MGAT2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a Golgi enzyme catalyzing an essential step in the conversion of oligomannose to complex N-glycans. The enzyme has the typical glycosyltransferase domains: a short N-terminal cytoplasmic domain, a hydrophobic non-cleavable signal-anchor domain, and a C-terminal catalytic domain. Mutations in this gene may lead to carbohydrate-deficient glycoprotein syndrome, type II. The coding region of this gene is intronless. Transcript variants with a spliced 5' UTR may exist, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)4.50537562
2COPI coating of Golgi vesicle (GO:0048205)4.50537562
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.46406411
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.46406411
5maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.07730223
6Arp2/3 complex-mediated actin nucleation (GO:0034314)3.86289373
7protein retention in ER lumen (GO:0006621)3.73851229
8protein localization to endosome (GO:0036010)3.65515174
9antigen processing and presentation of endogenous antigen (GO:0019883)3.64855395
10barbed-end actin filament capping (GO:0051016)3.58173010
11response to peptidoglycan (GO:0032494)3.47613883
12pentose-phosphate shunt (GO:0006098)3.46038471
13positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.33674308
14DNA deamination (GO:0045006)3.32436438
15SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.28217807
16cell adhesion mediated by integrin (GO:0033627)3.25341443
17folic acid-containing compound biosynthetic process (GO:0009396)3.21247120
18protein targeting to ER (GO:0045047)3.20658702
19ribosomal small subunit assembly (GO:0000028)3.19979173
20cotranslational protein targeting to membrane (GO:0006613)3.18483198
21signal peptide processing (GO:0006465)3.18390295
22NADPH regeneration (GO:0006740)3.17355658
23NIK/NF-kappaB signaling (GO:0038061)3.14753039
24establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06055472
25protein localization to endoplasmic reticulum (GO:0070972)3.05597163
26folic acid metabolic process (GO:0046655)3.03712838
27regulation of vitamin D biosynthetic process (GO:0060556)3.03658704
28UDP-N-acetylglucosamine metabolic process (GO:0006047)3.02567077
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00998852
30antigen processing and presentation via MHC class Ib (GO:0002475)2.98093536
31COPII vesicle coating (GO:0048208)2.94038117
32negative regulation of phagocytosis (GO:0050765)2.92972134
33hypotonic response (GO:0006971)2.91877179
34lipopolysaccharide-mediated signaling pathway (GO:0031663)2.91686814
35viral transcription (GO:0019083)2.90388512
36positive regulation of nuclease activity (GO:0032075)2.90235386
37translational termination (GO:0006415)2.88796805
38regulation of vitamin metabolic process (GO:0030656)2.87826048
394-hydroxyproline metabolic process (GO:0019471)2.84576964
40activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.84434157
41actin nucleation (GO:0045010)2.82665390
42hyaluronan catabolic process (GO:0030214)2.78807251
43membrane raft organization (GO:0031579)2.77257484
44negative regulation of erythrocyte differentiation (GO:0045647)2.75101064
45regulation of nuclease activity (GO:0032069)2.70074215
46serine family amino acid biosynthetic process (GO:0009070)2.69161506
47valine metabolic process (GO:0006573)2.68276485
48endoplasmic reticulum unfolded protein response (GO:0030968)2.67906011
49cysteine metabolic process (GO:0006534)2.67646181
50regulation of type I interferon-mediated signaling pathway (GO:0060338)2.67396002
51regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.66344649
52negative regulation of interleukin-12 production (GO:0032695)2.64265117
53killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.62885322
54disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.62885322
55translational elongation (GO:0006414)2.60711594
56negative regulation of necroptotic process (GO:0060546)2.59250096
57glycine metabolic process (GO:0006544)2.57526354
58cellular response to unfolded protein (GO:0034620)2.56964970
59cellular response to arsenic-containing substance (GO:0071243)2.55129059
60protein maturation by protein folding (GO:0022417)2.54423779
61embryonic process involved in female pregnancy (GO:0060136)2.53936151
62maternal placenta development (GO:0001893)2.53794820
63sequestering of metal ion (GO:0051238)2.51619990
64formation of translation preinitiation complex (GO:0001731)2.48681212
65pteridine-containing compound biosynthetic process (GO:0042559)2.48257862
66skin morphogenesis (GO:0043589)2.46732102
67ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.46658657
68type I interferon signaling pathway (GO:0060337)2.45909000
69cellular response to type I interferon (GO:0071357)2.45909000
70cellular response to topologically incorrect protein (GO:0035967)2.43966173
71ER-nucleus signaling pathway (GO:0006984)2.43814936
72response to type I interferon (GO:0034340)2.42205337
73DNA strand elongation involved in DNA replication (GO:0006271)2.41028985
74glucose catabolic process (GO:0006007)2.40918660
75positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.40091118
76germinal center formation (GO:0002467)2.39895223
77positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.39650461
78translational initiation (GO:0006413)2.39280871
79lipopolysaccharide biosynthetic process (GO:0009103)2.39155329
80positive regulation of macrophage differentiation (GO:0045651)2.39085631
81response to muramyl dipeptide (GO:0032495)2.38050779
82regulation of T-helper 1 cell differentiation (GO:0045625)2.37455477
83regulation of necroptotic process (GO:0060544)2.37323196
