ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	angiotensin maturation (GO:0002003)	7.55475838
2	regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)	5.92625581
3	lipoprotein transport (GO:0042953)	5.12319956
4	regulation of bile acid biosynthetic process (GO:0070857)	5.00131656
5	regulation of cellular extravasation (GO:0002691)	4.77367454
6	maintenance of gastrointestinal epithelium (GO:0030277)	4.72190069
7	regulation of guanylate cyclase activity (GO:0031282)	4.69350362
8	intestinal absorption (GO:0050892)	4.54570305
9	antigen processing and presentation of endogenous peptide antigen (GO:0002483)	4.30037554
10	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.20614848
11	epoxygenase P450 pathway (GO:0019373)	4.17373802
12	antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)	4.15037961
13	antigen processing and presentation of endogenous antigen (GO:0019883)	3.92202094
14	diacylglycerol metabolic process (GO:0046339)	3.89418582
15	regulation of systemic arterial blood pressure by hormone (GO:0001990)	3.87850954
16	regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)	3.87850954
17	endocrine process (GO:0050886)	3.87850954
18	hormone catabolic process (GO:0042447)	3.79063616
19	modulation by symbiont of host immune response (GO:0052553)	3.73006510
20	positive regulation by symbiont of host defense response (GO:0052509)	3.73006510
21	modulation by symbiont of host defense response (GO:0052031)	3.73006510
22	modulation by organism of immune response of other organism involved in symbiotic interaction (GO:00	3.73006510
23	modulation by organism of defense response of other organism involved in symbiotic interaction (GO:0	3.73006510
24	positive regulation by organism of defense response of other organism involved in symbiotic interact	3.73006510
25	positive regulation of guanylate cyclase activity (GO:0031284)	3.68541224
26	fat-soluble vitamin biosynthetic process (GO:0042362)	3.61835901
27	epithelial structure maintenance (GO:0010669)	3.43312400
28	cellular glucuronidation (GO:0052695)	3.42994001
29	peptide hormone processing (GO:0016486)	3.42928669
30	peptide catabolic process (GO:0043171)	3.41958450
31	regulation of systemic arterial blood pressure (GO:0003073)	3.38861281
32	macrophage activation involved in immune response (GO:0002281)	3.32557821
33	regulation of interferon-beta biosynthetic process (GO:0045357)	3.31864363
34	regulation of triglyceride catabolic process (GO:0010896)	3.31619585
35	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.31398446
36	alkaloid metabolic process (GO:0009820)	3.23167603
37	bile acid and bile salt transport (GO:0015721)	3.22483494
38	glucuronate metabolic process (GO:0019585)	3.21638815
39	uronic acid metabolic process (GO:0006063)	3.21638815
40	flavonoid metabolic process (GO:0009812)	3.16200502
41	digestion (GO:0007586)	3.13160478
42	regulation of vitamin metabolic process (GO:0030656)	3.08765741
43	virion attachment to host cell (GO:0019062)	3.08580354
44	adhesion of symbiont to host cell (GO:0044650)	3.08580354
45	detection of molecule of bacterial origin (GO:0032490)	3.07205351
46	detection of other organism (GO:0098543)	3.01208775
47	negative regulation of leukocyte mediated cytotoxicity (GO:0001911)	2.99924424
48	negative regulation of cell killing (GO:0031342)	2.99924424
49	cGMP-mediated signaling (GO:0019934)	2.98579777
50	drug metabolic process (GO:0017144)	2.97649251
51	citrulline biosynthetic process (GO:0019240)	2.92427719
52	digestive system process (GO:0022600)	2.90354791
53	fructose metabolic process (GO:0006000)	2.88727151
54	regulation of cGMP biosynthetic process (GO:0030826)	2.86110934
55	positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)	2.84303337
56	O-glycan processing (GO:0016266)	2.84052144
57	urea cycle (GO:0000050)	2.83965701
