MGAT3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.58725420
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.49670722
3locomotory exploration behavior (GO:0035641)5.36008385
4vocalization behavior (GO:0071625)5.13242949
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11425001
6positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.01704717
7synaptic vesicle exocytosis (GO:0016079)4.73738385
8regulation of synaptic vesicle exocytosis (GO:2000300)4.72080940
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67574231
10glutamate secretion (GO:0014047)4.63543865
11neuronal action potential propagation (GO:0019227)4.41562028
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.31827864
13layer formation in cerebral cortex (GO:0021819)4.27132086
14regulation of glutamate receptor signaling pathway (GO:1900449)4.26287160
15neuron cell-cell adhesion (GO:0007158)4.19157775
16exploration behavior (GO:0035640)4.09834650
17regulation of synaptic vesicle transport (GO:1902803)4.09406228
18neurotransmitter secretion (GO:0007269)4.09179215
19ionotropic glutamate receptor signaling pathway (GO:0035235)4.07600684
20gamma-aminobutyric acid transport (GO:0015812)4.06735665
21regulation of neuronal synaptic plasticity (GO:0048168)3.96210555
22protein localization to synapse (GO:0035418)3.95649290
23dendritic spine morphogenesis (GO:0060997)3.93842638
24cellular potassium ion homeostasis (GO:0030007)3.93411865
25amino acid import (GO:0043090)3.90022433
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.87892437
27sodium ion export (GO:0071436)3.83686196
28positive regulation of dendritic spine development (GO:0060999)3.83340530
29regulation of synapse maturation (GO:0090128)3.78774148
30synaptic transmission, glutamatergic (GO:0035249)3.73602585
31regulation of synapse structural plasticity (GO:0051823)3.68578567
32regulation of ARF protein signal transduction (GO:0032012)3.67353895
33proline transport (GO:0015824)3.62218066
34glutamate receptor signaling pathway (GO:0007215)3.58512047
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.56915640
36establishment of mitochondrion localization (GO:0051654)3.52427242
37positive regulation of dendritic spine morphogenesis (GO:0061003)3.51487403
38neuron-neuron synaptic transmission (GO:0007270)3.50219424
39regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.47502316
40G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.46907207
41positive regulation of membrane potential (GO:0045838)3.45935849
42long-term memory (GO:0007616)3.44936536
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.42272927
44neurotransmitter transport (GO:0006836)3.41369636
45dendrite morphogenesis (GO:0048813)3.36948701
46glycine transport (GO:0015816)3.35925726
47neurotransmitter-gated ion channel clustering (GO:0072578)3.35805179
48regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35688348
49regulation of voltage-gated calcium channel activity (GO:1901385)3.33471678
50neuromuscular process controlling balance (GO:0050885)3.32943302
51neuron recognition (GO:0008038)3.32881255
52transmission of nerve impulse (GO:0019226)3.28131206
53positive regulation of synapse maturation (GO:0090129)3.28057299
54regulation of dendritic spine morphogenesis (GO:0061001)3.25469719
55negative regulation of dendrite morphogenesis (GO:0050774)3.25364806
56regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.24755294
57activation of protein kinase A activity (GO:0034199)3.24476024
58cell differentiation in hindbrain (GO:0021533)3.21760466
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.19174229
60regulation of postsynaptic membrane potential (GO:0060078)3.18954988
61positive regulation of neurotransmitter transport (GO:0051590)3.18533143
62presynaptic membrane assembly (GO:0097105)3.17587230
63regulation of synaptic plasticity (GO:0048167)3.17269568
64cerebellar granule cell differentiation (GO:0021707)3.17076326
65adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.16064280
66mechanosensory behavior (GO:0007638)3.15619398
67establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.15144337
68mitochondrion transport along microtubule (GO:0047497)3.15144337
69axonal fasciculation (GO:0007413)3.13523517
70regulation of neurotransmitter secretion (GO:0046928)3.12940017
71cerebellar Purkinje cell differentiation (GO:0021702)3.12812140
72postsynaptic membrane organization (GO:0001941)3.12810233
73membrane hyperpolarization (GO:0060081)3.10897313
