MGAT4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03065274
2negative T cell selection (GO:0043383)4.74336165
3negative thymic T cell selection (GO:0045060)4.51223278
4regulation of gamma-delta T cell differentiation (GO:0045586)4.35153632
5positive regulation by symbiont of host defense response (GO:0052509)4.18865012
6modulation by symbiont of host defense response (GO:0052031)4.18865012
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.18865012
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.18865012
9positive regulation by organism of defense response of other organism involved in symbiotic interact4.18865012
10modulation by symbiont of host immune response (GO:0052553)4.18865012
11macrophage activation involved in immune response (GO:0002281)4.14666192
12microglial cell activation (GO:0001774)3.96698090
13hepatocyte apoptotic process (GO:0097284)3.94970343
14positive T cell selection (GO:0043368)3.93910393
15response to interleukin-15 (GO:0070672)3.81037324
16regulation of interferon-beta biosynthetic process (GO:0045357)3.80282714
17angiotensin maturation (GO:0002003)3.80024480
18T cell selection (GO:0045058)3.64806705
19maintenance of gastrointestinal epithelium (GO:0030277)3.64269293
20positive thymic T cell selection (GO:0045059)3.63233403
21activated T cell proliferation (GO:0050798)3.60667990
22cellular response to interleukin-15 (GO:0071350)3.58287393
23negative regulation of lymphocyte mediated immunity (GO:0002707)3.32438431
24thymic T cell selection (GO:0045061)3.29899840
25intestinal absorption (GO:0050892)3.25496391
26negative regulation of T cell mediated immunity (GO:0002710)3.25024445
27regulation of T cell mediated cytotoxicity (GO:0001914)3.23770556
28regulation of chemokine secretion (GO:0090196)3.16036137
29response to host immune response (GO:0052572)3.07697556
30response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07697556
31regulation of B cell receptor signaling pathway (GO:0050855)3.06947597
32positive regulation of interferon-alpha production (GO:0032727)3.05331538
33negative regulation of interleukin-12 production (GO:0032695)3.04463033
34response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.02039335
35response to host (GO:0075136)3.02039335
36response to host defenses (GO:0052200)3.02039335
37negative regulation of leukocyte mediated immunity (GO:0002704)3.01339048
38macrophage activation (GO:0042116)2.99457803
39regulation of regulatory T cell differentiation (GO:0045589)2.99045529
40regulation of leukocyte mediated cytotoxicity (GO:0001910)2.97731658
41cellular extravasation (GO:0045123)2.96849804
42histamine secretion (GO:0001821)2.96410074
43antigen processing and presentation of endogenous antigen (GO:0019883)2.95593175
44positive regulation of T cell mediated cytotoxicity (GO:0001916)2.94877701
45neutrophil activation involved in immune response (GO:0002283)2.94682481
46interferon-gamma production (GO:0032609)2.94471604
47T cell migration (GO:0072678)2.94114917
48positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.91856831
49cellular response to ethanol (GO:0071361)2.88747459
50neutrophil activation (GO:0042119)2.88521121
51antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.88191952
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.88191952
53regulation of interferon-alpha production (GO:0032647)2.88068878
54regulation of activation of Janus kinase activity (GO:0010533)2.86859363
55bundle of His cell to Purkinje myocyte communication (GO:0086069)2.85835434
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85741242
57intestinal cholesterol absorption (GO:0030299)2.85199157
58positive regulation of gamma-delta T cell activation (GO:0046645)2.85035050
59leukocyte aggregation (GO:0070486)2.84889036
60regulation of natural killer cell mediated immunity (GO:0002715)2.83727775
61regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.83727775
62lipoprotein transport (GO:0042953)2.82233644
63regulation of memory T cell differentiation (GO:0043380)2.80950801
64granulocyte activation (GO:0036230)2.80237933
65regulation of alpha-beta T cell proliferation (GO:0046640)2.80010158
66oligosaccharide catabolic process (GO:0009313)2.77455867
67hypotonic response (GO:0006971)2.77095551
68epithelial structure maintenance (GO:0010669)2.77060174
69monocyte chemotaxis (GO:0002548)2.76640567
70positive regulation of antigen processing and presentation (GO:0002579)2.75288541
71positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.75001050
72dendritic cell migration (GO:0036336)2.73692157
73regulation of germinal center formation (GO:0002634)2.71815044
74O-glycan processing (GO:0016266)2.71761384
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.71000127
76dendritic cell chemotaxis (GO:0002407)2.70440673
77regulation of cellular extravasation (GO:0002691)2.69698302
78antigen processing and presentation via MHC class Ib (GO:0002475)2.69023040
79myeloid cell activation involved in immune response (GO:0002275)2.68376176
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.68133783
81lipopolysaccharide-mediated signaling pathway (GO:0031663)2.67422802
82positive regulation of chemokine secretion (GO:0090197)2.67316596
83regulation of cell killing (GO:0031341)2.67060723
