MGAT1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.95511408
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.95511408
3antigen processing and presentation of endogenous antigen (GO:0019883)5.43330791
4response to peptidoglycan (GO:0032494)4.32584060
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.01211970
6negative regulation of cell killing (GO:0031342)4.01211970
7negative regulation of interleukin-12 production (GO:0032695)3.96091212
8neutrophil activation involved in immune response (GO:0002283)3.89039099
9detection of other organism (GO:0098543)3.75107687
10alpha-linolenic acid metabolic process (GO:0036109)3.74945504
11positive regulation of gamma-delta T cell activation (GO:0046645)3.70277041
12fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69419041
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.69213257
14negative regulation of fibrinolysis (GO:0051918)3.67275877
15positive regulation of B cell differentiation (GO:0045579)3.63457416
16detection of bacterium (GO:0016045)3.59619688
17negative regulation of erythrocyte differentiation (GO:0045647)3.56231722
18regulation of interferon-beta biosynthetic process (GO:0045357)3.41886229
19triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.37306091
20lysine metabolic process (GO:0006553)3.35749899
21lysine catabolic process (GO:0006554)3.35749899
22detection of external biotic stimulus (GO:0098581)3.30532398
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28635618
24regulation of gamma-delta T cell differentiation (GO:0045586)3.27075254
25L-phenylalanine metabolic process (GO:0006558)3.26945978
26erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26945978
27peptidyl-glutamic acid carboxylation (GO:0017187)3.25659962
28protein carboxylation (GO:0018214)3.25659962
29valine metabolic process (GO:0006573)3.23599445
30detection of molecule of bacterial origin (GO:0032490)3.22511008
31response to muramyl dipeptide (GO:0032495)3.20605844
32glycosphingolipid catabolic process (GO:0046479)3.19988960
33glyoxylate metabolic process (GO:0046487)3.19789543
34L-phenylalanine catabolic process (GO:0006559)3.19713976
35erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.19713976
36antigen processing and presentation via MHC class Ib (GO:0002475)3.19470333
37regulation of mast cell degranulation (GO:0043304)3.19400688
38barbed-end actin filament capping (GO:0051016)3.19396989
39kynurenine metabolic process (GO:0070189)3.14658368
40pinocytosis (GO:0006907)3.13793540
41complement activation, classical pathway (GO:0006958)3.13412465
42protein localization to endosome (GO:0036010)3.12176413
43regulation of leukocyte degranulation (GO:0043300)3.11935706
44apoptotic cell clearance (GO:0043277)3.10996132
45regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10944538
46cellular extravasation (GO:0045123)3.05740518
47complement activation, alternative pathway (GO:0006957)3.02744462
48aromatic amino acid family catabolic process (GO:0009074)3.01886617
49regulation of B cell differentiation (GO:0045577)3.00043294
50complement activation (GO:0006956)2.98516304
51B cell receptor signaling pathway (GO:0050853)2.97308443
52regulation of fibrinolysis (GO:0051917)2.97070491
53regulation of B cell receptor signaling pathway (GO:0050855)2.96863427
54cellular response to thyroid hormone stimulus (GO:0097067)2.95321048
55regulation of myeloid leukocyte mediated immunity (GO:0002886)2.95122258
562-oxoglutarate metabolic process (GO:0006103)2.93967248
57NIK/NF-kappaB signaling (GO:0038061)2.93219130
58sulfur amino acid catabolic process (GO:0000098)2.92911129
59detection of biotic stimulus (GO:0009595)2.90832844
60regulation of gamma-delta T cell activation (GO:0046643)2.90223793
61positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89394890
62positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.88501799
63pentose-phosphate shunt (GO:0006098)2.87657064
64tryptophan catabolic process (GO:0006569)2.87597174
65indole-containing compound catabolic process (GO:0042436)2.87597174
66indolalkylamine catabolic process (GO:0046218)2.87597174
67type I interferon signaling pathway (GO:0060337)2.87344857
68cellular response to type I interferon (GO:0071357)2.87344857
69glycolipid catabolic process (GO:0019377)2.87194998
70plasma lipoprotein particle clearance (GO:0034381)2.86064116
71regulation of protein activation cascade (GO:2000257)2.86036063
72urea cycle (GO:0000050)2.85715500
73urea metabolic process (GO:0019627)2.85715500
74regulation of mast cell activation involved in immune response (GO:0033006)2.84893786
75interferon-gamma-mediated signaling pathway (GO:0060333)2.84310464
76positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.83783528
77regulation of T-helper 2 cell differentiation (GO:0045628)2.82289620
78regulation of cholesterol storage (GO:0010885)2.80376141
79regulation of fatty acid beta-oxidation (GO:0031998)2.79993960
80regulation of triglyceride catabolic process (GO:0010896)2.78540260
81oligosaccharide catabolic process (GO:0009313)2.77281214
82regulation of T cell tolerance induction (GO:0002664)2.77264045
83myeloid dendritic cell differentiation (GO:0043011)2.76768191
84tricarboxylic acid metabolic process (GO:0072350)2.75935963
85regulation of complement activation (GO:0030449)2.75604585
86regulation of cholesterol homeostasis (GO:2000188)2.75377791
87Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75098352