74synaptic vesicle endocytosis (GO:0048488)3.08799356
75regulation of neurotransmitter levels (GO:0001505)3.08160084
76cell migration in hindbrain (GO:0021535)3.08085805
77auditory behavior (GO:0031223)3.07693617
78neuronal ion channel clustering (GO:0045161)3.07119222
79presynaptic membrane organization (GO:0097090)3.06530220
80L-amino acid import (GO:0043092)3.04486912
81cell communication by electrical coupling (GO:0010644)3.01884745
82dopamine receptor signaling pathway (GO:0007212)3.00425782
83positive regulation of synaptic transmission, GABAergic (GO:0032230)3.00353941
84positive regulation of neurotransmitter secretion (GO:0001956)3.00336826
85long-term synaptic potentiation (GO:0060291)3.00210664
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.99056834
87potassium ion import (GO:0010107)2.97715121
88regulation of synaptic transmission (GO:0050804)2.96974682
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.96593281
90positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.94626508
91regulation of vesicle fusion (GO:0031338)2.94508564
92neuromuscular process controlling posture (GO:0050884)2.94334082
93positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.94259947
94vesicle transport along microtubule (GO:0047496)2.94088180
95response to auditory stimulus (GO:0010996)2.90815947
96regulation of neurotransmitter transport (GO:0051588)2.89374899
97dendritic spine organization (GO:0097061)2.88445786
98regulation of synaptic transmission, glutamatergic (GO:0051966)2.88000394
99synapse assembly (GO:0007416)2.84736042
100prepulse inhibition (GO:0060134)2.80479421
101potassium ion homeostasis (GO:0055075)2.80280870
102membrane depolarization (GO:0051899)2.80183846
103membrane depolarization during action potential (GO:0086010)2.79582582
104cytoskeletal anchoring at plasma membrane (GO:0007016)2.79285353
105cellular sodium ion homeostasis (GO:0006883)2.77588856
106negative regulation of synaptic transmission, GABAergic (GO:0032229)2.75784373
107axon ensheathment in central nervous system (GO:0032291)2.75453203
108central nervous system myelination (GO:0022010)2.75453203
109neuromuscular process (GO:0050905)2.74259056
110mating behavior (GO:0007617)2.73900160
111synapse organization (GO:0050808)2.73695542
112adult walking behavior (GO:0007628)2.73531117
113organelle transport along microtubule (GO:0072384)2.73504561
114innervation (GO:0060384)2.73425593
115regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.72989446
116cerebellar Purkinje cell layer development (GO:0021680)2.72853983
117response to pheromone (GO:0019236)2.71101691
118learning (GO:0007612)2.70265422
119regulation of dendritic spine development (GO:0060998)2.69807470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.80816337
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.01361568
3GBX2_23144817_ChIP-Seq_PC3_Human3.00507620
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.98703037
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.86333875
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.73345148
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.73345148
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.67951392
9DROSHA_22980978_ChIP-Seq_HELA_Human2.58645637
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.56756535
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50722147
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48912967
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.47025511
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.44374791
15* RARB_27405468_Chip-Seq_BRAIN_Mouse2.41666273
16* REST_21632747_ChIP-Seq_MESCs_Mouse2.40619873
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39771441
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.36841552
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.26758149
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.24963194
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24652861
22RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.16626500
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.13264552
24* REST_18959480_ChIP-ChIP_MESCs_Mouse1.99237498
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97528825
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.92852484
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.92154991
28ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.89792994
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.79710908
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77606306