84glomerular epithelial cell development (GO:0072310)2.66883396
85positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.65755326
86T cell receptor signaling pathway (GO:0050852)2.64874794
87regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.63421976
88positive regulation of granulocyte differentiation (GO:0030854)2.63271762
89G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.63154118
90regulation of hypersensitivity (GO:0002883)2.62827431
91I-kappaB phosphorylation (GO:0007252)2.60931856
92UDP-N-acetylglucosamine metabolic process (GO:0006047)2.60851342
93regulation of T cell tolerance induction (GO:0002664)2.59902823
94positive regulation of tolerance induction (GO:0002645)2.59273552
95mast cell activation (GO:0045576)2.59269645
96tolerance induction (GO:0002507)2.58475810
97mature B cell differentiation (GO:0002335)2.57365547
98negative regulation of innate immune response (GO:0045824)2.57243927
99detection of molecule of bacterial origin (GO:0032490)2.56649836
100glomerular visceral epithelial cell development (GO:0072015)2.56437658
101thrombin receptor signaling pathway (GO:0070493)2.55865267
102negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.55322260
103detection of bacterium (GO:0016045)2.53998151
104B cell receptor signaling pathway (GO:0050853)2.53175463
105antigen receptor-mediated signaling pathway (GO:0050851)2.52981735
106regulation of tolerance induction (GO:0002643)2.52701356
107detection of external biotic stimulus (GO:0098581)2.52247200
108regulation of RIG-I signaling pathway (GO:0039535)2.51395209
109relaxation of cardiac muscle (GO:0055119)2.50826733
110regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.50417995
111interferon-gamma-mediated signaling pathway (GO:0060333)2.50171038
112regulation of podosome assembly (GO:0071801)2.49698167
113positive regulation of alpha-beta T cell proliferation (GO:0046641)2.49518901
114positive regulation of humoral immune response (GO:0002922)2.48840475
115negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.47983858
116macroautophagy (GO:0016236)2.47149332
117positive regulation of interleukin-12 production (GO:0032735)2.46187241
118response to peptidoglycan (GO:0032494)2.46106014
119positive regulation of cell killing (GO:0031343)2.43820667
120vitamin A metabolic process (GO:0006776)2.42831549
121phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.42805949
122regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.42313448
123intestinal epithelial cell development (GO:0060576)2.42162097
124negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.42121714
125negative regulation of cell killing (GO:0031342)2.42121714
126actin nucleation (GO:0045010)2.42005120
127positive regulation of cellular amide metabolic process (GO:0034250)2.41601576
128immunoglobulin mediated immune response (GO:0016064)2.41197706
129positive regulation of Cdc42 GTPase activity (GO:0043089)2.40907590
130regulation of gamma-delta T cell activation (GO:0046643)2.40095646
131negative regulation of protein autophosphorylation (GO:0031953)2.37978920
132negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.37163008
133regulation of isotype switching to IgG isotypes (GO:0048302)2.37006337
134type I interferon signaling pathway (GO:0060337)2.36617310
135cellular response to type I interferon (GO:0071357)2.36617310
136response to type I interferon (GO:0034340)2.36186873
137T cell costimulation (GO:0031295)2.35603737
138positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.35197687
139lymph node development (GO:0048535)2.34733373
140response to muramyl dipeptide (GO:0032495)2.34544748
141myeloid dendritic cell activation (GO:0001773)2.34335792
142positive regulation of interleukin-1 beta secretion (GO:0050718)2.33651187
143positive regulation of response to biotic stimulus (GO:0002833)2.32049670
144lymphocyte costimulation (GO:0031294)2.31945216
145positive regulation of B cell differentiation (GO:0045579)2.31632343
146regulation of fever generation (GO:0031620)2.31026758
147leukocyte cell-cell adhesion (GO:0007159)2.30424525
148negative regulation of bone resorption (GO:0045779)2.30142901
149positive regulation of heat generation (GO:0031652)2.30002453
150actin filament depolymerization (GO:0030042)2.28586901
151respiratory burst (GO:0045730)2.27873849
152interferon-gamma secretion (GO:0072643)2.26609537
153detection of other organism (GO:0098543)2.26560663
154Arp2/3 complex-mediated actin nucleation (GO:0034314)2.26408427
155myeloid leukocyte activation (GO:0002274)2.26316627
156myeloid dendritic cell differentiation (GO:0043011)2.25989099
157positive regulation of macrophage differentiation (GO:0045651)2.25967233
158hemidesmosome assembly (GO:0031581)2.24357186
159regulation of T cell receptor signaling pathway (GO:0050856)2.23865582
160digestive system process (GO:0022600)2.22812090
161positive regulation of p38MAPK cascade (GO:1900745)2.22160693
162regulation of dendritic cell antigen processing and presentation (GO:0002604)2.21439468
163histamine transport (GO:0051608)2.21105541

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.01808688
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.88166823
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.69311258