84T cell apoptotic process (GO:0070231)2.36608500
85modulation by symbiont of host cellular process (GO:0044068)2.36468517
86positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.34840421
87glycosphingolipid catabolic process (GO:0046479)2.34202675
88low-density lipoprotein particle clearance (GO:0034383)2.32162852
89* protein N-linked glycosylation via asparagine (GO:0018279)2.31945126
90response to laminar fluid shear stress (GO:0034616)2.31224353
91folic acid-containing compound metabolic process (GO:0006760)2.30653429
92positive regulation of B cell differentiation (GO:0045579)2.30179633
93DNA unwinding involved in DNA replication (GO:0006268)2.29692322
94* peptidyl-asparagine modification (GO:0018196)2.28642430
95nucleotide-sugar biosynthetic process (GO:0009226)2.28359530
96stress fiber assembly (GO:0043149)2.28310237
97serine family amino acid metabolic process (GO:0009069)2.27398370
98viral life cycle (GO:0019058)2.26578509
99negative regulation of nitric oxide biosynthetic process (GO:0045019)2.26455338
100myeloid dendritic cell differentiation (GO:0043011)2.26443643
101nucleoside salvage (GO:0043174)2.26371481
102DNA strand elongation (GO:0022616)2.26229073
103regulation of necrotic cell death (GO:0010939)2.25827192
104tetrahydrofolate metabolic process (GO:0046653)2.25744347
105membrane protein ectodomain proteolysis (GO:0006509)2.25346704
106folic acid transport (GO:0015884)2.24145566
107nucleobase biosynthetic process (GO:0046112)2.24013758
108telomere maintenance via semi-conservative replication (GO:0032201)2.23998080
109mature B cell differentiation involved in immune response (GO:0002313)2.22795820
110positive regulation of natural killer cell differentiation (GO:0032825)2.22690203
111sulfur amino acid catabolic process (GO:0000098)2.21650300
1123-UTR-mediated mRNA stabilization (GO:0070935)2.21533845
113L-serine metabolic process (GO:0006563)2.21034198
114peptidyl-proline hydroxylation (GO:0019511)2.20855079
115nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.20077004
116protein targeting to membrane (GO:0006612)2.19331351
117apoptotic cell clearance (GO:0043277)2.19055978
118lipopolysaccharide metabolic process (GO:0008653)2.18832716
119ribosome assembly (GO:0042255)2.18523801
120regulation of leukocyte degranulation (GO:0043300)2.18074795
121urate metabolic process (GO:0046415)2.17131778
122mitotic chromosome condensation (GO:0007076)2.16625514
123myeloid dendritic cell activation (GO:0001773)2.16154928
124nucleobase-containing small molecule interconversion (GO:0015949)2.16099862
125response to interferon-alpha (GO:0035455)2.15554655
126ribosomal small subunit biogenesis (GO:0042274)2.15391135
127natural killer cell mediated immunity (GO:0002228)2.15118640
128natural killer cell mediated cytotoxicity (GO:0042267)2.15118640
129* protein N-linked glycosylation (GO:0006487)2.15067708
130T cell migration (GO:0072678)2.14922526
131regulation of protein heterodimerization activity (GO:0043497)2.14574536
132maturation of SSU-rRNA (GO:0030490)2.14177382
133positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.13858312
134purine nucleobase biosynthetic process (GO:0009113)2.13782441
135pinocytosis (GO:0006907)2.13750786
136regulation of podosome assembly (GO:0071801)2.13573297
137response to endoplasmic reticulum stress (GO:0034976)2.13346666
138one-carbon metabolic process (GO:0006730)2.13296776
139regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.12744136
140pteridine-containing compound metabolic process (GO:0042558)2.12452554
141DNA replication initiation (GO:0006270)2.12292405
142positive regulation of gamma-delta T cell activation (GO:0046645)2.11795643
143glycolipid catabolic process (GO:0019377)2.10987494
144positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.10751401
145lymphocyte apoptotic process (GO:0070227)2.10716585
146response to fungus (GO:0009620)2.10679316
147peptidyl-glutamic acid carboxylation (GO:0017187)2.09979939
148protein carboxylation (GO:0018214)2.09979939
149cortical actin cytoskeleton organization (GO:0030866)2.09950673
150positive regulation of chemokine biosynthetic process (GO:0045080)2.09541893
151detection of molecule of bacterial origin (GO:0032490)2.09260473
152IMP metabolic process (GO:0046040)2.08860210
153regulation of integrin activation (GO:0033623)2.08856182
154regulation of mast cell degranulation (GO:0043304)2.08747032
155regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.08109280
156NADP metabolic process (GO:0006739)2.07506140
157definitive hemopoiesis (GO:0060216)2.07460184
158wound healing, spreading of epidermal cells (GO:0035313)2.07321729
159regulation of glucose import in response to insulin stimulus (GO:2001273)2.06073686
160regulation of response to interferon-gamma (GO:0060330)2.05943107
161negative regulation of cell killing (GO:0031342)2.05927681
162negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.05927681
163regulation of cytokine secretion involved in immune response (GO:0002739)2.05401197
164regulation of interferon-beta biosynthetic process (GO:0045357)2.05230448
165immunoglobulin mediated immune response (GO:0016064)2.04094445
166cellular protein complex disassembly (GO:0043624)2.03766650
167defense response to fungus (GO:0050832)2.03608161
168positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.03456995
169necroptotic process (GO:0070266)2.02724681
170lysine metabolic process (GO:0006553)2.02276377
171lysine catabolic process (GO:0006554)2.02276377
172peptide catabolic process (GO:0043171)2.02195855
173regulation of tight junction assembly (GO:2000810)2.02100294