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75700554
32* LXR_22292898_ChIP-Seq_THP-1_Human1.73987888
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.66436533
34AR_21572438_ChIP-Seq_LNCaP_Human1.63732331
35KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59639331
36CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58006162
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50780794
38GATA1_26923725_Chip-Seq_HPCs_Mouse1.49991131
39SMAD4_21799915_ChIP-Seq_A2780_Human1.41794585
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.36552839
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36436345
42OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.35441206
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.35375983
44ZNF274_21170338_ChIP-Seq_K562_Hela1.32450522
45CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31799644
46WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31178860
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29743712
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29674878
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.29174772
50SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28908748
51EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.27893318
52SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26365437
53SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26064985
54* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24908545
55SOX2_21211035_ChIP-Seq_LN229_Gbm1.24902467
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23501429
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.22418742
58NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22279168
59TAF15_26573619_Chip-Seq_HEK293_Human1.21733389
60KDM2B_26808549_Chip-Seq_K562_Human1.21614213
61RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20751101
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.19679209
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18171722
64* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18030797
65SMAD3_21741376_ChIP-Seq_EPCs_Human1.17852488
66KDM2B_26808549_Chip-Seq_DND41_Human1.17021811
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.16036529
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15503442
69AHR_22903824_ChIP-Seq_MCF-7_Human1.15139613
70* AR_19668381_ChIP-Seq_PC3_Human1.14978493
71TP53_20018659_ChIP-ChIP_R1E_Mouse1.14845696
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14640946
73SMC4_20622854_ChIP-Seq_HELA_Human1.14108971
74OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14060545
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.13843729
76SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12279345
77STAT3_23295773_ChIP-Seq_U87_Human1.11545329
78ZFP281_18757296_ChIP-ChIP_E14_Mouse1.11369722
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.10678361
80TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08886514
81OCT4_19829295_ChIP-Seq_ESCs_Human1.08343924
82AR_25329375_ChIP-Seq_VCAP_Human1.07541366
83CBX2_27304074_Chip-Seq_ESCs_Mouse1.06606287
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06318692
85P300_19829295_ChIP-Seq_ESCs_Human1.04613368
86* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.04573745
87TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04073830
88CREB1_26743006_Chip-Seq_LNCaP_Human1.04056888
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03109515
90TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01989798
91ZFP57_27257070_Chip-Seq_ESCs_Mouse1.01352697
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01268880
93GATA1_19941826_ChIP-Seq_K562_Human1.00931394
94P68_20966046_ChIP-Seq_HELA_Human1.00481412
95YAP1_20516196_ChIP-Seq_MESCs_Mouse1.00473796
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98464723
97SMAD4_21741376_ChIP-Seq_HESCs_Human0.98397403
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.98305100
99ESR1_20079471_ChIP-ChIP_T-47D_Human0.97471958
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.96169308
101* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94386455
102AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93414175
103MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93255575
104TCF4_23295773_ChIP-Seq_U87_Human0.93119571
105SMAD3_21741376_ChIP-Seq_ESCs_Human0.92401764
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92176077
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.91890228
108RNF2_27304074_Chip-Seq_NSC_Mouse0.91697580