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.54037624
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.41318343
6IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.08218173
7BP1_19119308_ChIP-ChIP_Hs578T_Human2.94583385
8* CDX2_20551321_ChIP-Seq_CACO-2_Human2.89141653
9* IRF8_27001747_Chip-Seq_BMDM_Mouse2.78741365
10* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73235171
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.67293736
12* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.61814064
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.39542141
14NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.35545783
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.33464269
16* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17602820
17RUNX_20019798_ChIP-Seq_JUKART_Human2.12329054
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.98827766
19EGR1_19374776_ChIP-ChIP_THP-1_Human1.89695622
20MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85644789
21SOX2_20726797_ChIP-Seq_SW620_Human1.78451380
22* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77669631
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75886835
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.73894054
25ESR1_20079471_ChIP-ChIP_T-47D_Human1.71629666
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.71525281
27VDR_24787735_ChIP-Seq_THP-1_Human1.66569244
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.62416516
29FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.55406227
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.52988197
31GATA3_26560356_Chip-Seq_TH2_Human1.52828849
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.52133724
33SPI1_23127762_ChIP-Seq_K562_Human1.51874840
34* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.51282341
35ESR1_21235772_ChIP-Seq_MCF-7_Human1.49809400
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.49325522
37RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38711388
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.37783219
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.37681235
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.37585827
41RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.36650844
42GATA4_25053715_ChIP-Seq_YYC3_Human1.35426651
43MYB_26560356_Chip-Seq_TH2_Human1.35352813
44SCL_19346495_ChIP-Seq_HPC-7_Human1.35259278
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29792549
46PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.29461628
47* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.28650384
48* GATA6_25053715_ChIP-Seq_YYC3_Human1.28003121
49LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.26932280
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26236383
51LXR_22158963_ChIP-Seq_LIVER_Mouse1.26152947
52CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.24828218
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.24001693
54VDR_24763502_ChIP-Seq_THP-1_Human1.23622880
55* TCF4_18268006_ChIP-ChIP_LS174T_Human1.23620922
56* UTX_26944678_Chip-Seq_JUKART_Human1.22163263
57BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21370646
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21181333
59* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21152891
60GATA2_19941826_ChIP-Seq_K562_Human1.20364236
61TP53_16413492_ChIP-PET_HCT116_Human1.19854359
62KLF5_25053715_ChIP-Seq_YYC3_Human1.19001433
63SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.16901043
64SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.16901043
65AHR_22903824_ChIP-Seq_MCF-7_Human1.16713261
66CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15440249
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14177116
68EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13367583
69GATA1_19941826_ChIP-Seq_K562_Human1.11724780
70* PU_27001747_Chip-Seq_BMDM_Mouse1.10444198
71RUNX1_27514584_Chip-Seq_MCF-7_Human1.10434708
72* GATA1_19941827_ChIP-Seq_MEL_Mouse1.09707905
73RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.06581121
74PPARA_22158963_ChIP-Seq_LIVER_Mouse1.06483194
75* FOXA2_19822575_ChIP-Seq_HepG2_Human1.05871687
76CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04592769
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.03935848
78KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03721593
79ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03630351
80ARNT_22903824_ChIP-Seq_MCF-7_Human1.03130058
81STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02265054
82GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02204178
83GATA1_22025678_ChIP-Seq_K562_Human1.01592345
84RXR_22158963_ChIP-Seq_LIVER_Mouse1.00908275
85CTNNB1_20460455_ChIP-Seq_HCT116_Human0.99818448
86LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.99557727
87MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99470634
88MYB_26560356_Chip-Seq_TH1_Human0.99104447
89* CJUN_26792858_Chip-Seq_BT549_Human0.99102050
90GATA3_27048872_Chip-Seq_THYMUS_Human0.97557211
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97242981
92CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96870629
93* TCF7_22412390_ChIP-Seq_EML_Mouse0.96824943
94NR3C1_23031785_ChIP-Seq_PC12_Mouse0.96619866
95MAF_26560356_Chip-Seq_TH1_Human0.96393964
96JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96275425
97FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.95913151
98SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95873197
99* GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.95080522
100FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94503673
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.93750540
102E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93110532
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92772498
104* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.92292280
105GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92289531
106FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90562425
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.90289853
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89764979
109SMAD3_21741376_ChIP-Seq_HESCs_Human0.89636344
110SPI1_23547873_ChIP-Seq_NB4_Human0.89548522
111DROSHA_22980978_ChIP-Seq_HELA_Human0.89359582
112KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89349806
113SOX9_24532713_ChIP-Seq_HFSC_Mouse0.87197861
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.86016530
115MAF_26560356_Chip-Seq_TH2_Human0.84138870
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83454489
117TP63_23658742_ChIP-Seq_EP156T_Human0.82827047
118SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.82774317
119RXR_22108803_ChIP-Seq_LS180_Human0.82550332
120CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82489836
121CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.82043313
122* FLI1_27457419_Chip-Seq_LIVER_Mouse0.81894877
123THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.81434871
124BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81309382
125* SMRT_27268052_Chip-Seq_Bcells_Human0.80636753
126KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.80550700
127TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.80342491
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.80089881
129SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.79097080
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.78212557
131EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.76889762
132* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76763986
133* PCGF2_27294783_Chip-Seq_ESCs_Mouse0.76325095
134TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.75170008
135PCGF2_27294783_Chip-Seq_NPCs_Mouse0.71012430
136VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.70591356
137CDX2_22108803_ChIP-Seq_LS180_Human0.69862312
138TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.69717627
139GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.69528558

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.59757418
2MP0001835_abnormal_antigen_presentation3.36834800
3MP0001873_stomach_inflammation2.79709505
4MP0003183_abnormal_peptide_metabolism2.79255433
5MP0002148_abnormal_hypersensitivity_rea2.69175450
6MP0010155_abnormal_intestine_physiology2.68853557
7MP0006054_spinal_hemorrhage2.66844088
8MP0004264_abnormal_extraembryonic_tissu2.65777577
9MP0003866_abnormal_defecation2.56521483
10MP0009785_altered_susceptibility_to2.55928909
11MP0005360_urolithiasis2.55508026
12MP0003300_gastrointestinal_ulcer2.49612789
13MP0005671_abnormal_response_to2.47030720
14MP0003195_calcinosis2.42302545
15MP0002452_abnormal_antigen_presenting2.33274878
16MP0002419_abnormal_innate_immunity2.27230699
17MP0001666_abnormal_nutrient_absorption2.25369906
18MP0005000_abnormal_immune_tolerance2.25369585
19MP0001800_abnormal_humoral_immune2.20278367
20MP0006082_CNS_inflammation2.17068873
21MP0001790_abnormal_immune_system2.14907577
22MP0005387_immune_system_phenotype2.14907577
23MP0003303_peritoneal_inflammation2.12985003
24MP0003436_decreased_susceptibility_to2.12039611
25MP0001663_abnormal_digestive_system2.02216595
26MP0002723_abnormal_immune_serum2.02048240
27MP0001819_abnormal_immune_cell1.98991584
28MP0005025_abnormal_response_to1.96833212
29MP0002420_abnormal_adaptive_immunity1.94241219
30MP0005365_abnormal_bile_salt1.93287972
31MP0010352_gastrointestinal_tract_polyps1.90876439
32MP0005310_abnormal_salivary_gland1.89514225
33MP0004947_skin_inflammation1.88424962
34MP0002006_tumorigenesis1.88057341
35MP0005464_abnormal_platelet_physiology1.85755083
36MP0000685_abnormal_immune_system1.81271617
37MP0002166_altered_tumor_susceptibility1.76479669
38MP0000569_abnormal_digit_pigmentation1.76361594
39MP0000490_abnormal_crypts_of1.71528448
40MP0005167_abnormal_blood-brain_barrier1.67868901
41MP0005085_abnormal_gallbladder_physiolo1.64324718
42MP0005381_digestive/alimentary_phenotyp1.61889219
43MP0001845_abnormal_inflammatory_respons1.61766336
44MP0009840_abnormal_foam_cell1.58826652
45MP0001533_abnormal_skeleton_physiology1.55059137
46MP0002139_abnormal_hepatobiliary_system1.53380405
47MP0005058_abnormal_lysosome_morphology1.50245048
48MP0002405_respiratory_system_inflammati1.48906449
49MP0003453_abnormal_keratinocyte_physiol1.48163597
50MP0008004_abnormal_stomach_pH1.47513778
51MP0003724_increased_susceptibility_to1.46959608
52MP0000604_amyloidosis1.45500792
53MP0002277_abnormal_respiratory_mucosa1.45348358
54MP0005166_decreased_susceptibility_to1.40697340
55MP0003191_abnormal_cellular_cholesterol1.38545616
56MP0005174_abnormal_tail_pigmentation1.38182314