58	glycolipid catabolic process (GO:0019377)	2.81991792
59	glycosphingolipid catabolic process (GO:0046479)	2.81592234
60	antimicrobial humoral response (GO:0019730)	2.80314737
61	antibacterial humoral response (GO:0019731)	2.80237120
62	detection of external biotic stimulus (GO:0098581)	2.79437981
63	NADH metabolic process (GO:0006734)	2.79078405
64	dendritic cell chemotaxis (GO:0002407)	2.75659074
65	microglial cell activation (GO:0001774)	2.75255601
66	bundle of His cell to Purkinje myocyte communication (GO:0086069)	2.74314328
67	leukotriene metabolic process (GO:0006691)	2.72150912
68	urea metabolic process (GO:0019627)	2.71014873
69	detection of bacterium (GO:0016045)	2.67943409
70	positive regulation of gamma-delta T cell activation (GO:0046645)	2.65204213
71	dendritic cell migration (GO:0036336)	2.62575870
72	thrombin receptor signaling pathway (GO:0070493)	2.60910047
73	histone H3-K36 demethylation (GO:0070544)	2.60320371
74	positive regulation of toll-like receptor signaling pathway (GO:0034123)	2.59116951
75	vitamin A metabolic process (GO:0006776)	2.58037189
76	positive regulation of Cdc42 GTPase activity (GO:0043089)	2.57136971
77	glycosylceramide metabolic process (GO:0006677)	2.56612053
78	response to host immune response (GO:0052572)	2.56172626
79	response to immune response of other organism involved in symbiotic interaction (GO:0052564)	2.56172626
80	sexual reproduction (GO:0019953)	2.54475082
81	sulfate transmembrane transport (GO:1902358)	2.52812783
82	drug transport (GO:0015893)	2.52668415
83	regulation of gamma-delta T cell activation (GO:0046643)	2.51369962
84	regulation of cholesterol homeostasis (GO:2000188)	2.51180409
85	macrophage activation (GO:0042116)	2.50164857
86	renal system process involved in regulation of blood volume (GO:0001977)	2.49617356
87	immunoglobulin mediated immune response (GO:0016064)	2.49123016
88	negative regulation of toll-like receptor signaling pathway (GO:0034122)	2.48477636
89	cellular extravasation (GO:0045123)	2.47758734
90	mRNA modification (GO:0016556)	2.46831895
91	receptor recycling (GO:0001881)	2.46256739
92	adhesion of symbiont to host (GO:0044406)	2.46198334
93	cytidine metabolic process (GO:0046087)	2.45832466
94	cytidine catabolic process (GO:0006216)	2.45832466
95	cytidine deamination (GO:0009972)	2.45832466
96	regulation of gamma-delta T cell differentiation (GO:0045586)	2.45073777
97	regulation of toll-like receptor signaling pathway (GO:0034121)	2.44275005
98	arginine metabolic process (GO:0006525)	2.42322503
99	lipoprotein metabolic process (GO:0042157)	2.41839949
100	very-low-density lipoprotein particle assembly (GO:0034379)	2.41821321

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	4.35678363
2	IRF8_22096565_ChIP-ChIP_GC-B_Human	3.62539362
3	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	3.60774562
4	CDX2_20551321_ChIP-Seq_CACO-2_Human	2.66732425
5	IRF8_21731497_ChIP-ChIP_J774_Mouse	2.46739419
6	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.34637176
7	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.17438457
8	GATA1_22025678_ChIP-Seq_K562_Human	2.14756407
9	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.96537187
10	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.86651861
11	GATA4_25053715_ChIP-Seq_YYC3_Human	1.86380790
12	SOX2_27498859_Chip-Seq_STOMACH_Mouse	1.77690109
13	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	1.75858864
14	LXR_22158963_ChIP-Seq_LIVER_Mouse	1.71353703
15	STAT3_20064451_ChIP-Seq_CD4+T_Mouse	1.68974954
16	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.68270147
17	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.67300933
18	RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human	1.64473393
19	IRF8_27001747_Chip-Seq_BMDM_Mouse	1.63798575
20	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.63049912