109ESR2_21235772_ChIP-Seq_MCF-7_Human0.90688147
110TET1_21490601_ChIP-Seq_MESCs_Mouse0.90566323
111TP53_16413492_ChIP-PET_HCT116_Human0.90112442
112DPY_21335234_ChIP-Seq_ESCs_Mouse0.89138538
113SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89095233
114MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.88580884
115CTCF_27219007_Chip-Seq_Bcells_Human0.88239552
116RXR_22108803_ChIP-Seq_LS180_Human0.88201613
117RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87951631
118* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87222460
119EP300_21415370_ChIP-Seq_HL-1_Mouse0.87170240
120SA1_27219007_Chip-Seq_ERYTHROID_Human0.87011742
121ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86141644
122GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85808268
123GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85576069
124TET1_21451524_ChIP-Seq_MESCs_Mouse0.84823713
125PRDM14_20953172_ChIP-Seq_ESCs_Human0.84038730
126SA1_27219007_Chip-Seq_Bcells_Human0.83873864
127KLF4_19829295_ChIP-Seq_ESCs_Human0.83567010
128* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83311839
129RUNX2_22187159_ChIP-Seq_PCA_Human0.82983610
130* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82777846
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.81634453
132* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.81505465
133SMAD4_21741376_ChIP-Seq_ESCs_Human0.81004805
134KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79697643
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.79313439
136TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.77743059
137NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.76121595
138TCF7_22412390_ChIP-Seq_EML_Mouse0.75573496
139CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75168937
140GATA1_19941827_ChIP-Seq_MEL_Mouse0.74856754
141MYC_27129775_Chip-Seq_CORNEA_Mouse0.74856396
142CTCF_27219007_Chip-Seq_ERYTHROID_Human0.73864550

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.05041385
2MP0003880_abnormal_central_pattern4.33548953
3MP0004270_analgesia3.92322856
4MP0003635_abnormal_synaptic_transmissio3.86879752
5MP0005423_abnormal_somatic_nervous3.27869196
6MP0009745_abnormal_behavioral_response3.09074600
7MP0002063_abnormal_learning/memory/cond3.06082696
8MP0002064_seizures2.96727958
9MP0009046_muscle_twitch2.94350781
10MP0001968_abnormal_touch/_nociception2.73628714
11MP0002734_abnormal_mechanical_nocicepti2.68460875
12MP0002272_abnormal_nervous_system2.57343117
13MP0009780_abnormal_chondrocyte_physiolo2.53516809
14MP0002572_abnormal_emotion/affect_behav2.53118986
15MP0001486_abnormal_startle_reflex2.48082172
16MP0002822_catalepsy2.42104002
17MP0004147_increased_porphyrin_level2.32779935
18MP0002736_abnormal_nociception_after2.06847083
19MP0001501_abnormal_sleep_pattern2.05862365
20MP0008569_lethality_at_weaning2.05772827
21MP0002735_abnormal_chemical_nociception2.03036144
22MP0003329_amyloid_beta_deposits2.01723368
23MP0002733_abnormal_thermal_nociception2.01283132
24MP0004885_abnormal_endolymph2.00246255
25MP0000778_abnormal_nervous_system1.99453254
26MP0001440_abnormal_grooming_behavior1.96483538
27MP0004858_abnormal_nervous_system1.93972863
28MP0001970_abnormal_pain_threshold1.90146383
29MP0002067_abnormal_sensory_capabilities1.90111679
30MP0002909_abnormal_adrenal_gland1.89374096
31MP0002184_abnormal_innervation1.75639008
32MP0000566_synostosis1.72440916
33MP0004811_abnormal_neuron_physiology1.71588917
34MP0000955_abnormal_spinal_cord1.64768268
35MP0002557_abnormal_social/conspecific_i1.62004527
36MP0005386_behavior/neurological_phenoty1.60260505
37MP0004924_abnormal_behavior1.60260505
38MP0004043_abnormal_pH_regulation1.53533519
39MP0003123_paternal_imprinting1.49794845
40MP0003283_abnormal_digestive_organ1.45054585
41MP0002882_abnormal_neuron_morphology1.44674618
42MP0003879_abnormal_hair_cell1.44537602
43MP0002066_abnormal_motor_capabilities/c1.42825414
44MP0003633_abnormal_nervous_system1.39801029
45MP0005646_abnormal_pituitary_gland1.34292475
46MP0000920_abnormal_myelination1.34242580
47MP0001984_abnormal_olfaction1.31837935
48MP0009379_abnormal_foot_pigmentation1.31080768
49MP0006276_abnormal_autonomic_nervous1.28662186
50MP0010234_abnormal_vibrissa_follicle1.27533273
51MP0003631_nervous_system_phenotype1.20541338
52MP0003690_abnormal_glial_cell1.17679755
53MP0004142_abnormal_muscle_tone1.14120836
54MP0003634_abnormal_glial_cell1.13191422
55MP0002152_abnormal_brain_morphology1.11519344
56MP0005645_abnormal_hypothalamus_physiol1.10571676