57MP0010329_abnormal_lipoprotein_level1.37914722
58MP0000858_altered_metastatic_potential1.36307954
59MP0000716_abnormal_immune_system1.34382041
60MP0000465_gastrointestinal_hemorrhage1.33768337
61MP0003690_abnormal_glial_cell1.33280041
62MP0001664_abnormal_digestion1.32104926
63MP0004510_myositis1.31944888
64MP0003828_pulmonary_edema1.25617878
65MP0002398_abnormal_bone_marrow1.25010503
66MP0002998_abnormal_bone_remodeling1.24530905
67MP0005076_abnormal_cell_differentiation1.24054090
68MP0002138_abnormal_hepatobiliary_system1.23423865
69MP0004381_abnormal_hair_follicle1.23168296
70MP0003045_fibrosis1.23162203
71MP0000538_abnormal_urinary_bladder1.21267675
72MP0000703_abnormal_thymus_morphology1.19837164
73MP0000462_abnormal_digestive_system1.19122067
74MP0000015_abnormal_ear_pigmentation1.18830800
75MP0003566_abnormal_cell_adhesion1.17654487
76MP0002009_preneoplasia1.16505486
77MP0003252_abnormal_bile_duct1.10166857
78MP0005075_abnormal_melanosome_morpholog1.09125855
79MP0000477_abnormal_intestine_morphology1.08300034
80MP0003448_altered_tumor_morphology1.08007855
81MP0003075_altered_response_to1.06065129
82MP0004019_abnormal_vitamin_homeostasis1.04685554
83MP0000372_irregular_coat_pigmentation1.04417069
84MP0002933_joint_inflammation1.03892789
85MP0002429_abnormal_blood_cell1.03668016
86MP0003763_abnormal_thymus_physiology1.02748088
87MP0003091_abnormal_cell_migration1.02527677
88MP0010678_abnormal_skin_adnexa1.01382838
89MP0008469_abnormal_protein_level1.01114701
90MP0001849_ear_inflammation0.98957101
91MP0004043_abnormal_pH_regulation0.98719751
92MP0000689_abnormal_spleen_morphology0.96819549
93MP0002693_abnormal_pancreas_physiology0.96405850
94MP0003329_amyloid_beta_deposits0.96034920
95MP0002254_reproductive_system_inflammat0.95446980
96MP0009333_abnormal_splenocyte_physiolog0.94310588
97MP0000343_altered_response_to0.94072505
98MP0002136_abnormal_kidney_physiology0.93968899
99MP0001501_abnormal_sleep_pattern0.93418828
100MP0009764_decreased_sensitivity_to0.93184952
101MP0009643_abnormal_urine_homeostasis0.93049991
102MP0002722_abnormal_immune_system0.92811982
103MP0003879_abnormal_hair_cell0.92224378
104MP0000371_diluted_coat_color0.91935334
105MP0000537_abnormal_urethra_morphology0.90371140
106MP0003172_abnormal_lysosome_physiology0.89943141
107MP0002876_abnormal_thyroid_physiology0.89031279
108* MP0002118_abnormal_lipid_homeostasis0.87686526
109MP0003868_abnormal_feces_composition0.87106757
110MP0009278_abnormal_bone_marrow0.86333412
111MP0005451_abnormal_body_composition0.86095260
112* MP0000609_abnormal_liver_physiology0.81282786
113MP0002909_abnormal_adrenal_gland0.80098593
114MP0002396_abnormal_hematopoietic_system0.79532911
115MP0008260_abnormal_autophagy0.79069661
116MP0005164_abnormal_response_to0.76329182
117MP0000249_abnormal_blood_vessel0.75846366
118MP0005397_hematopoietic_system_phenotyp0.75556565
119MP0001545_abnormal_hematopoietic_system0.75556565
120MP0001986_abnormal_taste_sensitivity0.75488046
121MP0000516_abnormal_urinary_system0.74994126
122MP0005367_renal/urinary_system_phenotyp0.74994126
123MP0009115_abnormal_fat_cell0.74549565
124MP0000920_abnormal_myelination0.73731401
125MP0005171_absent_coat_pigmentation0.73584774
126MP0004147_increased_porphyrin_level0.70958417
127MP0003656_abnormal_erythrocyte_physiolo0.70823782
128MP0000470_abnormal_stomach_morphology0.70526121
129MP0010307_abnormal_tumor_latency0.68548910
130MP0001851_eye_inflammation0.68349206
131MP0005390_skeleton_phenotype0.67708059
132MP0001765_abnormal_ion_homeostasis0.66355871
133MP0001881_abnormal_mammary_gland0.65903517
134MP0004883_abnormal_blood_vessel0.65293866

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)4.58151492
2Eczematoid dermatitis (HP:0000976)4.44854722
3Recurrent abscess formation (HP:0002722)4.36691275
4Abnormality of T cell number (HP:0011839)4.29646325
5Recurrent bacterial skin infections (HP:0005406)4.19232688
6Autoimmune thrombocytopenia (HP:0001973)4.02880051
7Chronic diarrhea (HP:0002028)3.97233404
8Retrobulbar optic neuritis (HP:0100654)3.73144485
9Optic neuritis (HP:0100653)3.73144485
10Orchitis (HP:0100796)3.53744556
11Myositis (HP:0100614)3.43051527
12Pustule (HP:0200039)3.38767871
13Hematochezia (HP:0002573)3.32892791
14Recurrent fungal infections (HP:0002841)3.23574732
15Arterial tortuosity (HP:0005116)3.20924791
16Recurrent gram-negative bacterial infections (HP:0005420)3.19929439
17Right ventricular cardiomyopathy (HP:0011663)3.19340018
18Malnutrition (HP:0004395)3.12120301
19Aortic aneurysm (HP:0004942)3.08644243
20Encephalitis (HP:0002383)3.08426487
21Abnormality of T cells (HP:0002843)3.04392980
22Ileus (HP:0002595)2.92966383
23Gastrointestinal infarctions (HP:0005244)2.90829871
24Abnormality of macrophages (HP:0004311)2.90582750
25Prostate neoplasm (HP:0100787)2.89525334
26Spontaneous hematomas (HP:0007420)2.89166458
27Thyroiditis (HP:0100646)2.87142256
28Recurrent viral infections (HP:0004429)2.82412614
29Abnormal delayed hypersensitivity skin test (HP:0002963)2.76511941
30Vascular tortuosity (HP:0004948)2.74473681
31Abnormality of glutamine family amino acid metabolism (HP:0010902)2.73172980
32Autoimmune hemolytic anemia (HP:0001890)2.72100322
33Gingivitis (HP:0000230)2.69307498
