Homo sapiens_hsa051680.70687517
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69435376
103Prolactin signaling pathway_Homo sapiens_hsa049170.68819946
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62503314
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.62476577
106Apoptosis_Homo sapiens_hsa042100.60493079
107Other glycan degradation_Homo sapiens_hsa005110.60364376
108Tyrosine metabolism_Homo sapiens_hsa003500.60221147
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57597883
110GnRH signaling pathway_Homo sapiens_hsa049120.56941530
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56059665
112Staphylococcus aureus infection_Homo sapiens_hsa051500.55682611
113Pancreatic cancer_Homo sapiens_hsa052120.55455424
114Dorso-ventral axis formation_Homo sapiens_hsa043200.55426095
115Fatty acid elongation_Homo sapiens_hsa000620.55169535
116Amoebiasis_Homo sapiens_hsa051460.54954767
117FoxO signaling pathway_Homo sapiens_hsa040680.54766995
118Sphingolipid metabolism_Homo sapiens_hsa006000.54346963
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53639894
120Fatty acid biosynthesis_Homo sapiens_hsa000610.50202040
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.47943465
122Cysteine and methionine metabolism_Homo sapiens_hsa002700.47368639
123VEGF signaling pathway_Homo sapiens_hsa043700.46943419
124Chronic myeloid leukemia_Homo sapiens_hsa052200.46682762
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.46178134
126Shigellosis_Homo sapiens_hsa051310.44567839
127Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.44065971
128AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.43383180
129Renal cell carcinoma_Homo sapiens_hsa052110.42853810
130Glycerophospholipid metabolism_Homo sapiens_hsa005640.41531515
131Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41104588
132Inositol phosphate metabolism_Homo sapiens_hsa005620.40465224
133* Metabolic pathways_Homo sapiens_hsa011000.36417765
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27929008
135Thyroid hormone synthesis_Homo sapiens_hsa049180.24315044
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.23463146
137Insulin resistance_Homo sapiens_hsa049310.23272083
138Type II diabetes mellitus_Homo sapiens_hsa049300.22834318
139Sulfur relay system_Homo sapiens_hsa041220.22785436
140Linoleic acid metabolism_Homo sapiens_hsa005910.08005254
141African trypanosomiasis_Homo sapiens_hsa051430.07138796
142Pancreatic secretion_Homo sapiens_hsa049720.06741683
143Tight junction_Homo sapiens_hsa045300.06131169
144Adipocytokine signaling pathway_Homo sapiens_hsa049200.05526084
145Hepatitis C_Homo sapiens_hsa051600.03546549
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.02838152
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.01262323
148Ether lipid metabolism_Homo sapiens_hsa00565-0.1368002
149Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0973907
150Glucagon signaling pathway_Homo sapiens_hsa04922-0.0970786
151Gastric acid secretion_Homo sapiens_hsa04971-0.0767154
152Adherens junction_Homo sapiens_hsa04520-0.0735698
153Vitamin B6 metabolism_Homo sapiens_hsa00750-0.0571363
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961-0.0509324
155Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0299733
156Bladder cancer_Homo sapiens_hsa05219-0.0291230
157AMPK signaling pathway_Homo sapiens_hsa04152-0.0224788
158Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960-0.0132076

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