174neutrophil mediated immunity (GO:0002446)2.01853010
175respiratory burst (GO:0045730)2.01728309
176positive regulation of tumor necrosis factor production (GO:0032760)1.99999717
177regulation of interferon-alpha production (GO:0032647)1.99395989
178positive regulation of endothelial cell apoptotic process (GO:2000353)1.99382371
179negative regulation of anoikis (GO:2000811)1.99183298
180spliceosomal tri-snRNP complex assembly (GO:0000244)1.98694046
181oligosaccharide catabolic process (GO:0009313)1.98438407
182dendritic cell differentiation (GO:0097028)1.97652806
183chronic inflammatory response (GO:0002544)1.97545925
184negative regulation of protein localization to plasma membrane (GO:1903077)1.96923609

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.65980695
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29335713
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.22898481
4MYC_18555785_ChIP-Seq_MESCs_Mouse2.76841562
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.74611774
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.52717502
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.43286521
8MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.34908444
9MYB_21317192_ChIP-Seq_ERMYB_Mouse2.34732670
10* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.18070900
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11040228
12MYC_22102868_ChIP-Seq_BL_Human2.10156323
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.01843212
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.99525154
15ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96985295
16GABP_17652178_ChIP-ChIP_JURKAT_Human1.94100239
17* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.93253659
18ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.91447188
19ZNF263_19887448_ChIP-Seq_K562_Human1.86881901
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.86537337
21VDR_21846776_ChIP-Seq_THP-1_Human1.84705661
22* RXR_22158963_ChIP-Seq_LIVER_Mouse1.84463046
23PPARA_22158963_ChIP-Seq_LIVER_Mouse1.83057833
24FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.80769706
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80478264
26PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77557466
27IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.77389558
28* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.75459184
29IRF8_21731497_ChIP-ChIP_J774_Mouse1.71552827
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69734762
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69031366
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.66969316
33* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.66876488
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65365581
35MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64947931
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.64412321
37* SPI1_23547873_ChIP-Seq_NB4_Human1.63875663
38GATA1_22025678_ChIP-Seq_K562_Human1.63699483
39CREB1_15753290_ChIP-ChIP_HEK293T_Human1.62776457
40KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62174773
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.62055050
42NELFA_20434984_ChIP-Seq_ESCs_Mouse1.61794922
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.61552327
44AR_21909140_ChIP-Seq_LNCAP_Human1.60851810
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.60379027
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.58994781
47ETS1_20019798_ChIP-Seq_JURKAT_Human1.57930546
48* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.57526859
49MYC_19079543_ChIP-ChIP_MESCs_Mouse1.57361360
50* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.56599050
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.55743209
52* VDR_23849224_ChIP-Seq_CD4+_Human1.51473382
53CLOCK_20551151_ChIP-Seq_293T_Human1.49124601
54EST1_17652178_ChIP-ChIP_JURKAT_Human1.48760953
55TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48358158
56XRN2_22483619_ChIP-Seq_HELA_Human1.48153290
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47001190
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.46196656
59SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.45481084
60* DCP1A_22483619_ChIP-Seq_HELA_Human1.44944848
61* FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43117331
62SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.42545236
63MYB_26560356_Chip-Seq_TH2_Human1.42061590
64TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40460587
65E2F1_18555785_ChIP-Seq_MESCs_Mouse1.38822062
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37379078
67VDR_24763502_ChIP-Seq_THP-1_Human1.37374985
68TFEB_21752829_ChIP-Seq_HELA_Human1.36335665
69* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.35946485
70Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.34482011
71IRF8_27001747_Chip-Seq_BMDM_Mouse1.34449521
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.34255933
73HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.33909765
74MAF_26560356_Chip-Seq_TH1_Human1.33048179
75* MYB_26560356_Chip-Seq_TH1_Human1.32772608
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31813301
77GABP_19822575_ChIP-Seq_HepG2_Human1.31779130
78E2F1_21310950_ChIP-Seq_MCF-7_Human1.30591458
79SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30031528
80ELK1_19687146_ChIP-ChIP_HELA_Human1.29878064
81LXR_22292898_ChIP-Seq_THP-1_Human1.29659476
82STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.29593899
83KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.28230070
84EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27730475
85CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.27422934