34Systemic lupus erythematosus (HP:0002725)2.66573342
35Periodontitis (HP:0000704)2.64748707
36Increased IgE level (HP:0003212)2.63987954
37Pulmonary embolism (HP:0002204)2.60998628
38Recurrent cutaneous fungal infections (HP:0011370)2.57105675
39Chronic mucocutaneous candidiasis (HP:0002728)2.57105675
40Mediastinal lymphadenopathy (HP:0100721)2.54502129
41Vasculitis (HP:0002633)2.53116170
42Abnormal tarsal ossification (HP:0008369)2.51268297
43Cheilitis (HP:0100825)2.48421421
44Micronodular cirrhosis (HP:0001413)2.45867214
45Glomerulonephritis (HP:0000099)2.45707249
46Colitis (HP:0002583)2.45471298
47Disinhibition (HP:0000734)2.44166882
48Subacute progressive viral hepatitis (HP:0006572)2.44087101
49IgG deficiency (HP:0004315)2.43322630
50Vacuolated lymphocytes (HP:0001922)2.35990821
51Abnormal foot bone ossification (HP:0010675)2.35412912
52Inflammation of the large intestine (HP:0002037)2.35039375
53Osteomyelitis (HP:0002754)2.33318402
54Joint swelling (HP:0001386)2.31901441
55Combined immunodeficiency (HP:0005387)2.30678151
56Keratoconjunctivitis sicca (HP:0001097)2.30258497
57Recurrent bronchitis (HP:0002837)2.28927196
58Abnormality of the fingertips (HP:0001211)2.28708012
59Urinary glycosaminoglycan excretion (HP:0003541)2.27986899
60Mucopolysacchariduria (HP:0008155)2.27986899
61Cellulitis (HP:0100658)2.27767777
62Flat acetabular roof (HP:0003180)2.26474398
63Flattened epiphyses (HP:0003071)2.26143242
64Premature loss of primary teeth (HP:0006323)2.24287411
65Increased cerebral lipofuscin (HP:0011813)2.23977312
66Panhypogammaglobulinemia (HP:0003139)2.23262252
67Metabolic alkalosis (HP:0200114)2.22420448
68Epiphyseal dysplasia (HP:0002656)2.22219821
69Gastrointestinal inflammation (HP:0004386)2.20832452
70Complement deficiency (HP:0004431)2.20031001
71Milia (HP:0001056)2.19816842
72Papilledema (HP:0001085)2.19569053
73Xanthomatosis (HP:0000991)2.19424255
74Abnormality of mucopolysaccharide metabolism (HP:0011020)2.19267768
75Abnormality of polysaccharide metabolism (HP:0011012)2.19267768
76Abnormality of glycosaminoglycan metabolism (HP:0004371)2.19267768
77Arterial thrombosis (HP:0004420)2.16795407
78Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.16722622
79Keratoconjunctivitis (HP:0001096)2.15529739
80Gingival bleeding (HP:0000225)2.15512773
81Pulmonary infiltrates (HP:0002113)2.15438659
82Abnormality of proline metabolism (HP:0010907)2.15237354
83Hydroxyprolinuria (HP:0003080)2.15237354
84Granulocytopenia (HP:0001913)2.13310661
85IgM deficiency (HP:0002850)2.11299396
86Hypoplasia of the thymus (HP:0000778)2.10703873
87Recurrent skin infections (HP:0001581)2.09916313
88Abnormality of the gastric mucosa (HP:0004295)2.08829728
89B lymphocytopenia (HP:0010976)2.08540182
90Abnormality of B cell number (HP:0010975)2.08540182
91Fat malabsorption (HP:0002630)2.07958724
92Anorexia (HP:0002039)2.07753665
93Hypobetalipoproteinemia (HP:0003563)2.07657305
94Eosinophilia (HP:0001880)2.06977062
95Loss of speech (HP:0002371)2.06909320
96Increased CSF protein (HP:0002922)2.06641490
97Severe combined immunodeficiency (HP:0004430)2.06146161
98Stomach cancer (HP:0012126)2.05859918
99Nephritis (HP:0000123)2.04963394
100Abnormal albumin level (HP:0012116)2.04317396
101Hypoalbuminemia (HP:0003073)2.04317396
102Abnormality of the pleura (HP:0002103)2.03572655
103Hypoproteinemia (HP:0003075)2.03444993
104Interstitial pulmonary disease (HP:0006530)2.03335525
105Mesangial abnormality (HP:0001966)2.02013317
106Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01609027
107Abdominal distention (HP:0003270)2.01154801
108Cupped ribs (HP:0000887)1.99688460
109Hyperactive renin-angiotensin system (HP:0000841)1.99665747
110Abnormality of T cell physiology (HP:0011840)1.98780983
111Abnormality of liposaccharide metabolism (HP:0010968)1.97982990
112Abnormality of glycosphingolipid metabolism (HP:0004343)1.97982990
113Abnormality of glycolipid metabolism (HP:0010969)1.97982990
114Exotropia (HP:0000577)1.96913171
115Acanthocytosis (HP:0001927)1.96580484
116Cerebral aneurysm (HP:0004944)1.94840488
117Epistaxis (HP:0000421)1.94665444
118Gangrene (HP:0100758)1.94002476
119Meningitis (HP:0001287)1.92824547
120Abnormality of eosinophils (HP:0001879)1.92585034
121Sepsis (HP:0100806)1.91653816
122Decreased circulating renin level (HP:0003351)1.91648779
123Chest pain (HP:0100749)1.91542704
124Hemoptysis (HP:0002105)1.90190183
125Small epiphyses (HP:0010585)1.89196309
126Recurrent pneumonia (HP:0006532)1.87429005
127Neoplasm of the tracheobronchial system (HP:0100552)1.87246414
128Elevated erythrocyte sedimentation rate (HP:0003565)1.86838879
129Increased circulating renin level (HP:0000848)1.86364571
130Leukocytosis (HP:0001974)1.86288916
131Increased neuronal autofluorescent lipopigment (HP:0002074)1.85978305
132Woolly hair (HP:0002224)1.85957908
133Vertigo (HP:0002321)1.85589704
134Lymphopenia (HP:0001888)1.85375249
135Acute hepatic failure (HP:0006554)1.85295813
136Persistence of primary teeth (HP:0006335)1.85016815
137Acne (HP:0001061)1.84953006
138Focal segmental glomerulosclerosis (HP:0000097)1.84731468
139Aortic dissection (HP:0002647)1.83428733
140Urethral obstruction (HP:0000796)1.81985095
141Plantar hyperkeratosis (HP:0007556)1.81944359
142Chronic obstructive pulmonary disease (HP:0006510)1.81385848
