MGARP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1otic vesicle formation (GO:0030916)8.86506471
2regulation of branching involved in salivary gland morphogenesis (GO:0060693)8.24001081
3G-protein coupled glutamate receptor signaling pathway (GO:0007216)8.02441769
4lateral sprouting from an epithelium (GO:0060601)8.02152990
5relaxation of smooth muscle (GO:0044557)7.93670718
6radial glial cell differentiation (GO:0060019)7.80215308
7response to pheromone (GO:0019236)7.68136118
8cellular potassium ion homeostasis (GO:0030007)7.63092922
9positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr7.52330924
10sodium ion export (GO:0071436)7.37554902
11embryonic camera-type eye development (GO:0031076)6.86233287
12positive regulation of synapse maturation (GO:0090129)6.83640697
13skeletal muscle adaptation (GO:0043501)6.81383502
14potassium ion homeostasis (GO:0055075)6.81269045
15regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 6.54659544
16negative regulation of stress fiber assembly (GO:0051497)6.49172016
17response to follicle-stimulating hormone (GO:0032354)6.43441774
18lung epithelium development (GO:0060428)6.23723602
19muscle cell fate commitment (GO:0042693)6.22651820
20limb bud formation (GO:0060174)5.95537882
21C21-steroid hormone biosynthetic process (GO:0006700)5.94356806
22gamma-aminobutyric acid signaling pathway (GO:0007214)5.93473581
23protein localization to cell surface (GO:0034394)5.92814286
24camera-type eye morphogenesis (GO:0048593)5.86365255
25negative regulation of Rho protein signal transduction (GO:0035024)5.86280568
26synaptic vesicle exocytosis (GO:0016079)5.71281616
27neuronal ion channel clustering (GO:0045161)5.64343558
28urinary tract smooth muscle contraction (GO:0014848)5.59434791
29cell communication by electrical coupling involved in cardiac conduction (GO:0086064)5.57919983
30cellular response to follicle-stimulating hormone stimulus (GO:0071372)5.54224793
31retinal cone cell development (GO:0046549)5.46737722
32peripheral nervous system axon ensheathment (GO:0032292)5.46578031
33myelination in peripheral nervous system (GO:0022011)5.46578031
34synaptic vesicle endocytosis (GO:0048488)5.41535016
35organ growth (GO:0035265)5.41222026
36regulation of synapse maturation (GO:0090128)5.34529281
37mesonephros development (GO:0001823)5.07522496
38genitalia morphogenesis (GO:0035112)5.05782990
39branch elongation of an epithelium (GO:0060602)5.05250794
40photoreceptor cell development (GO:0042461)5.04254827
41eye photoreceptor cell development (GO:0042462)5.02280130
42androgen biosynthetic process (GO:0006702)4.94798287
43rhodopsin mediated signaling pathway (GO:0016056)4.82185102
44negative regulation of actin filament bundle assembly (GO:0032232)4.79240640
45cellular sodium ion homeostasis (GO:0006883)4.78300156
46kidney morphogenesis (GO:0060993)4.72952071
47cell communication by electrical coupling (GO:0010644)4.72706299
48positive regulation of focal adhesion assembly (GO:0051894)4.71286020
49positive regulation of cell junction assembly (GO:1901890)4.71286020
50mating behavior (GO:0007617)4.69223508
51positive regulation of dendritic spine morphogenesis (GO:0061003)4.69155433
52progesterone metabolic process (GO:0042448)4.66696685
53protein localization to synapse (GO:0035418)4.62571334
54induction of positive chemotaxis (GO:0050930)4.61174225
55glucocorticoid metabolic process (GO:0008211)4.59135933
56innervation (GO:0060384)4.57261154
57positive regulation of adherens junction organization (GO:1903393)4.54562359
58lung secretory cell differentiation (GO:0061140)4.53591753
59bicarbonate transport (GO:0015701)4.49136412
60photoreceptor cell maintenance (GO:0045494)4.48840694
61white fat cell differentiation (GO:0050872)4.46822336
62cellular response to antibiotic (GO:0071236)4.43233252
63embryonic digestive tract morphogenesis (GO:0048557)4.40802788
64cell migration involved in heart development (GO:0060973)4.37138729
65potassium ion export (GO:0071435)4.36655579
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)4.32193514
67positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.30900383
68regulation of mitochondrial depolarization (GO:0051900)4.23983287
69striatum development (GO:0021756)4.23118813
70organ induction (GO:0001759)4.20183750
71axis elongation (GO:0003401)4.16268080
72neurotransmitter-gated ion channel clustering (GO:0072578)4.13324000
73venous blood vessel morphogenesis (GO:0048845)4.06943775
74sensory perception of light stimulus (GO:0050953)4.05333657
75positive regulation of gastrulation (GO:2000543)4.01941124
76visual perception (GO:0007601)4.00676130
77keratinocyte proliferation (GO:0043616)3.95607462
78organ formation (GO:0048645)3.94669769
79regulation of synaptic vesicle exocytosis (GO:2000300)3.94211896
80peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.93582275
81smooth muscle cell differentiation (GO:0051145)3.93304498
82calcium ion import (GO:0070509)3.90602860
83striated muscle hypertrophy (GO:0014897)3.87481275
84positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.86401741
85morphogenesis of an epithelial fold (GO:0060571)3.85972002
86iron coordination entity transport (GO:1901678)3.84737786
87synaptic vesicle transport (GO:0048489)3.81148793
88establishment of synaptic vesicle localization (GO:0097480)3.81148793
89glycolytic process (GO:0006096)3.79886634
90regulation of rhodopsin mediated signaling pathway (GO:0022400)3.79389662
91regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.76248663
92regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.76248663
93cellular response to gonadotropin stimulus (GO:0071371)3.70079145
94C21-steroid hormone metabolic process (GO:0008207)3.66238785
95pyrimidine dimer repair (GO:0006290)3.65873690
96substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.63263853
97substrate-independent telencephalic tangential migration (GO:0021826)3.63263853
98bone trabecula formation (GO:0060346)3.62359417
99collagen catabolic process (GO:0030574)3.61706250
100protein-chromophore linkage (GO:0018298)3.60129633
101response to host (GO:0075136)3.59924284
102response to host defenses (GO:0052200)3.59924284
103response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.59924284
104non-canonical Wnt signaling pathway (GO:0035567)3.56953723
105synaptic vesicle maturation (GO:0016188)3.56861125
106nitric oxide mediated signal transduction (GO:0007263)3.56035133
107response to leptin (GO:0044321)3.55841887
108collagen metabolic process (GO:0032963)3.54966371
109positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.51943868