88germinal center formation (GO:0002467)2.74191918
89high-density lipoprotein particle remodeling (GO:0034375)2.73717248
90granulocyte activation (GO:0036230)2.73560400
91regulation of antigen processing and presentation (GO:0002577)2.73368189
92low-density lipoprotein particle clearance (GO:0034383)2.72793402
93immunoglobulin mediated immune response (GO:0016064)2.72740705
94bile acid biosynthetic process (GO:0006699)2.72157374
95negative regulation of phagocytosis (GO:0050765)2.70627093
96tryptophan metabolic process (GO:0006568)2.70542651
97positive regulation of interferon-alpha production (GO:0032727)2.69926050
98negative regulation of cytokine production involved in immune response (GO:0002719)2.68942498
99positive regulation of cellular amide metabolic process (GO:0034250)2.67807732
100cysteine metabolic process (GO:0006534)2.67635445
101ethanol oxidation (GO:0006069)2.66744084
102positive regulation of antigen processing and presentation (GO:0002579)2.64769456
103positive regulation of leukocyte degranulation (GO:0043302)2.63404238
104response to laminar fluid shear stress (GO:0034616)2.63110489
105T-helper 1 type immune response (GO:0042088)2.62700826
106response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62480375
107response to host immune response (GO:0052572)2.62480375
108negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.61741614
109leukocyte aggregation (GO:0070486)2.61606976
110NADPH regeneration (GO:0006740)2.60801629
111positive regulation by symbiont of host defense response (GO:0052509)2.60220831
112modulation by symbiont of host defense response (GO:0052031)2.60220831
113modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.60220831
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.60220831
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.60220831
116modulation by symbiont of host immune response (GO:0052553)2.60220831
117protein activation cascade (GO:0072376)2.59657138
118nitrogen cycle metabolic process (GO:0071941)2.59455291
119myeloid cell activation involved in immune response (GO:0002275)2.59308301
120macrophage activation (GO:0042116)2.57766151
121respiratory burst (GO:0045730)2.57121890
122phospholipid efflux (GO:0033700)2.55917493
123response to host (GO:0075136)2.55679426
124response to host defenses (GO:0052200)2.55679426
125response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.55679426
126regulation of tolerance induction (GO:0002643)2.55505814
127mannose metabolic process (GO:0006013)2.55419706
128positive regulation of mast cell activation (GO:0033005)2.55172395
129negative regulation of cholesterol transport (GO:0032375)2.54609114
130negative regulation of sterol transport (GO:0032372)2.54609114
131regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.54601970
132positive regulation of fatty acid beta-oxidation (GO:0032000)2.54081449
133neutrophil activation (GO:0042119)2.53318403
134adhesion of symbiont to host cell (GO:0044650)2.53274202
135virion attachment to host cell (GO:0019062)2.53274202
136regulation of interferon-alpha production (GO:0032647)2.52740488
137myeloid dendritic cell activation (GO:0001773)2.52203470
138amino-acid betaine metabolic process (GO:0006577)2.51389390
139angiogenesis involved in wound healing (GO:0060055)2.51363134
140reverse cholesterol transport (GO:0043691)2.51145782
141regulation of mononuclear cell migration (GO:0071675)2.50501854
142regulation of interleukin-12 biosynthetic process (GO:0045075)2.50423257
143positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.49796073
144negative regulation of leukocyte mediated immunity (GO:0002704)2.48576557
145macrophage activation involved in immune response (GO:0002281)2.48113170
146response to thyroid hormone (GO:0097066)2.47910227
147positive regulation of histone deacetylation (GO:0031065)2.47885891
148fatty acid beta-oxidation (GO:0006635)2.47621779
149positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.47457784
150positive regulation of type 2 immune response (GO:0002830)2.47324334
151positive regulation of triglyceride metabolic process (GO:0090208)2.47195921
152oxaloacetate metabolic process (GO:0006107)2.46319764
153regulation of type 2 immune response (GO:0002828)2.46184123
154negative regulation of innate immune response (GO:0045824)2.46048181
155protein-lipid complex remodeling (GO:0034368)2.46027912
156macromolecular complex remodeling (GO:0034367)2.46027912
157plasma lipoprotein particle remodeling (GO:0034369)2.46027912
158killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.45760502
159disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.45760502
160positive regulation of Cdc42 GTPase activity (GO:0043089)2.45013863
161regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.44976139
162phospholipid homeostasis (GO:0055091)2.44869752
163positive regulation of blood coagulation (GO:0030194)2.44414496
164positive regulation of hemostasis (GO:1900048)2.44414496
165regulation of type I interferon-mediated signaling pathway (GO:0060338)2.44096890
166cellular modified amino acid catabolic process (GO:0042219)2.44093543
167defense response to protozoan (GO:0042832)2.43970653
168response to type I interferon (GO:0034340)2.43848224
169B cell mediated immunity (GO:0019724)2.43731093
170N-acetylneuraminate metabolic process (GO:0006054)2.42982812
171regulation of plasminogen activation (GO:0010755)2.42734656