21	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.60792726
22	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	1.60532068
23	FOXO3_23340844_ChIP-Seq_DLD1_Human	1.60373179
24	SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.54308765
25	VDR_24787735_ChIP-Seq_THP-1_Human	1.53354918
26	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	1.51325020
27	STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse	1.46291452
28	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.44747832
29	STAT6_20620947_ChIP-Seq_CD4_POS_T_Human	1.42443033
30	GATA6_25053715_ChIP-Seq_YYC3_Human	1.42184158
31	SOX2_20726797_ChIP-Seq_SW620_Human	1.41763138
32	ESR1_20079471_ChIP-ChIP_T-47D_Human	1.39303919
33	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.38336651
34	RUNX_20019798_ChIP-Seq_JUKART_Human	1.37742813
35	PPAR_26484153_Chip-Seq_NCI-H1993_Human	1.36349078
36	SPI1_23127762_ChIP-Seq_K562_Human	1.35924448
37	GATA2_21666600_ChIP-Seq_HMVEC_Human	1.35146475
38	TCF4_18268006_ChIP-ChIP_LS174T_Human	1.34260060
39	NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse	1.30906809
40	CDX2_22108803_ChIP-Seq_LS180_Human	1.30004997
41	FOXO1_23066095_ChIP-Seq_LIVER_Mouse	1.26893675
42	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.26077717
43	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.25460969
44	GATA2_19941826_ChIP-Seq_K562_Human	1.24308962
45	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.22457409
46	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	1.20458187
47	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.17648462
48	GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.14086713
49	DROSHA_22980978_ChIP-Seq_HELA_Human	1.10343452
50	AHR_22903824_ChIP-Seq_MCF-7_Human	1.09975724
51	RXR_22108803_ChIP-Seq_LS180_Human	1.08197843
52	MYB_21317192_ChIP-Seq_ERMYB_Mouse	1.08188258
53	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.07339490
54	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	1.05902242
55	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.05558516
56	TP63_23658742_ChIP-Seq_EP156T_Human	1.05467428
57	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.05363551
58	GATA1_19941826_ChIP-Seq_K562_Human	1.04683112
59	PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse	1.03841401
60	FOXA2_19822575_ChIP-Seq_HepG2_Human	1.03254368
61	VDR_24763502_ChIP-Seq_THP-1_Human	0.97552042
62	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.94432168
63	KLF5_25053715_ChIP-Seq_YYC3_Human	0.94064886
64	MYB_26560356_Chip-Seq_TH2_Human	0.92325875
65	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	0.92319836
66	FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse	0.92173191
67	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	0.91654374
68	BCAT_22108803_ChIP-Seq_LS180_Human	0.91489718
69	CJUN_26792858_Chip-Seq_BT549_Human	0.91364598
70	NANOG_20526341_ChIP-Seq_ESCs_Human	0.91147102
71	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	0.90460205
72	GATA1_19941827_ChIP-Seq_MEL_Mouse	0.89046292
73	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.86846001
74	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.86610504
75	SCL_19346495_ChIP-Seq_HPC-7_Human	0.85899483
76	NR1I2_20693526_ChIP-Seq_LIVER_Mouse	0.85073280
77	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.84011411
78	ER_23166858_ChIP-Seq_MCF-7_Human	0.83890896
79	CEBPB_22108803_ChIP-Seq_LS180_Human	0.83688602
80	RUNX1_27514584_Chip-Seq_MCF-7_Human	0.83493699
81	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	0.83486165
82	GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human	0.83063388
83	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.82757095
84	HNF4A_19822575_ChIP-Seq_HepG2_Human	0.82563082
85	FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human	0.81856215
86	ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human	0.81603568