110regulation of short-term neuronal synaptic plasticity (GO:0048172)3.51943223
111response to gonadotropin (GO:0034698)3.50094634
112peptidyl-proline hydroxylation (GO:0019511)3.49812883
113negative regulation of cell-matrix adhesion (GO:0001953)3.46983900
114GMP metabolic process (GO:0046037)3.41345237
115regulation of keratinocyte proliferation (GO:0010837)3.41275918
116detection of visible light (GO:0009584)3.41265909
117positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.39294769
118membrane hyperpolarization (GO:0060081)3.37731581
119response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.37585467
120response to host immune response (GO:0052572)3.37585467
121retina development in camera-type eye (GO:0060041)3.36651049
122detection of light stimulus (GO:0009583)3.35290726
123atrial cardiac muscle cell action potential (GO:0086014)3.34859455
124glutamate receptor signaling pathway (GO:0007215)3.34681633
125membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.33452723
126regulation of voltage-gated calcium channel activity (GO:1901385)3.32414742
127cardiac muscle cell proliferation (GO:0060038)3.31489110
128multicellular organismal macromolecule metabolic process (GO:0044259)3.30972104
129membrane depolarization during action potential (GO:0086010)3.29802988
130muscle hypertrophy (GO:0014896)3.29454801
131multicellular organismal catabolic process (GO:0044243)3.26955973
132positive regulation of steroid biosynthetic process (GO:0010893)3.26943332
133positive regulation of TOR signaling (GO:0032008)3.25492316
134striated muscle cell proliferation (GO:0014855)3.23812619
135regulation of synaptic transmission, glutamatergic (GO:0051966)3.23729786
136negative regulation of cell cycle arrest (GO:0071157)3.23630565
137prepulse inhibition (GO:0060134)3.21680454
138positive regulation of cGMP biosynthetic process (GO:0030828)3.21679439
139positive regulation of calcium ion import (GO:0090280)3.20748013
140regulation of transforming growth factor beta2 production (GO:0032909)3.19209100
141regulation of secondary heart field cardioblast proliferation (GO:0003266)3.18133519
142regulation of cardioblast proliferation (GO:0003264)3.18133519
143multicellular organismal metabolic process (GO:0044236)3.16169915
144thyroid gland development (GO:0030878)3.15360711
145negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.14967738
146regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.13536418
147nonmotile primary cilium assembly (GO:0035058)3.13351234
148cellular response to toxic substance (GO:0097237)3.11236340
149negative regulation of fibroblast apoptotic process (GO:2000270)3.11205251
150glucocorticoid biosynthetic process (GO:0006704)3.08468730
151positive regulation of cyclin-dependent protein serine/threonine kinase activity (GO:0045737)3.08368266
152behavioral response to ethanol (GO:0048149)3.08178290
153estrogen biosynthetic process (GO:0006703)3.07954114
154positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.07898660
155mesenchymal cell differentiation (GO:0048762)3.07761306
156cGMP biosynthetic process (GO:0006182)3.07704648
157ventricular cardiac muscle cell development (GO:0055015)3.07544807
158regulation of synaptic vesicle transport (GO:1902803)3.07055947
159peristalsis (GO:0030432)3.07048590
160negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.06006615
161synapse assembly (GO:0007416)3.05022923
162eye morphogenesis (GO:0048592)3.01909435
163regulation of cGMP biosynthetic process (GO:0030826)3.01764703
164regulation of bile acid biosynthetic process (GO:0070857)3.01304353
165layer formation in cerebral cortex (GO:0021819)2.99673134
166collagen fibril organization (GO:0030199)2.99415229
167phagocytosis, recognition (GO:0006910)2.99017110
168phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.98128136
169sodium ion homeostasis (GO:0055078)2.97954640
170ERK1 and ERK2 cascade (GO:0070371)2.97817989
1714-hydroxyproline metabolic process (GO:0019471)2.96358975
172detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.94967552
173detection of temperature stimulus involved in sensory perception (GO:0050961)2.94967552
174lactate metabolic process (GO:0006089)2.94745722
175lymph vessel development (GO:0001945)2.94599343
176cellular response to light stimulus (GO:0071482)2.94024845
177response to histamine (GO:0034776)2.94005801
178regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.93936219
179regulation of cholesterol homeostasis (GO:2000188)2.93371703
180regulation of cGMP metabolic process (GO:0030823)2.90620809
181protein hydroxylation (GO:0018126)2.90480993
182establishment of mitotic spindle orientation (GO:0000132)2.89049081
183negative regulation of osteoblast proliferation (GO:0033689)2.88693035
184positive regulation of male gonad development (GO:2000020)2.86986700
185adhesion of symbiont to host (GO:0044406)2.85198273
186regulation of organ formation (GO:0003156)2.83201121
187hormone biosynthetic process (GO:0042446)2.82958720
188prostate gland epithelium morphogenesis (GO:0060740)2.81701078
189positive regulation of hormone biosynthetic process (GO:0046886)2.77844087
190striated muscle adaptation (GO:0014888)2.75248639
191glomerular basement membrane development (GO:0032836)12.6923255
192detection of light stimulus involved in sensory perception (GO:0050962)12.2689061
193detection of light stimulus involved in visual perception (GO:0050908)12.2689061
194negative regulation of cytosolic calcium ion concentration (GO:0051481)10.2321961
195mesenchymal-epithelial cell signaling (GO:0060638)10.2228056
196retinal rod cell development (GO:0046548)10.1068966

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GLI1_17442700_ChIP-ChIP_MESCs_Mouse4.66145314
2GBX2_23144817_ChIP-Seq_PC3_Human3.91802275
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.70509698
4ZFP322A_24550733_ChIP-Seq_MESCs_Mouse3.52359215
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.95874253
6ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.88142206
7REST_21632747_ChIP-Seq_MESCs_Mouse2.77210706
8RARG_19884340_ChIP-ChIP_MEFs_Mouse2.63553577
9PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.62927373
10EP300_21415370_ChIP-Seq_HL-1_Mouse2.60674819
11EZH2_27294783_Chip-Seq_ESCs_Mouse2.59348146
12DROSHA_22980978_ChIP-Seq_HELA_Human2.55780340
13TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.54590777
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52371878
15PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.51128332
16CLOCK_20551151_ChIP-Seq_293T_Human2.50215111