172positive regulation of natural killer cell differentiation (GO:0032825)2.42727792
173positive regulation of triglyceride biosynthetic process (GO:0010867)2.42359878
174positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.42288076
175ceramide catabolic process (GO:0046514)2.42103118
176homocysteine metabolic process (GO:0050667)2.41717418
177positive regulation of coagulation (GO:0050820)2.41652659
178positive regulation of mast cell activation involved in immune response (GO:0033008)2.41610707
179positive regulation of mast cell degranulation (GO:0043306)2.41610707
180positive thymic T cell selection (GO:0045059)2.41365926
181regulation of monocyte chemotaxis (GO:0090025)2.41341131
182regulation of superoxide anion generation (GO:0032928)2.40693245

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.98048784
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.01152238
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.62736421
4* RXR_22158963_ChIP-Seq_LIVER_Mouse3.45078088
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.30164541
6MYC_22102868_ChIP-Seq_BL_Human2.65828376
7LXR_22158963_ChIP-Seq_LIVER_Mouse2.64489032
8VDR_21846776_ChIP-Seq_THP-1_Human2.55861731
9* IRF8_21731497_ChIP-ChIP_J774_Mouse2.50268545
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47066692
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.46842815
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.44410808
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.25610820
14SCL_19346495_ChIP-Seq_HPC-7_Human2.25363966
15TP63_17297297_ChIP-ChIP_HaCaT_Human2.23953632
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.22205117
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.20789831
18* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.17777014
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.15490722
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.13803756
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13759376
22SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.13492786
23MYB_21317192_ChIP-Seq_ERMYB_Mouse2.10491853
24RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.09256090
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.03632645
26MAF_26560356_Chip-Seq_TH1_Human1.98774735
27BP1_19119308_ChIP-ChIP_Hs578T_Human1.98511154
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95287837
29GATA1_22025678_ChIP-Seq_K562_Human1.92222288
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.90174377
31CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.88115846
32* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.84930090
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.83860037
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.83066606
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82972961
36* VDR_24763502_ChIP-Seq_THP-1_Human1.79491455
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79029095
38* TCF7_22412390_ChIP-Seq_EML_Mouse1.78353952
39RARG_19884340_ChIP-ChIP_MEFs_Mouse1.77337102
40CLOCK_20551151_ChIP-Seq_293T_Human1.76635008
41LXR_22292898_ChIP-Seq_THP-1_Human1.75956941
42* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75422731
43VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.72127847
44UTX_26944678_Chip-Seq_JUKART_Human1.70685209
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.61676473
46* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.61498935
47EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.55635201
48* MYB_26560356_Chip-Seq_TH2_Human1.53906407
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.53243576
50* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52994361
51RUNX_20019798_ChIP-Seq_JUKART_Human1.52771608
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.49620149
53MYB_26560356_Chip-Seq_TH1_Human1.47052265
54* KDM2B_26808549_Chip-Seq_DND41_Human1.45413864
55CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.43528056
56SPI1_23127762_ChIP-Seq_K562_Human1.41394999
57* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.41269740
58* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40714365
59KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40697438
60* SPI1_23547873_ChIP-Seq_NB4_Human1.40632582
61NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.39963823
62VDR_24787735_ChIP-Seq_THP-1_Human1.39922063
63STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37520506
64* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.33417277
65* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.32685077
66* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32636943
67ESR2_21235772_ChIP-Seq_MCF-7_Human1.30863716
68ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30237388
69TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.30107841
70FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28397365
71PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25108626
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24975614
73GATA1_19941827_ChIP-Seq_MEL_Mouse1.23241829
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21433376
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.19534991
76* KDM2B_26808549_Chip-Seq_K562_Human1.19364825
77MAF_26560356_Chip-Seq_TH2_Human1.18885601
78RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16556597
79CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15540259
80GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15224623
81* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.14704624
82STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.14634519
83* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.14214130
84* KDM2B_26808549_Chip-Seq_JURKAT_Human1.13517253
85KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.13331718
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.12263349
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.11926196
88GATA1_19941826_ChIP-Seq_K562_Human1.11144379
89SA1_27219007_Chip-Seq_ERYTHROID_Human1.09924044
90RACK7_27058665_Chip-Seq_MCF-7_Human1.09642380
91GATA2_21666600_ChIP-Seq_HMVEC_Human1.09176023
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08051788
93CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07608455
94CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07497413
95SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06775971
96Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06648922
97* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.03515257
98TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02313349
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01391114
100GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01081615
101HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00963979
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00430009
103P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00243250
104BCL6_27268052_Chip-Seq_Bcells_Human1.00021728
105* LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99939429
106TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.99197925
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98970998
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.98590996
109NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97977740
110NCOR1_26117541_ChIP-Seq_K562_Human0.97276081
111* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96544393
112* GATA3_27048872_Chip-Seq_THYMUS_Human0.96357258
113* PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95653878
114* PU_27001747_Chip-Seq_BMDM_Mouse0.95521760
115GATA2_19941826_ChIP-Seq_K562_Human0.95015353
116CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93954977
117PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91230169
118BCOR_27268052_Chip-Seq_Bcells_Human0.89282073
119FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.88722858
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.87687177
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.85292396
122ATF3_27146783_Chip-Seq_COLON_Human0.84280200
123TBX20_22328084_ChIP-Seq_HEART_Mouse0.83601090

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis3.51790935
2MP0002139_abnormal_hepatobiliary_system3.24172178
3MP0009840_abnormal_foam_cell2.85149970
4MP0001835_abnormal_antigen_presentation2.79134863
5MP0003191_abnormal_cellular_cholesterol2.64451081
6MP0005365_abnormal_bile_salt2.59153955
7MP0003705_abnormal_hypodermis_morpholog2.52843007
8MP0005085_abnormal_gallbladder_physiolo2.33386209
9MP0008438_abnormal_cutaneous_collagen2.26314096
10MP0003303_peritoneal_inflammation2.25870674
11MP0000685_abnormal_immune_system2.20847006
12MP0005451_abnormal_body_composition2.20787700
13MP0003436_decreased_susceptibility_to2.19141361
14MP0003300_gastrointestinal_ulcer2.19086886
15MP0005058_abnormal_lysosome_morphology2.13568347
16MP0003252_abnormal_bile_duct1.96790558
17MP0009785_altered_susceptibility_to1.89778321
18MP0001800_abnormal_humoral_immune1.87776125
19MP0001790_abnormal_immune_system1.87402464
20MP0005387_immune_system_phenotype1.87402464
21MP0005464_abnormal_platelet_physiology1.86595941
22MP0008875_abnormal_xenobiotic_pharmacok1.84249003
23MP0006054_spinal_hemorrhage1.77985765
24MP0010329_abnormal_lipoprotein_level1.77569812
25MP0008260_abnormal_autophagy1.72158654
26MP0005025_abnormal_response_to1.71675420
27MP0002419_abnormal_innate_immunity1.70576914
28MP0002452_abnormal_antigen_presenting1.69432593
29MP0003828_pulmonary_edema1.66421043
30MP0010368_abnormal_lymphatic_system1.65898828
31MP0003724_increased_susceptibility_to1.64683890
32MP0002396_abnormal_hematopoietic_system1.63460395
33MP0005000_abnormal_immune_tolerance1.58831045
34MP0002166_altered_tumor_susceptibility1.56748123
35MP0005083_abnormal_biliary_tract1.56187842
36MP0002723_abnormal_immune_serum1.52718944
37MP0000609_abnormal_liver_physiology1.52175645
38MP0003279_aneurysm1.46743932
39MP0002420_abnormal_adaptive_immunity1.45881217
40MP0001819_abnormal_immune_cell1.44096720
41MP0006082_CNS_inflammation1.44079084
42MP0005671_abnormal_response_to1.42839014
43MP0003172_abnormal_lysosome_physiology1.42269193
44MP0008469_abnormal_protein_level1.39359623
45MP0002138_abnormal_hepatobiliary_system1.37452468
46MP0003448_altered_tumor_morphology1.36777141
47MP0004947_skin_inflammation1.35401346
48MP0001666_abnormal_nutrient_absorption1.35392344
49MP0001845_abnormal_inflammatory_respons1.35050317
50MP0005332_abnormal_amino_acid1.32923818
51MP0003453_abnormal_keratinocyte_physiol1.32682794
52MP0003566_abnormal_cell_adhesion1.32128686
53MP0000689_abnormal_spleen_morphology1.31865334
54MP0001533_abnormal_skeleton_physiology1.31076776
55MP0001958_emphysema1.29073653
56MP0002398_abnormal_bone_marrow1.28479297
57MP0000465_gastrointestinal_hemorrhage1.27361044
58MP0010155_abnormal_intestine_physiology1.25728647
59MP0002148_abnormal_hypersensitivity_rea1.25218895
60MP0000716_abnormal_immune_system1.24890550
61MP0005319_abnormal_enzyme/_coenzyme1.24605325