87	GATA3_27048872_Chip-Seq_THYMUS_Human	0.81488737
88	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.81268320
89	MYB_26560356_Chip-Seq_TH1_Human	0.81021657
90	GATA3_26560356_Chip-Seq_TH2_Human	0.80401565
91	ESR2_21235772_ChIP-Seq_MCF-7_Human	0.79586959
92	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	0.79204607
93	CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.78101733
94	WDR5_24793694_ChIP-Seq_LNCAP_Human	0.78099337
95	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.75199197
96	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.73695529
97	PPARG_20176806_ChIP-Seq_3T3-L1_Mouse	0.73527072
98	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.73447310
99	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.73280902
100	P63_26484246_Chip-Seq_KERATINOCYTES_Human	0.73269254

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005360_urolithiasis	6.74602981
2	MP0003183_abnormal_peptide_metabolism	4.08283418
3	MP0005085_abnormal_gallbladder_physiolo	3.88272837
4	MP0003724_increased_susceptibility_to	3.44732233
5	MP0001666_abnormal_nutrient_absorption	3.38905157
6	MP0004264_abnormal_extraembryonic_tissu	3.27093009
7	MP0010234_abnormal_vibrissa_follicle	3.04531362
8	MP0010155_abnormal_intestine_physiology	2.80298860
9	MP0005365_abnormal_bile_salt	2.79931127
10	MP0002139_abnormal_hepatobiliary_system	2.67056375
11	MP0004019_abnormal_vitamin_homeostasis	2.46198268
12	MP0003866_abnormal_defecation	2.38826232
13	MP0004147_increased_porphyrin_level	2.16156996
14	MP0009840_abnormal_foam_cell	2.09741178
15	MP0001664_abnormal_digestion	2.07435425
16	MP0008004_abnormal_stomach_pH	2.04368925
17	MP0005409_darkened_coat_color	1.91372110
18	MP0005451_abnormal_body_composition	1.89453820
19	MP0001835_abnormal_antigen_presentation	1.85369127
20	MP0003303_peritoneal_inflammation	1.83739656
21	MP0005166_decreased_susceptibility_to	1.81479119
22	MP0000465_gastrointestinal_hemorrhage	1.81127176
23	MP0009785_altered_susceptibility_to	1.78545549
24	MP0003300_gastrointestinal_ulcer	1.76029202
25	MP0003252_abnormal_bile_duct	1.73164494
26	MP0003436_decreased_susceptibility_to	1.71445539
27	MP0003806_abnormal_nucleotide_metabolis	1.70888373
28	MP0010352_gastrointestinal_tract_polyps	1.59658595
29	MP0005410_abnormal_fertilization	1.58517983
30	MP0005025_abnormal_response_to	1.52715802
31	MP0005670_abnormal_white_adipose	1.49310402
32	MP0002132_abnormal_respiratory_system	1.47474414
33	MP0010329_abnormal_lipoprotein_level	1.47081989
34	MP0001765_abnormal_ion_homeostasis	1.44603018
35	MP0002138_abnormal_hepatobiliary_system	1.43927831
36	MP0003868_abnormal_feces_composition	1.38438442
37	MP0002419_abnormal_innate_immunity	1.34958598
38	MP0001845_abnormal_inflammatory_respons	1.32865346
39	MP0009643_abnormal_urine_homeostasis	1.31539863
40	MP0001800_abnormal_humoral_immune	1.29354990
41	MP0001663_abnormal_digestive_system	1.25342201
42	MP0005387_immune_system_phenotype	1.23687001
43	MP0001790_abnormal_immune_system	1.23687001
44	MP0009764_decreased_sensitivity_to	1.21900187
45	MP0000477_abnormal_intestine_morphology	1.20620349
46	MP0001501_abnormal_sleep_pattern	1.19429892
47	MP0005310_abnormal_salivary_gland	1.19322024
48	MP0003879_abnormal_hair_cell	1.18208912
49	MP0002166_altered_tumor_susceptibility	1.18002644
50	MP0000678_abnormal_parathyroid_gland	1.15377323
51	MP0008260_abnormal_autophagy	1.13470346
52	MP0004043_abnormal_pH_regulation	1.12845878
53	MP0003045_fibrosis	1.12686993
54	MP0000538_abnormal_urinary_bladder	1.12239406
55	MP0000490_abnormal_crypts_of	1.10521582
56	MP0004947_skin_inflammation	1.07149208
57	MP0002277_abnormal_respiratory_mucosa	1.06561461
58	MP0001533_abnormal_skeleton_physiology	1.06227291
59	MP0002876_abnormal_thyroid_physiology	1.05778643
60	MP0002723_abnormal_immune_serum	1.05655185