86SCL_19346495_ChIP-Seq_HPC-7_Human1.26087869
87STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25521361
88SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.24677353
89SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.24677353
90FOXP3_21729870_ChIP-Seq_TREG_Human1.24509441
91MAF_26560356_Chip-Seq_TH2_Human1.23866945
92GATA1_22383799_ChIP-Seq_G1ME_Mouse1.23860146
93GATA2_21666600_ChIP-Seq_HMVEC_Human1.23708133
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.23076872
95* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.22736257
96UTX_26944678_Chip-Seq_JUKART_Human1.21287983
97* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21133738
98TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21106078
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.19709533
100SMAD_19615063_ChIP-ChIP_OVARY_Human1.19540699
101KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19523153
102NOTCH1_21737748_ChIP-Seq_TLL_Human1.19148318
103HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.18943780
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17200287
105NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16158106
106PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15889848
107LXR_22158963_ChIP-Seq_LIVER_Mouse1.15888824
108* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.15518064
109* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.15367556
110TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.15361855
111* UBF1/2_26484160_Chip-Seq_HMECs_Human1.12363790
112RACK7_27058665_Chip-Seq_MCF-7_Human1.11955910
113STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.10674499
114CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09695742
115KDM5A_27292631_Chip-Seq_BREAST_Human1.09487006
116MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09127460
117TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07454029
118* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07262735
119KLF4_18555785_ChIP-Seq_MESCs_Mouse1.07224944
120STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.06610988
121E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.05955933
122RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.05344756
123KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04040018
124HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03778692
125KDM2B_26808549_Chip-Seq_DND41_Human1.03139158
126RARG_19884340_ChIP-ChIP_MEFs_Mouse1.01643451
127IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.01444071
128NCOR1_26117541_ChIP-Seq_K562_Human1.01419533
129KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.01378859
130TCF7_22412390_ChIP-Seq_EML_Mouse1.01366248
131SPI1_23127762_ChIP-Seq_K562_Human1.01209689
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01066202
133CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01034789
134STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.99650513
135TP63_17297297_ChIP-ChIP_HaCaT_Human0.96735347
136DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.95612899
137ATF3_27146783_Chip-Seq_COLON_Human0.95092346

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition2.56036078
2MP0006054_spinal_hemorrhage2.50669125
3MP0005360_urolithiasis2.37200832
4MP0008438_abnormal_cutaneous_collagen2.37107534
5MP0002139_abnormal_hepatobiliary_system2.31739336
6MP0003300_gastrointestinal_ulcer2.27743225
7MP0003705_abnormal_hypodermis_morpholog2.25573265
8MP0002396_abnormal_hematopoietic_system2.18350071
9MP0003436_decreased_susceptibility_to2.13931268
10MP0005058_abnormal_lysosome_morphology1.99948579
11MP0001835_abnormal_antigen_presentation1.94497945
12MP0003693_abnormal_embryo_hatching1.90466855
13MP0010352_gastrointestinal_tract_polyps1.90455129
14MP0003303_peritoneal_inflammation1.89178721
15MP0005365_abnormal_bile_salt1.87683961
16MP0009840_abnormal_foam_cell1.86585085
17MP0002166_altered_tumor_susceptibility1.84420979
18MP0005623_abnormal_meninges_morphology1.77308172
19MP0003091_abnormal_cell_migration1.69325951
20MP0005220_abnormal_exocrine_pancreas1.68102327
21MP0008004_abnormal_stomach_pH1.67185932
22MP0009333_abnormal_splenocyte_physiolog1.65887693
23MP0003191_abnormal_cellular_cholesterol1.61627592
24MP0003724_increased_susceptibility_to1.61474009
25MP0000490_abnormal_crypts_of1.61098493
26MP0000685_abnormal_immune_system1.60603335
27MP0005464_abnormal_platelet_physiology1.60415347
28MP0003806_abnormal_nucleotide_metabolis1.58299628
29MP0001666_abnormal_nutrient_absorption1.57606930
30MP0004272_abnormal_basement_membrane1.50508951
31MP0000343_altered_response_to1.50457807
32MP0004957_abnormal_blastocyst_morpholog1.47133458
33MP0009785_altered_susceptibility_to1.45475138
34MP0002419_abnormal_innate_immunity1.44808274
35MP0004808_abnormal_hematopoietic_stem1.42851951
36MP0005085_abnormal_gallbladder_physiolo1.41285718
37MP0003828_pulmonary_edema1.40404501
38MP0003453_abnormal_keratinocyte_physiol1.40270371
39MP0005000_abnormal_immune_tolerance1.38866649
40MP0005025_abnormal_response_to1.37966731
41MP0010368_abnormal_lymphatic_system1.37722189
42MP0002877_abnormal_melanocyte_morpholog1.36647797
43MP0001533_abnormal_skeleton_physiology1.36179231
44MP0005083_abnormal_biliary_tract1.34578689
45MP0001873_stomach_inflammation1.33356233
46MP0002452_abnormal_antigen_presenting1.32047609
47MP0002998_abnormal_bone_remodeling1.29726835
48MP0003566_abnormal_cell_adhesion1.29407212
49MP0002006_tumorigenesis1.28799023
50MP0001800_abnormal_humoral_immune1.28130981
51MP0005397_hematopoietic_system_phenotyp1.27665526
52MP0001545_abnormal_hematopoietic_system1.27665526
53* MP0001845_abnormal_inflammatory_respons1.26997923
54MP0010307_abnormal_tumor_latency1.25867802