57MP0004742_abnormal_vestibular_system1.08494278
58MP0003787_abnormal_imprinting1.07446993
59MP0002229_neurodegeneration1.04696524
60MP0003122_maternal_imprinting1.04301450
61MP0001346_abnormal_lacrimal_gland1.04085598
62MP0001905_abnormal_dopamine_level1.03410558
63MP0001485_abnormal_pinna_reflex1.02261008
64MP0003632_abnormal_nervous_system1.00949810
65MP0001529_abnormal_vocalization1.00591043
66MP0002638_abnormal_pupillary_reflex1.00008647
67MP0001177_atelectasis0.97190933
68MP0001502_abnormal_circadian_rhythm0.97006877
69MP0000013_abnormal_adipose_tissue0.96232880
70MP0001348_abnormal_lacrimal_gland0.92998106
71MP0008872_abnormal_physiological_respon0.92542998
72MP0002069_abnormal_eating/drinking_beha0.92097916
73MP0005623_abnormal_meninges_morphology0.91536928
74MP0001963_abnormal_hearing_physiology0.90314403
75MP0008961_abnormal_basal_metabolism0.90068919
76MP0004145_abnormal_muscle_electrophysio0.88221739
77MP0005499_abnormal_olfactory_system0.87069264
78MP0005394_taste/olfaction_phenotype0.87069264
79MP0005670_abnormal_white_adipose0.86763531
80MP0010386_abnormal_urinary_bladder0.86574143
81MP0001299_abnormal_eye_distance/0.86382352
82MP0003938_abnormal_ear_development0.83837373
83MP0001664_abnormal_digestion0.83552384
84MP0001986_abnormal_taste_sensitivity0.82205322
85MP0000569_abnormal_digit_pigmentation0.81840146
86MP0000751_myopathy0.80905955
87MP0003183_abnormal_peptide_metabolism0.80027104
88MP0002752_abnormal_somatic_nervous0.77793322
89MP0005167_abnormal_blood-brain_barrier0.77475238
90MP0000631_abnormal_neuroendocrine_gland0.76284869
91MP0001188_hyperpigmentation0.74888041
92MP0002249_abnormal_larynx_morphology0.74048419
93MP0000604_amyloidosis0.73515660
94MP0003075_altered_response_to0.73209453
95MP0005551_abnormal_eye_electrophysiolog0.72892172
96MP0004130_abnormal_muscle_cell0.72581298
97MP0000534_abnormal_ureter_morphology0.72018147
98MP0004085_abnormal_heartbeat0.71050433
99MP0000537_abnormal_urethra_morphology0.68064981
100MP0005409_darkened_coat_color0.67806951
101MP0002082_postnatal_lethality0.65879475
102MP0010770_preweaning_lethality0.65879475
103MP0008874_decreased_physiological_sensi0.65717086
104MP0010768_mortality/aging0.64710061
105MP0003861_abnormal_nervous_system0.64437641
106MP0003121_genomic_imprinting0.63491147
107MP0001943_abnormal_respiration0.62013043
108MP0001765_abnormal_ion_homeostasis0.61218685
109MP0004484_altered_response_of0.60355558
110MP0002089_abnormal_postnatal_growth/wei0.59502779
111MP0004233_abnormal_muscle_weight0.58958975
112MP0005535_abnormal_body_temperature0.58775112
113MP0002234_abnormal_pharynx_morphology0.58015821
114MP0003137_abnormal_impulse_conducting0.56583431
115MP0000462_abnormal_digestive_system0.56165488
116MP0003878_abnormal_ear_physiology0.56162637
117MP0005377_hearing/vestibular/ear_phenot0.56162637
118MP0010769_abnormal_survival0.54298520
119MP0000026_abnormal_inner_ear0.53784211
120MP0002090_abnormal_vision0.52845084
121MP0003956_abnormal_body_size0.51988913
122MP0005448_abnormal_energy_balance0.49622144
123* MP0002873_normal_phenotype0.49472931
124* MP0002169_no_abnormal_phenotype0.48404218

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.37359680
2Focal motor seizures (HP:0011153)6.12171841
3Focal seizures (HP:0007359)4.75749868
4Action tremor (HP:0002345)4.56293483
5Visual hallucinations (HP:0002367)4.54812089
6Epileptic encephalopathy (HP:0200134)4.00787013
7Progressive cerebellar ataxia (HP:0002073)3.90543582
8Atonic seizures (HP:0010819)3.83870931
9Supranuclear gaze palsy (HP:0000605)3.61339729
10Ankle clonus (HP:0011448)3.55989359
11Febrile seizures (HP:0002373)3.36457209
12Absence seizures (HP:0002121)3.28129772
13Broad-based gait (HP:0002136)3.12084845
14Insidious onset (HP:0003587)3.08278051
15Termporal pattern (HP:0011008)3.08278051
16Generalized tonic-clonic seizures (HP:0002069)3.05639822
17Dialeptic seizures (HP:0011146)2.98002974
18Dysmetria (HP:0001310)2.97221293
19Megalencephaly (HP:0001355)2.97209256
20Depression (HP:0000716)2.97134663
21Intention tremor (HP:0002080)2.96760377
22Neurofibrillary tangles (HP:0002185)2.91204584
23Abnormal eating behavior (HP:0100738)2.91111504
24Scanning speech (HP:0002168)2.89104168
25Dysdiadochokinesis (HP:0002075)2.88678651
26Poor eye contact (HP:0000817)2.85459260
27Abnormality of the corticospinal tract (HP:0002492)2.85220995
28Gaze-evoked nystagmus (HP:0000640)2.85047531
29Increased circulating renin level (HP:0000848)2.79061870
30Impaired vibration sensation in the lower limbs (HP:0002166)2.76652295