17P53_22127205_ChIP-Seq_FIBROBLAST_Human2.46551965
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32519550
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26495912
20SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26410800
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25924566
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25159398
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.24983003
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.24270132
25SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.22723094
26SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15586937
27AR_21572438_ChIP-Seq_LNCaP_Human2.14284676
28RNF2_27304074_Chip-Seq_ESCs_Mouse2.08897740
29CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02939193
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.01137084
31MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94953254
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.94907741
33STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.92979070
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.91326521
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90797315
36EGR1_19032775_ChIP-ChIP_M12_Human1.90335580
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.87030258
38TP53_20018659_ChIP-ChIP_R1E_Mouse1.85266812
39EED_16625203_ChIP-ChIP_MESCs_Mouse1.83709740
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.82752595
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.81371897
42EZH2_18974828_ChIP-Seq_MESCs_Mouse1.79108434
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.79108434
44EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77961297
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.76984697
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.76558788
47CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.76457658
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.73970736
49FUS_26573619_Chip-Seq_HEK293_Human1.70295572
50ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67858032
51TP53_18474530_ChIP-ChIP_U2OS_Human1.65364598
52CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.64214376
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.63123344
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.62867945
55EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.62072915
56POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.59326241
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.57922918
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.57922918
59MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55149712
60SMAD4_21799915_ChIP-Seq_A2780_Human1.52319557
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.52136928
62CTNNB1_20460455_ChIP-Seq_HCT116_Human1.50778866
63PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.46496788
64TAF15_26573619_Chip-Seq_HEK293_Human1.45971965
65SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.45086737
66TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44379914
67TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.44096017
68RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.43655191
69TP63_17297297_ChIP-ChIP_HaCaT_Human1.41583859
70HIF1A_21447827_ChIP-Seq_MCF-7_Human1.39681587
71VDR_22108803_ChIP-Seq_LS180_Human1.39610219
72SMAD3_21741376_ChIP-Seq_HESCs_Human1.39235372
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.38905015
74AR_25329375_ChIP-Seq_VCAP_Human1.38350215
75TP53_16413492_ChIP-PET_HCT116_Human1.38309094
76ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.37679795
77RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36648146
78NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse1.36043017
79IGF1R_20145208_ChIP-Seq_DFB_Human1.34850827
80RNF2_27304074_Chip-Seq_NSC_Mouse1.32057008
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31968534
82SOX9_24532713_ChIP-Seq_HFSC_Mouse1.31562399
83RING1B_27294783_Chip-Seq_ESCs_Mouse1.31428793
84MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31144615
85PIAS1_25552417_ChIP-Seq_VCAP_Human1.30635508
86BRD4_25478319_ChIP-Seq_HGPS_Human1.28409873
87AR_19668381_ChIP-Seq_PC3_Human1.27132974
88SMAD3_21741376_ChIP-Seq_EPCs_Human1.26640936
89ISL1_27105846_Chip-Seq_CPCs_Mouse1.26130285
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25858996
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25443303
92WT1_19549856_ChIP-ChIP_CCG9911_Human1.24918634
93FLI1_21867929_ChIP-Seq_TH2_Mouse1.24359230
94CJUN_26792858_Chip-Seq_BT549_Human1.23725283
95TCF4_18268006_ChIP-ChIP_LS174T_Human1.21579050
96TP63_19390658_ChIP-ChIP_HaCaT_Human1.21131014
97PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20580225
98P300_19829295_ChIP-Seq_ESCs_Human1.19229499
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17410000
100ELK4_26923725_Chip-Seq_MESODERM_Mouse1.16692177
101CDX2_19796622_ChIP-Seq_MESCs_Mouse1.16201080
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15826278
103TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15364013
104ESR2_21235772_ChIP-Seq_MCF-7_Human1.13662872
105SMAD4_21741376_ChIP-Seq_HESCs_Human1.12815574
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.12769327
107SALL4_18804426_ChIP-ChIP_XEN_Mouse1.12753106
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12193630
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.11565968
110SMC1_22415368_ChIP-Seq_MEFs_Mouse1.09940205
111NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09571414
112FOXO3_23340844_ChIP-Seq_DLD1_Human1.09517532
113STAT3_23295773_ChIP-Seq_U87_Human1.09419568
114PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09310977
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.08883054
116MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08232601
117TRIM28_21343339_ChIP-Seq_HEK293_Human1.07682610
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07082187
119CBP_20019798_ChIP-Seq_JUKART_Human1.07082187
120CTCF_27219007_Chip-Seq_Bcells_Human1.05904879
121TCF4_23295773_ChIP-Seq_U87_Human1.05660638
122TBX20_22080862_ChIP-Seq_HEART_Mouse1.05280988
123TBX20_22328084_ChIP-Seq_HEART_Mouse1.05280988
124DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.04929676
125ERG_21242973_ChIP-ChIP_JURKAT_Human1.04585330
126RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.03976896
127OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03627820
128SMAD_19615063_ChIP-ChIP_OVARY_Human1.03620499
129YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03313187
130TBX3_20139965_ChIP-Seq_ESCs_Mouse1.02616196
131EOMES_21245162_ChIP-Seq_HESCs_Human1.02566837
132MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.02244561
133RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02124803
134TBX3_20139965_ChIP-Seq_MESCs_Mouse1.01888472
135ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00716419
136SOX2_21211035_ChIP-Seq_LN229_Gbm1.00585145
137AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.00219357
138SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.00040628
139UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.99963422
140SA1_22415368_ChIP-Seq_MEFs_Mouse0.99929459
141KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.99870043
142CBP_21632823_ChIP-Seq_H3396_Human0.99582427
143GATA1_26923725_Chip-Seq_HPCs_Mouse0.99092021
144* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.98765537
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98526901
146TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98333794
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.97545954
148LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97249391
149TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96745605
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96042324
151CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.95849550
152SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95788187
153RING1B_27294783_Chip-Seq_NPCs_Mouse0.95681481
154SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94949796
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94158570
156ER_23166858_ChIP-Seq_MCF-7_Human0.93766447
157SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92866674
158DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92458828
159SOX9_26525672_Chip-Seq_HEART_Mouse0.90923590
160CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90321380
161TP53_23651856_ChIP-Seq_MEFs_Mouse0.90170204
162GATA2_21666600_ChIP-Seq_HMVEC_Human0.89149741
163SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.88931456
164GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87801860
165TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87399580
166TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.87171707
167TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85442424

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003878_abnormal_ear_physiology7.97118639
2MP0005377_hearing/vestibular/ear_phenot7.97118639
3MP0005551_abnormal_eye_electrophysiolog7.49946747
4MP0005257_abnormal_intraocular_pressure7.31112590
5MP0002102_abnormal_ear_morphology5.85552585
6MP0006072_abnormal_retinal_apoptosis5.35255787
7MP0002090_abnormal_vision5.25141203
8MP0001984_abnormal_olfaction4.88293731
9MP0005253_abnormal_eye_physiology3.97652362
10MP0005503_abnormal_tendon_morphology3.36324769
11MP0004272_abnormal_basement_membrane3.29741017
12MP0004233_abnormal_muscle_weight3.13157756
13MP0003011_delayed_dark_adaptation3.05599476
14MP0006292_abnormal_olfactory_placode3.01027515
15MP0002132_abnormal_respiratory_system2.98048655
16MP0001502_abnormal_circadian_rhythm2.95745244
17MP0005195_abnormal_posterior_eye2.87762009
18MP0003950_abnormal_plasma_membrane2.72567095
19MP0008438_abnormal_cutaneous_collagen2.65851610
20MP0004782_abnormal_surfactant_physiolog2.62901257
21MP0001346_abnormal_lacrimal_gland2.50442840
22MP0002638_abnormal_pupillary_reflex2.49646769
23MP0010386_abnormal_urinary_bladder2.47381364
24MP0005248_abnormal_Harderian_gland2.45328415
25MP0004084_abnormal_cardiac_muscle2.36420690
26MP0003941_abnormal_skin_development2.31557615
27MP0008775_abnormal_heart_ventricle2.15685266
28MP0004036_abnormal_muscle_relaxation2.12691589
29MP0010030_abnormal_orbit_morphology1.86221770
30MP0005391_vision/eye_phenotype1.85589383
31MP0001324_abnormal_eye_pigmentation1.85572859
32MP0000639_abnormal_adrenal_gland1.81593618
33MP0009250_abnormal_appendicular_skeleto1.79923076
34MP0002229_neurodegeneration1.79082619
35MP0005499_abnormal_olfactory_system1.75638823
36MP0005394_taste/olfaction_phenotype1.75638823
37MP0003880_abnormal_central_pattern1.74323413
38MP0001188_hyperpigmentation1.73383831
39MP0008789_abnormal_olfactory_epithelium1.71712010
40MP0005670_abnormal_white_adipose1.70700954
41MP0004215_abnormal_myocardial_fiber1.65258042
42MP0009046_muscle_twitch1.62483883
43MP0002295_abnormal_pulmonary_circulatio1.60206273
44MP0002752_abnormal_somatic_nervous1.58374704
45MP0005193_abnormal_anterior_eye1.54594370
46MP0002909_abnormal_adrenal_gland1.53884437
47MP0002272_abnormal_nervous_system1.52475279
48MP0002332_abnormal_exercise_endurance1.50361412
49MP0005423_abnormal_somatic_nervous1.50313744
50MP0002184_abnormal_innervation1.48368299
51MP0002234_abnormal_pharynx_morphology1.47180290
52MP0001486_abnormal_startle_reflex1.41927427
53MP0003635_abnormal_synaptic_transmissio1.41597975
54MP0002734_abnormal_mechanical_nocicepti1.41284995
55MP0005595_abnormal_vascular_smooth1.39984308
56MP0002067_abnormal_sensory_capabilities1.37752278
57MP0003279_aneurysm1.36829632
58MP0000631_abnormal_neuroendocrine_gland1.33577549
59MP0005197_abnormal_uvea_morphology1.29514477
60MP0001756_abnormal_urination1.28436523
61MP0005275_abnormal_skin_tensile1.26195269
62MP0002064_seizures1.26023916
63MP0005508_abnormal_skeleton_morphology1.22641900
64MP0001529_abnormal_vocalization1.19307798
65MP0003879_abnormal_hair_cell1.19185086
66MP0001299_abnormal_eye_distance/1.18212000
67MP0002882_abnormal_neuron_morphology1.17933768
68MP0004145_abnormal_muscle_electrophysio1.16693712
69MP0002063_abnormal_learning/memory/cond1.15235465
70MP0010368_abnormal_lymphatic_system1.13587074
71MP0000579_abnormal_nail_morphology1.08463065
72MP0008569_lethality_at_weaning1.02297061
73MP0001968_abnormal_touch/_nociception1.00356695
74MP0003942_abnormal_urinary_system0.98850994
75MP0003868_abnormal_feces_composition0.96202367
76MP0000613_abnormal_salivary_gland0.96026889
77MP0000026_abnormal_inner_ear0.95357522
78MP0002822_catalepsy0.95310995
79MP0009384_cardiac_valve_regurgitation0.95269514
80MP0000762_abnormal_tongue_morphology0.95182354
81MP0003937_abnormal_limbs/digits/tail_de0.93708992
82MP0009745_abnormal_behavioral_response0.92594107
83MP0002697_abnormal_eye_size0.89935644
84MP0003705_abnormal_hypodermis_morpholog0.88740929
85MP0000767_abnormal_smooth_muscle0.88604770
86MP0005220_abnormal_exocrine_pancreas0.84814939
87MP0006035_abnormal_mitochondrial_morpho0.84155667
88MP0000566_synostosis0.82551062
89MP0003938_abnormal_ear_development0.81335200
90MP0002108_abnormal_muscle_morphology0.79971087
91MP0009780_abnormal_chondrocyte_physiolo0.79785615
92MP0004742_abnormal_vestibular_system0.79728105
93MP0001879_abnormal_lymphatic_vessel0.79676529