62MP0001853_heart_inflammation1.21379143
63MP0009643_abnormal_urine_homeostasis1.21296783
64MP0003806_abnormal_nucleotide_metabolis1.19752131
65MP0002405_respiratory_system_inflammati1.19734348
66MP0009278_abnormal_bone_marrow1.16723650
67MP0005257_abnormal_intraocular_pressure1.16222093
68MP0002877_abnormal_melanocyte_morpholog1.16028140
69MP0001879_abnormal_lymphatic_vessel1.15937438
70MP0003690_abnormal_glial_cell1.15717244
71MP0005164_abnormal_response_to1.15302227
72MP0002254_reproductive_system_inflammat1.15177952
73MP0005023_abnormal_wound_healing1.14910387
74MP0005584_abnormal_enzyme/coenzyme_acti1.14822537
75MP0002722_abnormal_immune_system1.14571899
76MP0002933_joint_inflammation1.13765495
77MP0005310_abnormal_salivary_gland1.13387722
78MP0001849_ear_inflammation1.13209577
79MP0005397_hematopoietic_system_phenotyp1.13021116
80MP0001545_abnormal_hematopoietic_system1.13021116
81MP0005390_skeleton_phenotype1.12337633
82* MP0002429_abnormal_blood_cell1.10919961
83MP0004510_myositis1.10129040
84MP0000598_abnormal_liver_morphology1.10071409
85MP0004808_abnormal_hematopoietic_stem1.09838814
86MP0004130_abnormal_muscle_cell1.09586762
87MP0010352_gastrointestinal_tract_polyps1.08870889
88MP0002118_abnormal_lipid_homeostasis1.08085525
89MP0003329_amyloid_beta_deposits1.08010907
90MP0000343_altered_response_to1.07276204
91MP0001542_abnormal_bone_strength1.06691926
92MP0009764_decreased_sensitivity_to1.05117220
93MP0004883_abnormal_blood_vessel1.04658819
94MP0003183_abnormal_peptide_metabolism1.03769022
95MP0001851_eye_inflammation1.03679823
96MP0001873_stomach_inflammation1.03630619
97MP0003656_abnormal_erythrocyte_physiolo1.03052263
98MP0003075_altered_response_to1.02749498
99MP0008004_abnormal_stomach_pH1.02264478
100MP0009333_abnormal_splenocyte_physiolog1.01324188
101MP0003763_abnormal_thymus_physiology1.00287855
102MP0009763_increased_sensitivity_to0.99904870
103MP0005670_abnormal_white_adipose0.95660582
104MP0005076_abnormal_cell_differentiation0.94471851
105MP0002006_tumorigenesis0.93582312
106MP0004858_abnormal_nervous_system0.93489295
107MP0002136_abnormal_kidney_physiology0.93038413
108MP0005275_abnormal_skin_tensile0.91888308
109MP0000249_abnormal_blood_vessel0.91861775
110MP0003795_abnormal_bone_structure0.89873538
111MP0000604_amyloidosis0.88673027
112MP0005165_increased_susceptibility_to0.82929260
113MP0000858_altered_metastatic_potential0.81744492
114MP0002998_abnormal_bone_remodeling0.79911444
115MP0000767_abnormal_smooth_muscle0.79107453
116MP0005666_abnormal_adipose_tissue0.78788448
117MP0005166_decreased_susceptibility_to0.77972937
118MP0003195_calcinosis0.75685741
119MP0003091_abnormal_cell_migration0.74930413
120MP0002928_abnormal_bile_duct0.74444606
121MP0003186_abnormal_redox_activity0.73975710
122MP0004019_abnormal_vitamin_homeostasis0.73853014
123MP0004185_abnormal_adipocyte_glucose0.71576979
124MP0003866_abnormal_defecation0.71542374
125MP0001663_abnormal_digestive_system0.69294531
126MP0000490_abnormal_crypts_of0.68796974
127MP0000920_abnormal_myelination0.68656322
128MP0005167_abnormal_blood-brain_barrier0.62780909
129MP0008874_decreased_physiological_sensi0.62635649
130MP0002060_abnormal_skin_morphology0.60509218

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of liposaccharide metabolism (HP:0010968)5.33433321
2Abnormality of glycosphingolipid metabolism (HP:0004343)5.33433321
3Abnormality of glycolipid metabolism (HP:0010969)5.33433321
4Deep venous thrombosis (HP:0002625)3.96919776
5Systemic lupus erythematosus (HP:0002725)3.39262963
6Complement deficiency (HP:0004431)3.26440580
7Xanthomatosis (HP:0000991)3.22258468
8Cellulitis (HP:0100658)3.09043373
9Orchitis (HP:0100796)3.08177877
10Elevated erythrocyte sedimentation rate (HP:0003565)3.06238605
11Colitis (HP:0002583)3.01423047
12Mediastinal lymphadenopathy (HP:0100721)2.92695717
13Chronic otitis media (HP:0000389)2.90349828
14Interstitial pulmonary disease (HP:0006530)2.89919421
15Protrusio acetabuli (HP:0003179)2.88026032
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.87867185
17Abnormality of monocarboxylic acid metabolism (HP:0010996)2.78047298
18Recurrent gram-negative bacterial infections (HP:0005420)2.75260535
19Cerebral aneurysm (HP:0004944)2.72660475
20Abnormality of the common coagulation pathway (HP:0010990)2.71969106
21Spontaneous hematomas (HP:0007420)2.69546182
22Abnormality of the nasal mucosa (HP:0000433)2.67251315
23Abnormality of complement system (HP:0005339)2.64660046
24Peritonitis (HP:0002586)2.64191100
25Recurrent bronchitis (HP:0002837)2.61630626
26Joint hemorrhage (HP:0005261)2.60961000
27Mitral stenosis (HP:0001718)2.59893000
28Eczematoid dermatitis (HP:0000976)2.59560942
29Gingivitis (HP:0000230)2.59520902
30Retrobulbar optic neuritis (HP:0100654)2.59520552
31Optic neuritis (HP:0100653)2.59520552
32Recurrent bacterial skin infections (HP:0005406)2.59094593
33Recurrent abscess formation (HP:0002722)2.57195666
34Obstructive lung disease (HP:0006536)2.56524018
35Chronic obstructive pulmonary disease (HP:0006510)2.56524018
36Dysostosis multiplex (HP:0000943)2.54851127
37Vacuolated lymphocytes (HP:0001922)2.54227472
38Recurrent viral infections (HP:0004429)2.54105839
39Glomerulonephritis (HP:0000099)2.52525507
40Purpura (HP:0000979)2.52467230
41Myocardial infarction (HP:0001658)2.52174187
42Hematochezia (HP:0002573)2.50406508
43Myositis (HP:0100614)2.49919143