31Status epilepticus (HP:0002133)2.76550559
32Spastic gait (HP:0002064)2.76494153
33Cerebral inclusion bodies (HP:0100314)2.69832261
34Abnormal social behavior (HP:0012433)2.69109793
35Impaired social interactions (HP:0000735)2.69109793
36Anxiety (HP:0000739)2.68922455
37Urinary urgency (HP:0000012)2.68054233
38Urinary bladder sphincter dysfunction (HP:0002839)2.63700463
39Mutism (HP:0002300)2.63098429
40Postural instability (HP:0002172)2.62783948
41Aplasia involving bones of the upper limbs (HP:0009823)2.61954845
42Aplasia of the phalanges of the hand (HP:0009802)2.61954845
43Aplasia involving bones of the extremities (HP:0009825)2.61954845
44Pheochromocytoma (HP:0002666)2.60523985
45Truncal ataxia (HP:0002078)2.59887300
46Genetic anticipation (HP:0003743)2.50569849
47Ventricular fibrillation (HP:0001663)2.50557132
48Hyperventilation (HP:0002883)2.49135163
49Amblyopia (HP:0000646)2.49011564
50Papilledema (HP:0001085)2.47076348
51Cerebral hypomyelination (HP:0006808)2.42720729
52Sleep apnea (HP:0010535)2.40684328
53Tetraplegia (HP:0002445)2.38068269
54Torticollis (HP:0000473)2.34352180
55Drooling (HP:0002307)2.33307684
56Excessive salivation (HP:0003781)2.33307684
57Hemiparesis (HP:0001269)2.32051197
58Hemiplegia (HP:0002301)2.30794375
59Metabolic alkalosis (HP:0200114)2.29309457
60Spastic tetraparesis (HP:0001285)2.20681220
61Apathy (HP:0000741)2.19240794
62Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18938265
63Degeneration of the lateral corticospinal tracts (HP:0002314)2.18938265
64Impaired smooth pursuit (HP:0007772)2.18626314
65Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.18372039
66Abnormality of the lower motor neuron (HP:0002366)2.17686697
67Diplopia (HP:0000651)2.17612944
68Abnormality of binocular vision (HP:0011514)2.17612944
69Lower limb muscle weakness (HP:0007340)2.16566659
70Stereotypic behavior (HP:0000733)2.13287152
71Focal dystonia (HP:0004373)2.13163231
72Bradykinesia (HP:0002067)2.09131574
73Turricephaly (HP:0000262)2.08171089
74Neuroendocrine neoplasm (HP:0100634)2.07761907
75Insomnia (HP:0100785)2.07186785
76Delusions (HP:0000746)2.06077400
77Agitation (HP:0000713)2.02491090
78Epileptiform EEG discharges (HP:0011182)2.01616772
79Annular pancreas (HP:0001734)2.00708152
80Limb dystonia (HP:0002451)2.00688022
81Dysmetric saccades (HP:0000641)2.00607051
82Morphological abnormality of the pyramidal tract (HP:0002062)2.00383455
83Postural tremor (HP:0002174)2.00204166
84Clonus (HP:0002169)1.99641955
85EEG with generalized epileptiform discharges (HP:0011198)1.98257859
86Peripheral hypomyelination (HP:0007182)1.98084500
87Bronchomalacia (HP:0002780)1.97125228
88Rigidity (HP:0002063)1.96088101
89Bundle branch block (HP:0011710)1.95244344
90Diminished motivation (HP:0000745)1.94947852
91Fetal akinesia sequence (HP:0001989)1.94450604
92Confusion (HP:0001289)1.93617874
93Hypsarrhythmia (HP:0002521)1.93209705
94Onion bulb formation (HP:0003383)1.92819090
95Craniofacial dystonia (HP:0012179)1.92462070
96Akinesia (HP:0002304)1.90433697
97Progressive inability to walk (HP:0002505)1.88508771
98Abnormality of ocular smooth pursuit (HP:0000617)1.86916045
99Lower limb asymmetry (HP:0100559)1.85120202
100Hyperacusis (HP:0010780)1.84360291
101Neuronal loss in central nervous system (HP:0002529)1.84258058
102Gait ataxia (HP:0002066)1.82988320
103Polyphagia (HP:0002591)1.82504636
104Pointed chin (HP:0000307)1.80700017
105Incomplete penetrance (HP:0003829)1.79818540
106Hyperthyroidism (HP:0000836)1.79149954
107Hypokalemic alkalosis (HP:0001949)1.77503051
108Truncus arteriosus (HP:0001660)1.77211356
109Ankyloglossia (HP:0010296)1.76036482
110Obstructive sleep apnea (HP:0002870)1.75975956
111Spinal canal stenosis (HP:0003416)1.75731652
112Resting tremor (HP:0002322)1.74741497
113Impaired vibratory sensation (HP:0002495)1.74523867
114Neoplasm of the peripheral nervous system (HP:0100007)1.74280555
115Absent speech (HP:0001344)1.73663769
116Amyotrophic lateral sclerosis (HP:0007354)1.73577714
117Thickened helices (HP:0000391)1.73500218
118Rapidly progressive (HP:0003678)1.72202700
119Hyperactive renin-angiotensin system (HP:0000841)1.72201097
120Overriding aorta (HP:0002623)1.71334414
121Abnormality of saccadic eye movements (HP:0000570)1.71072977
122Choreoathetosis (HP:0001266)1.70603951
123Deep palmar crease (HP:0006191)1.68865934
124CNS hypomyelination (HP:0003429)1.64544817

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.83791108
2MAP3K93.54563840