94MP0000534_abnormal_ureter_morphology0.79180451
95MP0002653_abnormal_ependyma_morphology0.78970011
96MP0005620_abnormal_muscle_contractility0.78960915
97MP0003567_abnormal_fetal_cardiomyocyte0.78742174
98MP0003115_abnormal_respiratory_system0.77153366
99MP0002572_abnormal_emotion/affect_behav0.76997404
100MP0008260_abnormal_autophagy0.76846899
101MP0003634_abnormal_glial_cell0.76594773
102MP0002932_abnormal_joint_morphology0.75959711
103MP0000751_myopathy0.75586695
104MP0002736_abnormal_nociception_after0.74907864
105MP0000955_abnormal_spinal_cord0.74546272
106MP0004859_abnormal_synaptic_plasticity0.74517641
107MP0002092_abnormal_eye_morphology0.74244074
108MP0003091_abnormal_cell_migration0.73581049
109MP0001501_abnormal_sleep_pattern0.73274881
110MP0003385_abnormal_body_wall0.72571832
111MP0003890_abnormal_embryonic-extraembry0.72266916
112MP0004142_abnormal_muscle_tone0.72052363
113MP0004085_abnormal_heartbeat0.68591775
114MP0002277_abnormal_respiratory_mucosa0.68156945
115MP0003755_abnormal_palate_morphology0.68070358
116MP0003137_abnormal_impulse_conducting0.66682707
117MP0000049_abnormal_middle_ear0.64030011
118MP0000428_abnormal_craniofacial_morphol0.63500716
119MP0002009_preneoplasia0.62880141
120MP0003221_abnormal_cardiomyocyte_apopto0.62703535
121MP0000230_abnormal_systemic_arterial0.62690656
122MP0000013_abnormal_adipose_tissue0.61834579
123MP0002177_abnormal_outer_ear0.60621926
124MP0009697_abnormal_copulation0.60497609
125MP0004811_abnormal_neuron_physiology0.60308819
126MP0008004_abnormal_stomach_pH0.59447740
127MP0005332_abnormal_amino_acid0.59328468
128MP0003119_abnormal_digestive_system0.58436272
129MP0002557_abnormal_social/conspecific_i0.58069842
130MP0005623_abnormal_meninges_morphology0.57683721
131MP0001485_abnormal_pinna_reflex0.57148223
132MP0002751_abnormal_autonomic_nervous0.55288693
133MP0005386_behavior/neurological_phenoty0.54215259
134MP0004924_abnormal_behavior0.54215259
135MP0005187_abnormal_penis_morphology0.53957735
136MP0002115_abnormal_skeleton_extremities0.53666249
137MP0004043_abnormal_pH_regulation0.53084287
138MP0002089_abnormal_postnatal_growth/wei0.52314371
139MP0003698_abnormal_male_reproductive0.51061253
140MP0003935_abnormal_craniofacial_develop0.50612489
141MP0002269_muscular_atrophy0.49412411
142MP0002069_abnormal_eating/drinking_beha0.48928209
143MP0002066_abnormal_motor_capabilities/c0.48733821
144MP0004885_abnormal_endolymph0.47985580
145MP0002109_abnormal_limb_morphology0.47539120
146MP0003283_abnormal_digestive_organ0.46722668
147MP0002152_abnormal_brain_morphology0.46364620
148MP0001963_abnormal_hearing_physiology0.45905009
149MP0000163_abnormal_cartilage_morphology0.45266268
150MP0001614_abnormal_blood_vessel0.45168036
151MP0000537_abnormal_urethra_morphology0.44959570
152MP0001542_abnormal_bone_strength0.44935999
153MP0002127_abnormal_cardiovascular_syste0.44655394
154MP0008872_abnormal_physiological_respon0.44528755
155MP0002896_abnormal_bone_mineralization0.44017344
156MP0002233_abnormal_nose_morphology0.43198054
157MP0001661_extended_life_span0.43110792
158MP0003633_abnormal_nervous_system0.42808625
159MP0002128_abnormal_blood_circulation0.41529914
160MP0008995_early_reproductive_senescence0.41005576
161MP0002135_abnormal_kidney_morphology0.40109414
162MP0001958_emphysema0.39896084
163MP0002116_abnormal_craniofacial_bone0.39843327
164MP0009840_abnormal_foam_cell0.38619932
165MP0005390_skeleton_phenotype0.38328743
166MP0003936_abnormal_reproductive_system0.36194144
167MP0002282_abnormal_trachea_morphology0.33099524
168MP0002160_abnormal_reproductive_system0.32951220
169MP0002113_abnormal_skeleton_development0.32195767
170MP0002249_abnormal_larynx_morphology0.31885334
171MP0009643_abnormal_urine_homeostasis0.30579091
172MP0002938_white_spotting0.30125226
173MP0002136_abnormal_kidney_physiology0.30019101
174MP0000003_abnormal_adipose_tissue0.29698961

Predicted human phenotypes

RankGene SetZ-score
1Central scotoma (HP:0000603)8.25473967
2Aplasia involving bones of the extremities (HP:0009825)7.67547689
3Aplasia involving bones of the upper limbs (HP:0009823)7.67547689
4Aplasia of the phalanges of the hand (HP:0009802)7.67547689
5Abnormality of macular pigmentation (HP:0008002)7.43164911
6Severe visual impairment (HP:0001141)7.21519503
7Partial duplication of the phalanx of hand (HP:0009999)7.13527384
8Partial duplication of thumb phalanx (HP:0009944)7.00131386
9Glomerulonephritis (HP:0000099)6.93580939
10Abnormal rod and cone electroretinograms (HP:0008323)6.77761062
11Decreased central vision (HP:0007663)6.26188728
12Septo-optic dysplasia (HP:0100842)5.72136658
13Scotoma (HP:0000575)5.71706325
14Bony spicule pigmentary retinopathy (HP:0007737)5.71654223
15Alacrima (HP:0000522)5.58597211
16Recurrent corneal erosions (HP:0000495)5.55117233
17Nephritis (HP:0000123)5.41957902
18Increased corneal curvature (HP:0100692)5.29265582
19Keratoconus (HP:0000563)5.29265582
20Abnormality of incisor morphology (HP:0011063)5.12867437
21Conical tooth (HP:0000698)4.86574817
22Decreased lacrimation (HP:0000633)4.71609726
23Corneal erosion (HP:0200020)4.65773426
24Abnormal gallbladder physiology (HP:0012438)4.61711074
25Cholecystitis (HP:0001082)4.61711074
26Mixed hearing impairment (HP:0000410)4.32042579
27Aplasia/Hypoplasia of the fovea (HP:0008060)4.29704258
28Hypoplasia of the fovea (HP:0007750)4.29704258
29Epileptic encephalopathy (HP:0200134)4.09994920
30Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)4.03897737
31Albinism (HP:0001022)3.92779085
32Aplasia of the musculature (HP:0100854)3.87298532
33Protrusio acetabuli (HP:0003179)3.82088432
34Attenuation of retinal blood vessels (HP:0007843)3.82051061
35Premature rupture of membranes (HP:0001788)3.79943956
36Corneal dystrophy (HP:0001131)3.72749119
37Nasolacrimal duct obstruction (HP:0000579)3.63853363
38Duplication of thumb phalanx (HP:0009942)3.56996249
39Abnormality of the fovea (HP:0000493)3.51016262
40Febrile seizures (HP:0002373)3.49832463
41Absence seizures (HP:0002121)3.48203232
42Broad hallux (HP:0010055)3.41271142
43Xerostomia (HP:0000217)3.40693630
44Abnormality of the lacrimal duct (HP:0011481)3.39230925
45Abnormality of the nasolacrimal system (HP:0000614)3.38734084
46Nonprogressive disorder (HP:0003680)3.31766905
47Absent rod-and cone-mediated responses on ERG (HP:0007688)3.22934300
48Renal salt wasting (HP:0000127)3.18058631
49Pendular nystagmus (HP:0012043)3.13456694
50Aplasia/Hypoplasia of the macula (HP:0008059)3.12455521
51Hypoplasia of the iris (HP:0007676)3.09505515