55MP0003186_abnormal_redox_activity1.24223640
56MP0002420_abnormal_adaptive_immunity1.23763701
57MP0002723_abnormal_immune_serum1.23630365
58MP0010155_abnormal_intestine_physiology1.23076421
59MP0010234_abnormal_vibrissa_follicle1.22729627
60MP0003075_altered_response_to1.22589112
61MP0000858_altered_metastatic_potential1.21845931
62MP0001819_abnormal_immune_cell1.21804993
63MP0003252_abnormal_bile_duct1.21753267
64* MP0002398_abnormal_bone_marrow1.20993156
65MP0003763_abnormal_thymus_physiology1.19368592
66* MP0000689_abnormal_spleen_morphology1.18431115
67MP0004947_skin_inflammation1.17311177
68MP0005671_abnormal_response_to1.17069305
69* MP0008469_abnormal_protein_level1.16518774
70MP0005023_abnormal_wound_healing1.16518617
71* MP0009643_abnormal_urine_homeostasis1.16226285
72MP0000609_abnormal_liver_physiology1.14995297
73MP0002405_respiratory_system_inflammati1.13445855
74* MP0002722_abnormal_immune_system1.13196247
75MP0002138_abnormal_hepatobiliary_system1.12927626
76MP0001790_abnormal_immune_system1.11834594
77MP0005387_immune_system_phenotype1.11834594
78MP0003950_abnormal_plasma_membrane1.11126110
79MP0004233_abnormal_muscle_weight1.10167532
80* MP0000716_abnormal_immune_system1.09280198
81MP0005257_abnormal_intraocular_pressure1.09137051
82MP0008875_abnormal_xenobiotic_pharmacok1.07652722
83MP0004510_myositis1.07650528
84* MP0002429_abnormal_blood_cell1.06524428
85MP0005319_abnormal_enzyme/_coenzyme1.05084646
86MP0000598_abnormal_liver_morphology1.04591181
87MP0009384_cardiac_valve_regurgitation1.04163451
88MP0005164_abnormal_response_to1.03723911
89MP0003279_aneurysm1.02936402
90MP0005332_abnormal_amino_acid1.01905306
91MP0001542_abnormal_bone_strength1.01749086
92MP0001849_ear_inflammation1.01390105
93MP0008007_abnormal_cellular_replicative1.01200659
94MP0005275_abnormal_skin_tensile1.01191167
95MP0001958_emphysema1.01016681
96MP0002148_abnormal_hypersensitivity_rea1.00995549
97MP0002933_joint_inflammation1.00972997
98MP0005166_decreased_susceptibility_to1.00733488
99MP0003172_abnormal_lysosome_physiology0.99938575
100MP0008260_abnormal_autophagy0.99247115
101MP0003656_abnormal_erythrocyte_physiolo0.98952920
102MP0006082_CNS_inflammation0.98250415
103MP0000767_abnormal_smooth_muscle0.95924640
104MP0005165_increased_susceptibility_to0.95477267
105MP0002019_abnormal_tumor_incidence0.94887188
106MP0003868_abnormal_feces_composition0.94068542
107MP0010329_abnormal_lipoprotein_level0.93141267
108MP0009697_abnormal_copulation0.91838618
109MP0003077_abnormal_cell_cycle0.90980882
110MP0005076_abnormal_cell_differentiation0.90315421
111MP0004185_abnormal_adipocyte_glucose0.90309583
112MP0009764_decreased_sensitivity_to0.89213803
113MP0001853_heart_inflammation0.88522667
114MP0010094_abnormal_chromosome_stability0.87246247
115MP0003195_calcinosis0.87100294
116MP0001661_extended_life_span0.86888793
117MP0002060_abnormal_skin_morphology0.86340527
118MP0000604_amyloidosis0.84980119
119MP0005621_abnormal_cell_physiology0.84268406
120MP0003448_altered_tumor_morphology0.83870653
121* MP0003795_abnormal_bone_structure0.83295201
122MP0003183_abnormal_peptide_metabolism0.83013852
123* MP0000465_gastrointestinal_hemorrhage0.82279631
124MP0009278_abnormal_bone_marrow0.81031268
125MP0001243_abnormal_dermal_layer0.80984416
126MP0009763_increased_sensitivity_to0.80638391
127MP0000358_abnormal_cell_content/0.80003167
128MP0003221_abnormal_cardiomyocyte_apopto0.79992252
129MP0002332_abnormal_exercise_endurance0.79224676
130MP0005408_hypopigmentation0.77968072
131MP0003111_abnormal_nucleus_morphology0.77937071
132MP0001915_intracranial_hemorrhage0.77919343

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)3.71953523
2Vacuolated lymphocytes (HP:0001922)3.35174744
3Protrusio acetabuli (HP:0003179)3.16680130
4Abnormality of glycolipid metabolism (HP:0010969)3.02414928
5Abnormality of liposaccharide metabolism (HP:0010968)3.02414928
6Abnormality of glycosphingolipid metabolism (HP:0004343)3.02414928
7Dysostosis multiplex (HP:0000943)2.96318939
8Spinal cord lesions (HP:0100561)2.95236560
9Syringomyelia (HP:0003396)2.95236560
10Cervical subluxation (HP:0003308)2.79353381
11Mucopolysacchariduria (HP:0008155)2.72996536
12Urinary glycosaminoglycan excretion (HP:0003541)2.72996536
13IgM deficiency (HP:0002850)2.72879438
14Premature rupture of membranes (HP:0001788)2.68837670
15Abnormality of the common coagulation pathway (HP:0010990)2.64727451
16Beaking of vertebral bodies (HP:0004568)2.63217995
17Abnormality of cells of the erythroid lineage (HP:0012130)2.56448907
18Elevated erythrocyte sedimentation rate (HP:0003565)2.53930333
19Impaired platelet aggregation (HP:0003540)2.53545950
20Abnormal platelet function (HP:0011869)2.53545950
21Abnormality of aromatic amino acid family metabolism (HP:0004338)2.51663677
22Eczematoid dermatitis (HP:0000976)2.49796111
23Abnormality of the distal phalanges of the toes (HP:0010182)2.48827041
24Chronic otitis media (HP:0000389)2.48630845
25Abnormal number of erythroid precursors (HP:0012131)2.47261599
26Recurrent abscess formation (HP:0002722)2.45918809
27Peritonitis (HP:0002586)2.40779756
28Recurrent bacterial skin infections (HP:0005406)2.38737805
29Hypoglycemic coma (HP:0001325)2.35380763
30Petechiae (HP:0000967)2.35075342
31Xanthomatosis (HP:0000991)2.34164605
32Abnormality of mucopolysaccharide metabolism (HP:0011020)2.33092054
33Abnormality of polysaccharide metabolism (HP:0011012)2.33092054
34Abnormality of glycosaminoglycan metabolism (HP:0004371)2.33092054
35Osteolytic defects of the phalanges of the hand (HP:0009771)2.32687005
36Osteolytic defects of the hand bones (HP:0009699)2.32687005