61	MP0002396_abnormal_hematopoietic_system	1.05542872
62	MP0008469_abnormal_protein_level	1.04932309
63	MP0005332_abnormal_amino_acid	1.04831176
64	MP0006082_CNS_inflammation	1.04576451
65	MP0002136_abnormal_kidney_physiology	1.03243509
66	MP0001764_abnormal_homeostasis	1.03069569
67	MP0002452_abnormal_antigen_presenting	1.02640503
68	MP0004858_abnormal_nervous_system	1.02014105
69	MP0005000_abnormal_immune_tolerance	1.01705615
70	MP0001873_stomach_inflammation	1.01238514
71	MP0000685_abnormal_immune_system	0.98998678
72	MP0004484_altered_response_of	0.98500391
73	MP0002118_abnormal_lipid_homeostasis	0.98131343
74	MP0005636_abnormal_mineral_homeostasis	0.96663454
75	MP0005381_digestive/alimentary_phenotyp	0.96457330
76	MP0001819_abnormal_immune_cell	0.94784749
77	MP0009115_abnormal_fat_cell	0.94329571
78	MP0002148_abnormal_hypersensitivity_rea	0.94291781
79	MP0002420_abnormal_adaptive_immunity	0.93524385
80	MP0005319_abnormal_enzyme/_coenzyme	0.89603636
81	MP0000609_abnormal_liver_physiology	0.89048345
82	MP0005671_abnormal_response_to	0.88121946
83	MP0000230_abnormal_systemic_arterial	0.86855817
84	MP0005448_abnormal_energy_balance	0.86810138
85	MP0003191_abnormal_cellular_cholesterol	0.86123260
86	MP0002998_abnormal_bone_remodeling	0.83908691
87	MP0003828_pulmonary_edema	0.82450217
88	MP0005535_abnormal_body_temperature	0.82071744
89	MP0005584_abnormal_enzyme/coenzyme_acti	0.78402178
90	MP0001485_abnormal_pinna_reflex	0.77621725
91	MP0001756_abnormal_urination	0.77579947
92	MP0000249_abnormal_blood_vessel	0.77457647
93	MP0004782_abnormal_surfactant_physiolog	0.77423446
94	MP0001188_hyperpigmentation	0.76638414
95	MP0005174_abnormal_tail_pigmentation	0.74588543
96	MP0005164_abnormal_response_to	0.74436152
97	MP0000015_abnormal_ear_pigmentation	0.73733650
98	MP0005248_abnormal_Harderian_gland	0.73042371
99	MP0002971_abnormal_brown_adipose	0.71288050
100	MP0005464_abnormal_platelet_physiology	0.70707228

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glutamine family amino acid metabolism (HP:0010902)	6.88235584
2	Malnutrition (HP:0004395)	5.81515700
3	Chronic diarrhea (HP:0002028)	4.61165841
4	Eczematoid dermatitis (HP:0000976)	4.57620892
5	Abnormality of proline metabolism (HP:0010907)	4.31962287
6	Hydroxyprolinuria (HP:0003080)	4.31962287
7	Ileus (HP:0002595)	4.25470768
8	Acanthocytosis (HP:0001927)	4.25315724
9	Widely patent fontanelles and sutures (HP:0004492)	4.02903155
10	Hypobetalipoproteinemia (HP:0003563)	3.90850521
11	Pigmentary retinal degeneration (HP:0001146)	3.71647760
12	Fat malabsorption (HP:0002630)	3.60644789
13	Orchitis (HP:0100796)	3.50252563
14	Congenital sensorineural hearing impairment (HP:0008527)	3.46706219
15	Right ventricular cardiomyopathy (HP:0011663)	3.45502957
16	Abnormality of the vitamin B12 metabolism (HP:0004341)	3.40231148
17	Gingivitis (HP:0000230)	3.35935188
18	Abnormality of vitamin B metabolism (HP:0004340)	3.29519964
19	Hyperactive renin-angiotensin system (HP:0000841)	3.22879613
20	Myositis (HP:0100614)	3.15306821
21	Retrobulbar optic neuritis (HP:0100654)	3.05746543
22	Optic neuritis (HP:0100653)	3.05746543
23	Gastrointestinal infarctions (HP:0005244)	3.00162490
24	Decreased circulating renin level (HP:0003351)	2.97803685
25	Systemic lupus erythematosus (HP:0002725)	2.88730126
26	Recurrent bacterial skin infections (HP:0005406)	2.87889174
27	Recurrent abscess formation (HP:0002722)	2.85986781
28	Thin bony cortex (HP:0002753)	2.84201281
29	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.84071393
30	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.73283552
31	Enlarged epiphyses (HP:0010580)	2.64190862
32	Abnormality of macrophages (HP:0004311)	2.62198487
33	Abnormality of vitamin metabolism (HP:0100508)	2.59416330
34	Spontaneous hematomas (HP:0007420)	2.59409043
35	Abdominal distention (HP:0003270)	2.58738303