44Gastrointestinal inflammation (HP:0004386)2.48257859
45Agammaglobulinemia (HP:0004432)2.47613741
46Inflammation of the large intestine (HP:0002037)2.45882276
47Autoimmune thrombocytopenia (HP:0001973)2.44617631
48Mucopolysacchariduria (HP:0008155)2.42746804
49Urinary glycosaminoglycan excretion (HP:0003541)2.42746804
50Verrucae (HP:0200043)2.42589600
51Papilloma (HP:0012740)2.42589600
52IgM deficiency (HP:0002850)2.40965455
53Thrombocytosis (HP:0001894)2.40196980
54Increased cerebral lipofuscin (HP:0011813)2.39782640
55Hyperlipoproteinemia (HP:0010980)2.39597795
56Nasal polyposis (HP:0100582)2.36421915
57Intrahepatic cholestasis (HP:0001406)2.34917489
58Neurofibrillary tangles (HP:0002185)2.32082016
59Ketosis (HP:0001946)2.27182171
60Stomatitis (HP:0010280)2.26671149
61Abnormality of glutamine family amino acid metabolism (HP:0010902)2.26409011
62Increased IgE level (HP:0003212)2.24840105
63Disinhibition (HP:0000734)2.23320255
64Hyperammonemia (HP:0001987)2.23174655
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.20147816
66Abnormality of polysaccharide metabolism (HP:0011012)2.20147816
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.20147816
68Impaired platelet aggregation (HP:0003540)2.19753904
69Abnormal platelet function (HP:0011869)2.19753904
70Gastrointestinal infarctions (HP:0005244)2.19616772
71Abnormality of fatty-acid metabolism (HP:0004359)2.18685610
72Pulmonary infiltrates (HP:0002113)2.18464698
73Aortic aneurysm (HP:0004942)2.17937764
74Hepatosplenomegaly (HP:0001433)2.17443033
75Spondylolisthesis (HP:0003302)2.16367776
76Polycythemia (HP:0001901)2.16067322
77Nonimmune hydrops fetalis (HP:0001790)2.13828903
78Abnormality of macrophages (HP:0004311)2.13606063
79Malnutrition (HP:0004395)2.11638119
80Epistaxis (HP:0000421)2.11552781
81Gingival bleeding (HP:0000225)2.10912191
82Hypobetalipoproteinemia (HP:0003563)2.10474543
83Nuclear cataract (HP:0100018)2.09900451
84Urticaria (HP:0001025)2.09561210
85Asymmetric septal hypertrophy (HP:0001670)2.09424154
86Gastrointestinal stroma tumor (HP:0100723)2.09000204
87Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.08884789
88Abnormality of the intrinsic pathway (HP:0010989)2.07821698
89Vasculitis (HP:0002633)2.07737024
90Prolonged partial thromboplastin time (HP:0003645)2.07618409
91Nephritis (HP:0000123)2.07363532
92Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.06296778
93Emphysema (HP:0002097)2.04625969
94Upper motor neuron abnormality (HP:0002127)2.01501936
95Petechiae (HP:0000967)2.00373993
96Aortic dissection (HP:0002647)1.99900444
97Recurrent skin infections (HP:0001581)1.99722904
98Meningitis (HP:0001287)1.99220020
99Increased neuronal autofluorescent lipopigment (HP:0002074)1.98950042
100Hemoptysis (HP:0002105)1.97529377
101Hypoalphalipoproteinemia (HP:0003233)1.96816266
102Recurrent fungal infections (HP:0002841)1.96212098
103Thin bony cortex (HP:0002753)1.94100310
104Hypoglycemic coma (HP:0001325)1.92898773
105Thoracic kyphosis (HP:0002942)1.92387907
106Chronic mucocutaneous candidiasis (HP:0002728)1.91912381
107Recurrent cutaneous fungal infections (HP:0011370)1.91912381
108Loss of speech (HP:0002371)1.91628838
109Neuronal loss in central nervous system (HP:0002529)1.91094359
110Dilatation of the ascending aorta (HP:0005111)1.90829447
111Esophageal varix (HP:0002040)1.90757340
112Abnormal platelet volume (HP:0011876)1.90121531
113Progressive neurologic deterioration (HP:0002344)1.89924895
114Pustule (HP:0200039)1.89901332
115Axonal loss (HP:0003447)1.89800405
116Increased serum ferritin (HP:0003281)1.89488156
117Cerebral inclusion bodies (HP:0100314)1.89371459
118Hypolipoproteinemia (HP:0010981)1.89025935
119Ectopia lentis (HP:0001083)1.88773070
120Abnormality of iron homeostasis (HP:0011031)1.88484532
121Keratoconjunctivitis sicca (HP:0001097)1.88093219
122Vertebral compression fractures (HP:0002953)1.86590574
123Amyloidosis (HP:0011034)1.86157307
124Osteomyelitis (HP:0002754)1.85980056
125Thrombophlebitis (HP:0004418)1.85725669
126Polygenic inheritance (HP:0010982)1.84790017
127Cervical subluxation (HP:0003308)1.84762499
128Pulmonary embolism (HP:0002204)1.84186846
129Premature rupture of membranes (HP:0001788)1.84160019
130Bone pain (HP:0002653)1.83632737
131Joint stiffness (HP:0001387)1.83569579
132Menorrhagia (HP:0000132)1.83117427
133Ketoacidosis (HP:0001993)1.81463142
134Distal lower limb muscle weakness (HP:0009053)1.81324234
135Abnormality of the vasculature of the conjunctiva (HP:0008054)1.80910373
136Premature loss of primary teeth (HP:0006323)1.79946931
137Hypercholesterolemia (HP:0003124)1.79846146
138Restrictive lung disease (HP:0002091)1.78753582
139Abnormality of purine metabolism (HP:0004352)1.78577176
140Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.78500851
141Pathologic fracture (HP:0002756)1.78201495
142Increased mean platelet volume (HP:0011877)1.78034761
143Lymphangioma (HP:0100764)1.77995657
144Mitral valve prolapse (HP:0001634)1.77665400
145Mutism (HP:0002300)1.77102931
146Hemorrhage of the eye (HP:0011885)1.76978492
147Abnormality of the peritoneum (HP:0002585)1.76783831
148Diminished motivation (HP:0000745)1.75790247
149Apathy (HP:0000741)1.75215195

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.77036101
2TRIB34.03183197
3MAP4K13.54247348
4PKN23.43610354
5PRPF4B3.19135404
6MAP3K102.87605471
7EEF2K2.71389985
8TGFBR22.42066605
9FLT32.33575874
10KIT2.31750045
11TYK22.31524526
12TBK12.25128780