37Nonimmune hydrops fetalis (HP:0001790)2.31321935
38Colitis (HP:0002583)2.29080209
39Joint stiffness (HP:0001387)2.28802457
40Short nail (HP:0001799)2.28443041
41Mediastinal lymphadenopathy (HP:0100721)2.27477633
42Atrophic scars (HP:0001075)2.23823848
43Myositis (HP:0100614)2.20643851
44Abnormality of monocarboxylic acid metabolism (HP:0010996)2.18664662
45Abnormality of T cell physiology (HP:0011840)2.18459543
46Recurrent gram-negative bacterial infections (HP:0005420)2.18346408
47Myocardial infarction (HP:0001658)2.15697848
48Ankle contracture (HP:0006466)2.14982268
49Vertebral compression fractures (HP:0002953)2.14972546
50Spinal rigidity (HP:0003306)2.14375310
51Interstitial pulmonary disease (HP:0006530)2.14095741
52Entropion (HP:0000621)2.13079440
53Achilles tendon contracture (HP:0001771)2.12811449
54Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.11763324
55Aortic aneurysm (HP:0004942)2.10983281
56Deep venous thrombosis (HP:0002625)2.10585001
57Hematochezia (HP:0002573)2.09886645
58Epistaxis (HP:0000421)2.09572589
59Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.08429414
60Wormian bones (HP:0002645)2.07890889
61Elbow flexion contracture (HP:0002987)2.07700965
62Multiple enchondromatosis (HP:0005701)2.05572304
63Spastic diplegia (HP:0001264)2.04695043
64* Abnormality of the intrinsic pathway (HP:0010989)2.03938949
65Pustule (HP:0200039)2.03074156
66Gastrointestinal inflammation (HP:0004386)2.02151348
67Blue sclerae (HP:0000592)2.02104904
68Spontaneous hematomas (HP:0007420)2.01325972
69Aplastic anemia (HP:0001915)1.99950355
70Loss of speech (HP:0002371)1.99676704
71Cerebral aneurysm (HP:0004944)1.99417120
72Inflammation of the large intestine (HP:0002037)1.98983851
73Abnormal foot bone ossification (HP:0010675)1.98555360
74Severe short stature (HP:0003510)1.98076461
75Orchitis (HP:0100796)1.97779510
76Abnormality of transition element cation homeostasis (HP:0011030)1.96315395
77Flat acetabular roof (HP:0003180)1.94225860
78Increased serum ferritin (HP:0003281)1.93730238
79Abnormality of the Achilles tendon (HP:0005109)1.92954414
80Abnormal platelet volume (HP:0011876)1.92911083
81Abnormal cartilage morphology (HP:0002763)1.92834180
82Recurrent viral infections (HP:0004429)1.92480275
83Nasal polyposis (HP:0100582)1.92465278
84Hypertensive crisis (HP:0100735)1.92098252
85Reticulocytopenia (HP:0001896)1.91287520
86Cellulitis (HP:0100658)1.90115547
87Abnormality of the nasal mucosa (HP:0000433)1.89942045
88Abnormality of carpal bone ossification (HP:0006257)1.89710174
89Mitral stenosis (HP:0001718)1.89135274
90Multiple lipomas (HP:0001012)1.88851143
91Aortic dissection (HP:0002647)1.88781752
92Gout (HP:0001997)1.88109293
93Abnormality of iron homeostasis (HP:0011031)1.87989648
94Microretrognathia (HP:0000308)1.87947491
95Fatigue (HP:0012378)1.87451140
96Upper motor neuron abnormality (HP:0002127)1.87252926
97Gastrointestinal infarctions (HP:0005244)1.86785548
98Abnormality of the vasculature of the conjunctiva (HP:0008054)1.86080402
99Bone pain (HP:0002653)1.85929473
100Hepatosplenomegaly (HP:0001433)1.84943931
101Abnormality of macrophages (HP:0004311)1.84612562
102Thrombophlebitis (HP:0004418)1.84316134
103Menorrhagia (HP:0000132)1.83919451
104Vascular tortuosity (HP:0004948)1.83896259
105IgA deficiency (HP:0002720)1.83376249
106Poor head control (HP:0002421)1.81511925
107Abnormality of the peritoneum (HP:0002585)1.80832772
108Abnormality of purine metabolism (HP:0004352)1.80497118
109Genu recurvatum (HP:0002816)1.79555956
110Reduced subcutaneous adipose tissue (HP:0003758)1.78806504
111Increased mean platelet volume (HP:0011877)1.77808508
112Fragile skin (HP:0001030)1.77448880
113Thin bony cortex (HP:0002753)1.77288986
114Generalized aminoaciduria (HP:0002909)1.77255624
115Abnormality of subcutaneous fat tissue (HP:0001001)1.76074481
116Intrahepatic cholestasis (HP:0001406)1.75780175
117Arterial tortuosity (HP:0005116)1.75429910
118Arterial thrombosis (HP:0004420)1.75327936
119Abnormal ossification of hand bones (HP:0005921)1.75043868
120Centrally nucleated skeletal muscle fibers (HP:0003687)1.74742707
121Biconcave vertebral bodies (HP:0004586)1.74573209
122Polycythemia (HP:0001901)1.74284258
123Hypobetalipoproteinemia (HP:0003563)1.73844141
124Purpura (HP:0000979)1.73562925
125Abnormality of complement system (HP:0005339)1.73317660
126Gingival bleeding (HP:0000225)1.71460677
127Vasculitis (HP:0002633)1.70835199
128Increased density of long bones (HP:0006392)1.70003610
129Abnormality of T cells (HP:0002843)1.69794366
130Spondylolisthesis (HP:0003302)1.68905780
131Short clavicles (HP:0000894)1.68902782
132Increased cerebral lipofuscin (HP:0011813)1.67762793
133Abnormality of glutamine family amino acid metabolism (HP:0010902)1.67729289
134Abnormality of nucleobase metabolism (HP:0010932)1.67727215
135Abnormality of the umbilical cord (HP:0010881)1.66844136
136Fat malabsorption (HP:0002630)1.66798149
137Abnormal tarsal ossification (HP:0008369)1.66622190
138Recurrent bronchitis (HP:0002837)1.66244268
139Abnormality of the acetabulum (HP:0003170)1.66076193
140Radial bowing (HP:0002986)1.65721251
141Tetraparesis (HP:0002273)1.65418562
142Rough bone trabeculation (HP:0100670)1.65025412
143Dilatation of the ascending aorta (HP:0005111)1.64678716
144Amyloidosis (HP:0011034)1.64420259
145Chronic obstructive pulmonary disease (HP:0006510)1.64062365
146Obstructive lung disease (HP:0006536)1.64062365
147Generalized amyotrophy (HP:0003700)1.64003561
148Elevated alkaline phosphatase (HP:0003155)1.63567150
149Abnormality of sulfur amino acid metabolism (HP:0004339)1.62276574