52Abolished electroretinogram (ERG) (HP:0000550)3.04933538
53Abnormality of molar (HP:0011077)3.02991451
54Abnormality of molar morphology (HP:0011070)3.02991451
55Abnormality of permanent molar morphology (HP:0011071)3.00458660
56Abnormality of the dental root (HP:0006486)3.00458660
57Taurodontia (HP:0000679)3.00458660
58Aplasia/Hypoplasia affecting the retina (HP:0008061)2.99812996
59Abnormality of the musculature of the hand (HP:0001421)2.97597993
60Cupped ear (HP:0000378)2.95547189
61Broad toe (HP:0001837)2.90235604
62Hemiparesis (HP:0001269)2.88145115
63Vascular tortuosity (HP:0004948)2.87345649
64Absent septum pellucidum (HP:0001331)2.87143398
65Photophobia (HP:0000613)2.85007190
66Abnormality of the salivary glands (HP:0010286)2.84274789
67Pigmentary retinal degeneration (HP:0001146)2.79636810
68Concave nail (HP:0001598)2.76281627
69Preaxial foot polydactyly (HP:0001841)2.76034233
70Abnormal pupillary function (HP:0007686)2.75627782
71Optic nerve hypoplasia (HP:0000609)2.75084940
72Arterial tortuosity (HP:0005116)2.72603847
73Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.71125431
74Stage 5 chronic kidney disease (HP:0003774)2.70834352
75Dialeptic seizures (HP:0011146)2.70498863
76Chorioretinal atrophy (HP:0000533)2.70038074
77Abnormality of the dental pulp (HP:0006479)2.68681847
78Type II diabetes mellitus (HP:0005978)2.66849460
79Abnormality of the antihelix (HP:0009738)2.65737001
80Congenital sensorineural hearing impairment (HP:0008527)2.64429842
81Absent phalangeal crease (HP:0006109)2.62939863
82Progressive cerebellar ataxia (HP:0002073)2.61846021
83Hypoplasia of the ulna (HP:0003022)2.61581482
84Hyperextensible skin (HP:0000974)2.57184763
85Polar cataract (HP:0010696)2.56836038
86Hyperaldosteronism (HP:0000859)2.55897751
87Prolonged QT interval (HP:0001657)2.55491425
88Abnormality of abdominal situs (HP:0011620)2.54676413
89Abdominal situs inversus (HP:0003363)2.54676413
90Retinitis pigmentosa (HP:0000510)2.49251964
91Severe Myopia (HP:0011003)2.48684672
92Abnormality of the septum pellucidum (HP:0007375)2.45864734
93Abnormality of the incisor (HP:0000676)2.42325242
94Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)2.38493987
95Turricephaly (HP:0000262)2.38361574
96Congenital glaucoma (HP:0001087)2.35247122
97Hematuria (HP:0000790)2.31148321
98Cone-rod dystrophy (HP:0000548)2.30249319
99Absent radius (HP:0003974)2.28186758
100Congenital primary aphakia (HP:0007707)2.26618941
101Gait imbalance (HP:0002141)2.25664622
102Synostosis involving the elbow (HP:0003938)2.24276134
103Humeroradial synostosis (HP:0003041)2.24276134
104Hyperkalemia (HP:0002153)2.22989257
105Generalized hypopigmentation (HP:0007513)2.22502210
106Constricted visual fields (HP:0001133)2.22151744
107Aortic dissection (HP:0002647)2.21822583
108EEG with generalized epileptiform discharges (HP:0011198)2.19306530
109Heterochromia iridis (HP:0001100)2.19231794
110Hypoplasia of the radius (HP:0002984)2.18354562
111Dyschromatopsia (HP:0007641)2.17195533
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.16352140
113Mutism (HP:0002300)2.14970809
114Dysdiadochokinesis (HP:0002075)2.14263959
115Aplasia/Hypoplasia of the ulna (HP:0006495)2.14151349
116Abnormal finger flexion creases (HP:0006143)2.13241021
117Soft skin (HP:0000977)2.12708992
118Choroideremia (HP:0001139)2.12628636
119Absent forearm bone (HP:0003953)2.11712636
120Aplasia involving forearm bones (HP:0009822)2.11712636
121Coronal craniosynostosis (HP:0004440)2.10629577
122Epileptiform EEG discharges (HP:0011182)2.08977212
123Abnormality of the radial head (HP:0003995)2.06319131
124Abnormality of the middle phalanges of the hand (HP:0009833)2.05935380
125Shallow orbits (HP:0000586)2.03857017
126Unsteady gait (HP:0002317)2.02341733
127Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00697727
128Abnormality of alanine metabolism (HP:0010916)2.00697727
129Hyperalaninemia (HP:0003348)2.00697727
130Congenital stationary night blindness (HP:0007642)17.6297572
131Exostoses (HP:0100777)1.99768433
132Nephrogenic diabetes insipidus (HP:0009806)1.97252189
133Neonatal short-limb short stature (HP:0008921)1.97133489
134Cubitus valgus (HP:0002967)1.96260989
135Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95906117
136Aortic aneurysm (HP:0004942)1.95663915
137Abnormality of dentin (HP:0010299)1.95036390
138Overfolded helix (HP:0000396)1.93704735
139Enlarged penis (HP:0000040)1.91907803
140Medial flaring of the eyebrow (HP:0010747)1.90589695
141Exercise-induced myalgia (HP:0003738)1.90316181
142Astigmatism (HP:0000483)1.89408264
143Generalized tonic-clonic seizures (HP:0002069)1.88302517
144Bladder diverticulum (HP:0000015)1.87833872
145Neoplasm of the heart (HP:0100544)1.87032497
146Chorioretinal coloboma (HP:0000567)1.85217076
147Atrophic scars (HP:0001075)1.82796555
148Growth hormone deficiency (HP:0000824)1.82751837
149Abnormally folded helix (HP:0008544)1.81437824
150Broad metatarsal (HP:0001783)1.80601383
151Exercise-induced muscle cramps (HP:0003710)1.79353028
152Ventricular fibrillation (HP:0001663)1.79142494
153Hyponatremia (HP:0002902)1.78941331
154Poor coordination (HP:0002370)1.78093334
155Anterior segment dysgenesis (HP:0007700)1.76037523
156Fragile skin (HP:0001030)1.75325667
157Flat cornea (HP:0007720)1.75123808
158Hypodontia (HP:0000668)1.75000516
159Abnormality of the anterior chamber (HP:0000593)1.73366318
160Sex reversal (HP:0012245)1.72644635
161Abnormal sex determination (HP:0012244)1.72644635
162Depression (HP:0000716)1.72080914
163Aplasia/Hypoplasia of the earlobes (HP:0009906)1.72057344
164Decreased circulating renin level (HP:0003351)1.71495075
165Abnormality of the upper arm (HP:0001454)1.70806482
166Pterygium (HP:0001059)1.70531851
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.68827803
168Limited elbow extension (HP:0001377)1.68123263
169Ulnar bowing (HP:0003031)1.66710372
170Primary adrenal insufficiency (HP:0008207)1.66203342
171Osteoarthritis (HP:0002758)1.64992659
172Visual hallucinations (HP:0002367)1.63505301
173Mitral stenosis (HP:0001718)1.62368098
174Abnormality of the parietal bone (HP:0002696)1.61442359
175Abnormal EKG (HP:0003115)1.60192235
176Optic disc pallor (HP:0000543)1.59258480
177True hermaphroditism (HP:0010459)1.58566235
178Maternal diabetes (HP:0009800)1.57401579
179Macular degeneration (HP:0000608)1.56997470
180Aplasia/Hypoplasia of the lens (HP:0008063)1.54927563
181Myoglobinuria (HP:0002913)1.53922801
182Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.52904517
183Atrial fibrillation (HP:0005110)1.51355519
184Cholelithiasis (HP:0001081)1.48664946