13BCKDK2.11399781
14FGFR42.07090767
15CSF1R2.02411135
16KDR1.87019846
17BLK1.84020292
18TAOK21.80563152
19LRRK21.76984284
20SIK11.74264119
21TTN1.67598383
22MAP2K31.67013227
23ZAP701.53662480
24PTK61.52388339
25TAOK31.48700154
26JAK11.48337448
27BTK1.45932736
28JAK31.44935052
29GRK61.44473546
30CDC42BPA1.42623624
31DDR21.42485369
32STK101.39990147
33SMG11.39873572
34EPHB11.39326630
35RIPK11.36766264
36SCYL21.34208659
37FGR1.31902956
38NME21.29546263
39GRK71.26456212
40TIE11.22996881
41MOS1.20186729
42SYK1.19105218
43PRKD21.14832797
44TESK11.12933484
45NEK91.10073877
46CSK1.07924453
47IKBKE1.06041615
48RPS6KA41.03878319
49ICK1.03746199
50HCK1.00280852
51TGFBR10.97616668
52MAP3K110.97086057
53KSR20.93645460
54ARAF0.90760237
55MAPK110.88251371
56TNK20.86814257
57ITK0.86673574
58PAK40.86055505
59PIM20.85580404
60JAK20.85456024
61MAPKAPK30.85003663
62PDGFRA0.83144057
63MARK20.83036800
64FES0.82908543
65MAP3K130.81985568
66TEC0.81213663
67MAP3K70.78752338
68IRAK40.77612065
69RPS6KA20.77170273
70MAP3K60.75900578
71FGFR30.75564682
72SIK20.74650658
73MAPK70.73472212
74LCK0.71314638
75LYN0.70896079
76MATK0.68634278
77MAPK120.68338496
78SIK30.67147865
79CAMK1D0.66815796
80IKBKB0.66524506
81MAP3K140.64346586
82MAP3K30.61871171
83CLK10.61228067
84TXK0.59611781
85CDK120.57614848
86MARK30.57135987
87PIM10.56696432
88PIK3CG0.56586030
89IRAK20.56568886
90PAK20.55409826
91HIPK20.54517170
92TAOK10.54058512
93MAP3K80.52436143
94IRAK30.52390590
95RET0.52135434
96PRKCH0.50999451
97MAPK40.50875085
98ILK0.49423511
99TRPM70.48737113
100TESK20.46992821
101MAP3K50.46877678
102CDK40.46582441
103BMX0.45667938
104MAPKAPK20.44646522
105CDK60.42515050
106MYLK0.42051741
107RIPK40.42005237
108PDK10.41995029
109MAP3K10.41028261
110DYRK1B0.40730837
111IRAK10.40635694
112BMPR20.39956048
113RPS6KA60.38546246
114FYN0.38176002
115RPS6KB20.37329980
116EPHA30.36770692
117PRKG20.36554114
118CAMKK10.36124229
119EGFR0.35154224
120PTK20.34848834
121PRKD10.33634191
122PDPK10.33500594
123PDGFRB0.31892929
124MTOR0.30814571
125ABL20.30808643
126RPS6KC10.30479640
127RPS6KL10.30479640
128CHUK0.30236544
129ABL10.30208904

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001202.91460604
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65212596
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.55762562
4Staphylococcus aureus infection_Homo sapiens_hsa051502.55301979
5Nitrogen metabolism_Homo sapiens_hsa009102.37598688
6Complement and coagulation cascades_Homo sapiens_hsa046102.36737280
7Fatty acid degradation_Homo sapiens_hsa000712.24780653
8Caffeine metabolism_Homo sapiens_hsa002322.10763621
9Allograft rejection_Homo sapiens_hsa053302.08839089
10Graft-versus-host disease_Homo sapiens_hsa053321.93870593
11Tryptophan metabolism_Homo sapiens_hsa003801.93371374
12Arginine biosynthesis_Homo sapiens_hsa002201.91455388
13Pentose and glucuronate interconversions_Homo sapiens_hsa000401.90039017
14Autoimmune thyroid disease_Homo sapiens_hsa053201.85592865
15B cell receptor signaling pathway_Homo sapiens_hsa046621.85499106
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.78446929
17Glycosaminoglycan degradation_Homo sapiens_hsa005311.73160140
18Primary immunodeficiency_Homo sapiens_hsa053401.72833207
19PPAR signaling pathway_Homo sapiens_hsa033201.70670492
20Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65381429
21Asthma_Homo sapiens_hsa053101.63996657
22Rheumatoid arthritis_Homo sapiens_hsa053231.63239747
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.62467668
24Other glycan degradation_Homo sapiens_hsa005111.56099811
25Leishmaniasis_Homo sapiens_hsa051401.55247889
26Phagosome_Homo sapiens_hsa041451.54572462
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.48499379
28Fatty acid metabolism_Homo sapiens_hsa012121.39795065
29Osteoclast differentiation_Homo sapiens_hsa043801.36052202
30Peroxisome_Homo sapiens_hsa041461.35156297
31Propanoate metabolism_Homo sapiens_hsa006401.30351881
32Type I diabetes mellitus_Homo sapiens_hsa049401.29888846
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.29643615
34Selenocompound metabolism_Homo sapiens_hsa004501.27559934
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.25417929
36Salmonella infection_Homo sapiens_hsa051321.24092798
37Starch and sucrose metabolism_Homo sapiens_hsa005001.20983639
38Lysosome_Homo sapiens_hsa041421.19565490
39Antigen processing and presentation_Homo sapiens_hsa046121.18978867
40Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.17050734
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.15392871
42Prion diseases_Homo sapiens_hsa050201.15234624
43Chemokine signaling pathway_Homo sapiens_hsa040621.12465480
44Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11954256
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.09720217
46Pentose phosphate pathway_Homo sapiens_hsa000301.06686412
47Carbon metabolism_Homo sapiens_hsa012001.06358191
48beta-Alanine metabolism_Homo sapiens_hsa004101.06122221
49ABC transporters_Homo sapiens_hsa020101.05591995
50Toll-like receptor signaling pathway_Homo sapiens_hsa046201.03772353
51Sulfur relay system_Homo sapiens_hsa041221.02699976
52Bladder cancer_Homo sapiens_hsa052191.02142474
53Malaria_Homo sapiens_hsa051441.01309842
54Pertussis_Homo sapiens_hsa051331.01286112
55Bile secretion_Homo sapiens_hsa049760.99777367
56Intestinal immune network for IgA production_Homo sapiens_hsa046720.96587624