36	Metabolic alkalosis (HP:0200114)	2.57688143
37	Wide cranial sutures (HP:0010537)	2.51010189
38	Peritonitis (HP:0002586)	2.50936246
39	Inflammation of the large intestine (HP:0002037)	2.48708340
40	Ventricular fibrillation (HP:0001663)	2.44963829
41	Abnormality of renin-angiotensin system (HP:0000847)	2.42065231
42	Gingival bleeding (HP:0000225)	2.38011879
43	Keratoconjunctivitis sicca (HP:0001097)	2.37363308
44	Vasculitis (HP:0002633)	2.33513222
45	Hemorrhage of the eye (HP:0011885)	2.33113607
46	Abnormality of urine glucose concentration (HP:0011016)	2.32225602
47	Glycosuria (HP:0003076)	2.32225602
48	Recurrent gram-negative bacterial infections (HP:0005420)	2.29723651
49	Confusion (HP:0001289)	2.28026456
50	Facial shape deformation (HP:0011334)	2.27512653
51	Potter facies (HP:0002009)	2.27512653
52	Colitis (HP:0002583)	2.26909745
53	Gastrointestinal inflammation (HP:0004386)	2.26618154
54	Alkalosis (HP:0001948)	2.21731027
55	Hypophosphatemia (HP:0002148)	2.21015467
56	Abnormal biliary tract morphology (HP:0012440)	2.19763233
57	Keratoconjunctivitis (HP:0001096)	2.17948368
58	Abnormality of the costochondral junction (HP:0000919)	2.17096617
59	Encephalitis (HP:0002383)	2.16562178
60	Resting tremor (HP:0002322)	2.15539649
61	Nephrolithiasis (HP:0000787)	2.13895457
62	Hemoptysis (HP:0002105)	2.13826040
63	Proximal tubulopathy (HP:0000114)	2.12670495
64	Elevated erythrocyte sedimentation rate (HP:0003565)	2.10084461
65	Abnormal delayed hypersensitivity skin test (HP:0002963)	2.08945971
66	Focal segmental glomerulosclerosis (HP:0000097)	2.03536735
67	Petechiae (HP:0000967)	2.03494255
68	Poikilocytosis (HP:0004447)	2.01210367
69	Recurrent fungal infections (HP:0002841)	2.00868897
70	Segmental peripheral demyelination/remyelination (HP:0003481)	2.00755941
71	Villous atrophy (HP:0011473)	2.00445996
72	Abnormality of small intestinal villus morphology (HP:0011472)	2.00445996
73	Hypolipoproteinemia (HP:0010981)	1.97857565
74	Prolonged bleeding time (HP:0003010)	1.96099023
75	Steatorrhea (HP:0002570)	1.95623010
76	Abnormality of chloride homeostasis (HP:0011422)	1.90459619
77	Chest pain (HP:0100749)	1.89656341
78	Pancreatitis (HP:0001733)	1.89592564
79	Obstructive lung disease (HP:0006536)	1.89290857
80	Chronic obstructive pulmonary disease (HP:0006510)	1.89290857
81	Xanthomatosis (HP:0000991)	1.89085317
82	Protuberant abdomen (HP:0001538)	1.88948055
83	Recurrent skin infections (HP:0001581)	1.88793624
84	Conjugated hyperbilirubinemia (HP:0002908)	1.88080977
85	Postural instability (HP:0002172)	1.86670005
86	Premature loss of primary teeth (HP:0006323)	1.84344525
87	Osteomalacia (HP:0002749)	1.82564608
88	Cheilitis (HP:0100825)	1.82427043
89	Nausea (HP:0002018)	1.82053866
90	Arterial thrombosis (HP:0004420)	1.79862487
91	Amyloidosis (HP:0011034)	1.79837817
92	Flat acetabular roof (HP:0003180)	1.79617290
93	Urticaria (HP:0001025)	1.78906078
94	Meningitis (HP:0001287)	1.77593135
95	Leukocytosis (HP:0001974)	1.77337598
96	Gastrointestinal dysmotility (HP:0002579)	1.75616661
97	Syncope (HP:0001279)	1.74161396
98	Hypotension (HP:0002615)	1.72660055
99	Cone-rod dystrophy (HP:0000548)	1.71726431
100	Hyperparathyroidism (HP:0000843)	1.70236999

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ACVR1B	4.93051369
2	MST1R	3.33142363
3	ERN1	2.79584326
4	PRKG2	2.60394774
5	RIPK4	2.58782231
6	PINK1	2.52100323
7	FRK	2.46350994
8	RIPK1	2.45166132
9	STK39	2.12944228
10	MAP3K2	2.10657882
11	OXSR1	1.99700320
12	LMTK2	1.94410013
13	EPHB1	1.94227424
14	MAP3K10	1.90901491
15	TYK2	1.86159780
16	MAP3K1	1.77795758
17	BLK	1.73646103
18	IRAK4	1.73377060
19	GRK6	1.59557041
20	EPHA3	1.50060817
21	MAP3K13	1.47987032
22	FGFR4	1.47666277
23	FGFR3	1.47049478
24	CSK	1.44030784
25	IRAK1	1.36785752
26	MAP4K1	1.36470792
27	TAOK1	1.35846401
28	EPHA2	1.33321828
29	MARK3	1.30308476
30	NLK	1.26040151