143Obstructive lung disease (HP:0006536)1.81385848
144Dysostosis multiplex (HP:0000943)1.79850898
145Abnormality of chloride homeostasis (HP:0011422)1.78129071
146Agammaglobulinemia (HP:0004432)1.77910993
147Ureteral obstruction (HP:0006000)1.77186214
148Abnormality of cells of the lymphoid lineage (HP:0012140)1.77032677
149Bone pain (HP:0002653)1.73885589
150Petechiae (HP:0000967)1.73374538
151Mutism (HP:0002300)1.71771185
152Stomatitis (HP:0010280)1.71237090

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.42205560
2MST43.50612665
3RIPK43.35156993
4TGFBR23.21925386
5MST1R3.04431024
6LMTK23.00397056
7IRAK32.73113222
8MAP3K142.67073536
9TYK22.29948109
10ACVR1B2.25749810
11FGFR42.12111668
12AKT32.11512924
13SIK32.06681862
14CAMKK22.05551556
15TAOK32.04008571
16BLK1.96048056
17EPHB21.93766118
18MAP4K11.89280054
19JAK11.70148676
20EPHA31.61904003
21MAP3K21.61807959
22IRAK41.60826937
23MATK1.57795709
24TBK11.55504498
25MAP3K131.50490580
26MAP3K121.49693381
27MAP2K31.48584516
28PRKG21.44636657
29TXK1.43187047
30STK101.31946972
31RIPK11.31027394
32IKBKE1.30580622
33PRPF4B1.23334972
34CAMKK11.22942527
35GRK61.19932733
36PTK61.17207545
37MAP3K91.14157939
38MAP3K101.14048058
39GRK71.13301660
40ITK1.10489319
41IKBKB1.08573146
42FGFR31.08441156
43EPHA21.07155673
44NME11.03203775
45KSR11.02986634
46PAK41.02326824
47CSF1R1.01289623
48CHUK0.99837961
49ZAP700.99492341
50MYLK0.99412647
51MARK30.99134656
52NUAK10.98285363
53FGR0.97180286
54MAP2K20.97090776
55IRAK10.97083175
56CSK0.96864756
57EEF2K0.93978115
58EIF2AK30.92566441
59NEK60.92116761
60EIF2AK20.90530642
61MAP2K60.89519273
62JAK30.87496016
63PASK0.86713863
64EPHB10.84606064
65TEC0.84245702
66BMPR20.84024752
67RET0.82349848
68BMX0.79736296
69BTK0.79306477
70MAP3K30.78132349
71HCK0.77548174
72PDK20.75692118
73HIPK20.74640799
74SGK4940.74382844
75SGK2230.74382844
76DMPK0.74263959
77SYK0.71943507
78STK240.70645076
79SGK30.68443887
80STK30.68216455
81MAPK120.65757039
82KSR20.65264707
83FES0.65048277
84FGFR20.63612178
85PDK10.63087105
86MAPK110.62327853
87FYN0.61946065
88NLK0.61941923
89TESK20.61345926
90JAK20.60572667
91SGK20.60343602
92TNK20.59861551
93PIK3CG0.59132048
94PIM10.58779176
95LCK0.58759312
96LYN0.57775890
97MARK20.57517146
98STK380.56682714
99OXSR10.56629013
100SIK20.56050006
101MUSK0.55863958
102PIK3CA0.53671171
103MAPK70.53668840
104CDK60.53267089
105CDC42BPA0.52419610
106MAPK150.51891736
107ERN10.51845813
108PRKAA20.49597979
109TRPM70.49448466
110WNK10.49241264
111TYRO30.49007141
112FER0.46013534
113ADRBK20.45808313
114MAP3K110.45719675
115KIT0.45499369
116CAMK1G0.44992521
117YES10.44964256
118MAPKAPK20.44175021
119PDPK10.43938240
120ERBB20.42534456
121STK390.41527650
122SGK10.41488098
123STK110.40781161
124MAPKAPK30.40401659
125SCYL20.38873871
126MAP3K10.37035280
127PRKCQ0.35766146
128MAP3K70.35209242
129LRRK20.31957644
130TAOK10.31362724
131NTRK10.31055666
132ARAF0.30925534
133ABL10.30281323
134MELK0.29688459

Predicted pathways (KEGG)

RankGene SetZ-score
1Mineral absorption_Homo sapiens_hsa049782.20206207
2Leishmaniasis_Homo sapiens_hsa051402.11011020
3Osteoclast differentiation_Homo sapiens_hsa043802.00822408
4Autoimmune thyroid disease_Homo sapiens_hsa053201.90935421
5Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78850768
6Renin-angiotensin system_Homo sapiens_hsa046141.78105194
7Toll-like receptor signaling pathway_Homo sapiens_hsa046201.77354892
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.72751135
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.68885811
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.65452902
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63483757
12Toxoplasmosis_Homo sapiens_hsa051451.52545152
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.52035852
14B cell receptor signaling pathway_Homo sapiens_hsa046621.47918570
15Influenza A_Homo sapiens_hsa051641.46137647
16Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.46034067
17Fat digestion and absorption_Homo sapiens_hsa049751.46000684
18Carbohydrate digestion and absorption_Homo sapiens_hsa049731.45488048
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.43225132
20Pertussis_Homo sapiens_hsa051331.42930317
21TNF signaling pathway_Homo sapiens_hsa046681.40177645
22Salmonella infection_Homo sapiens_hsa051321.38166106
23Tuberculosis_Homo sapiens_hsa051521.34946416
24Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.34098992
25Hematopoietic cell lineage_Homo sapiens_hsa046401.33583518
26Legionellosis_Homo sapiens_hsa051341.26847988
27Intestinal immune network for IgA production_Homo sapiens_hsa046721.26761933
28Asthma_Homo sapiens_hsa053101.26759562
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24555198
30Measles_Homo sapiens_hsa051621.22809492
31Graft-versus-host disease_Homo sapiens_hsa053321.22617859
32Leukocyte transendothelial migration_Homo sapiens_hsa046701.17888875
33Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.15653117
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.15552628
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.15338919
36Protein digestion and absorption_Homo sapiens_hsa049741.12406779
37Chemokine signaling pathway_Homo sapiens_hsa040621.12326035
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12154940