3EPHA43.34060021
4MARK13.04638151
5MAP3K42.58669650
6MINK12.58563772
7PAK62.34272977
8DAPK22.29759596
9PRKD32.28778891
10NTRK12.21658343
11KSR22.20170573
12OXSR12.11340988
13NTRK21.86364727
14MAP2K71.83773418
15CDK191.77726340
16MAP3K21.73944508
17CAMKK11.69789058
18MAP2K41.58879280
19STK391.55779899
20CDK51.54539642
21MAP3K121.38805866
22UHMK11.38167395
23KSR11.38085462
24SGK4941.37017630
25SGK2231.37017630
26TYRO31.36038771
27WNK41.35142947
28STK381.34322557
29WNK11.32391470
30LMTK21.32249370
31CASK1.26807865
32RIPK41.18336964
33PNCK1.15996200
34WNK31.14803115
35TNIK1.14752017
36PRPF4B1.11309374
37GRK51.09451787
38MAPK131.04917517
39BRAF1.03346716
40PLK21.03270920
41MAPK121.02927719
42PRKCG1.02856506
43PHKG11.02458997
44PHKG21.02458997
45DAPK11.01594344
46PAK31.00884685
47EEF2K0.98907328
48MAP3K100.98174519
49CAMKK20.96449059
50RET0.95138791
51CDK150.94248778
52LATS20.93692791
53CAMK2B0.93547786
54TRIB30.93340412
55CDK180.93228271
56TAOK10.93228229
57ARAF0.92876128
58STK110.92674759
59CDK140.91888885
60PRKCH0.90556611
61DYRK20.90317190
62RIPK10.88942450
63CAMK2A0.87562213
64SGK20.85727474
65PKN10.83897954
66SGK30.83614353
67ALK0.83077414
68CDK11A0.82020587
69SIK20.81488353
70CSNK1G20.78201391
71MARK20.75910541
72PINK10.72528996
73CAMK10.72309221
74MAP3K110.71245975
75PDPK10.71236064
76DDR20.70830243
77SGK10.68598335
78FGFR20.68269961
79DYRK1A0.67967389
80FES0.67258215
81FER0.67193588
82ROCK20.65878242
83LIMK10.64951481
84CAMK2D0.61902362
85MAP3K130.61792756
86PDK10.60819218
87CDC42BPA0.60649283
88CAMK40.60496650
89CAMK2G0.57842251
90NEK60.57250178
91MAP3K10.55975910
92ICK0.55091476
93PTK2B0.54842283
94MAP2K10.53499501
95PRKCE0.53112367
96FYN0.52725029
97PRKCZ0.51319278
98BCR0.49636709
99DAPK30.47333957
100NME10.47192491
101RPS6KA30.47165851
102PTK20.46307518
103MAPK40.45431679
104CAMK1D0.44509700
105MAPKAPK50.44407178
106SCYL20.43257512
107BRSK10.43223757
108RPS6KA20.43136098
109MAP3K70.42923862
110MAPK100.42225860
111EPHB20.41149884
112CAMK1G0.41020119
113SMG10.40178306
114CCNB10.39406049
115DYRK1B0.34442594
116MAPK80.34022343
117GSK3B0.33650346
118JAK20.30478076
119ERBB20.29685362
120PRKCA0.29339473
121TAOK20.28910532
122SYK0.26536315

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.11630688
2Synaptic vesicle cycle_Homo sapiens_hsa047213.05525572
3GABAergic synapse_Homo sapiens_hsa047272.48225796
4Circadian entrainment_Homo sapiens_hsa047132.42198043
5Long-term potentiation_Homo sapiens_hsa047202.39485897
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.37935365
7Glutamatergic synapse_Homo sapiens_hsa047242.35703568
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34460268
9Olfactory transduction_Homo sapiens_hsa047402.33004913
10Morphine addiction_Homo sapiens_hsa050322.15898857
11Amphetamine addiction_Homo sapiens_hsa050312.15129292
12Salivary secretion_Homo sapiens_hsa049702.11188370
13Gastric acid secretion_Homo sapiens_hsa049712.02775538
14Insulin secretion_Homo sapiens_hsa049111.96306475
15Dopaminergic synapse_Homo sapiens_hsa047281.94935623
16Cholinergic synapse_Homo sapiens_hsa047251.76100399
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.70269484
18Long-term depression_Homo sapiens_hsa047301.68741018
19Taste transduction_Homo sapiens_hsa047421.67737213
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.67571055
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63932128
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.62210394
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56958534
24Cocaine addiction_Homo sapiens_hsa050301.55179715
25Renin secretion_Homo sapiens_hsa049241.52578840
26Collecting duct acid secretion_Homo sapiens_hsa049661.46814886
27Serotonergic synapse_Homo sapiens_hsa047261.42685219
28Oxytocin signaling pathway_Homo sapiens_hsa049211.41867228
29Gap junction_Homo sapiens_hsa045401.39615935
30GnRH signaling pathway_Homo sapiens_hsa049121.35485316
31Axon guidance_Homo sapiens_hsa043601.31359707
32Calcium signaling pathway_Homo sapiens_hsa040201.27252483
33Type II diabetes mellitus_Homo sapiens_hsa049301.23751714
34Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20993239
35Estrogen signaling pathway_Homo sapiens_hsa049151.15553550
36Nitrogen metabolism_Homo sapiens_hsa009101.15286786
37cAMP signaling pathway_Homo sapiens_hsa040241.14925283
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.14353898
39Vibrio cholerae infection_Homo sapiens_hsa051101.06942045
40Glioma_Homo sapiens_hsa052141.06432624
41Melanogenesis_Homo sapiens_hsa049161.04412251