31	MET	1.23720942
32	PIK3CA	1.23307427
33	MAP3K14	1.19813449
34	MATK	1.18963894
35	FGR	1.15343044
36	PTK6	1.10794775
37	JAK2	1.08713033
38	JAK3	1.08708978
39	MAP3K3	1.08535119
40	KSR2	1.07140128
41	BTK	1.05643723
42	YES1	1.04116455
43	ZAP70	1.02895868
44	PIK3CG	1.02879880
45	MAP2K3	1.01258748
46	AKT3	1.01131469
47	PDPK1	0.98972783
48	IKBKE	0.98072514
49	CDC42BPA	0.95663416
50	JAK1	0.92596101
51	DDR2	0.92025623
52	STK38	0.90528330
53	PDK1	0.90018777
54	PRKAA2	0.87434185
55	IRAK2	0.83858425
56	ERBB2	0.81635379
57	CDK12	0.79008080
58	SYK	0.76125122
59	STK24	0.76116627
60	TAOK3	0.76063355
61	RET	0.76045942
62	WNK1	0.75856381
63	STK38L	0.75719911
64	PTK2B	0.75243543
65	MYLK	0.74602923
66	MAP3K6	0.72570004
67	HCK	0.68084035
68	BMPR2	0.63258492
69	LYN	0.62699045
70	MAP2K6	0.61763675
71	FER	0.59741558
72	SGK494	0.57327945
73	SGK223	0.57327945
74	SGK2	0.56997270
75	KIT	0.54787216
76	LATS1	0.53574689
77	TEC	0.52913763
78	MAP3K7	0.52063486
79	PRPF4B	0.51579474
80	ITK	0.51542760
81	SGK3	0.49072220
82	TXK	0.48951973
83	TNK2	0.48571207
84	PRKCQ	0.48488656
85	TNIK	0.47874447
86	NEK6	0.46217737
87	PRKCZ	0.46059015
88	FES	0.45407442
89	MAP3K5	0.45324883
90	MAPK11	0.45216734
91	TBK1	0.43607339
92	DYRK1B	0.42505420
93	FYN	0.40346291
94	LCK	0.39898192
95	PIM1	0.38747577
96	CSF1R	0.37591528
97	MELK	0.36948567
98	MAP3K11	0.35771610
99	MARK2	0.33388365
100	SGK1	0.31301723

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Vitamin digestion and absorption_Homo sapiens_hsa04977	3.31583479
2	Cyanoamino acid metabolism_Homo sapiens_hsa00460	3.30607832
3	Fat digestion and absorption_Homo sapiens_hsa04975	3.11665417
4	Renin-angiotensin system_Homo sapiens_hsa04614	3.09671697
5	Mineral absorption_Homo sapiens_hsa04978	2.24493190
6	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	2.24492533
7	Caffeine metabolism_Homo sapiens_hsa00232	2.22139488
8	Starch and sucrose metabolism_Homo sapiens_hsa00500	2.14077336
9	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	2.09253250
10	Protein digestion and absorption_Homo sapiens_hsa04974	2.09073899
11	Arginine biosynthesis_Homo sapiens_hsa00220	1.95593752
12	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.87305378
13	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.80541067
14	Histidine metabolism_Homo sapiens_hsa00340	1.65197179
15	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.56190192
16	Galactose metabolism_Homo sapiens_hsa00052	1.54217471
17	PPAR signaling pathway_Homo sapiens_hsa03320	1.51470839
18	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.50632353
19	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.49798372
20	Chemical carcinogenesis_Homo sapiens_hsa05204	1.48405978
21	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.47599161
22	Linoleic acid metabolism_Homo sapiens_hsa00591	1.47039558
23	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.45245233
24	Retinol metabolism_Homo sapiens_hsa00830	1.44962909
25	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.44324200
26	Bile secretion_Homo sapiens_hsa04976	1.42594381
27	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.41467465
28	Leishmaniasis_Homo sapiens_hsa05140	1.33865526
29	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.30481021
30	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.24358302
31	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.21704925
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.16406757
33	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.11531036
34	Glycerolipid metabolism_Homo sapiens_hsa00561	1.03098537
35	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.98843812
36	Pancreatic secretion_Homo sapiens_hsa04972	0.93978196
37	Graft-versus-host disease_Homo sapiens_hsa05332	0.92299856
38	Sulfur metabolism_Homo sapiens_hsa00920	0.91966522
39	Allograft rejection_Homo sapiens_hsa05330	0.91410097