39Cyanoamino acid metabolism_Homo sapiens_hsa004601.12153771
40Other glycan degradation_Homo sapiens_hsa005111.11583216
41AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10011308
42Pancreatic secretion_Homo sapiens_hsa049721.05025935
43Starch and sucrose metabolism_Homo sapiens_hsa005001.04172285
44African trypanosomiasis_Homo sapiens_hsa051431.03577560
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.02504530
46Apoptosis_Homo sapiens_hsa042100.98699093
47Chronic myeloid leukemia_Homo sapiens_hsa052200.97913819
48Pancreatic cancer_Homo sapiens_hsa052120.97263204
49Rheumatoid arthritis_Homo sapiens_hsa053230.96792164
50T cell receptor signaling pathway_Homo sapiens_hsa046600.96121110
51Adherens junction_Homo sapiens_hsa045200.95539754
52Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94532840
53Hepatitis C_Homo sapiens_hsa051600.92142717
54Primary immunodeficiency_Homo sapiens_hsa053400.92039679
55Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.90754065
56Shigellosis_Homo sapiens_hsa051310.90498679
57alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.90058298
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89600698
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88913906
60Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88161671
61Platelet activation_Homo sapiens_hsa046110.87525528
62Hepatitis B_Homo sapiens_hsa051610.86653228
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.86237128
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.86233517
65Salivary secretion_Homo sapiens_hsa049700.85492993
66Glycosaminoglycan degradation_Homo sapiens_hsa005310.85402265
67Prolactin signaling pathway_Homo sapiens_hsa049170.85171536
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84694174
69Gastric acid secretion_Homo sapiens_hsa049710.80863585
70VEGF signaling pathway_Homo sapiens_hsa043700.80381470
71PPAR signaling pathway_Homo sapiens_hsa033200.80204504
72Complement and coagulation cascades_Homo sapiens_hsa046100.80011651
73Non-small cell lung cancer_Homo sapiens_hsa052230.77633299
74Small cell lung cancer_Homo sapiens_hsa052220.75685987
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.75489947
76Allograft rejection_Homo sapiens_hsa053300.75288424
77Lysosome_Homo sapiens_hsa041420.74707950
78Linoleic acid metabolism_Homo sapiens_hsa005910.74336446
79Vitamin digestion and absorption_Homo sapiens_hsa049770.73323582
80Antigen processing and presentation_Homo sapiens_hsa046120.72926028
81Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72758074
82Herpes simplex infection_Homo sapiens_hsa051680.72732471
83Galactose metabolism_Homo sapiens_hsa000520.72718706
84Insulin resistance_Homo sapiens_hsa049310.71299131
85Acute myeloid leukemia_Homo sapiens_hsa052210.69748794
86Endometrial cancer_Homo sapiens_hsa052130.69579157
87Malaria_Homo sapiens_hsa051440.67767462
88Histidine metabolism_Homo sapiens_hsa003400.67355916
89ABC transporters_Homo sapiens_hsa020100.65897896
90Sphingolipid metabolism_Homo sapiens_hsa006000.65263860
91Amoebiasis_Homo sapiens_hsa051460.65255945
92Bile secretion_Homo sapiens_hsa049760.64242699
93Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63778342
94Renin secretion_Homo sapiens_hsa049240.63031873
95Sphingolipid signaling pathway_Homo sapiens_hsa040710.62715764
96Ether lipid metabolism_Homo sapiens_hsa005650.62498871
97Inositol phosphate metabolism_Homo sapiens_hsa005620.62004528
98Colorectal cancer_Homo sapiens_hsa052100.61700666
99Type II diabetes mellitus_Homo sapiens_hsa049300.61550383
100GnRH signaling pathway_Homo sapiens_hsa049120.61530681
101FoxO signaling pathway_Homo sapiens_hsa040680.60664616
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59698133
103Viral myocarditis_Homo sapiens_hsa054160.59600991
104Long-term potentiation_Homo sapiens_hsa047200.59591723
105Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.59569130
106Glycerolipid metabolism_Homo sapiens_hsa005610.58819386
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.58169932
108Thyroid hormone synthesis_Homo sapiens_hsa049180.56389271
109Dorso-ventral axis formation_Homo sapiens_hsa043200.56149478
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.55860871
111Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55739421
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54982573
113Caffeine metabolism_Homo sapiens_hsa002320.54801280
114Staphylococcus aureus infection_Homo sapiens_hsa051500.54423184
115mTOR signaling pathway_Homo sapiens_hsa041500.54383397
116Type I diabetes mellitus_Homo sapiens_hsa049400.53333910
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51734249
118ErbB signaling pathway_Homo sapiens_hsa040120.51077786
119Rap1 signaling pathway_Homo sapiens_hsa040150.49764431
120Focal adhesion_Homo sapiens_hsa045100.49739642
121Estrogen signaling pathway_Homo sapiens_hsa049150.49282318
122Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49020566
123Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47456107
124Thyroid cancer_Homo sapiens_hsa052160.47334779
125Phagosome_Homo sapiens_hsa041450.47285738
126Arachidonic acid metabolism_Homo sapiens_hsa005900.46939580
127Choline metabolism in cancer_Homo sapiens_hsa052310.46437736

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