185Abnormality of the sella turcica (HP:0002679)1.48322555
186Decreased electroretinogram (ERG) amplitude (HP:0000654)1.46762635
187Syncope (HP:0001279)1.46305846
188Posterior subcapsular cataract (HP:0007787)1.42219401
189Retinal dysplasia (HP:0007973)1.41279784
190Cerebellar dysplasia (HP:0007033)1.38232021
191Long toe (HP:0010511)1.36245241
192Hand muscle atrophy (HP:0009130)1.35981655
193Vaginal atresia (HP:0000148)1.35657717
194Action tremor (HP:0002345)1.34134442
195Primary atrial arrhythmia (HP:0001692)1.34101257

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.83403538
2PBK4.73187173
3MOS4.23411195
4TGFBR24.11941422
5NTRK13.96171108
6PAK63.58612207
7PRPF4B3.56958085
8TAOK23.54418923
9GRK73.53324920
10NME13.25871089
11GRK53.21302520
12RIPK12.99907402
13MYLK2.72041699
14STK38L2.66141660
15PDK22.59536678
16PHKG12.54288733
17PHKG22.54288733
18DYRK1A2.47982715
19CAMK2B2.45624691
20DDR22.41698284
21STK382.37007342
22INSRR2.25385384
23PDGFRA2.17684123
24TRPM72.15958162
25FGFR22.15933341
26MINK12.07782028
27EPHA32.07013490
28PINK12.04394740
29MAP3K42.03676681
30MARK11.92802837
31EPHB21.89252411
32MAP3K131.88495485
33STK101.78540511
34RET1.77391881
35TNK21.72637748
36CLK11.64418810
37MAP3K71.61630850
38PAK21.58920160
39FLT31.58686266
40CDK31.54482999
41ARAF1.50736855
42MAPKAPK51.46530307
43ADRBK11.45854400
44GRK11.38488172
45SIK11.37827450
46CAMK2D1.36966905
47FES1.32979648
48PTK21.29016674
49PRKAA11.25905998
50LATS11.19967327
51TIE11.15256093
52CDK81.14217805
53CAMK1D1.13284326
54EPHB11.11611601
55PAK41.11319912
56ADRBK21.09680860
57PNCK1.08068665
58FER1.07776693
59NEK91.07482325
60MKNK11.05284613
61MAPK151.01790400
62EPHA41.00429208
63CDK140.99622579
64AKT30.98140301
65MELK0.95760639
66PAK30.92132043
67DYRK1B0.90000545
68IRAK20.88542914
69SGK4940.87514951
70SGK2230.87514951
71TNIK0.87432734
72WNK30.87153129
73TESK10.86672753
74MAP3K90.86408020
75CAMK10.84773811
76NLK0.82710705
77MAP2K70.82049113
78RPS6KL10.78975302
79RPS6KC10.78975302
80PDK10.76801295
81CDK150.75838004
82BRD40.75198667
83MAP3K50.74962725
84EIF2AK20.73248783
85CSNK1G10.70907996
86PRKG10.70693646
87PKN10.70142768
88CDK180.69607209
89PRKCG0.69065285
90CAMK1G0.67691294
91TRIB30.66979696
92CDK11A0.66573195
93ABL20.66246611
94PLK30.66096213
95PIM20.66034072
96ROCK20.65510496
97ERBB30.65271918
98RPS6KA50.65205927
99CDK90.64674636
100PRKCE0.64184690
101LATS20.63882742
102RPS6KA60.63392499
103MTOR0.63369411
104MAPK100.60915408
105PRKCA0.60610876
106CAMK2A0.60114926
107MAP3K60.59450572
108NEK20.58972748
109ERN10.58940905
110PRKCZ0.58804360
111IRAK10.58695342
112PRKG20.57207551
113ERBB40.55849231
114TTK0.54979339
115PDGFRB0.54133189
116BRAF0.54026041
117CDK50.53050596
118CAMKK10.53015227
119FGFR40.51707444
120PRKACA0.50232629
121PRKD20.50222664
122PRKCB0.49616601
123MAP3K30.48227700
124RPS6KA30.48171382
125GSK3B0.46971094
126FGFR10.45621085
127MAPK40.45177084
128CHEK20.45044520
129PKN20.44973776
130AKT20.44816849
131LRRK20.44002822
132DAPK20.43561652
133PDPK10.42946377
134MARK20.41908838
135STK160.41517407
136KSR20.41149980
137INSR0.40866730
138CSNK1G30.39904843
139MAPK90.39844824
140CDK70.39595974
141RPS6KB20.38188836
142DAPK30.38188286
143ERBB20.38183353
144PRKACB0.37557926
145YES10.34552237
146RPS6KA20.33576174
147CAMKK20.33375329
148MAPK80.33151951
149MAPK140.32824598
150ROCK10.32692071
151BMX0.32641678
152PRKD10.32637182
153CCNB10.32157761
154MAP2K10.31879120
155MAPK10.31865545
156NEK60.31426182
157PRKAA20.29477338
158TTN0.29163400
159PRKACG0.29045321
160PRKD30.28908479
161MAPK70.28465459
162ICK0.27975894
163ILK0.27631390
164JAK10.27509337
165BCKDK0.27234964
166CDK10.26905782
167CSNK1E0.26202065
168TSSK60.25948542
169CSNK1A1L0.22200506
170JAK20.22171046

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.75596429
2Nitrogen metabolism_Homo sapiens_hsa009104.53339893
3GABAergic synapse_Homo sapiens_hsa047274.22106160
4Synaptic vesicle cycle_Homo sapiens_hsa047214.15358850
5ECM-receptor interaction_Homo sapiens_hsa045124.05227569
6Phototransduction_Homo sapiens_hsa047444.01133578
7Morphine addiction_Homo sapiens_hsa050323.65684919
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005323.52656153
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.35123874
10Circadian rhythm_Homo sapiens_hsa047103.05685254
11Fructose and mannose metabolism_Homo sapiens_hsa000512.69373765
12Steroid biosynthesis_Homo sapiens_hsa001002.64899920
13Circadian entrainment_Homo sapiens_hsa047132.46543470
14Small cell lung cancer_Homo sapiens_hsa052222.43920859
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.42528938
16Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.32019996
17Olfactory transduction_Homo sapiens_hsa047402.31091198
18Amoebiasis_Homo sapiens_hsa051462.22310487
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.18085559
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.17558570
21Vitamin B6 metabolism_Homo sapiens_hsa007502.12774573
22Melanoma_Homo sapiens_hsa052182.07266490
23Focal adhesion_Homo sapiens_hsa045102.03795666
24Renin secretion_Homo sapiens_hsa049242.01851470
25Insulin secretion_Homo sapiens_hsa049112.00177067
26Biosynthesis of amino acids_Homo sapiens_hsa012301.95292358
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.77671335
28Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.74629059
29Cardiac muscle contraction_Homo sapiens_hsa042601.73582745
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.71658431
31Salivary secretion_Homo sapiens_hsa049701.67726709
32Cholinergic synapse_Homo sapiens_hsa047251.66465406
33Glutamatergic synapse_Homo sapiens_hsa047241.66127324
34Collecting duct acid secretion_Homo sapiens_hsa049661.63586165
35Hedgehog signaling pathway_Homo sapiens_hsa043401.57718960
36Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.51714322
37TGF-beta signaling pathway_Homo sapiens_hsa043501.50134237
38Pentose phosphate pathway_Homo sapiens_hsa000301.48723479
39Oxytocin signaling pathway_Homo sapiens_hsa049211.48166490
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.45150053
41Taste transduction_Homo sapiens_hsa047421.43801993
42Serotonergic synapse_Homo sapiens_hsa047261.43505915
43Dilated cardiomyopathy_Homo sapiens_hsa054141.39138300
44PI3K-Akt signaling pathway_Homo sapiens_hsa041511.36683193
45Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.34962063
46Basal cell carcinoma_Homo sapiens_hsa052171.33584539
47Aldosterone synthesis and secretion_Homo sapiens_hsa049251.32293690
48Mineral absorption_Homo sapiens_hsa049781.28938786
49Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.25653009