40	Osteoclast differentiation_Homo sapiens_hsa04380	0.90453873
41	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.85548906
42	Tuberculosis_Homo sapiens_hsa05152	0.85412894
43	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.82449756
44	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.81312571
45	Ether lipid metabolism_Homo sapiens_hsa00565	0.79891134
46	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.79419236
47	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.78662452
48	Fatty acid degradation_Homo sapiens_hsa00071	0.76967254
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.75392422
50	Chagas disease (American trypanosomiasis)_Homo sapiens_hsa05142	0.74036452
51	Chemokine signaling pathway_Homo sapiens_hsa04062	0.73419650
52	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.73417981
53	Type I diabetes mellitus_Homo sapiens_hsa04940	0.71015176
54	Tryptophan metabolism_Homo sapiens_hsa00380	0.70581338
55	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.67995903
56	ABC transporters_Homo sapiens_hsa02010	0.67808308
57	Renin secretion_Homo sapiens_hsa04924	0.67692584
58	Insulin resistance_Homo sapiens_hsa04931	0.67210540
59	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.66893670
60	Influenza A_Homo sapiens_hsa05164	0.66636356
61	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.66635082
62	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.66497864
63	Hepatitis C_Homo sapiens_hsa05160	0.66317910
64	Toxoplasmosis_Homo sapiens_hsa05145	0.65738533
65	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	0.63730381
66	Asthma_Homo sapiens_hsa05310	0.63391393
67	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.63123735
68	TNF signaling pathway_Homo sapiens_hsa04668	0.61240081
69	Sphingolipid metabolism_Homo sapiens_hsa00600	0.59083094
70	Arginine and proline metabolism_Homo sapiens_hsa00330	0.58922168
71	African trypanosomiasis_Homo sapiens_hsa05143	0.58540815
72	Leukocyte transendothelial migration_Homo sapiens_hsa04670	0.58227321
73	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.52250938
74	Phenylalanine metabolism_Homo sapiens_hsa00360	0.52149716
75	Platelet activation_Homo sapiens_hsa04611	0.52148290
76	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.48564257
77	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.47574779
78	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.47480565
79	Pertussis_Homo sapiens_hsa05133	0.47262308
80	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.46260895
81	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.46164294
82	Phagosome_Homo sapiens_hsa04145	0.45090174
83	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.44229181
84	Acute myeloid leukemia_Homo sapiens_hsa05221	0.42287686
85	Nitrogen metabolism_Homo sapiens_hsa00910	0.41808114
86	Prolactin signaling pathway_Homo sapiens_hsa04917	0.40958695
87	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.40121441
88	Gap junction_Homo sapiens_hsa04540	0.40031993
89	Antigen processing and presentation_Homo sapiens_hsa04612	0.39689637
90	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.38021401
91	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.37282186
92	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36991699
93	GnRH signaling pathway_Homo sapiens_hsa04912	0.36981495
94	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.36919941
95	Legionellosis_Homo sapiens_hsa05134	0.36230136
96	Apoptosis_Homo sapiens_hsa04210	0.36042193
97	Amoebiasis_Homo sapiens_hsa05146	0.34351460
98	Choline metabolism in cancer_Homo sapiens_hsa05231	0.33132411
99	FoxO signaling pathway_Homo sapiens_hsa04068	0.32584172
100	Malaria_Homo sapiens_hsa05144	0.30000953

MGAM2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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