150Systemic lupus erythematosus (HP:0002725)1.61450790
151Macrocytic anemia (HP:0001972)1.61418311
152Polygenic inheritance (HP:0010982)1.60887633
153Gastrointestinal stroma tumor (HP:0100723)1.60829370
154Conjunctival telangiectasia (HP:0000524)1.60314301
155Recurrent skin infections (HP:0001581)1.60226398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.48648393
2PRPF4B3.47895278
3NME23.25274449
4SCYL22.97757696
5EIF2AK32.82061175
6PKN22.80832214
7TRIB32.52868037
8FLT32.31671458
9TAOK22.18111033
10EEF2K2.14673146
11BCKDK2.14301833
12MAP4K12.05822258
13SMG11.93234708
14PIM21.85772294
15LATS11.81951173
16WEE11.78277951
17ZAP701.73722739
18JAK31.69910175
19ACVR1B1.65989647
20TAOK31.63695350
21LRRK21.62259903
22KDR1.60741306
23EIF2AK11.60186596
24ARAF1.59467299
25MAP2K31.58221244
26MOS1.56061512
27KIT1.55765223
28STK101.52578704
29TBK11.52280648
30TYK21.48773891
31TEC1.45074414
32BTK1.43758514
33RPS6KA41.43375535
34MAP3K31.43127827
35MAP3K101.43109143
36TESK21.42063120
37BLK1.40552853
38BUB11.36883579
39MAP3K131.30145093
40BRSK21.30100607
41TGFBR21.24682448
42NEK91.21139582
43NEK21.21052475
44PASK1.19001839
45DDR21.18322731
46PAK41.17651071
47CDK121.13004484
48CSF1R1.12299156
49PIK3CG1.11336681
50FRK1.10095744
51MAP3K81.05845926
52DYRK31.05756577
53RPS6KB21.02590874
54ICK1.01960052
55TESK11.01271122
56FGFR41.00783494
57PTK61.00540014
58MYLK0.99411318
59PIM10.98163906
60IRAK40.97711169
61TGFBR10.96762000
62CDK40.95161925
63CDC70.95023040
64MAP3K10.94476254
65MAPKAPK30.91026388
66IRAK30.87696438
67TTN0.87455249
68PAK20.87060396
69DAPK30.86722918
70ITK0.85899578
71CLK10.84893201
72LATS20.82798329
73MAP3K110.82469934
74STK30.81946431
75GRK70.81706179
76BMPR20.80765349
77MST1R0.80579634
78ABL20.77016627
79PBK0.75711192
80GRK60.73377689
81NLK0.72180589
82MATK0.70961896
83MAP3K60.70402033
84MELK0.69976284
85ERBB40.69520206
86CSK0.69506820
87CDK60.67980848
88JAK20.67928963
89SYK0.66448479
90STK160.65691035
91CDC42BPA0.63901290
92SIK10.63733735
93LCK0.63148208
94LYN0.63052625
95CAMKK20.62412207
96IRAK20.61584425
97BRAF0.60089002
98AURKB0.59618853
99JAK10.59511375
100RPS6KL10.59276278
101RPS6KC10.59276278
102MAP2K20.59150873
103IKBKE0.58766644
104CCNB10.58054925
105RPS6KA50.58000339
106TAOK10.57594321
107IKBKB0.56557971
108MAPK110.55359933
109CDK70.55168998
110PDGFRA0.55043574
111FGR0.53094119
112TIE10.52981371
113RIPK10.51878263
114MET0.50836784
115EPHA20.49941098
116LIMK10.49599353
117FES0.49426312
118HCK0.49245744
119MAP3K140.48511777
120TAF10.47561393
121RPS6KA20.47379737
122EPHB10.47263581
123CDK90.46957615
124DAPK10.46392743
125PTK20.45854782
126RAF10.45148305
127CDK80.45080837
128MAP3K50.41423039
129MARK30.41133578
130STK40.39458494
131MAP3K20.38074618
132VRK10.37841364
133DYRK1B0.35352278
134PRKG20.35174898
135ILK0.34883316
136TRPM70.33961957
137TXK0.32838769
138ABL10.32823412
139ATR0.31036317

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.74560199
2DNA replication_Homo sapiens_hsa030302.46320832
3Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.25623803
4Folate biosynthesis_Homo sapiens_hsa007902.17061488
5Selenocompound metabolism_Homo sapiens_hsa004502.01166309
6Ribosome_Homo sapiens_hsa030101.97876543
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92346289
8Other glycan degradation_Homo sapiens_hsa005111.83195413
9Pentose and glucuronate interconversions_Homo sapiens_hsa000401.71476889
10One carbon pool by folate_Homo sapiens_hsa006701.68495886
11TNF signaling pathway_Homo sapiens_hsa046681.63881033
12Glycosaminoglycan degradation_Homo sapiens_hsa005311.61569941
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.56998163
14Antigen processing and presentation_Homo sapiens_hsa046121.56268904
15Sulfur relay system_Homo sapiens_hsa041221.56227092
16Pentose phosphate pathway_Homo sapiens_hsa000301.56176359
17* N-Glycan biosynthesis_Homo sapiens_hsa005101.54821248
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.46817965
19Allograft rejection_Homo sapiens_hsa053301.46127622
20Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.43565035
21Viral myocarditis_Homo sapiens_hsa054161.40042781
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.39215238
23Renin-angiotensin system_Homo sapiens_hsa046141.36159151
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.30845029
25Legionellosis_Homo sapiens_hsa051341.27956418
26Salmonella infection_Homo sapiens_hsa051321.27940171
27Graft-versus-host disease_Homo sapiens_hsa053321.27303783
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.25504268
29Lysosome_Homo sapiens_hsa041421.24140999
30Proteasome_Homo sapiens_hsa030501.21491157
31Pyrimidine metabolism_Homo sapiens_hsa002401.20787941
32Mismatch repair_Homo sapiens_hsa034301.20153277
33Staphylococcus aureus infection_Homo sapiens_hsa051501.17950739
34Caffeine metabolism_Homo sapiens_hsa002321.17397993
35Leishmaniasis_Homo sapiens_hsa051401.17144912
36Complement and coagulation cascades_Homo sapiens_hsa046101.16653611
37Autoimmune thyroid disease_Homo sapiens_hsa053201.14417922
38p53 signaling pathway_Homo sapiens_hsa041151.11735321
39Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.11418432
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11011853
41Hepatitis C_Homo sapiens_hsa051601.10858490
42Base excision repair_Homo sapiens_hsa034101.09358447
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09006134
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.07324487
45NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06054777
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04047915
47Sulfur metabolism_Homo sapiens_hsa009201.03539837
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.02680879
49Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.01932481
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99737791
51Rheumatoid arthritis_Homo sapiens_hsa053230.99587844
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97667470
53Biosynthesis of amino acids_Homo sapiens_hsa012300.96621621
54Cysteine and methionine metabolism_Homo sapiens_hsa002700.95190519
55Starch and sucrose metabolism_Homo sapiens_hsa005000.94877514
56Prion diseases_Homo sapiens_hsa050200.93053051
57Cell cycle_Homo sapiens_hsa041100.91984037
58HTLV-I infection_Homo sapiens_hsa051660.90915197
59Non-small cell lung cancer_Homo sapiens_hsa052230.90511566
60Vitamin digestion and absorption_Homo sapiens_hsa049770.90452668
61Apoptosis_Homo sapiens_hsa042100.89637453
62Nucleotide excision repair_Homo sapiens_hsa034200.89062154
63Asthma_Homo sapiens_hsa053100.89054533
64RNA transport_Homo sapiens_hsa030130.88617024
65Shigellosis_Homo sapiens_hsa051310.87794141
66Tryptophan metabolism_Homo sapiens_hsa003800.86772709
67Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86010241
68Amoebiasis_Homo sapiens_hsa051460.85336065
69Glutathione metabolism_Homo sapiens_hsa004800.85285359
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85095864
71Central carbon metabolism in cancer_Homo sapiens_hsa052300.84853870
72Galactose metabolism_Homo sapiens_hsa000520.83989406
73Fat digestion and absorption_Homo sapiens_hsa049750.83930835
74Fatty acid degradation_Homo sapiens_hsa000710.83079386
75Focal adhesion_Homo sapiens_hsa045100.83033405
76Measles_Homo sapiens_hsa051620.80094220
77Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.80054685
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.79639923
79Small cell lung cancer_Homo sapiens_hsa052220.79351336
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77694956
81Malaria_Homo sapiens_hsa051440.77360476
82RNA polymerase_Homo sapiens_hsa030200.76143445
83T cell receptor signaling pathway_Homo sapiens_hsa046600.75733588
84Carbon metabolism_Homo sapiens_hsa012000.74568346
85Homologous recombination_Homo sapiens_hsa034400.73956122
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.73821655
87Proteoglycans in cancer_Homo sapiens_hsa052050.72716519
88Systemic lupus erythematosus_Homo sapiens_hsa053220.72279910
89Osteoclast differentiation_Homo sapiens_hsa043800.71950619
90Herpes simplex infection_Homo sapiens_hsa051680.71702330
91Spliceosome_Homo sapiens_hsa030400.71568585
92Peroxisome_Homo sapiens_hsa041460.70580845
93Pertussis_Homo sapiens_hsa051330.70540626
94Protein digestion and absorption_Homo sapiens_hsa049740.70438020
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.70355077
96Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.69052778
97B cell receptor signaling pathway_Homo sapiens_hsa046620.68733101
98Primary immunodeficiency_Homo sapiens_hsa053400.68533768
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67723791
100Hepatitis B_Homo sapiens_hsa051610.67564714
101Prostate cancer_Homo sapiens_hsa052150.66845260
102Adipocytokine signaling pathway_Homo sapiens_hsa049200.65419307
103African trypanosomiasis_Homo sapiens_hsa051430.64898090
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64766000
105Chronic myeloid leukemia_Homo sapiens_hsa052200.63806941
106Toxoplasmosis_Homo sapiens_hsa051450.63769264
107Type I diabetes mellitus_Homo sapiens_hsa049400.63586269
108Neurotrophin signaling pathway_Homo sapiens_hsa047220.62646630
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.62042966
110Viral carcinogenesis_Homo sapiens_hsa052030.61814342
111Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.61653531
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.61280485
113Thyroid cancer_Homo sapiens_hsa052160.61137063
114Hematopoietic cell lineage_Homo sapiens_hsa046400.60620449
115Nitrogen metabolism_Homo sapiens_hsa009100.60587743
116Sphingolipid signaling pathway_Homo sapiens_hsa040710.59846858
117Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59727903
118RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.59432562
119ECM-receptor interaction_Homo sapiens_hsa045120.58860667
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.57555919
121Arginine biosynthesis_Homo sapiens_hsa002200.57412203
122Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56420287
123Acute myeloid leukemia_Homo sapiens_hsa052210.55024532
124Prolactin signaling pathway_Homo sapiens_hsa049170.54708378
125Fructose and mannose metabolism_Homo sapiens_hsa000510.54049443
126Arginine and proline metabolism_Homo sapiens_hsa003300.52993864
127Sphingolipid metabolism_Homo sapiens_hsa006000.52169402
128Vibrio cholerae infection_Homo sapiens_hsa051100.51581740
129Histidine metabolism_Homo sapiens_hsa003400.51467531
130Bladder cancer_Homo sapiens_hsa052190.50658681
131Platelet activation_Homo sapiens_hsa046110.50446864
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49552741
133Toll-like receptor signaling pathway_Homo sapiens_hsa046200.49040507
134Non-homologous end-joining_Homo sapiens_hsa034500.48739770
135Influenza A_Homo sapiens_hsa051640.47483915
136MicroRNAs in cancer_Homo sapiens_hsa052060.47345249
137VEGF signaling pathway_Homo sapiens_hsa043700.47170670
138Pancreatic cancer_Homo sapiens_hsa052120.47110407
139Alcoholism_Homo sapiens_hsa050340.45660584
140Tuberculosis_Homo sapiens_hsa051520.45574950
141Epstein-Barr virus infection_Homo sapiens_hsa051690.45503515
142Phagosome_Homo sapiens_hsa041450.45377485
143Jak-STAT signaling pathway_Homo sapiens_hsa046300.44998933
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43623475

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