42ErbB signaling pathway_Homo sapiens_hsa040121.02609744
43Dorso-ventral axis formation_Homo sapiens_hsa043201.01789421
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.00000429
45Pancreatic secretion_Homo sapiens_hsa049720.97144879
46Thyroid hormone synthesis_Homo sapiens_hsa049180.95655045
47Carbohydrate digestion and absorption_Homo sapiens_hsa049730.95504114
48Vitamin B6 metabolism_Homo sapiens_hsa007500.94503756
49cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94186363
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.89933085
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.87473388
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.84607805
53Bile secretion_Homo sapiens_hsa049760.80315497
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.77590626
55Choline metabolism in cancer_Homo sapiens_hsa052310.76592960
56Cardiac muscle contraction_Homo sapiens_hsa042600.75942924
57Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.73938544
58Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.73737235
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71176248
60Protein digestion and absorption_Homo sapiens_hsa049740.69827123
61Oocyte meiosis_Homo sapiens_hsa041140.67397828
62Fatty acid biosynthesis_Homo sapiens_hsa000610.67365223
63Mineral absorption_Homo sapiens_hsa049780.66956264
64Butanoate metabolism_Homo sapiens_hsa006500.66924625
65Histidine metabolism_Homo sapiens_hsa003400.66769923
66Dilated cardiomyopathy_Homo sapiens_hsa054140.66734068
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65663589
68MAPK signaling pathway_Homo sapiens_hsa040100.64242706
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.64023501
70Endocytosis_Homo sapiens_hsa041440.62934435
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.62834141
72Renal cell carcinoma_Homo sapiens_hsa052110.59924176
73Endometrial cancer_Homo sapiens_hsa052130.58449761
74Ras signaling pathway_Homo sapiens_hsa040140.57771541
75Rap1 signaling pathway_Homo sapiens_hsa040150.57487174
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57060407
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.56940446
78Inositol phosphate metabolism_Homo sapiens_hsa005620.56905755
79B cell receptor signaling pathway_Homo sapiens_hsa046620.56768711
80Tight junction_Homo sapiens_hsa045300.56571636
81Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55653472
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.55573015
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.54913589
84Arginine biosynthesis_Homo sapiens_hsa002200.54256312
85VEGF signaling pathway_Homo sapiens_hsa043700.53211670
86AMPK signaling pathway_Homo sapiens_hsa041520.51786700
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51106853
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.51014702
89Arginine and proline metabolism_Homo sapiens_hsa003300.49255545
90Wnt signaling pathway_Homo sapiens_hsa043100.47774575
91Phototransduction_Homo sapiens_hsa047440.47697337
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47064604
93mTOR signaling pathway_Homo sapiens_hsa041500.46552127
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.46115549
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.44890292
96Hedgehog signaling pathway_Homo sapiens_hsa043400.44360012
97Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.43453312
98Glucagon signaling pathway_Homo sapiens_hsa049220.41644133
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40406095
100Non-small cell lung cancer_Homo sapiens_hsa052230.38654742
101Alcoholism_Homo sapiens_hsa050340.37816176
102Prion diseases_Homo sapiens_hsa050200.37093241
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.36615025
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.36578342
105Circadian rhythm_Homo sapiens_hsa047100.35707752
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34912053
107Hippo signaling pathway_Homo sapiens_hsa043900.34279324
108Ovarian steroidogenesis_Homo sapiens_hsa049130.34115689
109Renin-angiotensin system_Homo sapiens_hsa046140.33643472
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.32773820
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32746458
112Insulin signaling pathway_Homo sapiens_hsa049100.32414328
113Prolactin signaling pathway_Homo sapiens_hsa049170.31457848
114Sulfur metabolism_Homo sapiens_hsa009200.29971283
115Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28501003

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