50Glycosaminoglycan degradation_Homo sapiens_hsa005311.23463772
51cGMP-PKG signaling pathway_Homo sapiens_hsa040221.21532646
52Dopaminergic synapse_Homo sapiens_hsa047281.21320824
53Pathways in cancer_Homo sapiens_hsa052001.18999988
54Lysine degradation_Homo sapiens_hsa003101.17821892
55Galactose metabolism_Homo sapiens_hsa000521.16220079
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.14366307
57Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.12656246
58Sulfur metabolism_Homo sapiens_hsa009201.10749608
59Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09467249
60Wnt signaling pathway_Homo sapiens_hsa043101.07387155
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.07232659
62Regulation of actin cytoskeleton_Homo sapiens_hsa048101.06526813
63Calcium signaling pathway_Homo sapiens_hsa040201.01986488
64Carbon metabolism_Homo sapiens_hsa012001.00048833
65Tryptophan metabolism_Homo sapiens_hsa003800.99600509
66Rap1 signaling pathway_Homo sapiens_hsa040150.90525563
67Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86025777
68Vascular smooth muscle contraction_Homo sapiens_hsa042700.85204269
69Hippo signaling pathway_Homo sapiens_hsa043900.83800389
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79956091
71Type II diabetes mellitus_Homo sapiens_hsa049300.79350719
72Propanoate metabolism_Homo sapiens_hsa006400.77295672
73Gap junction_Homo sapiens_hsa045400.76047267
74Axon guidance_Homo sapiens_hsa043600.75262297
75Fatty acid degradation_Homo sapiens_hsa000710.73409158
76Proteoglycans in cancer_Homo sapiens_hsa052050.72016043
77Selenocompound metabolism_Homo sapiens_hsa004500.69022030
78Inositol phosphate metabolism_Homo sapiens_hsa005620.68463871
79Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67532698
802-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.67360755
81Prion diseases_Homo sapiens_hsa050200.65444447
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62709283
83HIF-1 signaling pathway_Homo sapiens_hsa040660.62434588
84cAMP signaling pathway_Homo sapiens_hsa040240.61286034
85Glutathione metabolism_Homo sapiens_hsa004800.60027140
86Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59453135
87Adherens junction_Homo sapiens_hsa045200.59411140
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57929107
89Alcoholism_Homo sapiens_hsa050340.57417100
90beta-Alanine metabolism_Homo sapiens_hsa004100.56946197
91Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.55069315
92mTOR signaling pathway_Homo sapiens_hsa041500.55035588
93Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.53230419
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52055597
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52009238
96Pyruvate metabolism_Homo sapiens_hsa006200.51157422
97Dorso-ventral axis formation_Homo sapiens_hsa043200.50580108
98Parkinsons disease_Homo sapiens_hsa050120.49765563
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49491878
100Vibrio cholerae infection_Homo sapiens_hsa051100.49093769
101Alzheimers disease_Homo sapiens_hsa050100.48613215
102Arginine and proline metabolism_Homo sapiens_hsa003300.48167730
103Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.46907287
104Purine metabolism_Homo sapiens_hsa002300.46422387
105Ovarian steroidogenesis_Homo sapiens_hsa049130.45501490
106Pancreatic secretion_Homo sapiens_hsa049720.45288667
107Histidine metabolism_Homo sapiens_hsa003400.45026330
108Vitamin digestion and absorption_Homo sapiens_hsa049770.42081854
109Arachidonic acid metabolism_Homo sapiens_hsa005900.41033688
110Sulfur relay system_Homo sapiens_hsa041220.40421053
111Bile secretion_Homo sapiens_hsa049760.40419957
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40055266
113Glucagon signaling pathway_Homo sapiens_hsa049220.39618502
114ABC transporters_Homo sapiens_hsa020100.38161100
115Oxidative phosphorylation_Homo sapiens_hsa001900.36976132
116Melanogenesis_Homo sapiens_hsa049160.34634244
117Long-term depression_Homo sapiens_hsa047300.33880737
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30365039
119GnRH signaling pathway_Homo sapiens_hsa049120.30166397
120Phospholipase D signaling pathway_Homo sapiens_hsa040720.30108900
121Complement and coagulation cascades_Homo sapiens_hsa046100.29950225
122AMPK signaling pathway_Homo sapiens_hsa041520.29565357
123Rheumatoid arthritis_Homo sapiens_hsa053230.29543594
124Metabolic pathways_Homo sapiens_hsa011000.29301076
125Phosphatidylinositol signaling system_Homo sapiens_hsa040700.28935407
126Fatty acid metabolism_Homo sapiens_hsa012120.27993183
127Huntingtons disease_Homo sapiens_hsa050160.27126995
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.27097731
129Regulation of autophagy_Homo sapiens_hsa041400.26646886
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25450339
131Nucleotide excision repair_Homo sapiens_hsa034200.25393417
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.25025956
133Sphingolipid metabolism_Homo sapiens_hsa006000.23899577
134Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22919991
135Protein digestion and absorption_Homo sapiens_hsa049740.22907078
136Gastric acid secretion_Homo sapiens_hsa049710.21427156
137Lysosome_Homo sapiens_hsa041420.21403417
138MAPK signaling pathway_Homo sapiens_hsa040100.20282373
139Steroid hormone biosynthesis_Homo sapiens_hsa001400.19585604
140Renal cell carcinoma_Homo sapiens_hsa052110.19433776
141alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.18269973
142Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.16832658
143Cocaine addiction_Homo sapiens_hsa050300.16356055
144SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15514518
145RNA degradation_Homo sapiens_hsa030180.13960602
146Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.13690252
147Amphetamine addiction_Homo sapiens_hsa050310.13646597
148Retinol metabolism_Homo sapiens_hsa008300.13034901
149Longevity regulating pathway - mammal_Homo sapiens_hsa042110.11767009
150Linoleic acid metabolism_Homo sapiens_hsa005910.11750899
151Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.11340077
152Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.10804245
153Ras signaling pathway_Homo sapiens_hsa040140.09917926
154Thyroid hormone synthesis_Homo sapiens_hsa049180.08661324
155Endocytosis_Homo sapiens_hsa041440.08637673
156Choline metabolism in cancer_Homo sapiens_hsa052310.06687386
157Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.05987712
158Fanconi anemia pathway_Homo sapiens_hsa034600.05629905

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