57Toxoplasmosis_Homo sapiens_hsa051450.95049277
58T cell receptor signaling pathway_Homo sapiens_hsa046600.93233474
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.93006876
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.92484022
61Insulin resistance_Homo sapiens_hsa049310.90883246
62Lysine degradation_Homo sapiens_hsa003100.90798886
63African trypanosomiasis_Homo sapiens_hsa051430.90346907
64Histidine metabolism_Homo sapiens_hsa003400.89270340
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.88428957
66Biosynthesis of amino acids_Homo sapiens_hsa012300.88192661
67Measles_Homo sapiens_hsa051620.87765544
68VEGF signaling pathway_Homo sapiens_hsa043700.87274882
69Chemical carcinogenesis_Homo sapiens_hsa052040.84002208
70Chronic myeloid leukemia_Homo sapiens_hsa052200.82926927
71Fat digestion and absorption_Homo sapiens_hsa049750.82567084
72Acute myeloid leukemia_Homo sapiens_hsa052210.82117400
73Butanoate metabolism_Homo sapiens_hsa006500.80964677
74Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80769744
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.79406012
76Folate biosynthesis_Homo sapiens_hsa007900.79398837
77Notch signaling pathway_Homo sapiens_hsa043300.78789251
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.78455849
79Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.78412820
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78077579
81Tuberculosis_Homo sapiens_hsa051520.77312961
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76901171
83Pyruvate metabolism_Homo sapiens_hsa006200.76510142
84RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.76480521
85Neurotrophin signaling pathway_Homo sapiens_hsa047220.76297812
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.75535646
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74937120
88Hematopoietic cell lineage_Homo sapiens_hsa046400.74557516
89Legionellosis_Homo sapiens_hsa051340.74292784
90Platelet activation_Homo sapiens_hsa046110.73799867
91Non-small cell lung cancer_Homo sapiens_hsa052230.73187859
92Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.72121039
93AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.71301562
94Endocytosis_Homo sapiens_hsa041440.70200042
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.69212017
96Renal cell carcinoma_Homo sapiens_hsa052110.68542801
97Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67008889
98Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66933409
99Apoptosis_Homo sapiens_hsa042100.66681644
100Prolactin signaling pathway_Homo sapiens_hsa049170.65337502
101Shigellosis_Homo sapiens_hsa051310.65227479
102Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.65033047
103Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64909117
104Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.64127154
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63924509
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.62465375
107Galactose metabolism_Homo sapiens_hsa000520.61593364
108Influenza A_Homo sapiens_hsa051640.61528016
109Viral myocarditis_Homo sapiens_hsa054160.60808194
110Pancreatic cancer_Homo sapiens_hsa052120.60778091
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.60038073
112Fructose and mannose metabolism_Homo sapiens_hsa000510.59394922
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58898970
114HTLV-I infection_Homo sapiens_hsa051660.58563953
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58222389
116Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.57268372
117Cyanoamino acid metabolism_Homo sapiens_hsa004600.56858563
118Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.56051847
119Small cell lung cancer_Homo sapiens_hsa052220.53984853
120Amoebiasis_Homo sapiens_hsa051460.53753598
121Vibrio cholerae infection_Homo sapiens_hsa051100.53742091
122Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53455417
123Hepatitis B_Homo sapiens_hsa051610.53427391
124Glycerolipid metabolism_Homo sapiens_hsa005610.52526052
125Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52457646
126Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51988565
127Proteoglycans in cancer_Homo sapiens_hsa052050.51350395
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50935193
129TNF signaling pathway_Homo sapiens_hsa046680.50849418
130Phenylalanine metabolism_Homo sapiens_hsa003600.50538001
131GnRH signaling pathway_Homo sapiens_hsa049120.49759954
132HIF-1 signaling pathway_Homo sapiens_hsa040660.49480008
133Sphingolipid metabolism_Homo sapiens_hsa006000.47965421
134Herpes simplex infection_Homo sapiens_hsa051680.47889056
135Epstein-Barr virus infection_Homo sapiens_hsa051690.47845235
136Focal adhesion_Homo sapiens_hsa045100.46883538
137Hepatitis C_Homo sapiens_hsa051600.44635093
138Steroid hormone biosynthesis_Homo sapiens_hsa001400.44469209
139Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43172250
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43141016
141Renin-angiotensin system_Homo sapiens_hsa046140.41293295
142Central carbon metabolism in cancer_Homo sapiens_hsa052300.41102160
143Viral carcinogenesis_Homo sapiens_hsa052030.40295949
144Endometrial cancer_Homo sapiens_hsa052130.36873818
145mTOR signaling pathway_Homo sapiens_hsa041500.35919071
146Insulin signaling pathway_Homo sapiens_hsa049100.32648936
147Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.32635380

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